                         SEQUENCE LISTING

<110>  Davidson, Robert
 
<120>  MODULATION OF METABOLIC PATHWAYS FOR IMPROVING BIOPROCESS 
       PERFORMANCE AND SECRETED PROTEIN PRODUCTIVITY OF YEAST

<130>  23078

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  9334
<212>  DNA
<213>  Pichia pastoris

<400>  1
cgttatgttg gatgaatgac tagtatgctg tttggggaaa tcagggttgg ggcagtcctt       60

tgagtggtac caaatgacca atggttgagg acggacgaat gtacagtccc gggtctacga      120

aatatgcata agactgtcta acaacaagag gggttggggc gatcgcgcta aacaacatct      180

gctttgttgt acattttgta cgtcattcca actaccaacc ttctcggaag ccaacctctt      240

atcggataga gcggaacggg aagaacccat ggacggagga taacagacat tggccagcga      300

gcgagattga aggaggagaa aaatcgtaaa cttgatacac aataacagat ttggaggggt      360

ggtttttatc taattaatct gctcgctctt cctcctctcc tctcctcact ccacttctac      420

gttcattccc tttctgtacc cccgttctgt gatgtaagac gtgacgatga ttggtcaaat      480

ctacagttct gcttattccc ccaccaccgc accctcattg ggagtgttca agtggtgctg      540

gctggtgtat ctctcgatgt cgtatgattc tgataggaga atgtatgagt tctacgtttg      600

gcattgatgc cagctactgc gcgcaatccg cacccagcac cccttaattc ttttgatgat      660

gccccgcttc actgctcggg tgtgctctcg ggagtatttc cgattagctc aactctcacg      720

ttcaaagtta aactttattg acgaagagga actttctaaa cggctggaca gaaacttaga      780

ttagggaatg acggtgttta cacctccaga ttctgttcca acacgatatg gacttgtagc      840

tcgcttcgat caaatttttc aagtgtgaac gtctcctgca gcagtctttc atcatacata      900

tgaaaaattt ttaaggagtt ctttacccca gttttcagat ttttttttct ctcttcagct      960

gtacgcagta ctagaatcag cgacctataa acacgaaact actatacaat ccaacactag     1020

ctgtgtatct attccactct ctccaatact gtttccccaa tcctaccact aacgttcggt     1080

tgagccctct ctattacccc atattttact atatttatct tgttgtcttt ttatgcacgt     1140

attatgcaca tagtatgtag gtcgcagagg attcacccac attgaaaaat gtttcctata     1200

aatcaaactc ctcatatctg cagtgacagg tttctccccc acaatcttcg tcccttcaat     1260

atccgggcgt tgccatttct gagtgcagca gtgtttcctg caaagccatc aagaggagct     1320

acatgctctc attttttggt tttgtatgtc cgacggggtt cgtaaactgg ttcctccttt     1380

ccttcctgtt ccatttattg gtcaaaaaac aggtctttcc taaaccttat gtcaatgacc     1440

taccacatag tgttgcatct gaagattgag ggggtgtaca tcaccatccc accctaggat     1500

gtcctacagg taaacagata gccactacga tgatcatcca taaacaaaaa tcaaatttaa     1560

tagacttaca caactactaa cccgttagtg gccaaatcta cttatagttt gtcgtgcttt     1620

ggttttccct tcaaatcggt gaattcgtaa aggatttgag gactagcctt aatagagttg     1680

acgtatgcag caaccttctc accaatcttc tcaggagtgt atccgaagta tttgtagaca     1740

tcctcaacag gaagagactt accaaaggtg ttcatggtgt aaccagcagt ggcgtatctc     1800

tcccatccgt atgcgacata ggcctcaaca acgacagttg gaacctctcc tcttctaagg     1860

acagaacgtc tgtatgccag ggattgttgg tcaaacagtc tctgacatgg gaatgacaga     1920

actctgacct tccatccctt ctgttgtctt agcaaacgag cagttttgac ggcaaactcc     1980

aattcggaac cagcaccaat taattggacg tctggcttac cctcacagtc ttcaacgacg     2040

taaccacctc ttttggctcc ctcagccgaa gtcttacctg ggtattgctc aacctcgtgt     2100

ctggacagag agaacaaggt ggagtgctcg agctcaacag ctacttcaaa cagagctgca     2160

acctcggtag catcggctgg tctaatgtag tagaagttgg gcatagctct gaataatgaa     2220

gacaaagcaa taggctggtg cgttggacca tcttcaccag ctccgatgga gtcgtgtgta     2280

gcaatgtgaa ttgctttcaa ctcttgaagt gcagccatac gcaaggcagg tgctgcatac     2340

aggtagaaca tgtagaaagt tgaggtaata ggcaagaaag tacccttgtt gtatgcagcc     2400

aaaccattgg caatagcaca catagagtgt tctctgatac caaactcaat atatctacca     2460

gagtagtcac cacccaatcc acagaaagtt tgtaacttag ggttgaagaa gtacttaact     2520

cctccccagt tcaaaagaat ggacacggac aagtcaccag aaccagcaat aacctgagga     2580

aggttttgtc ccagagatct aacaatttct ctagcagagg ttctggtagc agttggctcg     2640

gttggtttgt cctgtggaat gaaactcttc cagttctttg gaagttcacc tctaatacgg     2700

gcctttaatt cctcaccttc ttgaggatag ttcttaacgt actcatccaa aagtttcttc     2760

cagttagcaa ctagttgatc accctcggct ggtttttcag caaagaaatc atagacctcc     2820

tgtgggaacc agaactttct agcgacatcg aaaccgtact tggccttcaa ctcccggata     2880

ccttcctcac caagagcaga accgtgagca gcgtggtggt taccgaaagc agaatcctgt     2940

ccaatttcag ttctaacgtt gatcagagtt ggtctctcat tctcagcctt ggcccattcg     3000

atggccttga caagggtagc aacatctcta gaaccattct cgacttcaat gacattccag     3060

ttctgagctc taaacttagc agaaatgtct tcggtgttgt taacatcgac ggaaccatca     3120

caacaaacct ggttgttgtc gtagatcaca ataaggttgt ccaaggccaa gtgaccagct     3180

aaggaaatcg attccaaagc aggtccctct tgcaaacaag catcaccaac aatagcatag     3240

atagtgttgt caacgacagg gaagccaggt ctgttgtaag tagcggccag gttctttgaa     3300

ccaatggcca taccgacagc gttagagata ccttgtccca ggggaccagt ggtaacctca     3360

acagcagggt tctcaatttc agggtgtcca ggagtcaatg agtgataatc ggaagagtgg     3420

taagattgaa gttgcttgac agtcatctcc ttcaaaccag ttaagtgctg gaacaagtat     3480

tggaacagac agacgtgacc gtttgacaag acaaaacgat ctctgttgaa gtagtctgga     3540

tcatttggag cgtacttcat ctggtacttc cacagagcga taccaatggc gaccataccc     3600

atggcagaac cagggtgacc accaccatac tgttcgacta agtcgagaac gtaacaacgg     3660

aaggttttga tgaccaattc atgaatgtca tcttgtgtcg atactgcttt tggaattcta     3720

