
                                SEQUENCE LISTING

<110> CHRONTECH PHARMA AB
      Sallberg, Matti
      Frelin, Lars
      

<120> INJECTION NEEDLE AND DEVICE

<130> TRIPEP.125WO

<150> 61/497442             
<151> 2011-06-15

<150> 61/500066
<151> 2011-06-22

<150> 61/587066
<151> 2012-01-16

<150> 61/597112
<151> 2012-02-09

<150> 61/642356
<151> 2012-05-03

<160> 33

<210> 1
<211> 183
<212> PRT
<213> Artificial Sequence

<220> 
<223> HBCAg (amino acid seq)

<400> 1
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu
 1               5                  10                  15      
Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp
            20                  25                  30          
Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu
    50                  55                  60                  
Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala
65                  70                  75                  80  
Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys
                85                  90                  95      
Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg
            100                 105                 110         
Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr
145                 150                 155                 160 
Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser
                165                 170                 175     
Gln Ser Arg Glu Ser Gln Cys
            180             


<210> 2
<211> 552
<212> DNA
<213> wild-type HBcAg

<400> 2
atggacatcg acccttataa agaatttgga gctactgtgg agttactctc gtttttgccc 60
tccgacttct ttccttcagt acgagatctt ctagataccg cctcagctct gtatcgggaa 120
gccttagagt ctcctgagca ttgttcacct caccatactg cactcaggca agcaattctt 180
tgctgggggg aactaatgac tctagctacc tgggtgggtg ttaatttgga agatccagcg 240
tctagagacc tagtagtcag ttatgtcaac actaatatgg gcctaaagtt caggcaactc 300
ttgtggtttc acatttcttg tctcactttt ggaagagaaa cagttataga gtatttggtg 360
tctttcggag tgtggattcg cactcctcca gcttatagac caccaaatgc ccctatccta 420
tcaacacttc cggagactac tgttgttaga cgacgaggca ggtcccctag aagaagaact 480
ccctcgcctc gcagacgaag gtctcaatcg ccgcgtcgca gaagatctca atctcgggaa 540
tctcaatgtt ag                                                     552

<210> 3
<211> 552
<212> DNA
<213> Artificial Sequence

<220> 
<223> HBCAg (codon optimized nt seq)

<400> 3
atggacatcg acccctacaa ggagttcggc gccaccgtgg agctgctgag cttcctgccc 60
agcgacttct tccccagcgt gcgcgacctg ctggacaccg ccagcgccct gtaccgcgag 120
gccctggaga gccccgagca ctgcagcccc caccacaccg ccctgcgcca ggccatcctg 180
tgctggggcg agctgatgac cctggccacc tgggtgggcg tgaacctgga ggaccccgcc 240
agccgcgacc tggtggtgag ctacgtgaac accaacatgg gcctgaagtt ccgccagctg 300
ctgtggttcc acatcagctg cctgaccttc ggccgcgaga ccgtgatcga gtacctggtg 360
agcttcggcg tgtggatccg cacccccccc gcctaccgcc cccccaacgc ccccatcctg 420
agcaccctgc ccgagaccac cgtggtgcgc cgccgcggcc gcagcccccg ccgccgcacc 480
cccagccccc gccgccgccg cagccagagc ccccgccgcc gccgcagcca gagccgcgag 540
agccagtgct ag                                                     552

<210> 4
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A junction (amino acid sequence)

<400> 4
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
 1               5                  10                  15      
Val Leu
        


<210> 5
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A junction (codon optimized nt seq)

<400> 5
agcgccgacc tggaggtggt gaccagcacc tgggtgctgg tgggcggcgt gctg       54

<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS4A/B junction (amino acid sequence)

<400> 6
Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Tyr Ile Glu Gln Gly
 1               5                  10                  15      


<210> 7
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS4A/B junction (nucleotide sequence)

<400> 7
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggc              48

<210> 8
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-1 NS3/4A-HBcAg (NS3-NS4A-HBcAg fusion with
      active protease) (amino acid sequence)

<400> 8
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Pro Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 9
<211> 2610
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg (NS3-NS4A-HBcAg fusion with active
      protease) (nucleotide sequence sequence)

