                         SEQUENCE LISTING

<110>  Monell Institute
       Givaudan SA
       Huang, Liquan
       Iguchi, Naoko
       Wang , Hong
       Slack, Jay
       Zhong, Ping
 
<120>  Method to identify compounds

<130>  30303/US

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  3030
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (22)..(3021)

<400>  1
gcggccggcc ggggaagcag c atg gag gag gcg cac ctg ctc tcg gct gcc       51
                        Met Glu Glu Ala His Leu Leu Ser Ala Ala         
                        1               5                   10          

gac gtg ctg cgt cgc ttc tcg gtg aca gcc gag ggc ggc ttg acc ctg       99
Asp Val Leu Arg Arg Phe Ser Val Thr Ala Glu Gly Gly Leu Thr Leu         
                15                  20                  25              

gag cag gtg acc gac gcc cgg gag cga tac ggc ccc aac gaa ctc cct      147
Glu Gln Val Thr Asp Ala Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro         
            30                  35                  40                  

act gag gaa ggg aaa tcc ctg tgg gag ctg gtg gtg gag cag ttt gag      195
Thr Glu Glu Gly Lys Ser Leu Trp Glu Leu Val Val Glu Gln Phe Glu         
        45                  50                  55                      

gac ctc ttg gtg cgc atc ctg ctg ctg gca gcc ctg gtt tcc ttt gtc      243
Asp Leu Leu Val Arg Ile Leu Leu Leu Ala Ala Leu Val Ser Phe Val         
    60                  65                  70                          

ctg gcc tgg ttt gag gag ggt gag gag acc acg acg gcc ttc gtg gag      291
Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr Thr Thr Ala Phe Val Glu         
75                  80                  85                  90          

ccc ctc gtc atc atg tta atc ctt gtg gcc aat gcg atc gtg gga gtg      339
Pro Leu Val Ile Met Leu Ile Leu Val Ala Asn Ala Ile Val Gly Val         
                95                  100                 105             

tgg cag gaa cgc aat gct gag agt gcc att gag gcc ttg aag gag tat      387
Trp Gln Glu Arg Asn Ala Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr         
            110                 115                 120                 

gag cct gag atg ggt aag gtg atc cgc tct gac cgc aag ggt gtg cag      435
Glu Pro Glu Met Gly Lys Val Ile Arg Ser Asp Arg Lys Gly Val Gln         
        125                 130                 135                     

agg atc cga gcc agg gac atc gtc cct ggg gac att gtg gaa gtg gca      483
Arg Ile Arg Ala Arg Asp Ile Val Pro Gly Asp Ile Val Glu Val Ala         
    140                 145                 150                         

gtg gga gac aag gta cct gct gac ctc cgc ctc atc gag atc aag tcc      531
Val Gly Asp Lys Val Pro Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser         
155                 160                 165                 170         

acc aca ctt cga gtg gac cag tcc atc ctg aca ggg gaa tcc gtg tct      579
Thr Thr Leu Arg Val Asp Gln Ser Ile Leu Thr Gly Glu Ser Val Ser         
                175                 180                 185             

gtg act aag cac aca gat gcc att cca gac ccc cga gcc gtg aac cag      627
Val Thr Lys His Thr Asp Ala Ile Pro Asp Pro Arg Ala Val Asn Gln         
            190                 195                 200                 

gac aag aag aac atg ctg ttt tct ggc acc aat att gca tca ggc aaa      675
Asp Lys Lys Asn Met Leu Phe Ser Gly Thr Asn Ile Ala Ser Gly Lys         
        205                 210                 215                     

gcc ctg ggt gtg gct gtg gcc aca ggc ttg cac aca gag ctg ggc aag      723
Ala Leu Gly Val Ala Val Ala Thr Gly Leu His Thr Glu Leu Gly Lys         
    220                 225                 230                         

att cgg agc cag atg gcg gct gtg gag cct gag cgg acg cca ctg cag      771
Ile Arg Ser Gln Met Ala Ala Val Glu Pro Glu Arg Thr Pro Leu Gln         
235                 240                 245                 250         

cgc aag ctg gat gaa ttt ggg agg cag ctg tcc cat gcc atc tct gtg      819
Arg Lys Leu Asp Glu Phe Gly Arg Gln Leu Ser His Ala Ile Ser Val         
                255                 260                 265             

atc tgt gtg gct gtg tgg gtc atc aac atc gga cac ttt gct gac ccg      867
Ile Cys Val Ala Val Trp Val Ile Asn Ile Gly His Phe Ala Asp Pro         
            270                 275                 280                 

gcc cat ggt gga tcc tgg ctc cgt ggg gca gtc tac tac ttc aag att      915
Ala His Gly Gly Ser Trp Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile         
        285                 290                 295                     

gct gtg gcc ctg gct gtg gct gct atc ccc gag ggc ctc cca gca gtc      963
Ala Val Ala Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val         
    300                 305                 310                         

atc act aca tgc cta gca ctg ggc aca aga cgt atg gca cgt aag aac     1011
Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg Met Ala Arg Lys Asn         
315                 320                 325                 330         

gcc att gtg cgg agc ctg ccc tct gtg gag acc ctg ggc tgc acc tca     1059
Ala Ile Val Arg Ser Leu Pro Ser Val Glu Thr Leu Gly Cys Thr Ser         
                335                 340                 345             

gtc atc tgc tct gac aag aca ggg aca ctc acc acc aat caa atg tct     1107
Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Gln Met Ser         
            350                 355                 360                 

gtc tgc agg atg ttc gtg gta gct gaa gca gag gca ggc gcc tgt cgt     1155
Val Cys Arg Met Phe Val Val Ala Glu Ala Glu Ala Gly Ala Cys Arg         
        365                 370                 375                     

tta cac gaa ttc acc att tcg ggt acc acg tat acc cca gag ggc gaa     1203
Leu His Glu Phe Thr Ile Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu         
    380                 385                 390                         

gtg agg caa ggg gaa cag ctt gtg cgc tgt ggg cag ttt gat gga ctt     1251
Val Arg Gln Gly Glu Gln Leu Val Arg Cys Gly Gln Phe Asp Gly Leu         
395                 400                 405                 410         

gtg gag ctc gca acc atc tgt gca ctc tgc aat gat tct gca ctg gac     1299
Val Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp         
                415                 420                 425             

tac aat gag gcc aag ggt gtg tat gag aag gta gga gag gcc aca gag     1347
Tyr Asn Glu Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Thr Glu         
            430                 435                 440                 

aca gcc ctc act tgc ctg gta gag aag atg aac gtg ttt gac aca gac     1395
Thr Ala Leu Thr Cys Leu Val Glu Lys Met Asn Val Phe Asp Thr Asp         
        445                 450                 455                     

ctg aaa gga ctg tcg cgg gtc gag cgc gct ggt gcc tgc aat tcc gtc     1443
Leu Lys Gly Leu Ser Arg Val Glu Arg Ala Gly Ala Cys Asn Ser Val         
    460                 465                 470                         

atc aag caa ctc atg cag aag gag ttc acc ctc gaa ttc tcc cgg gac     1491
Ile Lys Gln Leu Met Gln Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp         
475                 480                 485                 490         

cgg aag tcc atg tct gtg tac tgc aca ccc act cgt gct gac ccc aag     1539
Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Thr Arg Ala Asp Pro Lys         
                495                 500                 505             

gcc cag ggc agc aag atg ttt gtg aag gga gct cct gag agt gta att     1587
Ala Gln Gly Ser Lys Met Phe Val Lys Gly Ala Pro Glu Ser Val Ile         
            510                 515                 520                 

gag cgc tgc agc tca gtc cgc gtg gga agc cga aca gta ccc cta agc     1635
Glu Arg Cys Ser Ser Val Arg Val Gly Ser Arg Thr Val Pro Leu Ser         
        525                 530                 535                     

gcc acc tcc aga gag cat atc ctg gcc aag atc cga gac tgg ggc tca     1683
Ala Thr Ser Arg Glu His Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser         
    540                 545                 550                         

ggc tct gat aca ttg cgc tgc tta gca ctg gcc acc agg gac aca ccc     1731
Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro         
555                 560                 565                 570         

cca agg aag gag gac atg caa ctg gat gac tgc agt cag ttt gta cag     1779
Pro Arg Lys Glu Asp Met Gln Leu Asp Asp Cys Ser Gln Phe Val Gln         
                575                 580                 585             

tac gag aca ggc ctg acc ttc gtg ggc tgc gtg ggc atg tta gac cca     1827
Tyr Glu Thr Gly Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro         
            590                 595                 600                 

ccg aga cca gag gtg gct gcc tgt atc aca cgc tgt tct cgg gcg ggc     1875
Pro Arg Pro Glu Val Ala Ala Cys Ile Thr Arg Cys Ser Arg Ala Gly         
        605                 610                 615                     

att cga gtg gtc atg atc aca ggg gac aac aaa ggg aca gct gtg gcc     1923
Ile Arg Val Val Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala         
    620                 625                 630                         

atc tgc cgc cga ctt ggc atc ttt ggg gat acg gag gat gtg ttg ggc     1971
Ile Cys Arg Arg Leu Gly Ile Phe Gly Asp Thr Glu Asp Val Leu Gly         
635                 640                 645                 650         

aag gct tac acg ggc cga gaa ttc gat gac ctc agc cca gag cag cag     2019
Lys Ala Tyr Thr Gly Arg Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln         
                655                 660                 665             

cgc cag gct tgc cgt acc gcc cga tgc ttt gcc cgt gtg gaa ccc gca     2067
Arg Gln Ala Cys Arg Thr Ala Arg Cys Phe Ala Arg Val Glu Pro Ala         
            670                 675                 680                 

cat aag tct cgc atc gtg gag aac ctc cag tcc ttt aat gag atc acc     2115
His Lys Ser Arg Ile Val Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr         
        685                 690                 695                     

gcc atg act ggc gat ggg gtg aat gat gca cca gcc ctg aag aag gca     2163
Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala         
    700                 705                 710                         

gag atc ggc atc gcc atg ggc tca ggc act gct gtg gcc aag tcg gca     2211
Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Ser Ala         
715                 720                 725                 730         

gcg gag atg gtt ctg tct gat gac aac ttt gcc tcc att gtg gct gca     2259
Ala Glu Met Val Leu Ser Asp Asp Asn Phe Ala Ser Ile Val Ala Ala         
                735                 740                 745             

gtg gag gag ggc agg gcc atc tac aac aac atg aag caa ttc atc cgc     2307
Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg         
            750                 755                 760                 

tac ctc atc tcc tcc aat gtt ggc gag gtt gtc tgc atc ttc ctc aca     2355
Tyr Leu Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr         
        765                 770                 775                     

gca att ctg ggc ctg ccc gaa gcc ctg atc cct gtg cag ctg ctc tgg     2403
Ala Ile Leu Gly Leu Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp         
    780                 785                 790                         

gtg aac ctg gta aca gat ggc tta cct gcc aca gcc ctt ggc ttc aac     2451
Val Asn Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn         
795                 800                 805                 810         

cca ccc gat ctg gac atc atg gaa aag ctg cct cgg aac ccc cgg gag     2499
Pro Pro Asp Leu Asp Ile Met Glu Lys Leu Pro Arg Asn Pro Arg Glu         
                815                 820                 825             

gct ctc atc agc ggc tgg ctt ttt ttc cgc tat ttg gct att gga gtg     2547
Ala Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val         
            830                 835                 840                 