gccatttttg atgtttgata gtttgataag agtgaacttt agtgtttaga ggggttataa     3780

tttgttgtaa ctggttttgg tcttaagtta aaacgaactt gttatattaa acacaacggt     3840

cactcaggat acaagaatag gaaagaaaaa ctttaaactg gggacatgtt gtctttatat     3900

aatttggcgg ttaaccctta atgcccgttt ccgtctcttc atgataacaa agctgcccat     3960

ctatgactga atgtggagaa gtatcggaac aacccttcac taaggatatc taggctaaac     4020

tcattcgcgc cttagatttc tccaaggtat cggttaagtt tcctctttcg tactggctaa     4080

cgatggtgtt gctcaacaaa gggatggaac ggcagctaaa gggagtgcat ggaatgactt     4140

taattggctg agaaagtgtt ctatttgtcc gaatttcttt tttctattat ctgttcgttt     4200

gggcggatct ctccagtggg gggtaaatgg aagatttctg ttcatggggt aaggaagctg     4260

aaatccttcg tttcttatag gggcaagtat actaaatctc ggaacattga atggggttta     4320

ctttcattgg ctacagaaat tattaagttt gttatggggt gaagttacca gtaattttca     4380

ttttttcact tcaacttttg gggtatttct gtggggtagc atagcttgac aggtaatatg     4440

atgtactatg ggataggcaa gtcttgtgtt tcagataccg ccaaacgtta aataggaccc     4500

tcttggtgac ttgctaactt agaaagtcat gcccaggtgt tacgtaatct tacttggtat     4560

gactttttga gtaacggact tgctagagtc cttaccagac ttccagttta gcaaaccaca     4620

gattgatctg tcctctggca tatctcaaac caatcaacac ccgtaaccct ttcatgaaac     4680

aactctagaa tgcgtcttat caacaggatt gcccaaaaca gtaattgggg cggtggaatc     4740

tacatgggag ttccatcgtt gtctcggttt ttctccctat aagctactct ggagacgaag     4800

taactaacac cctcaaatat cattatgtcc tggtcagggt tcaagaaagc cgtcaataga     4860

gctggaacgc aggtccttat gaagacaaac catcttgatg agagtctgga tgaagagttt     4920

gatttccagg agaagaactt ccggattatc caacaattta ctcaagagct ctacaatcga     4980

ctttcaagct tattggaaaa tcatcatagt tgtctaaagg ctaatctagc cgttgctacc     5040

actttgaact catattatgg aacctccact acggatggat ttgaaggaaa atatctggag     5100

atcgtcaaca ggataaaaga cgatgtgtta cccaattcag tggaaccgtt caattataca     5160

atattgcaac cgttagagac tcttaaacag tacaatgaag agtttgactt gttaataaaa     5220

aaacgttata gaaagaaatt ggactacgat atgctccaat ccaaattgtc aaaattgacc     5280

accgaaaaag aacaattgga atttgacaag aggaacaact cactagattc tcaaacggag     5340

cgtcacctag agtcagtttc caagtcaatt acagaaagtt tggaaacaga agaggagtat     5400

ctacaattga attccaaact taaagtcgag ctgtccgaat tcatgtcgct aaggctttct     5460

tacttggacc ccatttttga aagtttcatt aaagttcagt caaaaatttt catggacatt     5520

tatgacacat taaagagcgg actaccttat gttgattctc tatccaaaga ggattatcag     5580

tccaagatct tggactctag aatagataac attctgtcga aaatggaagc gctgaacctt     5640

caagcttaca ttgatgatta gagcaatgat ataaacaaca attgagtgac aggtctactt     5700

tgttctcaaa aggccataac catctgtttg catctcttat caccacacca tcctcctcat     5760

ctggccttca attgtgggga acaactagca tcccaacacc agactaactc cacccagatg     5820

aaaccagttg tcgcttacca gtcaatgaat gttgagctaa cgttccttga aactcgaatg     5880

atcccagcct tgctgcgtat catccctccg ctattccgcc gcttgctcca accatgtttc     5940

cgcctttttc gaacaagttc aaatacctat ctttggcagg acttttcctc ctgccttttt     6000

tagcctcagg tctcggttag cctctaggca aattctggtc ttcataccta tatcaacttt     6060

tcatcagata gcctttgggt tcaaaaaaga actaaagcag gatgcctgat atataaatcc     6120

cagatgatct gcttttgaaa ctattttcag tatcttgatt cgtttactta caaacaacta     6180

ttgttgattt tatctggaga ataatcgaac aaaatggcta gaattcccaa agcagtttct     6240

tacaatgatg acatccatga cttggtcatc aaaaccttcc gttgttacgt tctcgactta     6300

gtcgaacagt atggtggtgg tcaccctggt tctgccatgg gtatggtcgc cattggtatc     6360

gctctgtgga agtaccagat gaagtacgct ccaaatgatc cagactactt caacagagat     6420

cgttttgtct tgtcaaacgg tcacgtctgt ttgttccaat acttgttcca gcacttaact     6480

ggtttgaagg agatgactgt caagcaactt caatcttacc actcttccga ttatcactca     6540

ttgactcctg gacaccctga aattgagaac cctgctgttg aggttaccac tggtcccctg     6600

ggacaaggta tctctaacgc tgtcggtatg gccattggtt caaagaacct ggccgctact     6660

tacaacagac ctggcttccc tgtcgttgac aacactatct atgctattgt tggtgatgct     6720

tgtttgcaag agggacctgc tttggaatcg atttccttag ccggtcactt ggccttggac     6780

aaccttattg tgatctacga caacaaccag gtttgttgtg atggttccgt cgatgttaac     6840

aacaccgaag acatctccgc aaagttcaga gctcagaact ggaatgttat cgacattgta     6900

gacggttcta gagatgtcgc taccattgtc aaggctatcg attgggccaa ggctgagact     6960

gagagaccaa ctctgatcaa cgttagaact gaaattggac aggattctgc tttcggtaac     7020

caccacgctg ctcacggttc tgctctaggt gaggaaggta tccgggagtt gaagactaag     7080

tacggtttta accctgccca aaagttctgg ttccctaaag aagtatacga cttctttgct     7140

gagaaaccag ctaaaggtga cgagttagta aagaactgga aaaagttagt tgatagctat     7200

gtcaaagagt accctcgtga gggacaagag ttcctttctc gtgttagagg tgagcttcca     7260

aagaactgga gaacttacat tcctcaagac aagcctaccg aaccaaccgc caccagaacc     7320

tctgctagag aaattgttag ggcccttgga aagaaccttc ctcaagttat tgccggttcc     7380

ggtgacttat ctgtctcaat tcttttgaac tgggacggag tgaagtactt cttcaaccct     7440

aagttacaga ctttctgtgg attaggtggt gactactctg gtagatatat tgagtttggt     7500

atcagagaac actctatgtg tgctattgcc aacggtttgg ctgcatacaa caagggtact     7560

ttcttgccta ttacctctac cttctacatg ttctacctgt atgcagcacc tgccttgcgt     7620

atggctgctc ttcaagagtt gaaagcgatt cacattgcta cacacgactc tattggagct     7680

