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<110>  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
       UNIVERSITE MONTPELLIER 1
       CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  DIAGNOSIS METHOD OF TUBERCULOSIS

<130>  WOB 10 DC MTP LIPY

<150>  EP 11168643.2
<151>  2011-06-03

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  194
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Cys Pro 
1               5                   10                  15      


Asp Ala Glu Val Val Phe Ala Arg Gly Thr Gly Glu Pro Pro Gly Leu 
            20                  25                  30          


Gly Arg Val Gly Gln Ala Phe Val Ser Ser Leu Arg Gln Gln Thr Asn 
        35                  40                  45              


Lys Ser Ile Gly Thr Tyr Gly Val Asn Tyr Pro Ala Asn Gly Asp Phe 
    50                  55                  60                  


Leu Ala Ala Ala Asp Gly Ala Asn Asp Ala Ser Asp His Ile Gln Gln 
65                  70                  75                  80  


Met Ala Ser Ala Cys Arg Ala Thr Arg Leu Val Leu Gly Gly Tyr Ser 
                85                  90                  95      


Gln Gly Ala Ala Val Ile Asp Ile Val Thr Ala Ala Pro Leu Pro Gly 
            100                 105                 110         


Leu Gly Phe Thr Gln Pro Leu Pro Pro Ala Ala Asp Asp His Ile Ala 
        115                 120                 125             


Ala Ile Ala Leu Phe Gly Asn Pro Ser Gly Arg Ala Gly Gly Leu Met 
    130                 135                 140                 


Ser Ala Leu Thr Pro Gln Phe Gly Ser Lys Thr Ile Asn Leu Cys Asn 
145                 150                 155                 160 


Asn Gly Asp Pro Ile Cys Ser Asp Gly Asn Arg Trp Arg Ala His Leu 
                165                 170                 175     


Gly Tyr Val Pro Gly Met Thr Asn Gln Ala Ala Arg Phe Val Ala Ser 
            180                 185                 190         


Arg Ile 
        


<210>  2
<211>  199
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  2

Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Asp Pro 
1               5                   10                  15      


Cys Ser Asp Ile Ala Val Val Phe Ala Arg Gly Thr His Gln Ala Ser 
            20                  25                  30          


Gly Leu Gly Asp Val Gly Glu Ala Phe Val Asp Ser Leu Thr Ser Gln 
        35                  40                  45              


Val Gly Gly Arg Ser Ile Gly Val Tyr Ala Val Asn Tyr Pro Ala Ser 
    50                  55                  60                  


Asp Asp Tyr Arg Ala Ser Ala Ser Asn Gly Ser Asp Asp Ala Ser Ala 
65                  70                  75                  80  


His Ile Gln Arg Thr Val Ala Ser Cys Pro Asn Thr Arg Ile Val Leu 
                85                  90                  95      


Gly Gly Tyr Ser Gln Gly Ala Thr Val Ile Asp Leu Ser Thr Ser Ala 
            100                 105                 110         


Met Pro Pro Ala Val Ala Asp His Val Ala Ala Val Ala Leu Phe Gly 
        115                 120                 125             


Glu Pro Ser Ser Gly Phe Ser Ser Met Leu Trp Gly Gly Gly Ser Leu 
    130                 135                 140                 


Pro Thr Ile Gly Pro Leu Tyr Ser Ser Lys Thr Ile Asn Leu Cys Ala 
145                 150                 155                 160 


Pro Asp Asp Pro Ile Cys Thr Gly Gly Gly Asn Ile Met Ala His Val 
                165                 170                 175     


Ser Tyr Val Gln Ser Gly Met Thr Ser Gln Ala Ala Thr Phe Ala Ala 
            180                 185                 190         


Asn Arg Leu Asp His Ala Gly 
        195                 


<210>  3
<211>  455
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  3

Pro Glu Val Val Phe Ile His Gly Ser Val Val Ser Tyr Val Val Ala 
1               5                   10                  15      


Leu Pro Glu Val Met Ser Ala Ala Ala Thr Asp Val Ala Ser Ile Gly 
            20                  25                  30          


Ser Val Val Ala Thr Ala Ser Gln Gly Val Ala Gly Ala Thr Thr Thr 
        35                  40                  45              


Val Leu Ala Ala Ala Glu Asp Glu Val Ser Ala Ala Ile Ala Ala Leu 
    50                  55                  60                  