<400> 9
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccccca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcat ggacatcgac ccctacaagg agttcggcgc caccgtggag 2100
ctgctgagct tcctgcccag cgacttcttc cccagcgtgc gcgacctgct ggacaccgcc 2160
agcgccctgt accgcgaggc cctggagagc cccgagcact gcagccccca ccacaccgcc 2220
ctgcgccagg ccatcctgtg ctggggcgag ctgatgaccc tggccacctg ggtgggcgtg 2280
aacctggagg accccgccag ccgcgacctg gtggtgagct acgtgaacac caacatgggc 2340
ctgaagttcc gccagctgct gtggttccac atcagctgcc tgaccttcgg ccgcgagacc 2400
gtgatcgagt acctggtgag cttcggcgtg tggatccgca ccccccccgc ctaccgcccc 2460
cccaacgccc ccatcctgag caccctgccc gagaccaccg tggtgcgccg ccgcggccgc 2520
agcccccgcc gccgcacccc cagcccccgc cgccgccgca gccagagccc ccgccgccgc 2580
cgcagccaga gccgcgagag ccagtgctag                                  2610

<210> 10
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-2 Mutant(catalytic triade)NS3/4A-HBcAg
      (NS3-NS4A-HBcAg fusion with inactive protease)
      (amino acid sequence)

<400> 10
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr Ala Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Ala Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 11
<211> 2610
<212> DNA
<213> Artificial Sequence

<220> 
<223> Mutant(catalytic triade)NS3/4A-HBcAg
      (NS3-NS4A-HBcAg fusion with inactive protease)
      (nucleotide sequence)

<400> 11
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta cgccggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggccctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcat ggacatcgac ccctacaagg agttcggcgc caccgtggag 2100
ctgctgagct tcctgcccag cgacttcttc cccagcgtgc gcgacctgct ggacaccgcc 2160
agcgccctgt accgcgaggc cctggagagc cccgagcact gcagccccca ccacaccgcc 2220
ctgcgccagg ccatcctgtg ctggggcgag ctgatgaccc tggccacctg ggtgggcgtg 2280
aacctggagg accccgccag ccgcgacctg gtggtgagct acgtgaacac caacatgggc 2340
ctgaagttcc gccagctgct gtggttccac atcagctgcc tgaccttcgg ccgcgagacc 2400
gtgatcgagt acctggtgag cttcggcgtg tggatccgca ccccccccgc ctaccgcccc 2460
cccaacgccc ccatcctgag caccctgccc gagaccaccg tggtgcgccg ccgcggccgc 2520
agcccccgcc gccgcacccc cagcccccgc cgccgccgca gccagagccc ccgccgccgc 2580
cgcagccaga gccgcgagag ccagtgctag                                  2610

<210> 12
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-3 NS3/4A-HBcAg (NS3 and NS4A-HBcAg fusion)
      (amino acid sequence)

<400> 12
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 13
<211> 2610
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg (NS3 and NS4A-HBcAg fusion)
      (nucleotide sequence)

<400> 13
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcat ggacatcgac ccctacaagg agttcggcgc caccgtggag 2100
ctgctgagct tcctgcccag cgacttcttc cccagcgtgc gcgacctgct ggacaccgcc 2160
agcgccctgt accgcgaggc cctggagagc cccgagcact gcagccccca ccacaccgcc 2220
ctgcgccagg ccatcctgtg ctggggcgag ctgatgaccc tggccacctg ggtgggcgtg 2280
aacctggagg accccgccag ccgcgacctg gtggtgagct acgtgaacac caacatgggc 2340
ctgaagttcc gccagctgct gtggttccac atcagctgcc tgaccttcgg ccgcgagacc 2400
gtgatcgagt acctggtgag cttcggcgtg tggatccgca ccccccccgc ctaccgcccc 2460
cccaacgccc ccatcctgag caccctgccc gagaccaccg tggtgcgccg ccgcggccgc 2520
agcccccgcc gccgcacccc cagcccccgc cgccgccgca gccagagccc ccgccgccgc 2580
cgcagccaga gccgcgagag ccagtgctag                                  2610

<210> 14
<211> 879
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-4 NS3/4A-4Bjunct-HBcAg (NS3 AND NS4A AND
      HBcAg) (amino acid sequence)