tac gta ggc ctg gct aca gtg gct gcc gcc acc tgg tgg ttc ctg tat     2595
Tyr Val Gly Leu Ala Thr Val Ala Ala Ala Thr Trp Trp Phe Leu Tyr         
        845                 850                 855                     

gac gct gag gga cca caa gtc acc ttc cat cag ctg agg aac ttc ctg     2643
Asp Ala Glu Gly Pro Gln Val Thr Phe His Gln Leu Arg Asn Phe Leu         
    860                 865                 870                         

aag tgc tct gaa gac aat cca ctg ttt gcc ggc atc gac tgc gag gtc     2691
Lys Cys Ser Glu Asp Asn Pro Leu Phe Ala Gly Ile Asp Cys Glu Val         
875                 880                 885                 890         

ttt gag tca cgc ttc ccc acg acc atg gcc tta tct gtg ctt gtg acc     2739
Phe Glu Ser Arg Phe Pro Thr Thr Met Ala Leu Ser Val Leu Val Thr         
                895                 900                 905             

att gaa atg tgc aac gcc ctt aac agc gtc tca gag aac cag tca ctg     2787
Ile Glu Met Cys Asn Ala Leu Asn Ser Val Ser Glu Asn Gln Ser Leu         
            910                 915                 920                 

ctg cgt atg cca ccc tgg ctg aac cct tgg ctg ctg ggg gct gtg gtc     2835
Leu Arg Met Pro Pro Trp Leu Asn Pro Trp Leu Leu Gly Ala Val Val         
        925                 930                 935                     

atg tcc atg gcc ctg cat ttt ctc atc ctt ttg gtg ccg cct ctg ccc     2883
Met Ser Met Ala Leu His Phe Leu Ile Leu Leu Val Pro Pro Leu Pro         
    940                 945                 950                         

ctc att ttc cag gtg acc cca ctg agt ggt cga cag tgg ggg gtg gtg     2931
Leu Ile Phe Gln Val Thr Pro Leu Ser Gly Arg Gln Trp Gly Val Val         
955                 960                 965                 970         

ctt cag atg tct ctg cct gtc atc ctg ctt gac gag gcc ctc aag tat     2979
Leu Gln Met Ser Leu Pro Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr         
                975                 980                 985             

ctg tcc agg cat cac gtg gat gaa aaa aag gac ctg aag taa atcctgaga   3030
Leu Ser Arg His His Val Asp Glu Lys Lys Asp Leu Lys                     
            990                 995                                     


<210>  2
<211>  999
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Glu Glu Ala His Leu Leu Ser Ala Ala Asp Val Leu Arg Arg Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Thr Leu Glu Gln Val Thr Asp Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Thr Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Val Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Asp 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ser Gly Lys Ala Leu Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Glu Ala Gly Ala Cys Arg Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Glu Gln 
385                 390                 395                 400 


Leu Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Lys Gly Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Ser Val Ile Lys Gln Leu Met Gln 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Ala Asp Pro Lys Ala Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Val Pro Leu Ser Ala Thr Ser Arg Glu His 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Gln Leu Asp Asp Cys Ser Gln Phe Val Gln Tyr Glu Thr Gly Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Ser Arg Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Leu Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Asn Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Leu Tyr Asp Ala Glu Gly Pro Gln 
    850                 855                 860                 


Val Thr Phe His Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Leu Asn Pro Trp Leu Leu Gly Ala Val Val Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Gly Val Val Leu Gln Met Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg His His Val 
            980                 985                 990         


Asp Glu Lys Lys Asp Leu Lys 
        995                 


<210>  3
<211>  3136
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (42)..(3041)

<400>  3
ggagaagcga cctggacgtc gcggacggcc gggcaggcag c atg gag gag gcg cac     56
                                              Met Glu Glu Ala His       
                                              1               5         

ctg ctc tcc gct gcc gac gtg ctg cgt cgc ttc tcg gtg aca gcc gag      104
Leu Leu Ser Ala Ala Asp Val Leu Arg Arg Phe Ser Val Thr Ala Glu         
                10                  15                  20              

ggc ggc ttg agc ctg gag cag gtg acc gac gcg cgg gag cgt tac ggc      152
Gly Gly Leu Ser Leu Glu Gln Val Thr Asp Ala Arg Glu Arg Tyr Gly         
            25                  30                  35                  

ccc aac gag ctc ccg acc gag gaa ggg aaa tcc ctg tgg gag ctg gtg      200
Pro Asn Glu Leu Pro Thr Glu Glu Gly Lys Ser Leu Trp Glu Leu Val         
        40                  45                  50                      

gtg gag cag ttt gag gac ctc ttg gtg cgc atc ctg ctg ctg gca gct      248
Val Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu Leu Leu Ala Ala         
    55                  60                  65                          

ctg gtt tcc ttt gtc ctg gcc tgg ttc gag gag ggt gag gag acc aca      296
Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr Thr         
70                  75                  80                  85          

acg gcc ttc gtg gag ccc ctg gtc atc atg cta att ctc gtg gcc aat      344
Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile Leu Val Ala Asn         
                90                  95                  100             

gcg atc gtg gga gtg tgg cag gaa cgc aac gca gag agt gca att gag      392
Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu Ser Ala Ile Glu         
            105                 110                 115                 

gcc ttg aag gag tat gag cct gag atg ggt aag gtg atc cgg tct gac      440
Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val Ile Arg Ser Asp         
        120                 125                 130                     

cgc aag ggt gta cag agg atc cga gcc agg gac atc gtc cct ggg gac      488
Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile Val Pro Gly Asp         
    135                 140                 145                         

att gtg gaa gtg gca gtg gga gac aag gta ccc gct gac ctc cgt ctc      536
Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala Asp Leu Arg Leu         
150                 155                 160                 165         

atc gag atc aag tcc acc aca ctt cga gtg gac cag tcc atc ctg aca      584
Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln Ser Ile Leu Thr         
                170                 175                 180             

ggg gaa tcc gtg tct gtg acg aag cac aca gat gcc att cca gac ccc      632
Gly Glu Ser Val Ser Val Thr Lys His Thr Asp Ala Ile Pro Asp Pro         
            185                 190                 195                 

cga gcc gtg aac cag gac aag aag aac atg cta ttt tct ggc acc aat      680
Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe Ser Gly Thr Asn         
        200                 205                 210                     

att gca tca ggc aaa gcc ctg ggt gtg gct gtg gct aca ggc ctg cag      728
Ile Ala Ser Gly Lys Ala Leu Gly Val Ala Val Ala Thr Gly Leu Gln         
    215                 220                 225                         

aca gag ctg ggc aag att cgg agc cag atg gcg gct gtg gag cct gag      776
Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala Val Glu Pro Glu         
230                 235                 240                 245         

cgg acg cca ttg cag cgc aag ctg gat gaa ttt ggg agg cag ctg tcc      824
Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly Arg Gln Leu Ser         
                250                 255                 260             

cat gcc atc tct gtg atc tgt gtg gct gtg tgg gtc atc aac atc ggc      872
His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val Ile Asn Ile Gly         
            265                 270                 275                 

cac ttt gct gac ccg gcc cac ggt gga tcc tgg ctc cgt ggt gca gtc      920
His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu Arg Gly Ala Val         
        280                 285                 290                     

tac tac ttc aag atc gct gtg gcc ctg gct gtg gct gct atc ccc gag      968
Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala Ala Ile Pro Glu         
    295                 300                 305                         

ggt ctc cca gca gtc atc act aca tgc ctg gcc ctg ggc aca aga cgt     1016
Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg         
310                 315                 320                 325         

atg gca cgt aag aat gcc att gtg cgg agc ctg cct tct gtg gag acg     1064
Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro Ser Val Glu Thr         
                330                 335                 340             

ctg ggc tgc acc tcg gtc atc tgc tct gac aag acg ggg acg ctc acc     1112
Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr         
            345                 350                 355                 

acc aat cag atg tct gtc tgc agg atg ttc gtg gtg gct gaa gca gag     1160
Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val Ala Glu Ala Glu         
        360                 365                 370                     

gca ggc acc tgt cgt ttg cat gaa ttc acc att tcg ggt acc acg tac     1208
Ala Gly Thr Cys Arg Leu His Glu Phe Thr Ile Ser Gly Thr Thr Tyr         
    375                 380                 385                         

acc cca gag ggc gaa gtg agg caa ggg gag cag cct gtg cgc tgt ggg     1256
Thr Pro Glu Gly Glu Val Arg Gln Gly Glu Gln Pro Val Arg Cys Gly         
390                 395                 400                 405         

cag ttt gat ggg cta gtg gag ctc gcc acc atc tgt gcc ctc tgc aat     1304
Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn         
                410                 415                 420             

gat tct gcg ctg gac tac aat gag gcc aag ggt gtg tat gag aag gta     1352
Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val Tyr Glu Lys Val         
            425                 430                 435                 

gga gag gcc aca gag acc gcc ctg act tgc ctg gta gag aag atg aat     1400
Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val Glu Lys Met Asn         
        440                 445                 450                     

gtg ttt gac aca gac ctg aaa gga ctg tcg cgg gtg gag cgt gct ggc     1448
Val Phe Asp Thr Asp Leu Lys Gly Leu Ser Arg Val Glu Arg Ala Gly         
    455                 460                 465                         

gcc tgc aac tca gtc atc aag caa ctc atg cgg aaa gag ttc acc ctg     1496
Ala Cys Asn Ser Val Ile Lys Gln Leu Met Arg Lys Glu Phe Thr Leu         
470                 475                 480                 485         

gag ttc tcc cgg gac cgg aag tct atg tcc gtg tac tgc aca cct act     1544
Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Thr         
                490                 495                 500             

cgt gct gac ccc aag gtc cag ggc agc aag atg ttt gtg aag gga gct     1592
Arg Ala Asp Pro Lys Val Gln Gly Ser Lys Met Phe Val Lys Gly Ala         
            505                 510                 515                 

cct gag agt gta att gag cgc tgt agc tca gtc cga gtg ggc agc cga     1640
Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg Val Gly Ser Arg         
        520                 525                 530                     

aca gca ccc ctg agc acc act tcc aga gag cat atc ctg gcc aag atc     1688
Thr Ala Pro Leu Ser Thr Thr Ser Arg Glu His Ile Leu Ala Lys Ile         
    535                 540                 545                         

cgg gac tgg ggc tca ggc tct gac aca ctg cgc tgc tta gcc ttg gcc     1736
Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu Ala         
550                 555                 560                 565         

acc agg gac aca ccc cca agg aag gag gac atg cat cta gat gac tgc     1784
Thr Arg Asp Thr Pro Pro Arg Lys Glu Asp Met His Leu Asp Asp Cys         
                570                 575                 580             

agc cgg ttt gta cag tac gag aca gac ctg acc ttc gtg ggc tgc gtg     1832
Ser Arg Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe Val Gly Cys Val         
            585                 590                 595                 

ggc atg tta gac cca ccg aga cca gag gtg gct gct tgt atc aca cgc     1880
Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala Cys Ile Thr Arg         
        600                 605                 610                     

tgt tcc cgg gct ggc att cga gtg gtc atg atc aca ggg gac aac aaa     1928
Cys Ser Arg Ala Gly Ile Arg Val Val Met Ile Thr Gly Asp Asn Lys         
    615                 620                 625                         

ggg aca gct gtg gcc atc tgc cgc cga ctt ggc atc ttt ggg gac acg     1976
Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile Phe Gly Asp Thr         
630                 635                 640                 645         