Phe Ser Gly His Gly Gln Asp Tyr Gln Ala Leu Ser Ala Gln Leu Ala 
65                  70                  75                  80  


Val Phe His Glu Arg Phe Val Gln Ala Leu Thr Gly Ala Ala Lys Gly 
                85                  90                  95      


Tyr Ala Ala Ala Glu Leu Ala Asn Ala Ser Leu Leu Gln Ser Glu Phe 
            100                 105                 110         


Ala Ser Gly Ile Gly Asn Gly Phe Ala Thr Ile His Gln Glu Ile Gln 
        115                 120                 125             


Arg Ala Pro Thr Ala Leu Ala Ala Gly Phe Thr Gln Val Pro Pro Phe 
    130                 135                 140                 


Ala Ala Ala Gln Ala Gly Ile Phe Thr Gly Thr Pro Ser Gly Ala Ala 
145                 150                 155                 160 


Gly Phe Asp Ile Ala Ser Leu Trp Pro Val Lys Pro Leu Leu Ser Leu 
                165                 170                 175     


Ser Ala Leu Glu Thr His Phe Ala Ile Pro Asn Asn Pro Leu Leu Ala 
            180                 185                 190         


Leu Ile Ala Ser Asp Ile Pro Pro Leu Ser Trp Phe Leu Gly Asn Ser 
        195                 200                 205             


Pro Pro Pro Leu Leu Asn Ser Leu Leu Gly Gln Thr Val Gln Tyr Thr 
    210                 215                 220                 


Thr Tyr Asp Gly Met Ser Val Val Gln Ile Thr Pro Ala His Pro Thr 
225                 230                 235                 240 


Gly Glu Tyr Val Val Ala Ile His Gly Gly Ala Phe Ile Leu Pro Pro 
                245                 250                 255     


Ser Ile Phe His Trp Leu Asn Tyr Ser Val Thr Ala Tyr Gln Thr Gly 
            260                 265                 270         


Ala Thr Val Gln Val Pro Ile Tyr Pro Leu Val Gln Glu Gly Gly Thr 
        275                 280                 285             


Ala Gly Thr Val Val Pro Ala Met Ala Gly Leu Ile Ser Thr Gln Ile 
    290                 295                 300                 


Ala Gln His Gly Val Ser Asn Val Ser Val Val Gly Asp Ser Ala Gly 
305                 310                 315                 320 


Gly Asn Leu Ala Leu Ala Ala Ala Gln Tyr Met Val Ser Gln Gly Asn 
                325                 330                 335     


Pro Val Pro Ser Ser Met Val Leu Leu Ser Pro Trp Leu Asp Val Gly 
            340                 345                 350         


Thr Trp Gln Ile Ser Gln Ala Trp Ala Gly Asn Leu Ala Val Asn Asp 
        355                 360                 365             


Pro Leu Val Ser Pro Leu Tyr Gly Ser Leu Asn Gly Leu Pro Pro Thr 
    370                 375                 380                 


Tyr Val Tyr Ser Gly Ser Leu Asp Pro Leu Ala Gln Gln Ala Val Val 
385                 390                 395                 400 


Leu Glu His Thr Ala Val Val Gln Gly Ala Pro Phe Ser Phe Val Leu 
                405                 410                 415     


Ala Pro Trp Gln Ile His Asp Trp Ile Leu Leu Thr Pro Trp Gly Leu 
            420                 425                 430         


Leu Ser Trp Pro Gln Ile Asn Gln Gln Leu Gly Ile Ala Ala Ser Asp 
        435                 440                 445             


Ile His His His His His His 
    450                 455 


<210>  4
<211>  279
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  4

Gly Thr Thr Thr Arg Thr Glu Arg Asn Phe Ala Gly Ile Gly Asp Val 
1               5                   10                  15      


Arg Ile Val Tyr Asp Val Trp Thr Pro Asp Thr Ala Pro Gln Ala Val 
            20                  25                  30          


Val Val Leu Ala His Gly Leu Gly Glu His Ala Arg Arg Tyr Asp His 
        35                  40                  45              


Val Ala Gln Arg Leu Gly Ala Ala Gly Leu Val Thr Tyr Ala Leu Asp 
    50                  55                  60                  


His Arg Gly His Gly Arg Ser Gly Gly Lys Arg Val Leu Val Arg Asp 
65                  70                  75                  80  


Ile Ser Glu Tyr Thr Ala Asp Phe Asp Thr Leu Val Gly Ile Ala Thr 
                85                  90                  95      