<400> 14
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Met Asp Ile Asp Pro Tyr Lys Glu
    690                 695                 700                 
Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe
705                 710                 715                 720 
Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu
                725                 730                 735     
Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg
            740                 745                 750         
Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val
        755                 760                 765             
Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Tyr
    770                 775                 780                 
Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp Phe His
785                 790                 795                 800 
Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr Leu Val
                805                 810                 815     
Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn
            820                 825                 830         
Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg
        835                 840                 845             
Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser
    850                 855                 860                 
Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser Gln Cys
865                 870                 875                 


<210> 15
<211> 2640
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg (NS3 AND NS4A AND HBcAg)
      (nucleotide sequence)

<400> 15
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcat ggacatcgac 2100
ccctacaagg agttcggcgc caccgtggag ctgctgagct tcctgcccag cgacttcttc 2160
cccagcgtgc gcgacctgct ggacaccgcc agcgccctgt accgcgaggc cctggagagc 2220
cccgagcact gcagccccca ccacaccgcc ctgcgccagg ccatcctgtg ctggggcgag 2280
ctgatgaccc tggccacctg ggtgggcgtg aacctggagg accccgccag ccgcgacctg 2340
gtggtgagct acgtgaacac caacatgggc ctgaagttcc gccagctgct gtggttccac 2400
atcagctgcc tgaccttcgg ccgcgagacc gtgatcgagt acctggtgag cttcggcgtg 2460
tggatccgca ccccccccgc ctaccgcccc cccaacgccc ccatcctgag caccctgccc 2520
gagaccaccg tggtgcgccg ccgcggccgc agcccccgcc gccgcacccc cagcccccgc 2580
cgccgccgca gccagagccc ccgccgccgc cgcagccaga gccgcgagag ccagtgctag 2640


<210> 16
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-5
      NS3/4A-4Bjunct-HBcAg1-44-NS3/4Ajunct-HBc45-87-NS3/
      4Ajunct-HBc88-141-NS3/4Ajunct-HBc142-183 (amino
      acid sequence)

<400> 16
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Met Asp Ile Asp Pro Tyr Lys Glu
    690                 695                 700                 
Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe
705                 710                 715                 720 
Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu
                725                 730                 735     
Ala Leu Glu Ser Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val
            740                 745                 750         
Leu Val Gly Gly Val Leu Pro Glu His Cys Ser Pro His His Thr Ala
        755                 760                 765             
Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr
    770                 775                 780                 
Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val
785                 790                 795                 800 
Ser Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly
                805                 810                 815     
Gly Val Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu
            820                 825                 830         
Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile
        835                 840                 845             
Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr
    850                 855                 860                 
Arg Pro Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val Val
865                 870                 875                 880 
Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Thr Leu Pro Glu Thr
                885                 890                 895     
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
            900                 905                 910         
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
        915                 920                 925             
Arg Glu Ser Gln Cys
    930             


<210> 17
<211> 2802
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg1-44-NS3/4Ajunct-HBc45-87-NS3/
      4Ajunct-HBc88-141-NS3/4Ajunct-HBc142-183
      (nucleotide sequence)

<400> 17
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcat ggacatcgac 2100
ccctacaagg agttcggcgc caccgtggag ctgctgagct tcctgcccag cgacttcttc 2160
cccagcgtgc gcgacctgct ggacaccgcc agcgccctgt accgcgaggc cctggagagc 2220
agcgccgacc tggaggtggt gaccagcacc tgggtgctgg tgggcggcgt gctgcccgag 2280
cactgcagcc cccaccacac cgccctgcgc caggccatcc tgtgctgggg cgagctgatg 2340
accctggcca cctgggtggg cgtgaacctg gaggaccccg ccagccgcga cctggtggtg 2400
agcagcgccg acctggaggt ggtgaccagc acctgggtgc tggtgggcgg cgtgctgtac 2460
gtgaacacca acatgggcct gaagttccgc cagctgctgt ggttccacat cagctgcctg 2520
accttcggcc gcgagaccgt gatcgagtac ctggtgagct tcggcgtgtg gatccgcacc 2580
ccccccgcct accgcccccc caacgccccc atcctgagca gcgccgacct ggaggtggtg 2640
accagcacct gggtgctggt gggcggcgtg ctgaccctgc ccgagaccac cgtggtgcgc 2700
cgccgcggcc gcagcccccg ccgccgcacc cccagccccc gccgccgccg cagccagagc 2760
ccccgccgcc gccgcagcca gagccgcgag agccagtgct ag                    2802

