                         SEQUENCE LISTING

<110>  Yale University
       Vortmeyer, Alexander O
       Li, Jie
 
<120>  Discovery and Usage of Biomarkers for Assessment of the Molecular
        Quality in Biospecimens prior to Their Downstream Applications

<130>  047162-5097-00-WO.601359

<150>  US 61/494,135
<151>  2011-06-07

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  2477
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
1               5                   10                  15      


Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
            20                  25                  30          


Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
        35                  40                  45              


Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
    50                  55                  60                  


Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                85                  90                  95      


Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
            100                 105                 110         


Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
        115                 120                 125             


Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
    130                 135                 140                 


Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
145                 150                 155                 160 


Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                165                 170                 175     


Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
            180                 185                 190         


Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
        195                 200                 205             


Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
    210                 215                 220                 


Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
225                 230                 235                 240 


Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                245                 250                 255     


Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
            260                 265                 270         


Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
        275                 280                 285             


Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
    290                 295                 300                 


Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
305                 310                 315                 320 


Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                325                 330                 335     


Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
            340                 345                 350         


Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
        355                 360                 365             


Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
    370                 375                 380                 


Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                405                 410                 415     


Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
            420                 425                 430         


Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
        435                 440                 445             


Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
    450                 455                 460                 


Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
465                 470                 475                 480 


Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                485                 490                 495     


Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
            500                 505                 510         


Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
        515                 520                 525             


Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
    530                 535                 540                 


Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
545                 550                 555                 560 


Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                565                 570                 575     


Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
            580                 585                 590         


Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
        595                 600                 605             


Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
    610                 615                 620                 


Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
625                 630                 635                 640 


Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                645                 650                 655     


Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
            660                 665                 670         


Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
        675                 680                 685             


Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
    690                 695                 700                 


Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
705                 710                 715                 720 


Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                725                 730                 735     


Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
            740                 745                 750         


Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
        755                 760                 765             


Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
    770                 775                 780                 


Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
785                 790                 795                 800 


Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                805                 810                 815     


Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
            820                 825                 830         


Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
        835                 840                 845             


Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
    850                 855                 860                 


Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
865                 870                 875                 880 


Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                885                 890                 895     


Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
            900                 905                 910         


Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
        915                 920                 925             


Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
    930                 935                 940                 


Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
945                 950                 955                 960 


Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                965                 970                 975     


Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
            980                 985                 990         


Ile Leu Thr Leu Leu Asn Ser Thr  Asn Lys Asp Trp Trp  Lys Val Glu 
        995                 1000                 1005             


Val Asn  Asp Arg Gln Gly Phe  Val Pro Ala Ala Tyr  Val Lys Lys 
    1010                 1015                 1020             


Leu Asp  Pro Ala Gln Ser Ala  Ser Arg Glu Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gln Gly  Ser Ile Ala Leu Arg  Gln Glu Gln Ile Asp  Asn Gln Thr 
    1040                 1045                 1050             


Arg Ile  Thr Lys Glu Ala Gly  Ser Val Ser Leu Arg  Met Lys Gln 
    1055                 1060                 1065             


Val Glu  Glu Leu Tyr His Ser  Leu Leu Glu Leu Gly  Glu Lys Arg 
    1070                 1075                 1080             


Lys Gly  Met Leu Glu Lys Ser  Cys Lys Lys Phe Met  Leu Phe Arg 
    1085                 1090                 1095             


Glu Ala  Asn Glu Leu Gln Gln  Trp Ile Asn Glu Lys  Glu Ala Ala 
    1100                 1105                 1110             


Leu Thr  Ser Glu Glu Val Gly  Ala Asp Leu Glu Gln  Val Glu Val 
    1115                 1120                 1125             


Leu Gln  Lys Lys Phe Asp Asp  Phe Gln Lys Asp Leu  Lys Ala Asn 
    1130                 1135                 1140             


Glu Ser  Arg Leu Lys Asp Ile  Asn Lys Val Ala Glu  Asp Leu Glu 
    1145                 1150                 1155             


Ser Glu  Gly Leu Met Ala Glu  Glu Val Gln Ala Val  Gln Gln Gln 
    1160                 1165                 1170             


Glu Val  Tyr Gly Met Met Pro  Arg Asp Glu Thr Asp  Ser Lys Thr 
    1175                 1180                 1185             


Ala Ser  Pro Trp Lys Ser Ala  Arg Leu Met Val His  Thr Val Ala 
    1190                 1195                 1200             


Thr Phe  Asn Ser Ile Lys Glu  Leu Asn Glu Arg Trp  Arg Ser Leu 
    1205                 1210                 1215             


Gln Gln  Leu Ala Glu Glu Arg  Ser Gln Leu Leu Gly  Ser Ala His 
    1220                 1225                 1230             


Glu Val  Gln Arg Phe His Arg  Asp Ala Asp Glu Thr  Lys Glu Trp 
    1235                 1240                 1245             


Ile Glu  Glu Lys Asn Gln Ala  Leu Asn Thr Asp Asn  Tyr Gly His 
    1250                 1255                 1260             


Asp Leu  Ala Ser Val Gln Ala  Leu Gln Arg Lys His  Glu Gly Phe 
    1265                 1270                 1275             


Glu Arg  Asp Leu Ala Ala Leu  Gly Asp Lys Val Asn  Ser Leu Gly 
    1280                 1285                 1290             


Glu Thr  Ala Glu Arg Leu Ile  Gln Ser His Pro Glu  Ser Ala Glu 
    1295                 1300                 1305             


Asp Leu  Gln Glu Lys Cys Thr  Glu Leu Asn Gln Ala  Trp Ser Ser 
    1310                 1315                 1320             


Leu Gly  Lys Arg Ala Asp Gln  Arg Lys Ala Lys Leu  Gly Asp Ser 
    1325                 1330                 1335             


His Asp  Leu Gln Arg Phe Leu  Ser Asp Phe Arg Asp  Leu Met Ser 
    1340                 1345                 1350             


Trp Ile  Asn Gly Ile Arg Gly  Leu Val Ser Ser Asp  Glu Leu Ala 
    1355                 1360                 1365             


Lys Asp  Val Thr Gly Ala Glu  Ala Leu Leu Glu Arg  His Gln Glu 
    1370                 1375                 1380             


His Arg  Thr Glu Ile Asp Ala  Arg Ala Gly Thr Phe  Gln Ala Phe 
    1385                 1390                 1395             


Glu Gln  Phe Gly Gln Gln Leu  Leu Ala His Gly His  Tyr Ala Ser 
    1400                 1405                 1410             


Pro Glu  Ile Lys Gln Lys Leu  Asp Ile Leu Asp Gln  Glu Arg Ala 
    1415                 1420                 1425             


Asp Leu  Glu Lys Ala Trp Val  Gln Arg Arg Met Met  Leu Asp Gln 
    1430                 1435                 1440             


Cys Leu  Glu Leu Gln Leu Phe  His Arg Asp Cys Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Trp  Met Ala Ala Arg Glu  Ala Phe Leu Asn Thr  Glu Asp Lys 
    1460                 1465                 1470             


Gly Asp  Ser Leu Asp Ser Val  Glu Ala Leu Ile Lys  Lys His Glu 
    1475                 1480                 1485             


Asp Phe  Asp Lys Ala Ile Asn  Val Gln Glu Glu Lys  Ile Ala Ala 
    1490                 1495                 1500             


Leu Gln  Ala Phe Ala Asp Gln  Leu Ile Ala Ala Gly  His Tyr Ala 
    1505                 1510                 1515             


Lys Gly  Asp Ile Ser Ser Arg  Arg Asn Glu Val Leu  Asp Arg Trp 
    1520                 1525                 1530             


Arg Arg  Leu Lys Ala Gln Met  Ile Glu Lys Arg Ser  Lys Leu Gly 
    1535                 1540                 1545             


Glu Ser  Gln Thr Leu Gln Gln  Phe Ser Arg Asp Val  Asp Glu Ile 
    1550                 1555                 1560             


Glu Ala  Trp Ile Ser Glu Lys  Leu Gln Thr Ala Ser  Asp Glu Ser 
    1565                 1570                 1575             


Tyr Lys  Asp Pro Thr Asn Ile  Gln Leu Ser Lys Leu  Leu Ser Lys 
    1580                 1585                 1590             


His Gln  Lys His Gln Ala Phe  Glu Ala Glu Leu His  Ala Asn Ala 
    1595                 1600                 1605             


Asp Arg  Ile Arg Gly Val Ile  Asp Met Gly Asn Ser  Leu Ile Glu 
    1610                 1615                 1620             