Arg Glu Tyr Pro Gly Cys Lys Arg Ile Val Leu Gly His Ser Met Gly 
            100                 105                 110         


Gly Gly Ile Val Phe Ala Tyr Gly Val Glu Arg Pro Asp Asn Tyr Asp 
        115                 120                 125             


Leu Met Val Leu Ser Ala Pro Ala Val Ala Ala Gln Asp Leu Val Ser 
    130                 135                 140                 


Pro Val Val Ala Val Ala Ala Lys Leu Leu Gly Val Val Val Pro Gly 
145                 150                 155                 160 


Leu Pro Val Gln Glu Leu Asp Phe Thr Ala Ile Ser Arg Asp Pro Glu 
                165                 170                 175     


Val Val Gln Ala Tyr Asn Thr Asp Pro Leu Val His His Gly Arg Val 
            180                 185                 190         


Pro Ala Gly Ile Gly Arg Ala Leu Leu Gln Val Gly Glu Thr Met Pro 
        195                 200                 205             


Arg Arg Ala Pro Ala Leu Thr Ala Pro Leu Leu Val Leu His Gly Thr 
    210                 215                 220                 


Asp Asp Arg Leu Ile Pro Ile Glu Gly Ser Arg Arg Leu Val Glu Cys 
225                 230                 235                 240 


Val Gly Ser Ala Asp Val Gln Leu Lys Glu Tyr Pro Gly Leu Tyr His 
                245                 250                 255     


Glu Val Phe Asn Glu Pro Glu Arg Asn Gln Val Leu Asp Asp Val Val 
            260                 265                 270         


Ala Trp Leu Thr Glu Arg Leu 
        275                 


<210>  5
<211>  512
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  5

Met Ser Arg Arg Glu Phe Leu Thr Lys Leu Thr Gly Ala Gly Ala Ala 
1               5                   10                  15      


Ala Phe Leu Met Asp Trp Ala Ala Pro Val Ile Glu Lys Ala Tyr Gly 
            20                  25                  30          


Ala Gly Pro Cys Pro Gly His Leu Thr Asp Ile Glu His Ile Val Leu 
        35                  40                  45              


Leu Met Gln Glu Asn Arg Ser Phe Asp His Tyr Phe Gly Thr Leu Ser 
    50                  55                  60                  


Ser Thr Asn Gly Phe Asn Ala Ala Ser Pro Ala Phe Gln Gln Met Gly 
65                  70                  75                  80  


Trp Asn Pro Met Thr Gln Ala Leu Asp Pro Ala Gly Val Thr Ile Pro 
                85                  90                  95      


Phe Arg Leu Asp Thr Thr Arg Gly Pro Phe Leu Asp Gly Glu Cys Val 
            100                 105                 110         


Asn Asp Pro Glu His Gln Trp Val Gly Met His Leu Ala Trp Asn Gly 
        115                 120                 125             


Gly Ala Asn Asp Asn Trp Leu Pro Ala Gln Ala Thr Thr Arg Ala Gly 
    130                 135                 140                 


Pro Tyr Val Pro Leu Thr Met Gly Tyr Tyr Thr Arg Gln Asp Ile Pro 
145                 150                 155                 160 


Ile His Tyr Leu Leu Ala Asp Thr Phe Thr Ile Cys Asp Gly Tyr His 
                165                 170                 175     


Cys Ser Leu Leu Thr Gly Thr Leu Pro Asn Arg Leu Tyr Trp Leu Ser 
            180                 185                 190         


Ala Asn Ile Asp Pro Ala Gly Thr Asp Gly Gly Pro Gln Leu Val Glu 
        195                 200                 205             


Pro Gly Phe Leu Pro Leu Gln Gln Phe Ser Trp Arg Ile Met Pro Glu 
    210                 215                 220                 


Asn Leu Glu Asp Ala Gly Val Ser Trp Lys Val Tyr Gln Asn Lys Gly 
225                 230                 235                 240 


Leu Gly Arg Phe Ile Asn Thr Pro Ile Ser Asn Asn Gly Leu Val Gln 
                245                 250                 255     


Ala Phe Arg Gln Ala Ala Asp Pro Arg Ser Asn Leu Ala Arg Tyr Gly 
            260                 265                 270         


Ile Ala Pro Thr Tyr Pro Gly Asp Phe Ala Ala Asp Val Arg Ala Asn 
        275                 280                 285             


