                         SEQUENCE LISTING

<110>  OREGON HEALTH AND SCIENCE UNIVERSITY
       THOMAS, George
 
<120>  METHODS AND KITS THAT IDENTIFY TUMORS RESPONSIVE TO SRC 
       INHIBITORS

<130>  1643-2

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccccgga gggcggagaa ctgggacgag gccgaggtag gcgcggagga ggcaggcgtc       60

gaagagtacg gccctgaaga agacggcggg gaggagtcgg gcgccgagga gtccggcccg      120

gaagagtccg gcccggagga actgggcgcc gaggaggaga tggaggccgg gcggccgcgg      180

cccgtgctgc gctcggtgaa ctcgcgcgag ccctcccagg tcatcttctg caatcgcagt      240

ccgcgcgtcg tgctgcccgt atggctcaac ttcgacggcg agccgcagcc ctacccaacg      300

ctgccgcctg gcacgggccg ccgcatccac agctaccgag gtcacctttg gctcttcaga      360

gatgcaggga cacacgatgg gcttctggtt aaccaaactg aattatttgt gccatctctc      420

aatgttgacg gacagcctat ttttgccaat atcacactgc cagtgtatac tctgaaagag      480

cgatgcctcc aggttgtccg gagcctagtc aagcctgaga attacaggag actggacatc      540

gtcaggtcgc tctacgaaga tctggaagac cacccaaatg tgcagaaaga cctggagcgg      600

ctgacacagg agcgcattgc acatcaacgg atgggagatt ga                         642


<210>  2
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  2
atggagatgg aaaaggagtt cgagcagatc gacaagtccg ggagctgggc ggccatttac       60

caggatatcc gacatgaagc cagtgacttc ccatgtagag tggccaagct tcctaagaac      120

aaaaaccgaa ataggtacag agacgtcagt ccctttgacc atagtcggat taaactacat      180

caagaagata atgactatat caacgctagt ttgataaaaa tggaagaagc ccaaaggagt      240

tacattctta cccagggccc tttgcctaac acatgcggtc acttttggga gatggtgtgg      300

gagcagaaaa gcaggggtgt cgtcatgctc aacagagtga tggagaaagg ttcgttaaaa      360

tgcgcacaat actggccaca aaaagaagaa aaagagatga tctttgaaga cacaaatttg      420

aaattaacat tgatctctga agatatcaag tcatattata cagtgcgaca gctagaattg      480

gaaaacctta caacccaaga aactcgagag atcttacatt tccactatac cacatggcct      540

gactttggag tccctgaatc accagcctca ttcttgaact ttcttttcaa agtccgagag      600

tcagggtcac tcagcccgga gcacgggccc gttgtggtgc actgcagtgc aggcatcggc      660

aggtctggaa ccttctgtct ggctgatacc tgcctcttgc tgatggacaa gaggaaagac      720

ccttcttccg ttgatatcaa gaaagtgctg ttagaaatga ggaagtttcg gatggggctg      780

atccagacag ccgaccagct gcgcttctcc tacctggctg tgatcgaagg tgccaaattc      840

atcatggggg actcttccgt gcaggatcag tggaaggagc tttcccacga ggacctggag      900

cccccacccg agcatatccc cccacctccc cggccaccca aacgaatcct ggagccacac      960

aatgggaaat gcagggagtt cttcccaaat caccagtggg tgaaggaaga gacccaggag     1020

gataaagact gccccatcaa ggaagaaaaa ggaagcccct taaatgccgc accctacggc     1080

atcgaaagca tgagtcaaga cactgaagtt agaagtcggg tcgtgggggg aagtcttcga     1140

ggtgcccagg ctgcctcccc agccaaaggg gagccgtcac tgcccgagaa ggacgaggac     1200

catgcactga gttactggaa gcccttcctg gtcaacatgt gcgtggctac ggtcctcacg     1260

gccggcgctt acctctgcta caggttcctg ttcaacagca acacatag                  1308


<210>  3
<211>  2481
<212>  DNA
<213>  Homo sapiens

<400>  3
atggagggcg ccggcggcgc gaacgacaag aaaaagataa gttctgaacg tcgaaaagaa       60

