                         SEQUENCE LISTING

<110>  CSIR,IN
 
<120>  WDR13 AS ANOVEL BIOMARKER USEFUL FOR TREATING DIABETES AND CANCER

<130>  2696DEL2010

<160>  24    

<170>  PatentIn version 3.5


<210>  1
<211>  11558
<212>  DNA
<213>  Wdr13 complete gene sequence 
 

<400>  1
ctgcagagcc atctcaccag cccccaaata catttttaaa acacattgat tatagtgttc       60

tttatgattt aaaaaaatgt gaaaataaag tgtggctcac agatgtgagg gggtgctagt      120

cctctgtgct gtggactcgc atctataaag gagagactgg aaaaggaccc acaacattcc      180

tattaagatt taattggctg gatgtggtga tgaataatgt agtcctggct acttggaagg      240

ttaagacggg aggatcacaa agtctaggcc agtctggaaa atttagcaag aaagtctcaa      300

aacaaaaaac tggagcctgg tgacaagttt ttaattccag cactggggag ataaaaacag      360

aaggaagggt gagaaattca aggccactct caactgcgta tccagctgaa ggtcagcctg      420

gcctaattaa gactttgtct caaacaaaaa acaataaagg acacttgtga tgatccaata      480

cctaggcagt agagacagga ggaccagctc agttatcctc tgtaacataa tgagttggaa      540

ggcagcctgg gttacatgac acgtcgtttt taaaacaaaa ggtactggct ggcctaggat      600

gtctaaggcc ctgggtccta tcccctgtac aataagaaat tagattaatg catgcaagct      660

acttaaacag tgtccagcac tctatccgat gaatacttag ggtcttgtta aggctacatg      720

tttgtgccaa gaaataattt attcttttta agctatattg caggggatat tttaaaacac      780

tgatagggtg acagaggaga taccaatagg attcacttac ctatttttta ttcctcactt      840

caggcaacct aaaaagacat tatttagttg atggttagtt ttttgtcagc ttgacacaag      900

ttatggtcac ttggaaagaa ggacccttaa ctgagtctct atcagactgt cctatgggga      960

tacctgcagg ggcattttct tgcctaataa ctgttgtggg caggtgagtc tgggttgaag     1020

aagcaggcta cagcaagcct tgagaagcaa gccgataagc agtgttcctc catgatctct     1080

gcttcagttc ctggcttgat tttcagccct gagctatctc catcctgctt gcttgctttt     1140

ttttcttttc tttttttgac acagggtttc tctgtatagc cctggctgtc ctggaactca     1200

ctttgtagac caggctggcc ttgaactcag aaatccgcct gcctctgcct cccaagtgct     1260

gggattaaag gcgtgcgcca ccacgcccgg cgcttgcttg ctatttaaag tatgtagtcc     1320

aggatgtagt cctggatttg actacatagg ccagactgca ttcgaactca tgatcctcct     1380

gccactctat cccctacatc accctcttct aggattacca ttatgctaga ctaaacatct     1440

tgaatttcaa ccttggaatt tctgtttttg acactgagag gaatactcaa gatacaaatt     1500

ctagcttaag gtgaatataa cagacgattg ggatactttc ctttccttag gtcacagccc     1560

caaagcttgt tttcctaatt gcatattttt attaagatac tcaagtttcc taggggtaac     1620

cattcaagtc cagttagtcc cagtgaagat acacatggat tcttcccatc gcataggtgt     1680

ttagagattc atcactgcgc taggaactag agaatgttcc aggagtcagt ctctgcatat     1740

attttatttg cctggccaaa tgtgtgctgc taagaagcag cctaaaccac tttcatgaga     1800

aagtcttatt tctgattttt agctagtggt tggcacacgc attcttgtcc ttctgatcac     1860

agtacattat ccctgtgtat acaaaaggtg tcaagaggga aatgaataga actcaagggg     1920

tggagcctcg gtccttgtat gggaaactac agtcctttaa tgcgcctgcg aggctcccac     1980

gccccgggaa aggttcctat cgatttgctc tgtgctccgc agctctttct cgttgcaggc     2040

agccatcttg cctggagctt gagacaggga gaagagagag aaggaaccgg tgacactggg     2100

ctcagggtcg ccgggggggg ggggcgcctc aagagctagg ggtagccccg gaggtggtcc     2160

tggatcctga gctatgctct aggactagaa aagggaaggc ggagggcaga aggcttgatg     2220

ggtggggaat gtcaaacaag acttgctatg ggggggaggg gcgttgctac ggcaactgga     2280

gagggcgggg tcatgtctga actgctgctg tgagtcaccg gagtgctgcc caggaaaggc     2340

agggctgggg tgatgaccac gctaacgacc cagtgggatt tcgcgacatc acctgtgtgg     2400

agggacttcg tgtctatggc aactgtcacc tggtgggcgg aactagattt tctctgcctg     2460

ggacgctgac attccaagcc cttgccctgc aggctcccgc aggcagacaa accaaagaag     2520

gaagccaggg aatggccgcg gtgtggcagc aagtattagc agtggacgcg aggtgaggcg     2580

tggggttgga gcccatggga gaggaactta ctgtggtgca tgagcaatgg cgataagtgc     2640

agctgggcgg agaagttggc tggtgcggct gcgtgagcat gcgcagtagc ttggtgtggg     2700

atagtcctgc ggttaagtgg cctgggctgg agccggttct aaagagcatg ctgggaaaat     2760

gcggtttgaa atggacatgc gcagactgtc tttgagtggg tagtggaagt caggctggtg     2820

acttcctatc tagtccctca ttgcttatcc tcttccccaa cttttctcga tatcactacc     2880

ctactattat tacaattgct accccatact aacctctacc gttatctgac cctaacctcc     2940

attgttgtac attaccaatc tgacgtatgt catcatgcta gactgatatt acagctggcc     3000

cagactgacc ccaacagagc tgcaaattga ctatattgtc gctagagtga tcttttcatc     3060

ataaccacta attattgcat aattgccccc catcacaatc ccaagagaaa tccccctttg     3120

ctgctcttgt tcactcttac catcccagtc actgccaaac cttgtaccac ctcgagctga     3180

tttattccct ctgtcctgtg cctgctgcct gccctgcctc ctggacccca caggtacaac     3240

gcctaccgta caccaacgtt tccacagttt cggacccagt atatccgccg gcgcagccag     3300

ctgcttcggg agaatgccaa agctggtcac cccccagcat tgcgtcggca gtacctgagg     3360

ctacggggcc agctattggg ccaacggtac gggccactct cagaaccagg cagtgctcgt     3420

gcctatagca acagcattgt ccgcagcagc cgaacaaccc ttgatcgaat ggaggtgagc     3480

tcctagctgc accacccgcc atgtatctcc cctgcctctg tagtcaccat agtttttggt     3540

caaacatcag tgatgtacaa agtactgttc caggtcagta gaggactaaa agggaataga     3600

gaagccaagt caatgaacat tgataagcag acagtgaatt agataaacac agagcaggta     3660

agactgatga gttgataatt taccatggta tagtaagcaa tgcaaagata gtaacataca     3720

acagacttaa aaagcaaaaa ggaacacaag tgtttggtgc atggatatag ttcagtaact     3780

agcgtgattg cctagtatgt atgagactga tggttctatt ctcaacatgg ccaagaagaa     3840

tgaaaagtca ctgctttgag ctaaaggagg gagctgtgct taatagggaa gacttgtctg     3900

gggagggaac accgaaacct gacagaagtg agagactgat ttgagtgctt ctctgggaag     3960

aaagtagtca tcccttgtga ggaaagcatg tatgtactaa ggatgtttgg aacaggaaag     4020

gaaggacaga aacaaaggca ctagtgaaga aactgttgaa accacacaag tgagcagtga     4080

cagtggtggc tggcgccatg tgtggtgacg agaagtcagg ccccagattt aagctcatct     4140

cagagattaa tttctattta tttatttatt tatttattat atgtaagtac actgtagctg     4200

tcctcagaca ctccagaaga gggagtcaga tctcgttaca gatggttgtg agccaccatg     4260

tggttgctgg gatttgaact cctgaccttc ggaaaagcag ttgggtgctt ttacccactg     4320

agccatctca ccagcccaat ttctcttctt tttgagacag gatctcaccc agactggcct     4380

caaattcact gtgtagccaa ggcaggcctt gagcacggtg accttcctgc ctcagtttcc     4440

caaagtgctg gaattagagg tatgcaccat ccccaaccct cttctctttg caggactttg     4500

aagatgaccc cagagccctg ggggctcgag gacaccgccg atctgtcagc cgaggttcct     4560

accagctgca ggcacaaatg aaccgtgcag tctatgagga caggtacata ccagaggcag     4620

gcagggggtg gagattcacc aggaggagag gggccctggg acgtggcagt ctgaacaccc     4680