Arg Leu Pro Lys Val Ser Trp Leu Val Pro Asn Ile Leu Gln Ser Glu 
    290                 295                 300                 


His Pro Ala Leu Pro Val Ala Leu Gly Ala Val Ser Met Val Thr Ala 
305                 310                 315                 320 


Leu Arg Ile Leu Leu Ser Asn Pro Ala Val Trp Glu Lys Thr Ala Leu 
                325                 330                 335     


Ile Val Ser Tyr Asp Glu Asn Gly Gly Phe Phe Asp His Val Thr Pro 
            340                 345                 350         


Pro Thr Ala Pro Pro Gly Thr Pro Gly Glu Phe Val Thr Val Pro Asn 
        355                 360                 365             


Ile Asp Ala Val Pro Gly Ser Gly Gly Ile Arg Gly Pro Leu Gly Leu 
    370                 375                 380                 


Gly Phe Arg Val Pro Cys Ile Val Ile Ser Pro Tyr Ser Arg Gly Pro 
385                 390                 395                 400 


Leu Met Val Ser Asp Thr Phe Asp His Thr Ser Gln Leu Lys Leu Ile 
                405                 410                 415     


Arg Ala Arg Phe Gly Val Pro Val Pro Asn Met Thr Ala Trp Arg Asp 
            420                 425                 430         


Gly Val Val Gly Asp Met Thr Ser Ala Phe Asn Phe Ala Thr Pro Pro 
        435                 440                 445             


Asn Ser Thr Arg Pro Asn Leu Ser His Pro Leu Leu Gly Ala Leu Pro 
    450                 455                 460                 


Lys Leu Pro Gln Cys Ile Pro Asn Val Val Leu Gly Thr Thr Asp Gly 
465                 470                 475                 480 


Ala Leu Pro Ser Ile Pro Tyr Arg Val Pro Tyr Pro Gln Val Met Pro 
                485                 490                 495     


Thr Gln Glu Thr Thr Pro Val Arg Gly Thr Pro Ser Gly Leu Cys Ser 
            500                 505                 510         


<210>  6
<211>  512
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  6

Met Thr Arg Arg Gln Phe Phe Ala Lys Ala Ala Ala Ala Thr Thr Ala 
1               5                   10                  15      


Gly Ala Phe Met Ser Leu Ala Gly Pro Ile Ile Glu Lys Ala Tyr Gly 
            20                  25                  30          


Ala Gly Pro Cys Pro Gly His Leu Thr Asp Ile Glu His Ile Val Leu 
        35                  40                  45              


Leu Met Gln Glu Asn Arg Ser Phe Asp His Tyr Phe Gly Thr Leu Ser 
    50                  55                  60                  


Asp Thr Arg Gly Phe Asp Asp Thr Thr Pro Pro Val Val Phe Ala Gln 
65                  70                  75                  80  


Ser Gly Trp Asn Pro Met Thr Gln Ala Val Asp Pro Ala Gly Val Thr 
                85                  90                  95      


Leu Pro Tyr Arg Phe Asp Thr Thr Arg Gly Pro Leu Val Ala Gly Glu 
            100                 105                 110         


Cys Val Asn Asp Pro Asp His Ser Trp Ile Gly Met His Asn Ser Trp 
        115                 120                 125             


Asn Gly Gly Ala Asn Asp Asn Trp Leu Pro Ala Gln Val Pro Phe Ser 
    130                 135                 140                 


Pro Leu Gln Gly Asn Val Pro Val Thr Met Gly Phe Tyr Thr Arg Arg 
145                 150                 155                 160 


Asp Leu Pro Ile His Tyr Leu Leu Ala Asp Thr Phe Thr Val Cys Asp 
                165                 170                 175     


Gly Tyr Phe Cys Ser Leu Leu Gly Gly Thr Thr Pro Asn Arg Leu Tyr 
            180                 185                 190         


Trp Met Ser Ala Trp Ile Asp Pro Asp Gly Thr Asp Gly Gly Pro Val 
        195                 200                 205             


Leu Ile Glu Pro Asn Ile Gln Pro Leu Gln His Tyr Ser Trp Arg Ile 
    210                 215                 220                 


Met Pro Glu Asn Leu Glu Asp Ala Gly Val Ser Trp Lys Val Tyr Gln 
225                 230                 235                 240 


