                         SEQUENCE LISTING

<110>  Cell Signaling Technology, Inc.
 
<120>  ROS KINASE IN LUNG CANCER

<130>  28119

<140>  13/113,676
<141>  2012-03-05

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  2347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Met Lys Asn Ile Tyr Cys Leu Ile Pro Lys Leu Val Asn Phe Ala Thr 
1               5                   10                  15      


Leu Gly Cys Leu Trp Ile Ser Val Val Gln Cys Thr Val Leu Asn Ser 
            20                  25                  30          


Cys Leu Lys Ser Cys Val Thr Asn Leu Gly Gln Gln Leu Asp Leu Gly 
        35                  40                  45              


Thr Pro His Asn Leu Ser Glu Pro Cys Ile Gln Gly Cys His Phe Trp 
    50                  55                  60                  


Asn Ser Val Asp Gln Lys Asn Cys Ala Leu Lys Cys Arg Glu Ser Cys 
65                  70                  75                  80  


Glu Val Gly Cys Ser Ser Ala Glu Gly Ala Tyr Glu Glu Glu Val Leu 
                85                  90                  95      


Glu Asn Ala Asp Leu Pro Thr Ala Pro Phe Ala Ser Ser Ile Gly Ser 
            100                 105                 110         


His Asn Met Thr Leu Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys 
        115                 120                 125             


Tyr Ile Ile Gln Trp Lys Tyr Ala Gln Leu Leu Gly Ser Trp Thr Tyr 
    130                 135                 140                 


Thr Lys Thr Val Ser Arg Pro Ser Tyr Val Val Lys Pro Leu His Pro 
145                 150                 155                 160 


Phe Thr Glu Tyr Ile Phe Arg Val Val Trp Ile Phe Thr Ala Gln Leu 
                165                 170                 175     


Gln Leu Tyr Ser Pro Pro Ser Pro Ser Tyr Arg Thr His Pro His Gly 
            180                 185                 190         


Val Pro Glu Thr Ala Pro Leu Ile Arg Asn Ile Glu Ser Ser Ser Pro 
        195                 200                 205             


Asp Thr Val Glu Val Ser Trp Asp Pro Pro Gln Phe Pro Gly Gly Pro 
    210                 215                 220                 


Ile Leu Gly Tyr Asn Leu Arg Leu Ile Ser Lys Asn Gln Lys Leu Asp 
225                 230                 235                 240 


Ala Gly Thr Gln Arg Thr Ser Phe Gln Phe Tyr Ser Thr Leu Pro Asn 
                245                 250                 255     


Thr Ile Tyr Arg Phe Ser Ile Ala Ala Val Asn Glu Val Gly Glu Gly 
            260                 265                 270         


Pro Glu Ala Glu Ser Ser Ile Thr Thr Ser Ser Ser Ala Val Gln Gln 
        275                 280                 285             


Glu Glu Gln Trp Leu Phe Leu Ser Arg Lys Thr Ser Leu Arg Lys Arg 
    290                 295                 300                 


Ser Leu Lys His Leu Val Asp Glu Ala His Cys Leu Arg Leu Asp Ala 
305                 310                 315                 320 


Ile Tyr His Asn Ile Thr Gly Ile Ser Val Asp Val His Gln Gln Ile 
                325                 330                 335     


Val Tyr Phe Ser Glu Gly Thr Leu Ile Trp Ala Lys Lys Ala Ala Asn 
            340                 345                 350         


Met Ser Asp Val Ser Asp Leu Arg Ile Phe Tyr Arg Gly Ser Gly Leu 
        355                 360                 365             


Ile Ser Ser Ile Ser Ile Asp Trp Leu Tyr Gln Arg Met Tyr Phe Ile 
    370                 375                 380                 


Met Asp Glu Leu Val Cys Val Cys Asp Leu Glu Asn Cys Ser Asn Ile 
385                 390                 395                 400 


Glu Glu Ile Thr Pro Pro Ser Ile Ser Ala Pro Gln Lys Ile Val Ala 
                405                 410                 415     


Asp Ser Tyr Asn Gly Tyr Val Phe Tyr Leu Leu Arg Asp Gly Ile Tyr 
            420                 425                 430         


Arg Ala Asp Leu Pro Val Pro Ser Gly Arg Cys Ala Glu Ala Val Arg 
        435                 440                 445             


Ile Val Glu Ser Cys Thr Leu Lys Asp Phe Ala Ile Lys Pro Gln Ala 
    450                 455                 460                 


Lys Arg Ile Ile Tyr Phe Asn Asp Thr Ala Gln Val Phe Met Ser Thr 
465                 470                 475                 480 


Phe Leu Asp Gly Ser Ala Ser His Leu Ile Leu Pro Arg Ile Pro Phe 
                485                 490                 495     


Ala Asp Val Lys Ser Phe Ala Cys Glu Asn Asn Asp Phe Leu Val Thr 
            500                 505                 510         