<210> 18
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-6
      NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc45-87-N
      S3/4Ajunct-HBc88-141-NS3/4Ajunct-HBc1-44 (amino
      acid sequence)

<400> 18
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Thr Leu Pro Glu Thr Thr Val Val
    690                 695                 700                 
Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg
705                 710                 715                 720 
Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser
                725                 730                 735     
Gln Cys Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val
            740                 745                 750         
Gly Gly Val Leu Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg
        755                 760                 765             
Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val
    770                 775                 780                 
Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Ser
785                 790                 795                 800 
Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val
                805                 810                 815     
Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp
            820                 825                 830         
Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr
        835                 840                 845             
Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro
    850                 855                 860                 
Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val Val Thr Ser
865                 870                 875                 880 
Thr Trp Val Leu Val Gly Gly Val Leu Met Asp Ile Asp Pro Tyr Lys
                885                 890                 895     
Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe
            900                 905                 910         
Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg
        915                 920                 925             
Glu Ala Leu Glu Ser
    930             


<210> 19
<211> 2802
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc45-87-N
      S3/4Ajunct-HBc88-141-NS3/4Ajunct-HBc1-44
      (nucleotide sequence)

<400> 19
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcac cctgcccgag 2100
accaccgtgg tgcgccgccg cggccgcagc ccccgccgcc gcacccccag cccccgccgc 2160
cgccgcagcc agagcccccg ccgccgccgc agccagagcc gcgagagcca gtgcagcgcc 2220
gacctggagg tggtgaccag cacctgggtg ctggtgggcg gcgtgctgcc cgagcactgc 2280
agcccccacc acaccgccct gcgccaggcc atcctgtgct ggggcgagct gatgaccctg 2340
gccacctggg tgggcgtgaa cctggaggac cccgccagcc gcgacctggt ggtgagcagc 2400
gccgacctgg aggtggtgac cagcacctgg gtgctggtgg gcggcgtgct gtacgtgaac 2460
accaacatgg gcctgaagtt ccgccagctg ctgtggttcc acatcagctg cctgaccttc 2520
ggccgcgaga ccgtgatcga gtacctggtg agcttcggcg tgtggatccg cacccccccc 2580
gcctaccgcc cccccaacgc ccccatcctg agcagcgccg acctggaggt ggtgaccagc 2640
acctgggtgc tggtgggcgg cgtgctgatg gacatcgacc cctacaagga gttcggcgcc 2700
accgtggagc tgctgagctt cctgcccagc gacttcttcc ccagcgtgcg cgacctgctg 2760
gacaccgcca gcgccctgta ccgcgaggcc ctggagagct ag                    2802

<210> 20
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-7
      NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc88-141-
      NS3/4Ajunct-HBc45-87-NS3/4Ajunct-HBc1-44 (amino
      acid sequence)

<400> 20
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Thr Leu Pro Glu Thr Thr Val Val
    690                 695                 700                 
Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg
705                 710                 715                 720 
Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser
                725                 730                 735     
Gln Cys Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val
            740                 745                 750         
Gly Gly Val Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln
        755                 760                 765             
Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val
    770                 775                 780                 
Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala
785                 790                 795                 800 
Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val
                805                 810                 815     
Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Pro Glu His Cys
            820                 825                 830         
Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu
        835                 840                 845             
Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala
    850                 855                 860                 
Ser Arg Asp Leu Val Val Ser Ser Ala Asp Leu Glu Val Val Thr Ser
865                 870                 875                 880 
Thr Trp Val Leu Val Gly Gly Val Leu Met Asp Ile Asp Pro Tyr Lys
                885                 890                 895     
Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe
            900                 905                 910         
Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg
        915                 920                 925             
Glu Ala Leu Glu Ser
    930             


<210> 21
<211> 2802
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc88-141-
      NS3/4Ajunct-HBc45-87-NS3/4Ajunct-HBc1-44
      (nucleotide sequence)

