                         SEQUENCE LISTING

<110>  Istituto Nazionale di Genetica Molecolare - INGM
 
<120>  BIOMARKERS FOR AUTOIMMUNE LIVER DISEASES AND USES THEREOF

<130>  PCT117423

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val Ser Asp Thr 
1               5                   10                  15      


Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr 
            20                  25                  30          


Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro Ala 
        35                  40                  45              


Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile 
    50                  55                  60                  


Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg 
65                  70                  75                  80  


Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser 
                85                  90                  95      


Thr 
    


<210>  2
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Asn Trp Gly Cys Tyr Gly Asn Ile Gln Ser Leu Asp Thr Pro Gly 
1               5                   10                  15      


Ala Ser Cys Gly Ile Gly Arg Arg His Gly Leu Asn Tyr Cys Gly Val 
            20                  25                  30          


Arg Ala Ser Glu Arg Leu Ala Glu Ile Asp Met Pro Tyr Leu Leu Lys 
        35                  40                  45              


Tyr Gln Pro Met Met Gln Thr Ile Gly Gln Lys Tyr Cys Met Asp Pro 
    50                  55                  60                  


Ala Val Ile Ala Gly Val Leu Ser Arg Lys Ser Pro Gly Asp Lys Ile 
65                  70                  75                  80  


Leu Val Asn Met Gly Asp Arg Thr Ser Met Val Gln Asp Pro Gly Ser 
                85                  90                  95      


Gln Ala Pro Thr Ser Trp Ile Ser Glu Ser Gln Val Ser Gln Thr Thr 
            100                 105                 110         


Glu Val Leu Thr Thr Arg Ile Lys Glu Ile Gln Arg Arg Phe Pro Thr 
        115                 120                 125             


Trp Thr Pro Asp Gln Tyr Leu Arg Gly Gly Leu Cys Ala Tyr Ser Gly 
    130                 135                 140                 


Gly Ala Gly Tyr Val Arg Ser Ser Gln Asp Leu Ser Cys Asp Phe Cys 
145                 150                 155                 160 


Asn Asp Val Leu Ala Arg Ala Lys Tyr Leu Lys Arg His Gly Phe 
                165                 170                 175 


<210>  3
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu Asp Leu Asn 
1               5                   10                  15      


Lys Glu Ile Met Asn Glu Leu Gly Val Thr Val Val Gly Asp Ile Ile 
            20                  25                  30          


Ala Ile Leu Lys His Ala Lys Val Val His Arg Gln Asp Met Cys Lys 
        35                  40                  45              


Ala Ala Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu Ala Gly Glu 
    50                  55                  60                  


Ile Arg Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr Asn Ser Leu 
65                  70                  75                  80  


Asn His Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro Asp Thr Ser 
                85                  90                  95      


Thr Ser Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala Ala Lys Ser 
            100                 105                 110         


Ala Lys Ala Thr Ala Ala Leu Ala Arg Arg Glu Glu Glu Ser Leu Ala 
        115                 120                 125             


Val Pro Ala Lys Arg Arg Arg Val Thr Ala Glu Met Glu Gly Lys Tyr 
    130                 135                 140                 


Val Ile Asn Met Pro Lys Gly Thr Thr Pro Arg Thr Arg Lys Ile Leu 
145                 150                 155                 160 


Glu Gln Gln Gln Ala Ala Lys Gly Leu His Arg Thr Ser Val Phe Asp 
                165                 170                 175     


Arg Leu Gly Ala Glu Thr Lys Ala Asp Thr Thr Thr Gly Ser Lys Pro 
            180                 185                 190         


Thr Gly Val Phe Ser Arg Leu Gly Ala Thr Pro Glu Thr Asp Glu Asp 
        195                 200                 205             


Leu Ala Trp Asp Ser Asp Asn Asp Ser Ser Ser Ser Val Leu Gln Tyr 
    210                 215                 220                 


Ala Gly Val Leu Lys Lys Leu Gly Arg Gly Pro Ala Lys 
225                 230                 235         


<210>  4
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His Tyr 
1               5                   10                  15      


Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu Cys 
            20                  25                  30          


Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val Met 
        35                  40                  45              


Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys Cys 
    50                  55                  60                  


Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
65                  70                  75                  


<210>  5
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  5

His Glu Ala His Lys Thr Ser Leu Ser Ser Trp Lys His Asp Gln Asp 
1               5                   10                  15      


Trp Ala Asn Val Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Arg Val 
            20                  25                  30          


