                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Nebraska
       BATRA, SURINDER K.
       JAIN, MANEESH
       PONNUSAMY, MOORTHY P.
 
<120>  COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF CANCER

<130>  UNEBP002WO

<140>  PCT/US2012/041007
<141>  2012-06-06

<150>  US 61/493,688
<151>  2011-06-06

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  1

Trp Val Asn Ala His Ala Tyr Pro Ala Gln Trp Thr Leu Gly Ser Asn 
1               5                   10                  15      


Thr Tyr Gln Ala Ile Leu Ser Thr Asp Gly Ser Arg Ser Tyr Ala Leu 
            20                  25                  30          


Phe Leu Tyr Gln Ser Gly Gly Met Gln Trp Asp Val Ala Gln Arg Ser 
        35                  40                  45              


Gly Asn Pro Val Leu Met Gly Phe Ser Ser Gly Asp Gly Tyr Phe Glu 
    50                  55                  60                  


Asn Ser Pro Leu Met Ser Gln Pro Val Trp Glu Arg Tyr Arg Pro Asp 
65                  70                  75                  80  


Arg Phe Leu Asn Ser Asn Ser Gly Leu Gln Gly Leu Gln Phe Tyr Arg 
                85                  90                  95      


Leu His Arg Glu Glu Arg Pro Asn Tyr Arg Leu Glu Cys Leu Gln Trp 
            100                 105                 110         


Leu Lys Ser Gln Pro Arg Trp Pro Ser Trp Gly Trp Asn Gln Val Ser 
        115                 120                 125             


Cys Pro Cys Ser Trp Gln Gln Gly Arg Arg Asp Leu Arg Phe Gln Pro 
    130                 135                 140                 


Val Ser Ile Gly Arg Trp Gly Leu Gly Ser Arg Gln Leu Cys Ser Phe 
145                 150                 155                 160 


Thr Ser Trp Arg Gly Gly Val Cys Cys Ser Tyr Gly Pro Trp Gly Glu 
                165                 170                 175     


Phe Arg Glu Gly Trp His Val Gln Arg Pro Trp Gln Leu Ala Gln Glu 
            180                 185                 190         


Leu Glu Pro Gln Ser Trp Cys Cys Arg Trp Asn Asp Lys Pro Tyr Leu 
        195                 200                 205             


Cys Ala Leu Tyr Gln Gln Arg Arg Pro His Val Gly Cys Ala Thr Tyr 
    210                 215                 220                 


Arg Pro Pro Gln Pro Ala Trp Met Phe Gly Asp Pro His Ile Thr Thr 
225                 230                 235                 240 


Leu Asp Gly Val Ser Tyr Thr Phe Asn Gly Leu Gly Asp Phe Leu Leu 
                245                 250                 255     


Val Gly Ala Gln Asp Gly Asn Ser Ser Phe Leu Leu Gln Gly Arg Thr 
            260                 265                 270         


Ala Gln Thr Gly Ser Ala Gln Ala Thr Asn Phe Ile Ala Phe Ala Ala 
        275                 280                 285             


Gln Tyr Arg Ser Ser Ser Leu Gly Pro Val Thr Val Gln Trp Leu Leu 
    290                 295                 300                 


Glu Pro His Asp Ala Ile Arg Val Leu Leu Asp Asn Gln Thr Val Thr 
305                 310                 315                 320 


Phe Gln Pro Asp His Glu Asp Gly Gly Gly Gln Glu Thr Phe Asn Ala 
                325                 330                 335     


Thr Gly Val Leu Leu Ser Arg Asn Gly Ser Glu Val Ser Ala Ser Phe 
            340                 345                 350         


Asp Gly Trp Ala Thr Val Ser Val Ile Ala Leu Ser Asn Ile Leu His 
        355                 360                 365             


Ala Ser Ala Ser Leu Pro Pro Glu Tyr Gln Asn Arg Thr Glu Gly Leu 
    370                 375                 380                 


Leu Gly Val Trp Asn Asn Asn Pro Glu Asp Asp Phe Arg Met Pro Asn 
385                 390                 395                 400 


Gly Ser Thr Ile Pro Pro Gly Ser Pro Glu Glu Met Leu Phe His Phe 
                405                 410                 415     


Gly Met Thr Trp Gln Ile Asn Gly Thr Gly Leu Leu Gly Lys Arg Asn 
            420                 425                 430         