gag gat gtg ttg ggc aag gcc tac acg ggc cgt gag ttt gat gac ctc     2024
Glu Asp Val Leu Gly Lys Ala Tyr Thr Gly Arg Glu Phe Asp Asp Leu         
                650                 655                 660             

agc cca gag cag cag cgc cag gct tgt cgc act gcc cgg tgc ttt gcc     2072
Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala Arg Cys Phe Ala         
            665                 670                 675                 

cga gtg gaa ccc gca cat aag tct cga atc gtg gag aac cta cag tcc     2120
Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu Asn Leu Gln Ser         
        680                 685                 690                     

ttt aat gag atc act gcc atg act ggc gat ggg gtg aat gat gca cca     2168
Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro         
    695                 700                 705                         

gcc ctg aag aag gca gag atc ggc atc gcc atg ggc tca ggc act gct     2216
Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala         
710                 715                 720                 725         

gtg gcc aag tca gca gca gag atg gtg ctg tcc gat gac aac ttt gcc     2264
Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp Asp Asn Phe Ala         
                730                 735                 740             

tcc att gtg gct gca gta gaa gag ggc agg gcc atc tac aac aac atg     2312
Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met         
            745                 750                 755                 

aag cag ttc atc cgc tac ctc atc tcc tcc aat gtt ggc gag gtt gtc     2360
Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly Glu Val Val         
        760                 765                 770                     

tgc atc ttc ctc aca gca att ctg ggc ctg ccc gaa gct ctg atc cct     2408
Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu Ala Leu Ile Pro         
    775                 780                 785                         

gtg cag ctg ctc tgg gtg aac ctg gta aca gat ggc tta ccg gcc aca     2456
Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala Thr         
790                 795                 800                 805         

gcc ctt ggc ttc aac cca cca gat ctg gat atc atg gag aag ccg cct     2504
Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met Glu Lys Pro Pro         
                810                 815                 820             

cgg aat ccc cgt gag gcc ctc atc agt ggc tgg ctt ttt ttc cgc tat     2552
Arg Asn Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr         
            825                 830                 835                 

ttg gct att gga gtg tat gta ggc ctg gct aca gtg gct gcc gcc acc     2600
Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val Ala Ala Ala Thr         
        840                 845                 850                     

tgg tgg ttc ctg tat gac acc gag gga cct caa gtc acc ttc tat cag     2648
Trp Trp Phe Leu Tyr Asp Thr Glu Gly Pro Gln Val Thr Phe Tyr Gln         
    855                 860                 865                         

ctg agg aac ttc ctg aag tgc tct gaa gac aat cca ctg ttt gct ggc     2696
Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro Leu Phe Ala Gly         
870                 875                 880                 885         

att gac tgc aag gtt ttt gag tca cgc ttc ccc aca acc atg gcc tta     2744
Ile Asp Cys Lys Val Phe Glu Ser Arg Phe Pro Thr Thr Met Ala Leu         
                890                 895                 900             

tct gtg ctt gtg acc att gaa atg tgc aac gcc ctc aac agc gtc tct     2792
Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu Asn Ser Val Ser         
            905                 910                 915                 

gag aac cag tca ctg ctg cgc atg cca ccc tgg ctg aac cct tgg ctg     2840
Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Leu Asn Pro Trp Leu         
        920                 925                 930                     

ctg ggg gct gtg gtc atg tcc atg gct ctg cat ttt ctt atc ctc ctg     2888
Leu Gly Ala Val Val Met Ser Met Ala Leu His Phe Leu Ile Leu Leu         
    935                 940                 945                         

gtg cca cct ctg cct ctc att ttt cag gtg acc cca ctg agt ggt cgg     2936
Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro Leu Ser Gly Arg         
950                 955                 960                 965         

cag tgg ggg gtg gtg ctt cag atg tct ctg cct gtc atc ctg ctc gat     2984
Gln Trp Gly Val Val Leu Gln Met Ser Leu Pro Val Ile Leu Leu Asp         
                970                 975                 980             

gag gcc ctc aag tat ctg tcc agg aat cac atg gat gaa aaa aag gac     3032
Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met Asp Glu Lys Lys Asp         
            985                 990                 995                 

ctg aag taa atcctgggag cagaggggag tctccagtgt ggccctcaga             3081
Leu Lys                                                                 
                                                                        

ctgagagcat ccaggcattt gtcctgttcc cacccctgcc tccacactca gccac        3136


<210>  4
<211>  999
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Glu Ala His Leu Leu Ser Ala Ala Asp Val Leu Arg Arg Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Leu Glu Gln Val Thr Asp Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Thr Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Val Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Asp 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ser Gly Lys Ala Leu Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu Gln Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Glu Ala Gly Thr Cys Arg Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Glu Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Lys Gly Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Ser Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Ala Asp Pro Lys Val Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Ser Thr Thr Ser Arg Glu His 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


His Leu Asp Asp Cys Ser Arg Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Ser Arg Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Leu Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Pro Pro Arg Asn Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Leu Tyr Asp Thr Glu Gly Pro Gln 
    850                 855                 860                 


Val Thr Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Lys Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Leu Asn Pro Trp Leu Leu Gly Ala Val Val Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Gly Val Val Leu Gln Met Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


Asp Glu Lys Lys Asp Leu Lys 
        995                 


<210>  5
<211>  3211
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (44)..(3160)

<400>  5
gaggagaagc gacctggacg tcgcggacgg ccgggcaggc agc atg gag gag gcg       55
                                                Met Glu Glu Ala         
                                                1                       

cac ctg ctc tcc gct gcc gac gtg ctg cgt cgc ttc tcg gtg aca gcc      103
His Leu Leu Ser Ala Ala Asp Val Leu Arg Arg Phe Ser Val Thr Ala         
5                   10                  15                  20          

gag ggc ggc ttg agc ctg gag cag gtg acc gac gcg cgg gag cgt tac      151
Glu Gly Gly Leu Ser Leu Glu Gln Val Thr Asp Ala Arg Glu Arg Tyr         
                25                  30                  35              

ggc ccc aac gag ctc ccg acc gag gaa ggg aaa tcc ctg tgg gag ctg      199
Gly Pro Asn Glu Leu Pro Thr Glu Glu Gly Lys Ser Leu Trp Glu Leu         
            40                  45                  50                  

gtg gtg gag cag ttt gag gac ctc ttg gtg cgc atc ctg ctg ctg gca      247
Val Val Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu Leu Leu Ala         
        55                  60                  65                      

gct ctg gtt tcc ttt gtc ctg gcc tgg ttc gag gag ggt gag gag acc      295
Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr         
    70                  75                  80                          

aca acg gcc ttc gtg gag ccc ctg gtc atc atg cta att ctc gtg gcc      343
Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile Leu Val Ala         
85                  90                  95                  100         

aat gcg atc gtg gga gtg tgg cag gaa cgc aac gca gag agt gca att      391
Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu Ser Ala Ile         
                105                 110                 115             

gag gcc ttg aag gag tat gag cct gag atg ggt aag gtg atc cgg tct      439
Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val Ile Arg Ser         
            120                 125                 130                 

gac cgc aag ggt gta cag agg atc cga gcc agg gac atc gtc cct ggg      487
Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile Val Pro Gly         
        135                 140                 145                     

gac att gtg gaa gtg gca gtg gga gac aag gta ccc gct gac ctc cgt      535
Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala Asp Leu Arg         
    150                 155                 160                         

ctc atc gag atc aag tcc acc aca ctt cga gtg gac cag tcc atc ctg      583
Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln Ser Ile Leu         
165                 170                 175                 180         

aca ggg gaa tcc gtg tct gtg acg aag cac aca gat gcc att cca gac      631
Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Asp Ala Ile Pro Asp         
                185                 190                 195             

ccc cga gcc gtg aac cag gac aag aag aac atg cta ttt tct ggc acc      679
Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe Ser Gly Thr         
            200                 205                 210                 

aat att gca tca ggc aaa gcc ctg ggt gtg gct gtg gct aca ggc ctg      727
Asn Ile Ala Ser Gly Lys Ala Leu Gly Val Ala Val Ala Thr Gly Leu         
        215                 220                 225                     

cag aca gag ctg ggc aag att cgg agc cag atg gcg gct gtg gag cct      775
Gln Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala Val Glu Pro         
    230                 235                 240                         

gag cgg acg cca ttg cag cgc aag ctg gat gaa ttt ggg agg cag ctg      823
Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly Arg Gln Leu         
245                 250                 255                 260         

tcc cat gcc atc tct gtg atc tgt gtg gct gtg tgg gtc atc aac atc      871
Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val Ile Asn Ile         
                265                 270                 275             

ggc cac ttt gct gac ccg gcc cac ggt gga tcc tgg ctc cgt ggt gca      919
Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu Arg Gly Ala         
            280                 285                 290                 

gtc tac tac ttc aag atc gct gtg gcc ctg gct gtg gct gct atc ccc      967
Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala Ala Ile Pro         
        295                 300                 305                     

gag ggt ctc cca gca gtc atc act aca tgc ctg gcc ctg ggc aca aga     1015
Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg         
    310                 315                 320                         

cgt atg gca cgt aag aat gcc att gtg cgg agc ctg cct tct gtg gag     1063
Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro Ser Val Glu         
325                 330                 335                 340         

acg ctg ggc tgc acc tcg gtc atc tgc tct gac aag acg ggg acg ctc     1111
Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr Gly Thr Leu         
                345                 350                 355             

acc acc aat cag atg tct gtc tgc agg atg ttc gtg gtg gct gaa gca     1159
Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val Ala Glu Ala         
            360                 365                 370                 

gag gca ggc acc tgt cgt ttg cat gaa ttc acc att tcg ggt acc acg     1207
Glu Ala Gly Thr Cys Arg Leu His Glu Phe Thr Ile Ser Gly Thr Thr         
        375                 380                 385                     

tac acc cca gag ggc gaa gtg agg caa ggg gag cag cct gtg cgc tgt     1255
Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Glu Gln Pro Val Arg Cys         
    390                 395                 400                         

ggg cag ttt gat ggg cta gtg gag ctc gcc acc atc tgt gcc ctc tgc     1303
Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys Ala Leu Cys         
405                 410                 415                 420         

aat gat tct gcg ctg gac tac aat gag gcc aag ggt gtg tat gag aag     1351
Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val Tyr Glu Lys         
                425                 430                 435             

gta gga gag gcc aca gag acc gcc ctg act tgc ctg gta gag aag atg     1399
Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val Glu Lys Met         
            440                 445                 450                 

aat gtg ttt gac aca gac ctg aaa gga ctg tcg cgg gtg gag cgt gct     1447
Asn Val Phe Asp Thr Asp Leu Lys Gly Leu Ser Arg Val Glu Arg Ala         
        455                 460                 465                     

ggc gcc tgc aac tca gtc atc aag caa ctc atg cgg aaa gag ttc acc     1495
Gly Ala Cys Asn Ser Val Ile Lys Gln Leu Met Arg Lys Glu Phe Thr         
    470                 475                 480                         

ctg gag ttc tcc cgg gac cgg aag tct atg tcc gtg tac tgc aca cct     1543
Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro         
485                 490                 495                 500         

act cgt gct gac ccc aag gtc cag ggc agc aag atg ttt gtg aag gga     1591
Thr Arg Ala Asp Pro Lys Val Gln Gly Ser Lys Met Phe Val Lys Gly         
                505                 510                 515             