Lys Gly Ile Tyr Tyr Arg Asn Ala Asp Ile Cys Ser Arg His Arg Val 
        35                  40                  45              


Thr Ser Ala Gly Leu Thr Leu Gln Asp Leu Gln Leu Trp Cys Asn Leu 
    50                  55                  60                  


Arg Ser Val Ala Arg Gly Gln Ile Pro Ser Thr Leu 
65                  70                  75      


<210>  6
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Val Ala Glu Phe His Met Ser Leu Thr Val Ser Cys Pro Asp Pro 
1               5                   10                  15      


Thr Pro Ser Thr Asp Pro Gln Gly Arg His Asn Arg Glu Pro Ile Leu 
            20                  25                  30          


Gly Arg Asp Asp Asp Phe Met Cys Lys Gln Val Lys Phe Arg Met Cys 
        35                  40                  45              


Val Val Gly Arg Asp Gly Asn Ala Gln Ser Ser Val Arg Tyr Thr Gly 
    50                  55                  60                  


Pro Leu Tyr Arg Arg Lys Ile Arg Thr Glu Phe Leu Phe Val Val Phe 
65                  70                  75                  80  


Leu Leu Glu Thr Arg Glu Leu Lys Pro Gln Val Asn Lys Asn Val Gln 
                85                  90                  95      


Gly Thr Arg Pro Ser 
            100     


<210>  7
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Phe Val Leu Thr Tyr Met Asp Pro Lys Gly Glu Val Lys Lys 
1               5                   10                  15      


Thr His Leu His Leu Ala Ser Phe Ser Pro Ser Ser Glu Val Ser Cys 
            20                  25                  30          


Phe Thr Asn Lys Ala Gln Ala Lys Asn Cys Ser Val Glu Gly Cys Pro 
        35                  40                  45              


Ser Glu Trp Ser Ser Pro Arg Asn Leu Arg Ser Thr Lys Ser Ile Gly 
    50                  55                  60                  


Thr Ile Arg Ala Thr Gly Gly Cys Leu Cys Ser Gly Thr Val Leu His 
65                  70                  75                  80  


Phe Pro Ile Pro Gly Ser Ala Ser Gln Ala Ser Leu 
                85                  90          


<210>  8
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Thr Gly Ile Leu Ile Cys Met Thr Lys Asn Leu Glu Ser Val His 
1               5                   10                  15      


Ser Ile Val Leu Ala His Ser Cys Tyr His His Glu Asn Lys Pro Arg 
            20                  25                  30          


Pro Asp Cys Cys Phe Gln Gln Lys Ile Arg Asp Thr Lys Ser Lys Val 
        35                  40                  45              


Glu Leu Pro Arg His Ala His Ala Arg Leu Thr Asn Pro Gln Leu Thr 
    50                  55                  60                  


His Arg Ser Met Lys Ile Asn Asp Cys Cys Ile Lys Pro Leu Arg Phe 
65                  70                  75                  80  


Gly Val Thr Cys Tyr Ala Ala Phe Cys Asp Asn Asn 
                85                  90          


<210>  9
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Arg Glu Glu Glu Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val 
1               5                   10                  15      


Leu Glu Val Phe Pro Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn 
        35                  40                  45              


Ile Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe 
    50                  55                  60                  


Asn Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe 
65                  70                  75                  80  


Cys Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu 
                85                  90                  95      


Gln Met His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala 
            100                 105                 110         


Asn Phe Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile 
        115                 120                 125             


Cys Gln Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly 
    130                 135                 140                 


Lys Asp Gly Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro 
145                 150                 155                 160 


Ala Asn Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe Trp Cys 
                165                 170                 175     


Gln Ala Ala Asn Asn Ala Asn Val Gln His Ser Ala Leu Thr Val Val 
            180                 185                 190         


Pro Pro Gly Gly Asp Gln Lys Met Glu Asp Trp Gln Gly Pro Leu Glu 
        195                 200                 205             


Ser Pro Ile Leu Ala Leu Pro Leu Tyr Arg Ser Thr Arg Arg Leu Ser 
    210                 215                 220                 


Glu Glu Glu Phe Gly Gly Phe Arg Ile Gly Asn Gly Glu 
225                 230                 235         


<210>  10
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn Leu 
1               5                   10                  15      


Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys Trp 
            20                  25                  30          


Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln Met 
        35                  40                  45              


His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn Phe 
    50                  55                  60                  


Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys Gln 
65                  70                  75                  80  


Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys Asp 
                85                  90                  95      


Gly Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala Asn 
            100                 105                 110         


Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe 
        115                 120                 


<210>  11
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr 
1               5                   10                  15      


His Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala 
            20                  25                  30          


Ala Gly Ala Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn 
        35                  40                  45              


Leu Arg Pro Asn Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile 
    50                  55                  60                  


Arg Ser Phe Thr Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr 
65                  70                  75                  80  


Gly Glu Leu Arg Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg 
                85                  90                  95      


Val Gln Cys Phe Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr 
            100                 105                 110         


Pro Gln Gln Asp Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu 
        115                 120                 125             


Val Arg Arg His Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys 
    130                 135                 140                 


Arg Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp 
145                 150                 155                 160 


Phe Ala Val Arg Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg 
                165                 170                 175     


Gln Asp Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys 
            180                 185                 190         


Ser Arg Val Phe Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly 
        195                 200                 205             


Arg Val Arg Thr Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp 
    210                 215                 220                 


Phe Leu Phe Thr Gly His Met His Phe Gly Glu Ala Arg 
225                 230                 235         


<210>  12
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Phe Gly Val Leu Glu Gly Ala Gln Ala Asn Ser Glu Asn Trp Ile 
1               5                   10                  15      


Ala Pro Ser Gly Pro Trp Ala Leu Gly Leu Trp Ser Ser Leu Tyr Phe 
            20                  25                  30          


Leu Leu Phe Ser Thr Leu Glu Gly Arg Gly Gly Arg Val Leu Ser Gln 
        35                  40                  45              


Ser Cys Ser Met Ala Val Ala Ala Ala Ser Trp Ile Ser Arg Glu Asn 
    50                  55                  60                  


Ala Arg Ser Val Lys Arg Ser Tyr Met Gln Ser Ser Pro Gln Arg Pro 
65                  70                  75                  80  


Lys Glu Pro Arg Asn Gln Arg Thr Ser His Thr Thr Pro Val Cys 
                85                  90                  95  


<210>  13
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Gly Phe Thr Ala Leu His Trp Ala Ala Lys Ser Gly Asp Gly Glu 
1               5                   10                  15      


Met Ala Leu Gln Leu Val Glu Val Ala Arg Arg Ser Gly Ala Pro Val 
            20                  25                  30          


Asp Val Asn Ala Arg Ser His Gly Gly Tyr Thr Pro Leu His Leu Ala 
        35                  40                  45              


Ala Leu His Gly His Glu Asp Ala Ala Val Leu Leu Val Val Arg Leu 
    50                  55                  60                  


Gly Ala Gln Val His Val Arg Asp His Ser Gly Arg Arg Ala Tyr Gln 
65                  70                  75                  80  


Tyr Leu Arg Pro Gly Ser Ser Tyr Ala Leu Arg Arg Leu Leu Gly Asp 
                85                  90                  95      


Pro Gly Leu Arg Gly Thr Thr Glu Pro Asp Ala Thr Gly Gly Gly Ser 
            100                 105                 110         


Gly Ser Leu Ala Ala Arg Arg Pro Val Gln Val Ala Ala Thr Ile Leu 
        115                 120                 125             


Ser Ser Thr Thr Ser Ala Phe Leu Gly Val Leu Ala Asp Asp Leu Met 
    130                 135                 140                 


Leu Gln Asp Leu Ala Arg Gly Leu Lys Lys Ser Ser Ser Phe Ser Lys 
145                 150                 155                 160 


Phe Leu Ser Ala Ser Pro Met Ala Pro Arg Lys Lys Thr Lys Ile Arg 
                165                 170                 175     


Gly Gly Leu Pro Ala Phe Ser Glu Ile Ser Arg Arg Pro Thr Pro Gly 
            180                 185                 190         


Pro Leu Ala Gly Leu Val Pro Ser Phe Pro Pro Thr Thr 
        195                 200                 205 


<210>  14
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Leu Ile Val Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Leu 
1               5                   10                  15      


Val Arg Asp Ser His Gly Lys Gly Ile Pro Asn Ala Ile Ile Ser Val 
            20                  25                  30          


Glu Gly Ile Asn His Asp Ile Arg Thr Ala Asn Asp Gly Asp Tyr Trp 
        35                  40                  45              


Arg Leu Leu Asn Pro Gly Glu Tyr Val Val Thr Ala Lys Ala Glu Gly 
    50                  55                  60                  


