                         SEQUENCE LISTING

<110>  OPKO CURNA LLC
 
<120>  TREATMENT OF FRATAXIN (FXN) RELATED DISEASES BY INHIBITION OF 
       NATURAL ANTISENSE TRANSCRIPT TO FXN

<130>  FXN

<140>  US61/4947928
<141>  2011-06-09

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  7176
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctccctt gggtcagggg tcctggttgc actccgtgct ttgcacaaag caggctctcc       60

atttttgtta aatgcacgaa tagtgctaag ctgggaagtt cttcctgagg tctaacctct      120

agctgctccc ccacagaaga gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc      180

cagcgctgga gggcggagcg ggcggcagac ccggagcagc atgtggactc tcgggcgccg      240

cgcagtagcc ggcctcctgg cgtcacccag cccagcccag gcccagaccc tcacccgggt      300

cccgcggccg gcagagttgg ccccactctg cggccgccgt ggcctgcgca ccgacatcga      360

tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt ggcctcaacc agatttggaa      420

tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa tctggaactt tgggccaccc      480

aggctctcta gatgagacca cctatgaaag actagcagag gaaacgctgg actctttagc      540

agagtttttt gaagaccttg cagacaagcc atacacgttt gaggactatg atgtctcctt      600

tgggagtggt gtcttaactg tcaaactggg tggagatcta ggaacctatg tgatcaacaa      660

gcagacgcca aacaagcaaa tctggctatc ttctccatcc aggtatgtag tggacctaag      720

cgttatgact ggactgggaa aaactgggtg tactcccacg acggcgtgtc cctccatgag      780

ctgctggccg cagagctcac taaagcctta aaaaccaaac tggacttgtc ttccttggcc      840

tattccggaa aagatgcttg atgcccagcc ccgttttaag gacattaaaa gctatcaggc      900

caagacccca gcttcattat gcagctgagg tctgtttttt gttgttgttg ttgtttattt      960

tttttattcc tgcttttgag gacagttggg ctatgtgtca cagctctgta gaaagaatgt     1020

gttgcctcct accttgcccc caagttctga tttttaattt ctatggaaga ttttttggat     1080

tgtcggattt cctccctcac atgatacccc ttatctttta taatgtctta tgcctatacc     1140

tgaatataac aacctttaaa aaagcaaaat aataagaagg aaaaattcca ggagggaaaa     1200

tgaattgtct tcactcttca ttctttgaag gatttactgc aagaagtaca tgaagagcag     1260

ctggtcaacc tgctcactgt tctatctcca aatgagacac attaaagggt agcctacaaa     1320

tgttttcagg cttctttcaa agtgtaagca cttctgagct ctttagcatt gaagtgtcga     1380

aagcaactca cacgggaaga tcatttctta tttgtgctct gtgactgcca aggtgtggcc     1440

tgcactgggt tgtccaggga gacctagtgc tgtttctccc acatattcac atacgtgtct     1500

gtgtgtatat atattttttc aatttaaagg ttagtatgga atcagctgct acaagaatgc     1560

aaaaaatctt ccaaagacaa gaaaagagga aaaaaagccg ttttcatgag ctgagtgatg     1620

tagcgtaaca aacaaaatca tggagctgag gaggtgcctt gtaaacatga aggggcagat     1680

aaaggaagga gatactcatg ttgataaaga gagccctggt cctagacata gttcagccac     1740

aaagtagttg tccctttgtg gacaagtttc ccaaattccc tggacctctg cttccccatc     1800

tgttaaatga gagaatagag tatggttgat tcccagcatt cagtggtcct gtcaagcaac     1860

ctaacaggct agttctaatt ccctattggg tagatgaggg gatgacaaag aacagttttt     1920

aagctatata ggaaacattg ttattggtgt tgccctatcg tgatttcagt tgaattcatg     1980

tgaaaataat agccatcctt ggcctggcgc ggtggctcac acctgtaatc ccagcacttt     2040

tggaggccaa ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat     2100

gatgaaaccc cgtctctact aaaaatacaa aaaattagcc gggcatgatg gcaggtgcct     2160

gtaatcccag ctacttggga ggctgaagcg gaagaatcgc ttgaacccag aggtggaggt     2220

tgcagtgagc cgagatcgtg ccattgcact gtaacctggg tgactgagca aaactctgtc     2280

tcaaaataat aataacaata taataataat aatagccatc ctttattgta cccttactgg     2340

gttaatcgta ttataccaca ttacctcatt ttaattttta ctgacctgca ctttatacaa     2400

agcaacaagc ctccaggaca ttaaaattca tgcaaagtta tgctcatgtt atattatttt     2460

cttacttaaa gaaggattta ttagtggctg ggcatggtgg cgtgcacctg taatcccagg     2520