ggtgaagatg gtccaaccca ccagcctatt gctttgtctt cattattcag agctatgccc     7740

aacttctact acatgagacc agccgatgct accgaagttg cagctctgtt tgaagtggct     7800

gttgagcttg aacactccac attgctttct ctgtccagac acgaggttga ccaataccca     7860

ggtaagactt ctgcccaagg agccaaaaga ggtggttacg ttgttgaaga ctgcgaagga     7920

aagccagatg tgcaactgat cggaactggt tccgagttgg aattcgctat taagactgct     7980

cgtttgctaa gacaacagaa gggatggaag gtcagagttc tgtcattccc atgtcagaga     8040

ttgtttgacg agcagtctat tacttacaga cgttccgtcc ttagaagagg agaagttcca     8100

actgtcgttg ttgaggccta tgtcgcatac ggatgggaga gatacgccac tgctggttac     8160

accatgaaca ccttcggtaa gtctcttcct gttgaggatg tctacaaata cttcggatac     8220

actcctgaga agattggtga gagagtggtt caatatgtca actctatcaa ggctagtcct     8280

caaatccttt acgaattcca cgacttgaag ggaaaaccaa agcatgacaa gttgtaaacg     8340

ggaagtcttt acagttttag ttaggagccc ttatatatga cagtaatgct agtacgtttt     8400

gttttgttta attaataact tagtttatgt tagcctagta tagactccat caattttttt     8460

tgttattacg taagccgcga tgataatatc tgatgaaaaa ttcctatcag aaaataattt     8520

atcaaaagtt tcatgcgata tgagactaag tagaataggg actcccaaag tgtcagtcac     8580

aagggtcatt cccgttcgta atgtggtgat agcgaggaga aaacctgtca gagcaagtaa     8640

caccgacgca aagacatggc taatgaaaga agagcagaga agaataagac agaaggagca     8700

ggagatgaaa caaaggctag aggaactaga aaggttcaaa acaaaagtac agaaatcata     8760

tataaggaaa gaggataggc atttggcaca agagatagaa aaggatcttg acataatcac     8820

tgatgattac aatttggaca gcgatgtaga cctggtcttt ggagaactca tgcaagcaga     8880

agagcagccc aaatcgttga agagtttacc aggagccagt gatgcaagtg ataacacaga     8940

taaatcggtg gaactgtttt cctttccatc tccgaatctg acgctacctg aaaaggtgat     9000

acaccatatt gggccactgg tgaagcacat cagtaatcct gaaaacattc aatgggggag     9060

acttttactg gatttggaaa aaaatcaggg gtttaacggt ctatctgccg tagatgttac     9120

cagactgatt caaaatatac ccaaagagga aaaatatcag catatgtctt tgattcatga     9180

aatgatgttt aacagtggga tcagtcctga tcggtacttg acagatttga tgatgactgc     9240

cttctctgaa aggagctact atgaaccatt ggttgaggct cttttccaag actatgacat     9300

caatggctgg gctccaacag attatacttt tgga                                 9334


<210>  2
<211>  2124
<212>  DNA
<213>  Pichia pastoris

<400>  2
atggctagaa ttccaaaagc agtatcgaca caagatgaca ttcatgaatt ggtcatcaaa       60

accttccgtt gttacgttct cgacttagtc gaacagtatg gtggtggtca ccctggttct      120

gccatgggta tggtcgccat tggtatcgct ctgtggaagt accagatgaa gtacgctcca      180

aatgatccag actacttcaa cagagatcgt tttgtcttgt caaacggtca cgtctgtctg      240

ttccaatact tgttccagca cttaactggt ttgaaggaga tgactgtcaa gcaacttcaa      300

tcttaccact cttccgatta tcactcattg actcctggac accctgaaat tgagaaccct      360

gctgttgagg ttaccactgg tcccctggga caaggtatct ctaacgctgt cggtatggcc      420

attggttcaa agaacctggc cgctacttac aacagacctg gcttccctgt cgttgacaac      480

actatctatg ctattgttgg tgatgcttgt ttgcaagagg gacctgcttt ggaatcgatt      540

tccttagctg gtcacttggc cttggacaac cttattgtga tctacgacaa caaccaggtt      600

tgttgtgatg gttccgtcga tgttaacaac accgaagaca tttctgctaa gtttagagct      660

cagaactgga atgtcattga agtcgagaat ggttctagag atgttgctac ccttgtcaag      720

gccatcgaat gggccaaggc tgagaatgag agaccaactc tgatcaacgt tagaactgaa      780

attggacagg attctgcttt cggtaaccac cacgctgctc acggttctgc tcttggtgag      840

gaaggtatcc gggagttgaa ggccaagtac ggtttcgatg tcgctagaaa gttctggttc      900

ccacaggagg tctatgattt ctttgctgaa aaaccagccg agggtgatca actagttgct      960

aactggaaga aacttttgga tgagtacgtt aagaactatc ctcaagaagg tgaggaatta     1020

aaggcccgta ttagaggtga acttccaaag aactggaaga gtttcattcc acaggacaaa     1080

ccaaccgagc caactgctac cagaacctct gctagagaaa ttgttagatc tctgggacaa     1140

aaccttcctc aggttattgc tggttctggt gacttgtccg tgtccattct tttgaactgg     1200

ggaggagtta agtacttctt caaccctaag ttacaaactt tctgtggatt gggtggtgac     1260

tactctggta gatatattga gtttggtatc agagaacact ctatgtgtgc tattgccaat     1320

ggtttggctg catacaacaa gggtactttc ttgcctatta cctcaacttt ctacatgttc     1380

tacctgtatg cagcacctgc cttgcgtatg gctgcacttc aagagttgaa agcaattcac     1440

attgctacac acgactccat cggagctggt gaagatggtc caacgcacca gcctattgct     1500

ttgtcttcat tattcagagc tatgcccaac ttctactaca ttagaccagc cgatgctacc     1560

gaggttgcag ctctgtttga agtagctgtt gagctcgagc actccacctt gttctctctg     1620

tccagacacg aggttgagca atacccaggt aagacttcgg ctgagggagc caaaagaggt     1680

ggttacgtcg ttgaagactg tgagggtaag ccagacgtcc aattaattgg tgctggttcc     1740

gaattggagt ttgccgtcaa aactgctcgt ttgctaagac aacagaaggg atggaaggtc     1800

agagttctgt cattcccatg tcagagactg tttgaccaac aatccctggc atacagacgt     1860

tctgtcctta gaagaggaga ggttccaact gtcgttgttg aggcctatgt cgcatacgga     1920

tgggagagat acgccactgc tggttacacc atgaacacct ttggtaagtc tcttcctgtt     1980

gaggatgtct acaaatactt cggatacact cctgagaaga ttggtgagaa ggttgctgca     2040

tacgtcaact ctattaaggc tagtcctcaa atcctttacg aattcaccga tttgaaggga     2100

aaaccaaagc acgacaaact ataa                                            2124


<210>  3
<211>  2124
<212>  DNA
<213>  Pichia pastoris

<400>  3
atggctagaa ttcccaaagc agtttcttac aatgatgaca tccatgactt ggtcatcaaa       60

