                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Methods and uses relating to the identification and profiling of 
       compounds for use in the treatment or prevention of pain

<130>  DE2011/129

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1684
<212>  DNA
<213>  Mus musculus

<400>  1
gctttaatgc agcaaggaac aaagaactca catgggctta gaggtgaaca cacaaccagg       60

gctgcagtta gaactcttcc aagtgccaaa gcccaccggc gaagacatct gctggccagg      120

acttgttgca gacagagggt ctttctcagg tgacactagc ctgctttacc aagactgctg      180

acatgggtac tagacttgag gcaactgagc aaagcaacca cagaactcag aggaatgaca      240

ttcagctgga aaatgcaaag gctgctggga aaatgggcat cagtgttgat ctggaagcca      300

aatatgctaa gctgggtcta aatctcggag caatcacttt tggagagaag gataggaaga      360

aaatgaagaa ttctcacctc agaaaacagg agaatgcaaa catctctcta gctgtatgtg      420

ctctcctgaa ttcgggaggt ggagcaatca aggttaaaat tgaaaatgaa aattatagtc      480

tcactaggga tggcctggga ctagatttgg aagcctctct ttgtaaatgt ctgccctttg      540

tccagtggca cctggacttc acggagagcg aaggctacat ttatatctac gtgaaatcgt      600

ggagccaaga aatctttggg ctgcctattg gcaccctaag aaccaatttg tatgtaagga      660

gcatgtcatc ttctgtacaa gtgagcgccg ctgctgccct ggaatttctc caggacctgg      720

aggaaactgg agggagaccc tgtgtcagac cagagttgcc tgcaagcata gccttccctg      780

aagtggaagg agaatggcac ctggaggatt tggctgctgc attgtttaac aggacagaat      840

ttcagtacga ggaaactttc ccctttacca gatccagata tgttgaagtt acattgcttt      900

cagcgaaacg cctgcgaaaa cgcatcaaag agctcctccc tcaaactgtt tctgcttttg      960

caaacacgga tgggggattt ttgttcattg gtttggatgg caaaacccag caaattattg     1020

gttttgaagc agagaagagc gatctcgtgc ttctagagag tgaaatagaa aagcacatcc     1080

ggcagctgcc tgtcactcac ttctgtgagg agaaggagaa gatcaagtac acgtgcaaat     1140

tcatcgaagt gcacaaatcc ggagctgtgt gtgcatatgt gtgtgcgctc agagtggaga     1200

gattctgctg tgcagtattc gctgcagagc ccgagtcctg gcatgtggaa ggcggctgtg     1260

tgaagaggtt taccacagag gaatgggtga aactccagat gaatgcccca tcaggttgaa     1320

gggggattaa taatctgtat gagggcggca gagatggctc agtggctaag agcactgact     1380

gctcttccag agatctgagc tgtaaccccc cccccccagc ctgaaacctg gttgctcagg     1440

tttcactgtt agcaagaaga gagcatggga gaggggggag gagcctgccg ccctatcgtt     1500

catcctaccc tttgtccacc cgagactaga ggggtgtgtc cgttccacgc agacaaaggg     1560

gcccagaggg tctgtggcag tggtcacctg aaactggact ccaggatgat ttggcgggaa     1620

tgggcccctt ccccctcctt cataaaattg agctttgctc agaaaaaaaa aaaaaaaaaa     1680

aaaa                                                                  1684


<210>  2
<211>  378
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gly Thr Arg Leu Glu Ala Thr Glu Gln Ser Asn His Arg Thr Gln 
1               5                   10                  15      


Arg Asn Asp Ile Gln Leu Glu Asn Ala Lys Ala Ala Gly Lys Met Gly 
            20                  25                  30          


Ile Ser Val Asp Leu Glu Ala Lys Tyr Ala Lys Leu Gly Leu Asn Leu 
        35                  40                  45              


Gly Ala Ile Thr Phe Gly Glu Lys Asp Arg Lys Lys Met Lys Asn Ser 
    50                  55                  60                  


His Leu Arg Lys Gln Glu Asn Ala Asn Ile Ser Leu Ala Val Cys Ala 
65                  70                  75                  80  


Leu Leu Asn Ser Gly Gly Gly Ala Ile Lys Val Lys Ile Glu Asn Glu 
                85                  90                  95      


Asn Tyr Ser Leu Thr Arg Asp Gly Leu Gly Leu Asp Leu Glu Ala Ser 
            100                 105                 110         


Leu Cys Lys Cys Leu Pro Phe Val Gln Trp His Leu Asp Phe Thr Glu 
        115                 120                 125             


