                         SEQUENCE LISTING

<110>  LaRoque Jameson, Katherine
       Khavari, Paul A.
 
<120>  IQGAP Inhibitors and Uses Thereof in Cancer

<130>  STAN-811WO

<150>  61/494,774
<151>  2011-06-08

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


Tyr Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu Pro Pro 
            20                  25                  30          


<210>  2
<211>  32
<212>  PRT
<213>  Chimp

<400>  2

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


Tyr Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu Pro Pro 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Rhesus

<400>  3

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


Tyr Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu Pro Pro 
            20                  25                  30          


<210>  4
<211>  32
<212>  PRT
<213>  Mouse

<400>  4

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


His Tyr His Asn Leu Glu Thr Gln Ala Gly Gly Trp Ala Glu Pro Pro 
            20                  25                  30          


<210>  5
<211>  32
<212>  PRT
<213>  Rat

<400>  5

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


His Tyr His Asn Leu Glu Thr Gln Ala Gly Gly Trp Ala Glu Pro Pro 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Cow

<400>  6

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


His Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu Pro Ser 
            20                  25                  30          


<210>  7
<211>  32
<212>  PRT
<213>  Opossum

<400>  7

Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly Tyr Tyr 
1               5                   10                  15      


His Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu Pro Ser 
            20                  25                  30          


<210>  8
<211>  32
<212>  PRT
<213>  Zebra Finch

<400>  8

Gly Asn Gly Ser Asp Trp Val Lys His Trp Val Arg Gly Gly Tyr Tyr 
1               5                   10                  15      


His Tyr His Asn Leu Arg Thr Lys Asp Gly Gly Trp Asp Glu Pro Ala 
            20                  25                  30          


<210>  9
<211>  32
<212>  PRT
<213>  Xenopus

<400>  9

Asp Asn Gly Ser Glu Trp Val Gln His Trp Val Lys Gly Gly Tyr Leu 
1               5                   10                  15      


Tyr Tyr Phe Asn Leu Ser Thr Asn Glu Gly Arg Trp Val Glu Pro Gln 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Zebra fish

<400>  10

Asp Asn Gly Ser Glu Trp Met Glu His Trp Val Lys Gly Gly His Asn 
1               5                   10                  15      


Tyr Tyr Tyr Asn Leu Lys Thr Gly Gln Gly Thr Trp Asp Lys Pro Ala 
            20                  25                  30          


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  11
gaacguggcu uaugaguacu u                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  12
guacucauaa gccacguucu u                                                 21


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  13
ccucucgcuc ugaugggaca uuugu                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  14
acaaaugucc caucagagcg agagg                                             25


<210>  15
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  15
cagccaucau gacauuuacc augaa                                             25


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  16
uucaugguaa augucaugau ggcug                                             25


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  17
gauuagaugu caauacagau u                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  18
ucuguauuga caucuaaucu u                                                 21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  19
agaaagaggu gaugaacuau u                                                 21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  20
uaguucauca ccucuuucuu u                                                 21


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  21
ugaacacggu gcaguuuaau u                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  22
uuaaacugca ccguguucau u                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  23
gaacugcccu ucacccuaau u                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  24
uuagggugaa gggcaguucu u                                                 21


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  25
cggcguagac uuugagauuu u                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  26
aaucucaaag ucuacgcggu u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  27
cggaugaccu aaagcgauuu u                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  28
aaucguuuua ggucauccgu u                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  29
gaccggaugu uaaccuuuau u                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  30
uaaagguuaa cauccggucu u                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  31
guacagggcu ccagaaauuu u                                                 21


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Ribonucleotide

<400>  32
aauuucugga gcccuguacu u                                                 21


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  33
ttcgccacta cccagacctt gttt                                              24


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  34
cctgtcttgg atgtggcctt tgg                                               23


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  35
ttcaacctca ggacagacct ccat                                              24


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  36
actggcctcg ttcatagctg ttca                                              24


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  37
agcaagtccc atgagtctca                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  38
caacctgcaa tgcttgcact                                                   20


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  39
cagaccgatt taaggctgca agca                                              24


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  40
tccacattaa atcgtacggc tcgc                                              24


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  41
aggcatgaag gatgacaagg agga                                              24


<210>  42
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  42
aatcctgagg ccagaggttc atca                                              24


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  43
ggagaggtga gggcaggatt aaga                                              24


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  44
gtatgaacac agcttgccac cca                                               23


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  45
gcatgctttg cgacctggtt tctt                                              24


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  46
tagtcctgta ttggcactgc tgct                                              24


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  47
gaagagagag accctcactg ctg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  48
actgtgagga ggggagattc agt                                               23


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  49
tgaccctgaa gttcatctgc a                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  50
tcttgtagtt gccgtcgtcc t                                                 21