Asp Gly Lys Val Ile Phe Gln Gln Asp Ala Leu Ser Phe Asn Glu Phe 
        515                 520                 525             


Ile Val Gly Cys Asp Leu Ser His Ile Glu Glu Phe Gly Phe Gly Asn 
    530                 535                 540                 


Leu Val Ile Phe Gly Ser Ser Ser Gln Leu His Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Pro Gln Glu Leu Ser Val Leu Phe Gly Ser His Gln Ala Leu Val Gln 
                565                 570                 575     


Trp Lys Pro Pro Ala Leu Ala Ile Gly Ala Asn Val Ile Leu Ile Ser 
            580                 585                 590         


Asp Ile Ile Glu Leu Phe Glu Leu Gly Pro Ser Ala Trp Gln Asn Trp 
        595                 600                 605             


Thr Tyr Glu Val Lys Val Ser Thr Gln Asp Pro Pro Glu Val Thr His 
    610                 615                 620                 


Ile Phe Leu Asn Ile Ser Gly Thr Met Leu Asn Val Pro Glu Leu Gln 
625                 630                 635                 640 


Ser Ala Met Lys Tyr Lys Val Ser Val Arg Ala Ser Ser Pro Lys Arg 
                645                 650                 655     


Pro Gly Pro Trp Ser Glu Pro Ser Val Gly Thr Thr Leu Val Pro Ala 
            660                 665                 670         


Ser Glu Pro Pro Phe Ile Met Ala Val Lys Glu Asp Gly Leu Trp Ser 
        675                 680                 685             


Lys Pro Leu Asn Ser Phe Gly Pro Gly Glu Phe Leu Ser Ser Asp Ile 
    690                 695                 700                 


Gly Asn Val Ser Asp Met Asp Trp Tyr Asn Asn Ser Leu Tyr Tyr Ser 
705                 710                 715                 720 


Asp Thr Lys Gly Asp Val Phe Val Trp Leu Leu Asn Gly Thr Asp Ile 
                725                 730                 735     


Ser Glu Asn Tyr His Leu Pro Ser Ile Ala Gly Ala Gly Ala Leu Ala 
            740                 745                 750         


Phe Glu Trp Leu Gly His Phe Leu Tyr Trp Ala Gly Lys Thr Tyr Val 
        755                 760                 765             


Ile Gln Arg Gln Ser Val Leu Thr Gly His Thr Asp Ile Val Thr His 
    770                 775                 780                 


Val Lys Leu Leu Val Asn Asp Met Val Val Asp Ser Val Gly Gly Tyr 
785                 790                 795                 800 


Leu Tyr Trp Thr Thr Leu Tyr Ser Val Glu Ser Thr Arg Leu Asn Gly 
                805                 810                 815     


Glu Ser Ser Leu Val Leu Gln Thr Gln Pro Trp Phe Ser Gly Lys Lys 
            820                 825                 830         


Val Ile Ala Leu Thr Leu Asp Leu Ser Asp Gly Leu Leu Tyr Trp Leu 
        835                 840                 845             


Val Gln Asp Ser Gln Cys Ile His Leu Tyr Thr Ala Val Leu Arg Gly 
    850                 855                 860                 


Gln Ser Thr Gly Asp Thr Thr Ile Thr Glu Phe Ala Ala Trp Ser Thr 
865                 870                 875                 880 


Ser Glu Ile Ser Gln Asn Ala Leu Met Tyr Tyr Ser Gly Arg Leu Phe 
                885                 890                 895     


Trp Ile Asn Gly Phe Arg Ile Ile Thr Thr Gln Glu Ile Gly Gln Lys 
            900                 905                 910         


Thr Ser Val Ser Val Leu Glu Pro Ala Arg Phe Asn Gln Phe Thr Ile 
        915                 920                 925             


Ile Gln Thr Ser Leu Lys Pro Leu Pro Gly Asn Phe Ser Phe Thr Pro 
    930                 935                 940                 


Lys Val Ile Pro Asp Ser Val Gln Glu Ser Ser Phe Arg Ile Glu Gly 
945                 950                 955                 960 


Asn Ala Ser Ser Phe Gln Ile Leu Trp Asn Gly Pro Pro Ala Val Asp 
                965                 970                 975     


Trp Gly Val Val Phe Tyr Ser Val Glu Phe Ser Ala His Ser Lys Phe 
            980                 985                 990         


Leu Ala Ser Glu Gln His Ser Leu  Pro Val Phe Thr Val  Glu Gly Leu 
        995                 1000                 1005             


Glu Pro  Tyr Ala Leu Phe Asn  Leu Ser Val Thr Pro  Tyr Thr Tyr 
    1010                 1015                 1020             


Trp Gly  Lys Gly Pro Lys Thr  Ser Leu Ser Leu Arg  Ala Pro Glu 
    1025                 1030                 1035             


Thr Val  Pro Ser Ala Pro Glu  Asn Pro Arg Ile Phe  Ile Leu Pro 
    1040                 1045                 1050             