accttccgtt gttacgttct cgacttagtc gaacagtatg gtggtggtca ccctggttct      120

gccatgggta tggtcgccat tggtatcgct ctgtggaagt accagatgaa gtacgctcca      180

aatgatccag actacttcaa cagagatcgt tttgtcttgt caaacggtca cgtctgtttg      240

ttccaatact tgttccagca cttaactggt ttgaaggaga tgactgtcaa gcaacttcaa      300

tcttaccact cttccgatta tcactcattg actcctggac accctgaaat tgagaaccct      360

gctgttgagg ttaccactgg tcccctggga caaggtatct ctaacgctgt cggtatggcc      420

attggttcaa agaacctggc cgctacttac aacagacctg gcttccctgt cgttgacaac      480

actatctatg ctattgttgg tgatgcttgt ttgcaagagg gacctgcttt ggaatcgatt      540

tccttagccg gtcacttggc cttggacaac cttattgtga tctacgacaa caaccaggtt      600

tgttgtgatg gttccgtcga tgttaacaac accgaagaca tctccgcaaa gttcagagct      660

cagaactgga atgttatcga cattgtagac ggttctagag atgtcgctac cattgtcaag      720

gctatcgatt gggccaaggc tgagactgag agaccaactc tgatcaacgt tagaactgaa      780

attggacagg attctgcttt cggtaaccac cacgctgctc acggttctgc tctaggtgag      840

gaaggtatcc gggagttgaa gactaagtac ggttttaacc ctgcccaaaa gttctggttc      900

cctaaagaag tatacgactt ctttgctgag aaaccagcta aaggtgacga gttagtaaag      960

aactggaaaa agttagttga tagctatgtc aaagagtacc ctcgtgaggg acaagagttc     1020

ctttctcgtg ttagaggtga gcttccaaag aactggagaa cttacattcc tcaagacaag     1080

cctaccgaac caaccgccac cagaacctct gctagagaaa ttgttagggc ccttggaaag     1140

aaccttcctc aagttattgc cggttccggt gacttatctg tctcaattct tttgaactgg     1200

gacggagtga agtacttctt caaccctaag ttacagactt tctgtggatt aggtggtgac     1260

tactctggta gatatattga gtttggtatc agagaacact ctatgtgtgc tattgccaac     1320

ggtttggctg catacaacaa gggtactttc ttgcctatta cctctacctt ctacatgttc     1380

tacctgtatg cagcacctgc cttgcgtatg gctgctcttc aagagttgaa agcgattcac     1440

attgctacac acgactctat tggagctggt gaagatggtc caacccacca gcctattgct     1500

ttgtcttcat tattcagagc tatgcccaac ttctactaca tgagaccagc cgatgctacc     1560

gaagttgcag ctctgtttga agtggctgtt gagcttgaac actccacatt gctttctctg     1620

tccagacacg aggttgacca atacccaggt aagacttctg cccaaggagc caaaagaggt     1680

ggttacgttg ttgaagactg cgaaggaaag ccagatgtgc aactgatcgg aactggttcc     1740

gagttggaat tcgctattaa gactgctcgt ttgctaagac aacagaaggg atggaaggtc     1800

agagttctgt cattcccatg tcagagattg tttgacgagc agtctattac ttacagacgt     1860

tccgtcctta gaagaggaga agttccaact gtcgttgttg aggcctatgt cgcatacgga     1920

tgggagagat acgccactgc tggttacacc atgaacacct tcggtaagtc tcttcctgtt     1980

gaggatgtct acaaatactt cggatacact cctgagaaga ttggtgagag agtggttcaa     2040

tatgtcaact ctatcaaggc tagtcctcaa atcctttacg aattccacga cttgaaggga     2100

aaaccaaagc atgacaagtt gtaa                                            2124


<210>  4
<211>  707
<212>  PRT
<213>  Pichia pastoris

<400>  4

Met Ala Arg Ile Pro Lys Ala Val Ser Thr Gln Asp Asp Ile His Glu 
1               5                   10                  15      


Leu Val Ile Lys Thr Phe Arg Cys Tyr Val Leu Asp Leu Val Glu Gln 
            20                  25                  30          


Tyr Gly Gly Gly His Pro Gly Ser Ala Met Gly Met Val Ala Ile Gly 
        35                  40                  45              


Ile Ala Leu Trp Lys Tyr Gln Met Lys Tyr Ala Pro Asn Asp Pro Asp 
    50                  55                  60                  


Tyr Phe Asn Arg Asp Arg Phe Val Leu Ser Asn Gly His Val Cys Leu 
65                  70                  75                  80  


Phe Gln Tyr Leu Phe Gln His Leu Thr Gly Leu Lys Glu Met Thr Val 
                85                  90                  95      


Lys Gln Leu Gln Ser Tyr His Ser Ser Asp Tyr His Ser Leu Thr Pro 
            100                 105                 110         


Gly His Pro Glu Ile Glu Asn Pro Ala Val Glu Val Thr Thr Gly Pro 
        115                 120                 125             


Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met Ala Ile Gly Ser Lys 
    130                 135                 140                 


Asn Leu Ala Ala Thr Tyr Asn Arg Pro Gly Phe Pro Val Val Asp Asn 
145                 150                 155                 160 


Thr Ile Tyr Ala Ile Val Gly Asp Ala Cys Leu Gln Glu Gly Pro Ala 
                165                 170                 175     


Leu Glu Ser Ile Ser Leu Ala Gly His Leu Ala Leu Asp Asn Leu Ile 
            180                 185                 190         


Val Ile Tyr Asp Asn Asn Gln Val Cys Cys Asp Gly Ser Val Asp Val 
        195                 200                 205             


Asn Asn Thr Glu Asp Ile Ser Ala Lys Phe Arg Ala Gln Asn Trp Asn 
    210                 215                 220                 


Val Ile Glu Val Glu Asn Gly Ser Arg Asp Val Ala Thr Leu Val Lys 
225                 230                 235                 240 


Ala Ile Glu Trp Ala Lys Ala Glu Asn Glu Arg Pro Thr Leu Ile Asn 
                245                 250                 255     


