                         SEQUENCE LISTING

<110>  Board of Regents of Oklahoma State University
 
<120>  ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES WITH CONTROL OF 
       CELL-TO-CELL VIRUS TRANSMISSION FOR ENHANCED SAFETY OF LIVE VIRUS
        VACCINES

<130>  50894/12-163 WO

<150>  US 61/492261
<151>  2011-06-01

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  771
<212>  DNA
<213>  respiratory syncytial virus

<400>  1
atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc tgttcaatac       60

aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc catgttccaa      120

tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat actagtgaaa      180

caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag aagtgcagtg      240

ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga tgaaagaagc      300

aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct aacatgccta      360

aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact caaccctaca      420

catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa agtcataata      480

ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact tgaaaatata      540

acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta ctcaggatta      600

ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa gccacaaagt      660

caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta tgttaccaca      720

aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta a               771


<210>  2
<211>  771
<212>  DNA
<213>  respiratory syncytial virus

<400>  2
atggagacct acgtgaacaa gctgcacgag ggcagcacct acaccgccgc cgtgcagtac       60

aacgtgctgg agaaggacga cgaccccgcc agcctgacca tctgggtgcc catgttccag      120

agcagcatgc ccgccgacct gctgatcaag gagctggcca acgtgaacat cctggtgaag      180

cagatcagca cccccaaggg gcctagcctg cgcgtgatga tcaacagccg cagcgccgtg      240

ctggcccaga tgcccagcaa gttcaccatc tgcgccaacg tgagcctgga cgagcgcagc      300

aagctggcct acgacgtgac caccccctgc gagatcaagg cctgcagcct gacctgcctg      360

aagagcaaga acatgctgac caccgtgaag gacctgacca tgaagaccct gaaccccacc      420

cacgacatca tcgccctgtg cgagttcgag aacatcgtga ccagcaagaa agtgatcatc      480

cccacctacc tgcgcagcat cagcgtgcgc aacaaggacc tgaacaccct ggagaacatc      540

accaccaccg agttcaagaa cgccatcacc aacgccaaga tcatccccta cagcggcctg      600

ctgctggtga tcaccgtgac cgacaacaag ggcgccttca agtacatcaa gccccagagc      660

cagttcatcg tggacctggg cgcctacctg gagaaggaga gcatctacta cgtgaccacc      720

aactggaagc acaccgccac ccgcttcgcc atcaagccta tggaggacta a               771


<210>  3
<211>  256
<212>  PRT
<213>  respiratory syncytial virus

<400>  3

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  4
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  4

Met Ser Trp Lys Asp Ala Ser Gly Trp Ser Glu Thr Tyr Val Asn Lys 
1               5                   10                  15      


Leu His Glu Gly Ser Thr Tyr Thr Ala Ala Val Gln Tyr Asn Val Leu 
            20                  25                  30          


Glu Lys Asp Asp Asp Pro Ala Ser Leu Thr Ile Trp Val Pro Met Phe 
        35                  40                  45              


Gln Ser Ser Met Pro Ala Asp Leu Leu Ile Lys Glu Leu Ala Asn Val 
    50                  55                  60                  


Asn Ile Leu Val Lys Gln Ile Ser Thr Pro Lys Gly Pro Ser Leu Arg 
65                  70                  75                  80  


Val Met Ile Asn Ser Arg Ser Ala Val Leu Ala Gln Met Pro Ser Lys 
                85                  90                  95      


Phe Thr Ile Cys Ala Asn Val Ser Leu Asp Glu Arg Ser Lys Leu Ala 
            100                 105                 110         


Tyr Asp Val Thr Thr Pro Cys Glu Ile Lys Ala Cys Ser Leu Thr Cys 
        115                 120                 125             


Leu Lys Ser Lys Asn Met Leu Thr Thr Val Lys Asp Leu Thr Met Lys 
    130                 135                 140                 


Thr Leu Asn Pro Thr His Asp Ile Ile Ala Leu Cys Glu Phe Glu Asn 
145                 150                 155                 160 


Ile Val Thr Ser Lys Lys Val Ile Ile Pro Thr Tyr Leu Arg Ser Ile 
                165                 170                 175     


Ser Val Arg Asn Lys Asp Leu Asn Thr Leu Glu Asn Ile Thr Thr Thr 
            180                 185                 190         


Glu Phe Lys Asn Ala Ile Thr Asn Ala Lys Ile Ile Pro Tyr Ser Gly 
        195                 200                 205             


Leu Leu Leu Val Ile Thr Val Thr Asp Asn Lys Gly Ala Phe Lys Tyr 
    210                 215                 220                 


Ile Lys Pro Gln Ser Gln Phe Ile Val Asp Leu Gly Ala Tyr Leu Glu 
225                 230                 235                 240 


Lys Glu Ser Ile Tyr Tyr Val Thr Thr Asn Trp Lys His Thr Ala Thr 
                245                 250                 255     


Arg Phe Ala Ile Lys Pro Met Glu Asp 
            260                 265 


<210>  5
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  5

Met Glu Thr Tyr Val Asn Lys Leu His Glu Ser Trp Lys Asp Ala Ser 
1               5                   10                  15      