Arg Gly  Ala Cys Ala Gly Ser  Glu Asp Ala Val Lys  Ala Arg Leu 
    1625                 1630                 1635             


Ala Ala  Leu Ala Asp Gln Trp  Gln Phe Leu Val Gln  Lys Ser Ala 
    1640                 1645                 1650             


Glu Lys  Ser Gln Lys Leu Lys  Glu Ala Asn Lys Gln  Gln Asn Phe 
    1655                 1660                 1665             


Asn Thr  Gly Ile Lys Asp Phe  Asp Phe Trp Leu Ser  Glu Val Glu 
    1670                 1675                 1680             


Ala Leu  Leu Ala Ser Glu Asp  Tyr Gly Lys Asp Leu  Ala Ser Val 
    1685                 1690                 1695             


Asn Asn  Leu Leu Lys Lys His  Gln Leu Leu Glu Ala  Asp Ile Ser 
    1700                 1705                 1710             


Ala His  Glu Asp Arg Leu Lys  Asp Leu Asn Ser Gln  Ala Asp Ser 
    1715                 1720                 1725             


Leu Met  Thr Ser Ser Ala Phe  Asp Thr Ser Gln Val  Lys Asp Lys 
    1730                 1735                 1740             


Arg Asp  Thr Ile Asn Gly Arg  Phe Gln Lys Ile Lys  Ser Met Ala 
    1745                 1750                 1755             


Ala Ser  Arg Arg Ala Lys Leu  Asn Glu Ser His Arg  Leu His Gln 
    1760                 1765                 1770             


Phe Phe  Arg Asp Met Asp Asp  Glu Glu Ser Trp Ile  Lys Glu Lys 
    1775                 1780                 1785             


Lys Leu  Leu Val Gly Ser Glu  Asp Tyr Gly Arg Asp  Leu Thr Gly 
    1790                 1795                 1800             


Val Gln  Asn Leu Arg Lys Lys  His Lys Arg Leu Glu  Ala Glu Leu 
    1805                 1810                 1815             


Ala Ala  His Glu Pro Ala Ile  Gln Gly Val Leu Asp  Thr Gly Lys 
    1820                 1825                 1830             


Lys Leu  Ser Asp Asp Asn Thr  Ile Gly Lys Glu Glu  Ile Gln Gln 
    1835                 1840                 1845             


Arg Leu  Ala Gln Phe Val Glu  His Trp Lys Glu Leu  Lys Gln Leu 
    1850                 1855                 1860             


Ala Ala  Ala Arg Gly Gln Arg  Leu Glu Glu Ser Leu  Glu Tyr Gln 
    1865                 1870                 1875             


Gln Phe  Val Ala Asn Val Glu  Glu Glu Glu Ala Trp  Ile Asn Glu 
    1880                 1885                 1890             


Lys Met  Thr Leu Val Ala Ser  Glu Asp Tyr Gly Asp  Thr Leu Ala 
    1895                 1900                 1905             


Ala Ile  Gln Gly Leu Leu Lys  Lys His Glu Ala Phe  Glu Thr Asp 
    1910                 1915                 1920             


Phe Thr  Val His Lys Asp Arg  Val Asn Asp Val Cys  Thr Asn Gly 
    1925                 1930                 1935             


Gln Asp  Leu Ile Lys Lys Asn  Asn His His Glu Glu  Asn Ile Ser 
    1940                 1945                 1950             


Ser Lys  Met Lys Gly Leu Asn  Gly Lys Val Ser Asp  Leu Glu Lys 
    1955                 1960                 1965             


Ala Ala  Ala Gln Arg Lys Ala  Lys Leu Asp Glu Asn  Ser Ala Phe 
    1970                 1975                 1980             


Leu Gln  Phe Asn Trp Lys Ala  Asp Val Val Glu Ser  Trp Ile Gly 
    1985                 1990                 1995             


Glu Lys  Glu Asn Ser Leu Lys  Thr Asp Asp Tyr Gly  Arg Asp Leu 
    2000                 2005                 2010             


Ser Ser  Val Gln Thr Leu Leu  Thr Lys Gln Glu Thr  Phe Asp Ala 
    2015                 2020                 2025             


Gly Leu  Gln Ala Phe Gln Gln  Glu Gly Ile Ala Asn  Ile Thr Ala 
    2030                 2035                 2040             


Leu Lys  Asp Gln Leu Leu Ala  Ala Lys His Val Gln  Ser Lys Ala 
    2045                 2050                 2055             


Ile Glu  Ala Arg His Ala Ser  Leu Met Lys Arg Trp  Ser Gln Leu 
    2060                 2065                 2070             


Leu Ala  Asn Ser Ala Ala Arg  Lys Lys Lys Leu Leu  Glu Ala Gln 
    2075                 2080                 2085             


Ser His  Phe Arg Lys Val Glu  Asp Leu Phe Leu Thr  Phe Ala Lys 
    2090                 2095                 2100             


Lys Ala  Ser Ala Phe Asn Ser  Trp Phe Glu Asn Ala  Glu Glu Asp 
    2105                 2110                 2115             


Leu Thr  Asp Pro Val Arg Cys  Asn Ser Leu Glu Glu  Ile Lys Ala 
    2120                 2125                 2130             


Leu Arg  Glu Ala His Asp Ala  Phe Arg Ser Ser Leu  Ser Ser Ala 
    2135                 2140                 2145             


Gln Ala  Asp Phe Asn Gln Leu  Ala Glu Leu Asp Arg  Gln Ile Lys 
    2150                 2155                 2160             


Ser Phe  Arg Val Ala Ser Asn  Pro Tyr Thr Trp Phe  Thr Met Glu 
    2165                 2170                 2175             


Ala Leu  Glu Glu Thr Trp Arg  Asn Leu Gln Lys Ile  Ile Lys Glu 
    2180                 2185                 2190             


Arg Glu  Leu Glu Leu Gln Lys  Glu Gln Arg Arg Gln  Glu Glu Asn 
    2195                 2200                 2205             


Asp Lys  Leu Arg Gln Glu Phe  Ala Gln His Ala Asn  Ala Phe His 
    2210                 2215                 2220             


Gln Trp  Ile Gln Glu Thr Arg  Thr Tyr Leu Leu Asp  Gly Ser Cys 
    2225                 2230                 2235             


Met Val  Glu Glu Ser Gly Thr  Leu Glu Ser Gln Leu  Glu Ala Thr 
    2240                 2245                 2250             


Lys Arg  Lys His Gln Glu Ile  Arg Ala Met Arg Ser  Gln Leu Lys 
    2255                 2260                 2265             


Lys Ile  Glu Asp Leu Gly Ala  Ala Met Glu Glu Ala  Leu Ile Leu 
    2270                 2275                 2280             


Asp Asn  Lys Tyr Thr Glu His  Ser Thr Val Gly Leu  Ala Gln Gln 
    2285                 2290                 2295             


Trp Asp  Gln Leu Asp Gln Leu  Gly Met Arg Met Gln  His Asn Leu 
    2300                 2305                 2310             


Glu Gln  Gln Ile Gln Ala Arg  Asn Thr Thr Gly Val  Thr Glu Glu 
    2315                 2320                 2325             


Ala Leu  Lys Glu Phe Ser Met  Met Phe Lys His Phe  Asp Lys Asp 
    2330                 2335                 2340             


Lys Ser  Gly Arg Leu Asn His  Gln Glu Phe Lys Ser  Cys Leu Arg 
    2345                 2350                 2355             


Ser Leu  Gly Tyr Asp Leu Pro  Met Val Glu Glu Gly  Glu Pro Asp 
    2360                 2365                 2370             


Pro Glu  Phe Glu Ala Ile Leu  Asp Thr Val Asp Pro  Asn Arg Asp 
    2375                 2380                 2385             


Gly His  Val Ser Leu Gln Glu  Tyr Met Ala Phe Met  Ile Ser Arg 
    2390                 2395                 2400             


Glu Thr  Glu Asn Val Lys Ser  Ser Glu Glu Ile Glu  Ser Ala Phe 
    2405                 2410                 2415             


Arg Ala  Leu Ser Ser Glu Gly  Lys Pro Tyr Val Thr  Lys Glu Glu 
    2420                 2425                 2430             


Leu Tyr  Gln Asn Leu Thr Arg  Glu Gln Ala Asp Tyr  Cys Val Ser 
    2435                 2440                 2445             


