                         SEQUENCE LISTING

<110>  Scil Proteins GmbH
 
<120>  MODIFIED MULTIMERIC PROTEINS BINDING VEGF-A

<130>  P31025-WO

<150>  EP11170240.3
<151>  2011-06-16

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  76
<212>  PRT
<213>  Artificial

<220>
<223>  wild-type ubiquitin

<400>  1

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  2
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF-A

<400>  2

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  3
<211>  147
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF-121

<400>  3

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  4
<211>  191
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF165

<400>  4

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  5
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF-121 HZ

<400>  5

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Cys Asp Lys Pro Arg Arg 
        115                 120     


<210>  6
<211>  165
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF165_HZ

<400>  6

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg 
                165 


<210>  7
<211>  165
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF165

<400>  7

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg 
                165 


<210>  8
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF121

<400>  8

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Cys Asp Lys Pro Arg Arg 
        115                 120     


<210>  9
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFA_MOUSE

<400>  9

Ala Pro Thr Thr Glu Gly Glu Gln Lys Ser His Glu Val Ile Lys Phe 
1               5                   10                  15      


Met Asp Val Tyr Gln Arg Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val 
            20                  25                  30          


Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro 
        35                  40                  45              


Ser Cys Val Pro Leu Met Arg Cys Ala Gly Cys Cys Asn Asp Glu Ala 
    50                  55                  60                  


Leu Glu Cys Val Pro Thr Ser Glu Ser Asn Ile Thr Met Gln Ile Met 
65                  70                  75                  80  


Arg Ile Lys Pro His Gln Ser Gln His Ile Gly Glu Met Ser Phe Leu 
                85                  90                  95      


Gln His Ser Arg Cys Glu Cys Arg Pro Lys Lys Asp Arg Thr Lys Pro 
            100                 105                 110         


Glu Asn His Cys Glu Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val 
        115                 120                 125             


Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg 
    130                 135                 140                 


Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp 
145                 150                 155                 160 


Lys Pro Arg Arg 
                


<210>  10
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFA_RAT

<400>  10

Ala Pro Thr Thr Glu Gly Glu Gln Lys Ala His Glu Val Val Lys Phe 
1               5                   10                  15      


Met Asp Val Tyr Gln Arg Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val 
            20                  25                  30          


Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro 
        35                  40                  45              


Ser Cys Val Pro Leu Met Arg Cys Ala Gly Cys Cys Asn Asp Glu Ala 
    50                  55                  60                  


Leu Glu Cys Val Pro Thr Ser Glu Ser Asn Val Thr Met Gln Ile Met 
65                  70                  75                  80  


Arg Ile Lys Pro His Gln Ser Gln His Ile Gly Glu Met Ser Phe Leu 
                85                  90                  95      


Gln His Ser Arg Cys Glu Cys Arg Pro Lys Lys Asp Arg Thr Lys Pro 
            100                 105                 110         


Glu Asn His Cys Glu Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val 
        115                 120                 125             


Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg 
    130                 135                 140                 


Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp 
145                 150                 155                 160 


Lys Pro Arg Arg 
                


<210>  11
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF_RABBIT

<400>  11

Ala Pro Met Ala Glu Glu Gly Asp Asn Lys Pro His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Glu Val Tyr Arg Arg Ser Tyr Cys Gln Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Val Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Ser Leu Glu Cys Val Pro Thr Glu Glu Phe Asn Val Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys 
            100                 105         


<210>  12
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFA_DOG

<400>  12

Ala Pro Met Ala Gly Gly Glu His Lys Pro His Glu Val Val Lys Phe 
1               5                   10                  15      


Met Asp Val Tyr Gln Arg Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val 
            20                  25                  30          


Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro 
        35                  40                  45              


Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly 
    50                  55                  60                  


Leu Glu Cys Val Pro Thr Glu Glu Phe Asn Ile Thr Met Gln Ile Met 
65                  70                  75                  80  


Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu 
                85                  90                  95      


Gln His Ser Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln 
            100                 105                 110         


Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val 
        115                 120                 125             


Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg 
    130                 135                 140                 


Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp 
145                 150                 155                 160 


Lys Pro Arg Arg 
                


<210>  13
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFA_CAVPO

<400>  13

Ala Pro Met Ala Glu Gly Glu Gln Lys Pro Arg Glu Glu Val Lys Phe 
1               5                   10                  15      


Met Asp Val Tyr Lys Arg Ser Tyr Cys Arg Pro Ile Glu Met Leu Val 
            20                  25                  30          


Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro 
        35                  40                  45              


Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Ser 
    50                  55                  60                  


Leu Glu Cys Val Pro Thr Glu Glu Phe Asn Ile Thr Met Gln Ile Met 
65                  70                  75                  80  


Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu 
                85                  90                  95      


Gln His Ser Lys Cys Glu Cys Arg Pro Lys Lys Glu Lys Ala Arg Gln 
            100                 105                 110         


Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val 
        115                 120                 125             


Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Arg Asn Thr Asp Ser Arg 
    130                 135                 140                 


Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp 
145                 150                 155                 160 


Lys Pro Arg Arg 
                


<210>  14
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  VEGF-A binding protein 40401

<400>  14

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Gly Gly Gly Ile Gly Met Gln Ile Phe Val Ala Thr Asp Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Arg Asp Thr Val Ser Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  15
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  heterodimeric ubiquitin


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (138)..(142)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Gln Ile Phe Val Xaa Thr Xaa Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Xaa Thr Xaa Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Xaa Xaa Xaa Xaa Xaa Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala 
145                 150         


<210>  16
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  59517_1321-B2

<400>  16

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Leu Thr Ser Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Ile 
            100                 105                 110         


Asp Val Ala Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu 
        115                 120                 125             


Val Leu Arg Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Ser 
    130                 135                 140                 


Thr Asn Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr 
145                 150                 155                 160 


Ile Glu 
        


<210>  17
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  59649_1321-D10

<400>  17

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Leu Thr Arg Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Thr Ser Lys Ser Ser Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  18
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  60423_1325-G10

<400>  18

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Arg Thr Arg Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Gln Asn Gln Phe Gln Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  19
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  60323_1325-E4

<400>  19

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Asp Thr Glu Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Glu Gln Leu Asn Trp Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  20
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  40401_1211-A1

<400>  20

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Gly Gly Gly Ile Gly Met Gln Ile Phe Val Ala Thr Asp Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Arg Asp Thr Val Ser Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  21
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  60397_1325-B9

<400>  21

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Ala Thr Asp Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Lys Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Asn Asp Glu Ser Ala Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  22
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  59507_1321-E1

<400>  22

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Ser Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Ser Thr Phe Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Ile Asp Trp Ser Gln Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  23
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  59987_1323-E7

<400>  23

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Glu 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Gln Ile Phe Val Ser Thr Arg Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Arg Lys His Tyr Thr Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  24
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  59603_1321-E7

<400>  24

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Glu 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Gly Ile Gly Met Arg Ile Phe Val Tyr Thr Ala Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Ser Glu Lys Lys Lys Leu His Leu Val Leu Arg Leu 
145                 150                 155                 160 


Arg Ala Ala 
            


<210>  25
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  40703_1212-E8

<400>  25

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Glu Trp Met 
    50                  55                  60                  


Pro Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ile Gly Met Gln Ile Phe Val His Thr Met 
                85                  90                  95      


Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu 
            100                 105                 110         


Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln 
        115                 120                 125             


Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu 
    130                 135                 140                 


Ser Asp Tyr Asn Ile Thr Leu Arg Pro Pro Leu His Leu Val Leu Arg 
145                 150                 155                 160 


Leu Arg Ala Ala 
                


<210>  26
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  39675_1207-B10

<400>  26

Met Gln Ile Phe Val Phe Thr Gln Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Tyr Ala Trp 
    50                  55                  60                  


Ser Pro Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Ile Gly Met 
65                  70                  75                  80  


Gln Ile Phe Val Ser Thr Tyr Thr Gly Lys Thr Ile Thr Leu Glu Val 
                85                  90                  95      


Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys 
            100                 105                 110         


Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln 
        115                 120                 125             


Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Ala Val Arg Thr 
    130                 135                 140                 


Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala 
145                 150                 155 


<210>  27
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  39975_1208-G4

<400>  27

Met Gln Ile Phe Val Phe Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Val Pro Trp 
    50                  55                  60                  


Gln Tyr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Ile Gly Met 
65                  70                  75                  80  


Gln Ile Phe Val Tyr Thr Met Thr Gly Lys Thr Ile Thr Leu Glu Val 
                85                  90                  95      


Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys 
            100                 105                 110         


Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln 
        115                 120                 125             


Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Glu Gln Ser Pro 
    130                 135                 140                 


Gln Leu His Leu Val Leu Arg Leu Arg Ala Ala 
145                 150                 155 


<210>  28
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  38505_1201-B1

<400>  28

Met Gln Ile Phe Val Phe Thr Ser Thr Gly Glu Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Pro Pro Trp 
    50                  55                  60                  


Ala Tyr Leu His Leu Val Leu Arg Leu Arg Ala Ala Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ile Gly Met Gln Ile Phe Val Thr Thr Asn Thr Gly Lys Thr Ile 
                85                  90                  95      


Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys 
            100                 105                 110         


Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp 
        115                 120                 125             


Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile 
    130                 135                 140                 


Gly Asn His Gln Trp Leu His Leu Val Leu Arg Leu Arg Ala Ala 
145                 150                 155                 


<210>  29
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  38943_1203-D4

<400>  29

Met Gln Ile Phe Val Phe Thr Ser Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Pro Ser Trp 
    50                  55                  60                  


Ala Tyr Leu His Leu Val Leu Arg Leu Arg Ala Ala Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ile Gly Met Gln Ile Phe Val Trp Thr Asp 
                85                  90                  95      


Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu 
            100                 105                 110         


Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln 
        115                 120                 125             


Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu 
    130                 135                 140                 


Ser Asp Tyr Asn Ile Ser Asp Thr Val Leu Leu His Leu Val Leu Arg 
145                 150                 155                 160 


Leu Arg Ala Ala 
                


<210>  30
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  40685_1212-D11

<400>  30

Met Gln Ile Phe Val Phe Thr Ala Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Pro Ser Trp 
    50                  55                  60                  


Ala Tyr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Ile Gly Met 
65                  70                  75                  80  


Gln Ile Phe Val Gln Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu Val 
                85                  90                  95      


Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys 
            100                 105                 110         


Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln 
        115                 120                 125             


Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Ser Asp Thr Ile 
    130                 135                 140                 


Ser Leu His Leu Val Leu Arg Leu Arg Ala Ala 
145                 150                 155 


<210>  31
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  31

Gly Ile Gly 
1           


<210>  32
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  32

Ser Gly Gly Gly Gly 
1               5   


<210>  33
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  33

Ser Gly Gly Gly Gly Ile Gly 
1               5           


<210>  34
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  34

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Gly 
1               5                   10          


<210>  35
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  35

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  36
<211>  171
<212>  PRT
<213>  Artificial

<220>
<223>  40401 homo-dimer

<400>  36

Met Gln Ile Phe Val Tyr Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Asp Val Ala 
    50                  55                  60                  


Glu Tyr Leu Gly Ile Ser Trp Met Pro Ala Leu His Leu Val Leu Arg 
65                  70                  75                  80  


Leu Arg Gly Gly Gly Ile Gly Met Gln Ile Phe Val Tyr Thr Asp Thr 
                85                  90                  95      


Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 
            100                 105                 110         


Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 
        115                 120                 125             


Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 
    130                 135                 140                 


Asp Tyr Asn Ile Asp Val Ala Glu Tyr Leu Gly Ile Ser Trp Met Pro 
145                 150                 155                 160 


Ala Leu His Leu Val Leu Arg Leu Arg Ala Ala 
                165                 170     


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  insert

<400>  37

Asp Val Ala Glu Tyr Leu Gly Ile 
1               5               


<210>  38
<211>  76
<212>  PRT
<213>  Artificial

<220>
<223>  Pre-modified ubiquitin monomer

<400>  38

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