Ser Glu Gly Tyr Ile Tyr Ile Tyr Val Lys Ser Trp Ser Gln Glu Ile 
    130                 135                 140                 


Phe Gly Leu Pro Ile Gly Thr Leu Arg Thr Asn Leu Tyr Val Arg Ser 
145                 150                 155                 160 


Met Ser Ser Ser Val Gln Val Ser Ala Ala Ala Ala Leu Glu Phe Leu 
                165                 170                 175     


Gln Asp Leu Glu Glu Thr Gly Gly Arg Pro Cys Val Arg Pro Glu Leu 
            180                 185                 190         


Pro Ala Ser Ile Ala Phe Pro Glu Val Glu Gly Glu Trp His Leu Glu 
        195                 200                 205             


Asp Leu Ala Ala Ala Leu Phe Asn Arg Thr Glu Phe Gln Tyr Glu Glu 
    210                 215                 220                 


Thr Phe Pro Phe Thr Arg Ser Arg Tyr Val Glu Val Thr Leu Leu Ser 
225                 230                 235                 240 


Ala Lys Arg Leu Arg Lys Arg Ile Lys Glu Leu Leu Pro Gln Thr Val 
                245                 250                 255     


Ser Ala Phe Ala Asn Thr Asp Gly Gly Phe Leu Phe Ile Gly Leu Asp 
            260                 265                 270         


Gly Lys Thr Gln Gln Ile Ile Gly Phe Glu Ala Glu Lys Ser Asp Leu 
        275                 280                 285             


Val Leu Leu Glu Ser Glu Ile Glu Lys His Ile Arg Gln Leu Pro Val 
    290                 295                 300                 


Thr His Phe Cys Glu Glu Lys Glu Lys Ile Lys Tyr Thr Cys Lys Phe 
305                 310                 315                 320 


Ile Glu Val His Lys Ser Gly Ala Val Cys Ala Tyr Val Cys Ala Leu 
                325                 330                 335     


Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Ala Glu Pro Glu Ser 
            340                 345                 350         


Trp His Val Glu Gly Gly Cys Val Lys Arg Phe Thr Thr Glu Glu Trp 
        355                 360                 365             


Val Lys Leu Gln Met Asn Ala Pro Ser Gly 
    370                 375             


<210>  3
<211>  1696
<212>  DNA
<213>  Mus musculus

<400>  3
agtctgtgca atgctttaat gcagcaagga acaaagaact cacatgggct tagaggtgaa       60