Ser Gly  Lys Cys Cys Asn Lys  Asn Glu Val Val Val  Glu Phe Arg 
    1055                 1060                 1065             


Trp Asn  Lys Pro Lys His Glu  Asn Gly Val Leu Thr  Lys Phe Glu 
    1070                 1075                 1080             


Ile Phe  Tyr Asn Ile Ser Asn  Gln Ser Ile Thr Asn  Lys Thr Cys 
    1085                 1090                 1095             


Glu Asp  Trp Ile Ala Val Asn  Val Thr Pro Ser Val  Met Ser Phe 
    1100                 1105                 1110             


Gln Leu  Glu Gly Met Ser Pro  Arg Cys Phe Ile Ala  Phe Gln Val 
    1115                 1120                 1125             


Arg Ala  Phe Thr Ser Lys Gly  Pro Gly Pro Tyr Ala  Asp Val Val 
    1130                 1135                 1140             


Lys Ser  Thr Thr Ser Glu Ile  Asn Pro Phe Pro His  Leu Ile Thr 
    1145                 1150                 1155             


Leu Leu  Gly Asn Lys Ile Val  Phe Leu Asp Met Asp  Gln Asn Gln 
    1160                 1165                 1170             


Val Val  Trp Thr Phe Ser Ala  Glu Arg Val Ile Ser  Ala Val Cys 
    1175                 1180                 1185             


Tyr Thr  Ala Asp Asn Glu Met  Gly Tyr Tyr Ala Glu  Gly Asp Ser 
    1190                 1195                 1200             


Leu Phe  Leu Leu His Leu His  Asn Arg Ser Ser Ser  Glu Leu Phe 
    1205                 1210                 1215             


Gln Asp  Ser Leu Val Phe Asp  Ile Thr Val Ile Thr  Ile Asp Trp 
    1220                 1225                 1230             


Ile Ser  Arg His Leu Tyr Phe  Ala Leu Lys Glu Ser  Gln Asn Gly 
    1235                 1240                 1245             


Met Gln  Val Phe Asp Val Asp  Leu Glu His Lys Val  Lys Tyr Pro 
    1250                 1255                 1260             


Arg Glu  Val Lys Ile His Asn  Arg Asn Ser Thr Ile  Ile Ser Phe 
    1265                 1270                 1275             


Ser Val  Tyr Pro Leu Leu Ser  Arg Leu Tyr Trp Thr  Glu Val Ser 
    1280                 1285                 1290             


Asn Phe  Gly Tyr Gln Met Phe  Tyr Tyr Ser Ile Ile  Ser His Thr 
    1295                 1300                 1305             


Leu His  Arg Ile Leu Gln Pro  Thr Ala Thr Asn Gln  Gln Asn Lys 
    1310                 1315                 1320             


Arg Asn  Gln Cys Ser Cys Asn  Val Thr Glu Phe Glu  Leu Ser Gly 
    1325                 1330                 1335             


Ala Met  Ala Ile Asp Thr Ser  Asn Leu Glu Lys Pro  Leu Ile Tyr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Gln Glu Ile  Trp Ala Met Asp Leu  Glu Gly Cys 
    1355                 1360                 1365             


Gln Cys  Trp Arg Val Ile Thr  Val Pro Ala Met Leu  Ala Gly Lys 
    1370                 1375                 1380             


Thr Leu  Val Ser Leu Thr Val  Asp Gly Asp Leu Ile  Tyr Trp Ile 
    1385                 1390                 1395             


Ile Thr  Ala Lys Asp Ser Thr  Gln Ile Tyr Gln Ala  Lys Lys Gly 
    1400                 1405                 1410             


Asn Gly  Ala Ile Val Ser Gln  Val Lys Ala Leu Arg  Ser Arg His 
    1415                 1420                 1425             


Ile Leu  Ala Tyr Ser Ser Val  Met Gln Pro Phe Pro  Asp Lys Ala 
    1430                 1435                 1440             


Phe Leu  Ser Leu Ala Ser Asp  Thr Val Glu Pro Thr  Ile Leu Asn 
    1445                 1450                 1455             


Ala Thr  Asn Thr Ser Leu Thr  Ile Arg Leu Pro Leu  Ala Lys Thr 
    1460                 1465                 1470             


Asn Leu  Thr Trp Tyr Gly Ile  Thr Ser Pro Thr Pro  Thr Tyr Leu 
    1475                 1480                 1485             


Val Tyr  Tyr Ala Glu Val Asn  Asp Arg Lys Asn Ser  Ser Asp Leu 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Leu Glu Phe  Gln Asp Ser Ile Ala  Leu Ile Glu 
    1505                 1510                 1515             


Asp Leu  Gln Pro Phe Ser Thr  Tyr Met Ile Gln Ile  Ala Val Lys 
    1520                 1525                 1530             