Gly Trp Ser Gly Ser Thr Tyr Thr Ala Ala Val Gln Tyr Asn Val Leu 
            20                  25                  30          


Glu Lys Asp Asp Asp Pro Ala Ser Leu Thr Ile Trp Val Pro Met Phe 
        35                  40                  45              


Gln Ser Ser Met Pro Ala Asp Leu Leu Ile Lys Glu Leu Ala Asn Val 
    50                  55                  60                  


Asn Ile Leu Val Lys Gln Ile Ser Thr Pro Lys Gly Pro Ser Leu Arg 
65                  70                  75                  80  


Val Met Ile Asn Ser Arg Ser Ala Val Leu Ala Gln Met Pro Ser Lys 
                85                  90                  95      


Phe Thr Ile Cys Ala Asn Val Ser Leu Asp Glu Arg Ser Lys Leu Ala 
            100                 105                 110         


Tyr Asp Val Thr Thr Pro Cys Glu Ile Lys Ala Cys Ser Leu Thr Cys 
        115                 120                 125             


Leu Lys Ser Lys Asn Met Leu Thr Thr Val Lys Asp Leu Thr Met Lys 
    130                 135                 140                 


Thr Leu Asn Pro Thr His Asp Ile Ile Ala Leu Cys Glu Phe Glu Asn 
145                 150                 155                 160 


Ile Val Thr Ser Lys Lys Val Ile Ile Pro Thr Tyr Leu Arg Ser Ile 
                165                 170                 175     


Ser Val Arg Asn Lys Asp Leu Asn Thr Leu Glu Asn Ile Thr Thr Thr 
            180                 185                 190         


Glu Phe Lys Asn Ala Ile Thr Asn Ala Lys Ile Ile Pro Tyr Ser Gly 
        195                 200                 205             


Leu Leu Leu Val Ile Thr Val Thr Asp Asn Lys Gly Ala Phe Lys Tyr 
    210                 215                 220                 


Ile Lys Pro Gln Ser Gln Phe Ile Val Asp Leu Gly Ala Tyr Leu Glu 
225                 230                 235                 240 


Lys Glu Ser Ile Tyr Tyr Val Thr Thr Asn Trp Lys His Thr Ala Thr 
                245                 250                 255     


Arg Phe Ala Ile Lys Pro Met Glu Asp 
            260                 265 


<210>  6
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  6

Met Ala Ala Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  7
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  7

Met Glu Thr Ala Ala Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  8
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  8

Met Glu Thr Tyr Val Ala Ala Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  9
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  9

Met Glu Thr Tyr Val Asn Lys Ala Ala Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  10
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  10

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ala Ala Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  11
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  11

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Ala Ala Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  12
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  12

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Ala Ala Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  13
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  13

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ala Ala Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  14
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  14

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Ala Ala Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  15
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  15

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Ala Ala Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  16
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  16

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Ala 
        115                 120                 125             


Ala Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  17
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  17

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Ala Ala Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  18
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  18

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Ala Ala Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  19
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  19

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Ala Ala Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  20
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  20

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Ala Ala Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  21
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  21

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Ala Ala Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  22
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  22

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Ala Ala Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  23
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  23

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Ala Ala Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  24
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  24

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ala 
    130                 135                 140                 


Gly Leu Cys Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  25
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  25

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Ala Ala Glu Phe Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  26
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  26

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Ala Ala Glu Asn Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  27
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  27

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Ala Ala Ile Val Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  28
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  28

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ala Ala Thr Ser Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


<210>  29
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of M protein

<400>  29

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Met Pro Ala Asp Leu Leu 
        35                  40                  45              


Ile Lys Glu Leu Ala Asn Val Asn Ile Leu Val Lys Gln Ile Ser Thr 
    50                  55                  60                  


Pro Lys Gly Pro Ser Leu Arg Val Met Ile Asn Ser Arg Ser Ala Val 
65                  70                  75                  80  


Leu Ala Gln Met Pro Ser Lys Phe Thr Ile Cys Ala Asn Val Ser Leu 
                85                  90                  95      


Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu Ile 
            100                 105                 110         


Lys Ala Cys Ser Leu Thr Cys Leu Lys Ser Lys Asn Met Leu Thr Thr 
        115                 120                 125             


Val Lys Asp Leu Thr Met Lys Thr Leu Asn Pro Thr His Asp Ile Ile 
    130                 135                 140                 


Ala Leu Cys Glu Phe Glu Asn Ile Val Ala Ala Lys Lys Val Ile Ile 
145                 150                 155                 160 


Pro Thr Tyr Leu Arg Ser Ile Ser Val Arg Asn Lys Asp Leu Asn Thr 
                165                 170                 175     


Leu Glu Asn Ile Thr Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn Ala 
            180                 185                 190         


Lys Ile Ile Pro Tyr Ser Gly Leu Leu Leu Val Ile Thr Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile Val 
    210                 215                 220                 


Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr Thr 
225                 230                 235                 240 


Asn Trp Lys His Thr Ala Thr Arg Phe Ala Ile Lys Pro Met Glu Asp 
                245                 250                 255     


