                         SEQUENCE LISTING

<110>  Dyax Corp.
       Sexton, Daniel J.
       TenHoor, Christopher
 
<120>  Fc RECEPTOR BINDING PROTEINS

<130>  D0617.70028WO00

<140>  N/A
<141>  2012-06-01

<150>  61/492,617
<151>  2011-06-02

<150>  61/498,266
<151>  2011-06-17

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  365
<212>  PRT
<213>  H. sapiens

<400>  1

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  2
<211>  366
<212>  PRT
<213>  R. Rattus

<400>  2

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
            20                  25                  30          


Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
        35                  40                  45              


Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
    50                  55                  60                  


Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
65                  70                  75                  80  


Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                85                  90                  95      


Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
            100                 105                 110         


Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
        115                 120                 125             


Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
    130                 135                 140                 


Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
145                 150                 155                 160 


Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                165                 170                 175     


Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
            180                 185                 190         


Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
        195                 200                 205             


Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
    210                 215                 220                 


Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
225                 230                 235                 240 


Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                245                 250                 255     


Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
            260                 265                 270         


His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
        275                 280                 285             


Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
    290                 295                 300                 


Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
305                 310                 315                 320 


Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                325                 330                 335     


Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
            340                 345                 350         


Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
        355                 360                 365     


<210>  3
<211>  119
<212>  PRT
<213>  H. sapiens

<400>  3

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  4
<211>  119
<212>  PRT
<213>  R. Rattus

<400>  4

Met Ala Arg Ser Val Thr Val Ile Phe Leu Val Leu Val Ser Leu Ala 
1               5                   10                  15      


Val Val Leu Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gln Phe His Pro Pro Gln Ile Glu Ile Glu Leu Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Asn Ile Glu Met Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Val Tyr Ala Cys Arg Val Lys His Val Thr Leu Lys Glu Pro Lys Thr 
            100                 105                 110         


Val Thr Trp Asp Arg Asp Met 
        115                 


<210>  5
<211>  1510
<212>  DNA
<213>  H. sapiens

<400>  5
gttcttcagg tacgaggagg gcattgttgt cagtctggac cgagcccgca gagcccctcc       60

tcggcgtcct ggtcccggcc gtgcccgcgg tgtcccggga ggaaggggcg ggccgggggt      120

cgggaggagt cacgtgcccc ctcccgcccc aggtcgtcct ctcagcatgg gggtcccgcg      180

gcctcagccc tgggcgctgg ggctcctgct ctttctcctt cctgggagcc tgggcgcaga      240

aagccacctc tccctcctgt accaccttac cgcggtgtcc tcgcctgccc cggggactcc      300

tgccttctgg gtgtccggct ggctgggccc gcagcagtac ctgagctaca atagcctgcg      360

gggcgaggcg gagccctgtg gagcttgggt ctgggaaaac caggtgtcct ggtattggga      420

gaaagagacc acagatctga ggatcaagga gaagctcttt ctggaagctt tcaaagcttt      480

ggggggaaaa ggtccctaca ctctgcaggg cctgctgggc tgtgaactgg gccctgacaa      540

cacctcggtg cccaccgcca agttcgccct gaacggcgag gagttcatga atttcgacct      600

caagcagggc acctggggtg gggactggcc cgaggccctg gctatcagtc agcggtggca      660

gcagcaggac aaggcggcca acaaggagct caccttcctg ctattctcct gcccgcaccg      720

cctgcgggag cacctggaga ggggccgcgg aaacctggag tggaaggagc ccccctccat      780

gcgcctgaag gcccgaccca gcagccctgg cttttccgtg cttacctgca gcgccttctc      840

cttctaccct ccggagctgc aacttcggtt cctgcggaat gggctggccg ctggcaccgg      900

ccagggtgac ttcggcccca acagtgacgg atccttccac gcctcgtcgt cactaacagt      960

caaaagtggc gatgagcacc actactgctg cattgtgcag cacgcggggc tggcgcagcc     1020

cctcagggtg gagctggaat ctccagccaa gtcctccgtg ctcgtggtgg gaatcgtcat     1080

cggtgtcttg ctactcacgg cagcggctgt aggaggagct ctgttgtgga gaaggatgag     1140

gagtgggctg ccagcccctt ggatctccct tcgtggagac gacaccgggg tcctcctgcc     1200

caccccaggg gaggcccagg atgctgattt gaaggatgta aatgtgattc cagccaccgc     1260

ctgaccatcc gccattccga ctgctaaaag cgaatgtagt caggcccctt tcatgctgtg     1320

agacctcctg gaacactggc atctctgagc ctccagaagg ggttctgggc ctagttgtcc     1380

tccctctgga gccccgtcct gtggtctgcc tcagtttccc ctcctaatac atatggctgt     1440

tttccacctc gataatataa cacgagtttg ggcccgaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa                                                            1510