atacctacct cctatcaccc cttcccacct cctgttgggg ctcaggcctc ctggcagtgt     4740

ggtacccacg tcggtggcag aggcaagtcg ggccatggcc ggggacacgt cgctgagtga     4800

gaactatgcc tttgcaggca tgtaccatgt ttttgaccaa cacgtggatg aggcaggtga     4860

gctaatgggt ggtagggccc atcaccaaac atttgttcaa acaactaccc aaggcatcct     4920

tttctagaat gcaaggcctc tgacaccata cctcagaagg aggaaatagc actgataaaa     4980

cctttagcaa agccaagcag tgatggcgca cacctctaat tccagcactc gggaggcagg     5040

tggatttgag ttcgaggcca gcctggtcta cagagtgagt tccaggacag ccagggctac     5100

acagagaaac cctgtctcgg aaaaagaaaa agaaaaaaaa aacctttagc aaatgcaaaa     5160

gccctcttgc aaagtggtcc aagaaggttt tggtaatgta ggtactggaa agagctacac     5220

aaacccaaga gagtcctttg tagcaggctg cctgagtgtt tgagtctctt agaagagttc     5280

aaaacctttg ctgatggtaa ctcccttgta gaggccacag tgggccacaa tgtgtggatg     5340

gttttgcaaa ctcctgagag cttgattatt gtaaagtact caataagaca gtacaatttt     5400

tgcattgcaa aagacttttg tagtcctcaa agtgtctgct aagatttaga gagcattttg     5460

gcagtaggcc ttctaagatt acaactgcct ttgtcggcca aggaaagtcc tttgttgagg     5520

ctactgttcc ttgtgctcag tgaatgtgtt gactcccaca aatggctcct tggcatttgc     5580

agtcccaagg gtgcgcttcg ccaatgacga ccggcaccgc ctggcctgct gctccctgga     5640

cggcagcatc tccctgtgcc agctggtgcc tgccccaccc actgtgctcc atgtgctacg     5700

gggccataca cgtggcgtct cggacttcgc ctggtccctc tccaatgaca tccttgtgtc     5760

cacctccctc gatgccacca tgcgcatctg ggcctccgag gacggccgct gcatccgtga     5820

gatccctgac cctgatggcg ccgaattgct ctgctgcacc ttccagccag tcaacaacaa     5880

cctcactgtg gtcaggctcc aggacacctg ctcaccaagg gcgggcatgc tgggtctgga     5940

gggctgtcct ggggcactag agaataaggc ttaatacccc caagtcctat cccagccgtc     6000

ctgtggtcag actcaaaggg aaagagacca acgaaaagca cagtttgtgg tctggaatgg     6060

ccttgctgtg tagacttgtg tgtagactcc cgagctggga tggaggggtt gtctcctagc     6120

cctgggattc cactggtccc atccaccaca gtctcacagt tttctgtcta caggggctgc     6180

tgctatgggg caggatgatg aggctgaaag ctcatctagt ctgtcagtgg cagccccact     6240

gttgtcagac tccaggacag actggccaga gggcagagga aggacatgga aagtctggca     6300

tgacctgggg ggtagggagt tgaaatatag gggaacaaca ggccatgagt gagctagcgc     6360

ttggggctct gtctctttgt aatggtagca gctcatgggc ttcaggaggg gacagtccag     6420

ggtataaggg aaagatgtaa aggtgtcaca aggcgaggtt ttcagactca gagactaaga     6480

ctgctttggt ctcgtgagac caactattgt gggcattttg agggcacagc taaggagtag     6540

gaattgtgcc tgggtcacct tctggtatac ctggcctggt cccactgtgt taaacacaaa     6600

ggactagatg gctcagaatg atggtgtatg cctgtcaccc acaggtgggg aacgccaagc     6660

acaacgtgca tgtcatgaac atctccacag gcaagaaagt gaagggtggc tccagcaagc     6720

tcaccggccg cgtcctcgcc ctgtcctttg atgcccctgg tcggctgctc tgggcaggcg     6780

atgaccgcgg cagtgtcttc tcctttctct ttgacatggc cacaggtagg cagaccacag     6840

acttcgggtt cggtacccct ggttttcatt ctcccaggac tcagtccttg tcctccactg     6900

attcaggaaa gctgaccaaa gccaagcgac tagtagtgca tgaaggcagc cctgtaacca     6960

gcatttctgc ccggtcctgg gtcagccgtg aagcacggga cccctctctg ctcatcaatg     7020

cctgcctcaa caagctgcta ctctacaggt gggttcctcc cccagagtgg aacaagaacc     7080

tgtctctgtc acattaattt caccaaggac agaggacctc ataatatgat gaggataggg     7140

tcggagatgt aacttagtgg cagagtgctg atctagctgg tacagagctc tgtgttccat     7200

ccccagaaac acgccacata cacacacaca ctatatatct atatctatgt ctatgtctat     7260

atatttgtgt gtgtatatat atatacacat atatatacat acatatatat atatatatat     7320

atttatatag tgattcctta cctactatat atatatatac tatgcaataa tggtgatatc     7380

aatagcaaca taaataggaa tagcagtaat aagactctac atgaacattg ctatggctag     7440

gtcccattca aagcactttg tatatatcac cttatttaat cttcacaatc agtggtagag     7500

cactcgccta gcatgtataa ggctgtgggt tccactctca acattataac taaagaaaaa     7560

accaccagca cctattcctc tttccttgtt ttgaattttt cacgtgtgtg tgtgtgtgtg     7620

tgtgtatgct tgcataccat ggagcatata cggagggagg tcagaggaca acttgtggca     7680

gtctgttctg ttcttcatgt aggttctagg aatggaagtc aaggaattgg cagccaaggt     7740

tctaggaatt ggcagcctgg cagcgtgtgt ctttatccac ttgagtcatc tctacagttc     7800

cctttcttta tttttgtttc ttttgtctgg gaattgaacc cagaaccttg cacatgctag     7860

taacacacgt caccactgag atatacccac agcctatatt attgtgttga tttgatttgg     7920

ggacagaatt cactcttccc actcgcttct gtcacggtac gattcttcag ctggggtgta     7980

taaaatgata ggcagagctc cttttggaag gtgtgctgct cgcactgggc ataataagct     8040

catgtacagt acttgagagg cggaagcagg ttgatctatg tgaattcaag atgagcctga     8100

cctacctaca tagcaagttt caggttagcc tgaactacac agcaagaccc tgtcctaaaa     8160

taaacaagca aacaaaacct aaggggctgg agagatggct cagcagcagt taagaacact     8220

tgttgctctt tcagacgact gaggttcagt tcccagcagt catgccagct tacacctgtc     8280

tgtaattcca gctccaggaa tctaacccct cttctggcct cttctagtac tatacacacg     8340

tggtgaacag acgcaatgct ggtaaaacag ccatacacat aaagtgaaaa tacataagta     8400

taaagaaaag ttagcgtgat gatacacacc tatgatgcca gcactcaaag gcctgatgca     8460

ggaggatcat tgagtgcagg agctcagact caacttggac aacaaaataa ggctctgtct     8520

ccaaaggaaa aggaaaatcg aaattgtttg tacattgtaa atatctgaga tgcgggattc     8580

agagcgtata ctggcccata actcgtcgtc tcctgaggct gaggctgtgc cctgaccttc     8640

tcttttgctt tctcttcaga gtggtggaca acgaaggggc gctacagctg aagagaagct     8700

tccccattga acagagttcc caccctgtac gcagtatctt ctgccccctc atgtccttcc     8760

gccagggggc ctgtgtgggt aagtacttag gctctgagga cctgcagcca gcctggttcc     8820

aacagcatga cacccgtgat ttcctgggcc ctgtggtctc ttgtgcccta acagtgttat     8880

gcctagaggc tttaaacatg gagccacaaa cagtttgaga acgccacagc tgagacacag     8940

agcccgcact gtcctcaaac ctcacatact cctcaccgaa ccaaaggagg cagatgagct     9000

cctatctagg gatggttcct tgtagactac cccaagctac ctgaggccct cacacctcac     9060

ataacctcaa gacttcatag tgggggtgtc acctagcccc ctgatcgcct ttccctctca     9120

tccggacagt gacaggcagt gaagatatgt gcgttcactt ctttgacgtg gagcgggcag     9180

ccaaggctgc tgttaacaag ctgcagggcc acagcgcgcc cgtgcttgac gtcagcttca     9240

actgtgacga gagtctgctg gcctccagtg atgccagtgg catggtcatc gtctggagac     9300

gagagcaaaa gtagggttct gtcaccctgt gctgcccact gatccctcct ccttcactcc     9360

agtcttgcgt tataaattaa attcctgtgg ttgtgttgaa gggctctcag ctctcccacc     9420

aggaggcagt agggagctct caggcctcca gtggagtggg gaccagttcc tcgattgtgc     9480

agtgatgtgc tcatccattc aacaagcact tgctgagcat ctgctgtgat gtatcacgta     9540

ggcatgcagt cagtagaagg agggagggta ccaactgtgg tcaggagctg ttctgggaag     9600