cacacaacca gggctgcagt tagaactctt ccaagtgcca aagcccaccg gcgaagacat      120

ctgctggcca ggacttgttg cagacagagg gtctttctca ggtgacacta gcctgcttta      180

ccaagactgc tgacatgggt actagacttg aggcaactga gcaaagcaac cacagaactc      240

agaggaatga cattcagctg gaaaatgcaa aggctgctgg gaaaatgggc atcagtgttg      300

atctggaagc caaatatgct aagctgggtc taaatctcgg agcaatcact tttggagaga      360

aggataggaa gaaaatgaag aattctcacc tcagaaaaca ggagaatgca aacatctctc      420

tagctgtatg tgctctcctg aattcgggag gtggagcaat caaggttaaa attgaaaatg      480

aaaattatag tctcactagg gatggcctgg gactagattt ggaagcctct ctttgtaaat      540

gtctgccctt tgtccagtgg cacctggact tcacggagag cgaaggctac atttatatct      600

acgtgaaatc gtggagccaa gaaatctttg ggctgcctat tggcacccta agaaccaatt      660

tgtatgtaag gagcatgtca tcttctgtac aagtgagcgc cgctgctgcc ctggaatttc      720

tccaggacct ggaggaaact ggagggagac cctgtgtcag accagagttg cctgcaagca      780

tagccttccc tgaagtggaa ggagaatggc acctggagga tttggctgct gcattgttta      840

acaggacaga atttcagtac gaggaaactt tcccctttac cagatccaga tatgttgaag      900

ttacattgct ttcagcgaaa cgcctgcgaa aacgcatcaa agagctcctc cctcaaactg      960

tttctgcttt tgcaaacacg gatgggggat ttttgttcat tggtttggat ggcaaaaccc     1020

agcaaattat tggttttgaa gcagagaaga gcgatctcgt gcttctagag agtgaaatag     1080

aaaagcacat ccggcagctg cctgtcactc acttctgtga ggagaaggag aagatcaagt     1140

acacgtgcaa attcatcgaa gtgcacaaat ccggagctgt gtgtgcatat gtgtgtgcgc     1200

tcagagtgga gagattctgc tgtgcagtat tcgctgcaga gcccgagtcc tggcatgtgg     1260

aaggcggctg tgtgaagagg tttaccacag aggaatgggt gaaactccag atgaatgccc     1320

catcaggttg aagggggatt aataatctgt atgagggcgg cagagatggc tcagtggcta     1380

agagcactga ctgctcttcc agagatctga gctgtaaccc ccccccccca gcctgaaacc     1440

tggttgctca ggtttcactg ttagcaagaa gagagcatgg gagagggggg aggagcctgc     1500

cgccctatcg ttcatcctac cctttgtcca cccgagacta gaggggtgtg tccgttccac     1560

gcagacaaag gggcccagag ggtctgtggc agtggtcacc tgaaactgga ctccaggatg     1620

atttggcggg aatgggcccc ttccccctcc ttcataaaat tgagctttgc tcagaaaaaa     1680

aaaaaaaaaa aaaaaa                                                     1696


<210>  4
<211>  1767
<212>  DNA
<213>  Mus musculus

<400>  4
ttggtggctc ctagcgttgt acaatcacat tttgacacaa ggggttgggc aatggtgtct       60

ccattgctct tttgctctga cttaggcagg gcggggtggg ggtgggggtt ggtaggtggg      120

gcagttgtca gtcataggac aggagaaagt attggtgata aattggtgat taggccttat      180

ctgggccacc tggcttgaag gtctttgact ccaagccctg gtggtcaggc cttaccctgg      240

atatttgacc tgtaactcaa gatgagaagg caacaaagga gctagttcct gggaacatag      300

actcagctgg accctgccag ccgatggaga acttgtcccc gaggtggctg gactcggaga      360

gctgtctcct tataaatgct ctcctggctg cctccttcct taagcctggg cactgcactt      420

tgtccttgat ggagaagtcc ccagagtttg ctgcagttct aatcccagac ctttggagtt      480

gaattccttc tcactgactt tggaactgaa ctggagctcg gaggaggagc tcggaggagg      540

agctcggagg aggaggagga ggaggaggag gagggaggag ggaggagagt gaagagggga      600

gagaaagaag agaagacttc aggcacacag agcatgggca ctggactttc tccacccagc      660

agctgcctct gtccagatgc tgctcctccc tggctccccc actttcccta cccctgttct      720

tttcttcctc atgtccctca aagccctggt tgttggcttg ccctggtctc tggctagtct      780

tgtgacattc cttaggaacg ggagggtaca gttctgagca agaggttgtg cttgggatac      840

tggaggaggg tgactcattg gactccccct agcaacttct tctttcacct cctgacaagt      900

acagaaggaa aattttgtct ttcttcattt ttggtcttct tcattactga tgcaaatatt      960

ctcctttacg tttttgcatg tttccatcaa cccacgagaa ctccagaaac ctcctgtact     1020

ttatttctta aattagagat taagaaagag attctaaagg tctctgagtc agtttcctca     1080

gagctggtct ggtggtgaca ggcaatgaaa cagcccacag ggaagaaaga gccctgttct     1140

ggacccttag gctggaggga cagtggagtt ctggacctct ggaagggcag tcagtgctct     1200

tatccactga accatctctc cagccctatt tcttttcttt tcttatcttt tcttttttaa     1260

tatttatttt attggatatt ttctttattt acatttcaaa tgttatcccc tttcctggtc     1320

ctggccccgg tccttccttc ctcccccaac tccctctccc atccaccccc aactcccttt     1380

cccttccctc aagccccctc tcccacccca ccccccctcc ccaatcagtt tcttaaggct     1440

ggttagggag gtgttactgt aacaaagtag caaaagaggt gtactgcttt agggtagccc     1500

tgggaatccc atagagagaa ggaatctgct ggcagagagg atcctgctgt gcccatctta     1560

aacccgggac tggagggact ctaaaggcgt taacaagggc acctgctctt ttgagcaaat     1620

ggactttgct gcttgggaat gcctgaggca gatagaaatc tgactagtca actgtgagct     1680

tgtgttacag tctgcccaat agaaaagtgg aggcagggct ttcacttcct ggagggtgac     1740

agttctggga tttccagtct tccacca                                         1767


<210>  5
<211>  3461
<212>  DNA
<213>  Mus musculus

<400>  5
ttggtggctc ctagcgttgt acaatcacat tttgacacaa ggggttgggc aatggtgtct       60