His Met  Lys Pro Tyr Val Asp  Gly Lys Gly Arg Glu  Leu Pro Thr 
    2450                 2455                 2460             


Ala Phe  Asp Tyr Val Glu Phe  Thr Arg Ser Leu Phe  Val Asn 
    2465                 2470                 2475         


<210>  2
<211>  2452
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
1               5                   10                  15      


Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
            20                  25                  30          


Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
        35                  40                  45              


Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
    50                  55                  60                  


Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                85                  90                  95      


Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
            100                 105                 110         


Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
        115                 120                 125             


Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
    130                 135                 140                 


Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
145                 150                 155                 160 


Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                165                 170                 175     


Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
            180                 185                 190         


Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
        195                 200                 205             


Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
    210                 215                 220                 


Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
225                 230                 235                 240 


Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                245                 250                 255     


Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
            260                 265                 270         


Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
        275                 280                 285             


Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
    290                 295                 300                 


Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
305                 310                 315                 320 


Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                325                 330                 335     


Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
            340                 345                 350         


Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
        355                 360                 365             


Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
    370                 375                 380                 


Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                405                 410                 415     


Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
            420                 425                 430         


Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
        435                 440                 445             


Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
    450                 455                 460                 


Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
465                 470                 475                 480 


Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                485                 490                 495     


Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
            500                 505                 510         


Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
        515                 520                 525             


Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
    530                 535                 540                 


Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
545                 550                 555                 560 


Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                565                 570                 575     


Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
            580                 585                 590         


Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
        595                 600                 605             


Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
    610                 615                 620                 


Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
625                 630                 635                 640 


Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                645                 650                 655     


Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
            660                 665                 670         


Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
        675                 680                 685             


Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
    690                 695                 700                 


Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
705                 710                 715                 720 


Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                725                 730                 735     


Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
            740                 745                 750         


Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
        755                 760                 765             


Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
    770                 775                 780                 


Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
785                 790                 795                 800 


Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                805                 810                 815     


Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
            820                 825                 830         


Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
        835                 840                 845             


Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
    850                 855                 860                 


Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
865                 870                 875                 880 


Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                885                 890                 895     


Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
            900                 905                 910         


Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
        915                 920                 925             


Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
    930                 935                 940                 


Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
945                 950                 955                 960 


Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                965                 970                 975     


Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
            980                 985                 990         


Ile Leu Thr Leu Leu Asn Ser Thr  Asn Lys Asp Trp Trp  Lys Val Glu 
        995                 1000                 1005             


Val Asn  Asp Arg Gln Gly Phe  Val Pro Ala Ala Tyr  Val Lys Lys 
    1010                 1015                 1020             


Leu Asp  Pro Ala Gln Ser Ala  Ser Arg Glu Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gln Gly  Ser Ile Ala Leu Arg  Gln Glu Gln Ile Asp  Asn Gln Tyr 
    1040                 1045                 1050             


His Ser  Leu Leu Glu Leu Gly  Glu Lys Arg Lys Gly  Met Leu Glu 
    1055                 1060                 1065             


Lys Ser  Cys Lys Lys Phe Met  Leu Phe Arg Glu Ala  Asn Glu Leu 
    1070                 1075                 1080             


Gln Gln  Trp Ile Asn Glu Lys  Glu Ala Ala Leu Thr  Ser Glu Glu 
    1085                 1090                 1095             


Val Gly  Ala Asp Leu Glu Gln  Val Glu Val Leu Gln  Lys Lys Phe 
    1100                 1105                 1110             


Asp Asp  Phe Gln Lys Asp Leu  Lys Ala Asn Glu Ser  Arg Leu Lys 
    1115                 1120                 1125             


Asp Ile  Asn Lys Val Ala Glu  Asp Leu Glu Ser Glu  Gly Leu Met 
    1130                 1135                 1140             


Ala Glu  Glu Val Gln Ala Val  Gln Gln Gln Glu Val  Tyr Gly Met 
    1145                 1150                 1155             


Met Pro  Arg Asp Glu Thr Asp  Ser Lys Thr Ala Ser  Pro Trp Lys 
    1160                 1165                 1170             


Ser Ala  Arg Leu Met Val His  Thr Val Ala Thr Phe  Asn Ser Ile 
    1175                 1180                 1185             


Lys Glu  Leu Asn Glu Arg Trp  Arg Ser Leu Gln Gln  Leu Ala Glu 
    1190                 1195                 1200             


Glu Arg  Ser Gln Leu Leu Gly  Ser Ala His Glu Val  Gln Arg Phe 
    1205                 1210                 1215             


His Arg  Asp Ala Asp Glu Thr  Lys Glu Trp Ile Glu  Glu Lys Asn 
    1220                 1225                 1230             


Gln Ala  Leu Asn Thr Asp Asn  Tyr Gly His Asp Leu  Ala Ser Val 
    1235                 1240                 1245             


Gln Ala  Leu Gln Arg Lys His  Glu Gly Phe Glu Arg  Asp Leu Ala 
    1250                 1255                 1260             


Ala Leu  Gly Asp Lys Val Asn  Ser Leu Gly Glu Thr  Ala Glu Arg 
    1265                 1270                 1275             


Leu Ile  Gln Ser His Pro Glu  Ser Ala Glu Asp Leu  Gln Glu Lys 
    1280                 1285                 1290             


Cys Thr  Glu Leu Asn Gln Ala  Trp Ser Ser Leu Gly  Lys Arg Ala 
    1295                 1300                 1305             


Asp Gln  Arg Lys Ala Lys Leu  Gly Asp Ser His Asp  Leu Gln Arg 
    1310                 1315                 1320             


Phe Leu  Ser Asp Phe Arg Asp  Leu Met Ser Trp Ile  Asn Gly Ile 
    1325                 1330                 1335             


Arg Gly  Leu Val Ser Ser Asp  Glu Leu Ala Lys Asp  Val Thr Gly 
    1340                 1345                 1350             


Ala Glu  Ala Leu Leu Glu Arg  His Gln Glu His Arg  Thr Glu Ile 
    1355                 1360                 1365             


Asp Ala  Arg Ala Gly Thr Phe  Gln Ala Phe Glu Gln  Phe Gly Gln 
    1370                 1375                 1380             


Gln Leu  Leu Ala His Gly His  Tyr Ala Ser Pro Glu  Ile Lys Gln 
    1385                 1390                 1395             


Lys Leu  Asp Ile Leu Asp Gln  Glu Arg Ala Asp Leu  Glu Lys Ala 
    1400                 1405                 1410             


Trp Val  Gln Arg Arg Met Met  Leu Asp Gln Cys Leu  Glu Leu Gln 
    1415                 1420                 1425             


Leu Phe  His Arg Asp Cys Glu  Gln Ala Glu Asn Trp  Met Ala Ala 
    1430                 1435                 1440             


Arg Glu  Ala Phe Leu Asn Thr  Glu Asp Lys Gly Asp  Ser Leu Asp 
    1445                 1450                 1455             


Ser Val  Glu Ala Leu Ile Lys  Lys His Glu Asp Phe  Asp Lys Ala 
    1460                 1465                 1470             


Ile Asn  Val Gln Glu Glu Lys  Ile Ala Ala Leu Gln  Ala Phe Ala 
    1475                 1480                 1485             


Asp Gln  Leu Ile Ala Ala Gly  His Tyr Ala Lys Gly  Asp Ile Ser 
    1490                 1495                 1500             


Ser Arg  Arg Asn Glu Val Leu  Asp Arg Trp Arg Arg  Leu Lys Ala 
    1505                 1510                 1515             


Gln Met  Ile Glu Lys Arg Ser  Lys Leu Gly Glu Ser  Gln Thr Leu 
    1520                 1525                 1530             


Gln Gln  Phe Ser Arg Asp Val  Asp Glu Ile Glu Ala  Trp Ile Ser 
    1535                 1540                 1545             


Glu Lys  Leu Gln Thr Ala Ser  Asp Glu Ser Tyr Lys  Asp Pro Thr 
    1550                 1555                 1560             


Asn Ile  Gln Ser Lys His Gln  Lys His Gln Ala Phe  Glu Ala Glu 
    1565                 1570                 1575             


Leu His  Ala Asn Ala Asp Arg  Ile Arg Gly Val Ile  Asp Met Gly 
    1580                 1585                 1590             


Asn Ser  Leu Ile Glu Arg Gly  Ala Cys Ala Gly Ser  Glu Asp Ala 
    1595                 1600                 1605             


