                         SEQUENCE LISTING

<110>  Idexx Laboratories, Inc.
       Murthy, Yerramilli
 
<120>  DETECTION OF DEGRADATION PRODUCTS OF FELINE NT-proBNP

<130>  10-999

<150>  US 61/491,580
<151>  2011-05-31

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  140
<212>  PRT
<213>  Canis familiaris


<220>
<221>  misc_feature
<223>  Canine preproBNP; SwissProt P16859

<400>  1

Met Glu Pro Cys Ala Ala Leu Pro Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ser Pro Leu Gly Gly Arg Pro His Pro Leu Gly Gly Arg 
            20                  25                  30          


Ser Pro Ala Ser Glu Ala Ser Glu Ala Ser Glu Ala Ser Gly Leu Trp 
        35                  40                  45              


Ala Val Gln Glu Leu Leu Gly Arg Leu Lys Asp Ala Val Ser Glu Leu 
    50                  55                  60                  


Gln Ala Glu Gln Leu Ala Leu Glu Pro Leu His Arg Ser His Ser Pro 
65                  70                  75                  80  


Ala Glu Ala Pro Glu Ala Gly Gly Thr Pro Arg Gly Val Leu Ala Pro 
                85                  90                  95      


His Asp Ser Val Leu Gln Ala Leu Arg Arg Leu Arg Ser Pro Lys Met 
            100                 105                 110         


Met His Lys Ser Gly Cys Phe Gly Arg Arg Leu Asp Arg Ile Gly Ser 
        115                 120                 125             


Leu Ser Gly Leu Gly Cys Asn Val Leu Arg Lys Tyr 
    130                 135                 140 


<210>  2
<211>  132
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<223>  Feline preproBNP; SwissProt Q9GLK4

<400>  2

Met Asp Pro Lys Thr Ala Leu Leu Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ser Pro Leu Gly Gly Arg Ser His Pro Leu Gly Gly Pro 
            20                  25                  30          


Gly Pro Ala Ser Glu Ala Ser Ala Ile Gln Glu Leu Leu Asp Gly Leu 
        35                  40                  45              


Arg Asp Thr Val Ser Glu Leu Gln Glu Ala Gln Met Ala Leu Gly Pro 
    50                  55                  60                  


Leu Gln Gln Gly His Ser Pro Ala Glu Ser Trp Glu Ala Gln Glu Glu 
65                  70                  75                  80  


Pro Pro Ala Arg Val Leu Ala Pro His Asp Asn Val Leu Arg Ala Leu 
                85                  90                  95      


Arg Arg Leu Gly Ser Ser Lys Met Met Arg Asp Ser Arg Cys Phe Gly 
            100                 105                 110         


Arg Arg Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys Asn Val 
        115                 120                 125             


Leu Arg Arg His 
    130         


<210>  3
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human preproBNP; SwissProt P16860

<400>  3

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210>  4
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Feline Synthetic NT-proBNP (fsNT-proBNP)

<400>  4

His Pro Leu Gly Gly Pro Gly Pro Ala Ser Glu Ala Ser Ala Ile Gln 
1               5                   10                  15      


Glu Leu Leu Asp Gly Leu Arg Asp Thr Val Ser Glu Leu Gln Glu Ala 
            20                  25                  30          


Gln Met Ala Leu Gly Pro Leu Gln Gln Gly His Ser Pro Ala Glu Ser 
        35                  40                  45              


Trp Glu Ala Gln Glu Glu Pro Pro Ala Arg Val Leu Ala Pro His Asp 
    50                  55                  60                  


Asn Val Leu Arg Ala Leu Arg Arg Leu Gly Ser Ser Lys Met 
65                  70                  75              


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP N-Terminal Peptide Plasma Degradent

<400>  5

Ala Ser Glu Ala Ser Ala Ile Gln Glu Leu Leu Asp Gly Leu Arg Asp 
1               5                   10                  15      


Thr Val Ser Glu Leu 
            20      


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP N-Terminal Peptide Plasma Degradent

<400>  6

Asp Gly Leu Arg Asp Thr Val Ser Glu Leu 
1               5                   10  


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP N-Terminal Peptide Plasma Degradent

<400>  7

Leu Asp Gly Leu Arg Asp Thr Val Ser Glu Leu Gln Glu Ala Gln Met 
1               5                   10                  15      


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP C-Terminal Peptide Plasma Degradent

<400>  8

Leu Gly Pro Leu Gln Gln Gly His Ser Pro Ala Glu Ser Trp Glu Ala 
1               5                   10                  15      


Gln Glu Glu Pro Pro Ala Arg 
            20              


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP C-Terminal Peptide Plasma Degradent

<400>  9

Leu Gly Pro Leu Gln Gln Gly His Ser Pro Ala Glu Ser Trp Glu Ala 
1               5                   10                  15      


Gln Glu Glu Pro Pro Ala Arg Val Leu Ala Pro His Asp Asn Val Leu 
            20                  25                  30          


Arg 
    


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP C-Terminal Peptide Plasma Degradent

<400>  10

Leu Gln Gln Gly His Ser Pro Ala Glu Ser Trp Glu Ala Gln Glu Glu 
1               5                   10                  15      


Pro Pro Ala Arg Val Leu Ala Pro His Asp Asn Val Leu Arg 
            20                  25                  30  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Feline NT-proBNP C-Terminal Peptide Plasma Degradent

<400>  11

Val Leu Ala Pro His Asp Asn Val Leu Arg 
1               5                   10  