<400> 21
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcac cctgcccgag 2100
accaccgtgg tgcgccgccg cggccgcagc ccccgccgcc gcacccccag cccccgccgc 2160
cgccgcagcc agagcccccg ccgccgccgc agccagagcc gcgagagcca gtgcagcgcc 2220
gacctggagg tggtgaccag cacctgggtg ctggtgggcg gcgtgctgta cgtgaacacc 2280
aacatgggcc tgaagttccg ccagctgctg tggttccaca tcagctgcct gaccttcggc 2340
cgcgagaccg tgatcgagta cctggtgagc ttcggcgtgt ggatccgcac cccccccgcc 2400
taccgccccc ccaacgcccc catcctgagc agcgccgacc tggaggtggt gaccagcacc 2460
tgggtgctgg tgggcggcgt gctgcccgag cactgcagcc cccaccacac cgccctgcgc 2520
caggccatcc tgtgctgggg cgagctgatg accctggcca cctgggtggg cgtgaacctg 2580
gaggaccccg ccagccgcga cctggtggtg agcagcgccg acctggaggt ggtgaccagc 2640
acctgggtgc tggtgggcgg cgtgctgatg gacatcgacc cctacaagga gttcggcgcc 2700
accgtggagc tgctgagctt cctgcccagc gacttcttcc ccagcgtgcg cgacctgctg 2760
gacaccgcca gcgccctgta ccgcgaggcc ctggagagct ag                    2802

<210> 22
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONSTR-8
      NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc88-141-
      NS3/4Ajunct-HBc1-44-NS3/4Ajunct-HBc45-87 (amino
      acid sequence)

<400> 22
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Thr Leu Pro Glu Thr Thr Val Val
    690                 695                 700                 
Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg
705                 710                 715                 720 
Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser
                725                 730                 735     
Gln Cys Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val
            740                 745                 750         
Gly Gly Val Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln
        755                 760                 765             
Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val
    770                 775                 780                 
Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala
785                 790                 795                 800 
Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val
                805                 810                 815     
Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Met Asp Ile Asp
            820                 825                 830         
Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro
        835                 840                 845             
Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala
    850                 855                 860                 
Leu Tyr Arg Glu Ala Leu Glu Ser Ser Ala Asp Leu Glu Val Val Thr
865                 870                 875                 880 
Ser Thr Trp Val Leu Val Gly Gly Val Leu Pro Glu His Cys Ser Pro
                885                 890                 895     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            900                 905                 910         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        915                 920                 925             
Asp Leu Val Val Ser
    930             


<210> 23
<211> 2802
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc88-141-
      NS3/4Ajunct-HBc1-44-NS3/4Ajunct-HBc45-87
      (nucleotide sequence)

<400> 23
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcac cctgcccgag 2100
accaccgtgg tgcgccgccg cggccgcagc ccccgccgcc gcacccccag cccccgccgc 2160
cgccgcagcc agagcccccg ccgccgccgc agccagagcc gcgagagcca gtgcagcgcc 2220
gacctggagg tggtgaccag cacctgggtg ctggtgggcg gcgtgctgta cgtgaacacc 2280
aacatgggcc tgaagttccg ccagctgctg tggttccaca tcagctgcct gaccttcggc 2340
cgcgagaccg tgatcgagta cctggtgagc ttcggcgtgt ggatccgcac cccccccgcc 2400
taccgccccc ccaacgcccc catcctgagc agcgccgacc tggaggtggt gaccagcacc 2460
tgggtgctgg tgggcggcgt gctgatggac atcgacccct acaaggagtt cggcgccacc 2520
gtggagctgc tgagcttcct gcccagcgac ttcttcccca gcgtgcgcga cctgctggac 2580
accgccagcg ccctgtaccg cgaggccctg gagagcagcg ccgacctgga ggtggtgacc 2640
agcacctggg tgctggtggg cggcgtgctg cccgagcact gcagccccca ccacaccgcc 2700
ctgcgccagg ccatcctgtg ctggggcgag ctgatgaccc tggccacctg ggtgggcgtg 2760
aacctggagg accccgccag ccgcgacctg gtggtgagct ag                    2802

<210> 24
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg142-183-NS3/4Ajunct-HBc88-141-
      NS3/4Ajunct-HBc1-44-NS3/4Ajunct-HBc45-87
      (nucleotide sequence)