Asn Lys Leu Leu Gly Ala Leu Asn Asn Thr Val Val Gly Tyr Asn Gly 
                245                 250                 255     


Leu Val Asn Asp Phe Lys Gln Ala Ala Asp Pro Arg Ser Asn Leu Ala 
            260                 265                 270         


Arg Phe Gly Ile Ser Pro Thr Tyr Pro Leu Asp Phe Ala Ala Asp Val 
        275                 280                 285             


Arg Asn Asn Arg Leu Pro Lys Val Ser Trp Val Leu Pro Gly Phe Leu 
    290                 295                 300                 


Leu Ser Glu His Pro Ala Phe Pro Val Asn Val Gly Ala Val Ala Ile 
305                 310                 315                 320 


Val Asp Ala Leu Arg Ile Leu Leu Ser Asn Pro Ala Val Trp Glu Lys 
                325                 330                 335     


Thr Ala Leu Ile Val Asn Tyr Asp Glu Asn Gly Gly Phe Phe Asp His 
            340                 345                 350         


Val Val Pro Pro Thr Pro Pro Pro Gly Thr Pro Gly Glu Phe Val Thr 
        355                 360                 365             


Val Pro Asp Ile Asp Ser Val Pro Gly Ser Gly Gly Ile Arg Gly Pro 
    370                 375                 380                 


Ile Gly Leu Gly Phe Arg Val Pro Cys Leu Val Ile Ser Pro Tyr Ser 
385                 390                 395                 400 


Arg Gly Pro Leu Met Val His Asp Thr Phe Asp His Thr Ser Thr Leu 
                405                 410                 415     


Lys Leu Ile Arg Ala Arg Phe Gly Val Pro Val Pro Asn Leu Thr Ala 
            420                 425                 430         


Trp Arg Asp Ala Thr Val Gly Asp Met Thr Ser Thr Phe Asn Phe Ala 
        435                 440                 445             


Ala Pro Pro Asn Pro Ser Lys Pro Asn Leu Asp His Pro Arg Leu Asn 
    450                 455                 460                 


Ala Leu Pro Lys Leu Pro Gln Cys Val Pro Asn Ala Val Leu Gly Thr 
465                 470                 475                 480 


Val Thr Lys Thr Ala Ile Pro Tyr Arg Val Pro Phe Pro Gln Ser Met 
                485                 490                 495     


Pro Thr Gln Glu Thr Ala Pro Thr Arg Gly Ile Pro Ser Gly Leu Cys 
            500                 505                 510         


<210>  7
<211>  508
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  7

Met Ser Arg Arg Ala Phe Leu Ala Lys Ala Ala Gly Ala Gly Ala Ala 
1               5                   10                  15      


Ala Val Leu Thr Asp Trp Ala Ala Pro Val Ile Glu Lys Ala Tyr Gly 
            20                  25                  30          


Ala Gly Pro Cys Ser Gly His Leu Thr Asp Ile Glu His Ile Val Leu 
        35                  40                  45              


Cys Leu Gln Glu Asn Arg Ser Phe Asp His Tyr Phe Gly Thr Leu Ser 
    50                  55                  60                  


Ala Val Asp Gly Phe Asp Thr Pro Thr Pro Leu Phe Gln Gln Lys Gly 
65                  70                  75                  80  


Trp Asn Pro Glu Thr Gln Ala Leu Asp Pro Thr Gly Ile Thr Leu Pro 
                85                  90                  95      


Tyr Arg Ile Asn Thr Thr Gly Gly Pro Asn Gly Val Gly Glu Cys Val 
            100                 105                 110         


Asn Asp Pro Asp His Gln Trp Ile Ala Ala His Leu Ser Trp Asn Gly 
        115                 120                 125             


Gly Ala Asn Asp Gly Trp Leu Pro Ala Gln Ala Arg Thr Arg Ser Val 
    130                 135                 140                 


Ala Asn Thr Pro Val Val Met Gly Tyr Tyr Ala Arg Pro Asp Ile Pro 
145                 150                 155                 160 


Ile His Tyr Leu Leu Ala Asp Thr Phe Thr Ile Cys Asp Gln Tyr Phe 
                165                 170                 175     


Ser Ser Leu Leu Gly Gly Thr Met Pro Asn Arg Leu Tyr Trp Ile Ser 
            180                 185                 190         


Ala Thr Val Asn Pro Asp Gly Asp Gln Gly Gly Pro Gln Ile Val Glu 
        195                 200                 205             