ccattgctct tttgctctga cttaggcagg gcggggtggg ggtgggggtt ggtaggtggg      120

gcagttgtca gtcataggac aggagaaagt attggtgata aattggtgat taggccttat      180

ctgggccacc tggcttgaag gtctttgact ccaagccctg gtggtcaggc cttaccctgg      240

atatttgacc tgtaactcaa gatgagaagg caacaaagga gctagttcct gggaacatag      300

actcagctgg accctgccag ccgatggaga acttgtcccc gaggtggctg gactcggaga      360

gctgtctcct tataaatgct ctcctggctg cctccttcct taagcctggg cactgcactt      420

tgtccttgat ggagaagtcc ccagagtttg ctgcagttct aatcccagac ctttggagtt      480

gaattccttc tcactgactt tggaactgaa ctggagctcg gaggaggagc tcggaggagg      540

agctcggagg aggaggagga ggaggaggag gagggaggag ggaggagagt gaagagggga      600

gagaaagaag agaagacttc aggcacacag agcatgggca ctggactttc tccacccagc      660

agctgcctct gtccagatgc tgctcctccc tggctccccc actttcccta cccctgttct      720

tttcttcctc atgtccctca aagccctggt tgttggcttg ccctggtctc tggctagtct      780

tgtgacattc cttaggaacg ggagggtaca gttctgagca agaggttgtg cttgggatac      840

tggaggaggg tgactcattg gactccccct agcaacttct tctttcacct cctgacaagt      900

acagaaggaa aattttgtct ttcttcattt ttggtcttct tcattactga tgcaaatatt      960

ctcctttacg tttttgcatg tttccatcaa cccacgagaa ctccagaaac ctcctgtact     1020

ttatttctta aattagagat taagaaagag attctaaagg tctctgagtc agtttcctca     1080

gagctggtct ggtggtgaca ggcaatgaaa cagcccacag ggaagaaaga gccctgttct     1140

ggacccttag gctggaggga cagtggagtt ctggacctct ggaagggcag tcagtgctct     1200

tatccactga accatctctc cagccctatt tcttttcttt tcttatcttt tcttttttaa     1260

tatttatttt attggatatt ttctttattt acatttcaaa tgttatcccc tttcctggtc     1320

ctggccccgg tccttccttc ctcccccaac tccctctccc atccaccccc aactcccttt     1380

cccttccctc aagccccctc tcccacccca ccccccctcc ccaatcagtt tcttaaggct     1440

ggttagggag gtgttactgt aacaaagtag caaaagaggt gtactgcttt agggtagccc     1500

tgggaatccc atagagagaa ggaatctgct ggcagagagg atcctgctgt gcccatctta     1560

aacccgggac tggagggact ctaaaggcgt taacaagggc acctgctctt ttgagcaaat     1620

ggactttgct gcttgggaat gcctgaggca gatagaaatc tgactagtca actgtgagct     1680

tgtgttacag tctgcccaat agaaaagtgg aggcagggct ttcacttcct ggagggtgac     1740

agttctggga tttccagtct tccaccagtc tgtgcaatgc tttaatgcag caaggaacaa     1800

agaactcaca tgggcttaga ggtgaacaca caaccagggc tgcagttaga actcttccaa     1860

gtgccaaagc ccaccggcga agacatctgc tggccaggac ttgttgcaga cagagggtct     1920

ttctcagtga cactagcctg ctttaccaag actgctgaca tgggtactag acttgaggca     1980

actgagcaaa gcaaccacag aactcagagg aatgacattc agctggaaaa tgcaaaggct     2040

gctgggaaaa tgggcatcag tgttgatctg gaagccaaat atgctaagct gggtctaaat     2100

ctcggagcaa tcacttttgg agagaaggat aggaagaaaa tgaagaattc tcacctcaga     2160

aaacaggaga atgcaaacat ctctctagct gtatgtgctc tcctgaattc gggaggtgga     2220

gcaatcaagg ttaaaattga aaatgaaaat tatagtctca ctagggatgg cctgggacta     2280

gatttggaag cctctctttg taaatgtctg ccctttgtcc agtggcacct ggacttcacg     2340

gagagcgaag gctacattta tatctacgtg aaatcgtgga gccaagaaat ctttgggctg     2400

cctattggca ccctaagaac caatttgtat gtaaggagca tgtcatcttc tgtacaagtg     2460

agcgccgctg ctgccctgga atttctccag gacctggagg aaactggagg gagaccctgt     2520

gtcagaccag agttgcctgc aagcatagcc ttccctgaag tggaaggaga atggcacctg     2580

gaggatttgg ctgctgcatt gtttaacagg acagaatttc agtacgagga aactttcccc     2640

tttaccagat ccagatatgt tgaagttaca ttgctttcag cgaaacgcct gcgaaaacgc     2700

atcaaagagc tcctccctca aactgtttct gcttttgcaa acacggatgg gggatttttg     2760

ttcattggtt tggatggcaa aacccagcaa attattggtt ttgaagcaga gaagagcgat     2820

ctcgtgcttc tagagagtga aatagaaaag cacatccggc agctgcctgt cactcacttc     2880

tgtgaggaga aggagaagat caagtacacg tgcaaattca tcgaagtgca caaatccgga     2940

gctgtgtgtg catatgtgtg tgcgctcaga gtggagagat tctgctgtgc agtattcgct     3000

gcagagcccg agtcctggca tgtggaaggc ggctgtgtga agaggtttac cacagaggaa     3060

tgggtgaaac tccagatgaa tgccccatca ggttgaaggg ggattaataa tctgtatgag     3120

ggcggcagag atggctcagt ggctaagagc actgactgct cttccagaga tctgagctgt     3180

aacccccccc ccccagcctg aaacctggtt gctcaggttt cactgttagc aagaagagag     3240

catgggagag gggggaggag cctgccgccc tatcgttcat cctacccttt gtccacccga     3300

gactagaggg gtgtgtccgt tccacgcaga caaaggggcc cagagggtct gtggcagtgg     3360

tcacctgaaa ctggactcca ggatgatttg gcgggaatgg gccccttccc cctccttcat     3420

aaaattgagc tttgctcaga aaaaaaaaaa aaaaaaaaaa a                         3461


<210>  6
<211>  2078
<212>  DNA
<213>  Rattus norvegicus

<400>  6
cttcaatgca gcaaagaaca gagaactcaa gtgagcttag aggtgagctc acagccaggg       60