Phe Thr Ala Ser Thr Lys Asn Cys Met Val Gly Tyr Asp Met Gly Ala 
65                  70                  75                  80  


Thr Arg Cys Asp Phe Thr Leu Ser Lys Thr Asn Met Ala Arg Ile Arg 
                85                  90                  95      


Glu Ile Met Glu Lys Phe Gly Lys Gln Pro Val Ser Leu Pro Ala Arg 
            100                 105                 110         


Arg Leu Lys Leu Arg Gly Gln Lys Arg Arg Gln Arg Gly 
        115                 120                 125 


<210>  15
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ser Leu Ser Pro Thr Lys Tyr Asn Leu Leu Glu Leu Lys Glu Ser 
1               5                   10                  15      


Cys Ile Arg Asn Gln Asp Cys Glu Thr Gly Cys Cys Gln Arg Ala Pro 
            20                  25                  30          


Asp Asn Cys Glu Ser His Cys Ala Glu Lys Gly Ser Glu Gly Ser Leu 
        35                  40                  45              


Cys Gln Thr Gln Val Phe Phe Gly Gln Tyr Arg Ala Cys Pro Cys Leu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Ile Tyr Ser Lys Asn Glu Lys Trp Leu Ser Ile 
65                  70                  75                  80  


Ala Tyr Gly Arg Cys Gln Lys Ile Gly Arg Gln Lys Leu Ala Lys Lys 
                85                  90                  95      


Met Phe Phe 
            


<210>  16
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gln Leu Glu Leu Ile Asp Leu Ser Ser Asn Pro Phe His Cys Asp 
1               5                   10                  15      


Cys Gln Leu Leu Pro Leu His Arg Trp Leu Thr Gly Leu Asn Leu Arg 
            20                  25                  30          


Val Gly Ala Thr Cys Ala Thr Pro Pro Asn Ala Arg Gly Gln Arg Val 
        35                  40                  45              


Lys Ala Ala Ala Ala Val Phe Glu Asp Cys Pro Gly Trp Ala Ala Arg 
    50                  55                  60                  


Lys Ala Lys Arg Thr Pro Ala Ser Arg Pro Ser Ala Arg Arg Thr Pro 
65                  70                  75                  80  


Ile Lys Gly Arg Gln Cys Gly Ala Asp Lys Val Gly His Gly Ala Gly 
                85                  90                  95      


Gly Val 
        


<210>  17
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Glu Ala Gly Gly Ser Cys Leu Arg Trp Glu Pro His Cys Gln Gln 
1               5                   10                  15      


Pro Leu Pro Asp Arg Val Pro Ser Thr Ala Ile Leu Pro Pro Arg Leu 
            20                  25                  30          


Asn Gly Pro Trp Ile Ser Thr Gly Cys Glu Val Arg Pro Gly Pro Glu 
        35                  40                  45              


Phe Leu Thr Arg Ala Tyr Thr Phe Tyr Pro Ser Arg Leu Phe Arg Ala 
    50                  55                  60                  


His Gln Phe Tyr Tyr Glu Asp Pro Phe Cys Gly Glu Pro Ala His Ser 
65                  70                  75                  80  


Leu Leu Val Lys Gly Lys Val Arg Leu Arg Arg Ala Ser Trp Val Thr 
                85                  90                  95      


Arg Gly Ala Thr Glu Ala Asp Tyr His Leu His Lys Val Gly Ile Val 
            100                 105                 110         


<210>  18
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Thr Lys Leu Val Thr Cys Pro Ala Pro Arg Gln Phe Ala Val Gly 
1               5                   10                  15      


Ala Phe Thr Ala Ala Gly Arg Ala Trp Leu Phe Ala Pro Ser Leu Gly 
            20                  25                  30          


Ala Ser Phe Ser Lys Leu Arg Ser Gln Gln Arg Ser Arg Asp Phe Arg 
        35                  40                  45              


Gly Arg Leu Phe Leu Arg Ala Glu Arg Arg Ala Gly Gly Phe Thr Ser 
    50                  55                  60                  


<210>  19
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg Gln Thr Gly 
1               5                   10                  15      


Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser Thr Gly Tyr 
            20                  25                  30          


Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu 
        35                  40                  45              


Tyr Tyr Asp Ser Tyr Thr Ser Ser Val Val Leu Glu Ser Gly Ile Ser 
    50                  55                  60                  