tagggataca gctatggctt caactgaaat tcctacccct gtgggctggc atcccagcag     9660

aggcaagcat acaggagaca gacgttctga gctgttctgg gaagtaggga tacagctgtg     9720

gcttcaactg acagaaattc ctacccctgt gggctggcat cccaatagag gcaagcacat     9780

gggagacgaa agtacagcca ttccttggtg tagaatttgc tttataattt ttcaacttta     9840

taaatttttg accttccagt ggtagcgaac cacacgcata tacccagttc tggttttctc     9900

ctttcagtat ggtgttcagt aaattatgtg agctagtcac tttgttataa aatagacttt     9960

gcattaggta agtttgccta actgtagaat aatgtcagcg ttgtgggcac atttaaggta    10020

ggtgacacta agctagggtg ttcggtaggt taggtatatt tatgcatttt caacataaga    10080

cagttcaaga cagatttgtt ggggtctaac cccgtgtgat gaagtcacat ctgtatataa    10140

tagagttaaa gatgagtgct aggaagaaaa gcaaagggcc agatgagctt gcacaaaagg    10200

gaggggcaaa gtcatcagga agagtgttcc caaccagatg acagttttaa agatctgagt    10260

gaaatagagc ctggaataat gtgattgggc ggagtgtatg agatgatggg agacaggtct    10320

ttgggacatc ttgggccata gcaaggaagg aagctttcct tattccctga gtgaggaagg    10380

tgaggaaggc tcagacagca gtagggaaat taggtgcaga atgttaagtt caaccacggg    10440

gctttcacca ggttaggttg tcaaactccc caacattggc agctactgtt tgggtggacc    10500

ccacacttgc ctgtgcgttg agttgtgtcc cacaagcagt gagcagaagt gtcgagttct    10560

tggagctaga ttagcatgca tacagccatg aactctgggg ctgagccaca gttcctgctg    10620

tggggtggaa gaaacagaaa atctctaagc tcacccctgt ctcctgccat gtctatctgg    10680

ggcccttatt tcagtcctgg acctgctcag agaccaaata ctaatgttca ttattgagta    10740

ttggcaagga gataaattac taaatgactc ttggtaatta ggtcatgacg aaatgtgaag    10800

gtttgaagaa tcaccaggag ttcttgcagc tcccatatgc tactacattt gtagcaattg    10860

gaactttggc taacatcctg gaaccgctga gtcttgccaa cctggtgatc tatagaacta    10920

acagcagctc tttgaggaaa aaagatgatt tcctatttgt ttcgtttctt gtttaagagt    10980

atggtcactt ccagccaaaa catttctgac tccatcagtc agattttagg caaatggtta    11040

ttagattgga atgttagtga gctggactgg tcattgtagt caagatcata tatgtgtgcc    11100

aacatcccta atccagcttc agggtcagtg atttttctat gaggactgta acttactata    11160

gcaaagggtg ccagacagca attaagtgct aatctcttta aagaccctcc caaggttagc    11220

agttcagacc tgtgcactgg ctcttctgta ccaaatggat gcacttattc agccaaggtc    11280

tgggggtagc aacagaattt gggtacataa cagttttctc taactttctc cttttcttca    11340

ctctctccat tttctttaat gagtctggtt tcaggatgat tggtgatgaa tattgtttgc    11400

atgattttgg gggggttcct tgtgcaattt ttgaggtggc agagttgaca ttaaattatc    11460

tactttaaat tatcttggtg acacttttgt ctcacaacct gaaggaaaat aaacactgag    11520

caaacaagaa agaataaaaa ataatgttgc tggttaga                            11558

<210>  2
<211>  6934
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  Wdr13 Targeting Vector with artificially inserted sequences from 
       position 1616 - 2756 in place of partial-intron1, exon 2, intron 
       2 and partial-exon 3 of the Wdr13 gene


<220>
<221>  misc_feature
<222>  (3756)..(3756)
<223>  n is a, c, g, or t

<400>  2
aagcttgttt tcctaattgc atatttttat taagatactc caagtttcct aggggtaacc       60

attcaagtcc agttagtccc agtgaagata cacatggatt cttcccatcg cataggtgtt      120

tagagattca tcactgcgct aggaactaga gaatgttcca ggagtcagtc tctgcatata      180

ttttatttgc ctggccaaat gtgtgctgct aagaagcagc ctaaaccact ttcatgagaa      240

agtcttattt ctgattttta gctagtggtt ggcacacgca ttcttgtcct tctgatcaca      300

gtacattatc cctgtgtata caaaaggtgt caagagggaa atgaatagaa ctcaaggggt      360

ggagcctcgg tccttgtatg ggaaactaca gtcctttaat gcgcctgcga ggctcccacg      420

ccccgggaaa ggttcctatc gatttgctct gtgctccgca gctctttctc gttgcaggca      480

gccatcttgc ctggagcttg agacagggag aagagagaga aggaaccggt gacactgggc      540

tcagggtcgc cggggggggg ggggcgcctc aagagctagg ggtagccccg gaggtggtcc      600

tggatcctga gctatgctct aggactagaa aagggaaggc ggagggcaga aggcttgatg      660

ggtggggaat gtcaaacaag acttgctatg ggggggaggg gcgttgctac ggcaactgga      720

gagggcgggg tcatgtctga actgctgctg tgagtcaccg gagtgctgcc caggaaaggc      780

agggctgggg tgatgaccac gctaacgacc cagtgggatt tcgcgacatc acctgtgtgg      840

agggacttcg tgtctatggc aactgtcacc tggtgggcgg aactagattt tctctgcctg      900

ggacgctgac attccaagcc cttgccctgc aggctcccgc aggcagacaa accaaagaag      960

gaagccaggg aatggccgcg gtgtggcagc aagtattagc agtggacgcg aggtgaggcg     1020

tggggttgga gcccatggga gaggaactta ctgtggtgca tgagcaatgg cgataagtgc     1080

agctgggcgg aaaagttggc tggtgcggct gcgtgagcat gcgcagtagc ttggtgtggg     1140

atagtcctgc ggttaagtgg cctgggctgg agccggttct aaagagcatg ctgggaaaat     1200

gcggtttgaa atggacatgc gcagactgtc tttgagtggg tagtggaagt caggctggtg     1260

acttcctatc tagtccctca ttgcttatcc tcttccccaa cttttctcga tatcactacc     1320

ctactattat tacaattgct accccatact aacctctacc gttatctgac cctaacctcc     1380

attgttgtac attaccaatc tgacgtatgt catcatgcta gactgatatt acagctggcc     1440

cagactgacc ccaacagagc tgcaaattga ctatattgtc gctagagtga tcttttcatc     1500

ataaccacta attattgcat aattgccccc catcacaatc ccaagagaaa tccccctttg     1560

ctgctcttgt tcactcttac catcccagtc actgccaaac cttgtaccac ctcgagcagt     1620

gtggttttca agaggaagca aaaagcctct ccacccaggc ctggaatgtt tccacccaat     1680

gtcgagcagt gtggttttgc aagaggaagc aaaaagcctc tccacccagg cctggaatgt     1740

ttccacccaa tgtcgagcaa accccgccca gcgtcttgtc attggcgaat tcgaacacgc     1800

agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg acgcgtgtgg     1860

cctcgaacac cgagcgaccc tgcagccaat atgggatcgg ccattgaaca agatggattg     1920

cacgcaggtt ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag     1980

acaatcggct gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt     2040

tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta     2100

tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg     2160

ggaagggact ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt     2220

gctcctgccg agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat     2280

ccggctacct gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg     2340

atggaagccg gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca     2400

gccgaactgt tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc     2460

catggcgatg cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc     2520

gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat     2580

attgctgaag agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc     2640

gctcccgatt cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgaggggat     2700

cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttcg gatccgtcga     2760

ggacaccgcc gatctgtcag ccgaggttcc taccagctgc aggcacaaat gaaccgtgca     2820

gtctatgagg acaggtacat accagaggca ggcagggggt ggagattcac caggaggaga     2880

ggggccctgg gacgtggcag tctgaacacc catacctacc tcctatcacc ccttcccacc     2940

tcctgttggg gctcaggcct cctggcagtg tggtacccac gtcggtggca gaggcaagtc     3000

gggccatggc cggggacacg tcgctgagtg agaactatgc ctttgcaggc atgtaccatg     3060

tttttgacca acacgtggat gaggcaggtg agctaatggg tggtagggcc catcaccaaa     3120

catttgttca aacaactacc caaggcatcc ttttctagat ctagaatgca aggcctctga     3180

caccatacct cagaaggagg aaatagcact gataaaacct ttagcaaagc caagcagtga     3240

tggcgcacac ctctaattcc agcactcggg aggcaggtgg atttgagttc gaggccagcc     3300

tggtctacag agtgagttcc aggacagcca gggctacaca gagaaaccct gtctcggaaa     3360

aagaaaaaga aaaaaaaaac ctttagcaaa tgcaaaagcc ctcttgcaaa gtggtccaag     3420

aaggttttgg taatgtaggt actggaaaga gctacacaaa cccaagagag tcctttgtag     3480

caggctgcct gagtgtttga gtctcttaga agagttcaaa acctttgctg atggtaactc     3540

ccttgtagag gccacagtgg gccacaatgt gtggatggtt ttgcaaactc ctgagagctt     3600

gattattgta aagtactcaa taagacagta caatttttgc attgcaaaag acttttgtag     3660

tcctcaaagt gtctgctaag atttagagag cattttggca gtaggccttc taagattaca     3720

actgcctttg tcggccaagg aaagtccttt gttgangcta ctgttccttg tgctcagtga     3780

atgtgttgac tcccacaaat ggctcttggc atttgcagtc ccaagggtgc gcttcgccaa     3840

tgacgaccgg caccgcctgg cctgctgctc cctggacggc agcatctccc tgtgccagct     3900

ggtgcctgcc ccacccactg tgctccatgt gctacggggc catacacgtg gcgtctcgga     3960

cttcgcctgg tccctctcca atgacatcct tgtgtccacc tccctcgatg ccaccatgcg     4020

catctgggcc tccgaggacg gccgctgcat ccgtgagatc cctgaccctg atggcgccga     4080

attgctctgc tgcaccttcc agccagtcaa caacaacctc actgtggtca ggctccagga     4140

cactgctcac caagggcggg catgctgggt ctggagggct gtcctggggc actagagaat     4200

aaggcttaat acccccaagt cctatcccag ccgtcctgtg gtcagactca aagggaaaga     4260

gaccaacgaa aagcacagtt tgtggtctgg aatggccttg ctgtgtagac ttgtgtgtag     4320

actcccgagc tgggatggag gggttgtctc ctagccctgg gattccactg gtcccatcca     4380

ccacagtctc acagttttct gtctacaggg gctgctgcta tggggcagga tgatgaggct     4440

gaaagctcat ctagtctgtc agtggcagcc ccactgttgt cagactccag gacagactgg     4500

ccagagggca gaggaaggac atggaaagtc tggcatgacc tggggggtag ggagttgaaa     4560

tataggggaa caacaggcca tgagtgagct agcgcttggg gctctgtctc tttgtaatgg     4620

tagcagctca tgggcttcag gaggggacag tccagggtat aagggaaaga tgtaaaggtg     4680

tcacaaggcg aggttttcag actcagagac taagactgct ttggtctcgt gagaccaact     4740

attgtgggca ttttgagggc acagctaagg agtaggaatt gtgcctgggt caccttctgg     4800

tatacctggc ctggtcccac tgtgttaaac acaaaggact agatggctca gaatgatggt     4860

gtatgcctgt cacccacagg tggggaacgc caagcacaac gtgcatgtca tgaacatctc     4920

cacaggcaag aaagtgaagg gtggctccag caagctcacc ggccgcgtcc tcgccctgtc     4980

ctttgatgcc cctggtcggc tgctctgggc aggcgatgac cgcggcagtg tcttctcctt     5040

tctctttgac atggccacag gtaggcagac cacagacttc gggttcggta cccctggttt     5100

tcattctccc aggactcagt ccttgtcctc cactgattca ggaaagctga ccaaagccaa     5160

gcgactagta gtgcatgaag gcagccctgt aaccagcatt tctgcccggt cctgggtcag     5220

ccgtgaagca cgggacccct ctctgctcat caatgcctgc ctcaacaagc tgctactcta     5280

caggtgggtt cctcccccag agtggaacaa gaacctgtct ctgtcacatt aatttcacca     5340

aggacagagg acctcataat atgatgagga tagggtcgga gatgtaactt agtggcagag     5400

tgctgatcta gctggtacag agctgtgtgt tccatcccca gaaacacgcc acatacacac     5460

acacagtata tatctatatc tatgtctatg tctatatatt tgtgtgtgta tatatatata     5520

cacatatata tacatacata tatatatata tatatttata tagtgattcc ttacctacta     5580

tatatatata tactatgcaa taatggtgat atcaatagca acataaatag gaatagcagt     5640

aataagactc tacatgaaca ttgctatggc taggtcccat tcaaagcact ttgtatatat     5700

caccttattt aatcttcaca atcagtggta gagcactcgc ctagcatgta taaggctgtg     5760

ggttccactc tcaacattat aactaaagaa aaaaccacca gcacctattc ctctttcctt     5820

gttttgaatt tttcacgtgt gtgtgtgtgt gtgtgtgtat gcttgcatac catggagcat     5880

atacggaggg aggtcagagg acaacttgtg gcagtctgtt ctgttcttca tgtaggttct     5940

aggaatggaa gtcaaggaat tggcagccaa ggttctagga attggcagcc tggcagcgtg     6000

tgtctttatc cacttgagtc atctctacag ttccctttct ttatttttgt ttcttttgtc     6060

tgggaattga acccagaacc ttgcacatgc tagtaacaca cgtcaccact gagatatacc     6120

cacagcctat attattgtgt tgatttgatt tggggacaga attcactctt cccactcgct     6180

tctgtcacgg tacgattctt cagctggggt gtataaaatg ataggcagag ctccttttgg     6240

aaggtgtgct gctcgcactg ggcataataa gctcatgtac agtacttgag aggcggaagc     6300

aggttgatct atgtgaattc aagatgagcc tgacctacct acatagcaag tttcaggtta     6360

gcctgaacta cacagcaaga ccctgtccta aaataaacaa gcaaacaaaa cctaaggggc     6420

tggagagatg gctcagcagc agttaagaac acttgttgct ctttcagacg actgaggttc     6480

agttcccagc agtcatgcca gcttacacct gtctgtaatt ccagctccag gaatctaacc     6540

cctcttctgg cctcttctag tactatacac acgtggtgaa cagacgcaat gctggtaaaa     6600

cagccataca cataaagtga aaatacataa gtataaagaa aagttagcgt gatgatacac     6660

acctatgatg ccagcactca aaggcctgat gcaggaggat cattgagtgc aggagctcag     6720

actcaacttg gacaacaaaa taaggctctg tctccaaagg aaaaggaaaa tcgaaattgt     6780

ttgtacattg taaatatctg agatgcagga ttcagagcgt atactggccc ataactcgtc     6840

gtctcctgag gctgaggctg tgccctgacc ttctcttttg ctttctcttc agagtggtgg     6900

acaacgaagg ggcgctacag ctgaagagaa gctt                                 6934


<210>  3A
<211>  6875
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  pCMV-FLAG-Wdr13 from position 922 to 2443 -  for overexpression        
of FLAG tagged WDR13 protein