Pro Ala Ile Gln Pro Lys Leu Thr Phe Thr Trp Arg Ile Met Pro Gln 
    210                 215                 220                 


Asn Leu Ser Asp Ala Gly Ile Ser Trp Lys Val Tyr Asn Ser Lys Leu 
225                 230                 235                 240 


Leu Gly Gly Leu Asn Asp Thr Ser Leu Ser Arg Asn Gly Tyr Val Gly 
                245                 250                 255     


Ser Phe Lys Gln Ala Ala Asp Pro Arg Ser Asp Leu Ala Arg Tyr Gly 
            260                 265                 270         


Ile Ala Pro Ala Tyr Pro Trp Asp Phe Ile Arg Asp Val Ile Asn Asn 
        275                 280                 285             


Thr Leu Pro Gln Val Ser Trp Val Val Pro Leu Thr Val Glu Ser Glu 
    290                 295                 300                 


His Pro Ser Phe Pro Val Ala Val Gly Ala Val Thr Ile Val Asn Leu 
305                 310                 315                 320 


Ile Arg Val Leu Leu Arg Asn Pro Ala Val Trp Glu Lys Thr Ala Leu 
                325                 330                 335     


Ile Ile Ala Tyr Asp Glu His Gly Gly Phe Phe Asp His Val Thr Pro 
            340                 345                 350         


Leu Thr Ala Pro Glu Gly Thr Pro Gly Glu Trp Ile Pro Asn Ser Val 
        355                 360                 365             


Asp Ile Asp Lys Val Asp Gly Ser Gly Gly Ile Arg Gly Pro Ile Gly 
    370                 375                 380                 


Leu Gly Phe Arg Val Pro Cys Phe Val Ile Ser Pro Tyr Ser Arg Gly 
385                 390                 395                 400 


Gly Leu Met Val His Asp Arg Phe Asp His Thr Ser Gln Leu Gln Leu 
                405                 410                 415     


Ile Gly Lys Arg Phe Gly Val Pro Val Pro Asn Leu Thr Pro Trp Arg 
            420                 425                 430         


Ala Ser Val Thr Gly Asp Met Thr Ser Ala Phe Asn Phe Ala Ala Pro 
        435                 440                 445             


Pro Asp Pro Ser Pro Pro Asn Leu Asp His Pro Val Arg Gln Leu Pro 
    450                 455                 460                 


Lys Val Ala Lys Cys Val Pro Asn Val Val Leu Gly Phe Leu Asn Glu 
465                 470                 475                 480 


Gly Leu Pro Tyr Arg Val Pro Tyr Pro Gln Thr Thr Pro Val Gln Glu 
                485                 490                 495     


Ser Gly Pro Ala Arg Pro Ile Pro Ser Gly Ile Cys 
            500                 505             


<210>  8
<211>  280
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  8

Asp Ala Gly Val Ser Trp Lys Val Tyr Arg Asn Lys Thr Leu Gly Pro 
1               5                   10                  15      


Ile Ser Ser Val Leu Thr Tyr Gly Ser Leu Val Thr Ser Phe Lys Gln 
            20                  25                  30          


Ser Ala Asp Pro Arg Ser Asp Leu Val Arg Phe Gly Val Ala Pro Ser 
        35                  40                  45              


Tyr Pro Ala Ser Phe Ala Ala Asp Val Leu Ala Asn Arg Leu Pro Arg 
    50                  55                  60                  


Val Ser Trp Val Ile Pro Asn Val Leu Glu Ser Glu His Pro Ala Val 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Phe Ala Ile Val Asn Ile Leu Arg Ile Leu 
                85                  90                  95      


Leu Ala Asn Pro Ala Val Trp Glu Lys Thr Ala Leu Ile Val Ser Tyr 
            100                 105                 110         


Asp Glu Asn Gly Gly Phe Phe Asp His Val Val Pro Ala Thr Ala Pro 
        115                 120                 125             


Ala Gly Thr Pro Gly Glu Tyr Val Thr Val Pro Asp Ile Asp Gln Val 
    130                 135                 140                 


Pro Gly Ser Gly Gly Ile Arg Gly Pro Ile Gly Leu Gly Phe Arg Val 
145                 150                 155                 160 


Pro Cys Phe Val Ile Ser Pro Tyr Ser Arg Gly Pro Gln Met Val His 
                165                 170                 175     