Pro Gly Lys Tyr Asp Thr Tyr Gly Ser Thr Arg Lys Asn Leu Arg Met 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Trp Asp Gly His Ser Asp Ser Asp Pro Pro Tyr Thr Thr Leu Lys 
            100                 105                 110         


Thr Cys Leu Val Ala Ala Ser Pro Arg Glu Glu Gly Met Arg Trp Ala 
        115                 120                 125             


Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ile Pro Ala Pro Pro Thr 
    130                 135                 140                 


Val Phe Cys Ala Arg Asp His Phe Leu Val Glu Trp Asp Leu Ser Phe 
145                 150                 155                 160 


Glu Arg Ile Phe Tyr Ser Phe Ser Ser Gly Pro Phe Pro Ser Lys Ala 
                165                 170                 175     


Pro Glu Arg Lys Ala Cys Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg 
            180                 185                 190         


Met Lys Ser Val Thr Arg Pro Thr Gly Ser Ser Ala Glu Ile Thr Cys 
        195                 200                 205             


Asp Leu Thr Val Ile Asn Ala Val Tyr Ile His Trp Tyr Leu Gln Gln 
    210                 215                 220                 


Glu Gly Lys Thr Pro Gln His Leu Leu His Tyr Asp Val 
225                 230                 235         


<210>  20
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Gly Val Thr Gln Thr Pro Lys Phe His Val Leu Lys Thr Gly Gln 
1               5                   10                  15      


Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His Glu Tyr Met Tyr 
            20                  25                  30          


Arg Tyr Arg Gln Asp Pro Gly Lys Gly Leu Arg Leu Ile Tyr Tyr Ser 
        35                  40                  45              


Val Ala Ala Ala Leu Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr Asn 
    50                  55                  60                  


Val Ser Arg Ser Asn Thr Glu Asp Phe Pro Leu Lys Leu Glu Ser Ala 
65                  70                  75                  80  


Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser Thr 
                85                  90                  95      


Ala Leu Gln Gly Cys Leu Leu Ser Ala His Lys Gly Lys Gly Arg Cys 
            100                 105                 110         


Cys Pro Pro Pro Pro Pro Lys Thr Gln Gly Cys Pro Val Gln Arg Ser 
        115                 120                 125             


Leu His Gln Glu Pro Trp Asn Pro Glu Trp Pro Gln Val Ala Arg Thr 
    130                 135                 140                 


Val 
145 


<210>  21
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Lys Val Thr Gln Thr Pro Gly His Leu Val Lys Gly Lys Gly Gln 
1               5                   10                  15      


Lys Thr Lys Met Asp Cys Thr Pro Glu Lys Gly His Thr Phe Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Asn Gln Asn Lys Glu Phe Met Leu Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Gln Val Leu Gln Glu Thr Glu Met His Lys Lys Arg Phe 
    50                  55                  60                  


Ser Ser Gln Cys Pro Lys Asn Ala Pro Cys Ser Leu Ala Ile Leu Ser 
65                  70                  75                  80  


Ser Glu Pro Gly Asp Thr Ala Leu Tyr Leu Cys Ala Ser Ser Gln Ser 
                85                  90                  95      


Thr Ala Leu Lys Cys Gln Phe Leu Leu Ala His Lys Leu Val Thr Asp 
            100                 105                 110         


Pro Ala Gln Glu Ala Gly Asp Val Leu Gly Trp Lys Gly Val Thr Glu 
        115                 120                 125             


Asn Asn Trp Ser Gln Leu Lys Pro Gln Cys Asn Leu Thr Gln Gly 
    130                 135                 140             


<210>  22
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Asp Lys Met Arg Met Gln Arg Ile Lys Val Cys Glu Lys Arg Pro 
1               5                   10                  15      


Ser Ile Asp Leu Cys Ile His His Cys Ser Tyr Phe Gln Lys Cys Glu 
            20                  25                  30          


Thr Asn Lys Ile Cys Cys Ser Ala Phe Cys Gly Asn Ile Cys Met Ser 
        35                  40                  45              


Ile Leu 
    50  


<210>  23
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Leu Leu Met Tyr Gln Gln His Thr Ser His Tyr Asp Leu Glu Arg 
1               5                   10                  15      


Lys Gly Gly Tyr Leu Met Leu Ser Phe Ile Asp Phe Cys Pro Phe Ser 
            20                  25                  30          


Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gln Arg Tyr Thr Arg Gln 
        35                  40                  45              


Glu Arg Tyr Arg Ala Arg Pro Pro Arg Val Leu Glu Arg Ser Gly Phe 
    50                  55                  60                  