Asn Tyr  Tyr Ser Asp Pro Leu  Glu His Leu Pro Pro  Gly Lys Glu 
    1535                 1540                 1545             


Ile Trp  Gly Lys Thr Lys Asn  Gly Val Pro Glu Ala  Val Gln Leu 
    1550                 1555                 1560             


Ile Asn  Thr Thr Val Arg Ser  Asp Thr Ser Leu Ile  Ile Ser Trp 
    1565                 1570                 1575             


Arg Glu  Ser His Lys Pro Asn  Gly Pro Lys Glu Ser  Val Arg Tyr 
    1580                 1585                 1590             


Gln Leu  Ala Ile Ser His Leu  Ala Leu Ile Pro Glu  Thr Pro Leu 
    1595                 1600                 1605             


Arg Gln  Ser Glu Phe Pro Asn  Gly Arg Leu Thr Leu  Leu Val Thr 
    1610                 1615                 1620             


Arg Leu  Ser Gly Gly Asn Ile  Tyr Val Leu Lys Val  Leu Ala Cys 
    1625                 1630                 1635             


His Ser  Glu Glu Met Trp Cys  Thr Glu Ser His Pro  Val Thr Val 
    1640                 1645                 1650             


Glu Met  Phe Asn Thr Pro Glu  Lys Pro Tyr Ser Leu  Val Pro Glu 
    1655                 1660                 1665             


Asn Thr  Ser Leu Gln Phe Asn  Trp Lys Ala Pro Leu  Asn Val Asn 
    1670                 1675                 1680             


Leu Ile  Arg Phe Trp Val Glu  Leu Gln Lys Trp Lys  Tyr Asn Glu 
    1685                 1690                 1695             


Phe Tyr  His Val Lys Thr Ser  Cys Ser Gln Gly Pro  Ala Tyr Val 
    1700                 1705                 1710             


Cys Asn  Ile Thr Asn Leu Gln  Pro Tyr Thr Ser Tyr  Asn Val Arg 
    1715                 1720                 1725             


Val Val  Val Val Tyr Lys Thr  Gly Glu Asn Ser Thr  Ser Leu Pro 
    1730                 1735                 1740             


Glu Ser  Phe Lys Thr Lys Ala  Gly Val Pro Asn Lys  Pro Gly Ile 
    1745                 1750                 1755             


Pro Lys  Leu Leu Glu Gly Ser  Lys Asn Ser Ile Gln  Trp Glu Lys 
    1760                 1765                 1770             


Ala Glu  Asp Asn Gly Cys Arg  Ile Thr Tyr Tyr Ile  Leu Glu Ile 
    1775                 1780                 1785             


Arg Lys  Ser Thr Ser Asn Asn  Leu Gln Asn Gln Asn  Leu Arg Trp 
    1790                 1795                 1800             


Lys Met  Thr Phe Asn Gly Ser  Cys Ser Ser Val Cys  Thr Trp Lys 
    1805                 1810                 1815             


Ser Lys  Asn Leu Lys Gly Ile  Phe Gln Phe Arg Val  Val Ala Ala 
    1820                 1825                 1830             


Asn Asn  Leu Gly Phe Gly Glu  Tyr Ser Gly Ile Ser  Glu Asn Ile 
    1835                 1840                 1845             


Ile Leu  Val Gly Asp Asp Phe  Trp Ile Pro Glu Thr  Ser Phe Ile 
    1850                 1855                 1860             


Leu Thr  Ile Ile Val Gly Ile  Phe Leu Val Val Thr  Ile Pro Leu 
    1865                 1870                 1875             


Thr Phe  Val Trp His Arg Arg  Leu Lys Asn Gln Lys  Ser Ala Lys 
    1880                 1885                 1890             


Glu Gly  Val Thr Val Leu Ile  Asn Glu Asp Lys Glu  Leu Ala Glu 
    1895                 1900                 1905             


Leu Arg  Gly Leu Ala Ala Gly  Val Gly Leu Ala Asn  Ala Cys Tyr 
    1910                 1915                 1920             


Ala Ile  His Thr Leu Pro Thr  Gln Glu Glu Ile Glu  Asn Leu Pro 
    1925                 1930                 1935             


Ala Phe  Pro Arg Glu Lys Leu  Thr Leu Arg Leu Leu  Leu Gly Ser 
    1940                 1945                 1950             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Thr Ala Val  Asp Ile Leu 
    1955                 1960                 1965             


Gly Val  Gly Ser Gly Glu Ile  Lys Val Ala Val Lys  Thr Leu Lys 
    1970                 1975                 1980             


Lys Gly  Ser Thr Asp Gln Glu  Lys Ile Glu Phe Leu  Lys Glu Ala 
    1985                 1990                 1995             


His Leu  Met Ser Lys Phe Asn  His Pro Asn Ile Leu  Lys Gln Leu 
    2000                 2005                 2010             