aagtctcgag atgcagccag atctcggcga agtaaagaat ctgaagtttt ttatgagctt      120

gctcatcagt tgccacttcc acataatgtg agttcgcatc ttgataaggc ctctgtgatg      180

aggcttacca tcagctattt gcgtgtgagg aaacttctgg atgctggtga tttggatatt      240

gaagatgaca tgaaagcaca gatgaattgc ttttatttga aagccttgga tggttttgtt      300

atggttctca cagatgatgg tgacatgatt tacatttctg ataatgtgaa caaatacatg      360

ggattaactc agtttgaact aactggacac agtgtgtttg attttactca tccatgtgac      420

catgaggaaa tgagagaaat gcttacacac agaaatggcc ttgtgaaaaa gggtaaagaa      480

caaaacacac agcgaagctt ttttctcaga atgaagtgta ccctaactag ccgaggaaga      540

actatgaaca taaagtctgc aacatggaag gtattgcact gcacaggcca cattcacgta      600

tatgatacca acagtaacca acctcagtgt gggtataaga aaccacctat gacctgcttg      660

gtgctgattt gtgaacccat tcctcaccca tcaaatattg aaattccttt agatagcaag      720

actttcctca gtcgacacag cctggatatg aaattttctt attgtgatga aagaattacc      780

gaattgatgg gatatgagcc agaagaactt ttaggccgct caatttatga atattatcat      840

gctttggact ctgatcatct gaccaaaact catcatgata tgtttactaa aggacaagtc      900

accacaggac agtacaggat gcttgccaaa agaggtggat atgtctgggt tgaaactcaa      960

gcaactgtca tatataacac caagaattct caaccacagt gcattgtatg tgtgaattac     1020

gttgtgagtg gtattattca gcacgacttg attttctccc ttcaacaaac agaatgtgtc     1080

cttaaaccgg ttgaatcttc agatatgaaa atgactcagc tattcaccaa agttgaatca     1140

gaagatacaa gtagcctctt tgacaaactt aagaaggaac ctgatgcttt aactttgctg     1200

gccccagccg ctggagacac aatcatatct ttagattttg gcagcaacga cacagaaact     1260

gatgaccagc aacttgagga agtaccatta tataatgatg taatgctccc ctcacccaac     1320

gaaaaattac agaatataaa tttggcaatg tctccattac ccaccgctga aacgccaaag     1380

ccacttcgaa gtagtgctga ccctgcactc aatcaagaag ttgcattaaa attagaacca     1440

aatccagagt cactggaact ttcttttacc atgccccaga ttcaggatca gacacctagt     1500

ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag tgaatattgt     1560

ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga aaaacttttt     1620

gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt agacttggag     1680

atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt cgatcagttg     1740

tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag cacagttaca     1800

gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac cactgccacc     1860

actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat attgattgca     1920

tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc accatataga     1980

gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat agaacagaca     2040

gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca aagaactaca     2100

gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca gagaaagcga     2160

aaaatggaac atgatggttc actttttcaa gcagtaggaa ttggaacatt attacagcag     2220

ccagacgatc atgcagctac tacatcactt tcttggaaac gtgtaaaagg atgcaaatct     2280

agtgaacaga atggaatgga gcaaaagaca attattttaa taccctctga tttagcatgt     2340

agactgctgg ggcaatcaat ggatgaaagt ggattaccac agctgaccag ttatgattgt     2400

gaagttaatg ctcctataca aggcagcaga aacctactgc agggtgaaga attactcaga     2460

gctttggatc aagttaactg a                                               2481


<210>  4
<211>  3159
<212>  DNA
<213>  Homo sapiens

<400>  4
atggcagctg cttaccttga ccccaacttg aatcacacac caaattcgag tactaagact       60