Val Lys  Ala Arg Leu Ala Ala  Leu Ala Asp Gln Trp  Gln Phe Leu 
    1610                 1615                 1620             


Val Gln  Lys Ser Ala Glu Lys  Ser Gln Lys Leu Lys  Glu Ala Asn 
    1625                 1630                 1635             


Lys Gln  Gln Asn Phe Asn Thr  Gly Ile Lys Asp Phe  Asp Phe Trp 
    1640                 1645                 1650             


Leu Ser  Glu Val Glu Ala Leu  Leu Ala Ser Glu Asp  Tyr Gly Lys 
    1655                 1660                 1665             


Asp Leu  Ala Ser Val Asn Asn  Leu Leu Lys Lys His  Gln Leu Leu 
    1670                 1675                 1680             


Glu Ala  Asp Ile Ser Ala His  Glu Asp Arg Leu Lys  Asp Leu Asn 
    1685                 1690                 1695             


Ser Gln  Ala Asp Ser Leu Met  Thr Ser Ser Ala Phe  Asp Thr Ser 
    1700                 1705                 1710             


Gln Val  Lys Asp Lys Arg Asp  Thr Ile Asn Gly Arg  Phe Gln Lys 
    1715                 1720                 1725             


Ile Lys  Ser Met Ala Ala Ser  Arg Arg Ala Lys Leu  Asn Glu Ser 
    1730                 1735                 1740             


His Arg  Leu His Gln Phe Phe  Arg Asp Met Asp Asp  Glu Glu Ser 
    1745                 1750                 1755             


Trp Ile  Lys Glu Lys Lys Leu  Leu Val Gly Ser Glu  Asp Tyr Gly 
    1760                 1765                 1770             


Arg Asp  Leu Thr Gly Val Gln  Asn Leu Arg Lys Lys  His Lys Arg 
    1775                 1780                 1785             


Leu Glu  Ala Glu Leu Ala Ala  His Glu Pro Ala Ile  Gln Gly Val 
    1790                 1795                 1800             


Leu Asp  Thr Gly Lys Lys Leu  Ser Asp Asp Asn Thr  Ile Gly Lys 
    1805                 1810                 1815             


Glu Glu  Ile Gln Gln Arg Leu  Ala Gln Phe Val Glu  His Trp Lys 
    1820                 1825                 1830             


Glu Leu  Lys Gln Leu Ala Ala  Ala Arg Gly Gln Arg  Leu Glu Glu 
    1835                 1840                 1845             


Ser Leu  Glu Tyr Gln Gln Phe  Val Ala Asn Val Glu  Glu Glu Glu 
    1850                 1855                 1860             


Ala Trp  Ile Asn Glu Lys Met  Thr Leu Val Ala Ser  Glu Asp Tyr 
    1865                 1870                 1875             


Gly Asp  Thr Leu Ala Ala Ile  Gln Gly Leu Leu Lys  Lys His Glu 
    1880                 1885                 1890             


Ala Phe  Glu Thr Asp Phe Thr  Val His Lys Asp Arg  Val Asn Asp 
    1895                 1900                 1905             


Val Cys  Thr Asn Gly Gln Asp  Leu Ile Lys Lys Asn  Asn His His 
    1910                 1915                 1920             


Glu Glu  Asn Ile Ser Ser Lys  Met Lys Gly Leu Asn  Gly Lys Val 
    1925                 1930                 1935             


Ser Asp  Leu Glu Lys Ala Ala  Ala Gln Arg Lys Ala  Lys Leu Asp 
    1940                 1945                 1950             


Glu Asn  Ser Ala Phe Leu Gln  Phe Asn Trp Lys Ala  Asp Val Val 
    1955                 1960                 1965             


Glu Ser  Trp Ile Gly Glu Lys  Glu Asn Ser Leu Lys  Thr Asp Asp 
    1970                 1975                 1980             


Tyr Gly  Arg Asp Leu Ser Ser  Val Gln Thr Leu Leu  Thr Lys Gln 
    1985                 1990                 1995             


Glu Thr  Phe Asp Ala Gly Leu  Gln Ala Phe Gln Gln  Glu Gly Ile 
    2000                 2005                 2010             


Ala Asn  Ile Thr Ala Leu Lys  Asp Gln Leu Leu Ala  Ala Lys His 
    2015                 2020                 2025             


Val Gln  Ser Lys Ala Ile Glu  Ala Arg His Ala Ser  Leu Met Lys 
    2030                 2035                 2040             


Arg Trp  Ser Gln Leu Leu Ala  Asn Ser Ala Ala Arg  Lys Lys Lys 
    2045                 2050                 2055             


Leu Leu  Glu Ala Gln Ser His  Phe Arg Lys Val Glu  Asp Leu Phe 
    2060                 2065                 2070             


Leu Thr  Phe Ala Lys Lys Ala  Ser Ala Phe Asn Ser  Trp Phe Glu 
    2075                 2080                 2085             


Asn Ala  Glu Glu Asp Leu Thr  Asp Pro Val Arg Cys  Asn Ser Leu 
    2090                 2095                 2100             


Glu Glu  Ile Lys Ala Leu Arg  Glu Ala His Asp Ala  Phe Arg Ser 
    2105                 2110                 2115             


Ser Leu  Ser Ser Ala Gln Ala  Asp Phe Asn Gln Leu  Ala Glu Leu 
    2120                 2125                 2130             


Asp Arg  Gln Ile Lys Ser Phe  Arg Val Ala Ser Asn  Pro Tyr Thr 
    2135                 2140                 2145             


Trp Phe  Thr Met Glu Ala Leu  Glu Glu Thr Trp Arg  Asn Leu Gln 
    2150                 2155                 2160             


Lys Ile  Ile Lys Glu Arg Glu  Leu Glu Leu Gln Lys  Glu Gln Arg 
    2165                 2170                 2175             


Arg Gln  Glu Glu Asn Asp Lys  Leu Arg Gln Glu Phe  Ala Gln His 
    2180                 2185                 2190             


Ala Asn  Ala Phe His Gln Trp  Ile Gln Glu Thr Arg  Thr Tyr Leu 
    2195                 2200                 2205             


Leu Asp  Gly Ser Cys Met Val  Glu Glu Ser Gly Thr  Leu Glu Ser 
    2210                 2215                 2220             


Gln Leu  Glu Ala Thr Lys Arg  Lys His Gln Glu Ile  Arg Ala Met 
    2225                 2230                 2235             


Arg Ser  Gln Leu Lys Lys Ile  Glu Asp Leu Gly Ala  Ala Met Glu 
    2240                 2245                 2250             


Glu Ala  Leu Ile Leu Asp Asn  Lys Tyr Thr Glu His  Ser Thr Val 
    2255                 2260                 2265             


Gly Leu  Ala Gln Gln Trp Asp  Gln Leu Asp Gln Leu  Gly Met Arg 
    2270                 2275                 2280             


Met Gln  His Asn Leu Glu Gln  Gln Ile Gln Ala Arg  Asn Thr Thr 
    2285                 2290                 2295             


Gly Val  Thr Glu Glu Ala Leu  Lys Glu Phe Ser Met  Met Phe Lys 
    2300                 2305                 2310             


His Phe  Asp Lys Asp Lys Ser  Gly Arg Leu Asn His  Gln Glu Phe 
    2315                 2320                 2325             


Lys Ser  Cys Leu Arg Ser Leu  Gly Tyr Asp Leu Pro  Met Val Glu 
    2330                 2335                 2340             


Glu Gly  Glu Pro Asp Pro Glu  Phe Glu Ala Ile Leu  Asp Thr Val 
    2345                 2350                 2355             


Asp Pro  Asn Arg Asp Gly His  Val Ser Leu Gln Glu  Tyr Met Ala 
    2360                 2365                 2370             


Phe Met  Ile Ser Arg Glu Thr  Glu Asn Val Lys Ser  Ser Glu Glu 
    2375                 2380                 2385             


Ile Glu  Ser Ala Phe Arg Ala  Leu Ser Ser Glu Gly  Lys Pro Tyr 
    2390                 2395                 2400             


Val Thr  Lys Glu Glu Leu Tyr  Gln Asn Leu Thr Arg  Glu Gln Ala 
    2405                 2410                 2415             


Asp Tyr  Cys Val Ser His Met  Lys Pro Tyr Val Asp  Gly Lys Gly 
    2420                 2425                 2430             