gct cct gag agt gta att gag cgc tgt agc tca gtc cga gtg ggc agc     1639
Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg Val Gly Ser         
            520                 525                 530                 

cga aca gca ccc ctg agc acc act tcc aga gag cat atc ctg gcc aag     1687
Arg Thr Ala Pro Leu Ser Thr Thr Ser Arg Glu His Ile Leu Ala Lys         
        535                 540                 545                     

atc cgg gac tgg ggc tca ggc tct gac aca ctg cgc tgc tta gcc ttg     1735
Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu         
    550                 555                 560                         

gcc acc agg gac aca ccc cca agg aag gag gac atg cat cta gat gac     1783
Ala Thr Arg Asp Thr Pro Pro Arg Lys Glu Asp Met His Leu Asp Asp         
565                 570                 575                 580         

tgc agc cgg ttt gta cag tac gag aca gac ctg acc ttc gtg ggc tgc     1831
Cys Ser Arg Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe Val Gly Cys         
                585                 590                 595             

gtg ggc atg tta gac cca ccg aga cca gag gtg gct gct tgt atc aca     1879
Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala Cys Ile Thr         
            600                 605                 610                 

cgc tgt tcc cgg gct ggc att cga gtg gtc atg atc aca ggg gac aac     1927
Arg Cys Ser Arg Ala Gly Ile Arg Val Val Met Ile Thr Gly Asp Asn         
        615                 620                 625                     

aaa ggg aca gct gtg gcc atc tgc cgc cga ctt ggc atc ttt ggg gac     1975
Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile Phe Gly Asp         
    630                 635                 640                         

acg gag gat gtg ttg ggc aag gcc tac acg ggc cgt gag ttt gat gac     2023
Thr Glu Asp Val Leu Gly Lys Ala Tyr Thr Gly Arg Glu Phe Asp Asp         
645                 650                 655                 660         

ctc agc cca gag cag cag cgc cag gct tgt cgc act gcc cgg tgc ttt     2071
Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala Arg Cys Phe         
                665                 670                 675             

gcc cga gtg gaa ccc gca cat aag tct cga atc gtg gag aac cta cag     2119
Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu Asn Leu Gln         
            680                 685                 690                 

tcc ttt aat gag atc act gcc atg act ggc gat ggg gtg aat gat gca     2167
Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val Asn Asp Ala         
        695                 700                 705                     

cca gcc ctg aag aag gca gag atc ggc atc gcc atg ggc tca ggc act     2215
Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly Ser Gly Thr         
    710                 715                 720                         

gct gtg gcc aag tca gca gca gag atg gtg ctg tcc gat gac aac ttt     2263
Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp Asp Asn Phe         
725                 730                 735                 740         

gcc tcc att gtg gct gca gta gaa gag ggc agg gcc atc tac aac aac     2311
Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn         
                745                 750                 755             

atg aag cag ttc atc cgc tac ctc atc tcc tcc aat gtt ggc gag gtt     2359
Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly Glu Val         
            760                 765                 770                 

gtc tgc atc ttc ctc aca gca att ctg ggc ctg ccc gaa gct ctg atc     2407
Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu Ala Leu Ile         
        775                 780                 785                     

cct gtg cag ctg ctc tgg gtg aac ctg gta aca gat ggc tta ccg gcc     2455
Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala         
    790                 795                 800                         

aca gcc ctt ggc ttc aac cca cca gat ctg gat atc atg gag aag ccg     2503
Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met Glu Lys Pro         
805                 810                 815                 820         

cct cgg aat ccc cgt gag gcc ctc atc agt ggc tgg ctt ttt ttc cgc     2551
Pro Arg Asn Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu Phe Phe Arg         
                825                 830                 835             

tat ttg gct att gga gtg tat gta ggc ctg gct aca gtg gct gcc gcc     2599
Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val Ala Ala Ala         
            840                 845                 850                 

acc tgg tgg ttc ctg tat gac acc gag gga cct caa gtc acc ttc tat     2647
Thr Trp Trp Phe Leu Tyr Asp Thr Glu Gly Pro Gln Val Thr Phe Tyr         
        855                 860                 865                     

cag ctg agg aac ttc ctg aag tgc tct gaa gac aat cca ctg ttt gct     2695
Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro Leu Phe Ala         
    870                 875                 880                         

ggc att gac tgc aag gtt ttt gag tca cgc ttc ccc aca acc atg gcc     2743
Gly Ile Asp Cys Lys Val Phe Glu Ser Arg Phe Pro Thr Thr Met Ala         
885                 890                 895                 900         

tta tct gtg ctt gtg acc att gaa atg tgc aac gcc ctc aac agc gtc     2791
Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu Asn Ser Val         
                905                 910                 915             

tct gag aac cag tca ctg ctg cgc atg cca ccc tgg ctg aac cct tgg     2839
Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Leu Asn Pro Trp         
            920                 925                 930                 

ctg ctg ggg gct gtg gtc atg tcc atg gct ctg cat ttt ctt atc ctc     2887
Leu Leu Gly Ala Val Val Met Ser Met Ala Leu His Phe Leu Ile Leu         
        935                 940                 945                     

ctg gtg cca cct ctg cct ctc att ttt cag gtg acc cca ctg agt ggt     2935
Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro Leu Ser Gly         
    950                 955                 960                         

cgg cag tgg ggg gtg gtg ctt cag atg tct ctg cct gtc atc ctg ctc     2983
Arg Gln Trp Gly Val Val Leu Gln Met Ser Leu Pro Val Ile Leu Leu         
965                 970                 975                 980         

gat gag gcc ctc aag tat ctg tcc agg aat cac atg gat ggt gtt ctc     3031
Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met Asp Gly Val Leu         
                985                 990                 995             

ggg aca ttt atg  cag gct cgg agt agg  cag ctg ccg act act  tcc      3076
Gly Thr Phe Met  Gln Ala Arg Ser Arg  Gln Leu Pro Thr Thr  Ser          
            1000                 1005                 1010              

agg acc cca tac  cac acc gga aaa aaa  gga cct gaa gta aat  cct      3121
Arg Thr Pro Tyr  His Thr Gly Lys Lys  Gly Pro Glu Val Asn  Pro          
            1015                 1020                 1025              

ggg agc aga ggg  gag tct cca gtg tgg  ccc tca gac tga gagcatccag    3170
Gly Ser Arg Gly  Glu Ser Pro Val Trp  Pro Ser Asp                       
            1030                 1035                                   

gcatttgccc tgttcccacc cctgcctcca cactcagcca c                       3211


<210>  6
<211>  1038
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Glu Ala His Leu Leu Ser Ala Ala Asp Val Leu Arg Arg Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Leu Glu Gln Val Thr Asp Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Thr Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Val Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Asp 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ser Gly Lys Ala Leu Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu Gln Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Glu Ala Gly Thr Cys Arg Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Glu Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Lys Gly Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Ser Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Ala Asp Pro Lys Val Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Ser Thr Thr Ser Arg Glu His 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


His Leu Asp Asp Cys Ser Arg Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Ser Arg Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Leu Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Pro Pro Arg Asn Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Leu Tyr Asp Thr Glu Gly Pro Gln 
    850                 855                 860                 


Val Thr Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Lys Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Leu Asn Pro Trp Leu Leu Gly Ala Val Val Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Gly Val Val Leu Gln Met Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


Asp Gly Val Leu Gly Thr Phe Met  Gln Ala Arg Ser Arg  Gln Leu Pro 
        995                 1000                 1005             


Thr Thr  Ser Arg Thr Pro Tyr  His Thr Gly Lys Lys  Gly Pro Glu 
    1010                 1015                 1020             


Val Asn  Pro Gly Ser Arg Gly  Glu Ser Pro Val Trp  Pro Ser Asp 
    1025                 1030                 1035             


<210>  7
<211>  3090
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3090)

<400>  7
atg gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc       48
Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe         
1               5                   10                  15              

tcg gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg       96
Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala         
            20                  25                  30                  

cgg gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc      144
Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser         
        35                  40                  45                      

ctg tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc      192
Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile         
    50                  55                  60                          

ctg ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag      240
Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu         
65                  70                  75                  80          

ggc gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg      288
Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu         
                85                  90                  95              

atc ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc      336
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala         
            100                 105                 110                 

gag agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag      384
Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys         
        115                 120                 125                     

gtg atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac      432
Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp         
    130                 135                 140                         

atc gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct      480
Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro         
145                 150                 155                 160         

gct gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac      528
Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp         
                165                 170                 175             

cag tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag      576
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu         
            180                 185                 190                 

gcc atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg      624
Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu         
        195                 200                 205                     

ttt tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg      672
Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val         
    210                 215                 220                         

gcc acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg      720
Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala         
225                 230                 235                 240         

gca gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt      768
Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe         
                245                 250                 255             

gga cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg      816
Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp         
            260                 265                 270                 

gtc atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg      864
Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp         
        275                 280                 285                     

ctg cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg      912
Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val         
    290                 295                 300                         

gcg gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca      960
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala         
305                 310                 315                 320         

ctg ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg     1008
Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu         
                325                 330                 335             

ccg tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag     1056
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys         
            340                 345                 350                 

acg ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg     1104
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val         
        355                 360                 365                     

gta gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc     1152
Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile         
    370                 375                 380                         

tcg ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag     1200
Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln         
385                 390                 395                 400         

cct gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc     1248
Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile         
                405                 410                 415             

tgc gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt     1296
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly         
            420                 425                 430                 

gtg tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg     1344
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu         
        435                 440                 445                     

gtg gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg     1392
Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg         
    450                 455                 460                         

gtg gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg     1440
Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg         
465                 470                 475                 480         

aag gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg     1488
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val         
                485                 490                 495             

tac tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg     1536
Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met         
            500                 505                 510                 

ttt gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc     1584
Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val         
        515                 520                 525                     

cgc gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag     1632
Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln         
    530                 535                 540                         

atc ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc     1680
Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg         
545                 550                 555                 560         

tgc ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg     1728
Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met         
                565                 570                 575             

gag ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc     1776
Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr         
            580                 585                 590                 

ttc gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct     1824
Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala         
        595                 600                 605                     

gcc tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc     1872
Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile         
    610                 615                 620                         

acg ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc     1920
Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly         
625                 630                 635                 640         

atc ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc     1968
Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg         
                645                 650                 655             

gag ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc     2016
Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr         
            660                 665                 670                 

gcc cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg     2064
Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val         
        675                 680                 685                     

gag aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga     2112
Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly         
    690                 695                 700                         

gtg aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg     2160
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met         
705                 710                 715                 720         

ggc tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca     2208
Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser         
                725                 730                 735             

gat gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc     2256
Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala         
            740                 745                 750                 

atc tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat     2304
Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn         
        755                 760                 765                     

gtt ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc     2352
Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro         
    770                 775                 780                         

gaa gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac     2400
Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp         
785                 790                 795                 800         

ggc cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc     2448
Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile         
                805                 810                 815             

atg gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg     2496
Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp         
            820                 825                 830                 

ctc ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca     2544
Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr         
        835                 840                 845                     

gtg gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac     2592
Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His         
    850                 855                 860                         

atc aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac     2640
Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn         
865                 870                 875                 880         

ccg ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc     2688
Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro         
                885                 890                 895             

acc acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc     2736
Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala         
            900                 905                 910                 

ctc aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg     2784
Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp         
        915                 920                 925                     

atg aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac     2832
Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His         
    930                 935                 940                         

ttc ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc     2880
Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr         
945                 950                 955                 960         

cca ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct     2928
Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro         
                965                 970                 975             

gtc atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg     2976
Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met         
            980                 985                 990                 

cac gcc tgt ctt tat cca ggc ctt  ctc agg aca gtc tcg  cag gcc tgg   3024
His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp       
        995                 1000                 1005                   

agt agg  cag ccg ctg acc acc  tct tgg acc cca gac  cac acc ggg      3069
Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly          
    1010                 1015                 1020                      

ttg gcc  tct ttg aag aaa tga                                        3090
Leu Ala  Ser Leu Lys Lys                                                
    1025                                                                