Val Arg Thr Glu Ile Gly Gln Asp Ser Ala Phe Gly Asn His His Ala 
            260                 265                 270         


Ala His Gly Ser Ala Leu Gly Glu Glu Gly Ile Arg Glu Leu Lys Ala 
        275                 280                 285             


Lys Tyr Gly Phe Asp Val Ala Arg Lys Phe Trp Phe Pro Gln Glu Val 
    290                 295                 300                 


Tyr Asp Phe Phe Ala Glu Lys Pro Ala Glu Gly Asp Gln Leu Val Ala 
305                 310                 315                 320 


Asn Trp Lys Lys Leu Leu Asp Glu Tyr Val Lys Asn Tyr Pro Gln Glu 
                325                 330                 335     


Gly Glu Glu Leu Lys Ala Arg Ile Arg Gly Glu Leu Pro Lys Asn Trp 
            340                 345                 350         


Lys Ser Phe Ile Pro Gln Asp Lys Pro Thr Glu Pro Thr Ala Thr Arg 
        355                 360                 365             


Thr Ser Ala Arg Glu Ile Val Arg Ser Leu Gly Gln Asn Leu Pro Gln 
    370                 375                 380                 


Val Ile Ala Gly Ser Gly Asp Leu Ser Val Ser Ile Leu Leu Asn Trp 
385                 390                 395                 400 


Gly Gly Val Lys Tyr Phe Phe Asn Pro Lys Leu Gln Thr Phe Cys Gly 
                405                 410                 415     


Leu Gly Gly Asp Tyr Ser Gly Arg Tyr Ile Glu Phe Gly Ile Arg Glu 
            420                 425                 430         


His Ser Met Cys Ala Ile Ala Asn Gly Leu Ala Ala Tyr Asn Lys Gly 
        435                 440                 445             


Thr Phe Leu Pro Ile Thr Ser Thr Phe Tyr Met Phe Tyr Leu Tyr Ala 
    450                 455                 460                 


Ala Pro Ala Leu Arg Met Ala Ala Leu Gln Glu Leu Lys Ala Ile His 
465                 470                 475                 480 


Ile Ala Thr His Asp Ser Ile Gly Ala Gly Glu Asp Gly Pro Thr His 
                485                 490                 495     


Gln Pro Ile Ala Leu Ser Ser Leu Phe Arg Ala Met Pro Asn Phe Tyr 
            500                 505                 510         


Tyr Ile Arg Pro Ala Asp Ala Thr Glu Val Ala Ala Leu Phe Glu Val 
        515                 520                 525             


Ala Val Glu Leu Glu His Ser Thr Leu Phe Ser Leu Ser Arg His Glu 
    530                 535                 540                 


Val Glu Gln Tyr Pro Gly Lys Thr Ser Ala Glu Gly Ala Lys Arg Gly 
545                 550                 555                 560 


Gly Tyr Val Val Glu Asp Cys Glu Gly Lys Pro Asp Val Gln Leu Ile 
                565                 570                 575     


Gly Ala Gly Ser Glu Leu Glu Phe Ala Val Lys Thr Ala Arg Leu Leu 
            580                 585                 590         


Arg Gln Gln Lys Gly Trp Lys Val Arg Val Leu Ser Phe Pro Cys Gln 
        595                 600                 605             


Arg Leu Phe Asp Gln Gln Ser Leu Ala Tyr Arg Arg Ser Val Leu Arg 
    610                 615                 620                 


Arg Gly Glu Val Pro Thr Val Val Val Glu Ala Tyr Val Ala Tyr Gly 
625                 630                 635                 640 


Trp Glu Arg Tyr Ala Thr Ala Gly Tyr Thr Met Asn Thr Phe Gly Lys 
                645                 650                 655     


Ser Leu Pro Val Glu Asp Val Tyr Lys Tyr Phe Gly Tyr Thr Pro Glu 
            660                 665                 670         


Lys Ile Gly Glu Lys Val Ala Ala Tyr Val Asn Ser Ile Lys Ala Ser 
        675                 680                 685             


Pro Gln Ile Leu Tyr Glu Phe Thr Asp Leu Lys Gly Lys Pro Lys His 
    690                 695                 700                 


Asp Lys Leu 
705         


<210>  5
<211>  707
<212>  PRT
<213>  Pichia pastoris

<400>  5

Met Ala Arg Ile Pro Lys Ala Val Ser Tyr Asn Asp Asp Ile His Asp 
1               5                   10                  15      


Leu Val Ile Lys Thr Phe Arg Cys Tyr Val Leu Asp Leu Val Glu Gln 
            20                  25                  30          


Tyr Gly Gly Gly His Pro Gly Ser Ala Met Gly Met Val Ala Ile Gly 
        35                  40                  45              


Ile Ala Leu Trp Lys Tyr Gln Met Lys Tyr Ala Pro Asn Asp Pro Asp 
    50                  55                  60                  


Tyr Phe Asn Arg Asp Arg Phe Val Leu Ser Asn Gly His Val Cys Leu 
65                  70                  75                  80  


Phe Gln Tyr Leu Phe Gln His Leu Thr Gly Leu Lys Glu Met Thr Val 
                85                  90                  95      


Lys Gln Leu Gln Ser Tyr His Ser Ser Asp Tyr His Ser Leu Thr Pro 
            100                 105                 110         


Gly His Pro Glu Ile Glu Asn Pro Ala Val Glu Val Thr Thr Gly Pro 
        115                 120                 125             


Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met Ala Ile Gly Ser Lys 
    130                 135                 140                 


Asn Leu Ala Ala Thr Tyr Asn Arg Pro Gly Phe Pro Val Val Asp Asn 
145                 150                 155                 160 


Thr Ile Tyr Ala Ile Val Gly Asp Ala Cys Leu Gln Glu Gly Pro Ala 
                165                 170                 175     


Leu Glu Ser Ile Ser Leu Ala Gly His Leu Ala Leu Asp Asn Leu Ile 
            180                 185                 190         


Val Ile Tyr Asp Asn Asn Gln Val Cys Cys Asp Gly Ser Val Asp Val 
        195                 200                 205             


Asn Asn Thr Glu Asp Ile Ser Ala Lys Phe Arg Ala Gln Asn Trp Asn 
    210                 215                 220                 


Val Ile Asp Ile Val Asp Gly Ser Arg Asp Val Ala Thr Ile Val Lys 
225                 230                 235                 240 


Ala Ile Asp Trp Ala Lys Ala Glu Thr Glu Arg Pro Thr Leu Ile Asn 
                245                 250                 255     


Val Arg Thr Glu Ile Gly Gln Asp Ser Ala Phe Gly Asn His His Ala 
            260                 265                 270         


Ala His Gly Ser Ala Leu Gly Glu Glu Gly Ile Arg Glu Leu Lys Thr 
        275                 280                 285             


Lys Tyr Gly Phe Asn Pro Ala Gln Lys Phe Trp Phe Pro Lys Glu Val 
    290                 295                 300                 