<400>  3A
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccatggacta caaggacgac gatgacaagg aattccggat      960

ggccgcggtg tggcagcaag tattagcagt ggacgcgagg tacaacgcct accgtacacc     1020

aacgtttcca cagtttcgga cccagtatat ccgccggcgc agccagctgc ttcgggagaa     1080

tgccaaagct ggtcaccccc cagcattgcg tcggcagtac ctgaggctac ggggccagct     1140

attgggccaa cggtacgggc cactctcaga accaggcagt gctcgtgcct atagcaacag     1200

cattgtccgc agcagccgaa caacccttga tcgaatggag gactttgaag atgaccccag     1260

agccctgggg gctcgaggac accgccgatc tgtcagccga ggttcctacc agctgcaggc     1320

acaaatgaac cgtgcagtct atgaggacag gcctcctggc agtgtggtac ccacgtcggt     1380

ggcagaggca agtcgggcca tggccgggga cacgtcgctg agtgagaact atgcctttgc     1440

aggcatgtac catgtttttg accaacacgt ggatgaggca gtcccaaggg tgcgcttcgc     1500

caatgacgac cggcaccgcc tggcctgctg ctccctggac ggcagcatct ccctgtgcca     1560

gctggtgcct gccccaccca ctgtgctcca tgtgctacgg ggccatacac gtggcgtctc     1620

ggacttcgcc tggtccctct ccaatgacat ccttgtgtcc acctccctcg atgccaccat     1680

gcgcatctgg gcctccgagg acggccgctg catccgtgag atccctgacc ctgatggcgc     1740

cgaattgctc tgctgcacct tccagccagt caacaacaac ctcactgtgg tggggaacgc     1800

caagcacaac gtgcatgtca tgaacatctc cacaggcaag aaagtgaagg gtggctccag     1860

caagctcacc ggccgcgtcc tcgccctgtc ctttgatgcc cctggtcggc tgctctgggc     1920

aggcgatgac cgcggcagtg tcttctcctt tctctttgac atggccacag gaaagctgac     1980

caaagccaag cgactagtag tgcatgaagg cagccctgta accagcattt ctgcccggtc     2040

ctgggtcagc cgtgaagcac gggacccctc tctgctcatc aatgcctgcc tcaacaagct     2100

gctactctac agagtggtgg acaacgaagg ggcgctacag ctgaagagaa gcttccccat     2160

tgaacagagt tcccaccctg tacgcagtat cttctgcccc ctcatgtcct tccgccaggg     2220

ggcctgtgtg gtgacaggca gtgaagatat gtgcgttcac ttctttgacg tggagcgggc     2280

agccaaggct gctgttaaca agctgcaggg ccacagcgcg cccgtgcttg acgtcagctt     2340

caactgtgac gagagtctgc tggcctccag tgatgccagt ggcatggtca tcgtctggag     2400

acgagagcaa aagtagggtt ctgtcaccct gtgctgctct agagggcccg tttaaacccg     2460

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     2520

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     2580

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     2640

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc     2700

ttctgaggcg gaaagaacca gctggggctc tagggggtat ccccacgcgc cctgtagcgg     2760

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     2820

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     2880

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     2940

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     3000

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     3060

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     3120

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg     3180

tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg cagaagtatg     3240

caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg ctccccagca     3300

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact     3360

ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     3420

atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt ccagaagtag     3480

tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tcccgggagc ttgtatatcc     3540

attttcggat ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga     3600

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     3660

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     3720

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg     3780

ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     3840

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     3900

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     3960

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     4020

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     4080

ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg     4140

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     4200

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     4260

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     4320

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg     4380

ggactctggg gttcgaaatg accgaccaag cgacgcccaa cctgccatca cgagatttcg     4440

attccaccgc cgccttctat gaaaggttgg gcttcggaat cgttttccgg gacgccggct     4500

ggatgatcct ccagcgcggg gatctcatgc tggagttctt cgcccacccc aacttgttta     4560

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat     4620

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     4680

gtataccgtc gacctctagc tagagcttgg cgtaatcatg gtcatagctg tttcctgtgt     4740

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     4800

cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     4860

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     4920

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4980

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     5040

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     5100

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     5160

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     5220

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     5280

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     5340

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     5400

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     5460

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     5520

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     5580

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5640

aaaccaccgc tggtagcggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     5700

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     5760

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     5820

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     5880

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     5940

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     6000

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     6060

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     6120

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     6180

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     6240

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     6300

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     6360

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     6420

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     6480

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     6540

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     6600

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     6660

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     6720

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     6780

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     6840

cgcgcacatt tccccgaaaa gtgccacctg acgtc                                6875


<210>  3B
<211>  6906
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  pCMV-Myc-Wdr13 FROM POSITION 900 - 2448- for overexpression of 
       Myc tagged WDR13 protein

<400>  3B
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

atggaggagc agaagctgat ctcagaggag gacctgcata tggccatgga ggccgaattc      960

cggatggccg cggtgtggca gcaagtatta gcagtggacg cgaggtacaa cgcctaccgt     1020

acaccaacgt ttccacagtt tcggacccag tatatccgcc ggcgcagcca gctgcttcgg     1080

gagaatgcca aagctggtca ccccccagca ttgcgtcggc agtacctgag gctacggggc     1140

cagctattgg gccaacggta cgggccactc tcagaaccag gcagtgctcg tgcctatagc     1200

aacagcattg tccgcagcag ccgaacaacc cttgatcgaa tggaggactt tgaagatgac     1260

cccagagccc tgggggctcg aggacaccgc cgatctgtca gccgaggttc ctaccagctg     1320

caggcacaaa tgaaccgtgc agtctatgag gacaggcctc ctggcagtgt ggtacccacg     1380

tcggtggcag aggcaagtcg ggccatggcc ggggacacgt cgctgagtga gaactatgcc     1440

tttgcaggca tgtaccatgt ttttgaccaa cacgtggatg aggcagtccc aagggtgcgc     1500

ttcgccaatg acgaccggca ccgcctggcc tgctgctccc tggacggcag catctccctg     1560

tgccagctgg tgcctgcccc acccactgtg ctccatgtgc tacggggcca tacacgtggc     1620

gtctcggact tcgcctggtc cctctccaat gacatccttg tgtccacctc cctcgatgcc     1680

accatgcgca tctgggcctc cgaggacggc cgctgcatcc gtgagatccc tgaccctgat     1740

ggcgccgaat tgctctgctg caccttccag ccagtcaaca acaacctcac tgtggtgggg     1800

aacgccaagc acaacgtgca tgtcatgaac atctccacag gcaagaaagt gaagggtggc     1860

tccagcaagc tcaccggccg cgtcctcgcc ctgtcctttg atgcccctgg tcggctgctc     1920

tgggcaggcg atgaccgcgg cagtgtcttc tcctttctct ttgacatggc cacaggaaag     1980

ctgaccaaag ccaagcgact agtagtgcat gaaggcagcc ctgtaaccag catttctgcc     2040

cggtcctggg tcagccgtga agcacgggac ccctctctgc tcatcaatgc ctgcctcaac     2100

aagctgctac tctacagagt ggtggacaac gaaggggcgc tacagctgaa gagaagcttc     2160

cccattgaac agagttccca ccctgtacgc agtatcttct gccccctcat gtccttccgc     2220

cagggggcct gtgtggtgac aggcagtgaa gatatgtgcg ttcacttctt tgacgtggag     2280

cgggcagcca aggctgctgt taacaagctg cagggccaca gcgcgcccgt gcttgacgtc     2340

agcttcaact gtgacgagag tctgctggcc tccagtgatg ccagtggcat ggtcatcgtc     2400

tggagacgag agcaaaagta gggttctgtc accctgtgct gctctagagg gccctattct     2460

atagtgtcac ctaaatgcta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     2520

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     2580

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     2640

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     2700

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctctag     2760

ggggtatccc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     2820

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     2880

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcggggca tccctttagg     2940

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     3000

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     3060

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     3120

ttttgattta taagggattt tggggatttc ggcctattgg ttaaaaaatg agctgattta     3180

acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc     3240

ccaggctccc caggcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccag     3300

gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta     3360

gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc     3420

cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc     3480

ctctgcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg     3540

caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga caggatgagg     3600

atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga     3660

gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt     3720

ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct     3780

gaatgaactg caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg     3840

cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt     3900

gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc     3960

tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc     4020

gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga     4080

tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg     4140

catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat     4200

ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg     4260

ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc     4320

tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta     4380

tcgccttctt gacgagttct tctgagcggg actctggggt tcgaaatgac cgaccaagcg     4440

acgcccaacc tgccatcacg agatttcgat tccaccgccg ccttctatga aaggttgggc     4500

ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg     4560

gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat     4620

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     4680

aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg     4740

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     4800

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     4860

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     4920

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     4980

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     5040

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     5100

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     5160

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     5220

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     5280

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     5340

tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     5400

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     5460

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     5520

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     5580

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     5640

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     5700

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     5760

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     5820

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     5880

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     5940

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     6000

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     6060

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     6120

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     6180

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     6240

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     6300

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     6360

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     6420

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     6480

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     6540

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     6600

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     6660

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     6720

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     6780

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     6840

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     6900

gacgtc                                                                6906


<210>  4
<211>  10967
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  pCMV-Myc-PHIP1 from position 900 - 6509 for overexpression of Myc
       tagged PHIP1 protein