cacctgggta ctggtatgga acgttctcct ggtgcaatgg agcgagtatt aaaggtcttt      120

cattattttg aaagcaatag tgagccaacc acctgggcca gtattatcag gcatggagat      180

gctactgatg tcaggggcat cattcagaag atagtggaca gtcacaaagt aaagcatgtg      240

gcctgctatg gattccgcct cagtcacctg cggtcagagg aggttcactg gcttcacgtg      300

gatatgggcg tctccagtgt gagggagaag tatgagcttg ctcacccacc agaggagtgg      360

aaatatgaat tgagaattcg ttatttgcca aaaggatttc taaaccagtt tactgaagat      420

aagccaactt tgaatttctt ctatcaacag gtgaagagcg attatatgtt agagatagct      480

gatcaagtgg accaggaaat tgctttgaag ttgggttgtc tagaaatacg gcgatcatac      540

tgggagatgc ggggcaatgc actagaaaag aagtctaact atgaagtatt agaaaaagat      600

gttggtttaa agcgattttt tcctaagagt ttactggatt ctgtcaaggc caaaacacta      660

agaaaactga tccaacaaac atttagacaa tttgccaacc ttaatagaga agaaagtatt      720

ctgaaattct ttgagatcct gtctccagtc tacagatttg ataaggaatg cttcaagtgt      780

gctcttggtt caagctggat tatttcagtg gaactggcaa tcggcccaga agaaggaatc      840

agttacctaa cggacaaggg ctgcaatccc acacatcttg ctgacttcac tcaagtgcaa      900

accattcagt attcaaacag tgaagacaag gacagaaaag gaatgctaca actaaaaata      960

gcaggtgcac ccgagcctct gacagtgacg gcaccatccc taaccattgc ggagaatatg     1020

gctgacctaa tagatgggta ctgccggctg gtgaatggaa cctcgcagtc atttatcatc     1080

agacctcaga aagaaggtga acgggctttg ccatcaatac caaagttggc caacagcgaa     1140

aagcaaggca tgcggacaca cgccgtctct gtgtcagaaa cagatgatta tgctgagatt     1200

atagatgaag aagatactta caccatgccc tcaaccaggg attatgagat tcaaagagaa     1260

agaatagaac ttggacgatg tattggagaa ggccaatttg gagatgtaca tcaaggcatt     1320

tatatgagtc cagagaatcc agctttggcg gttgcaatta aaacatgtaa aaactgtact     1380

tcggacagcg tgagagagaa atttcttcaa gaagccttaa caatgcgtca gtttgaccat     1440

cctcatattg tgaagctgat tggagtcatc acagagaatc ctgtctggat aatcatggag     1500

ctgtgcacac ttggagagct gaggtcattt ttgcaagtaa ggaaatacag tttggatcta     1560

gcatctttga tcctgtatgc ctatcagctt agtacagctc ttgcatatct agagagcaaa     1620

agatttgtac acagggacat tgctgctcgg aatgttctgg tgtcctcaaa tgattgtgta     1680

aaattaggag actttggatt atcccgatat atggaagata gtacttacta caaagcttcc     1740

aaaggaaaat tgcctattaa atggatggct ccagagtcaa tcaattttcg acgttttacc     1800

tcagctagtg acgtatggat gtttggtgtg tgtatgtggg agatactgat gcatggtgtg     1860

aagccttttc aaggagtgaa gaacaatgat gtaatcggtc gaattgaaaa tggggaaaga     1920

ttaccaatgc ctccaaattg tcctcctacc ctctacagcc ttatgacgaa atgctgggcc     1980

tatgacccca gcaggcggcc caggtttact gaacttaaag ctcagctcag cacaatcctg     2040

gaggaagaga aggctcagca agaagagcgc atgaggatgg agtccagaag acaggccaca     2100

gtgtcctggg actccggagg gtctgatgaa gcaccgccca agcccagcag accgggttat     2160

cccagtccga ggtccagcga aggattttat cccagcccac agcacatggt acaaaccaat     2220

cattaccagg tttctggcta ccctggttca catggaatca cagccatggc tggcagcatc     2280

tatccaggtc aggcatctct tttggaccaa acagattcat ggaatcatag acctcaggag     2340

atagcaatgt ggcagcccaa tgtggaggac tctacagtat tggacctgcg agggattggg     2400