Arg Glu  Leu Pro Thr Ala Phe  Asp Tyr Val Glu Phe  Thr Arg Ser 
    2435                 2440                 2445             


Leu Phe  Val Asn 
    2450         


<210>  3
<211>  2472
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
1               5                   10                  15      


Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
            20                  25                  30          


Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
        35                  40                  45              


Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
    50                  55                  60                  


Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                85                  90                  95      


Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
            100                 105                 110         


Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
        115                 120                 125             


Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
    130                 135                 140                 


Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
145                 150                 155                 160 


Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                165                 170                 175     


Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
            180                 185                 190         


Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
        195                 200                 205             


Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
    210                 215                 220                 


Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
225                 230                 235                 240 


Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                245                 250                 255     


Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
            260                 265                 270         


Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
        275                 280                 285             


Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
    290                 295                 300                 


Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
305                 310                 315                 320 


Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                325                 330                 335     


Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
            340                 345                 350         


Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
        355                 360                 365             


Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
    370                 375                 380                 


Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                405                 410                 415     


Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
            420                 425                 430         


Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
        435                 440                 445             


Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
    450                 455                 460                 


Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
465                 470                 475                 480 


Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                485                 490                 495     


Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
            500                 505                 510         


Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
        515                 520                 525             


Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
    530                 535                 540                 


Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
545                 550                 555                 560 


Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                565                 570                 575     


Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
            580                 585                 590         


Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
        595                 600                 605             


Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
    610                 615                 620                 


Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
625                 630                 635                 640 


Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                645                 650                 655     


Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
            660                 665                 670         


Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
        675                 680                 685             


Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
    690                 695                 700                 


Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
705                 710                 715                 720 


Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                725                 730                 735     


Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
            740                 745                 750         


Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
        755                 760                 765             


Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
    770                 775                 780                 


Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
785                 790                 795                 800 


Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                805                 810                 815     


Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
            820                 825                 830         


Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
        835                 840                 845             


Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
    850                 855                 860                 


Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
865                 870                 875                 880 


Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                885                 890                 895     


Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
            900                 905                 910         


Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
        915                 920                 925             


Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
    930                 935                 940                 


Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
945                 950                 955                 960 


Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                965                 970                 975     


Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
            980                 985                 990         


Ile Leu Thr Leu Leu Asn Ser Thr  Asn Lys Asp Trp Trp  Lys Val Glu 
        995                 1000                 1005             


Val Asn  Asp Arg Gln Gly Phe  Val Pro Ala Ala Tyr  Val Lys Lys 
    1010                 1015                 1020             


Leu Asp  Pro Ala Gln Ser Ala  Ser Arg Glu Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gln Gly  Ser Ile Ala Leu Arg  Gln Glu Gln Ile Asp  Asn Gln Thr 
    1040                 1045                 1050             


Arg Ile  Thr Lys Glu Ala Gly  Ser Val Ser Leu Arg  Met Lys Gln 
    1055                 1060                 1065             


Val Glu  Glu Leu Tyr His Ser  Leu Leu Glu Leu Gly  Glu Lys Arg 
    1070                 1075                 1080             


Lys Gly  Met Leu Glu Lys Ser  Cys Lys Lys Phe Met  Leu Phe Arg 
    1085                 1090                 1095             


Glu Ala  Asn Glu Leu Gln Gln  Trp Ile Asn Glu Lys  Glu Ala Ala 
    1100                 1105                 1110             


Leu Thr  Ser Glu Glu Val Gly  Ala Asp Leu Glu Gln  Val Glu Val 
    1115                 1120                 1125             


Leu Gln  Lys Lys Phe Asp Asp  Phe Gln Lys Asp Leu  Lys Ala Asn 
    1130                 1135                 1140             


Glu Ser  Arg Leu Lys Asp Ile  Asn Lys Val Ala Glu  Asp Leu Glu 
    1145                 1150                 1155             


Ser Glu  Gly Leu Met Ala Glu  Glu Val Gln Ala Val  Gln Gln Gln 
    1160                 1165                 1170             


Glu Val  Tyr Gly Met Met Pro  Arg Asp Glu Thr Asp  Ser Lys Thr 
    1175                 1180                 1185             


Ala Ser  Pro Trp Lys Ser Ala  Arg Leu Met Val His  Thr Val Ala 
    1190                 1195                 1200             


Thr Phe  Asn Ser Ile Lys Glu  Leu Asn Glu Arg Trp  Arg Ser Leu 
    1205                 1210                 1215             


Gln Gln  Leu Ala Glu Glu Arg  Ser Gln Leu Leu Gly  Ser Ala His 
    1220                 1225                 1230             


Glu Val  Gln Arg Phe His Arg  Asp Ala Asp Glu Thr  Lys Glu Trp 
    1235                 1240                 1245             


Ile Glu  Glu Lys Asn Gln Ala  Leu Asn Thr Asp Asn  Tyr Gly His 
    1250                 1255                 1260             


Asp Leu  Ala Ser Val Gln Ala  Leu Gln Arg Lys His  Glu Gly Phe 
    1265                 1270                 1275             


Glu Arg  Asp Leu Ala Ala Leu  Gly Asp Lys Val Asn  Ser Leu Gly 
    1280                 1285                 1290             


Glu Thr  Ala Glu Arg Leu Ile  Gln Ser His Pro Glu  Ser Ala Glu 
    1295                 1300                 1305             


Asp Leu  Gln Glu Lys Cys Thr  Glu Leu Asn Gln Ala  Trp Ser Ser 
    1310                 1315                 1320             


Leu Gly  Lys Arg Ala Asp Gln  Arg Lys Ala Lys Leu  Gly Asp Ser 
    1325                 1330                 1335             


His Asp  Leu Gln Arg Phe Leu  Ser Asp Phe Arg Asp  Leu Met Ser 
    1340                 1345                 1350             


Trp Ile  Asn Gly Ile Arg Gly  Leu Val Ser Ser Asp  Glu Leu Ala 
    1355                 1360                 1365             


Lys Asp  Val Thr Gly Ala Glu  Ala Leu Leu Glu Arg  His Gln Glu 
    1370                 1375                 1380             


His Arg  Thr Glu Ile Asp Ala  Arg Ala Gly Thr Phe  Gln Ala Phe 
    1385                 1390                 1395             


Glu Gln  Phe Gly Gln Gln Leu  Leu Ala His Gly His  Tyr Ala Ser 
    1400                 1405                 1410             


Pro Glu  Ile Lys Gln Lys Leu  Asp Ile Leu Asp Gln  Glu Arg Ala 
    1415                 1420                 1425             


Asp Leu  Glu Lys Ala Trp Val  Gln Arg Arg Met Met  Leu Asp Gln 
    1430                 1435                 1440             


Cys Leu  Glu Leu Gln Leu Phe  His Arg Asp Cys Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Trp  Met Ala Ala Arg Glu  Ala Phe Leu Asn Thr  Glu Asp Lys 
    1460                 1465                 1470             


Gly Asp  Ser Leu Asp Ser Val  Glu Ala Leu Ile Lys  Lys His Glu 
    1475                 1480                 1485             


Asp Phe  Asp Lys Ala Ile Asn  Val Gln Glu Glu Lys  Ile Ala Ala 
    1490                 1495                 1500             


Leu Gln  Ala Phe Ala Asp Gln  Leu Ile Ala Ala Gly  His Tyr Ala 
    1505                 1510                 1515             


Lys Gly  Asp Ile Ser Ser Arg  Arg Asn Glu Val Leu  Asp Arg Trp 
    1520                 1525                 1530             


Arg Arg  Leu Lys Ala Gln Met  Ile Glu Lys Arg Ser  Lys Leu Gly 
    1535                 1540                 1545             


Glu Ser  Gln Thr Leu Gln Gln  Phe Ser Arg Asp Val  Asp Glu Ile 
    1550                 1555                 1560             


Glu Ala  Trp Ile Ser Glu Lys  Leu Gln Thr Ala Ser  Asp Glu Ser 
    1565                 1570                 1575             


Tyr Lys  Asp Pro Thr Asn Ile  Gln Ser Lys His Gln  Lys His Gln 
    1580                 1585                 1590             


Ala Phe  Glu Ala Glu Leu His  Ala Asn Ala Asp Arg  Ile Arg Gly 
    1595                 1600                 1605             


Val Ile  Asp Met Gly Asn Ser  Leu Ile Glu Arg Gly  Ala Cys Ala 
    1610                 1615                 1620             


Gly Ser  Glu Asp Ala Val Lys  Ala Arg Leu Ala Ala  Leu Ala Asp 
    1625                 1630                 1635             