Asp Gln Leu Pro Ser Asn Phe Thr Pro Val Phe Tyr Ser Gln Leu Gln 
        435                 440                 445             


Lys Asn Ser Ser Trp Ala Glu His Leu Ile Ser Asn Cys Asp Gly Asp 
    450                 455                 460                 


Ser Ser Cys Ile Tyr Asp Thr Leu Ala Leu Arg Asn Ala Ser Ile Gly 
465                 470                 475                 480 


Leu His Thr Arg Glu Val Ser Lys Asn Tyr Glu Gln Ala Asn Ala Thr 
                485                 490                 495     


Leu Asn Gln Tyr Pro Pro Ser Ile Asn Gly Gly Arg Val Ile Glu Ala 
            500                 505                 510         


Tyr Lys Gly Gln Thr Thr Leu Ile Gln Tyr Thr Ser Asn Ala Glu Asp 
        515                 520                 525             


Ala Asn Phe Thr Leu Arg Asp Ser Cys Thr Asp Leu Glu Leu Phe Glu 
    530                 535                 540                 


Asn Gly Thr Leu Leu Trp Thr Pro Lys Ser Leu Glu Pro Phe Thr Leu 
545                 550                 555                 560 


Glu Ile Leu Ala Arg Ser Ala Lys Ile Gly Leu Ala Ser Ala Leu Gln 
                565                 570                 575     


Pro Arg Thr Val Val Cys His Cys Asn Ala Glu Ser Gln Cys Leu Tyr 
            580                 585                 590         


Asn Gln Thr Ser Arg Val Gly Asn Ser Ser Leu Glu Val Ala Gly Cys 
        595                 600                 605             


Lys Cys Asp Gly Gly Thr Phe Gly Arg Tyr Cys Glu Gly Ser Glu Asp 
    610                 615                 620                 


Ala Cys Glu Glu Pro Cys Phe Pro Ser Val His Cys Val Pro Gly Lys 
625                 630                 635                 640 


Gly Cys Glu Ala Cys Pro Pro Asn Leu Thr Gly Asp Gly Arg His Cys 
                645                 650                 655     


Ala Ala Leu Gly Ser Ser Phe Leu Cys Gln Asn Gln Ser Cys Pro Val 
            660                 665                 670         


Asn Tyr Cys Tyr Asn Gln Gly His Cys Tyr Ile Ser Gln Thr Leu Gly 
        675                 680                 685             


Cys Gln Pro Met Cys Thr Cys Pro Pro Ala Phe Thr Asp Ser Arg Cys 
    690                 695                 700                 


Phe Leu Ala Gly Asn Asn Phe Ser Pro Thr Val Asn Leu Glu Leu Pro 
705                 710                 715                 720 


Leu Arg Val Ile Gln Leu Leu Leu Ser Glu Glu Glu Asn Ala Ser Met 
                725                 730                 735     


Ala Glu Val Asn Ala Ser Val Ala Tyr Arg Leu Gly Thr Leu Asp Met 
            740                 745                 750         


Arg Ala Phe Leu Arg Asn Ser Gln Val Glu Arg Ile Asp Ser Ala Ala 
        755                 760                 765             


Pro Ala Ser Gly Ser Pro Ile Gln His Trp Met Val Ile Ser Glu Phe 
    770                 775                 780                 


Gln Tyr Arg Pro Arg Gly Pro Val Ile Asp Phe Leu Asn Asn Gln Leu 
785                 790                 795                 800 


Leu Ala Ala Val Val Glu Ala Phe Leu Tyr His Val Pro Arg Arg Ser 
                805                 810                 815     


Glu Glu Pro Arg Asn Asp Val Val Phe Gln Pro Ile Ser Glu Glu Asp 
            820                 825                 830         


Val Arg Asp Val Thr Ala Leu Asn Val Ser Thr Leu Lys Ala Tyr Phe 
        835                 840                 845             


Arg Cys Asp Gly Tyr Lys Gly Tyr Asp Leu Val Tyr Ser Pro Gln Ser 
    850                 855                 860                 


Gly Phe Thr Cys Val Ser Pro Cys Ser Arg Gly Tyr Cys Asp His Gly 
865                 870                 875                 880 


Gly Gln Cys Gln His Leu Pro Ser Gly Pro Arg Cys Ser Cys Val Ser 
                885                 890                 895     


Phe Ser Ile Tyr Thr Ala Trp Gly Glu His Cys Glu His Leu Ser Met 
            900                 905                 910         