Asp Thr Phe Asp His Thr Ser Gln Leu Arg Leu Leu Glu Thr Arg Phe 
            180                 185                 190         


Gly Val Pro Val Pro Asn Leu Thr Ala Trp Arg Arg Ser Val Thr Gly 
        195                 200                 205             


Asp Met Thr Ser Thr Phe Asn Phe Ala Val Pro Pro Asn Ser Ser Trp 
    210                 215                 220                 


Pro Asn Leu Asp Tyr Pro Gly Leu His Ala Leu Ser Thr Val Pro Gln 
225                 230                 235                 240 


Cys Val Pro Asn Ala Ala Leu Gly Thr Ile Asn Arg Gly Ile Pro Tyr 
                245                 250                 255     


Arg Val Pro Asp Pro Gln Ile Met Pro Thr Gln Glu Thr Thr Pro Thr 
            260                 265                 270         


Arg Gly Ile Pro Ser Gly Pro Cys 
        275                 280 


<210>  9
<211>  514
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  9

Met Ser Gln Ser His Ile Gly Gly Val Ser Arg Arg Glu Phe Leu Ala 
1               5                   10                  15      


Lys Val Ala Ala Gly Gly Ala Gly Ala Leu Met Ser Phe Ala Gly Pro 
            20                  25                  30          


Val Ile Glu Lys Ala Tyr Gly Ala Gly Pro Cys Ser Gly His Leu Thr 
        35                  40                  45              


Asp Ile Glu His Phe Val Phe Phe Met Gln Glu Asn Arg Ser Phe Asp 
    50                  55                  60                  


His Tyr Phe Gly Thr Leu Ser Gly Thr Asp Gly Phe Asn Thr Val Ser 
65                  70                  75                  80  


Pro Leu Phe Gln Gln Lys Gly Trp Asn Pro Met Thr Gln Ala Leu Asp 
                85                  90                  95      


Ala Thr Gly Val Thr Met Pro Tyr Arg Phe Asp Thr Thr Arg Gly Pro 
            100                 105                 110         


Phe Leu Asp Gly Ala Cys Val Asn Asp Pro Asp His Ser Trp Val Ala 
        115                 120                 125             


Met His Glu Ser Trp Asn Gly Gly Val Asn Asp Asn Trp Leu Pro Ala 
    130                 135                 140                 


Gln Ala Lys Thr Arg Ser Ala Ala His Thr Pro Thr Val Met Gly Tyr 
145                 150                 155                 160 


Tyr Thr Arg Gln Asp Ile Pro Ile His Tyr Leu Leu Ala Asp Ala Phe 
                165                 170                 175     


Thr Val Cys Asp Arg Tyr Phe Cys Ser Val Leu Gly Pro Thr Leu Pro 
            180                 185                 190         


Asn Arg Leu Tyr Trp Leu Ser Ala Thr Ile Asp Pro Asp Gly Gln Asn 
        195                 200                 205             


Gly Gly Pro Glu Leu Gln Ser Pro Thr Phe Gln Pro Val Arg Arg Phe 
    210                 215                 220                 


Gly Trp Arg Ile Met Pro Gln Asn Leu Ser Asp Ala Gly Val Ser Trp 
225                 230                 235                 240 


Lys Val Tyr Arg Asn Lys Thr Leu Gly Pro Ile Ser Ser Val Leu Thr 
                245                 250                 255     


Tyr Gly Ser Leu Val Thr Ser Phe Lys Gln Ser Ala Asp Pro Arg Ser 
            260                 265                 270         


Asp Leu Val Arg Phe Gly Val Ala Pro Ser Tyr Pro Ala Ser Phe Ala 
        275                 280                 285             


Ala Asp Val Leu Ala Asn Arg Leu Pro Arg Val Ser Trp Val Ile Pro 
    290                 295                 300                 


Asn Val Leu Glu Ser Glu His Pro Ala Val Pro Ala Ala Ala Gly Ala 
305                 310                 315                 320 


Phe Ala Ile Val Asn Ile Leu Arg Ile Leu Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Trp Glu Lys Thr Ala Leu Ile Val Ser Tyr Asp Glu Asn Gly Gly Phe 
            340                 345                 350         


Phe Asp His Val Val Pro Ala Thr Ala Pro Ala Gly Thr Pro Gly Glu 
        355                 360                 365             


