                         SEQUENCE LISTING

<110>  Corimmun GmbH
 
<120>  Binding compounds to human beta1-adrenoreceptor (beta1-AR) and their 
       use in the measurement of auto-anti-beta1-AR antibodies 

<130>  T1607 PCT S3

<150>  EP 11 16 9621.7
<151>  2011-06-10

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggcgcgg gggtgctcgt cctgggcgcc tccgagcccg gtaacctgtc gtcggccgca       60

ccgctccccg acggcgcggc caccgcggcg cggctgctgg tgcccgcgtc gccgcccgcc      120

tcgttgctgc ctcccgccag cgaaagcccc gagccgctgt ctcagcagtg gacagcgggc      180

atgggtctgc tgatggcgct catcgtgctg ctcatcgtgg cgggcaatgt gctggtgatc      240

gtggccatcg ccaagacgcc gcggctgcag acgctcacca acctcttcat catgtccctg      300

gccagcgccg acctggtcat ggggctgctg gtggtgccgt tcggggccac catcgtggtg      360

tggggccgct gggagtacgg ctccttcttc tgcgagctgt ggacctcagt ggacgtgctg      420

tgcgtgacgg ccagcatcga gaccctgtgt gtcattgccc tggaccgcta cctcgccatc      480

acctcgccct tccgctacca gagcctgctg acgcgcgcgc gggcgcgggg cctcgtgtgc      540

accgtgtggg ccatctcggc cctggtgtcc ttcctgccca tcctcatgca ctggtggcgg      600

gcggagagcg acgaggcgcg ccgctgctac aacgacccca agtgctgcga cttcgtcacc      660

aaccgggcct acgccatcgc ctcgtccgta gtctccttct acgtgcccct gtgcatcatg      720

gccttcgtgt acctgcgggt gttccgcgag gcccagaagc aggtgaagaa gatcgacagc      780

tgcgagcgcc gtttcctcgg cggcccagcg cggccgccct cgccctcgcc ctcgcccgtc      840

cccgcgcccg cgccgccgcc cggacccccg cgccccgccg ccgccgccgc caccgccccg      900

ctggccaacg ggcgtgcggg taagcggcgg ccctcgcgcc tcgtggccct gcgcgagcag      960

aaggcgctca agacgctggg catcatcatg ggcgtcttca cgctctgctg gctgcccttc     1020

ttcctggcca acgtggtgaa ggccttccac cgcgagctgg tgcccgaccg cctcttcgtc     1080

ttcttcaact ggctgggcta cgccaactcg gccttcaacc ccatcatcta ctgccgcagc     1140

cccgacttcc gcaaggcctt ccagggactg ctctgctgcg cgcgcagggc tgcccgccgg     1200

cgccacgcga cccacggaga ccggccgcgc gcctcgggct gtctggcccg gcccggaccc     1260

ccgccatcgc ccggggccgc ctcggacgac gacgacgacg atgtcgtcgg ggccacgccg     1320

cccgcgcgcc tgctggagcc ctgggccggc tgcaacggcg gggcggcggc ggacagcgac     1380

tcgagcctgg acgagccgtg ccgccccggc ttcgcctcgg aatccaaggt gtag           1434


<210>  2
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 


Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 


Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     


Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         


Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             


Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 


Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 


Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         


Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             


Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 


Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val 
465                 470                 475         


<210>  3
<211>  315
<212>  DNA
<213>  Mus musculus

<400>  3
ctggtgaagc ctggggcttc agtgaagata tcctgcaagg cttctggtta ctcattcact       60

gactactaca tgcactgggt gaagcaaagc catgtaaaga gccttgagtg gattggacgt      120

attaatcctt acagtggtgc tcctagctac acccagaatt tcaaggccaa ggccagcttg      180

actgtagata agtcctccag cacagcctac atggagctcc acagcctgac atctgaggac      240

tctgcagtct attactgcgc aagagctaac tgggacgggt actttgacta ctggggccaa      300

ggcaccactc tcaca                                                       315


<210>  4
<211>  104
<212>  PRT
<213>  Mus musculus

<400>  4

Leu Val Lys Pro Gly Ala Ser Val Lys Ile Cys Lys Ala Ser Gly Tyr 
1               5                   10                  15      


Ser Phe Thr Asp Tyr Tyr Met His Trp Val Lys Gln Ser His Val Lys 
            20                  25                  30          


Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Tyr Ser Gly Ala Pro Ser 
        35                  40                  45              


Tyr Thr Gln Asn Phe Lys Ala Lys Ala Ser Leu Thr Val Asp Lys Ser 
    50                  55                  60                  


Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Ala Arg Ala Asn Trp Asp Gly Tyr Phe Asp Tyr 
                85                  90                  95      


Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 


<210>  5
<211>  291
<212>  DNA
<213>  Mus musculus

<400>  5
atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc aagtgtaagt       60

tacatgtact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca      120

tccaaattgg cttctggagt ccctgttcgc ttcagtggca gtgggtctgg gacctcttac      180

tctctcacaa tcagcagcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg      240

agtagtaacc catggacgtt cggtggaggc accaaattgg aaatcaaacg g               291


<210>  6
<211>  97
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
1               5                   10                  15      


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            20                  25                  30          


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        35                  40                  45              


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    50                  55                  60                  


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
65                  70                  75                  80  


Ser Ser Asn Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95      


Arg 
    


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Tyr Tyr Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ile Asn Pro Tyr Ser Gly Ala Pro Ser Tyr Thr Gln Asn Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  9

Ala Asn Trp Asp Gly Tyr Phe Asp Tyr 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Gln Trp Ser Ser Asn Pro Trp Thr 
1               5                   


<210>  13
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"


<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  /note="Abu"

<400>  13

Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys Cys 
1               5                   10                  15      


Xaa Asp Phe Val Thr Gly 
            20          


<210>  14
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"


<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  /note="Abu"

<400>  14

Ala Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys Cys Xaa Asp Phe 
1               5                   10                  15      


Val Gln 
        


<210>  15
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"


<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  /note="Abu"

<400>  15

Ala Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys 
1               5                   10                  15      


Cys Xaa Asp Phe Val Thr Asn Arg Gln 
            20                  25  


<210>  16
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"

<400>  16

Ala Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys Cys Ser Asp Phe 
1               5                   10                  15      


Val Gln 
        


<210>  17
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"

<400>  17

His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp 
1               5                   10                  15      


Pro Lys Cys Cys Asp Phe Val Thr Asn Arg 
            20                  25      


<210>  18
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"

<400>  18

Ala Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys 
1               5                   10                  15      


Cys Cys Asp Phe Val Thr Asn Arg Gln 
            20                  25  


<210>  19
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence 
       homologous to an ECII epitope of human BETA1-AR"

<400>  19

Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp Pro Lys Cys 
1               5                   10                  15      


Cys Asp Phe Val Thr Asn Arg 
            20              


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  20
ggcatcctca ccctgaagta                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  21
gtcaggcagc tcgtagctct                                                   20


<210>  22
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"


<220>
<221>  variation
<222>  (12)..(12)
<223>  /note= g=t

<220>
<221>  variation
<222>  (18)..(18)
<223>  /note= c=t

<220>
<221>  variation
<222>  (21)..(21)
<223>  /note= a=g

<400>  22
ggtgatatcg tgctcaccca atctccagca at                                     32


<210>  23
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  23
gggaagatgg atccagttgg tgcagcatca gc                                     32


<210>  24
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  24
gaggtgaagc tgcaggagtc aggacctagc ctggtg                                 36


<210>  25
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"


<220>
<221>  variation
<222>  (5)..(5)
<223>  /note="c=g"

<220>
<221>  variation
<222>  (15)..(15)
<223>  /note="c=g"

<220>
<221>  variation
<222>  (20)..(20)
<223>  /note="a=t"

<400>  25
aggtccagct gcagcagtga gg                                                22


<210>  26
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  26
ccaggggcca gtggatagac aagcttgggt gtcgtttt                               38


<210>  27
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  27
gggaagatgg atccagttg                                                    19


<210>  28
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligonuclotide primer"

<400>  28
caggggccag tggataga                                                     18


<210>  29
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer


<220>
<221>  variation
<222>  (10)..(10)
<223>  /note="a=t"

<220>
<221>  variation
<222>  (13)..(13)
<223>  /note="a=c"

<220>
<221>  variation
<222>  (22)..(22)
<223>  /note="a=t"

<400>  29
ggtgatatca tgatgaccca aactccactc tc                                     32


<210>  30
<211>  309
<212>  DNA
<213>  Rattus norvegicus

<400>  30
ctgcttatca gccttggagg tcaagcctcc atctcttgcc ggtctagtca gagcctgata       60

cacagtaatg gaaacaccta ctttgattgg ttcctgcaga agccaggcca gtctccacag      120

ctcctcatct atcaggtttc caacagattt tctggggtcc cagacaggtt cagtggtagt      180

gggtcaggga cggatttcac cctcaagatc agcagattag agcctgagga cttgggagtt      240

tattactgct tacaacgtac acatgatccg tacacgtttg gagctgggac caagctggaa      300

ctgaaacgg                                                              309


<210>  31
<211>  103
<212>  PRT
<213>  Rattus norvegicus

<400>  31

Leu Leu Ile Ser Leu Gly Gly Gln Ala Ser Ile Ser Cys Arg Ser Ser 
1               5                   10                  15      


Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr Phe Asp Trp Phe Leu 
            20                  25                  30          


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Val Ser Asn 
        35                  40                  45              


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Lys Ile Ser Arg Leu Glu Pro Glu Asp Leu Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Leu Gln Arg Thr His Asp Pro Tyr Thr Phe Gly Ala Gly 
                85                  90                  95      


Thr Lys Leu Glu Leu Lys Arg 
            100             


<210>  32
<211>  315
<212>  DNA
<213>  Rattus norvegicus

<400>  32
ttactgcagc ctggaaggtc catgaaactc tcctgtgcag cctcaggatt cactttcagt       60

aactatggca tggcctgggt ccgccaggct ccaaagaagg gtctggactg ggtcgcatat      120

attagttatg atggtggtgg cacttactat cgcgactccg tgaagggccg attcactgtc      180

tccagagata atgcaaaaag caccctatac ctgctaatgg acagtctgag gtctgaggac      240

acggccactt attactgtac aaccgggaac tttgattact ggggccaagg agtcatggtc      300

acggtctcct cagct                                                       315


<210>  33
<211>  105
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Leu Leu Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Lys 
            20                  25                  30          


Lys Gly Leu Asp Trp Val Ala Tyr Ile Ser Tyr Asp Gly Gly Gly Thr 
        35                  40                  45              


Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    50                  55                  60                  


Ala Lys Ser Thr Leu Tyr Leu Leu Met Asp Ser Leu Arg Ser Glu Asp 
65                  70                  75                  80  


Thr Ala Thr Tyr Tyr Cys Thr Thr Gly Asn Phe Asp Tyr Trp Gly Gln 
                85                  90                  95      


Gly Val Met Val Thr Val Ser Ser Ala 
            100                 105 


<210>  34
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Arg Ser Ser Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr Phe Asp 
1               5                   10                  15      


<210>  35
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Gln Val Ser Asn Arg Phe Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Leu Gln Arg Thr His Asp Pro Tyr Thr 
1               5                   


<210>  37
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Asn Tyr Gly Met Ala 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  38

Tyr Ile Ser Tyr Asp Gly Gly Gly Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Gly Asn Phe Asp Tyr 
1               5   


<210>  40
<211>  279
<212>  DNA
<213>  Mus musculus

<400>  40
atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc aagtgtaagt       60

tacatgtatt ggtatcagca gaagtcaggc acctccccca gaagatggat ttatgacaca      120

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gacctcttac      180

tctctcacaa tcagcagcat ggaggctgaa gatgttgcca cttattactg ccagcagtgg      240

agtactaacc catggacgtt cggtggaggc accaagctg                             279


<210>  41
<211>  93
<212>  PRT
<213>  Mus musculus

<400>  41

Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
1               5                   10                  15      


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            20                  25                  30          


Pro Arg Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        35                  40                  45              


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    50                  55                  60                  


Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp 
65                  70                  75                  80  


Ser Thr Asn Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
                85                  90              


<210>  42
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  42
ctggtgaagc ctggggcttc agtgaggata tcctgcaagg cttctggtta ctcattcact       60

gactactaca tacactgggt gaaacaaagc catgtaaaga gccttgagtg gattggacgt      120

attaatcctt acaatggtgc tactaactac aaccagaatt tcaaggacaa ggccaacttg      180

actgtagata agtcctccag cacagcctac atggagctcc acagcctgac atctgaggac      240

tctgcagtct atttctgtgc aagagctaac tgggacggtt actttgacga ctggggtcaa      300

ggcaccactc tcacagtctc ctca                                             324


<210>  43
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  43

Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly 
1               5                   10                  15      


Tyr Ser Phe Thr Asp Tyr Tyr Ile His Trp Val Lys Gln Ser His Val 
            20                  25                  30          


Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr 
        35                  40                  45              


Asn Tyr Asn Gln Asn Phe Lys Asp Lys Ala Asn Leu Thr Val Asp Lys 
    50                  55                  60                  


Ser Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp 
65                  70                  75                  80  


Ser Ala Val Tyr Phe Cys Ala Arg Ala Asn Trp Asp Gly Tyr Phe Asp 
                85                  90                  95      


Asp Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105             


<210>  44
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  44

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  45
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  45

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  46

Gln Gln Trp Ser Thr Asn Pro Trp Thr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  47

Asp Tyr Tyr Ile His 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  48

Arg Ile Asn Pro Tyr Asn Gly Ala Thr Asn Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  49