Gly Val  Cys Leu Leu Asn Glu  Pro Gln Tyr Ile Ile  Leu Glu Leu 
    2015                 2020                 2025             


Met Glu  Gly Gly Asp Leu Leu  Thr Tyr Leu Arg Lys  Ala Arg Met 
    2030                 2035                 2040             


Ala Thr  Phe Tyr Gly Pro Leu  Leu Thr Leu Val Asp  Leu Val Asp 
    2045                 2050                 2055             


Leu Cys  Val Asp Ile Ser Lys  Gly Cys Val Tyr Leu  Glu Arg Met 
    2060                 2065                 2070             


His Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Ser 
    2075                 2080                 2085             


Val Lys  Asp Tyr Thr Ser Pro  Arg Ile Val Lys Ile  Gly Asp Phe 
    2090                 2095                 2100             


Gly Leu  Ala Arg Asp Ile Tyr  Lys Asn Asp Tyr Tyr  Arg Lys Arg 
    2105                 2110                 2115             


Gly Glu  Gly Leu Leu Pro Val  Arg Trp Met Ala Pro  Glu Ser Leu 
    2120                 2125                 2130             


Met Asp  Gly Ile Phe Thr Thr  Gln Ser Asp Val Trp  Ser Phe Gly 
    2135                 2140                 2145             


Ile Leu  Ile Trp Glu Ile Leu  Thr Leu Gly His Gln  Pro Tyr Pro 
    2150                 2155                 2160             


Ala His  Ser Asn Leu Asp Val  Leu Asn Tyr Val Gln  Thr Gly Gly 
    2165                 2170                 2175             


Arg Leu  Glu Pro Pro Arg Asn  Cys Pro Asp Asp Leu  Trp Asn Leu 
    2180                 2185                 2190             


Met Thr  Gln Cys Trp Ala Gln  Glu Pro Asp Gln Arg  Pro Thr Phe 
    2195                 2200                 2205             


His Arg  Ile Gln Asp Gln Leu  Gln Leu Phe Arg Asn  Phe Phe Leu 
    2210                 2215                 2220             


Asn Ser  Ile Tyr Lys Ser Arg  Asp Glu Ala Asn Asn  Ser Gly Val 
    2225                 2230                 2235             


Ile Asn  Glu Ser Phe Glu Gly  Glu Asp Gly Asp Val  Ile Cys Leu 
    2240                 2245                 2250             


Asn Ser  Asp Asp Ile Met Pro  Val Ala Leu Met Glu  Thr Lys Asn 
    2255                 2260                 2265             


Arg Glu  Gly Leu Asn Tyr Met  Val Leu Ala Thr Glu  Cys Gly Gln 
    2270                 2275                 2280             


Gly Glu  Glu Lys Ser Glu Gly  Pro Leu Gly Ser Gln  Glu Ser Glu 
    2285                 2290                 2295             


Ser Cys  Gly Leu Arg Lys Glu  Glu Lys Glu Pro His  Ala Asp Lys 
    2300                 2305                 2310             


Asp Phe  Cys Gln Glu Lys Gln  Val Ala Tyr Cys Pro  Ser Gly Lys 
    2315                 2320                 2325             


Pro Glu  Gly Leu Asn Tyr Ala  Cys Leu Thr His Ser  Gly Tyr Gly 
    2330                 2335                 2340             


Asp Gly  Ser Asp 
    2345         


<210>  2
<211>  7368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  2
caagctttca agcattcaaa ggtctaaatg aaaaaggcta agtattattt caaaaggcaa       60

