                         SEQUENCE LISTING

<110>  Ashmaig, Mohmed  E.
       Krauss, Ronald  M.
 
<120>  Ultra-Small ApoB-Containing Particles and Methods of Use Thereof

<130>  CHOR-059WO

<150>  61/497,847
<151>  2011-06-16

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  2
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 
1               5                   10                  15      


Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 
            20                  25                  30          


Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 
        35                  40                  45              


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 
    50                  55                  60                  


Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 
65                  70                  75                  80  


Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
        115                 120                 125             


Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 
    130                 135                 140                 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 
                165                 170                 175     


Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 
            180                 185                 190         


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 
        195                 200                 205             


Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
    210                 215                 220                 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
225                 230                 235                 240 


Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 
                245                 250                 255     


Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 
            260                 265                 270         


Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 
    290                 295                 300                 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 
305                 310                 315                 320 


Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 
                325                 330                 335     


Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 
            340                 345                 350         


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 
        355                 360                 365             


Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
385                 390                 395                 400 


Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 
                405                 410                 415     


Gly Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Ser Gln Ala 
            420                 425                 430         


Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly Ser 
        435                 440                 445             


Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys Lys 
    450                 455                 460                 


Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val Leu 
465                 470                 475                 480 


Pro Lys 
        