<400>  4
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

atggaggagc agaagctgat ctcagaggag gacctgcata tggccatgga ggccgaattc      960

ctctcggagc tgcgatcgga gctctacttc ctcatcgccc ggttcctgga agatggaccc     1020

tgtcagcagg cggctcaggt gctgatccgc gaagtggccg agaaggagct gctgccccgg     1080

cgcaccgact ggaccgggaa ggagcacccc aggacctacc agaatctggt gaagtattat     1140

agacaccttg cacctgatca cttgctgcaa atatgtcatc ggctaggacc tcttcttgag     1200

caagaaattc ctcagagtgt tcctggagta cagactttac taggagctgg aagacagtcc     1260

ttgctacgaa caaataaaag ctgcaagcat gtggtatgga aaggatctgc cctggctgca     1320

ctgcactgtg ggaggccgcc agagtctcca gttaactacg gtagcccacc tagcattgcg     1380

gatactctgt tttcaaggaa gctgaatggg aaatacagac ttgaacgact tgttccaact     1440

gcagtttatc agcacatgaa gatgcataag cgaattcttg gacacttatc atcggtgtac     1500

tgtgtaactt ttgatcgaac tggcaggcgg atatttactg gttctgatga ttgtcttgtg     1560

aaaatctggg ccacagacga tggaagattg ctagctactt taagaggaca tgctgctgaa     1620

atatcagaca tggctgtaaa ctatgagaat actatgatag cagctggaag ttgtgataaa     1680

atgattcgtg tctggtgtct tcgaacctgt gcacctttgg ctgttcttca gggacatagt     1740

gcatctatta catcactaca gttctcacca ttgtgcagtg gctcaaagag atacctgtct     1800

tctacagggg cggacggcac tatttgcttt tggctttggg atgctggaac ccttaaaata     1860

aatccaagac ccacaaaatt tacagagcgt cctcggcctg gagtgcaaat gatatgttct     1920

tcgttcagtg ctggtgggat gtttttggcc actggaagca ctgaccatat tattagagtt     1980

tatttttttg gatcaggtca gccagaaaaa atatcagaat tggagtttca tactgacaaa     2040

gttgacagta tccagttttc caacactagt aacaggtttg tgagtggtag tcgtgatggg     2100

acagcacgaa tttggcagtt taaacgaagg gaatggaaaa gcattttgtt agatatggct     2160

actcgtccag caggccaaaa tcttcaaggc atagaagaca aaatcacaaa aatgaaagta     2220

actatggtag cttgggatcg acatgacaac acagttataa ctgcagttaa taacatgact     2280

ctgaaagttt ggaattctta tactggtcaa ctgatacatg ttctaatggg tcatgaagat     2340

gaggtgtttg ttcttgagcc acacccattt gatcctagag ttctcttctc tgctggtcat     2400

gatggaaatg tgatagtgtg ggatctagca agaggagtca aagttcgatc ttatttcaat     2460

atgattgaag gacaaggaca tggtgcagtg tttgactgca aatgctcccc tgatggtcag     2520

cactttgcat gtacagactc tcatggacat cttttaattt ttggttttgg gtccagtagc     2580

aagtatgaca agatagcaga tcagatgttt tttcacagtg attatcggcc tcttatccgt     2640

gatgcgaaca attttgtatt agatgagcag acgcagcagg cacctcacct catgcctccc     2700

ccttttctgg ttgatgttga tggaaatcct catccatcaa ggtaccagcg attggttcct     2760

ggtcgggaga actgcaggga ggagcagctc attcctcaga tgggagtaac ttcttcagga     2820

ttgaaccaag ttttgagcca gcaagcaaac caggatatta gtcctttaga cagcatgatt     2880

caaagactgc agcaggagca ggacctgagg cgttcgggtg aagcaggtgt tagtaatgcc     2940

agccgtgtga acagaggctc agtaagttct acctccgaag ttcattcacc accaaatata     3000

ggattaaggc gcagtggcca aatcgaaggt gtacggcaga tgcacagcaa tgctccgaga     3060

agtgaaatag ccacagagcg agatcttgtt gcttggagtc ggagggtagt agtgcctgag     3120

ctctcggctg gtgtggctag tagacaagaa gaatggagaa ctgcaaaggg agaagaggaa     3180

ataaagagtt atagatcaga agagaaaagg aaacacttaa ctgttgcaaa agagaataaa     3240

atacttactg tctcaaagaa tcatgctcat gagcatttcc tggatcttgg ggattctaaa     3300

aagcagcaag cgaatcagca caattaccgt acaagatctg cactggaaga aacacccagg     3360

cccttagagg agctagaaaa cggaactagt tcttcagatg aaggtgaagt acttgctgtc     3420

agtggtggga cttctgagga agaggagcga gcatggcaca gtgatggcag ctccagtgac     3480

tactccagtg attattctga ttggacagca gatgctggaa ttaacttgca gccaccaaag     3540

aaagttccta agcataaaac caagaaacca gaaagtagtt cagatgaaga agaagaatct     3600

gaaaaccaga agcaaaaaca tattaaaaag gaaagaaaaa aagcaaatga agaaaaagat     3660

ggaccaacat caccaaagaa aaaaaagccc aaagaaagaa aacaaaagag attggctgta     3720

ggagaactaa ctgagaatgg cctaacgtta gaagagtggt tgccttcagc ttggattaca     3780

gacacacttc ccaggagatg tccatttgtg ccacagatgg gtgatgaggt ttattatttt     3840

cgacaagggc atgaagcata tgttgaaatg gcccggaaaa ataaaattta tagtatcaat     3900

cctaaaaagc agccatggca taagatggaa ctaagggaac aagaactaat gaaaattgtt     3960

ggtataaagt atgaagtggg gttgcctacc ctttgctgcc ttaaacttgc ttttctagat     4020

cctgatactg gcaaactgac cggtggatca tttaccatga aataccatga tatgcctgac     4080

gtcatagatt ttctagtctt gagacaacaa tttgatgatg caaagtatag acgatggaat     4140

ataggtgacc gcttcagatc tgtcatagat gatgcctggt ggtttggaac aattgaaagt     4200

caagagcctc ttcaacctga gtaccctgat agtttgtttc agtgttataa tgtatgttgg     4260

gacaatggag atacagaaaa gatgagtcct tgggatatgg aattaatacc taataatgct     4320

gtctttccag aagaactggg taccagtgtt cctttaactg atgttgaatg taggtcgcta     4380

atttataaac ctcttgatgg agaatgggga gccaatccca gggatgaaga atgtgaaaga     4440

attgttggag gaataaatca gctgatgaca ctagatattg cgtctgcatt tgttgcccct     4500

gtggaccttc aagcttatcc catgtattgc actgtggtgg cctatccaac ggatctaagt     4560

acaattaaac aaagactgga gaacaggttt tacaggcgct tttcatcact aatgtgggaa     4620

gttcgatata tagaacataa tacacgaaca ttcaatgagc caggaagccc aattgtgaaa     4680

tctgctaaat ttgtgactga tcttctcctg cattttataa aggatcagac ttgttataac     4740

ataattccac tttacaactc aatgaagaag aaagttttgt ctgactctga ggaagaagag     4800

aaagatgctg atgttccagg gacttctacc agaaagcgca aggatcatca acctagaaga     4860

aggttacgca acagagctca gtcttacgat attcaggcat ggaagaaaca atgtcaagaa     4920

ttactgaatc tcatatttca atgtgaagac tcagaacctt ttcgacagcc agtggatctt     4980

cttgaatatc cagactacag agacatcatt gacactccaa tggactttgc cactgttaga     5040

gagactttag aggctgggaa ttatgagtca cccatggagt tatgtaaaga tgtcaggctc     5100

attttcagta attctaaagc atacacacca agcaagagat caaggattta cagcatgagt     5160

ttacgcctgt ctgctttctt tgaagaacat attagttcag ttttgtcaga ttataaatct     5220

gctcttcgtt ttcataaaag aaacaccata agcaagaaga ggaagaagcg aaacaggagc     5280

agttccctgt ccagcagtgc tgcctcaagc cctgaaagga aaaaaaggat cttaaaaccc     5340

cagctaaagt cagaagtatc tacctctcca ttctccatac ctacaagatc agtactacca     5400

agacataatg ctgcgcaaat gaatggtaaa ccagaatcca gttctgtggt tcgaactagg     5460

agcaaccgtg tagctgtaga tccagttgtc accgagcagc cctctacatc atcagccaca     5520

aaagcttttg tttcaaaaac taatacatct gccatgccag gaaaagcaat gctagagaat     5580

tctgtgagac attccaaagc cttgagcaca ctttccagcc ctgatccgct cacattcagc     5640

catgctacaa agaataattc tgcaaaagaa aacatggaaa aggaaaagcc tgtcaaacgt     5700

aaaatgaagt cttctgtgtt ttcaaaagca tctccacttc caaagtcagc cgcagtcata     5760

gagcaaggag agtgtaagaa caatgttctt ataccaggaa ccattcaagt aaatggccat     5820

ggaggacaac catcaaaact cgtgaagaga ggacctggga ggaagcccaa ggtagaagtt     5880

aacaccagca gtggtgaagt gacacacaag aaaagaggta gaaagcccaa gaatctgcag     5940

tgtgcaaagc aggaaaactc tgagcaaaat aacatgcatc ccatcagggc tgacgtgctt     6000

ccttcttcaa catgcaactt cctttctgaa actaatgctg tcaaggagga tttgttacag     6060

aaaaagagtc gtggaggcag aaaacccaaa aggaagatga aaactcacaa cctagattca     6120

gaactcatag ttcctacaaa tgttaaagtg ttaaggagaa gtaaccggaa aaaaacagat     6180

gatcctatag atgaggaaga ggagtttgaa gaactcaaag gctctgagcc tcacatgaga     6240

actagaaatc agggtcgaag gacagctttc tataatgagg atgactcgga ggaagaacag     6300

agacagctgt tgttcgagga cacctccttg acatttggaa cttctagtag aggacgagtc     6360

cgaaagttga ctgaaaaagc aaaggctaat ttaattggtt ggtaacttga agcaaaatat     6420

tgcattttaa aaaatctgta acgcaggtac agttaaggag taagtagaac taaggtctct     6480

gcttccttgc tgctatgacg gattctagag ggccctattc tatagtgtca cctaaatgct     6540

agagctcgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     6600

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     6660

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     6720

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     6780

tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc ccacgcgccc     6840

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     6900

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     6960

ggctttcccc gtcaagctct aaatcggggc atccctttag ggttccgatt tagtgcttta     7020

cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc     7080

tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg     7140

ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt     7200

ttggggattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat     7260

taattctgtg gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc ccaggcaggc     7320

agaagtatgc aaagcatgca tctcaattag tcagcaacca ggtgtggaaa gtccccaggc     7380

tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg     7440

cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat     7500

ggctgactaa ttttttttat ttatgcagag gccgaggccg cctctgcctc tgagctattc     7560

cagaagtagt gaggaggctt ttttggaggc ctaggctttt gcaaaaagct cccgggagct     7620

tgtatatcca ttttcggatc tgatcaagag acaggatgag gatcgtttcg catgattgaa     7680

caagatggat tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac     7740

tgggcacaac agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg     7800

cgcccggttc tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaggacgag     7860

gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt     7920

gtcactgaag cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg     7980

tcatctcacc ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg     8040

catacgcttg atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga     8100

gcacgtactc ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag     8160

gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc gcatgcccga cggcgaggat     8220

ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt     8280

tctggattca tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg     8340

gctacccgtg atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt     8400

tacggtatcg ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc     8460

ttctgagcgg gactctgggg ttcgaaatga ccgaccaagc gacgcccaac ctgccatcac     8520

gagatttcga ttccaccgcc gccttctatg aaaggttggg cttcggaatc gttttccggg     8580

acgccggctg gatgatcctc cagcgcgggg atctcatgct ggagttcttc gcccacccca     8640

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     8700

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     8760

atcatgtctg tataccgtcg acctctagct agagcttggc gtaatcatgg tcatagctgt     8820

ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa     8880

agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac     8940

tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg     9000

cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc     9060

gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat     9120

ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca     9180

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     9240

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     9300

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     9360

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta     9420

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     9480

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     9540

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     9600

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat     9660

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     9720

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     9780

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     9840

ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct     9900

agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt     9960

ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc    10020

gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac    10080

catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat    10140

cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg    10200

cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata    10260

gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta    10320

tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt    10380

gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag    10440

tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa    10500

gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc    10560

gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt    10620

taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc    10680

tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta    10740

ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa    10800

taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca    10860

tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac    10920

aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtc                  10967


<210>  5
<211>  7131
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  pCMV-Myc-ER from position 900 - 2673 - for overexpression of Myc 
       tagged ER  protein

<400>  5
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc      900

atggaggagc agaagctgat ctcagaggag gacctgcata tggccatgga ggccgaattc      960

cggatgtcca tctgtgcctc ttctcacaag gatttttctc agctgagacc tacgcaagac     1020

atggagatca aaaactcacc atcaagcctt acttcccctg cttcttataa ctgtagccag     1080

tccatcctac ccttggagca tggtcccatc tatatccctt cctcctatgt agagagccgt     1140

cacgaatact cagccatgac attctacagt cctgctgtga tgaactacag tgttcccagc     1200

agcaccggta acctggaagg tgggcctgtt cgccagactg caagcccaaa tgtgctatgg     1260

ccaacttctg gacacctctc tcctttagcc acccactgcc aatcatcgct tctctatgca     1320

gaacctcaaa agagtccttg gtgtgaagca agatcactag aacacacctt gcctgtaaac     1380

agagagaccc tgaagaggaa gcttggcggg agcggttgtg ccagccctgt tactagtcca     1440

agcgccaaga gggatgctca cttctgcgcc gtctgcagtg attatgcatc tgggtatcat     1500

tacggtgtct ggtcctgtga aggatgtaag gcctttttta aaagaagcat tcaaggacat     1560

aatgactata tctgtccagc cacgaatcag tgtaccatag acaagaaccg gcgtaaaagc     1620

tgccaggcct gccgacttcg caagtgttac gaagtaggaa tggtcaagtg tggatccagg     1680

agagaaaggt gtgggtaccg aatagtacga agacagagaa gtgccagcga gcaggtgcat     1740

tgcctgaaca aagccaagag aaccagtggg cacacacccc gggtgaagga gctactgctg     1800

aactctctga gtcccgagca gctggtgctc accctgctgg aagctgagcc acccaatgtg     1860

ctagtgagcc gtcccagcat gcccttcacc gaggcctcca tgatgatgtc cctcacgaag     1920

ctggctgaca aggaactggt gcacatgatt ggctgggcca agaaaatccc tggctttgtg     1980

gagctcagcc tgttggacca agtccgcctc ttggaaagct gctggatgga ggtgctgatg     2040

gtggggctga tgtggcgctc catcgaccac cccggcaagc tcatctttgc tccagacctc     2100

gttctggaca ggtcctcaga agaccctcac tggcacgttg cgcagacgaa gagtgctgtc     2160

ccaagggatg aggggaagtg cgtggaaggg attctggaaa tctttgacat gctcctggcg     2220

acgacggcac ggttccgtga gttaaaactg cagcacaaag aatatctgtg tgtgaaggcc     2280

atgattctcc tcaactccag tatgtacccc ttggctaccg caagccagga agcagagagt     2340

agccggaagc tgacacacct attgaacgca gtgacagatg ccctggtctg ggtgatttcg     2400

aagagtggaa tctcttccca gcagcagtca gtccgtctgg ccaacctcct gatgcttctt     2460

tctcatgtca ggcacatcag taacaagggc atggaacatc tgctcagcat gaagtgcaaa     2520

aatgtggtcc cggtgtacga cctgctgctg gagatgctga atgctcacac gcttcgaggg     2580

tacaagtcct caatctcggg gtctgagtgc tgctcgacag aggacagtaa gagcaaagag     2640

ggctcccaga acctccagtc acagtgatct agagggccct attctatagt gtcacctaaa     2700

tgctagagct cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     2760

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2820

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2880

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2940

gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt atccccacgc     3000

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     3060

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     3120

cgccggcttt ccccgtcaag ctctaaatcg gggcatccct ttagggttcc gatttagtgc     3180

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc     3240

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     3300

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg     3360

gattttgggg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc     3420

gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccaggc     3480

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc     3540

aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt     3600

cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc     3660

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct     3720

attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg     3780

agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt ttcgcatgat     3840

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     3900

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     3960

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga     4020

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     4080

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     4140

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     4200

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     4260

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     4320

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga     4380

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg     4440

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc     4500

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt     4560

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga     4620

gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc caacctgcca     4680

tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc     4740

cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac     4800

cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     4860

acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta     4920

tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag     4980

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     5040

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     5100

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     5160

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     5220

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     5280

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     5340

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     5400

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     5460

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     5520

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc     5580

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     5640

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     5700

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     5760

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     5820

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     5880

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     5940

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     6000

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     6060

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     6120

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     6180

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     6240

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     6300

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     6360

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     6420

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     6480

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     6540

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     6600

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     6660

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     6720

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     6780

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     6840

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     6900

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     6960

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     7020

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     7080

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt c              7131


<210>  6
<211>  6628
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  pCMV-FLAG-NR2E1 from position 922 - 2196- for overexpression of 
       FLAG tagged NR2E1 protein

