                         SEQUENCE LISTING

<110>  Tao, Ma
       Shusen, Xu
       Zhijun, Liu
       Bo, Zhang
       Ning, Shen
       Hai, Yang
       Wei, Zhang
       Yuhua, Li
       Sunghwan, Moon
       Maengsup, Kim
   
 
<120>  GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, 
       PHARMACEUTICAL COMPOSITIONS AND USE THEREOF

<130>  121911CN07

<150>  201110156296.2
<151>  2011-06-10

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  2

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Ala Met Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  3

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 4-fluoro-Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Met oxide

<400>  4

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 4-nitro-Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Met oxide

<400>  5

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Met oxide

<400>  6

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Met oxide

<400>  7

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Phe Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 4-nitro-Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  8

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analogy


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = phenyl glycine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  9

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  10

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  11

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Phe Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  12

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Tyr Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-methyl-Tyr

<400>  13

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-fluoro-Phe

<400>  14

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 4-nitro-Phe

<400>  15

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Met Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analogg


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  16

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Glu Ala Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<400>  17

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Val Arg Gln 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  18

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  19

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  20

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  21

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25                  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  22

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Cys 
            20                  25                  30  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  23

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  24

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Ala Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  25

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Ile Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  26

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Leu Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-chloro-Phe

<400>  27

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Gln Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa =  4-chloro-Phe

<400>  28

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Lys Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Pal

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-chloro-Phe

<400>  29

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Met Glu Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-chloro-Phe

<400>  30

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Ile His Gln Lys Asp Xaa Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys(palmitoyl)

<400>  31

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Xaa Gly 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys(palmitoyl)

<400>  32

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly 
            20                  25                  


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Lys(palmitoyl)

<400>  33

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Xaa Asn Gly 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Lys(palmitoyl)

<400>  34

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Leu Phe Ile Glu Trp Leu Xaa Asn Gly 
            20                  25                  


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  35

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  36

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Glu Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring formed between side chains at positions 12 and 16

<400>  37

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Glu Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  38

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Glu Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  39
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chains at positions 16 and 20

<400>  39

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Glu Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  40

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Val Lys Gly 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  41

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  42

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  43
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  43

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 
            20                  25                  30      


<210>  44
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  44

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  45
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  45

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Lys Lys 
            20                  25                  30          


Lys Lys 
        


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = 4-chloro-Phe

<400>  46

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Xaa Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = Nal

<400>  47

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Xaa Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Pal

<400>  48

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys-maleimidopropionate

<400>  49

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Xaa Gly 
            20                  25                  


<210>  50
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  50

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys(palmitoyl)

<400>  51

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Xaa Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  52
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  52

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  53
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys-maleimidopropionate

<400>  53

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  54
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  54

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  45  


<210>  55
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(biotin)

<400>  55

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  56
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  56

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg 
        35  


<210>  57
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = Lys(palmitoyl)

<400>  57

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Lys Lys Lys Lys Xaa 
        35                  40                  45  


<210>  58
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = Lus-maleimidopropionate

<400>  58

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  45  


<210>  59
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = Lys(biotin)

<400>  59

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Lys Lys Lys Lys Xaa 
        35                  40                  45  


<210>  60
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring formed between side chains at positions 12 and 16

<400>  60

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Glu Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  61
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring formed between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = Lys(palmitoyl)

<400>  61

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Glu Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Xaa 
            20                  25                  30  


<210>  62
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring formed between side chains at positions  20 and 24

<400>  62

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  63
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  63

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  64
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(20kDa PEG)

<400>  64

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  65
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(40kDa PEG)

<400>  65

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  66
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys-(gamma-Glu-palmitoyl)

<400>  66

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  67
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys-(gamma-Glu-gamma-Glu-palmitoyl)

<400>  67

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  68
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys-(gamma-Glu-palmitoyl)

<400>  68

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Xaa Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  69
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys-(gamma-Glu-gamma-Glu-palmitoyl)

<400>  69

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Xaa Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  70
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys-(gamma-Glu-palmitoyl)

<400>  70

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  71
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys-(gamma-Glu-gamma-Glu-palmitoyl)

<400>  71

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  72
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa =  Lys(palmitoyl)

<400>  72

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  73
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Cys(20kDa PEG)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  73

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Xaa Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  74
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Cys(40kDa PEG)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  74

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Xaa Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  75
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring formed between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  75

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Glu Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  76
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring formed between side chains at positions 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  76

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Glu Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  77
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring formed between side chains at positions 20 and 24

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  77

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  78
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring formed between side chains at positions 24 and 28

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  78

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  79
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Nle

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  79

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Xaa Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  80
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  80

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  81
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(hexadecanedioic acyl)

<400>  81

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  82
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  82

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  83
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa = Ser (cholic acyl)

<400>  83

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  84
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa = Lys(palmitoyl)

<400>  84

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  85
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa = Lys(palmitoyl)

<400>  85

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  86
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Cys(40kDa PEG)

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa = Lys(palmitoyl)

<400>  86

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Xaa Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  87
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Cys(40kDa PEG)

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa = Lys(palmitoyl)

<400>  87

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Xaa Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  88
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(palmitoyl)

<400>  88

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  89
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  89

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  90
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  90

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  91
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(40kDa PEG)

<400>  91

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  92
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(40k PEG)

<400>  92

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  93
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<400>  93

Tyr Xaa Gln Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  94
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(40kDa PEG)

<400>  94

Tyr Xaa Gln Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  95
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Lys(40kDa PEG)

<400>  95

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  96
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = Cys(palmitoyl)

<400>  96

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  97
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = Lys(Biontin)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Lys(Biontin)

<400>  97

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Xaa 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Ala Trp Leu Val Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  98
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Cys(40kDa PEG)

<400>  98

Tyr Xaa Glu Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Met Glu Lys 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Xaa Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  99
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  99

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  100
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  100

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