ctgcagatag aactctccca agtgccaaca accagcctcg aagacgtccc cggccaggac      120

ttgttgcaga caacactagt tgtctttctc aagtgacact agcctgcctc accaaaggag      180

ctgactgctg gcatgggcgc tggacttcat gcagctgagc aagacaacca cagagctcac      240

aggaagggca ctgggcagca aaatgcaaaa gctgctggga aaatgggcat cagcgttgac      300

ctggaagctg agtatgctaa gctgggtcta aatctaggag caatcactct tggagagaag      360

gataggagga aaatgaagaa ctctcacctc aggaaaaagg agaatgagaa catctctctg      420

gctgtgtgtg ctctcctgaa ttcaggaggt ggagcaatca aggttaaaat tgaaaatgaa      480

aattatagtc tcactaggga tggcctggga ctagatttgg aaacctctct ttgtaaatgt      540

ctcccgtttg tccagtggta cctggacttc actgagagca aaggctacat ttatatctac      600

gtgagagcat ggagtcagga aatctttggg ctgccgattg gcaccctgag caccaatttg      660

tacgtaaggg tcgtttcatc ctccgtacaa gtgagcgctg atgctgcgct acaatttctc      720

caggacctgg aggaagctgg agggagaccc cgtgtcagac cagagttgcc tgcaaggaaa      780

gcctgccctg gagtggaagg agaatgtcac caggaggatt tggctgctgc attttttaac      840

aagaccgaat ttcagtatga ggaaactttc ttctttacca ggtccaggta tgttgaagtt      900

acatcacttt cagtgaaacg cctgcgaaaa cgcatcagag agatcctccc tcgaactgtt      960

tctgcattcg caaacacgga tgggggatat ttgttcattg gcttggatgg gaaaaaacag     1020

caaataattg gctttgaagc agagaagagc gaccttgtgc atctagagag tgaaatagaa     1080

aagtgcatcc gacagctgcc tgtcactcac ttctgtgagg agagggagaa gatcaagtac     1140

acgtgcaaat tcatggaagt gcacaaaccc ggagccgcgt gttcatacgt gtgtgcgctc     1200

cgagtggaga gattctgctg tgcagtgttc gctgcagagc ccgaatcctg gcacgtggaa     1260

gacagctgtg tgaagaggtt tgccgcagag gactgggtta ggctccagat gggttccagg     1320

gaagcttgga aaaggtgact aataatcagt tagtgaaaaa taaagatttt taagttcccc     1380

acttgaccct gctgtgagga caagtgcacc tcccaaaaga atagcatcac atgttttggt     1440

gaggtagcct ggctatagcc accacaaacc atctggcctc gataaggcct gacacaacag     1500

ttctgaggaa aacaagaact agggtcagct tgccccagaa gcagggtggc ctagagttga     1560

actgaggcca tgtagttttc cctataaatc ccttccccta attgggctcg gggttgactc     1620

ctctgtctcc tgtgtgagat acgtgtcatc cccagagctc tggcttctca aatatactta     1680

ttatatcaag accggtttct cgtgagttct tgggggttgc gtcatcttga gatttgagtg     1740

ggggtcttcc ccaccttggt ggtctttcat tacaaccatc tgtaatgata tctgatgccc     1800

tcttctaact attttccagc atccacatgg tgattcacaa ccacctagaa ccccagttta     1860

tttatttttt ttggctgttt tttttttttt tttggtttta catggagtgg tttaatgaga     1920

gaagaagggt agaagaggag aggaacaaag gaggctggcc atgggcacgt ggggggaagg     1980

ggggatgggg agagaaggga cagggacaaa gaggacacca gaagaggaga gcaagagaga     2040

ggagtaagag caaactgatg agcttccagg gactaagc                             2078


<210>  7
<211>  381
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Gly Ala Gly Leu His Ala Ala Glu Gln Asp Asn His Arg Ala His 
1               5                   10                  15      


Arg Lys Gly Thr Gly Gln Gln Asn Ala Lys Ala Ala Gly Lys Met Gly 
            20                  25                  30          