<400>  6
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccatggacta caaggacgac gatgacaagg aattccggat      960

gagcaagccc gccggatcaa caagccgcat tttagatatc ccttgcaaag tgtgtggtga     1020

ccgcagctcc gggaagcact acggggtcta cgcttgcgac ggctgctccg gattcttcaa     1080

gaggagcatt cgaaggaata ggacctatgt ctgcaagtct ggaaaccagg gaggatgccc     1140

cgtagacaag acacacagaa accaatgcag ggcgtgtcga ctgaagaagt gtttggaagt     1200

caacatgaac aaagatgccg tgcagcacga gcggggtcct cggacgtcca ccatccgcaa     1260

acaggtggct ctctacttcc gtggacacaa ggaagacaat ggggccgctg cgcacttccc     1320

ctccacggcg ctgccagccc ctgctttctt cacagcggtc acgcagctgg agccgcacgg     1380

tctggagttg gccgctgtgt ctgccactcc tgaacggcag actctcgtga gcctggctca     1440

gcccacgccc aagtatcccc atgaagtgaa tgggacccca atgtatctct acgaagtggc     1500

cactgagtcc gtgtgtgaat cagctgccag gcttctcttt atgagcatca agtgggcaaa     1560

gagtgtgcca gccttttcca ctttgtcttt acaagatcag ctgatgcttt tggaagacgc     1620

gtggagagaa ctgtttgttc taggaatagc acaatgggcc attccggttg atgctaacac     1680

tctactggct gtatctggca tgaatactga caacacagac tcccagaagc tgaacaagat     1740

catatctgaa atacaggctt tgcaagaggt ggtggctcgg ttcagacagc tccgattaga     1800

cgccactgaa tttgcctgtc tgaaatgtat tgtcactttc aaagctgttc ctacacacag     1860

tggttctgaa ctgagaagtt tccggaatgc tgccgccatt gccgctctcc aagatgaggc     1920

tcagctaact ctcaacagct acattcatac cagatacccc acccaaccct gccgattcgg     1980

gaaactcctg ttgcttttac cagctttacg gtcaattagc ccatctacca tagaagaagt     2040

gtttttcaaa aaaaccatcg gcaatgtgcc gattacaaga ctactttcag atatgtacaa     2100

atccagtgac atctaagggc tccagtaccc acttttccaa gatggggcag tattagatgg     2160

acatctacat gcaggtcaag cctcaaaagc tctagagggc ccgtttaaac ccgctgatca     2220

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     2280

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     2340

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     2400

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     2460

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     2520

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2580

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2640

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2700

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2760

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2820

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     2880

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2940

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     3000

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     3060

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     3120

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     3180

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     3240

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     3300

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     3360

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     3420

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     3480

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     3540

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     3600

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     3660

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     3720

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     3780

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     3840

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     3900

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     3960

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     4020

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     4080

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     4140

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     4200

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     4260

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     4320

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     4380

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     4440

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     4500

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     4560

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     4620

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     4680

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     4740

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     4800

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     4860

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     4920

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     4980

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     5040

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     5100

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     5160

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     5220

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     5280

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     5340

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     5400

cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     5460

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     5520

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     5580

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     5640

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     5700

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     5760

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     5820

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     5880

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     5940

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     6000

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     6060

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     6120

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     6180

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     6240

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     6300

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     6360

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     6420

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     6480

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     6540

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     6600

atttccccga aaagtgccac ctgacgtc                                        6628


<210>  7
<211>  4921
<212>  DNA
<213>  ARTIFICIAL SEQ

<220>
<223>  ERE-TATA-LUC from position 28 - 144 - to measure estrogen 
       receptor mediated activity

<400>  7
ggtaccgagc tcttacgcgt gctagcccga gcttaggtca ctgtgacctg agcttaggtc       60

actgtgacct gagcttaggt cactgtgacc tgcatgcctg caggtatacg tcgactctag      120

agggtatata atggatccag atctgcgatc taagtaagct tggcattccg gtactgttgg      180

taaagccacc atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct      240

ggaagatgga accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc      300

tggaacaatt gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt      360

cgaaatgtcc gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag      420

aatcgtcgta tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt      480

tatcggagtt gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag      540

tatgggcatt tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt      600

gaacgtgcaa aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga      660

ttaccaggga tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa      720

tgaatacgat tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa      780

ctcctctgga tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt      840

gagattctcg catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat      900

tttaagtgtt gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat      960

atgtggattt cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct     1020

tcaggattac aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa     1080

aagcactctg attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc     1140

tcccctctct aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag     1200

gcaaggatat gggctcactg agactacatc agctattctg attacacccg agggggatga     1260

taaaccgggc gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga     1320

taccgggaaa acgctgggcg ttaatcaaag aggcgaactg tgtgtgagag gtcctatgat     1380

tatgtccggt tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg     1440

gctacattct ggagacatag cttactggga cgaagacgaa cacttcttca tcgttgaccg     1500

cctgaagtct ctgattaagt acaaaggcta tcaggtggct cccgctgaat tggaatccat     1560

cttgctccaa caccccaaca tcttcgacgc aggtgtcgca ggtcttcccg acgatgacgc     1620

cggtgaactt cccgccgccg ttgttgtttt ggagcacgga aagacgatga cggaaaaaga     1680

gatcgtggat tacgtcgcca gtcaagtaac aaccgcgaaa aagttgcgcg gaggagttgt     1740

gtttgtggac gaagtaccga aaggtcttac cggaaaactc gacgcaagaa aaatcagaga     1800

gatcctcata aaggccaaga agggcggaaa gatcgccgtg taattctaga gtcggggcgg     1860

ccggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag     1920

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     1980

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     2040

tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat     2100

cgataaggat ccgtcgaccg atgcccttga gagccttcaa cccagtcagc tccttccggt     2160

gggcgcgggg catgactatc gtcgccgcac ttatgactgt cttctttatc atgcaactcg     2220

taggacaggt gccggcagcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     2280

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     2340

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     2400

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     2460

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     2520

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     2580

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     2640

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     2700

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     2760

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     2820

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     2880

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     2940

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     3000

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     3060

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     3120

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     3180

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     3240

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     3300

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     3360

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     3420

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     3480

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     3540

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     3600

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     3660

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     3720

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     3780

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     3840

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     3900

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     3960

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     4020

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     4080

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     4140

gttccgcgca catttccccg aaaagtgcca cctgacgcgc cctgtagcgg cgcattaagc     4200

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     4260

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     4320

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     4380

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     4440

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     4500

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     4560

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     4620

cttacaattt gccattcgcc attcaggctg cgcaactgtt gggaagggcg atcggtgcgg     4680

gcctcttcgc tattacgcca gcccaagcta ccatgataag taagtaatat taaggtacgg     4740

gaggtacttg gagcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt     4800

ttttgtgtga atcgatagta ctaacatacg ctctccatca aaacaaaacg aaacaaaaca     4860

aactagcaaa ataggctgtc cccagtgcaa gtgcaggtgc cagaacattt ctctatcgat     4920

a                                                                     4921


<210>  8
<211>  20
<212>  DNA
<213>  Forward Primer Wdr13E2

<400>  8
aacgcctacc gtacaccaac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Reverse Primer Wdr13E2

<400>  9
tgctataggc acgagcactg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Forward Primer Neo

<400>  10
gatcggccat tgaacaagat                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Reverse Primer Neo

<400>  11
atactttctc ggcaggagca                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Forward Primer p21CHIP

<400>  12
caggctggtc ttgaacctgt                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Reverse Primer p21CHIP

<400>  13
aggcattcaa ggtcgttttg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Forward Primer CHIP CON

<400>  14
tggaactgct tctggtgaac                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Reverse Primer CHIP CON

<400>  15
atccgcctct ggcattttgg                                                   20


<210>  16
<211>  29
<212>  DNA
<213>  Forward Primer T7

<400>  16
gctctagagc agcacagggt gacagaacc                                         29


<210>  17
<211>  32
<212>  DNA
<213>  Forward Primer 2E1

<400>  17
ccggaattcc ggatgagcaa gcccgccgga tc                                     32


<210>  18
<211>  30
<212>  DNA
<213>  Reverse Primer 2E1

<400>  18
gctctagagc ttttgaggct tgacctgcat                                        30


<210>  19
<211>  20
<212>  DNA
<213>  Forward Primer PHIP for N terminal WD domain

<400>  19
ctcgtgagca cacactgaca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Reverse Primer PHIP for N terminal WD domain

<400>  20
ttccatatcc caaggactca                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Forward Primer PHIP for C terminal bromo domain

<400>  21
cccaggagat gtccatttgt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Reverse Primer PHIP for C terminal bromo domain

<400>  22
aatccgtcat agcagcaagg                                                   20


<210>  23
<211>  31
<212>  DNA
<213>  Forward Primer for ER beta cDNA amplification

<400>  23
gcaggaattc atgtccatct gtgcctcttc t                                      31


<210>  24
<211>  30
<212>  DNA
<213>  Reverse Primer for ER beta cDNA amplification

<400>  24
cagtctagat cactgtgact ggaggttctg                                        30