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  51
ttgcagtctg tggcatgtg                                                    19


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  52
cctgctgaca ggtcaatgat                                                   20


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  53
ttgcagtctg tggcatgtg                                                    19


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  54
cctgctcttt actgaaggct                                                   20


<210>  55
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  55
caccaccagc tccacttcag cacatt                                            26


<210>  56
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  56
cgcaccaacg tgtagaaggc atcctc                                            26


<210>  57
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  57
gctcgcggat ccaccatgga acaaaaactt atttctgaag aagatctgga taataacagc       60

aagtgggtga agcac                                                        75


<210>  58
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  58
ataagtgcgg ccgcttatgg gggttcatcc catcctcctt cctg                        44


<210>  59
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  59
ggtgaagcac tgggtaaaag gtggatatta tgctgcccac aatctggaga cc               52


<210>  60
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oglionucleotide

<400>  60
ggtctccaga ttgtgggcag cataatatcc accttttacc cagtgcttca cc               52


<210>  61
<211>  7219
<212>  DNA
<213>  Homo sapiens

<400>  61
ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa       60

ggtttcacgg cttcctcagc agagactcgg gctcgtccgc catgtccgcc gcagacgagg      120

ttgacgggct gggcgtggcc cggccgcact atggctctgt cctggataat gaaagactta      180

ctgcagagga gatggatgaa aggagacgtc agaacgtggc ttatgagtac ctttgtcatt      240

tggaagaagc gaagaggtgg atggaagcat gcctagggga agatctgcct cccaccacag      300

aactggagga ggggcttagg aatggggtct accttgccaa actggggaac ttcttctctc      360

ccaaagtagt gtccctgaaa aaaatctatg atcgagaaca gaccagatac aaggcgactg      420

gcctccactt tagacacact gataatgtga ttcagtggtt gaatgccatg gatgagattg      480

gattgcctaa gattttttac ccagaaacta cagatatcta tgatcgaaag aacatgccaa      540

gatgtatcta ctgtatccat gcactcagtt tgtacctgtt caagctaggc ctggcccctc      600

agattcaaga cctatatgga aaggttgact tcacagaaga agaaatcaac aacatgaaga      660

ctgagttgga gaagtatggc atccagatgc ctgcctttag caagattggg ggcatcttgg      720

ctaatgaact gtcagtggat gaagccgcat tacatgctgc tgttattgct attaatgaag      780

ctattgaccg tagaattcca gccgacacat ttgcagcttt gaaaaatccg aatgccatgc      840

ttgtaaatct tgaagagccc ttggcatcca cttaccagga tatactttac caggctaagc      900

aggacaaaat gacaaatgct aaaaacagga cagaaaactc agagagagaa agagatgttt      960

atgaggagct gctcacgcaa gctgaaattc aaggcaatat aaacaaagtc aatacatttt     1020

ctgcattagc aaatatcgac ctggctttag aacaaggaga tgcactggcc ttgttcaggg     1080

ctctgcagtc accagccctg gggcttcgag gactgcagca acagaatagc gactggtact     1140

tgaagcagct cctgagtgat aaacagcaga agagacagag tggtcagact gaccccctgc     1200

agaaggagga gctgcagtct ggagtggatg ctgcaaacag tgctgcccag caatatcaga     1260

gaagattggc agcagtagca ctgattaatg ctgcaatcca gaagggtgtt gctgagaaga     1320

ctgttttgga actgatgaat cccgaagccc agctgcccca ggtgtatcca tttgccgccg     1380

atctctatca gaaggagctg gctaccctgc agcgacaaag tcctgaacat aatctcaccc     1440

acccagagct ctctgtcgca gtggagatgt tgtcatcggt ggccctgatc aacagggcat     1500

tggaatcagg agatgtgaat acagtgtgga agcaattgag cagttcagtt actggtctta     1560

ccaatattga ggaagaaaac tgtcagaggt atctcgatga gttgatgaaa ctgaaggctc     1620