Ile Ser Val Asp Leu Glu Ala Glu Tyr Ala Lys Leu Gly Leu Asn Leu 
        35                  40                  45              


Gly Ala Ile Thr Leu Gly Glu Lys Asp Arg Arg Lys Met Lys Asn Ser 
    50                  55                  60                  


His Leu Arg Lys Lys Glu Asn Glu Asn Ile Ser Leu Ala Val Cys Ala 
65                  70                  75                  80  


Leu Leu Asn Ser Gly Gly Gly Ala Ile Lys Val Lys Ile Glu Asn Glu 
                85                  90                  95      


Asn Tyr Ser Leu Thr Arg Asp Gly Leu Gly Leu Asp Leu Glu Thr Ser 
            100                 105                 110         


Leu Cys Lys Cys Leu Pro Phe Val Gln Trp Tyr Leu Asp Phe Thr Glu 
        115                 120                 125             


Ser Lys Gly Tyr Ile Tyr Ile Tyr Val Arg Ala Trp Ser Gln Glu Ile 
    130                 135                 140                 


Phe Gly Leu Pro Ile Gly Thr Leu Ser Thr Asn Leu Tyr Val Arg Val 
145                 150                 155                 160 


Val Ser Ser Ser Val Gln Val Ser Ala Asp Ala Ala Leu Gln Phe Leu 
                165                 170                 175     


Gln Asp Leu Glu Glu Ala Gly Gly Arg Pro Arg Val Arg Pro Glu Leu 
            180                 185                 190         


Pro Ala Arg Lys Ala Cys Pro Gly Val Glu Gly Glu Cys His Gln Glu 
        195                 200                 205             


Asp Leu Ala Ala Ala Phe Phe Asn Lys Thr Glu Phe Gln Tyr Glu Glu 
    210                 215                 220                 


Thr Phe Phe Phe Thr Arg Ser Arg Tyr Val Glu Val Thr Ser Leu Ser 
225                 230                 235                 240 


Val Lys Arg Leu Arg Lys Arg Ile Arg Glu Ile Leu Pro Arg Thr Val 
                245                 250                 255     


Ser Ala Phe Ala Asn Thr Asp Gly Gly Tyr Leu Phe Ile Gly Leu Asp 
            260                 265                 270         


Gly Lys Lys Gln Gln Ile Ile Gly Phe Glu Ala Glu Lys Ser Asp Leu 
        275                 280                 285             


Val His Leu Glu Ser Glu Ile Glu Lys Cys Ile Arg Gln Leu Pro Val 
    290                 295                 300                 


Thr His Phe Cys Glu Glu Arg Glu Lys Ile Lys Tyr Thr Cys Lys Phe 
305                 310                 315                 320 


Met Glu Val His Lys Pro Gly Ala Ala Cys Ser Tyr Val Cys Ala Leu 
                325                 330                 335     


Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Ala Glu Pro Glu Ser 
            340                 345                 350         


Trp His Val Glu Asp Ser Cys Val Lys Arg Phe Ala Ala Glu Asp Trp 
        355                 360                 365             


Val Arg Leu Gln Met Gly Ser Arg Glu Ala Trp Lys Arg 
    370                 375                 380     