caagtgttgc caacccatct gatggaagag cgtctaatcc gacagcaaca ggaaatggaa     2460

gaagatcagc gctggctgga aaaagaggaa agatttctga aacctgatgt gagactctct     2520

cgaggcagta ttgacaggga ggatggaagt cttcagggtc cgattggaaa ccaacatata     2580

tatcagcctg tgggtaaacc agatcctgca gctccaccaa agaaaccgcc tcgccctgga     2640

gctcccggtc atctgggaag ccttgccagc ctcagcagcc ctgctgacag ctacaacgag     2700

ggtgtcaagc ttcagcccca ggaaatcagc ccccctccta ctgccaacct ggaccggtcg     2760

aatgataagg tgtacgagaa tgtgacgggc ctggtgaaag ctgtcatcga gatgtccagt     2820

aaaatccagc cagccccacc agaggagtat gtccctatgg tgaaggaagt cggcttggcc     2880

ctgaggacat tattggccac tgtggatgag accattcccc tcctaccagc cagcacccac     2940

cgagagattg agatggcaca gaagctattg aactctgacc tgggtgagct catcaacaag     3000

atgaaactgg cccagcagta tgtcatgacc agcctccagc aagagtacaa aaagcaaatg     3060

ctgactgctg ctcacgccct ggctgtggat gccaaaaact tactcgatgt cattgaccaa     3120

gcaagactga aaatgcttgg gcagacgaga ccacactga                            3159


<210>  5
<211>  1380
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctcccc tgtgccccag cccctggctc cctctgttga tcccggcccc tgctccaggc       60

ctcactgtgc aactgctgct gtcactgctg cttctggtgc ctgtccatcc ccagaggttg      120

ccccggatgc aggaggattc ccccttggga ggaggctctt ctggggaaga tgacccactg      180

ggcgaggagg atctgcccag tgaagaggat tcacccagag aggaggatcc acccggagag      240

gaggatctac ctggagagga ggatctacct ggagaggagg atctacctga agttaagcct      300

aaatcagaag aagagggctc cctgaagtta gaggatctac ctactgttga ggctcctgga      360

gatcctcaag aaccccagaa taatgcccac agggacaaag aaggggatga ccagagtcat      420

tggcgctatg gaggcgaccc gccctggccc cgggtgtccc cagcctgcgc gggccgcttc      480

cagtccccgg tggatatccg cccccagctc gccgccttct gcccggccct gcgccccctg      540

gaactcctgg gcttccagct cccgccgctc ccagaactgc gcctgcgcaa caatggccac      600

agtgtgcaac tgaccctgcc tcctgggcta gagatggctc tgggtcccgg gcgggagtac      660

cgggctctgc agctgcatct gcactggggg gctgcaggtc gtccgggctc ggagcacact      720

gtggaaggcc accgtttccc tgccgagatc cacgtggttc acctcagcac cgcctttgcc      780

agagttgacg aggccttggg gcgcccggga ggcctggccg tgttggccgc ctttctggag      840

gagggcccgg aagaaaacag tgcctatgag cagttgctgt ctcgcttgga agaaatcgct      900

gaggaaggct cagagactca ggtcccagga ctggacatat ctgcactcct gccctctgac      960

ttcagccgct acttccaata tgaggggtct ctgactacac cgccctgtgc ccagggtgtc     1020

atctggactg tgtttaacca gacagtgatg ctgagtgcta agcagctcca caccctctct     1080

gacaccctgt ggggacctgg tgactctcgg ctacagctga acttccgagc gacgcagcct     1140

ttgaatgggc gagtgattga ggcctccttc cctgctggag tggacagcag tcctcgggct     1200

gctgagccag tccagctgaa ttcctgcctg gctgctggtg acatcctagc cctggttttt     1260

ggcctccttt ttgctgtcac cagcgtcgcg ttccttgtgc agatgagaag gcagcacaga     1320

aggggaacca aagggggtgt gagctaccgc ccagcagagg tagccgagac tggagcctag     1380


<210>  6
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  6
atgggtagca acaagagcaa gcccaaggat gccagccagc ggcgccgcag cctggagccc       60