Gln Trp  Gln Phe Leu Val Gln  Lys Ser Ala Glu Lys  Ser Gln Lys 
    1640                 1645                 1650             


Leu Lys  Glu Ala Asn Lys Gln  Gln Asn Phe Asn Thr  Gly Ile Lys 
    1655                 1660                 1665             


Asp Phe  Asp Phe Trp Leu Ser  Glu Val Glu Ala Leu  Leu Ala Ser 
    1670                 1675                 1680             


Glu Asp  Tyr Gly Lys Asp Leu  Ala Ser Val Asn Asn  Leu Leu Lys 
    1685                 1690                 1695             


Lys His  Gln Leu Leu Glu Ala  Asp Ile Ser Ala His  Glu Asp Arg 
    1700                 1705                 1710             


Leu Lys  Asp Leu Asn Ser Gln  Ala Asp Ser Leu Met  Thr Ser Ser 
    1715                 1720                 1725             


Ala Phe  Asp Thr Ser Gln Val  Lys Asp Lys Arg Asp  Thr Ile Asn 
    1730                 1735                 1740             


Gly Arg  Phe Gln Lys Ile Lys  Ser Met Ala Ala Ser  Arg Arg Ala 
    1745                 1750                 1755             


Lys Leu  Asn Glu Ser His Arg  Leu His Gln Phe Phe  Arg Asp Met 
    1760                 1765                 1770             


Asp Asp  Glu Glu Ser Trp Ile  Lys Glu Lys Lys Leu  Leu Val Gly 
    1775                 1780                 1785             


Ser Glu  Asp Tyr Gly Arg Asp  Leu Thr Gly Val Gln  Asn Leu Arg 
    1790                 1795                 1800             


Lys Lys  His Lys Arg Leu Glu  Ala Glu Leu Ala Ala  His Glu Pro 
    1805                 1810                 1815             


Ala Ile  Gln Gly Val Leu Asp  Thr Gly Lys Lys Leu  Ser Asp Asp 
    1820                 1825                 1830             


Asn Thr  Ile Gly Lys Glu Glu  Ile Gln Gln Arg Leu  Ala Gln Phe 
    1835                 1840                 1845             


Val Glu  His Trp Lys Glu Leu  Lys Gln Leu Ala Ala  Ala Arg Gly 
    1850                 1855                 1860             


Gln Arg  Leu Glu Glu Ser Leu  Glu Tyr Gln Gln Phe  Val Ala Asn 
    1865                 1870                 1875             


Val Glu  Glu Glu Glu Ala Trp  Ile Asn Glu Lys Met  Thr Leu Val 
    1880                 1885                 1890             


Ala Ser  Glu Asp Tyr Gly Asp  Thr Leu Ala Ala Ile  Gln Gly Leu 
    1895                 1900                 1905             


Leu Lys  Lys His Glu Ala Phe  Glu Thr Asp Phe Thr  Val His Lys 
    1910                 1915                 1920             


Asp Arg  Val Asn Asp Val Cys  Thr Asn Gly Gln Asp  Leu Ile Lys 
    1925                 1930                 1935             


Lys Asn  Asn His His Glu Glu  Asn Ile Ser Ser Lys  Met Lys Gly 
    1940                 1945                 1950             


Leu Asn  Gly Lys Val Ser Asp  Leu Glu Lys Ala Ala  Ala Gln Arg 
    1955                 1960                 1965             


Lys Ala  Lys Leu Asp Glu Asn  Ser Ala Phe Leu Gln  Phe Asn Trp 
    1970                 1975                 1980             


Lys Ala  Asp Val Val Glu Ser  Trp Ile Gly Glu Lys  Glu Asn Ser 
    1985                 1990                 1995             


Leu Lys  Thr Asp Asp Tyr Gly  Arg Asp Leu Ser Ser  Val Gln Thr 
    2000                 2005                 2010             


Leu Leu  Thr Lys Gln Glu Thr  Phe Asp Ala Gly Leu  Gln Ala Phe 
    2015                 2020                 2025             


Gln Gln  Glu Gly Ile Ala Asn  Ile Thr Ala Leu Lys  Asp Gln Leu 
    2030                 2035                 2040             


Leu Ala  Ala Lys His Val Gln  Ser Lys Ala Ile Glu  Ala Arg His 
    2045                 2050                 2055             


Ala Ser  Leu Met Lys Arg Trp  Ser Gln Leu Leu Ala  Asn Ser Ala 
    2060                 2065                 2070             


Ala Arg  Lys Lys Lys Leu Leu  Glu Ala Gln Ser His  Phe Arg Lys 
    2075                 2080                 2085             


Val Glu  Asp Leu Phe Leu Thr  Phe Ala Lys Lys Ala  Ser Ala Phe 
    2090                 2095                 2100             


Asn Ser  Trp Phe Glu Asn Ala  Glu Glu Asp Leu Thr  Asp Pro Val 
    2105                 2110                 2115             


Arg Cys  Asn Ser Leu Glu Glu  Ile Lys Ala Leu Arg  Glu Ala His 
    2120                 2125                 2130             


Asp Ala  Phe Arg Ser Ser Leu  Ser Ser Ala Gln Ala  Asp Phe Asn 
    2135                 2140                 2145             


Gln Leu  Ala Glu Leu Asp Arg  Gln Ile Lys Ser Phe  Arg Val Ala 
    2150                 2155                 2160             


Ser Asn  Pro Tyr Thr Trp Phe  Thr Met Glu Ala Leu  Glu Glu Thr 
    2165                 2170                 2175             


Trp Arg  Asn Leu Gln Lys Ile  Ile Lys Glu Arg Glu  Leu Glu Leu 
    2180                 2185                 2190             


Gln Lys  Glu Gln Arg Arg Gln  Glu Glu Asn Asp Lys  Leu Arg Gln 
    2195                 2200                 2205             


Glu Phe  Ala Gln His Ala Asn  Ala Phe His Gln Trp  Ile Gln Glu 
    2210                 2215                 2220             


Thr Arg  Thr Tyr Leu Leu Asp  Gly Ser Cys Met Val  Glu Glu Ser 
    2225                 2230                 2235             


Gly Thr  Leu Glu Ser Gln Leu  Glu Ala Thr Lys Arg  Lys His Gln 
    2240                 2245                 2250             


Glu Ile  Arg Ala Met Arg Ser  Gln Leu Lys Lys Ile  Glu Asp Leu 
    2255                 2260                 2265             


Gly Ala  Ala Met Glu Glu Ala  Leu Ile Leu Asp Asn  Lys Tyr Thr 
    2270                 2275                 2280             


Glu His  Ser Thr Val Gly Leu  Ala Gln Gln Trp Asp  Gln Leu Asp 
    2285                 2290                 2295             


Gln Leu  Gly Met Arg Met Gln  His Asn Leu Glu Gln  Gln Ile Gln 
    2300                 2305                 2310             


Ala Arg  Asn Thr Thr Gly Val  Thr Glu Glu Ala Leu  Lys Glu Phe 
    2315                 2320                 2325             


Ser Met  Met Phe Lys His Phe  Asp Lys Asp Lys Ser  Gly Arg Leu 
    2330                 2335                 2340             


Asn His  Gln Glu Phe Lys Ser  Cys Leu Arg Ser Leu  Gly Tyr Asp 
    2345                 2350                 2355             


Leu Pro  Met Val Glu Glu Gly  Glu Pro Asp Pro Glu  Phe Glu Ala 
    2360                 2365                 2370             


Ile Leu  Asp Thr Val Asp Pro  Asn Arg Asp Gly His  Val Ser Leu 
    2375                 2380                 2385             


Gln Glu  Tyr Met Ala Phe Met  Ile Ser Arg Glu Thr  Glu Asn Val 
    2390                 2395                 2400             


Lys Ser  Ser Glu Glu Ile Glu  Ser Ala Phe Arg Ala  Leu Ser Ser 
    2405                 2410                 2415             


Glu Gly  Lys Pro Tyr Val Thr  Lys Glu Glu Leu Tyr  Gln Asn Leu 
    2420                 2425                 2430             


Thr Arg  Glu Gln Ala Asp Tyr  Cys Val Ser His Met  Lys Pro Tyr 
    2435                 2440                 2445             


Val Asp  Gly Lys Gly Arg Glu  Leu Pro Thr Ala Phe  Asp Tyr Val 
    2450                 2455                 2460             