tactcaggag gctgagacgg gagaattgct tgaccccagg cggaggaggt tacagtgagt     2580

cgagatcgta cctgagcgac agagcgagac tccgtctcaa aaaaaaaaaa aaggagggtt     2640

tattaatgag aagtttgtat taatatgtag caaaggcttt tccaatgggt gaataaaaac     2700

acattccatt aagtcaagct gggagcagtg gcatatacct atagtcccag ctgcacagga     2760

ggctgagaca ggaggattgc ttgaagccag gaattggaga tcagcctggg caacacagca     2820

agatcctatc tcttaaaaaa agaaaaaaaa acctattaat aataaaacag tataaacaaa     2880

agctaaatag gtaaaatatt ttttctgaaa taaaattatt ttttgagtct gatggaaatg     2940

tttaagtgca gtaggccagt gccagtgaga aaataaataa catcatacat gtttgtatgt     3000

gtttgcatct tgcttctact gaaagtttca gtgcacccca cttacttaga actcggtgac     3060

atgatgtact cctttatctg ggacacagca caaaagaggt atgcagtggg gctgctctga     3120

catgaaagtg gaagttaagg aatctgggct cttatggggt ccttgtgggc cagcccttca     3180

ggcctatttt actttcattt tacatatagc tctaattggt ttgattatct cgttcccaag     3240

gcagtgggag atccccattt aaggaaagaa aaggggcctg gcacagtggc tcatgcctgt     3300

aatcccagca ctttgggagg ctgaggcaag tgtatcacct gaggtcagga gttcaagacc     3360

agcctggcca acatggcaaa atcccgtctc tactaaaaat attaaaaaat tggctgggcg     3420

tggtggttcg tgcctataat ttcagctact caggaggctg aggcaggaga atcgctgtaa     3480

cctggggggt ggaggttgca gtgagacgag atcatgccac ttcactccag cctggccaac     3540

agagccatac tccgtctcaa ataaataaat aaataaataa agggacttca aacacatgaa     3600

cagcagccag gggaagaatc aaaatcatat tctgtcaagc aaactggaaa agtaccactg     3660

tgtgtaccaa tagcctcccc accacagacc ctgggagcat cgcctcattt atggtgtggt     3720

ccagtcatcc atgtgaagga tgagtttcca ggaaaaggtt attaaatatt cactgtaaca     3780

tactggagga ggtgaggaat tgcataatac aatcttagaa aacttttttt tcccctttct     3840

attttttgag acaggatctc actttggcac tcaggctgga ggacagtggt acaatcaaag     3900

ctcatggcag cctcgacctc cctgggcttg ggcaatcctc ccacaggtgt gcacctccat     3960

agctggctaa tttgtgtatt ttttgtagag atggggtttc accatgttgc ccaggctggt     4020

ctctaacact taggctcaag tgatccacct gcctcgtcct cccaagatgc tgggattaca     4080

ggtgtgtgcc acaggtgttc atcagaaagc tttttctatt atttttacct tcttgagtgg     4140

gtagaacctc agccacatag aaaataaaat gttctggcat gacttattta gctctctgga     4200

attacaaaga aggaatgagg tgtgtaaaag agaacctggg tttttgaatc acaaatttag     4260

aatttaatcg aaactctgcc tcttacttgt ttgtagacac tgacagtggc ctcatgtttt     4320

tttttttttt aatctataaa atggagatat ctaacatgtt gagcctgggc ccacaggcaa     4380

agcacaatcc tgatgtgaga agtactcagt tcatgacaac tgttgttctc acatgcatag     4440

cataatttca tattcacatt ggaggacttc tcccaaaata tggatgacgt tccctactca     4500

accttgaact taatcaaaat actcagttta cttaacttcg tattagattc tgattccctg     4560

gaaccattta tcgtgtgcct taccatgctt atattttact tgatcttttg cataccttct     4620

aaaactattt tagccaattt aaaatttgac agtttgcatt aaattatagg tttacaatat     4680

gctttatcca gctatacctg ccccaaattc tgacagatgc ttttgccacc tctaaaggaa     4740

gacccatgtt catagtgatg gagtttgtgt ggactaacca tgcaaggttg ccaaggaaaa     4800

atcgctttac gcttccaagg tacacactaa gatgaaagta attttagtcc gtgtccagtt     4860

ggattcttgg cacatagtta tcttctgcta gaacaaacta aaacagctac atgccagcaa     4920

gggagaaagg ggaaggaggg gcaaagtttt gaaatttcat gtaaatttat gctgttcaaa     4980

acgacgagtt catgactttg tgtatagagt aagaaatgcc ttttcttttt tgagacagag     5040

tcttgctctg tcacccaggc tggagtgcag tggcacgatc tgggctcact acaacctccg     5100

cctcctgggt tcaagcaatt ctctgcctca gcctcccgag tagctgggat tacaggtgcc     5160

tgccaccaca cccggctaat ttttgtattt ttagtagaga cggggtttca ccatcatggc     5220

caggctggtc ttgaactcct gacctagtaa tccacctgcc tccgcctccc aaagtgctgg     5280