Tyr Val Thr Val Pro Asp Ile Asp Gln Val Pro Gly Ser Gly Gly Ile 
    370                 375                 380                 


Arg Gly Pro Ile Gly Leu Gly Phe Arg Val Pro Cys Phe Val Ile Ser 
385                 390                 395                 400 


Pro Tyr Ser Arg Gly Pro Gln Met Val His Asp Thr Phe Asp His Thr 
                405                 410                 415     


Ser Gln Leu Arg Leu Leu Glu Thr Arg Phe Gly Val Pro Val Pro Asn 
            420                 425                 430         


Leu Thr Ala Trp Arg Arg Ser Val Thr Gly Asp Met Thr Ser Thr Phe 
        435                 440                 445             


Asn Phe Ala Val Pro Pro Asn Ser Ser Trp Pro Asn Leu Asp Tyr Pro 
    450                 455                 460                 


Gly Leu His Ala Leu Ser Thr Val Pro Gln Cys Val Pro Asn Ala Ala 
465                 470                 475                 480 


Leu Gly Thr Ile Asn Arg Gly Ile Pro Tyr Arg Val Pro Asp Pro Gln 
                485                 490                 495     


Ile Met Pro Thr Gln Glu Thr Thr Pro Thr Arg Gly Ile Pro Ser Gly 
            500                 505                 510         


Pro Cys 
        


<210>  10
<211>  336
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  10

Met Ala Lys Asn Ser Arg Arg Lys Arg His Arg Ile Leu Ala Trp Ile 
1               5                   10                  15      


Ala Ala Gly Ala Met Ala Ser Val Val Ala Leu Val Ile Val Ala Val 
            20                  25                  30          


Val Ile Met Leu Arg Gly Ala Glu Ser Pro Pro Ser Ala Val Pro Pro 
        35                  40                  45              


Gly Val Leu Pro Pro Gly Pro Thr Pro Ala His Pro His Lys Pro Arg 
    50                  55                  60                  


Pro Ala Phe Gln Asp Ala Ser Cys Pro Asp Val Gln Met Ile Ser Val 
65                  70                  75                  80  


Pro Gly Thr Trp Glu Ser Ser Pro Gln Gln Asn Pro Leu Asn Pro Val 
                85                  90                  95      


Gln Phe Pro Lys Ala Leu Leu Leu Lys Val Thr Gly Pro Ile Ala Gln 
            100                 105                 110         


Gln Phe Ala Pro Ala Arg Val Gln Thr Tyr Thr Val Ala Tyr Thr Ala 
        115                 120                 125             


Gln Phe His Asn Pro Leu Thr Thr Asp Asn Gln Met Ser Tyr Asn Asp 
    130                 135                 140                 


Ser Arg Ala Glu Gly Thr Arg Ala Met Val Ala Ala Met Thr Asp Met 
145                 150                 155                 160 


Asn Asn Arg Cys Pro Leu Thr Ser Tyr Val Leu Ile Gly Phe Ser Gln 
                165                 170                 175     


Gly Ala Val Ile Ala Gly Asp Val Ala Ser Asp Ile Gly Asn Gly Arg 
            180                 185                 190         


Gly Pro Val Asp Glu Asp Leu Val Leu Gly Val Thr Leu Ile Ala Asp 
        195                 200                 205             


Gly Arg Arg Gln Gln Gly Val Gly Asn Gln Val Pro Pro Ser Pro Arg 
    210                 215                 220                 


Gly Glu Gly Ala Glu Ile Thr Leu His Glu Val Pro Val Leu Ser Gly 
225                 230                 235                 240 


Leu Gly Leu Thr Met Thr Gly Pro Arg Pro Gly Gly Phe Gly Ala Leu 
                245                 250                 255     


Asp Gly Arg Thr Asn Glu Ile Cys Ala Gln Gly Asp Leu Ile Cys Ala 
            260                 265                 270         


Ala Pro Ala Gln Ala Phe Ser Pro Ala Asn Leu Pro Thr Thr Leu Asn 
        275                 280                 285             


Thr Leu Ala Gly Gly Ala Gly Gln Pro Val His Ala Met Tyr Ala Thr 
    290                 295                 300                 


Pro Glu Phe Trp Asn Ser Asp Gly Glu Pro Ala Thr Glu Trp Thr Leu 
305                 310                 315                 320 


Asn Trp Ala His Gln Leu Ile Glu Asn Ala Pro His Pro Lys His Arg 
                325                 330                 335     