<400> 24
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Tyr Val Asn Thr Asn Met Gly Leu
    690                 695                 700                 
Lys Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly
705                 710                 715                 720 
Arg Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg
                725                 730                 735     
Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Ser Ala
            740                 745                 750         
Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu
        755                 760                 765             
Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg
    770                 775                 780                 
Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg
785                 790                 795                 800 
Arg Arg Ser Gln Ser Arg Glu Ser Gln Cys Ser Ala Asp Leu Glu Val
                805                 810                 815     
Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Met Asp Ile Asp
            820                 825                 830         
Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro
        835                 840                 845             
Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala
    850                 855                 860                 
Leu Tyr Arg Glu Ala Leu Glu Ser Ser Ala Asp Leu Glu Val Val Thr
865                 870                 875                 880 
Ser Thr Trp Val Leu Val Gly Gly Val Leu Pro Glu His Cys Ser Pro
                885                 890                 895     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            900                 905                 910         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        915                 920                 925             
Asp Leu Val Val Ser
    930             


<210> 25
<211> 2802
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS3/4A-4Bjunct-HBcAg88-141-NS3/4Ajunct-HBc142-183-
      NS3/4Ajunct-HBc1-44-NS3/4Ajunct-HBc45-87
      (nucleotide sequence)

<400> 25
atggccccca tcaccgccta cgcccagcag acccgcggcc tgctgggctg catcatcacc 60
agcctgaccg gccgcgacaa gaaccaggtg gagggcgagg tgcagatcgt gagcaccgcc 120
gcccagacct tcctggccac ctgcatcaac ggcgtgtgct ggaccgtgta ccacggcgcc 180
ggcacccgca ccatcgccag ccccaagggc cccgtgatcc agatgtacac caacgtggac 240
caggacctgg tgggctggcc cgccccccag ggcgcccgca gcctgacccc ctgcacctgc 300
ggcagcagcg acctgtacct ggtgacccgc cacgccgacg tgatccccgt gcgccgccgc 360
ggcgacggcc gcggcagcct gctgagcccc cgccccatca gctacctgaa gggcagcagc 420
ggcggccccc tgctgtgccc cgccggccac gccgtgggca tcttccgcgc cgccgtgtgc 480
acccgcggcg tggccaaggc cgtggacttc atccccgtgg agagcctgga gaccaccatg 540
cgcagccccg tgttcagcga caacagcagc ccccccgccg tgccccagag ctaccaggtg 600
gcccacctgc acgcccccac cggcagcggc aagagcacca aggtgcccgc cgcctacgcc 660
gcccagggct acaaggtgct ggtgctgaac cccagcgtgg ccgccaccat gggcttcggc 720
gcctacatga gcaaggccca cggcatcgac cccaacatcc gcaccggcgt gcgcaccatc 780
accaccggca gccccatcac ctacagcacc tacggcaagt tcctggccga cggcggctgc 840
agcggcggcg cctacgacat catcatctgc gacgagtgcc acagcaccga cgccaccagc 900
atcctgggca tcggcaccgt gctggaccag gccgagaccg ccggcgcccg cctgaccgtg 960
ctggccaccg ccaccccccc cggcagcgtg accgtgcccc accccaacat cgaggaggtg 1020
gccctgagca ccaccggcga gatccccttc tacggcaagg ccatccccct ggaggccatc 1080
aagggcggcc gccacctgat cttctgccac agcaagaaga agtgcgacga gctggccgcc 1140
aagctggtgg ccctgggcgt gaacgccgtg gcctactacc gcggcctgga cgtgagcgtg 1200
atccccacca gcggcgacgt ggtggtggtg gccaccgacg ccctgatgac cggcttcacc 1260
ggcgacttcg acagcgtgat cgactgcaac acctgcgtga cccagaccgt ggacttcagc 1320
ctggacccca ccttcaccat cgagaccatc accctgcccc aggacgccgt gagccgcacc 1380
cagcgccgcg gccgcaccgg ccgcggcaag cccggcatct accgcttcgt ggcccccggc 1440
gagcgcccca gcggcatgtt cgacagcagc gtgctgtgcg agtgctacga cgccggctgc 1500
gcctggtacg agctgacccc cgccgagacc accgtgcgcc tgcgcgccta catgaacacc 1560
cccggcctgc ccgtgtgcca ggaccacctg gagttctggg agggcgtgtt caccggcctg 1620
acccacatcg acgcccactt cctgagccag accaagcaga gcggcgagaa cctgccctac 1680
ctggtggcct accaggccac cgtgtgcgcc cgcgcccagg cccccccccc cagctgggac 1740
cagatgtgga agtgcctgat ccgcctgaag cccaccctgc acggccccac ccccctgctg 1800
taccgcctgg gcgccgtgca gaacgaggtg accctgaccc accccgtgac caagtacatc 1860
atgacctgca tgagcgccga cctggaggtg gtgaccagca cctgggtgct ggtgggcggc 1920
gtgctggccg ccctggccgc ctactgcctg agcaccggct gcgtggtgat cgtgggccgc 1980
atcgtgctga gcggcaagcc cgccatcatc cccgaccgcg aggtgctgta ccgcgagttc 2040
gacgagatgg aggagtgcag ccagcacctg ccctacatcg agcagggcta cgtgaacacc 2100
aacatgggcc tgaagttccg ccagctgctg tggttccaca tcagctgcct gaccttcggc 2160
cgcgagaccg tgatcgagta cctggtgagc ttcggcgtgt ggatccgcac cccccccgcc 2220
taccgccccc ccaacgcccc catcctgagc agcgccgacc tggaggtggt gaccagcacc 2280
tgggtgctgg tgggcggcgt gctgaccctg cccgagacca ccgtggtgcg ccgccgcggc 2340
cgcagccccc gccgccgcac ccccagcccc cgccgccgcc gcagccagag cccccgccgc 2400
cgccgcagcc agagccgcga gagccagtgc agcgccgacc tggaggtggt gaccagcacc 2460
tgggtgctgg tgggcggcgt gctgatggac atcgacccct acaaggagtt cggcgccacc 2520
gtggagctgc tgagcttcct gcccagcgac ttcttcccca gcgtgcgcga cctgctggac 2580
accgccagcg ccctgtaccg cgaggccctg gagagcagcg ccgacctgga ggtggtgacc 2640
agcacctggg tgctggtggg cggcgtgctg cccgagcact gcagccccca ccacaccgcc 2700
ctgcgccagg ccatcctgtg ctggggcgag ctgatgaccc tggccacctg ggtgggcgtg 2760
aacctggagg accccgccag ccgcgacctg gtggtgagct ag                    2802