<210>  8
<211>  1029
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Lys Lys 
    1025                 


<210>  9
<211>  4739
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(3173)

<400>  9
atcctggcgc gggccggggc cgccgccgcc actgccgtcg ggtaaggtcc cagcacggac       60

atggcctcgc gcggcgcccg cccgggcccg agtcccccgc gccccgcttt gtagcccccc      120

ggcggagagg cggcctcgac ggtgcggacg gcgcagacgg ccgggcgggc ggc atg         176
                                                           Met            
                                                           1              

gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc tcg        224
Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe Ser           
            5                   10                  15                    

gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg cgg        272
Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala Arg           
        20                  25                  30                        

gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc ctg        320
Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser Leu           
    35                  40                  45                            

tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc ctg        368
Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu           
50                  55                  60                  65            

ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag ggc        416
Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly           
                70                  75                  80                

gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg atc        464
Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile           
            85                  90                  95                    

ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc gag        512
Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu           
        100                 105                 110                       

agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag gtg        560
Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val           
    115                 120                 125                           

atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac atc        608
Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile           
130                 135                 140                 145           

gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct gct        656
Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala           
                150                 155                 160               

gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac cag        704
Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln           
            165                 170                 175                   

tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag gcc        752
Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu Ala           
        180                 185                 190                       

atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg ttt        800
Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe           
    195                 200                 205                           

tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg gcc        848
Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val Ala           
210                 215                 220                 225           

acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg gca        896
Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala           
                230                 235                 240               

gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt gga        944
Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly           
            245                 250                 255                   

cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg gtc        992
Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val           
        260                 265                 270                       

atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg ctg       1040
Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu           
    275                 280                 285                           

cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg gcg       1088
Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala           
290                 295                 300                 305           

gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca ctg       1136
Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu           
                310                 315                 320               

ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg ccg       1184
Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro           
            325                 330                 335                   

tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag acg       1232
Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr           
        340                 345                 350                       

ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg gta       1280
Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val           
    355                 360                 365                           

gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc tcg       1328
Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile Ser           
370                 375                 380                 385           

ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag cct       1376
Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln Pro           
                390                 395                 400               

gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc tgc       1424
Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys           
            405                 410                 415                   

gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt gtg       1472
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val           
        420                 425                 430                       

tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg gtg       1520
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val           
    435                 440                 445                           

gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg gtg       1568
Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg Val           
450                 455                 460                 465           

gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg aag       1616
Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg Lys           
                470                 475                 480               

gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg tac       1664
Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr           
            485                 490                 495                   

tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg ttt       1712
Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met Phe           
        500                 505                 510                       

gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc cgc       1760
Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg           
    515                 520                 525                           

gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag atc       1808
Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln Ile           
530                 535                 540                 545           

ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc tgc       1856
Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys           
                550                 555                 560               

ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg gag       1904
Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met Glu           
            565                 570                 575                   

ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc ttc       1952
Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe           
        580                 585                 590                       

gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct gcc       2000
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala           
    595                 600                 605                           

tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc acg       2048
Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile Thr           
610                 615                 620                 625           

ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc atc       2096
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile           
                630                 635                 640               

ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc gag       2144
Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg Glu           
            645                 650                 655                   

ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc gcc       2192
Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala           
        660                 665                 670                       

cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg gag       2240
Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu           
    675                 680                 685                           

aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga gtg       2288
Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val           
690                 695                 700                 705           

aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg ggc       2336
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly           
                710                 715                 720               

tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca gat       2384
Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp           
            725                 730                 735                   

gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc atc       2432
Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile           
        740                 745                 750                       

tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat gtt       2480
Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val           
    755                 760                 765                           

ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc gaa       2528
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu           
770                 775                 780                 785           

gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac ggc       2576
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly           
                790                 795                 800               

cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc atg       2624
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met           
            805                 810                 815                   

gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg ctc       2672
Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu           
        820                 825                 830                       

ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca gtg       2720
Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val           
    835                 840                 845                           

gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac atc       2768
Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His Ile           
850                 855                 860                 865           

aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac ccg       2816
Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro           
                870                 875                 880               

ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc acc       2864
Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro Thr           
            885                 890                 895                   

acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc ctc       2912
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu           
        900                 905                 910                       

aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg atg       2960
Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Met           
    915                 920                 925                           

aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac ttc       3008
Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His Phe           
930                 935                 940                 945           

ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc cca       3056
Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro           
                950                 955                 960               

ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct gtc       3104
Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro Val           
            965                 970                 975                   

atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg cac       3152
Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met His           
        980                 985                 990                       

gaa gaa atg agc cag aag tga gcgctgggaa cagagtggag tctccggtgt          3203
Glu Glu Met Ser Gln Lys                                                   
    995                                                                   

gtacctcaga ctgatggtgc ccatgtgttc gcctccgccc cccacccttg ccaccacact     3263

cgcccacttg cccaccgggt cccgccggat aaatgacagg cccgaggtca gaatggccat     3323

ccccgggccc cgtcctgggg tctctgtccc cacttccttc tggcctggga ggtctgtaat     3383

tcctgtctcc tggactctcc tgggaagttc cctgctctgc agctctggcc caggagctgc     3443

aggctgggag ggggcagcca agaagccgga gctggcagca tacccagaga tccggggccc     3503

ccccaccccc aaatcacgag tgcagctgga gcttgctccc ccttgttcgg aagctggacg     3563

ttcacttggt gactggtgcc tctgcactga cggaggactc tgggggtcct tcttaccggc     3623

tctgacctct ctcttcgtgc ctggtctggg actgggtcag ccctggggga tcagaagggg     3683

ccatctgggc ccagctgtgt acagcgaggg tgggcagccc cctccactcc actctgcttc     3743

cacaaagtcg gctcccgaga gctcgaggct gcttctgttt atatgtgcag ggcccgggcg     3803

ggtgaagggt cagagagacg gacacaagga gccggcagga gggcggagcg aggatgtcct     3863

ttcccgggag acaagtcggg aaagcctggc tggactgcct cagccccgcg cgcctcctgg     3923

actcagggtt ccccgtcctg agctcgggag atgttcagag tcacactgcc gcccggtctg     3983

ccacgcagag gtccaacttg ccacccgcgt ccctggtacc tgagaccacc gacatcctca     4043

ggttcctgac cgtggcgccc ttctacccag cccagtgtgc ggccgccgcg ctgtctgcac     4103

agctgggggc ctctgagcct ggtgggcttc ctggactctt ggcctcactc cttgccccct     4163

ccccacgaca cccatgagcc gaaaggatgt cactaaggat ggctgattcc ccaagggcac     4223

ccgctctccc tccctccctg ctggaggaac acgtcatatc agatgagagg aagatggcct     4283

ctgatggaca gaatttttct cttaactcag cttttgctac tttggcaaaa actagcgagg     4343

ggtagcagaa acctgcacca aggattgtcc ctatgtcttg gccactccta gagcgtgtgc     4403

agactgatga ttttatatgt aaatcaagac tcacatccct ttcctagtcc cccacatcca     4463

aagcccctca gcctgccttg cagaccaatg ggctccatgt tctgtagccc cctcccctac     4523

gcctcacccc tcctccctct cacaggttct gggcggccag tgagagaaac gcagtggggg     4583

aggcagggag tctggtgcct gcagagattc tctgcttctt tcctgggggg aggtggggag     4643

gtcttagcag gagcgggccc tgtacccacc tgctgacctg ctgtttggta gagaaataaa     4703

ggttgtgtga ctgggggaac ggaaaaaaaa aaaaaa                               4739


<210>  10
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Glu Glu Met Ser Gln Lys 
        995                 


<210>  11
<211>  4827
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(3305)

<400>  11
atcctggcgc gggccggggc cgccgccgcc actgccgtcg ggtaaggtcc cagcacggac       60

atggcctcgc gcggcgcccg cccgggcccg agtcccccgc gccccgcttt gtagcccccc      120

ggcggagagg cggcctcgac ggtgcggacg gcgcagacgg ccgggcgggc ggc atg         176
                                                           Met            
                                                           1              

gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc tcg        224
Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe Ser           
            5                   10                  15                    

gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg cgg        272
Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala Arg           
        20                  25                  30                        

gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc ctg        320
Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser Leu           
    35                  40                  45                            

tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc ctg        368
Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu           
50                  55                  60                  65            

ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag ggc        416
Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly           
                70                  75                  80                

gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg atc        464
Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile           
            85                  90                  95                    

ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc gag        512
Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu           
        100                 105                 110                       

agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag gtg        560
Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val           
    115                 120                 125                           

atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac atc        608
Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile           
130                 135                 140                 145           

gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct gct        656
Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala           
                150                 155                 160               

gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac cag        704
Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln           
            165                 170                 175                   

tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag gcc        752
Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu Ala           
        180                 185                 190                       

atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg ttt        800
Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe           
    195                 200                 205                           

tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg gcc        848
Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val Ala           
210                 215                 220                 225           

acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg gca        896
Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala           
                230                 235                 240               

gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt gga        944
Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly           
            245                 250                 255                   

cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg gtc        992
Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val           
        260                 265                 270                       

atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg ctg       1040
Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu           
    275                 280                 285                           

cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg gcg       1088
Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala           
290                 295                 300                 305           

gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca ctg       1136
Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu           
                310                 315                 320               

ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg ccg       1184
Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro           
            325                 330                 335                   

tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag acg       1232
Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr           
        340                 345                 350                       

ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg gta       1280
Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val           
    355                 360                 365                           

gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc tcg       1328
Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile Ser           
370                 375                 380                 385           

ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag cct       1376
Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln Pro           
                390                 395                 400               

gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc tgc       1424
Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys           
            405                 410                 415                   

gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt gtg       1472
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val           
        420                 425                 430                       

tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg gtg       1520
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val           
    435                 440                 445                           

gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg gtg       1568
Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg Val           
450                 455                 460                 465           

gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg aag       1616
Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg Lys           
                470                 475                 480               

gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg tac       1664
Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr           
            485                 490                 495                   

tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg ttt       1712
Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met Phe           
        500                 505                 510                       

gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc cgc       1760
Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg           
    515                 520                 525                           

gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag atc       1808
Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln Ile           
530                 535                 540                 545           

ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc tgc       1856
Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys           
                550                 555                 560               

ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg gag       1904
Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met Glu           
            565                 570                 575                   

ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc ttc       1952
Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe           
        580                 585                 590                       

gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct gcc       2000
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala           
    595                 600                 605                           

tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc acg       2048
Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile Thr           
610                 615                 620                 625           

ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc atc       2096
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile           
                630                 635                 640               

ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc gag       2144
Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg Glu           
            645                 650                 655                   

ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc gcc       2192
Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala           
        660                 665                 670                       

cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg gag       2240
Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu           
    675                 680                 685                           

aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga gtg       2288
Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val           
690                 695                 700                 705           

aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg ggc       2336
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly           
                710                 715                 720               

tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca gat       2384
Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp           
            725                 730                 735                   

gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc atc       2432
Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile           
        740                 745                 750                       

tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat gtt       2480
Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val           
    755                 760                 765                           

ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc gaa       2528
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu           
770                 775                 780                 785           

gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac ggc       2576
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly           
                790                 795                 800               

cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc atg       2624
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met           
            805                 810                 815                   

gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg ctc       2672
Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu           
        820                 825                 830                       

ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca gtg       2720
Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val           
    835                 840                 845                           

gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac atc       2768
Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His Ile           
850                 855                 860                 865           

aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac ccg       2816
Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro           
                870                 875                 880               

ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc acc       2864
Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro Thr           
            885                 890                 895                   

acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc ctc       2912
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu           
        900                 905                 910                       

aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg atg       2960
Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Met           
    915                 920                 925                           

aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac ttc       3008
Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His Phe           
930                 935                 940                 945           

ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc cca       3056
Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro           
                950                 955                 960               

ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct gtc       3104
Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro Val           
            965                 970                 975                   

atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg cac       3152
Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met His           
        980                 985                 990                       

gcc tgt ctt tat cca ggc ctt  ctc agg aca gtc tcg  cag gcc tgg agt     3200
Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp Ser         
    995                 1000                 1005                         

agg  cag ccg ctg acc acc  tct tgg acc cca gac  cac acc gga aga        3245
Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly Arg            
1010                 1015                 1020                            

aat  gag cca gaa gtg agc  gct ggg aac aga gtg  gag tct ccg gtg        3290
Asn  Glu Pro Glu Val Ser  Ala Gly Asn Arg Val  Glu Ser Pro Val            
1025                 1030                 1035                            

tgt  acc tca gac tga tggtgcccat gtgttcgcct ccgcccccca cccttgccac      3345
Cys  Thr Ser Asp                                                          
1040                                                                      

cacactcgcc cacttgccca ccgggtcccg ccggataaat gacaggcccg aggtcagaat     3405

ggccatcccc gggccccgtc ctggggtctc tgtccccact tccttctggc ctgggaggtc     3465

tgtaattcct gtctcctgga ctctcctggg aagttccctg ctctgcagct ctggcccagg     3525

agctgcaggc tgggaggggg cagccaagaa gccggagctg gcagcatacc cagagatccg     3585

gggccccccc acccccaaat cacgagtgca gctggagctt gctccccctt gttcggaagc     3645

tggacgttca cttggtgact ggtgcctctg cactgacgga ggactctggg ggtccttctt     3705

accggctctg acctctctct tcgtgcctgg tctgggactg ggtcagccct gggggatcag     3765

aaggggccat ctgggcccag ctgtgtacag cgagggtggg cagccccctc cactccactc     3825

tgcttccaca aagtcggctc ccgagagctc gaggctgctt ctgtttatat gtgcagggcc     3885

cgggcgggtg aagggtcaga gagacggaca caaggagccg gcaggagggc ggagcgagga     3945

tgtcctttcc cgggagacaa gtcgggaaag cctggctgga ctgcctcagc cccgcgcgcc     4005

tcctggactc agggttcccc gtcctgagct cgggagatgt tcagagtcac actgccgccc     4065

ggtctgccac gcagaggtcc aacttgccac ccgcgtccct ggtacctgag accaccgaca     4125

tcctcaggtt cctgaccgtg gcgcccttct acccagccca gtgtgcggcc gccgcgctgt     4185

ctgcacagct gggggcctct gagcctggtg ggcttcctgg actcttggcc tcactccttg     4245

ccccctcccc acgacaccca tgagccgaaa ggatgtcact aaggatggct gattccccaa     4305

gggcacccgc tctccctccc tccctgctgg aggaacacgt catatcagat gagaggaaga     4365

tggcctctga tggacagaat ttttctctta actcagcttt tgctactttg gcaaaaacta     4425

gcgaggggta gcagaaacct gcaccaagga ttgtccctat gtcttggcca ctcctagagc     4485

gtgtgcagac tgatgatttt atatgtaaat caagactcac atccctttcc tagtccccca     4545

catccaaagc ccctcagcct gccttgcaga ccaatgggct ccatgttctg tagccccctc     4605

ccctacgcct cacccctcct ccctctcaca ggttctgggc ggccagtgag agaaacgcag     4665

tgggggaggc agggagtctg gtgcctgcag agattctctg cttctttcct ggggggaggt     4725

ggggaggtct tagcaggagc gggccctgta cccacctgct gacctgctgt ttggtagaga     4785

aataaaggtt gtgtgactgg gggaacggaa aaaaaaaaaa aa                        4827


<210>  12
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Arg Asn  Glu Pro Glu Val Ser  Ala Gly Asn Arg Val  Glu Ser Pro 
    1025                 1030                 1035             


Val Cys  Thr Ser Asp 
    1040             


<210>  13
<211>  4885
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(3308)

<400>  13
atcctggcgc gggccggggc cgccgccgcc actgccgtcg ggtaaggtcc cagcacggac       60

atggcctcgc gcggcgcccg cccgggcccg agtcccccgc gccccgcttt gtagcccccc      120

ggcggagagg cggcctcgac ggtgcggacg gcgcagacgg ccgggcgggc ggc atg         176
                                                           Met            
                                                           1              

gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc tcg        224
Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe Ser           
            5                   10                  15                    

gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg cgg        272
Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala Arg           
        20                  25                  30                        

gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc ctg        320
Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser Leu           
    35                  40                  45                            

tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc ctg        368
Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu           
50                  55                  60                  65            

ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag ggc        416
Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly           
                70                  75                  80                

gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg atc        464
Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile           
            85                  90                  95                    

ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc gag        512
Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu           
        100                 105                 110                       

agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag gtg        560
Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val           
    115                 120                 125                           

atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac atc        608
Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile           
130                 135                 140                 145           

gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct gct        656
Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala           
                150                 155                 160               

gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac cag        704
Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln           
            165                 170                 175                   

tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag gcc        752
Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu Ala           
        180                 185                 190                       

atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg ttt        800
Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe           
    195                 200                 205                           

tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg gcc        848
Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val Ala           
210                 215                 220                 225           

acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg gca        896
Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala           
                230                 235                 240               

gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt gga        944
Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly           
            245                 250                 255                   

cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg gtc        992
Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val           
        260                 265                 270                       

atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg ctg       1040
Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu           
    275                 280                 285                           

cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg gcg       1088
Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala           
290                 295                 300                 305           

gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca ctg       1136
Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu           
                310                 315                 320               

ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg ccg       1184
Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro           
            325                 330                 335                   

tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag acg       1232
Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr           
        340                 345                 350                       

ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg gta       1280
Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val           
    355                 360                 365                           

gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc tcg       1328
Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile Ser           
370                 375                 380                 385           

ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag cct       1376
Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln Pro           
                390                 395                 400               

gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc tgc       1424
Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys           
            405                 410                 415                   

gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt gtg       1472
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val           
        420                 425                 430                       

tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg gtg       1520
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val           
    435                 440                 445                           

gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg gtg       1568
Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg Val           
450                 455                 460                 465           

gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg aag       1616
Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg Lys           
                470                 475                 480               

gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg tac       1664
Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr           
            485                 490                 495                   

tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg ttt       1712
Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met Phe           
        500                 505                 510                       

gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc cgc       1760
Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg           
    515                 520                 525                           

gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag atc       1808
Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln Ile           
530                 535                 540                 545           

ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc tgc       1856
Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys           
                550                 555                 560               

ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg gag       1904
Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met Glu           
            565                 570                 575                   

ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc ttc       1952
Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe           
        580                 585                 590                       

gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct gcc       2000
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala           
    595                 600                 605                           

tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc acg       2048
Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile Thr           
610                 615                 620                 625           

ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc atc       2096
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile           
                630                 635                 640               

ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc gag       2144
Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg Glu           
            645                 650                 655                   

ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc gcc       2192
Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala           
        660                 665                 670                       

cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg gag       2240
Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu           
    675                 680                 685                           

aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga gtg       2288
Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val           
690                 695                 700                 705           

aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg ggc       2336
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly           
                710                 715                 720               

tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca gat       2384
Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp           
            725                 730                 735                   

gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc atc       2432
Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile           
        740                 745                 750                       

tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat gtt       2480
Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val           
    755                 760                 765                           

ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc gaa       2528
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu           
770                 775                 780                 785           

gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac ggc       2576
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly           
                790                 795                 800               

cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc atg       2624
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met           
            805                 810                 815                   

gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg ctc       2672
Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu           
        820                 825                 830                       

ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca gtg       2720
Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val           
    835                 840                 845                           

gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac atc       2768
Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His Ile           
850                 855                 860                 865           

aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac ccg       2816
Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro           
                870                 875                 880               

ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc acc       2864
Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro Thr           
            885                 890                 895                   

acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc ctc       2912
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu           
        900                 905                 910                       

aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg atg       2960
Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Met           
    915                 920                 925                           

aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac ttc       3008
Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His Phe           
930                 935                 940                 945           

ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc cca       3056
Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro           
                950                 955                 960               

ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct gtc       3104
Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro Val           
            965                 970                 975                   

atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg cac       3152
Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met His           
        980                 985                 990                       

gcc tgt ctt tat cca ggc ctt  ctc agg aca gtc tcg  cag gcc tgg agt     3200
Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp Ser         
    995                 1000                 1005                         

agg  cag ccg ctg acc acc  tct tgg acc cca gac  cac acc ggg gcc        3245
Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly Ala            
1010                 1015                 1020                            

agg  gac aca gca tcg tct  cgc tgt cag agc tgc  tca gag agg gag        3290
Arg  Asp Thr Ala Ser Ser  Arg Cys Gln Ser Cys  Ser Glu Arg Glu            
1025                 1030                 1035                            

gaa  gca ggg aag aaa tga gccagaagtg agcgctggga acagagtgga             3338
Glu  Ala Gly Lys Lys                                                      
1040                                                                      

gtctccggtg tgtacctcag actgatggtg cccatgtgtt cgcctccgcc ccccaccctt     3398

gccaccacac tcgcccactt gcccaccggg tcccgccgga taaatgacag gcccgaggtc     3458

agaatggcca tccccgggcc ccgtcctggg gtctctgtcc ccacttcctt ctggcctggg     3518

aggtctgtaa ttcctgtctc ctggactctc ctgggaagtt ccctgctctg cagctctggc     3578

ccaggagctg caggctggga gggggcagcc aagaagccgg agctggcagc atacccagag     3638

atccggggcc cccccacccc caaatcacga gtgcagctgg agcttgctcc cccttgttcg     3698

gaagctggac gttcacttgg tgactggtgc ctctgcactg acggaggact ctgggggtcc     3758

ttcttaccgg ctctgacctc tctcttcgtg cctggtctgg gactgggtca gccctggggg     3818

atcagaaggg gccatctggg cccagctgtg tacagcgagg gtgggcagcc ccctccactc     3878

cactctgctt ccacaaagtc ggctcccgag agctcgaggc tgcttctgtt tatatgtgca     3938

gggcccgggc gggtgaaggg tcagagagac ggacacaagg agccggcagg agggcggagc     3998

gaggatgtcc tttcccggga gacaagtcgg gaaagcctgg ctggactgcc tcagccccgc     4058

gcgcctcctg gactcagggt tccccgtcct gagctcggga gatgttcaga gtcacactgc     4118

cgcccggtct gccacgcaga ggtccaactt gccacccgcg tccctggtac ctgagaccac     4178

cgacatcctc aggttcctga ccgtggcgcc cttctaccca gcccagtgtg cggccgccgc     4238

gctgtctgca cagctggggg cctctgagcc tggtgggctt cctggactct tggcctcact     4298

ccttgccccc tccccacgac acccatgagc cgaaaggatg tcactaagga tggctgattc     4358

cccaagggca cccgctctcc ctccctccct gctggaggaa cacgtcatat cagatgagag     4418

gaagatggcc tctgatggac agaatttttc tcttaactca gcttttgcta ctttggcaaa     4478

aactagcgag gggtagcaga aacctgcacc aaggattgtc cctatgtctt ggccactcct     4538

agagcgtgtg cagactgatg attttatatg taaatcaaga ctcacatccc tttcctagtc     4598

ccccacatcc aaagcccctc agcctgcctt gcagaccaat gggctccatg ttctgtagcc     4658

ccctccccta cgcctcaccc ctcctccctc tcacaggttc tgggcggcca gtgagagaaa     4718

cgcagtgggg gaggcaggga gtctggtgcc tgcagagatt ctctgcttct ttcctggggg     4778

gaggtgggga ggtcttagca ggagcgggcc ctgtacccac ctgctgacct gctgtttggt     4838

agagaaataa aggttgtgtg actgggggaa cggaaaaaaa aaaaaaa                   4885


<210>  14
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Ala Arg  Asp Thr Ala Ser Ser  Arg Cys Gln Ser Cys  Ser Glu Arg 
    1025                 1030                 1035             