aggcacatgc agagaataat gaattcatta catggaatga tatccaagct tgcgtggacc     1680

atgtgaacct ggtggtgcaa gaggaacatg agaggatttt agccattggt ttaattaatg     1740

aagccctgga tgaaggtgat gcccaaaaga ctctgcaggc cctacagatt cctgcagcta     1800

aacttgaggg agtccttgca gaagtggccc agcattacca agacacgctg attagagcga     1860

agagagagaa agcccaggaa atccaggatg agtcagctgt gttatggttg gatgaaattc     1920

aaggtggaat ctggcagtcc aacaaagaca cccaagaagc acagaagttt gccttaggaa     1980

tctttgccat taatgaggca gtagaaagtg gtgatgttgg caaaacactg agtgcccttc     2040

gctcccctga tgttggcttg tatggagtca tccctgagtg tggtgaaact taccacagtg     2100

atcttgctga agccaagaag aaaaaactgg cagtaggaga taataacagc aagtgggtga     2160

agcactgggt aaaaggtgga tattattatt accacaatct ggagacccag gaaggaggat     2220

gggatgaacc tccaaatttt gtgcaaaatt ctatgcagct ttctcgggag gagatccaga     2280

gttctatctc tggggtgact gccgcatata accgagaaca gctgtggctg gccaatgaag     2340

gcctgatcac caggctgcag gctcgctgcc gtggatactt agttcgacag gaattccgat     2400

ccaggatgaa tttcctgaag aaacaaatcc ctgccatcac ctgcattcag tcacagtgga     2460

gaggatacaa gcagaagaag gcatatcaag atcggttagc ttacctgcgc tcccacaaag     2520

atgaagttgt aaagattcag tccctggcaa ggatgcacca agctcgaaag cgctatcgag     2580

atcgcctgca gtacttccgg gaccatataa atgacattat caaaatccag gcttttattc     2640

gggcaaacaa agctcgggat gactacaaga ctctcatcaa tgctgaggat cctcctatgg     2700

ttgtggtccg aaaatttgtc cacctgctgg accaaagtga ccaggatttt caggaggagc     2760

ttgaccttat gaagatgcgg gaagaggtta tcaccctcat tcgttctaac cagcagctgg     2820

agaatgacct caatctcatg gatatcaaaa ttggactgct agtgaaaaat aagattacgt     2880

tgcaggatgt ggtttcccac agtaaaaaac ttaccaaaaa aaataaggaa cagttgtctg     2940

atatgatgat gataaataaa cagaagggag gtctcaaggc tttgagcaag gagaagagag     3000

agaagttgga agcttaccag cacctgtttt atttattgca aaccaatccc acctatctgg     3060

ccaagctcat ttttcagatg ccccagaaca agtccaccaa gttcatggac tctgtaatct     3120

tcacactcta caactacgcg tccaaccagc gagaggagta cctgctcctg cggctcttta     3180

agacagcact ccaagaggaa atcaagtcga aggtagatca gattcaagag attgtgacag     3240

gaaatcctac ggttattaaa atggttgtaa gtttcaaccg tggtgcccgt ggccagaatg     3300

ccctgagaca gatcttggcc ccagtcgtga aggaaattat ggatgacaaa tctctcaaca     3360

tcaaaactga ccctgtggat atttacaaat cttgggttaa tcagatggag tctcagacag     3420

gagaggcaag caaactgccc tatgatgtga cccctgagca ggcgctagct catgaagaag     3480

tgaagacacg gctagacagc tccatcagga acatgcgggc tgtgacagac aagtttctct     3540

cagccattgt cagctctgtg gacaaaatcc cttatgggat gcgcttcatt gccaaagtgc     3600

tgaaggactc gttgcatgag aagttccctg atgctggtga ggatgagctg ctgaagatta     3660

ttggtaactt gctttattat cgatacatga atccagccat tgttgctcct gatgcctttg     3720

acatcattga cctgtcagca ggaggccagc ttaccacaga ccaacgccga aatctgggct     3780

ccattgcaaa aatgcttcag catgctgctt ccaataagat gtttctggga gataatgccc     3840

acttaagcat cattaatgaa tatctttccc agtcctacca gaaattcaga cggtttttcc     3900

aaactgcttg tgatgtccca gagcttcagg ataaatttaa tgtggatgag tactctgatt     3960

tagtaaccct caccaaacca gtaatctaca tttccattgg tgaaatcatc aacacccaca     4020

ctctcctgtt ggatcaccag gatgccattg ctccggagca caatgatcca atccacgaac     4080

tgctggacga cctcggcgag gtgcccacca tcgagtccct gataggggaa agctctggca     4140

atttaaatga cccaaataag gaggcactgg ctaagacgga agtgtctctc accctgacca     4200

acaagttcga cgtgcctgga gatgagaatg cagaaatgga tgctcgaacc atcttactga     4260

atacaaaacg tttaattgtg gatgtcatcc ggttccagcc aggagagacc ttgactgaaa     4320

tcctagaaac accagccacc agtgaacagg aagcagaaca tcagagagcc atgcagagac     4380

gtgctatccg tgatgccaaa acacctgaca agatgaaaaa gtcaaaatct gtaaaggaag     4440

acagcaacct cactcttcaa gagaagaaag agaagatcca gacaggttta aagaagctaa     4500

