                         SEQUENCE LISTING

<110>  Deato, Maria
       Yang, Hong
       Kaplan, Daniel David
 
<120>  Methods of Treating Glucose Metabolism Disorders

<130>  NGMB-0119WO

<150>  61/496,407
<151>  2011-06-13

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Leu Arg Arg Ala His Glu Val Ala Leu Arg Leu Leu Leu 
1               5                   10                  15      


Cys Arg Pro Trp Ala Ser Arg Ala Ala Ala Arg Pro Lys Pro Ser Ala 
            20                  25                  30          


Ser Glu Val Leu Thr Arg His Leu Leu Gln Arg Arg Leu Pro His Trp 
        35                  40                  45              


Thr Ser Phe Cys Val Pro Tyr Ser Ala Val Arg Asn Asp Gln Phe Gly 
    50                  55                  60                  


Leu Ser His Phe Asn Trp Pro Val Gln Gly Ala Asn Tyr His Val Leu 
65                  70                  75                  80  


Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro 
                85                  90                  95      


Trp Gln Asp Leu Ala Arg Gln Asn Arg Phe Phe Thr Ala Leu Lys Val 
            100                 105                 110         


Val Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu 
        115                 120                 125             


Phe Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr 
    130                 135                 140                 


Val Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met Tyr 
145                 150                 155         


<210>  2
<211>  157
<212>  PRT
<213>  Canis familiaris

<400>  2

Met Glu Pro Leu Arg Arg Ala His Glu Ala Ala Val Arg Leu Leu Leu 
1               5                   10                  15      


Cys Gly Pro Trp Ala Ser Gly Ala Ala Ser Arg Pro Lys Pro Arg Ala 
            20                  25                  30          


Ser Glu Val Leu Thr Arg His Leu Leu Gln Arg Arg Leu Pro His Trp 
        35                  40                  45              


Thr Ser Phe Cys Val Pro Tyr Ser Ala Val Arg Asn Asp Gln Phe Gly 
    50                  55                  60                  


Leu Ser His Phe Asn Trp Pro Val Gln Gly Ala Asn Tyr His Val Leu 
65                  70                  75                  80  


Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro 
                85                  90                  95      


Trp Gln Asp Leu Ala Ala Gln Asp Arg Phe Phe Thr Ala Leu Lys Val 
            100                 105                 110         


Val Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu 
        115                 120                 125             


Phe Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr 
    130                 135                 140                 


Val Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met Tyr 
145                 150                 155         


<210>  3
<211>  157
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Glu Pro Leu Arg Arg Ala His Glu Ala Met Leu Arg Leu Leu Leu 
1               5                   10                  15      


Trp Gly Pro Trp Ala Ser Gly Ala Ala Ser Arg Pro Lys Pro Arg Ala 
            20                  25                  30          


Ser Glu Val Leu Thr Arg His Leu Leu Gln Arg Arg Leu Pro His Trp 
        35                  40                  45              


Thr Ser Phe Cys Val Pro Tyr Ser Ala Val His Asn Asp Gln Phe Gly 
    50                  55                  60                  


Leu Ser His Phe Asn Trp Pro Val Pro Gly Ala Asn Tyr His Val Leu 
65                  70                  75                  80  


Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro 
                85                  90                  95      


Trp Gln Asp Leu Ala Ala Gln Asn Arg Phe Phe Thr Ala Leu Lys Val 
            100                 105                 110         


Ile Asn Met Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu 
        115                 120                 125             


Phe Ala Lys Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr 
    130                 135                 140                 


Ile Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met Tyr 
145                 150                 155         


<210>  4
<211>  157
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Ala Leu Arg Arg Ala His Glu Ala Thr Leu Arg Leu Leu Leu 
1               5                   10                  15      


Cys Arg Pro Trp Ala Ser Gly Ala Ala Ser Arg Pro Lys Pro Arg Ala 
            20                  25                  30          


Ser Glu Val Leu Thr Gln His Leu Leu Gln Arg Arg Leu Pro His Trp 
        35                  40                  45              


Thr Ser Phe Cys Val Pro Tyr Ser Ala Val His Asn Asp Gln Phe Gly 
    50                  55                  60                  


Leu Ser His Phe Asn Trp Pro Val Leu Gly Ala Asn Tyr His Val Leu 
65                  70                  75                  80  


Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro 
                85                  90                  95      


Trp Gln Asp Leu Ala Pro Gln Asp Arg Phe Phe Thr Ala Leu Lys Val 
            100                 105                 110         


Ile Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu 
        115                 120                 125             


Phe Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr 
    130                 135                 140                 


Ile Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met Tyr 
145                 150                 155         


<210>  5
<211>  312
<212>  PRT
<213>  Monodelphis domestica

<400>  5

Met Glu Leu Leu Arg Arg Ala His Glu Ala Ala Leu Arg Leu Val Leu 
1               5                   10                  15      


Trp Leu Asn Pro Gln Thr Thr Ala Arg Gly Pro Lys Pro Arg Ala Ser 
            20                  25                  30          


Glu Val Leu Thr Gln His Leu Leu Gln Arg Arg Leu Pro His Trp Thr 
        35                  40                  45              


Ser Phe Cys Val Pro Tyr Ser Ala Val His Asn Asp Gln Phe Gly Leu 
    50                  55                  60                  


Ser His Phe Asn Trp Val Val Gln Gly Ala Asn Tyr His Ile Leu Arg 
65                  70                  75                  80  


Thr Gly Cys Phe Ser Phe Phe Lys Tyr His Cys Ser Asn Val Pro Trp 
                85                  90                  95      