Tyr Asp Phe Phe Ala Glu Lys Pro Ala Lys Gly Asp Glu Leu Val Lys 
305                 310                 315                 320 


Asn Trp Lys Lys Leu Val Asp Ser Tyr Val Lys Glu Tyr Pro Arg Glu 
                325                 330                 335     


Gly Gln Glu Phe Leu Ser Arg Val Arg Gly Glu Leu Pro Lys Asn Trp 
            340                 345                 350         


Arg Thr Tyr Ile Pro Gln Asp Lys Pro Thr Glu Pro Thr Ala Thr Arg 
        355                 360                 365             


Thr Ser Ala Arg Glu Ile Val Arg Ala Leu Gly Lys Asn Leu Pro Gln 
    370                 375                 380                 


Val Ile Ala Gly Ser Gly Asp Leu Ser Val Ser Ile Leu Leu Asn Trp 
385                 390                 395                 400 


Asp Gly Val Lys Tyr Phe Phe Asn Pro Lys Leu Gln Thr Phe Cys Gly 
                405                 410                 415     


Leu Gly Gly Asp Tyr Ser Gly Arg Tyr Ile Glu Phe Gly Ile Arg Glu 
            420                 425                 430         


His Ser Met Cys Ala Ile Ala Asn Gly Leu Ala Ala Tyr Asn Lys Gly 
        435                 440                 445             


Thr Phe Leu Pro Ile Thr Ser Thr Phe Tyr Met Phe Tyr Leu Tyr Ala 
    450                 455                 460                 


Ala Pro Ala Leu Arg Met Ala Ala Leu Gln Glu Leu Lys Ala Ile His 
465                 470                 475                 480 


Ile Ala Thr His Asp Ser Ile Gly Ala Gly Glu Asp Gly Pro Thr His 
                485                 490                 495     


Gln Pro Ile Ala Leu Ser Ser Leu Phe Arg Ala Met Pro Asn Phe Tyr 
            500                 505                 510         


Tyr Met Arg Pro Ala Asp Ala Thr Glu Val Ala Ala Leu Phe Glu Val 
        515                 520                 525             


Ala Val Glu Leu Glu His Ser Thr Leu Leu Ser Leu Ser Arg His Glu 
    530                 535                 540                 


Val Asp Gln Tyr Pro Gly Lys Thr Ser Ala Gln Gly Ala Lys Arg Gly 
545                 550                 555                 560 


Gly Tyr Val Val Glu Asp Cys Glu Gly Lys Pro Asp Val Gln Leu Ile 
                565                 570                 575     


Gly Thr Gly Ser Glu Leu Glu Phe Ala Ile Lys Thr Ala Arg Leu Leu 
            580                 585                 590         


Arg Gln Gln Lys Gly Trp Lys Val Arg Val Leu Ser Phe Pro Cys Gln 
        595                 600                 605             


Arg Leu Phe Asp Glu Gln Ser Ile Thr Tyr Arg Arg Ser Val Leu Arg 
    610                 615                 620                 


Arg Gly Glu Val Pro Thr Val Val Val Glu Ala Tyr Val Ala Tyr Gly 
625                 630                 635                 640 


Trp Glu Arg Tyr Ala Thr Ala Gly Tyr Thr Met Asn Thr Phe Gly Lys 
                645                 650                 655     


Ser Leu Pro Val Glu Asp Val Tyr Lys Tyr Phe Gly Tyr Thr Pro Glu 
            660                 665                 670         


Lys Ile Gly Glu Arg Val Val Gln Tyr Val Asn Ser Ile Lys Ala Ser 
        675                 680                 685             


Pro Gln Ile Leu Tyr Glu Phe His Asp Leu Lys Gly Lys Pro Lys His 
    690                 695                 700                 


Asp Lys Leu 
705         


<210>  6
<211>  379
<212>  PRT
<213>  Pichia pastoris

<400>  6

Met Ser Thr Glu Gly Gln Ile Ile Lys Cys Lys Ala Ala Val Ala Trp 
1               5                   10                  15      


Glu Ala Gly Lys Asp Leu Ser Ile Glu Glu Ile Glu Val Leu Pro Pro 
            20                  25                  30          


Arg Ala His Glu Val Arg Val Lys Val Glu Phe Thr Gly Val Cys His 
        35                  40                  45              


Thr Asp Ala Tyr Thr Leu Ser Gly Ala Asp Ala Glu Gly Ser Phe Pro 
    50                  55                  60                  


Val Val Phe Gly His Glu Gly Ala Gly Val Val Glu Ser Val Gly Glu 
65                  70                  75                  80  


Gly Val Glu Ser Val Lys Val Gly Asp Ser Val Val Leu Leu Tyr Thr 
                85                  90                  95      


Pro Glu Cys Arg Glu Cys Lys Phe Cys Leu Ser Gly Lys Thr Asn Leu 
            100                 105                 110         


Cys Gly Lys Ile Arg Ala Thr Gln Gly Lys Gly Leu Leu Pro Asp Gly 
        115                 120                 125             


Thr Ser Arg Phe Arg Cys Lys Gly Lys Asp Leu Phe His Tyr Met Gly 
    130                 135                 140                 


Cys Ser Ser Phe Ser Gln Tyr Thr Val Val Ala Asp Ile Ser Val Val 
145                 150                 155                 160 


Lys Val Gln Asp Glu Ala Pro Lys Asp Lys Thr Cys Leu Leu Gly Cys 
                165                 170                 175     


Gly Val Thr Thr Gly Tyr Gly Ala Ala Ile Asn Thr Ala Lys Ile Ser 
            180                 185                 190         


Lys Gly Asp Lys Ile Gly Val Phe Gly Ala Gly Cys Ile Gly Leu Ser 
        195                 200                 205             


Val Ile Gln Gly Ala Val Ser Lys Gly Ala Ser Glu Ile Ile Val Ile 
    210                 215                 220                 


Asp Ile Asn Asp Ser Lys Lys Ala Trp Ala Asp Gln Phe Gly Ala Thr 
225                 230                 235                 240 


Lys Phe Val Asn Pro Thr Thr Leu Pro Glu Gly Thr Asn Ile Val Asp 
                245                 250                 255     


Tyr Leu Ile Asp Ile Thr Asp Gly Gly Phe Asp Tyr Thr Phe Asp Cys 
            260                 265                 270         


Thr Gly Asn Val Gln Val Met Arg Asn Ala Leu Glu Ser Cys His Lys 
        275                 280                 285             


Gly Trp Gly Glu Ser Ile Ile Ile Gly Val Ala Ala Ala Gly Lys Glu 
    290                 295                 300                 


Ile Ser Thr Arg Pro Phe Gln Leu Val Thr Gly Arg Val Trp Arg Gly 
305                 310                 315                 320 