gattacaggc gtgagccact gcacccagcc agaaatgcct tctaatcttt ggtttatctt     5340

aattagccag gacacttgga gtgcatcccg aagtacctga tcagtggccc ctttggaatg     5400

tgtaaaactc agctcactta tatccctgca tccgctacag agacagaatc caagctcata     5460

tgttccatct tctctggctg tatagtttaa ggaatggaag gcaccagaac agatttattg     5520

aaatgtttat tagctgaaga tttatttaga cagttgagga aaacatcagc acccagcagt     5580

aaaattggct ctcaaagatt ttcttctcct gtggaaagtc agacctctga ggccccatcc     5640

aggtagaagt actagtgcaa gaagggcctc tgctgtccac ttgtgtttct gtgatctgtg     5700

ggaacattgt taacgccaca tcttgacctc aaattgttta gctcctggcc agacacggtg     5760

gctcacacct gtaatcccag cactttgaga ggctgaggca ggtggatcac ctgaggttag     5820

gagttcgagg ccagcctggt caacatggta aaaccccgcc tctactaaaa atacaaaaat     5880

tagctggccg tagtggcgca cgcctgttat cccagctact cgggaggctg aggcaggaga     5940

attgcttgaa cctgggtggt ggaggttgca gtgagccgag attacaccac tgcactccag     6000

cctgggtgac aagagggaaa ctccattaaa aaaatgtaat tcccgtgtct gccatcttaa     6060

gtgtaaaggt ggctaaatta tatagaaaaa taagacaata tcatttccca attacattcc     6120

tttcctaccg cactctatga tgctagctga gatttttcca aaagaaaatg gcttaaataa     6180

aaccctaaga gaaagaaaaa ctttaaatcc ctccaaagct caaaagtaat agaaacagat     6240

gagtttggag tcaggatttc tctgtaagat tgcctaggct gtgtactgca catctccagg     6300

tgccactgtt gacagagatt ataactacaa tgtgaagtga atggtgccac tgacagttat     6360

gcaaaccgtc cagagcatag ccacctgatc ctgctgggat tcctcttgcc agtccatcag     6420

cagttcccct tgaaagtttc accaaacatc ccttaaatct gccctctcct gcccgtcccc     6480

agtggaggtc ctcatcattt ttcacctgca tttttgcagg agctttctta tatccacctt     6540

cctccttttc tctcagccca tcatctagct acacagtctc cagggtaagc tttcagaaag     6600

gcaatctctt gtctgtaaaa cctaagcagg accaaggcca agtttcttag cctgaaaaat     6660

gtgcttttct gactgaactg ttcaggcact gactctacat ataattatgc ttttctaccc     6720

cctcacactc aacactttga ctccagcaat cccaaatccc cagatcccta agtgtgctgt     6780

gctattttca cgtggctctc agacttggcc agtgctgttt ccattttggt ctttattccc     6840

cacatctctg cctggggggt agattctacc ctgaaaaatg ttcttggcac agccttgcaa     6900

actcctcctc cactcagcct ctgcctggat gcccttgatt gttccatgtc ctcagcatac     6960

catgtttgtc tttcccagca ctgacctacc atgtgtcacc cctgcttggc tgtaccttcc     7020

atgaggctag gactatgtgt ctcctttgtt gactgctgtt gccctagcat cttgcacagt     7080

tccttgcaca caattagagc tctataaatg tcaaataaat gtgttataat tatatgttta     7140

agatagttgt tcaaataaac tctaaataac cccaac                               7176


<210>  2
<211>  454
<212>  DNA
<213>  Homo sapiens

<400>  2
caactctgcc ggccgcggga cccgggtgag ggtctgggcc tgggctgggc tgggtgacgc       60

caggaggccg gctactgcgc ggcgcccgag agtccacatg ctgctccggg tctgccgccc      120

gctccgccct ccagcgctgg gtgctgcggc gacccctggt ggccactggc cgcaggcact      180

cttctgtggg ggagcagcta gaggttagac ctcaggaaga acttcccagc ttagcactat      240

tcgtgcattt aacaaaaatg gagagcctgc tttgtgcaaa gcacggagtg caaccaggac      300

ccctgaccca agggagactg cagcctggtg gcccgccgct tctaaaattc taaacaggag      360

gaacttggga gctgctgtct tgctgggaag tgggtgcatg cacaaattga ggctgcttgg      420

ccgccggtat gggtttacag cagttgggta tgtg                                  454


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  3
gctcccaagt tcctcctgtt                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
cggagcagca tgtggactct                                                   20


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
ggagcagcat gtggactct                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
gtctaacctc tagctgctcc c                                                 21