<210> 26
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A HBcAg Fusion Protein

<400> 26
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Pro Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 27
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg Fusion Protein

<400> 27
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr Ala Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Ala Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 28
<211> 869
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg Fusion Protein

<400> 28
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Met Asp
        675                 680                 685             
Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe
    690                 695                 700                 
Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala
705                 710                 715                 720 
Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro
                725                 730                 735     
His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met
            740                 745                 750         
Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg
        755                 760                 765             
Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg
    770                 775                 780                 
Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr
785                 790                 795                 800 
Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro
                805                 810                 815     
Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr
            820                 825                 830         
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
        835                 840                 845             
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
    850                 855                 860                 
Arg Glu Ser Gln Cys
865                 


<210> 29
<211> 879
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg Fusion Protein

<400> 29
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Met Asp Ile Asp Pro Tyr Lys Glu
    690                 695                 700                 
Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe
705                 710                 715                 720 
Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu
                725                 730                 735     
Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg
            740                 745                 750         
Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val
        755                 760                 765             
Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Tyr
    770                 775                 780                 
Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp Phe His
785                 790                 795                 800 
Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr Leu Val
                805                 810                 815     
Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn
            820                 825                 830         
Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg Arg
        835                 840                 845             
Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser
    850                 855                 860                 
Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser Gln Cys
865                 870                 875                 


<210> 30
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg Fusion Protein

<400> 30
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Met Asp Ile Asp Pro Tyr Lys Glu
    690                 695                 700                 
Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe
705                 710                 715                 720 
Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu
                725                 730                 735     
Ala Leu Glu Ser Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val
            740                 745                 750         
Leu Val Gly Gly Val Leu Pro Glu His Cys Ser Pro His His Thr Ala
        755                 760                 765             
Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr
    770                 775                 780                 
Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val
785                 790                 795                 800 
Ser Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly
                805                 810                 815     
Gly Val Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu
            820                 825                 830         
Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile
        835                 840                 845             
Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr
    850                 855                 860                 
Arg Pro Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val Val
865                 870                 875                 880 
Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Thr Leu Pro Glu Thr
                885                 890                 895     
Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser
            900                 905                 910         
Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser
        915                 920                 925             
Arg Glu Ser Gln Cys
    930             