Lys Leu Asp Ala Phe Phe Gly Ile Phe Phe Gly Ala 
        915                 920                 


<210>  2
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Leu Lys Met Glu Thr Ser Gly Met Thr Thr Pro Ser Leu Lys Thr 
1               5                   10                  15      


Asp Gly Gly Arg Arg Thr Ala Thr Ser Pro Pro Pro Thr Thr Ser Gln 
            20                  25                  30          


Thr Ile Ile Ser Thr Ile Pro Ser Thr Ala Met His Thr Arg Ser Thr 
        35                  40                  45              


Ala Ala Pro Ile Pro Ile Leu Pro Glu Arg Gly Val Ser Leu Phe Pro 
    50                  55                  60                  


Tyr Gly Ala Asp Ala Gly Asp Leu Glu Phe Val Arg Arg Thr Val Asp 
65                  70                  75                  80  


Phe Thr Ser Pro Leu Phe Lys Pro Ala Thr Gly Phe Pro Leu Gly Ser 
                85                  90                  95      


Ser Leu Arg Asp Ser Leu Tyr Phe Thr Asp Asn Gly Gln Ile Ile Phe 
            100                 105                 110         


Pro Glu Ser Asp Tyr Gln Ile Phe Ser Tyr Pro Asn Pro Leu Pro Thr 
        115                 120                 125             


Gly Phe Thr Gly Arg Asp Pro Val Ala Leu Val Ala Pro Phe Trp Asp 
    130                 135                 140                 


Asp Ala Asp Phe Ser Thr Gly Arg Gly Thr Thr Phe Tyr Gln Glu Tyr 
145                 150                 155                 160 


Glu Thr Phe Tyr Gly Glu His Ser Leu Leu Val Gln Gln Ala Glu Ser 
                165                 170                 175     


Trp Ile Arg Lys Ile Thr Asn Asn Gly Gly Tyr Lys Ala Arg Trp Ala 
            180                 185                 190         


Leu Lys Val Thr Trp Val Asn Ala His Ala Tyr Pro Ala Gln Trp Thr 
        195                 200                 205             


Leu Gly Ser Asn Thr Tyr Gln Ala Ile Leu Ser Thr Asp Gly Ser Arg 
    210                 215                 220                 


Ser Tyr Ala Leu Phe Leu Tyr Gln Ser Gly Gly Met Gln Trp Asp Val 
225                 230                 235                 240 


Ala Gln Arg Ser Gly Lys Pro Val Leu Met Gly Phe Ser Ser Gly Asp 
                245                 250                 255     


Gly Phe Phe Glu Asn Ser Pro Leu Met Ser Gln Pro Val Trp Glu Arg 
            260                 265                 270         


Tyr Arg Pro Asp Arg Phe Leu Asn Ser Asn Ser Gly Leu Gln Gly Leu 
        275                 280                 285             


Gln Phe Tyr Gly Leu His Arg Glu Glu Arg Pro Asn Tyr Arg Leu Glu 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Ser Gln Pro Arg Trp Pro Ser Trp Gly Trp 
305                 310                 315                 320 


Asn Gln Val Ser Cys Pro Cys Ser Trp Gln Gln Gly Arg Arg Asp Leu 
                325                 330                 335     


Arg Phe Gln Pro Val Ser Ile Gly Arg Trp Gly Leu Gly Ser Arg Gln 
            340                 345                 350         


Leu Cys Ser Phe Thr Ser Trp Arg Gly Gly Val Cys Cys Ser Tyr Gly 
        355                 360                 365             


Pro Trp Gly Glu Phe Arg Glu Gly Trp His Val Gln Arg Pro Trp Gln 
    370                 375                 380                 


Leu Ala Gln Glu Leu Glu Pro Gln Ser Trp Cys Cys Arg Trp Asn Asp 
385                 390                 395                 400 


Lys Pro Tyr Leu Cys Ala Leu Tyr Gln Gln Arg Arg Pro His Val Gly 
                405                 410                 415     


Cys Ala Thr Tyr Arg Pro Pro Gln Pro Ala Trp Met Phe Gly Asp 
            420                 425                 430     


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity tag

<400>  4

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity tag

<400>  5

His His His His 
1               


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity tag

<400>  6

His His His His His 
1               5   


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity tag

<400>  7

His His His His His His 
1               5       


<210>  8
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  8

Gly Phe Leu Gly 
1               