Glu Phe  Thr Arg Ser Leu Phe  Val Asn 
    2465                 2470         


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  4

Ala Asp Glu Leu Ala Ser Asp Val Ala Gly 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  5

Ala Ala Leu Thr Ser Glu Glu Val Gly Ala 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  6

Gln Gln Val Ala Pro Thr Asp Asp Glu Thr 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  7

Met Met Pro Arg Asp Glu Thr Asp Ser Lys 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  8

Ser Lys Thr Ala Ser Pro Trp Lys Ser Ala 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  9

Tyr Gly Met Met Pro Arg Asp Glu Thr Asp 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  10

Gln Glu Val Tyr Gly Met Met Pro Arg Asp 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  11

Glu Val Tyr Gly Met Met Pro Arg Asp Glu 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  12

Gly Met Met Pro Arg Asp Glu Thr Asp Ser 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  13

Ser Arg Glu Thr Glu Asn Val Lys Ser Ser 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  14

Thr Glu Asp Lys Gly Asp Ser Leu Asp Ser 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  15

Met Val Glu Glu Ser Gly Thr Leu Glu Ser 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  16

Arg Asp Glu Thr Asp Ser Lys Thr Ala Ser 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  17

Pro Arg Asp Glu Thr Asp Ser Lys Thr Ala 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  18

Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  19

Asn Thr Glu Asp Lys Gly Asp Ser Leu Asp 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  20

Val Gln Ala Val Gln Gln Gln Glu Val Tyr 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  21

Ser Ala His Glu Val Gln Arg Phe His Arg 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  22

Ala Ala Ser Ala Gly Val Pro Tyr His Gly 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  23

Pro Val Ser Pro Val Gly Ala Glu Gly Pro 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  24

Arg Ser Thr Glu Ser Ala His Ala Ala Thr 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  25

Asp Phe Asp Ser Leu Glu Ile Gln Gly Gln 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  26

Pro Asp Ser Asp Trp Asp Asn Asp Ser Ser 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  27

His Leu Leu Ala Ser Ala Asp Thr Gly Arg 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  28

Thr Leu Ser Arg Thr Pro Glu Val Gln Ser 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  29

His Thr Glu Met Pro Gly Thr Leu Gln Ala 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  30

Gln Ala Gln Leu His Ser Asp Asp Tyr Gly 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  31

Gln Gln Gln Glu Val Gly Met Met Pro Arg 
1               5                   10  


<210>  32
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  32

Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp 
1               5                   10      


<210>  33
<211>  7672
<212>  DNA
<213>  Homo sapiens

<400>  33
gaggctcctc ggtccttcag cacccctcgg cccgacgcac ccacgcccct caccccccga       60