<210>  8
<211>  1767
<212>  DNA
<213>  Homo sapiens

<400>  8
atggacctcg ccagaaaaga atttctgcgt ggaaatggct tagctgctgg gaaaatgaac       60

atcagtattg atttagacac aaactatgct gagctggttc taaatgtggg aagagtcact      120

cttggagaga acaatagaaa aaaaatgaag gattgtcaac tgagaaaaca gcagaatgaa      180

aatgtctcac gagctgtgtg tgctctgctg aattctggag ggggagtgat caaggctgaa      240

gttgagaata aaggctatag ttataaaaaa gatggaatag ggctagattt ggaaaattct      300

tttagtaaca tgctgccatt tgttcctaat ttcctggact tcatgcagaa tggtaactac      360

tttcacattt ttgtgaaatc atggagcttg gaaacctctg gtccgcagat tgccacgttg      420

agctccagtt tgtacaagag agatgtaacg tctgcaaaag tcatgaatgc ttctgctgca      480

ctggagttcc tcaaagacat ggaaaaaact ggagggagag catatttaag accagaattc      540

cctgcaaaaa gggcctgtgt tgatgtacaa gaagaaagta acatggaagc cttggctgct      600

gattttttta acagaacaga acttggttat aaagaaaaat tgacctttac tgaatccaca      660

cacgttgaaa taaaaaactt ctcgactgaa aagttgttac aacgaattac agagattctc      720

cctcaatatg tttctgcatt tgcaaatact gatggaggat atttattcgt tggtctaaat      780

gaagataaag aagtaattgg ctttaaagca gagaagagtt atcttactaa gttagaagaa      840

gtaacaaaaa attccattgg gaaactgcct gtgcatcact tctgtgtgga gaaggggacg      900

ataaattact tatgcaaatt ccttggagta tatgataaag gaaggctttg tggatatgtg      960

tatgcactca gagtggaacg cttctgctgt gcagtgtttg ctaaaaagcc tgattcctgg     1020

cacgtgaaag ataacagagt taagcagttg accgagaagg aatggatcca gttcatggtg     1080

gattcagaac cagtatgtga ggaactgccc tctccagcaa gtacatcatc acctgtctcc     1140

cagagttatc ctcttcgtga atatattaac ttcaaaattc agccactgag atatcacctt     1200

ccagggctat cagaaaagat aacttgtgct ccaaaaacct tctgcagaaa tctgttctca     1260

caacatgaag gacttaagca attaatatgt gaagaaatgg gctctgtcaa taagggctca     1320

ctgatcttct ctaggagctg gtctttggat ctgggcttgc aagagaacca caaagtcctc     1380

tgtgatgctc ttctgatttc ccaggacaag cctccagtcc tatacacctt ccacatggta     1440

caggatgagg agtttaaaga ctattctaca caaactgccc aaactttaaa acagaagctg     1500

gcaaaaattg gtggttacac taaaaaagtg tgtgtcatga caaagatctt ctacttgagc     1560

cctgaaggca agacaagctg ccagtatgat ttaaactcgc aagtaattta ccctgaatcc     1620

tactattgga caacagctca aacaatgaaa gacttggaaa aggccctttc aaatatctta     1680

cctaaggaga atcaaatctt tttgtttgtt tgtttgtttc gtttttgttt gtttgtttgt     1740

tggtttgttt gttttttctt gagatga                                         1767


<210>  9
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Leu Ala Arg Lys Glu Phe Leu Arg Gly Asn Gly Leu Ala Ala 
1               5                   10                  15      


Gly Lys Met Asn Ile Ser Ile Asp Leu Asp Thr Asn Tyr Ala Glu Leu 
            20                  25                  30          


Val Leu Asn Val Gly Arg Val Thr Leu Gly Glu Asn Asn Arg Lys Lys 
        35                  40                  45              


Met Lys Asp Cys Gln Leu Arg Lys Gln Gln Asn Glu Asn Val Ser Arg 
    50                  55                  60                  


Ala Val Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Lys Ala Glu 
65                  70                  75                  80  


Val Glu Asn Lys Gly Tyr Ser Tyr Lys Lys Asp Gly Ile Gly Leu Asp 
                85                  90                  95      


Leu Glu Asn Ser Phe Ser Asn Met Leu Pro Phe Val Pro Asn Phe Leu 
            100                 105                 110         


Asp Phe Met Gln Asn Gly Asn Tyr Phe His Ile Phe Val Lys Ser Trp 
        115                 120                 125             


Ser Leu Glu Thr Ser Gly Pro Gln Ile Ala Thr Leu Ser Ser Ser Leu 
    130                 135                 140                 