Cys Ala Phe Gly Gly Ile Lys Gly Arg Thr Gln Met Pro Ser Leu Val 
                325                 330                 335     


Gln Asp Tyr Leu Asp Gly Lys Ile Lys Val Asp Glu Phe Ile Thr His 
            340                 345                 350         


Arg His Asp Leu Asp Asn Ile Asn Lys Ala Phe His Asp Met His Ala 
        355                 360                 365             


Gly Asn Cys Ile Arg Ala Val Ile Thr Met His 
    370                 375                 


<210>  7
<211>  1254
<212>  DNA
<213>  Pichia pastoris

<400>  7
atgtctaccg aaggtcaagt aagttcaatc aaagtaattg tttgggaggg aagaagattg       60

ttttattgcg aacctttcaa tatcttaccc gactaaataa ccattacagt gaatttttta      120

ctaactatat agatcatcaa atgtaaggca gctgttgcct gggaggcagg aaaggatctc      180

tctattgagg agattgaggt tcttcctcca agagcccatg aagttagagt gaaagtggaa      240

ttcactggtg tatgccacac tgatgcttac acgctttctg gtgcagatgc agagggaagt      300

ttccctgttg tgttcggcca tgaaggtgct ggtgttgtcg agtcagttgg agaaggtgtt      360

gagtccgtga aggttgggga ttctgtagtg cttctgtaca ctcctgagtg cagagagtgc      420

aagttctgtc tgtctggtaa gacgaacctc tgtggtaaaa tcagagccac ccagggtaaa      480

ggtttgttac cagacgggac ttctcgtttc cgttgtaagg gcaaggattt gtttcactat      540

atgggatgtt cttccttttc tcaatacact gtggtggctg acatctcagt ggttaaagtc      600

caagacgaag ctcctaagga caagacatgt ctgttgggtt gtggtgttac cacagggtac      660

ggtgctgcta tcaacactgc taagatctct aagggtgaca agatcggtgt gtttggtgct      720

ggatgtattg gattatctgt catccaaggt gcagtttcca aaggtgcaag cgagattatt      780

gtaattgaca tcaatgattc aaagaaggca tgggcggacc aatttggtgc aactaagttt      840

gtcaatccta caaccttacc agaaggtacc aatattgttg actacttgat tgatatcact      900

gacggaggct ttgactatac cttcgactgt accggtaatg ttcaagtaat gagaaatgca      960

cttgaatctt gccacaaggg ttggggtgag tcgatcatca tcggtgtcgc tgctgctggt     1020

aaagaaatct ctacccgtcc tttccagttg gttactggca gagtctggag aggatgcgcc     1080

tttggaggta tcaagggacg tactcaaatg ccatctttgg ttcaggacta tcttgatggt     1140

aagattaaag ttgacgagtt tatcacacac agacatgacc tggacaacat caacaaagca     1200

tttcatgaca tgcatgctgg aaactgtatt cgtgctgtga ttactatgca ctaa           1254


<210>  8
<211>  299
<212>  PRT
<213>  Pichia pastoris

<400>  8

Met Ser Ser Ile Thr Thr Ser Ile Phe Lys Val Thr Ala Glu Ile Gln 
1               5                   10                  15      


Ser Phe Gly Gly Lys Leu Val Lys Leu Gln His Lys Ser Asp Glu Thr 
            20                  25                  30          


Lys Thr Asp Met Asp Val Asn Val Tyr Leu Pro Ala Gln Phe Phe Ala 
        35                  40                  45              


Asn Gly Ala Lys Gly Lys Ser Leu Pro Val Leu Leu Tyr Leu Ser Gly 
    50                  55                  60                  


Leu Thr Cys Thr Pro Asn Asn Ala Ser Glu Lys Ala Phe Trp Gln Pro 
65                  70                  75                  80  


Tyr Ala Asn Lys Tyr Gly Phe Ala Val Val Phe Pro Asp Thr Ser Pro 
                85                  90                  95      


Arg Gly Leu Asn Ile Glu Gly Glu His Asp Ser Tyr Asp Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Phe Tyr Val Asp Ala Thr Thr Glu Lys Trp Lys Asp Asn 
        115                 120                 125             


Tyr Arg Met Tyr Ser Tyr Val Asn Ser Glu Leu Leu Pro Lys Leu Gln 
    130                 135                 140                 


Ala Asp Phe Pro Ile Leu Asn Phe Asp Asn Ile Ser Ile Thr Gly His 
145                 150                 155                 160 


Ser Met Gly Gly Tyr Gly Ala Leu Gln Leu Phe Leu Arg Asn Pro Gly 
                165                 170                 175     


Lys Phe Lys Ser Val Ser Ala Phe Ser Pro Ile Ser Asn Pro Thr Lys 
            180                 185                 190         


Ala Pro Trp Gly Glu Lys Cys Phe Ser Gly Tyr Leu Gly Gln Asp Lys 
        195                 200                 205             


Ser Thr Trp Thr Gln Tyr Asp Pro Thr Glu Leu Ile Gly Lys Tyr Gln 
    210                 215                 220                 


Gly Pro Ser Asp Ser Ser Ile Leu Ile His Val Gly Lys Ser Asp Ser 
225                 230                 235                 240 


Phe Tyr Phe Lys Asp His Gln Leu Leu Pro Glu Asn Phe Leu Lys Ala 
                245                 250                 255     


Ser Glu Asn Ser Val Phe Lys Gly Lys Val Asp Leu Asn Leu Val Asp 
            260                 265                 270         


Gly Tyr Asp His Ser Tyr Tyr Phe Ile Ser Ser Phe Thr Asp Val His 
        275                 280                 285             


Ala Ala His His Ala Lys Tyr Leu Gly Leu Asn 
    290                 295                 


<210>  9
<211>  900
<212>  DNA
<213>  Pichia pastoris

<400>  9
atgtcatcaa ttactacttc aatcttcaag gtaacagctg aaatccaaag ttttggggga       60

aagctagtca aacttcaaca caagtccgat gagacgaaga ctgacatgga tgtgaacgtc      120

taccttccag ctcaattctt tgccaatgga gccaagggaa aatcattacc agttctactt      180

tatttgagtg gtctgacttg cactcccaac aatgcctcag agaaggcatt ttggcaacca      240

tatgcaaata agtacggttt tgctgtggtt ttcccggata cttcacccag agggctcaac      300

atcgaaggag agcacgactc ttatgatttt ggatccggtg ccgggttcta cgtggatgcc      360

actactgaga aatggaagga taattataga atgtacagtt atgttaactc ggaattgcta      420

cccaaattgc aggctgactt cccaattcta aactttgaca atatttcaat cacgggccac      480

tccatgggag gttacggagc tttacagtta ttcttgagaa acccgggaaa attcaagtcg      540

gtttccgcat tttctccaat ctccaacccc actaaagccc catggggtga gaagtgcttc      600

tctggatacc tgggacagga caagtccact tggactcagt acgacccaac cgaattgatt      660

ggaaaatacc aaggcccctc agattccagc attttgattc acgttggaaa gagtgattcg      720

ttctacttca aggaccacca gctgctacct gagaacttct tgaaggcttc agagaactct      780

gtgttcaagg gaaaagtgga cttgaacttg gtagatggct atgaccattc ttactacttt      840

atctcttcat tcacagacgt tcatgctgct caccatgcaa agtatttggg gttaaactag      900


<210>  10
<211>  365
<212>  PRT
<213>  Pichia pastoris

<400>  10

Met Lys Ile Val Leu Val Leu Tyr Ser Ala Gly Lys His Ala Ala Asp 
1               5                   10                  15      