gtatatccta atatagcaaa acaaacaaag caaaatccat cagctactcc tccaattgaa      120

gtgatgaagc ccaaataatt catatagcaa aatggagaaa attagaccgg ccatctaaaa      180

atctgccatt ggtgaagtga tgaagaacat ttactgtctt attccgaagc ttgtcaattt      240

tgcaactctt ggctgcctat ggatttctgt ggtgcagtgt acagttttaa atagctgcct      300

aaagtcgtgt gtaactaatc tgggccagca gcttgacctt ggcacaccac ataatctgag      360

tgaaccgtgt atccaaggat gtcacttttg gaactctgta gatcagaaaa actgtgcttt      420

aaagtgtcgg gagtcgtgtg aggttggctg tagcagcgcg gaaggtgcat atgaagagga      480

agtactggaa aatgcagacc taccaactgc tccctttgct tcttccattg gaagccacaa      540

tatgacatta cgatggaaat ctgcaaactt ctctggagta aaatacatca ttcagtggaa      600

atatgcacaa cttctgggaa gctggactta tactaagact gtgtccagac cgtcctatgt      660

ggtcaagccc ctgcacccct tcactgagta cattttccga gtggtttgga tcttcacagc      720

gcagctgcag ctctactccc ctccaagtcc cagttacagg actcatcctc atggagttcc      780

tgaaactgca cctttgatta ggaatattga gagctcaagt cccgacactg tggaagtcag      840

ctgggatcca cctcaattcc caggtggacc tattttgggt tataacttaa ggctgatcag      900

caaaaatcaa aaattagatg cagggacaca gagaaccagt ttccagtttt actccacttt      960

accaaatact atctacaggt tttctattgc agcagtaaat gaagttggtg agggtccaga     1020

agcagaatct agtattacca cttcatcttc agcagttcaa caagaggaac agtggctctt     1080

tttatccaga aaaacttctc taagaaagag atctttaaaa catttagtag atgaagcaca     1140

ttgccttcgg ttggatgcta tataccataa tattacagga atatctgttg atgtccacca     1200

gcaaattgtt tatttctctg aaggaactct catatgggcg aagaaggctg ccaacatgtc     1260

tgatgtatct gacctgagaa ttttttacag aggttcagga ttaatttctt ctatctccat     1320

agattggctt tatcaaagaa tgtatttcat catggatgaa ctggtatgtg tctgtgattt     1380

agagaactgc tcaaacatcg aggaaattac tccaccctct attagtgcac ctcaaaaaat     1440

tgtggctgat tcatacaatg ggtatgtctt ttacctcctg agagatggca tttatagagc     1500

agaccttcct gtaccatctg gccggtgtgc agaagctgtg cgtattgtgg agagttgcac     1560

gttaaaggac tttgcaatca agccacaagc caagcgaatc atttacttca atgacactgc     1620

ccaagtcttc atgtcaacat ttctggatgg ctctgcttcc catctcatcc tacctcgcat     1680

cccctttgct gatgtgaaaa gttttgcttg tgaaaacaat gactttcttg tcacagatgg     1740

caaggtcatt ttccaacagg atgctttgtc ttttaatgaa ttcatcgtgg gatgtgacct     1800

gagtcacata gaagaatttg ggtttggtaa cttggtcatc tttggctcat cctcccagct     1860

gcaccctctg ccaggccgcc cgcaggagct ttcggtgctg tttggctctc accaggctct     1920

tgttcaatgg aagcctcctg cccttgccat aggagccaat gtcatcctga tcagtgatat     1980

tattgaactc tttgaattag gcccttctgc ctggcagaac tggacctatg aggtgaaagt     2040

atccacccaa gaccctcctg aagtcactca tattttcttg aacataagtg gaaccatgct     2100

gaatgtacct gagctgcaga gtgctatgaa atacaaggtt tctgtgagag caagttctcc     2160

aaagaggcca ggcccctggt cagagccctc agtgggtact accctggtgc cagctagtga     2220

accaccattt atcatggctg tgaaagaaga tgggctttgg agtaaaccat taaatagctt     2280

tggcccagga gagttcttat cctctgatat aggaaatgtg tcagacatgg attggtataa     2340

caacagcctc tactacagtg acacgaaagg cgacgttttt gtgtggctgc tgaatgggac     2400

ggatatctca gagaattatc acctacccag cattgcagga gcaggggctt tagcttttga     2460

gtggctgggt cactttctct actgggctgg aaagacatat gtgatacaaa ggcagtctgt     2520

gttgacggga cacacagaca ttgttaccca cgtgaagcta ttggtgaatg acatggtggt     2580

ggattcagtt ggtggatatc tctactggac cacactctat tcagtggaaa gcaccagact     2640

aaatggggaa agttcccttg tactacagac acagccttgg ttttctggga aaaaggtaat     2700

tgctctaact ttagacctca gtgatgggct cctgtattgg ttggttcaag acagtcaatg     2760

tattcacctg tacacagctg ttcttcgggg acagagcact ggggatacca ccatcacaga     2820

atttgcagcc tggagtactt ctgaaatttc ccagaatgca ctgatgtact atagtggtcg     2880

gctgttctgg atcaatggct ttaggattat cacaactcaa gaaataggtc agaaaaccag     2940

tgtctctgtt ttggaaccag ccagatttaa tcagttcaca attattcaga catcccttaa     3000

gcccctgcca gggaactttt cctttacccc taaggttatt ccagattctg ttcaagagtc     3060

ttcatttagg attgaaggaa atgcttcaag ttttcaaatc ctgtggaatg gtccccctgc     3120

ggtagactgg ggtgtagttt tctacagtgt agaatttagt gctcattcta agttcttggc     3180

tagtgaacaa cactctttac ctgtatttac tgtggaagga ctggaacctt atgccttatt     3240

taatctttct gtcactcctt atacctactg gggaaagggc cccaaaacat ctctgtcact     3300

tcgagcacct gaaacagttc catcagcacc agagaacccc agaatattta tattaccaag     3360

tggaaaatgc tgcaacaaga atgaagttgt ggtggaattt aggtggaaca aacctaagca     3420

tgaaaatggg gtgttaacaa aatttgaaat tttctacaat atatccaatc aaagtattac     3480

aaacaaaaca tgtgaagact ggattgctgt caatgtcact ccctcagtga tgtcttttca     3540

acttgaaggc atgagtccca gatgctttat tgccttccag gttagggcct ttacatctaa     3600

ggggccagga ccatatgctg acgttgtaaa gtctacaaca tcagaaatca acccatttcc     3660

tcacctcata actcttcttg gtaacaagat agttttttta gatatggatc aaaatcaagt     3720

tgtgtggacg ttttcagcag aaagagttat cagtgccgtt tgctacacag ctgataatga     3780

gatgggatat tatgctgaag gggactcact ctttcttctg cacttgcaca atcgctctag     3840