Glu Glu  Ala Gly Lys Lys 
    1040                 


<210>  15
<211>  4898
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(3332)

<400>  15
atcctggcgc gggccggggc cgccgccgcc actgccgtcg ggtaaggtcc cagcacggac       60

atggcctcgc gcggcgcccg cccgggcccg agtcccccgc gccccgcttt gtagcccccc      120

ggcggagagg cggcctcgac ggtgcggacg gcgcagacgg ccgggcgggc ggc atg         176
                                                           Met            
                                                           1              

gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc tcg        224
Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe Ser           
            5                   10                  15                    

gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg cgg        272
Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala Arg           
        20                  25                  30                        

gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc ctg        320
Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser Leu           
    35                  40                  45                            

tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc ctg        368
Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu           
50                  55                  60                  65            

ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag ggc        416
Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly           
                70                  75                  80                

gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg atc        464
Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile           
            85                  90                  95                    

ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc gag        512
Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu           
        100                 105                 110                       

agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag gtg        560
Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val           
    115                 120                 125                           

atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac atc        608
Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile           
130                 135                 140                 145           

gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct gct        656
Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala           
                150                 155                 160               

gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac cag        704
Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln           
            165                 170                 175                   

tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag gcc        752
Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu Ala           
        180                 185                 190                       

atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg ttt        800
Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe           
    195                 200                 205                           

tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg gcc        848
Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val Ala           
210                 215                 220                 225           

acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg gca        896
Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala           
                230                 235                 240               

gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt gga        944
Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly           
            245                 250                 255                   

cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg gtc        992
Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val           
        260                 265                 270                       

atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg ctg       1040
Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu           
    275                 280                 285                           

cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg gcg       1088
Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala           
290                 295                 300                 305           

gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca ctg       1136
Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu           
                310                 315                 320               

ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg ccg       1184
Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro           
            325                 330                 335                   

tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag acg       1232
Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr           
        340                 345                 350                       

ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg gta       1280
Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val           
    355                 360                 365                           

gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc tcg       1328
Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile Ser           
370                 375                 380                 385           

ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag cct       1376
Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln Pro           
                390                 395                 400               

gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc tgc       1424
Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys           
            405                 410                 415                   

gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt gtg       1472
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val           
        420                 425                 430                       

tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg gtg       1520
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val           
    435                 440                 445                           

gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg gtg       1568
Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg Val           
450                 455                 460                 465           

gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg aag       1616
Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg Lys           
                470                 475                 480               

gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg tac       1664
Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr           
            485                 490                 495                   

tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg ttt       1712
Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met Phe           
        500                 505                 510                       

gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc cgc       1760
Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg           
    515                 520                 525                           

gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag atc       1808
Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln Ile           
530                 535                 540                 545           

ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc tgc       1856
Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys           
                550                 555                 560               

ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg gag       1904
Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met Glu           
            565                 570                 575                   

ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc ttc       1952
Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe           
        580                 585                 590                       

gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct gcc       2000
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala           
    595                 600                 605                           

tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc acg       2048
Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile Thr           
610                 615                 620                 625           

ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc atc       2096
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile           
                630                 635                 640               

ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc gag       2144
Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg Glu           
            645                 650                 655                   

ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc gcc       2192
Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala           
        660                 665                 670                       

cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg gag       2240
Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu           
    675                 680                 685                           

aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga gtg       2288
Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val           
690                 695                 700                 705           

aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg ggc       2336
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly           
                710                 715                 720               

tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca gat       2384
Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp           
            725                 730                 735                   

gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc atc       2432
Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile           
        740                 745                 750                       

tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat gtt       2480
Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val           
    755                 760                 765                           

ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc gaa       2528
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu           
770                 775                 780                 785           

gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac ggc       2576
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly           
                790                 795                 800               

cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc atg       2624
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met           
            805                 810                 815                   

gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg ctc       2672
Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu           
        820                 825                 830                       

ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca gtg       2720
Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val           
    835                 840                 845                           

gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac atc       2768
Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His Ile           
850                 855                 860                 865           

aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac ccg       2816
Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro           
                870                 875                 880               

ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc acc       2864
Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro Thr           
            885                 890                 895                   

acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc ctc       2912
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu           
        900                 905                 910                       

aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg atg       2960
Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Met           
    915                 920                 925                           

aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac ttc       3008
Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His Phe           
930                 935                 940                 945           

ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc cca       3056
Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro           
                950                 955                 960               

ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct gtc       3104
Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro Val           
            965                 970                 975                   

atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg cac       3152
Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met His           
        980                 985                 990                       

gcc tgt ctt tat cca ggc ctt  ctc agg aca gtc tcg  cag gcc tgg agt     3200
Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp Ser         
    995                 1000                 1005                         

agg  cag ccg ctg acc acc  tct tgg acc cca gac  cac acc ggg ttg        3245
Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly Leu            
1010                 1015                 1020                            

gcc  tct ttg ggc cag gga  cac agc atc gtc tcg  ctg tca gag ctg        3290
Ala  Ser Leu Gly Gln Gly  His Ser Ile Val Ser  Leu Ser Glu Leu            
1025                 1030                 1035                            

ctc  aga gag gga gga agc  agg gaa gaa atg agc  cag aag tga            3332
Leu  Arg Glu Gly Gly Ser  Arg Glu Glu Met Ser  Gln Lys                    
1040                 1045                 1050                            

gcgctgggaa cagagtggag tctccggtgt gtacctcaga ctgatggtgc ccatgtgttc     3392

gcctccgccc cccacccttg ccaccacact cgcccacttg cccaccgggt cccgccggat     3452

aaatgacagg cccgaggtca gaatggccat ccccgggccc cgtcctgggg tctctgtccc     3512

cacttccttc tggcctggga ggtctgtaat tcctgtctcc tggactctcc tgggaagttc     3572

cctgctctgc agctctggcc caggagctgc aggctgggag ggggcagcca agaagccgga     3632

gctggcagca tacccagaga tccggggccc ccccaccccc aaatcacgag tgcagctgga     3692

gcttgctccc ccttgttcgg aagctggacg ttcacttggt gactggtgcc tctgcactga     3752

cggaggactc tgggggtcct tcttaccggc tctgacctct ctcttcgtgc ctggtctggg     3812

actgggtcag ccctggggga tcagaagggg ccatctgggc ccagctgtgt acagcgaggg     3872

tgggcagccc cctccactcc actctgcttc cacaaagtcg gctcccgaga gctcgaggct     3932

gcttctgttt atatgtgcag ggcccgggcg ggtgaagggt cagagagacg gacacaagga     3992

gccggcagga gggcggagcg aggatgtcct ttcccgggag acaagtcggg aaagcctggc     4052

tggactgcct cagccccgcg cgcctcctgg actcagggtt ccccgtcctg agctcgggag     4112

atgttcagag tcacactgcc gcccggtctg ccacgcagag gtccaacttg ccacccgcgt     4172

ccctggtacc tgagaccacc gacatcctca ggttcctgac cgtggcgccc ttctacccag     4232

cccagtgtgc ggccgccgcg ctgtctgcac agctgggggc ctctgagcct ggtgggcttc     4292

ctggactctt ggcctcactc cttgccccct ccccacgaca cccatgagcc gaaaggatgt     4352

cactaaggat ggctgattcc ccaagggcac ccgctctccc tccctccctg ctggaggaac     4412

acgtcatatc agatgagagg aagatggcct ctgatggaca gaatttttct cttaactcag     4472

cttttgctac tttggcaaaa actagcgagg ggtagcagaa acctgcacca aggattgtcc     4532

ctatgtcttg gccactccta gagcgtgtgc agactgatga ttttatatgt aaatcaagac     4592

tcacatccct ttcctagtcc cccacatcca aagcccctca gcctgccttg cagaccaatg     4652

ggctccatgt tctgtagccc cctcccctac gcctcacccc tcctccctct cacaggttct     4712

gggcggccag tgagagaaac gcagtggggg aggcagggag tctggtgcct gcagagattc     4772

tctgcttctt tcctgggggg aggtggggag gtcttagcag gagcgggccc tgtacccacc     4832

tgctgacctg ctgtttggta gagaaataaa ggttgtgtga ctgggggaac ggaaaaaaaa     4892

aaaaaa                                                                4898


<210>  16
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Gly Gln Gly  His Ser Ile Val Ser  Leu Ser Glu 
    1025                 1030                 1035             


Leu Leu  Arg Glu Gly Gly Ser  Arg Glu Glu Met Ser  Gln Lys 
    1040                 1045                 1050         


<210>  17
<211>  4736
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(3170)