cagagcttgg aaccgtggac ccaaagaaca aataccagga actgatcaac gacattgcca     4560

gggatattcg gaatcagcgg aggtaccgac agaggagaaa ggccgaacta gtgaaactgc     4620

aacagacata cgctgctctg aactctaagg ccacctttta tggggagcag gtggattact     4680

ataaaagcta tatcaaaacc tgcttggata acttagccag caagggcaaa gtctccaaaa     4740

agcctaggga aatgaaagga aagaaaagca aaaagatttc tctgaaatat acagcagcaa     4800

gactacatga aaaaggagtt cttctggaaa ttgaggacct gcaagtgaat cagtttaaaa     4860

atgttatatt tgaaatcagt ccaacagaag aagttggaga cttcgaagtg aaagccaaat     4920

tcatgggagt tcaaatggag acttttatgt tacattatca ggacctgctg cagctacagt     4980

atgaaggagt tgcagtcatg aaattatttg atagagctaa agtaaatgtc aacctcctga     5040

tcttccttct caacaaaaag ttctacggga agtaattgat cgtttgctgc cagcccagaa     5100

ggatgaagga aagaagcacc tcacagctcc tttctaggtc cttctttcct cattggaagc     5160

aaagacctag ccaacaacag cacctcaatc tgatacactc ccgatgccac atttttaact     5220

cctctcgctc tgatgggaca tttgttaccc ttttttcata gtgaaattgt gtttcaggct     5280

tagtctgacc tttctggttt cttcattttc ttccattact taggaaagag tggaaactcc     5340

actaaaattt ctctgtgttg ttacagtctt agaggttgca gtactatatt gtaagctttg     5400

gtgtttgttt aattagcaat agggatggta ggattcaaat gtgtgtcatt tagaagtgga     5460

agctattagc accaatgaca taaatacata caagacacac aactaaaatg tcatgttatt     5520

aacagttatt aggttgtcat ttaaaaataa agttccttta tatttctgtc ccatcaggaa     5580

aactgaagga tatggggaat cattggttat cttccattgt gtttttcttt atggacagga     5640

gctaatggaa gtgacagtca tgttcaaagg aagcatttct agaaaaaagg agataatgtt     5700

tttaaatttc attatcaaac ttgggcaatt ctgtttgtgt aactccccga ctagtggatg     5760

ggagagtccc attgctaaaa ttcagctact cagataaatt cagaatgggt caaggcacct     5820

gcctgttttt gttggtgcac agagattgac ttgattcaga gagacaattc actccatccc     5880

tatggcagag gaatgggtta gccctaatgt agaatgtcat tgtttttaaa actgttttat     5940

atcttaagag tgccttatta aagtatagat gtatgtctta aaatgtgggt gataggaatt     6000

ttaaagattt atataatgca tcaaaagcct tagaataaga aaagcttttt ttaaattgct     6060

ttatctgtat atctgaactc ttgaaactta tagctaaaac actaggattt atctgcagtg     6120

ttcagggaga taattctgcc tttaattgtc taaaacaaaa acaaaaccag ccaacctatg     6180

ttacacgtga gattaaaacc aattttttcc ccattttttc tccttttttc tcttgctgcc     6240

cacattgtgc ctttatttta tgagccccag ttttctgggc ttagtttaaa aaaaaaatca     6300

agtctaaaca ttgcatttag aaagcttttg ttcttggata aaaagtcata cactttaaaa     6360

aaaaaaaaaa ctttttccag gaaaatatat tgaaatcatg ctgctgagcc tctattttct     6420

ttctttgatg ttttgattca gtattctttt atcataaatt tttagcattt aaaaattcac     6480

tgatgtacat taagccaata aactgcttta atgaataaca aactatgtag tgtgtcccta     6540

ttataaatgc attggagaag tatttttatg agactcttta ctcaggtgca tggttacagc     6600

ccacagggag gcatggagtg ccatggaagg attcgccact acccagacct tgttttttgt     6660

tgtattttgg aagacaggtt ttttaaagaa acattttcct cagattaaaa gatgatgcta     6720

ttacaactag cattgcctca aaaactggga ccaaccaaag tgtgtcaacc ctgtttcctt     6780

aaaagaggct atgaatccca aaggccacat ccaagacagg caataatgag cagagtttac     6840

agctccttta ataaaatgtg tcagtaattt taaggtttat agttccctca acacaattgc     6900

taatgcagaa tagtgtaaaa tgcgcttcaa gaatgttgat gatgatgata tagaattgtg     6960

gctttagtag cacagaggat gccccaacaa actcatggcg ttgaaaccac acagttctca     7020

ttactgttat ttattagctg tagcattctc tgtctcctct ctctcctcct ttgaccttct     7080

cctcgaccag ccatcatgac atttaccatg aatttacttc ctcccaagag tttggactgc     7140

ccgtcagatt gttgctgcac atagttgcct ttgtatctct gtatgaaata aaaggtcatt     7200

tgttcatgtt aaaaaaaaa                                                  7219


<210>  62
<211>  1657
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