ctctgagctt ttccaagatt cactggtttt tgatatcaca gttattacaa ttgactggat     3900

ttcaaggcac ctctactttg cactgaaaga atcacaaaat ggaatgcaag tatttgatgt     3960

tgatcttgaa cacaaggtga aatatcccag agaggtgaag attcacaata ggaattcaac     4020

aataatttct ttttctgtat atcctctttt aagtcgcttg tattggacag aagtttccaa     4080

ttttggctac cagatgttct actacagtat tatcagtcac accttgcacc gaattctgca     4140

acccacagct acaaaccaac aaaacaaaag gaatcaatgt tcttgtaatg tgactgaatt     4200

tgagttaagt ggagcaatgg ctattgatac ctctaaccta gagaaaccat tgatatactt     4260

tgccaaagca caagagatct gggcaatgga tctggaaggc tgtcagtgtt ggagagttat     4320

cacagtacct gctatgctcg caggaaaaac ccttgttagc ttaactgtgg atggagatct     4380

tatatactgg atcatcacag caaaggacag cacacagatt tatcaggcaa agaaaggaaa     4440

tggggccatc gtttcccagg tgaaggccct aaggagtagg catatcttgg cttacagttc     4500

agttatgcag ccttttccag ataaagcgtt tctgtctcta gcttcagaca ctgtggaacc     4560

aactatactt aatgccacta acactagcct cacaatcaga ttacctctgg ccaagacaaa     4620

cctcacatgg tatggcatca ccagccctac tccaacatac ctggtttatt atgcagaagt     4680

taatgacagg aaaaacagct ctgacttgaa atatagaatt ctggaatttc aggacagtat     4740

agctcttatt gaagatttac aaccattttc aacatacatg atacagatag ctgtaaaaaa     4800

ttattattca gatcctttgg aacatttacc accaggaaaa gagatttggg gaaaaactaa     4860

aaatggagta ccagaggcag tgcagctcat taatacaact gtgcggtcag acaccagcct     4920

cattatatct tggagagaat ctcacaagcc aaatggacct aaagaatcag tccgttatca     4980

gttggcaatc tcacacctgg ccctaattcc tgaaactcct ctaagacaaa gtgaatttcc     5040

aaatggaagg ctcactctcc ttgttactag actgtctggt ggaaatattt atgtgttaaa     5100

ggttcttgcc tgccactctg aggaaatgtg gtgtacagag agtcatcctg tcactgtgga     5160

aatgtttaac acaccagaga aaccttattc cttggttcca gagaacacta gtttgcaatt     5220

taattggaag gctccattga atgttaacct catcagattt tgggttgagc tacagaagtg     5280

gaaatacaat gagttttacc atgttaaaac ttcatgcagc caaggtcctg cttatgtctg     5340

taatatcaca aatctacaac cttatacttc atataatgtc agagtagtgg tggtttataa     5400

gacgggagaa aatagcacct cacttccaga aagctttaag acaaaagctg gagtcccaaa     5460

taaaccaggc attcccaaat tactagaagg gagtaaaaat tcaatacagt gggagaaagc     5520

tgaagataat ggatgtagaa ttacatacta tatccttgag ataagaaaga gcacttcaaa     5580

taatttacag aaccagaatt taaggtggaa gatgacattt aatggatcct gcagtagtgt     5640

ttgcacatgg aagtccaaaa acctgaaagg aatatttcag ttcagagtag tagctgcaaa     5700

taatctaggg tttggtgaat atagtggaat cagtgagaat attatattag ttggagatga     5760

tttttggata ccagaaacaa gtttcatact tactattata gttggaatat ttctggttgt     5820

tacaatccca ctgacctttg tctggcatag aagattaaag aatcaaaaaa gtgccaagga     5880

aggggtgaca gtgcttataa acgaagacaa agagttggct gagctgcgag gtctggcagc     5940

cggagtaggc ctggctaatg cctgctatgc aatacatact cttccaaccc aagaggagat     6000

tgaaaatctt cctgccttcc ctcgggaaaa actgactctg cgtctcttgc tgggaagtgg     6060

agcctttgga gaagtgtatg aaggaacagc agtggacatc ttaggagttg gaagtggaga     6120

aatcaaagta gcagtgaaga ctttgaagaa gggttccaca gaccaggaga agattgaatt     6180

cctgaaggag gcacatctga tgagcaaatt taatcatccc aacattctga agcagcttgg     6240

agtttgtctg ctgaatgaac cccaatacat tatcctggaa ctgatggagg gaggagacct     6300

tcttacttat ttgcgtaaag cccggatggc aacgttttat ggtcctttac tcaccttggt     6360

tgaccttgta gacctgtgtg tagatatttc aaaaggctgt gtctacttgg aacggatgca     6420

tttcattcac agggatctgg cagctagaaa ttgccttgtt tccgtgaaag actataccag     6480

tccacggata gtgaagattg gagactttgg actcgccaga gacatctata aaaatgatta     6540

ctatagaaag agaggggaag gcctgctccc agttcggtgg atggctccag aaagtttgat     6600

ggatggaatc ttcactactc aatctgatgt atggtctttt ggaattctga tttgggagat     6660

tttaactctt ggtcatcagc cttatccagc tcattccaac cttgatgtgt taaactatgt     6720

gcaaacagga gggagactgg agccaccaag aaattgtcct gatgatctgt ggaatttaat     6780

gacccagtgc tgggctcaag aacccgacca aagacctact tttcatagaa ttcaggacca     6840

acttcagtta ttcagaaatt ttttcttaaa tagcatttat aagtccagag atgaagcaaa     6900

caacagtgga gtcataaatg aaagctttga aggtgaagat ggcgatgtga tttgtttgaa     6960

ttcagatgac attatgccag ttgctttaat ggaaacgaag aaccgagaag ggttaaacta     7020

tatggtactt gctacagaat gtggccaagg tgaagaaaag tctgagggtc ctctaggctc     7080

ccaggaatct gaatcttgtg gtctgaggaa agaagagaag gaaccacatg cagacaaaga     7140

tttctgccaa gaaaaacaag tggcttactg cccttctggc aagcctgaag gcctgaacta     7200

tgcctgtctc actcacagtg gatatggaga tgggtctgat taatagcgtt gtttgggaaa     7260

tagagagttg agataaacac tctcattcag tagttactga aagaaaactc tgctagaatg     7320

ataaatgtca tggtggtcta taactccaaa taaacaatgc aacgttcc                  7368


<210>  3
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys 
        115                 120                 125             


Met Ala Gly Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu 
    130                 135                 140                 


Leu Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser 