<400>  17
atcctggcgc gggccggggc cgccgccgcc actgccgtcg ggtaaggtcc cagcacggac       60

atggcctcgc gcggcgcccg cccgggcccg agtcccccgc gccccgcttt gtagcccccc      120

ggcggagagg cggcctcgac ggtgcggacg gcgcagacgg ccgggcgggc ggc atg         176
                                                           Met            
                                                           1              

gag gcg gcg cat ctg ctc ccg gcc gcc gac gtg ctg cgc cac ttc tcg        224
Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe Ser           
            5                   10                  15                    

gtg aca gcc gag ggc ggc ctg agc ccg gcg cag gtg acc ggc gcg cgg        272
Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala Arg           
        20                  25                  30                        

gag cgc tac ggc ccc aac gag ctc ccg agt gag gaa ggg aag tcc ctg        320
Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser Leu           
    35                  40                  45                            

tgg gag ctg gtg ctg gaa cag ttt gag gac ctc ctg gtg cgc atc ctg        368
Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu           
50                  55                  60                  65            

ctg ctg gct gcc ctt gtc tcc ttt gtc ctg gcc tgg ttc gag gag ggc        416
Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu Gly           
                70                  75                  80                

gag gag acc acg acc gcc ttc gtg gag ccc ctg gtc atc atg ctg atc        464
Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu Ile           
            85                  90                  95                    

ctc gtg gcc aac gcc att gtg ggc gtg tgg cag gaa cgc aac gcc gag        512
Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu           
        100                 105                 110                       

agt gcc atc gag gcc ctg aag gag tat gag cct gag atg ggc aag gtg        560
Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val           
    115                 120                 125                           

atc cgc tcg gac cgc aag ggc gtg cag agg atc cgt gcc cgg gac atc        608
Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp Ile           
130                 135                 140                 145           

gtc cca ggg gac att gta gaa gtg gca gtg ggg gac aaa gtg cct gct        656
Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala           
                150                 155                 160               

gac ctc cgc ctc atc gag atc aag tcc acc acg ctg cga gtg gac cag        704
Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp Gln           
            165                 170                 175                   

tcc atc ctg acg ggt gaa tct gtg tcc gtg acc aag cac aca gag gcc        752
Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu Ala           
        180                 185                 190                       

atc cca gac ccc aga gct gtg aac cag gac aag aag aac atg ctg ttt        800
Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe           
    195                 200                 205                           

tct ggc acc aat atc aca tcg ggc aaa gcg gtg ggt gtg gcc gtg gcc        848
Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val Ala           
210                 215                 220                 225           

acc ggc ctg cac acg gag ctg ggc aag atc cgg agc cag atg gcg gca        896
Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala Ala           
                230                 235                 240               

gtc gag ccc gag cgg acg ccg ctg cag cgc aag ctg gac gag ttt gga        944
Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe Gly           
            245                 250                 255                   

cgg cag ctg tcc cac gcc atc tct gtg atc tgc gtg gcc gtg tgg gtc        992
Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp Val           
        260                 265                 270                       

atc aac atc ggc cac ttc gcc gac ccg gcc cac ggt ggc tcc tgg ctg       1040
Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp Leu           
    275                 280                 285                           

cgt ggc gct gtc tac tac ttc aag atc gcc gtg gcc ctg gcg gtg gcg       1088
Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala           
290                 295                 300                 305           

gcc atc ccc gag ggc ctc ccg gct gtc atc act aca tgc ctg gca ctg       1136
Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu           
                310                 315                 320               

ggc acg cgg cgc atg gca cgc aag aac gcc atc gtg cga agc ctg ccg       1184
Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu Pro           
            325                 330                 335                   

tcc gtg gag acc ctg ggc tgc acc tca gtc atc tgc tcc gac aag acg       1232
Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr           
        340                 345                 350                       

ggc acg ctc acc acc aat cag atg tct gtc tgc cgg atg ttc gtg gta       1280
Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val Val           
    355                 360                 365                           

gcc gag gcc gat gcg ggc tcc tgc ctt ttg cac gag ttc acc atc tcg       1328
Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile Ser           
370                 375                 380                 385           

ggt acc acg tat acc ccc gag ggc gaa gtg cgg cag ggg gat cag cct       1376
Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln Pro           
                390                 395                 400               

gtg cgc tgc ggc cag ttc gac ggg ctg gtg gag ctg gcg acc atc tgc       1424
Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile Cys           
            405                 410                 415                   

gcc ctg tgc aac gac tcg gct ctg gac tac aac gag gcc aag ggt gtg       1472
Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly Val           
        420                 425                 430                       

tat gag aag gtg gga gag gcc acg gag aca gct ctg act tgc ctg gtg       1520
Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val           
    435                 440                 445                           

gag aag atg aac gtg ttc gac acc gac ctg cag gct ctg tcc cgg gtg       1568
Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg Val           
450                 455                 460                 465           

gag cga gct ggc gcc tgt aac acg gtc atc aag cag ctg atg cgg aag       1616
Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg Lys           
                470                 475                 480               

gag ttc acc ctg gag ttc tcc cga gac cgg aaa tcc atg tcc gtg tac       1664
Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr           
            485                 490                 495                   

tgc acg ccc acc cgc cct cac cct act ggc cag ggc agc aag atg ttt       1712
Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met Phe           
        500                 505                 510                       

gtg aag ggg gct cct gag agt gtg atc gag cgc tgt agc tca gtc cgc       1760
Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val Arg           
    515                 520                 525                           

gtg ggg agc cgc aca gca ccc ctg acc ccc acc tcc agg gag cag atc       1808
Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln Ile           
530                 535                 540                 545           

ctg gca aag atc cgg gat tgg ggc tca ggc tca gac acg ctg cgc tgc       1856
Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys           
                550                 555                 560               

ctg gca ctg gcc acc cgg gac gcg ccc cca agg aag gag gac atg gag       1904
Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met Glu           
            565                 570                 575                   

ctg gac gac tgc agc aag ttt gtg cag tac gag acg gac ctg acc ttc       1952
Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr Phe           
        580                 585                 590                       

gtg ggc tgc gta ggc atg ctg gac ccg ccg cga cct gag gtg gct gcc       2000
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala Ala           
    595                 600                 605                           

tgc atc aca cgc tgc tac cag gcg ggc atc cgc gtg gtc atg atc acg       2048
Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile Thr           
610                 615                 620                 625           

ggg gat aac aaa ggc act gcc gtg gcc atc tgc cgc agg ctt ggc atc       2096
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly Ile           
                630                 635                 640               

ttt ggg gac acg gaa gac gtg gcg ggc aag gcc tac acg ggc cgc gag       2144
Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg Glu           
            645                 650                 655                   

ttt gat gac ctc agc ccc gag cag cag cgc cag gcc tgc cgc acc gcc       2192
Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr Ala           
        660                 665                 670                       

cgc tgc ttc gcc cgc gtg gag ccc gca cac aag tcc cgc atc gtg gag       2240
Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val Glu           
    675                 680                 685                           

aac ctg cag tcc ttt aac gag atc act gct atg act ggc gat gga gtg       2288
Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly Val           
690                 695                 700                 705           

aac gac gca cca gcc ctg aag aaa gca gag atc ggc atc gcc atg ggc       2336
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly           
                710                 715                 720               

tca ggc acg gcc gtg gcc aag tcg gcg gca gag atg gtg ctg tca gat       2384
Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser Asp           
            725                 730                 735                   

gac aac ttt gcc tcc atc gtg gct gcg gtg gag gag ggc cgg gcc atc       2432
Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile           
        740                 745                 750                       

tac agc aac atg aag caa ttc atc cgc tac ctc atc tcc tcc aat gtt       2480
Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val           
    755                 760                 765                           

ggc gag gtc gtc tgc atc ttc ctc acg gca att ctg ggc ctg ccc gaa       2528
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro Glu           
770                 775                 780                 785           

gcc ctg atc cct gtg cag ctg ctc tgg gtg aac ctg gtg aca gac ggc       2576
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly           
                790                 795                 800               

cta cct gcc acg gct ctg ggc ttc aac ccg cca gac ctg gac atc atg       2624
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met           
            805                 810                 815                   

gag aag ctg ccc cgg agc ccc cga gaa gcc ctc atc agt ggc tgg ctc       2672
Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp Leu           
        820                 825                 830                       

ttc ttc cga tac ctg gct atc gga gtg tac gta ggc ctg gcc aca gtg       2720
Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr Val           
    835                 840                 845                           

gct gcc gcc acc tgg tgg ttt gtg tat gac gcc gag gga cct cac atc       2768
Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His Ile           
850                 855                 860                 865           

aac ttc tac cag ctg agg aac ttc ctg aag tgc tcc gaa gac aac ccg       2816
Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn Pro           
                870                 875                 880               

ctc ttt gcc ggc atc gac tgt gag gtg ttc gag tca cgc ttc ccc acc       2864
Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro Thr           
            885                 890                 895                   

acc atg gcc ttg tcc gtg ctc gtg acc att gaa atg tgc aat gcc ctc       2912
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu           
        900                 905                 910                       

aac agc gtc tcg gag aac cag tcg ctg ctg cgg atg ccg ccc tgg atg       2960
Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Met           
    915                 920                 925                           

aac ccc tgg ctg ctg gtg gct gtg gcc atg tcc atg gcc ctg cac ttc       3008
Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His Phe           
930                 935                 940                 945           

ctc atc ctg ctc gtg ccg ccc ctg cct ctc att ttc cag gtg acc cca       3056
Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr Pro           
                950                 955                 960               

ctg agc ggg cgc cag tgg gtg gtg gtg ctc cag ata tct ctg cct gtc       3104
Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro Val           
            965                 970                 975                   

atc ctg ctg gat gag gcc ctc aag tac ctg tcc cgg aac cac atg cac       3152
Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met His           
        980                 985                 990                       

gaa atg agc cag aag tga gcgctgggaa cagagtggag tctccggtgt              3200
Glu Met Ser Gln Lys                                                       
    995                                                                   

gtacctcaga ctgatggtgc ccatgtgttc gcctccgccc cccacccttg ccaccacact     3260

cgcccacttg cccaccgggt cccgccggat aaatgacagg cccgaggtca gaatggccat     3320

ccccgggccc cgtcctgggg tctctgtccc cacttccttc tggcctggga ggtctgtaat     3380

tcctgtctcc tggactctcc tgggaagttc cctgctctgc agctctggcc caggagctgc     3440

aggctgggag ggggcagcca agaagccgga gctggcagca tacccagaga tccggggccc     3500

ccccaccccc aaatcacgag tgcagctgga gcttgctccc ccttgttcgg aagctggacg     3560

ttcacttggt gactggtgcc tctgcactga cggaggactc tgggggtcct tcttaccggc     3620

tctgacctct ctcttcgtgc ctggtctggg actgggtcag ccctggggga tcagaagggg     3680

ccatctgggc ccagctgtgt acagcgaggg tgggcagccc cctccactcc actctgcttc     3740

cacaaagtcg gctcccgaga gctcgaggct gcttctgttt atatgtgcag ggcccgggcg     3800

ggtgaagggt cagagagacg gacacaagga gccggcagga gggcggagcg aggatgtcct     3860

ttcccgggag acaagtcggg aaagcctggc tggactgcct cagccccgcg cgcctcctgg     3920

actcagggtt ccccgtcctg agctcgggag atgttcagag tcacactgcc gcccggtctg     3980

ccacgcagag gtccaacttg ccacccgcgt ccctggtacc tgagaccacc gacatcctca     4040

ggttcctgac cgtggcgccc ttctacccag cccagtgtgc ggccgccgcg ctgtctgcac     4100

agctgggggc ctctgagcct ggtgggcttc ctggactctt ggcctcactc cttgccccct     4160

ccccacgaca cccatgagcc gaaaggatgt cactaaggat ggctgattcc ccaagggcac     4220

ccgctctccc tccctccctg ctggaggaac acgtcatatc agatgagagg aagatggcct     4280

ctgatggaca gaatttttct cttaactcag cttttgctac tttggcaaaa actagcgagg     4340

ggtagcagaa acctgcacca aggattgtcc ctatgtcttg gccactccta gagcgtgtgc     4400

agactgatga ttttatatgt aaatcaagac tcacatccct ttcctagtcc cccacatcca     4460

aagcccctca gcctgccttg cagaccaatg ggctccatgt tctgtagccc cctcccctac     4520

gcctcacccc tcctccctct cacaggttct gggcggccag tgagagaaac gcagtggggg     4580

aggcagggag tctggtgcct gcagagattc tctgcttctt tcctgggggg aggtggggag     4640

gtcttagcag gagcgggccc tgtacccacc tgctgacctg ctgtttggta gagaaataaa     4700

ggttgtgtga ctgggggaac ggaaaaaaaa aaaaaa                               4736


<210>  18
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Glu Met Ser Gln Lys 
        995             