Ala Asn Trp Asp Gly Tyr Phe Asp Asp 
1               5                   


<210>  50
<211>  279
<212>  DNA
<213>  Mus musculus

<400>  50
atgtctgcat ctccagggga gaaggtcacc atgacctgca gagccagctc aagtgtaagt       60

tacatgtact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca      120

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gacctcttac      180

tctctcacaa tcagcagcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg      240

agtagtaacc catggacgtt cggtggaggc accaagctg                             279


<210>  51
<211>  93
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
1               5                   10                  15      


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            20                  25                  30          


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        35                  40                  45              


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    50                  55                  60                  


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
65                  70                  75                  80  


Ser Ser Asn Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
                85                  90              


<210>  52
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  52
ctggtgaagc ctggggcttc agtgaagata tcctgcaagg cttctggtta ctcattcact       60

gactactaca tgcactgggt gaagcaaagc catgtaaaga gccttgaatg gattggacgt      120

attaatcctt acaatggtgc tactaacttc aaccagaatt tcatggacaa ggccagcttg      180

cctgtagtta agtcctccag cacagcctac ctggacctcc acagcctgac atctgaggac      240

tctgcagtct attactgtgc aagagctaac tgggacgggt tctttgacta ctggggccaa      300

ggcaccactc tcaccgtctc ctca                                             324


<210>  53
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  53

Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
1               5                   10                  15      


Tyr Ser Phe Thr Asp Tyr Tyr Met His Trp Val Lys Gln Ser His Val 
            20                  25                  30          


Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr 
        35                  40                  45              


Asn Phe Asn Gln Asn Phe Met Asp Lys Ala Ser Leu Pro Val Val Lys 
    50                  55                  60                  


Ser Ser Ser Thr Ala Tyr Leu Asp Leu His Ser Leu Thr Ser Glu Asp 
65                  70                  75                  80  


Ser Ala Val Tyr Tyr Cys Ala Arg Ala Asn Trp Asp Gly Phe Phe Asp 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105             


<210>  54
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  54

Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  55
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  55

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Gln Trp Ser Ser Asn Pro Trp Thr 
1               5                   


<210>  57
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  57

Asp Tyr Tyr Met His 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  58

Arg Ile Asn Pro Tyr Asn Gly Ala Thr Asn Phe Asn Gln Asn Phe Met 
1               5                   10                  15      


Asp 
    


<210>  59
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  59

Ala Asn Trp Asp Gly Phe Phe Asp Tyr 
1               5                   


<210>  60
<211>  279
<212>  DNA
<213>  Mus musculus

<400>  60
atgtctgcat ctccagggga gaaggtcacc atgacctgca gagccagctc aagtgtaagt       60

tacatgtact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca      120

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gacctcttac      180

tctctcacaa tcagcagcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg      240

agtagtaacc catggacgtt cggtggaggc accaagctg                             279


<210>  61
<211>  93
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
1               5                   10                  15      


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            20                  25                  30          


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        35                  40                  45              


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    50                  55                  60                  


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
65                  70                  75                  80  


Ser Ser Asn Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                85                  90              


<210>  62
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  62
ctggtgaagc ctggggcttc agtgaagata tcctgcaagg cttctggtta ctcattcact       60

gactactaca tgcactgggt gaaacaaagc catgttaaga gccttgagtg gattggacgt      120

gttaatcctt tcaatggtgc tactaactac gaccagaatt tcaaggccaa ggccagcttg      180

actgtagata agtcctccag cacagcccac atggagctcc acagcctgac atctgaggac      240

tctgctgtct attactgtgc aagaggagat tacgacgggg tctttactta ctggggccaa      300

gggactctgg tcactgtctc t                                                321


<210>  63
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  63

Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
1               5                   10                  15      


Tyr Ser Phe Thr Asp Tyr Tyr Met His Trp Val Lys Gln Ser His Val 
            20                  25                  30          


Lys Ser Leu Glu Trp Ile Gly Arg Val Asn Pro Phe Asn Gly Ala Thr 
        35                  40                  45              


Asn Tyr Asp Gln Asn Phe Lys Ala Lys Ala Ser Leu Thr Val Asp Lys 
    50                  55                  60                  


Ser Ser Ser Thr Ala His Met Glu Leu His Ser Leu Thr Ser Glu Asp 
65                  70                  75                  80  


Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asp Tyr Asp Gly Val Phe Thr 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105         


<210>  64
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  64

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  65
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  65

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  66

Gln Gln Trp Ser Ser Asn Pro Tyr Thr 
1               5                   


<210>  67
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  67

Asp Tyr Tyr Met His 
1               5   


<210>  68
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  68

Arg Val Asn Pro Phe Asn Gly Ala Thr Asn Tyr Asp Gln Asn Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  69
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  69

Gly Asp Tyr Asp Gly Val Phe Thr Tyr 
1               5                   