Tyr Lys Arg Asp Val Thr Ser Ala Lys Val Met Asn Ala Ser Ala Ala 
145                 150                 155                 160 


Leu Glu Phe Leu Lys Asp Met Glu Lys Thr Gly Gly Arg Ala Tyr Leu 
                165                 170                 175     


Arg Pro Glu Phe Pro Ala Lys Arg Ala Cys Val Asp Val Gln Glu Glu 
            180                 185                 190         


Ser Asn Met Glu Ala Leu Ala Ala Asp Phe Phe Asn Arg Thr Glu Leu 
        195                 200                 205             


Gly Tyr Lys Glu Lys Leu Thr Phe Thr Glu Ser Thr His Val Glu Ile 
    210                 215                 220                 


Lys Asn Phe Ser Thr Glu Lys Leu Leu Gln Arg Ile Thr Glu Ile Leu 
225                 230                 235                 240 


Pro Gln Tyr Val Ser Ala Phe Ala Asn Thr Asp Gly Gly Tyr Leu Phe 
                245                 250                 255     


Val Gly Leu Asn Glu Asp Lys Glu Val Ile Gly Phe Lys Ala Glu Lys 
            260                 265                 270         


Ser Tyr Leu Thr Lys Leu Glu Glu Val Thr Lys Asn Ser Ile Gly Lys 
        275                 280                 285             


Leu Pro Val His His Phe Cys Val Glu Lys Gly Thr Ile Asn Tyr Leu 
    290                 295                 300                 


Cys Lys Phe Leu Gly Val Tyr Asp Lys Gly Arg Leu Cys Gly Tyr Val 
305                 310                 315                 320 


Tyr Ala Leu Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Lys Lys 
                325                 330                 335     


Pro Asp Ser Trp His Val Lys Asp Asn Arg Val Lys Gln Leu Thr Glu 
            340                 345                 350         


Lys Glu Trp Ile Gln Phe Met Val Asp Ser Glu Pro Val Cys Glu Glu 
        355                 360                 365             


Leu Pro Ser Pro Ala Ser Thr Ser Ser Pro Val Ser Gln Ser Tyr Pro 
    370                 375                 380                 


Leu Arg Glu Tyr Ile Asn Phe Lys Ile Gln Pro Leu Arg Tyr His Leu 
385                 390                 395                 400 


Pro Gly Leu Ser Glu Lys Ile Thr Cys Ala Pro Lys Thr Phe Cys Arg 
                405                 410                 415     


Asn Leu Phe Ser Gln His Glu Gly Leu Lys Gln Leu Ile Cys Glu Glu 
            420                 425                 430         


Met Gly Ser Val Asn Lys Gly Ser Leu Ile Phe Ser Arg Ser Trp Ser 
        435                 440                 445             


Leu Asp Leu Gly Leu Gln Glu Asn His Lys Val Leu Cys Asp Ala Leu 
    450                 455                 460                 


Leu Ile Ser Gln Asp Lys Pro Pro Val Leu Tyr Thr Phe His Met Val 
465                 470                 475                 480 


Gln Asp Glu Glu Phe Lys Asp Tyr Ser Thr Gln Thr Ala Gln Thr Leu 
                485                 490                 495     


Lys Gln Lys Leu Ala Lys Ile Gly Gly Tyr Thr Lys Lys Val Cys Val 
            500                 505                 510         


Met Thr Lys Ile Phe Tyr Leu Ser Pro Glu Gly Lys Thr Ser Cys Gln 
        515                 520                 525             


Tyr Asp Leu Asn Ser Gln Val Ile Tyr Pro Glu Ser Tyr Tyr Trp Thr 
    530                 535                 540                 


Thr Ala Gln Thr Met Lys Asp Leu Glu Lys Ala Leu Ser Asn Ile Leu 
545                 550                 555                 560 


Pro Lys Glu Asn Gln Ile Phe Leu Phe Val Cys Leu Phe Arg Phe Cys 
                565                 570                 575     


Leu Phe Val Cys Trp Phe Val Cys Phe Phe Leu Arg 
            580                 585             


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense murine Slfn2

<400>  10
ctcacctcag aaaacaggag aatgc                                             25


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-sense, murine Slfn2

<400>  11
cagaagtgag tgacaggcag ctg                                               23


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense Slfn2 -1766

<400>  12
cggctagctt ggtggctcct agcgrr                                            26


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense Slfn2 -1265

<400>  13
cggctagcgg aactgaactg gagct                                             25


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-sense Slfn 2 +198

<400>  14
ccctcgagcc atgtcagcag ttggtaaagc                                        30


