                               SEQUENCE LISTING

<110> AMYLIN PHARMACEUTICALS, INC.
 
<120> AMYLIN PEPTIDES AND DERIVATIVES AND USES THEREOF

<130> 0123WO1

<140>
<141>

<150> 61/489,781
<151> 2011-05-25

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 37
<212> PRT
<213> Rattus sp.

<400> 1
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 2
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 3
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 4
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term is hydrogen, an N-terminal capping group, 
      a bond to a duration enhancing moiety, or a linker 
      to a duration enhancing moiety 

<220>
<221> MOD_RES
<222> (1)..(1)
<223> May or may not be present

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Lys, Cys, or His 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Lys, Cys, or Asn 

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys, Cys, or Gly 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys, Cys, or Pro 

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Lys, Cys, or Ile 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Lys, Cys, or Leu 

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Lys, Cys, or Pro 

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Lys, Cys, or Asn 

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Lys, Cys, or Ser 

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Lys, Cys, or Asn 

<220>
<223> C-term substituted or unsubstituted amino, substituted or 
      unsubstituted alkylamino, substituted or unsubstituted 
      dialkylamino, substituted or unsubstituted cycloalkylamino, 
      substituted or unsubstituted arylamino, substituted or 

<220>
<223> cont. from above; unsubstituted aralkylamino, substituted or 
      unsubstituted alkyloxy, substituted or unsubstituted aryloxy, 
      substituted or unsubstituted aralkyloxy, hydroxyl, or a bond 
      or linker to a duration enhancing moiety 

<400> 4
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Xaa Ser Ser Xaa Asn Phe Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Val 
            20                  25                  30          


Gly Xaa Xaa Thr Tyr 
        35          


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Gly Gly Gly 
1               


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Gly Gly Gly Gly 
1               5   


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence0123WO1

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Gly Gly Lys Gly Gly Gly Gly 
1               5               


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Gly Gly Asn Gly Ser Gly Gly 
1               5               


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gly Gly Gly Cys Gly Gly Gly Gly 
1               5               


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Pro Asn Gly Gly 
1               5   


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(12)
<223> This sequence may encompass 1, 2, 3, 4, 5, or 6 
      "Gly Ser" repeating units 

<400> 11
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(18)
<223> This sequence may encompass 1, 2, 3, 4, 5, or 6 
      "Gly Gly Ser" repeating units 

<400> 12
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 13
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(24)
<223> This sequence may encompass 1, 2, 3, 4, 5, or 6 
      "Gly Gly Gly Ser" repeating units 

<400> 13
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210> 14
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(30)
<223> This sequence may encompass 1, 2, 3, 4, 5, or 6 
      "Gly Gly Gly Gly Ser" repeating units 

<400> 14
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 16
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 16
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          

<210> 17
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 17
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 18
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 18
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Lys Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 19
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 19
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Lys Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 20
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 20
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Lys Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 21
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 21
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 22
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 22
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Lys Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 23
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 23
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Lys Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 24
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 24
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 25
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 25
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 26
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2


<400> 26
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Lys Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 27
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 27
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 28
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 28
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Lys Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 29
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 29
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Lys Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 30
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 30
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 31
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 31
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Lys Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 32
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 32
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Lys Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 33
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 33
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Lys Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 34
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 34
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Lys Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 35
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 35
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Lys Asn Thr Tyr 
        35      


<210> 36
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> C-term NH2

<400> 36
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Lys Thr Tyr 
        35      


<210> 37
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term mPEG40KD

<220>
<223> C-term NH2

<400> 37
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 38
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term mPEG40KD

<220>
<223> C-term NH2

<400> 38
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 39
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 39
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Lys Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 40
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 40
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Lys Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 41
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 41
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Lys Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 42
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 42
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 43
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 43
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Lys Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 44
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 44
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Lys Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 45
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Lys(Y-shaped-mPEG40KD)

<220>
<223> C-term NH2

<400> 45
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Lys Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 46
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 46
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Lys Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 47
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 47
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 48
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 48
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Lys Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 49
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Lys(Y-shaped-mPEG40KD)

<220>
<223> C-term NH2

<400> 49
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 50
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 50
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Lys Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 51
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 51
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Lys Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 52
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 52
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Lys Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 53
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 53
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Lys Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 54
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 54
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Lys Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 55
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 55
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


Lys Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Asn Thr Tyr 
        35      


<210> 56
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 56
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Lys Asn Thr Tyr 
        35      


<210> 57
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Lys(mPEG40KD)

<220>
<223> C-term NH2

<400> 57
Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val 
1               5                   10                  15      


His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Lys Thr Tyr 
        35      