gccgagaacg tgcacggcgc tggcgggggc gctttccccg cctcgcagac ccccagcaag      120

ccagcctcgg ccgacggcca ccgcggcccc agcgcggcct tcgcccccgc ggccgccgag      180

cccaagctgt tcggaggctt caactcctcg gacaccgtca cctccccgca gagggcgggc      240

ccgctggccg gtggagtgac cacctttgtg gccctctatg actatgagtc taggacggag      300

acagacctgt ccttcaagaa aggcgagcgg ctccagattg tcaacaacac agagggagac      360

tggtggctgg cccactcgct cagcacagga cagacaggct acatccccag caactacgtg      420

gcgccctccg actccatcca ggctgaggag tggtattttg gcaagatcac cagacgggag      480

tcagagcggt tactgctcaa tgcagagaac ccgagaggga ccttcctcgt gcgagaaagt      540

gagaccacga aaggtgccta ctgcctctca gtgtctgact tcgacaacgc caagggcctc      600

aacgtgaagc actacaagat ccgcaagctg gacagcggcg gcttctacat cacctcccgc      660

acccagttca acagcctgca gcagctggtg gcctactact ccaaacacgc cgatggcctg      720

tgccaccgcc tcaccaccgt gtgccccacg tccaagccgc agactcaggg cctggccaag      780

gatgcctggg agatccctcg ggagtcgctg cggctggagg tcaagctggg ccagggctgc      840

tttggcgagg tgtggatggg gacctggaac ggtaccacca gggtggccat caaaaccctg      900

aagcctggca cgatgtctcc agaggccttc ctgcaggagg cccaggtcat gaagaagctg      960

aggcatgaga agctggtgca gttgtatgct gtggtttcag aggagcccat ttacatcgtc     1020

acggagtaca tgagcaaggg gagtttgctg gactttctca agggggagac aggcaagtac     1080

ctgcggctgc ctcagctggt ggacatggct gctcagatcg cctcaggcat ggcgtacgtg     1140

gagcggatga actacgtcca ccgggacctt cgtgcagcca acatcctggt gggagagaac     1200

ctggtgtgca aagtggccga ctttgggctg gctcggctca ttgaagacaa tgagtacacg     1260

gcgcggcaag gtgccaaatt ccccatcaag tggacggctc cagaagctgc cctctatggc     1320

cgcttcacca tcaagtcgga cgtgtggtcc ttcgggatcc tgctgactga gctcaccaca     1380

aagggacggg tgccctaccc tgggatggtg aaccgcgagg tgctggacca ggtggagcgg     1440

ggctaccgga tgccctgccc gccggagtgt cccgagtccc tgcacgacct catgtgccag     1500

tgctggcgga aggagcctga ggagcggccc accttcgagt acctgcaggc cttcctggag     1560

gactacttca cgtccaccga gccccagtac cagcccgggg agaacctcta g              1611


<210>  7
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu 
1               5                   10                  15      


Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu 
            20                  25                  30          


Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu 
        35                  40                  45              


Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg 
    50                  55                  60                  


Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser 
65                  70                  75                  80  


Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln 
                85                  90                  95      


Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr 
            100                 105                 110         


Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu 
        115                 120                 125             


Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly 
    130                 135                 140                 


Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu 
145                 150                 155                 160 


Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg 
                165                 170                 175     


Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro 
            180                 185                 190         


Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His 
        195                 200                 205             


Gln Arg Met Gly Asp 
    210             


<210>  8
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                325                 330                 335     


Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
            340                 345                 350         


Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
        355                 360                 365             


Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
    370                 375                 380                 


Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
385                 390                 395                 400 


His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                405                 410                 415     


Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
            420                 425                 430         


Ser Asn Thr 
        435 


<210>  9
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210>  10
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Ser Ala Asp Cys Asn Leu Cys Leu Pro Glu Tyr Asp Arg Tyr 
1               5                   10                  15      


Leu Ala Ser Ser Lys Ile Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu 
            20                  25                  30          


Asn His Thr Pro Asn Ser Ser Thr Lys Thr His Leu Gly Thr Gly Met 
        35                  40                  45              


Glu Arg Ser Pro Gly Ala Met Glu Arg Val Leu Lys Val Phe His Tyr 
    50                  55                  60                  


Phe Glu Ser Asn Ser Glu Pro Thr Thr Trp Ala Ser Ile Ile Arg His 
65                  70                  75                  80  


Gly Asp Ala Thr Asp Val Arg Gly Ile Ile Gln Lys Ile Val Asp Ser 
                85                  90                  95      


His Lys Val Lys His Val Ala Cys Tyr Gly Phe Arg Leu Ser His Leu 
            100                 105                 110         


Arg Ser Glu Glu Val His Trp Leu His Val Asp Met Gly Val Ser Ser 
        115                 120                 125             


Val Arg Glu Lys Tyr Glu Leu Ala His Pro Pro Glu Glu Trp Lys Tyr 
    130                 135                 140                 


Glu Leu Arg Ile Arg Tyr Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr 
145                 150                 155                 160 


Glu Asp Lys Pro Thr Leu Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp 
                165                 170                 175     


Tyr Met Leu Glu Ile Ala Asp Gln Val Asp Gln Glu Ile Ala Leu Lys 
            180                 185                 190         


Leu Gly Cys Leu Glu Ile Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn 
        195                 200                 205             


Ala Leu Glu Lys Lys Ser Asn Tyr Glu Val Leu Glu Lys Asp Val Gly 
    210                 215                 220                 


Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp Ser Val Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu 
                245                 250                 255     


Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu Ile Leu Ser Pro Val 
            260                 265                 270         


Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp 
        275                 280                 285             


Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr 
    290                 295                 300                 


Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu Ala Asp Phe Thr Gln 
305                 310                 315                 320 


Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly 
                325                 330                 335     


Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu Pro Leu Thr Val Thr 
            340                 345                 350         


Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala Asp Leu Ile Asp Gly 
        355                 360                 365             


Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro 
    370                 375                 380                 


Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn 
385                 390                 395                 400 


Ser Glu Lys Gln Gly Met Arg Thr His Ala Val Ser Val Ser Glu Thr 
                405                 410                 415     


Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro 
            420                 425                 430         


Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg 
        435                 440                 445             


Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His Gln Gly Ile Tyr Met 
    450                 455                 460                 


Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile Lys Thr Cys Lys Asn 
465                 470                 475                 480 


Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr 
                485                 490                 495     


Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly Val Ile 
            500                 505                 510         


Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu Gly Glu 
        515                 520                 525             


Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser 
    530                 535                 540                 


Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu 
545                 550                 555                 560 


Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val Leu Val 
                565                 570                 575     


Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr 
            580                 585                 590         


Met Glu Asp Ser Thr Tyr Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile 
        595                 600                 605             


Lys Trp Met Ala Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala 
    610                 615                 620                 


Ser Asp Val Trp Met Phe Gly Val Cys Met Trp Glu Ile Leu Met His 
625                 630                 635                 640 


Gly Val Lys Pro Phe Gln Gly Val Lys Asn Asn Asp Val Ile Gly Arg 
                645                 650                 655     


Ile Glu Asn Gly Glu Arg Leu Pro Met Pro Pro Asn Cys Pro Pro Thr 
            660                 665                 670         


Leu Tyr Ser Leu Met Thr Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg 
        675                 680                 685             


Pro Arg Phe Thr Glu Leu Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu 
    690                 695                 700                 


Glu Lys Ala Gln Gln Glu Glu Arg Met Arg Met Glu Ser Arg Arg Gln 
705                 710                 715                 720 


Ala Thr Val Ser Trp Asp Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys 
                725                 730                 735     


Pro Ser Arg Pro Gly Tyr Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr 
            740                 745                 750         


Pro Ser Pro Gln His Met Val Gln Thr Asn His Tyr Gln Val Ser Gly 
        755                 760                 765             


Tyr Pro Gly Ser His Gly Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro 
    770                 775                 780                 


Gly Gln Ala Ser Leu Leu Asp Gln Thr Asp Ser Trp Asn His Arg Pro 
785                 790                 795                 800 


Gln Glu Ile Ala Met Trp Gln Pro Asn Val Glu Asp Ser Thr Val Leu 
                805                 810                 815     


Asp Leu Arg Gly Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu 
            820                 825                 830         


Arg Leu Ile Arg Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu 
        835                 840                 845             


Glu Lys Glu Glu Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly 
    850                 855                 860                 


Ser Ile Asp Arg Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln 
865                 870                 875                 880 


His Ile Tyr Gln Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys 
                885                 890                 895     


Lys Pro Pro Arg Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser 
            900                 905                 910         


Leu Ser Ser Pro Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro 
        915                 920                 925             


Gln Glu Ile Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp 
    930                 935                 940                 


Lys Val Tyr Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met 
945                 950                 955                 960 


Ser Ser Lys Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val 
                965                 970                 975     


Lys Glu Val Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu 
            980                 985                 990         


Thr Ile Pro Leu Leu Pro Ala Ser  Thr His Arg Glu Ile  Glu Met Ala 
        995                 1000                 1005             


Gln Lys  Leu Leu Asn Ser Asp  Leu Gly Glu Leu Ile  Asn Lys Met 
    1010                 1015                 1020             


Lys Leu  Ala Gln Gln Tyr Val  Met Thr Ser Leu Gln  Gln Glu Tyr 
    1025                 1030                 1035             


Lys Lys  Gln Met Leu Thr Ala  Ala His Ala Leu Ala  Val Asp Ala 
    1040                 1045                 1050             


Lys Asn  Leu Leu Asp Val Ile  Asp Gln Ala Arg Leu  Lys Met Leu 
    1055                 1060                 1065             


Gly Gln  Thr Arg Pro His 
    1070                 


<210>  11
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  12
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