<210> 31
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS3/4A-HBcAg Fusion Protein

<400> 31
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly
 1               5                  10                  15      
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly
            20                  25                  30          
Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys
        35                  40                  45              
Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr
    50                  55                  60                  
Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp
65                  70                  75                  80  
Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr
                85                  90                  95      
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala
            100                 105                 110         
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Gly Arg Gly Ser Leu Leu
        115                 120                 125             
Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu
    130                 135                 140                 
Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys
145                 150                 155                 160 
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu
                165                 170                 175     
Glu Thr Thr Met Arg Ser Pro Val Phe Ser Asp Asn Ser Ser Pro Pro
            180                 185                 190         
Ala Val Pro Gln Ser Tyr Gln Val Ala His Leu His Ala Pro Thr Gly
        195                 200                 205             
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr
    210                 215                 220                 
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Met Gly Phe Gly
225                 230                 235                 240 
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly
                245                 250                 255     
Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly
            260                 265                 270         
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
        275                 280                 285             
Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile
    290                 295                 300                 
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Thr Val
305                 310                 315                 320 
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn
                325                 330                 335     
Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly
            340                 345                 350         
Lys Ala Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe
        355                 360                 365             
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala
    370                 375                 380                 
Leu Gly Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val
385                 390                 395                 400 
Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
                405                 410                 415     
Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
            420                 425                 430         
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu
        435                 440                 445             
Thr Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly
    450                 455                 460                 
Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly
465                 470                 475                 480 
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr
                485                 490                 495     
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val
            500                 505                 510         
Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
        515                 520                 525             
His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp
    530                 535                 540                 
Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr
545                 550                 555                 560 
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro
                565                 570                 575     
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr
            580                 585                 590         
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn
        595                 600                 605             
Glu Val Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met
    610                 615                 620                 
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly
625                 630                 635                 640 
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val
                645                 650                 655     
Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp
            660                 665                 670         
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln
        675                 680                 685             
His Leu Pro Tyr Ile Glu Gln Gly Thr Leu Pro Glu Thr Thr Val Val
    690                 695                 700                 
Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg
705                 710                 715                 720 
Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg Glu Ser
                725                 730                 735     
Gln Cys Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val
            740                 745                 750         
Gly Gly Val Leu Pro Glu His Cys Ser Pro His His Thr Ala Leu Arg
        755                 760                 765             
Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val
    770                 775                 780                 
Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp Leu Val Val Ser Ser
785                 790                 795                 800 
Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val
                805                 810                 815     
Leu Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln Leu Leu Trp
            820                 825                 830         
Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Ile Glu Tyr
        835                 840                 845             
Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro
    850                 855                 860                 
Pro Asn Ala Pro Ile Leu Ser Ser Ala Asp Leu Glu Val Val Thr Ser
865                 870                 875                 880 
Thr Trp Val Leu Val Gly Gly Val Leu Met Asp Ile Asp Pro Tyr Lys
                885                 890                 895     
Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe
            900                 905                 910         
Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg
        915                 920                 925             
Glu Ala Leu Glu Ser

<210> 32
<211> 569
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon Optimized HBcAg

<400> 32
gaattcgcac catggacatc gacccctaca aggagttcgg cgccaccgtg gagctgctga 60
gcttcctgcc cagcgacttc ttccccagcg tgagagacct gctggacacc gccagcgccc 120
tgtacagaga ggccctggag agccccgagc actgcagccc ccaccacacc gccctgagac 180
aggccatcct gtgctggggc gagctgatga ccctggccac ctgggtgggc gtgaacctgg 240
aggaccccgc cagcagagac ctggtggtga gctacgtgaa caccaacatg ggcctgaagt 300
tcagacagct gctgtggttc cacatcagct gcctgacctt cggcagagag accgtgatcg 360
agtacctggt gagcttcggc gtgtggatca gaaccccccc cgcctacaga ccccccaacg 420
cccccatcct gagcaccctg cccgagacca ccgtggtgag aagaagaggc agaagcccca 480
gaagaagaac ccccagcccc agaagaagaa gaagccagag ccccagaaga agaagaagcc 540
agagcagaga gagccagtgc tagtctaga                                   569

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A CpG containing Oligonucleotide

<400> 33
tccatgacgt tcctgacgtt								20