<210>  6
<211>  984
<212>  DNA
<213>  H. sapiens

<400>  6
atgggggtcc cgcggcctca gccctgggcg ctggggctcc tgctctttct ccttcctggg       60

agcctgggcg cagaaagcca cctctccctc ctgtaccacc ttaccgcggt gtcctcgcct      120

gccccgggga ctcctgcctt ctgggtgtcc ggctggctgg gcccgcagca gtacctgagc      180

tacaatagcc tgcggggcga ggcggagccc tgtggagctt gggtctggga aaaccaggtg      240

tcctggtatt gggagaaaga gaccacagat ctgaggatca aggagaagct ctttctggaa      300

gctttcaaag ctttgggggg aaaaggtccc tacactctgc agggcctgct gggctgtgaa      360

ctgggccctg acaacacctc ggtgcccacc gccaagttcg ccctgaacgg cgaggagttc      420

atgaatttcg acctcaagca gggcacctgg ggtggggact ggcccgaggc cctggctatc      480

agtcagcggt ggcagcagca ggacaaggcg gccaacaagg agctcacctt cctgctattc      540

tcctgcccgc accgcctgcg ggagcacctg gagaggggcc gcggaaacct ggagtggaag      600

gagcccccct ccatgcgcct gaaggcccga cccagcagcc ctggcttttc cgtgcttacc      660

tgcagcgcct tctccttcta ccctccggag ctgcaacttc ggttcctgcg gaatgggctg      720

gccgctggca ccggccaggg tgacttcggc cccaacagtg acggatcctt ccacgcctcg      780

tcgtcactaa cagtcaaaag tggcgatgag caccactact gctgcattgt gcagcacgcg      840

gggctggcgc agcccctcag ggtggagctg gaatctccag ccaagtcctc ccggccgctc      900

gacgggctac gagcatcagt aacactacta ggcgcaggcc tactactatc actactacca      960

gcactactac gatttgggcc ataa                                             984


<210>  7
<211>  987
<212>  DNA
<213>  H. sapiens

<400>  7
aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag       60

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct      120

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      180

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      240

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      300

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      360

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa      420

gcagcatcat ggaggtttga agatgccgca tttggattgg atgaattcca aattctgctt      480

gcttgctttt taatattgat atgcttatac acttacactt tatgcacaaa atgtagggtt      540

ataataatgt taacatggac atgatcttct ttataattct actttgagtg ctgtctccat      600

gtttgatgta tctgagcagg ttgctccaca ggtagctcta ggagggctgg caacttagag      660

gtggggagca gagaattctc ttatccaaca tcaacatctt ggtcagattt gaactcttca      720

atctcttgca ctcaaagctt gttaagatag ttaagcgtgc ataagttaac ttccaattta      780

catactctgc ttagaatttg ggggaaaatt tagaaatata attgacagga ttattggaaa      840

tttgttataa tgaatgaaac attttgtcat ataagattca tatttacttc ttatacattt      900

gataaagtaa ggcatggttg tggttaatct ggtttatttt tgttccacaa gttaaataaa      960

tcataaaact tgatgtgtta tctctta                                          987


<210>  8
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region for DX-2504

<400>  8

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain variable region for DX-2504

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain Variable region for 532A-X53-C02

<400>  10

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  11
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain Variable region for 532A-X54-B03

<400>  11

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region CDR3 of 532A-X53-C02

<400>  12

Ser Ser Tyr Ala Gly Ser Gly Ile Tyr Val 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region CDR3 of 532A-X54-B03

<400>  13

Ala Ser Tyr Ala Gly Ser Gly Ile Tyr Val 
1               5                   10  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region CDR1

<400>  14

Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region CDR2

<400>  15

Gly Asp Ser Gln Arg Pro Ser 
1               5           


<210>  16
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length light chain for DX-2504

<400>  16

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  17
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length heavy chain for DX-2504

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  18
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length light chain for DX-2507

<400>  18

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  19
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length heavy chain for DX-2507

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  20
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fragment of DX-2504 heavy chain

<400>  20

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
1               5                   10                  15      


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            20                  25                  30          


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        35                  40                  45              


<210>  21
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  the C-terminal fragment of DX-2507 heavy chain

<400>  21

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
1               5                   10                  15      


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            20                  25                  30          


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        35                  40                  45          


<210>  22
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain variable region CDR1

<400>  22

Glu Tyr Ala Met Gly 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain variable region CDR2

<400>  23

Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain variable region CDR3

<400>  24

Leu Ala Ile Gly Asp Ser Tyr 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain variable region CDR3 of DX-2504

<400>  25

Cys Ser Tyr Ala Gly Ser Gly Ile Tyr Val 
1               5                   10  


<210>  26
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain constant region of DX-2507

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