Gln Asp Leu Gly Gln Gln Asp Gln Phe Phe Thr Ala Leu Lys Val Ile 
            100                 105                 110         


Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu Phe 
        115                 120                 125             


Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr Ile 
    130                 135                 140                 


Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met Tyr Met Glu Leu Leu 
145                 150                 155                 160 


Arg Arg Ala His Glu Ala Ala Leu Arg Leu Val Leu Trp Leu Asn Pro 
                165                 170                 175     


Gln Thr Thr Ala Arg Gly Pro Lys Pro Arg Ala Ser Glu Val Leu Thr 
            180                 185                 190         


Gln His Leu Leu Gln Arg Arg Leu Pro His Trp Thr Ser Phe Cys Val 
        195                 200                 205             


Pro Tyr Ser Ala Val His Asn Asp Gln Phe Gly Leu Ser His Phe Asn 
    210                 215                 220                 


Trp Val Val Gln Gly Ala Asn Tyr His Ile Leu Arg Thr Gly Cys Phe 
225                 230                 235                 240 


Ser Phe Phe Lys Tyr His Cys Ser Asn Val Pro Trp Gln Asp Leu Gly 
                245                 250                 255     


Gln Gln Asp Gln Phe Phe Thr Ala Leu Lys Val Ile Asn Leu Gly Ile 
            260                 265                 270         


Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu Phe Ala Arg Val Thr 
        275                 280                 285             


Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr Ile Tyr Phe Leu Asn 
    290                 295                 300                 


Lys Glu Asp Glu Gly Ala Met Tyr 
305                 310         


<210>  6
<211>  156
<212>  PRT
<213>  Danio rerio

<400>  6

Met Thr Asp Ile Leu Arg Arg Val His Gly Cys Phe Leu Lys Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Thr Phe Arg Asn Lys Ala Val Arg Pro Ser Ala Ser 
            20                  25                  30          


Glu Val Leu Thr Cys His Leu Thr Gln Arg Ala Leu Pro Pro Trp Thr 
        35                  40                  45              


Ser Phe Cys Val Arg Tyr Arg Asp Val Ile Asn Asp Gln Phe Gly Leu 
    50                  55                  60                  


Ser Asn Phe Asn Trp Gln Val Gln Gly Thr Asn Tyr His Ile Leu Arg 
65                  70                  75                  80  


Thr Gly Ala Phe Pro Phe Ile Lys Tyr His Cys Thr Lys Ala Pro Pro 
                85                  90                  95      


Gln Asn Leu Gln Phe Glu Asn Thr Phe Phe Gly Ala Leu Lys Val Ile 
            100                 105                 110         


Asn Leu Gly Ile Pro Cys Leu Ala Tyr Gly Leu Gly Ser Trp Met Val 
        115                 120                 125             


Val Gly Val Thr Glu Thr Val Gln Thr Ser Ala Gly Pro Val Thr Val 
    130                 135                 140                 


Tyr Phe Ala Tyr Lys Glu Ala Glu Gly Ala Gln Phe 
145                 150                 155     


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Gly Ser Gly Gly Ser 
1               5   


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Gly Gly Gly Ser 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Gly Gly Ser Gly 
1               


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Gly Gly Ser Gly Gly 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Gly Ser Gly Ser Gly 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Gly Ser Gly Gly Gly 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Gly Gly Gly Ser Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Gly Ser Ser Ser Gly 
1               5   


<210>  15
<211>  474
<212>  DNA
<213>  Mus musculus

<400>  15
atggaggccc tgcggagggc ccacgaggct acgctgcggc tgctgctgtg ccggccctgg       60

gcctcgggcg ccgcctcccg cccgaagccc cgcgcctcgg aggtgctgac gcagcacctg      120

ctgcagcggc ggctgccgca ctggacttcc ttctgcgtgc cctacagtgc ggtccacaac      180

gaccagttcg gcctgtcgca cttcaattgg ccggtgctgg gcgccaacta ccacgtcctg      240

cgcaccggct gcttcccctt catcaagtac cactgctcca aggcgccctg gcaggacctg      300

gccccgcagg accgcttctt caccgcgctc aaggtcatca acctgggtat tccaacttta      360

ttatatggac ttggctcctg gttatttgcc agagtcacag agactgttca taccagttac      420

ggaccaataa caatctattt tctaaataaa gaagatgaag gtgccatgta ttga            474


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  16
atggaggccc tgcggagggc cca                                               23


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  17
tcaatacatg gcaccttcat ct                                                22


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  18
atggaggccc tgaggagggc cca                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  19
tcaatacatg gcaccttcat ctt                                               23


<210>  20
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  20
atggaggccc tgaggagggc ccacgaggtc gcgctccgcc tgctgctgtg taggccgtgg       60

gcctcgcgcg ccgccgcccg ccccaagccc agcgcctcgg aggtgctgac gcggcatctg      120

ctgcagcggc gcctgccgca ctggacctcc ttctgcgtgc cctacagcgc cgtccgcaac      180

gaccagttcg gcctctcgca cttcaactgg ccggtgcagg gcgccaacta ccacgtcctg      240

cgcaccggct gcttcccctt catcaagtac cactgctcca aggctccctg gcaggacctg      300

gcccggcaga accgcttctt cacggcgctc aaggtcgtca acctcggtat tccaacttta      360

ttatatggac ttggctcctg gttatttgcc agagtcacag agactgtgca taccagttat      420

ggacccataa cagtttattt tctcaataaa gaagatgaag gtgccatgta ttga            474