gagccgaaaa tggacccaag tggggtcaaa gtgctggaaa cagcagagga catccaggag      120

aggcggcagc aggtcctaga ccgataccac cgcttcaagg aactctcaac ccttaggcgt      180

cagaagctgg aagattccta tcgattccag ttctttcaaa gagatgctga agagctggag      240

aaatggatac aggaaaaact tcagattgca tctgatgaga attataaaga cccaaccaac      300

ttgcagggaa agcttcagaa gcatcaagca tttgaagctg aagtgcaggc caactcagga      360

gccattgtta agctggatga aactggaaac ctgatgatct cagaagggca ttttgcatct      420

gaaaccatac ggacccgttt gatggagctg caccgccagt gggaattact tttggagaag      480

atgcgagaaa aaggaatcaa actgctgcag gcccagaagt tggtgcagta cttacgagaa      540

tgtgaggacg tgatggactg gatcaatgac aaggaagcaa ttgttacttc tgaagagctg      600

ggccaggatc tggagcatgt agaggtttta cagaagaaat ttgaagagtt tcaaacagat      660

atggctgctc atgaagaaag agttaatgaa gtgaaccagt ttgctgccaa actcatacag      720

gagcagcacc ctgaggagga actgatcaag actaagcagg atgaagtcaa tgcagcctgg      780

cagcggctga agggcctggc tctgcagagg caggggaagc tctttggggc agcagaagtt      840

cagcgcttta acagggatgt ggatgagact atcagttgga ttaaggaaaa ggagcagtta      900

atggcctctg atgattttgg ccgagacctg gcaagtgttc aggctctgct tcggaagcac      960

gagggtctgg agagagatct tgctgctcta gaagacaagg tcaaagccct gtgtgctgag     1020

gctgaccgcc tgcaacagtc ccaccctctg agtgcaacac agattcaagt gaagcgagag     1080

gaactgatta caaactggga gcagatccgc accttggcgg cagagagaca tgcacggctc     1140

aatgattcat acaggcttca acgcttcctt gctgacttcc gtgacctcac cagctgggtg     1200

actgagatga aagccctcat caatgcagat gagcttgcca gtgatgtggc tggggctgaa     1260

gccctgctag atagacacca agagcacaag ggtgaaattg atgcccatga agacagcttc     1320

aaatctgcag atgaatctgg acaggcactg cttgctgctg gtcactatgc ctcagatgaa     1380

gtgagggaga agctgaccgt cctttccgag gagagagcgg cgctgctgga gctgtgggag     1440

ctgcgcaggc agcagtacga gcagtgcatg gacctgcagc tcttctaccg ggacactgag     1500

caggtggaca actggatgag caagcaggag gcgttcctgt tgaatgaaga cttgggagat     1560

tccttggata gtgtggaagc gcttcttaag aagcacgaag actttgagaa atcccttagt     1620

gcccaggagg aaaagattac agcattagat gaatttgcaa ccaagctaat tcagaacaac     1680

cactatgcaa tggaagatgt ggccactcgc cgagatgctc tgttgagccg ccgcaatgcc     1740

cttcacgaga gagccatgcg tcgccgggcc cagctagccg attctttcca tctgcagcag     1800

tttttccgtg attctgatga gctcaagagt tgggtcaatg agaagatgaa aactgccaca     1860

gatgaagctt ataaagatcc atccaaccta caaggaaaag tacagaagca tcaggctttt     1920

gaggctgagc tctcagcaaa ccagagccga attgatgcct tggagaaagc tggccaaaag     1980

ctgattgatg tcaaccacta tgccaaggat gaagtggcag ctcgtatgaa tgaggtgatc     2040

agtttgtgga agaaactgct agaggccact gaactgaaag gaataaagct tcgtgaagcc     2100

aaccagcaac agcaatttaa tcgcaatgtt gaggatattg aattgtggct atatgaagta     2160

gaaggtcact tggcttcgga tgattacggc aaagatctta ccaatgtgca gaacctccag     2220

aagaaacatg ccctgctaga ggcagatgtg gctgctcacc aggaccgaat tgatggcatc     2280

accattcagg cccgccagtt ccaagatgct ggccattttg atgcagaaaa catcaagaag     2340

aaacaggaag ccctcgtggc tcgctatgag gcactcaagg agcccatggt tgcccggaag     2400

cagaagctgg ccgattctct gcggttgcag cagctcttcc gggatgttga ggatgaggag     2460

acgtggattc gagagaaaga gcccattgcc gcatctacca acagaggtaa ggatttaatt     2520

ggggtccaga atctgctaaa gaaacatcaa gccttacaag cagaaattgc tggacatgaa     2580

ccacgcatca aagcagttac acagaagggg aatgccatgg tggaggaagg ccattttgct     2640

gcagaggatg tgaaggccaa gcttcacgag ctgaaccaaa agtgggaggc actgaaagcc     2700

aaagcttccc agcgtcggca ggacctggag gactctctgc aggcccagca gtactttgct     2760

gatgctaacg aggctgaatc ctggatgcgg gagaaggaac ccattgtggg cagcactgac     2820

tatggcaagg acgaagactc tgctgaggct ctactgaaga aacacgaagc tttgatgtca     2880

gatctcagtg cctacggcag cagcatccag gctttgcgag aacaagcaca gtcctgccgg     2940

caacaagtgg cccccacgga tgatgagact gggaaggagc tggtcttggc tctctacgac     3000

tatcaggaga agagtccccg agaggtcacc atgaagaagg gagatatcct taccttactc     3060

aacagcacca acaaggattg gtggaaagtg gaagtgaacg atcgtcaggg ttttgtgccg     3120

gctgcgtacg tgaagaaatt ggaccccgcc cagtcagcct cccgggagaa tctcctggag     3180

gagcaaggca gcatagcact gcggcaggag cagattgaca atcagacacg cataactaag     3240

gaggccggca gtgtatctct gcgtatgaag caggtggaag aactatatca ttctctgctg     3300

gaactgggtg agaagcgtaa aggcatgttg gagaagagtt gcaagaagtt tatgttgttc     3360

cgtgaagcga atgaactaca gcaatggatc aatgagaagg aagccgctct gacaagtgag     3420

gaggtcggag cagacttgga gcaggttgag gtgctccaga agaagtttga tgacttccag     3480

aaggacctga aggccaatga gtcacggttg aaggacatta acaaggtagc tgaagacctg     3540

gagtctgaag gtctcatggc agaggaggtg caggctgtgc aacaacagga agtgtatggc     3600

atgatgccca gggatgaaac tgattccaag acagcctccc cgtggaagtc tgctcgtctg     3660

atggttcaca ccgtggccac ctttaattcc atcaaggagc tgaatgagcg ctggcggtcc     3720

ctacagcagc tggccgagga acggagccag ctcttgggca gcgcccatga agtacagagg     3780

ttccacagag atgctgatga aaccaaagaa tggattgaag agaagaatca agctctaaac     3840

acagacaatt atggacatga tctcgccagt gtccaggccc tgcaacgcaa gcatgagggc     3900

ttcgagaggg accttgcggc tctcggtgac aaggtaaact cccttggtga aacagcagag     3960

cgcctgatcc agtcccatcc cgagtcagca gaagacctgc aggaaaagtg cacagagtta     4020

aaccaggcct ggagcagcct ggggaaacgt gcagatcagc gcaaggcaaa gttgggtgac     4080

tcccacgacc tgcagcgctt ccttagcgat ttccgggacc tcatgtcttg gatcaatgga     4140

atacgggggt tggtgtcctc agatgagcta gccaaggatg tcaccggagc tgaggcattg     4200

ctggagcgac accaggaaca ccggacagaa atcgatgcca gggctggcac tttccaggca     4260

tttgagcagt ttggacagca gctgttggct cacggacact atgccagccc tgagatcaag     4320

cagaaacttg atattcttga ccaggagcgt gcagacctgg agaaggcctg ggttcagcgc     4380

aggatgatgc tggatcagtg ccttgaactg cagctgttcc atcgggactg tgagcaagct     4440

gagaactgga tggctgcccg ggaggccttc ttgaataccg aagacaaagg agactcactg     4500

gacagcgtag aggctctgat caaaaaacat gaagactttg acaaagcgat taacgtccag     4560

gaagagaaga ttgctgctct gcaggccttt gccgaccagc tcatcgctgc cggccattat     4620

gccaagggag acatttctag ccggcgcaat gaggtcttgg acaggtggcg acgtctgaaa     4680

gcccagatga ttgagaaaag gtcaaagcta ggagaatctc aaaccctcca acagttcagc     4740

cgggatgtgg atgagattga ggcttggatc agtgaaaaat tgcaaacagc gagtgatgag     4800

tcgtacaagg atcccaccaa catccagctt tccaagctgc tgagcaagca ccagaagcac     4860

caggcttttg aagcagagct gcatgccaac gctgaccgga tccgtggggt tatcgacatg     4920

ggcaactccc tcattgaacg tggagcctgt gccggcagtg aggatgctgt caaggcccgc     4980

ctggctgcct tagctgacca gtggcagttc ttggtgcaaa agtcagcgga aaagagccag     5040

aaactgaaag aagccaacaa gcagcagaac ttcaacacag ggatcaagga ctttgacttc     5100

tggctgtctg aggtggaggc cctgctggca tccgaagatt atggcaaaga cctggcttct     5160

gtgaacaacc tgctgaaaaa gcatcaactg ctggaagcag atatatctgc ccatgaggat     5220

cgcctgaagg acctgaacag ccaggcagac agcctgatga ccagcagtgc cttcgacacc     5280

tcccaagtaa aggacaagag ggacaccatc aacgggcgct tccagaagat caagagcatg     5340

gcggcctccc ggcgagccaa gctgaatgaa tcccatcgcc tgcaccagtt cttccgggac     5400

atggatgacg aggagtcctg gatcaaggag aagaagctgc tggtgggctc agaggactac     5460

ggccgggacc taaccggcgt gcagaacctg aggaagaagc acaagcggct ggaagcagaa     5520

ctggctgcgc atgagccggc tattcagggt gtcctggaca ctggcaagaa gctgtccgat     5580

gacaacacca tcgggaaaga ggagatccag cagcggctgg cgcagtttgt ggagcactgg     5640

aaagagctga agcagctggc agctgcccgg ggtcagcggc tggaagagtc cttggaatat     5700

cagcagtttg tagccaatgt ggaagaggaa gaagcctgga tcaatgagaa aatgaccctg     5760

gtggccagcg aagattatgg cgacactctt gccgccatcc agggcttact gaagaaacat     5820

gaagcttttg agacagactt caccgtccac aaggatcgcg tgaatgatgt ctgcaccaat     5880

ggacaagacc tcattaagaa gaacaatcac catgaggaga acatctcttc aaagatgaag     5940

ggcctgaacg ggaaagtgtc agacctggag aaagctgcag cccagagaaa ggcgaagctg     6000

gatgagaact cggccttcct tcagttcaac tggaaggcgg acgtggtgga gtcctggatc     6060

ggtgaaaagg agaacagctt gaagacagat gattatggcc gagacctgtc ttctgtgcag     6120

acgctcctca ccaaacagga aacttttgac gctgggctgc aggccttcca gcaggaaggc     6180

attgccaaca tcactgccct caaagatcag cttctcgccg ccaaacacgt tcagtccaag     6240

gccatcgagg cccggcacgc ctccctcatg aagaggtgga gccagcttct ggccaactca     6300

gccgcccgca agaagaagct tctggaggct cagagtcact tccgcaaggt ggaggacctc     6360

ttcctgacct tcgccaaaaa ggcttctgcc ttcaacagct ggtttgaaaa tgcagaggag     6420

gacttaacag accccgtgcg ctgcaactcc ttggaagaaa tcaaagcttt gcgcgaggcc     6480

cacgacgcct tccgctcctc cctcagctct gcccaggctg acttcaacca gctggccgag     6540

ctggaccgcc agatcaagag cttccgcgta gcctccaacc cctacacctg gtttaccatg     6600

gaggccctgg aggagacctg gaggaaccta cagaaaatca tcaaggagag ggagctggag     6660

ctgcagaagg aacagcggcg gcaggaggag aacgacaagc tgcgccagga gtttgcccag     6720

cacgccaacg ccttccacca gtggatccaa gagaccagga catacctcct cgatgggtcc     6780

tgtatggtgg aagagtcggg gaccctcgaa tcccagcttg aagctaccaa acgcaagcac     6840

caggaaatcc gagccatgag aagtcagctc aaaaagatcg aggacctggg ggccgccatg     6900

gaggaggccc tcatcctgga caacaagtac acggagcaca gcaccgtggg cctcgcccag     6960

cagtgggacc agctggacca gctgggcatg cgcatgcagc acaacctgga gcagcagatc     7020

caggccagga acacaacagg tgtgactgag gaggccctca aagaattcag catgatgttt     7080

aaacactttg acaaggacaa gtctggcagg ctgaaccatc aggagttcaa atcttgcctg     7140

cgctccctgg gctatgacct gcccatggtg gaggaagggg aacctgaccc tgagttcgag     7200

gcaatcctgg acacggtgga tccgaacaga gatggccatg tctccttgca agaatacatg     7260

gctttcatga tcagccgcga aactgagaac gtcaagtcca gcgaggagat tgagagcgcc     7320

ttccgggccc tcagctcaga gggaaagcct tacgtgacca aggaggagct ctaccagaac     7380

ctgacccggg aacaagccga ctactgcgtc tcccacatga agccctacgt ggacggcaag     7440

ggccgcgagc tccccaccgc gttcgactac gtggagttca cccgctcgct tttcgtgaac     7500

tgagccactc cctgggtcac ccacccctcg ctgcttgccc tgcgtcgcct tgctgcatgt     7560

ccgctcctct gtgtgctctc actttccact gtaaccttaa gcctgcttag cttggaataa     7620

gacttaggag aaaatggtgc ttcactaacc cgcttccggt ccagtcacaa tc             7672