His Asn Glu Asn Ser Leu Ala Ile Tyr Gln Gly Leu Val Tyr Tyr Leu 
65                  70                  75                  80  


Leu Trp Leu His Ser Val Tyr Asp Lys Pro Tyr Ala Asp Pro Val His 
                85                  90                  95      


Asp Pro Thr Trp Arg Trp Trp Ala Asn Asn Lys Gln Asp Gln Asp Tyr 
            100                 105                 110         


Tyr Phe Phe Leu Ala Ser Asn Trp Arg Ser Ala Gly Gly Val Ser Ile 
        115                 120                 125             


Glu Met Asp Ser Tyr Glu Lys Ile Tyr Asn Leu Glu Ser Ala Tyr Glu 
    130                 135                 140                 


Leu Pro Glu Arg Ile Phe Leu Asp Lys Gly Thr Glu Tyr Ser Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ser Ala Gln Gly His Ser Phe Arg Thr Gln Ser Glu Leu 
                165                 170                 175     


Gly Thr Ala Phe Gln Leu His Ser Gln Val Asp Val Gly Val Val Leu 
            180                 185                 190         


Ala Asp Pro Gly Cys Ile Glu Ala Ser Val Lys Gln Glu Val Leu Ile 
        195                 200                 205             


Asn Arg Asn Ser Val Leu Phe Ser Ile Thr Leu Lys Asp Lys Lys Leu 
    210                 215                 220                 


Cys Tyr Asp Gln Gly Ile Ser Gly His His Leu Met Glu 
225                 230                 235         


<210>  24
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Leu Leu Met Tyr Gln Gln His Thr Ser His Tyr Asp Leu Glu Arg 
1               5                   10                  15      


Lys Gly Gly Tyr Leu Met Leu Ser Phe Ile Asp Phe Cys Pro Phe Ser 
            20                  25                  30          


Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gln Arg Tyr Thr Arg Gln 
        35                  40                  45              


Glu Arg Tyr Arg Ala Arg Pro Pro Arg Val Leu Glu Arg Ser Gly Phe 
    50                  55                  60                  


His Asn Glu Asn Ser Leu Ala Ile Tyr Gln Gly Leu Val Tyr Tyr Leu 
65                  70                  75                  80  


Leu Trp Leu His Ser Val Tyr Asp Lys Pro Tyr Ala Asp Pro Val His 
                85                  90                  95      


Asp Pro Thr Trp Arg Trp Trp Ala Asn Asn Lys Gln Asp Gln Asp Tyr 
            100                 105                 110         


Tyr Phe Phe Leu Ala Ser Asn Trp Arg Ser Ala Gly Gly Val Ser Ile 
        115                 120                 125             


Glu Met Asp Ser Tyr Glu Lys Ile Tyr Asn Leu Glu Ser Ala Tyr Glu 
    130                 135                 140                 


Leu Pro Glu Arg Ile Phe Leu Asp Lys Gly Thr Glu Tyr Ser Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ser Ala Gln Gly His Ser Phe Arg Thr Gln Ser Glu Leu 
                165                 170                 175     


Gly Thr Ala Phe Gln Leu His Ser Gln Val Asp Val Gly Val Val Leu 
            180                 185                 190         


Ala Asp Pro Gly Cys Ile Glu Ala Ser Val Lys Gln Glu Val Leu Ile 
        195                 200                 205             


Asn Arg Asn Ser Val Leu Phe Ser Ile Thr Leu Lys Asp Lys Lys Leu 
    210                 215                 220                 


Cys Tyr Asp Gln Gly Ile Ser Gly His His Leu Met Glu 
225                 230                 235         


<210>  25
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Val Glu Glu Leu Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro 
1               5                   10                  15      


Asp Asn Ala Phe Gln Ser Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu 
            20                  25                  30          


Asp Asn Thr Asn Leu Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val 
        35                  40                  45              


Thr Thr Leu Lys His Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu 
    50                  55                  60                  


Pro Ser Asn Phe Pro Phe Asp Ser Leu Glu Thr Leu Ala Leu Thr Asn 
65                  70                  75                  80  


Asn Pro Trp Lys Cys Thr Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu 
                85                  90                  95      


Glu Ala Lys Ala Ser Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys 
            100                 105                 110         


Phe Lys Gly Gln His Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys 
        115                 120                 125             


Phe Pro Thr Lys Arg Ser Lys Lys Ala Gly Arg His 
    130                 135                 140 