Glu Pro Lys Leu Tyr Gly Cys Ile Glu Asn Glu Leu Gly Ile Arg Gln 
            20                  25                  30          


Trp Leu Glu Lys Gly Gly His Glu Leu Val Thr Thr Ser Asp Lys Glu 
        35                  40                  45              


Gly Glu Asn Ser Glu Leu Glu Lys His Ile Pro Asp Ala Asp Val Ile 
    50                  55                  60                  


Ile Ser Thr Pro Phe His Pro Ala Tyr Ile Thr Lys Glu Arg Ile Gln 
65                  70                  75                  80  


Lys Ala Lys Lys Leu Lys Leu Leu Val Val Ala Gly Val Gly Ser Asp 
                85                  90                  95      


His Ile Asp Leu Asp Tyr Ile Glu Gln Asn Gly Leu Asp Ile Ser Val 
            100                 105                 110         


Leu Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His Val Val 
        115                 120                 125             


Met Thr Ile Leu Asn Leu Val Arg Asn Phe Val Pro Ala His Glu Gln 
    130                 135                 140                 


Ile Val Asn His Gly Trp Asp Val Ala Ala Ile Ala Lys Asp Ala Tyr 
145                 150                 155                 160 


Asp Ile Glu Gly Lys Thr Ile Ala Thr Ile Gly Ala Gly Arg Ile Gly 
                165                 170                 175     


Tyr Arg Val Leu Glu Arg Leu Val Ala Phe Asn Pro Lys Glu Leu Leu 
            180                 185                 190         


Tyr Tyr Asp Tyr Gln Gly Leu Pro Lys Glu Ala Glu Glu Lys Val Gly 
        195                 200                 205             


Ala Arg Arg Val Asp Thr Val Glu Glu Leu Val Ala Gln Ala Asp Val 
    210                 215                 220                 


Val Thr Val Asn Ala Pro Leu His Ala Gly Thr Lys Gly Leu Val Asn 
225                 230                 235                 240 


Lys Glu Leu Leu Ser Lys Phe Lys Lys Gly Ala Trp Leu Val Asn Thr 
                245                 250                 255     


Ala Arg Gly Ala Ile Cys Asn Ala Gln Asp Val Ala Asp Ala Val Ala 
            260                 265                 270         


Ser Gly Gln Leu Arg Gly Tyr Gly Gly Asp Val Trp Phe Pro Gln Pro 
        275                 280                 285             


Ala Pro Lys Asp His Pro Trp Arg Asp Met Arg Asn Lys Tyr Gly Tyr 
    290                 295                 300                 


Gly Asn Ala Met Thr Pro His Tyr Ser Gly Thr Thr Leu Asp Ala Gln 
305                 310                 315                 320 


Val Arg Tyr Ala Glu Gly Thr Lys Asn Ile Leu Asn Ser Phe Leu Thr 
                325                 330                 335     


Lys Lys Phe Asp Tyr Arg Pro Gln Asp Val Ile Leu Leu Asn Gly Lys 
            340                 345                 350         


Tyr Lys Thr Lys Ala Tyr Gly Asn Asp Lys Lys Val Ala 
        355                 360                 365 


<210>  11
<211>  1098
<212>  DNA
<213>  Pichia pastoris

<400>  11
atgaaaatcg ttctcgtttt gtactccgct ggtaagcacg ccgccgatga accaaagttg       60

tatggttgta tcgaaaatga attgggtatt agacaatggc ttgagaaggg cggccatgaa      120

ttggttacta catcagacaa agagggtgaa aactctgagt tagaaaagca cattcctgac      180

gctgatgtga ttatttccac tccattccat ccagcctaca tcacgaagga gagaatccaa      240

aaagccaaga agctgaagtt gttggtcgtt gctggtgtcg gttccgacca cattgacttg      300

gactacattg aacaaaatgg cctagatatt tcggtcctag aggttactgg ttccaacgtt      360

gtttcagtgg ctgagcatgt cgttatgact atattgaact tggtgagaaa ctttgttcca      420

gctcacgagc aaattgttaa ccacggctgg gacgttgctg ccatcgccaa ggacgcctac      480

gatatcgaag gtaagaccat cgcaacaatt ggtgctggaa gaattggtta cagagtctta      540

gagagacttg tggctttcaa ccctaaggaa ttgttgtact acgactacca aggtcttcca      600

aaagaggccg aggaaaaagt tggtgccaga agagtcgaca ctgtcgagga gctggttgct      660

caagccgatg ttgttaccgt caatgcccca ctgcacgcag gtactaaggg tttagttaac      720

aaggagcttc tgtccaagtt caagaagggt gcttggttgg ttaacacagc cagaggtgcc      780

atctgcaatg ctcaagatgt cgctgatgcc gttgcatctg gtcaattgag aggttacggt      840

ggtgacgtct ggttccctca gccagctcca aaggaccatc catggagaga tatgagaaac      900

aagtacggat acggaaacgc catgactcct cattactcag gtaccacttt ggacgcccag      960

gtcagatatg ccgaaggtac caagaacatc ttgaactcat tccttaccaa gaagtttgac     1020

tacagacctc aagatgtcat tcttttgaac ggtaagtaca agaccaaggc ttatggtaat     1080

gacaaaaagg tcgcataa                                                   1098


<210>  12
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
gagctcggcc agcttggccg ttgtttcatg aaagggttac ggg                         43


<210>  13
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gtttaaactt ttgatgtttg atagtttgat aagagtg                                37


<210>  14
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
actagtgtag atttggccac taacgggtta gtag                                   34


<210>  15
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gtcgacggcc gatggggccg atgtaagacg tgacgatgat tgg                         43


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
ccgggcgttg ccatttctga gtgc                                              24


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
gtttgaccaa caatccctgg ca                                                22


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
gaattcatgt ctaccgaagg tcaagtaagt                                        30


<210>  19
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
ggccggcctt agtgcatagt aatcacagca cg                                     32


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
gaattcatgt catcaattac tacttcaatc                                        30


<210>  21
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
ggccggccct agtttaaccc caaatacttt gc                                     32


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gaattcatga aaatcgttct cgttttgtac                                        30


<210>  23
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
ggccggcctt atgcgacctt tttgtcatta cc                                     32


