                         SEQUENCE LISTING

<110>  Tesfaigzi, Yohannes
 
<120>  COMPOSITION AND METHOD FOR TREATING LUNG DISEASE AND MUCUS CELL 
       METAPLASIA

<130>  33520-PCT

<140>  TBA
<141>  2012-02-21

<150>  US 61/444,957
<151>  2011-02-21

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be Norleucine or any other amino acid

<400>  1

Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Xaa Ile Gly Asp Xaa 
1               5                   10                  15      


Xaa Asp Val Ser Leu Arg Ala 
            20              


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be norleucine or any other amino acid

<400>  2

Ala Arg Leu Ile Gly Glu Ser Val Ala Asp Ser Xaa Asp Ala Leu Xaa 
1               5                   10                  15      


Xaa Leu Ala Arg Asp Gly Leu 
            20              


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be norleucine or any other amino acid

<400>  3

Glu Gly Ser Asp Ala Leu Ala Leu Arg Gly Ala Xaa Ile Gly Asp Xaa 
1               5                   10                  15      


Xaa Asp Val Ser Leu Arg Ala 
            20              


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X can be norleucine or any other amino acid

<400>  4

Ala Leu Ala Leu Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val Ser 
1               5                   10                  15      


Leu Arg Ala 
            


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(11)
<223>  X can be any amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X can be norleucine or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(19)
<223>  X can be any amino acid

<400>  5

Xaa Xaa Xaa Xaa Leu Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X can be norleucine or any other amino acid

<400>  6

Ala Leu Ala Leu Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be norleucine or any other amino acid

<400>  7

Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val Ser Leu Arg Ala 
1               5                   10                  15  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be norleucine or any other amino acid

<400>  8

Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be noleucine or any other amino acid

<400>  9

Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp 
1               5                   


<210>  10
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be norleucine or any other amino acid

<400>  10

Glu Gly Ser Asp Ala Leu Ala Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa 
1               5                   10                  15      


Asp Val Ser Leu Arg Ala 
            20          


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X can be norleucine or any other amino acid

<400>  11

Ala Thr Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val Ser Leu Arg Ala 
1               5                   10                  15      


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X can be norleucine or any other amino acid

<400>  12

Ala Leu Ala Arg Leu Ala Xaa Ile Gly Xaa Xaa Asp Val 
1               5                   10              


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be norleucine or any other amino acid

<400>  13

Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val Ser Leu Arg Ala 
1               5                   10                  15  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be norleucine or any other amino acid

<400>  14

Arg Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp Val 
1               5                   10      


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be norleucine or any other amino acid

<400>  15

Leu Ala Xaa Ile Gly Asp Xaa Xaa Asp 
1               5                   


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be norleucine or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<400>  16

Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Ser Ile Gly Asp Xaa 
1               5                   10                  15      


Xaa Asp Val Xaa Leu Arg Ala Lys 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be norleucine or any other amino acid

<400>  17

Glu Gly Ser Xaa Ala Leu Ala Xaa Arg Leu Ala Ser Ile Gly Asp Glu 
1               5                   10                  15      


Xaa Asp Val Ser Leu Arg Ala Lys 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence derived from the Bcl-2 homology region 3 of Bik


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X can be norleucine or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X can be (S)-2(2'-pentenyl)Ala or any other amino acid

<400>  18

Glu Gly Ser Xaa Ala Leu Ala Xaa Arg Leu Ala Ser Ile Gly Asp Xaa 
1               5                   10                  15      


Xaa Asp Val Xaa Leu Arg Ala Lys 
            20                  