145                 150                 155                 160 


Ser Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser Ser Leu Leu 
                165                 170                 175     


Thr Val Arg Ala Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr 
            180                 185                 190         


Ser Ile Thr Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser 
        195                 200                 205             


Glu Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn 
    210                 215                 220                 


Trp Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr 
225                 230                 235                 240 


Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn 
                245                 250                 255     


Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr 
            260                 265                 270         


Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala Met 
        275                 280                 285             


Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile Trp Cys Lys 
    290                 295                 300                 


Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr Val Pro Ser Thr Ala 
305                 310                 315                 320 


Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr Asp Gly Ile Gln Asn Trp 
                325                 330                 335     


Thr Met Lys Asn Val Thr Tyr Lys Glu Asn Ile Ala Lys Cys Gln His 
            340                 345                 350         


Ile Phe Val Asn Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu 
        355                 360                 365             


Leu Ile Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val 
    370                 375                 380                 


Lys Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys 
385                 390                 395                 400 


Lys Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly 
                405                 410                 415     


Tyr Leu Ala Ile Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser 
            420                 425                 430         


Ser Ser Val Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val 
        435                 440                 445             


Ile Thr Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly 
    450                 455                 460                 


Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala 
465                 470                 475                 480 


Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile 
                485                 490                 495     


Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile 
            500                 505                 510         


Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp Phe 
        515                 520                 525             


Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro Leu Thr Val 
    530                 535                 540                 


Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu Val Gly Val Gly Val 
545                 550                 555                 560 


Pro Val Val Phe Ile Ile Ile Leu Val Leu Cys Leu Arg Leu Leu Gln 
                565                 570                 575     


Ser Arg Cys Pro Arg Val Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe 
            580                 585                 590         


Leu Pro Leu Trp Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser 
        595                 600                 605             


Lys Phe Thr Gly Cys Phe Gln Met Arg Cys Cys Tyr Cys Cys Arg Val 
    610                 615                 620                 


Cys Cys Arg Ala Cys Cys Leu Leu Cys Gly Cys Pro Lys Cys Cys Arg 
625                 630                 635                 640 


Cys Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp 
                645                 650                 655     


Val Pro Val Lys Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg 
            660                 665                 670         


Glu Ala Gln Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr 
        675                 680                 685             


Ala Leu 
    690 


<210>  4
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  4
cgggccaggt ttccaggctc ggccgccgcc tccatcccag cacctgcgga gggagcgctg       60

accatggctc cctggcctga attgggagat gcccagccca accccgataa gtacctcgaa      120

ggggccgcag gtcagcagcc cactgcccct gataaaagca aagagaccaa caaaacagat      180

aacactgagg cacctgtaac caagattgaa cttctgccgt cctactccac ggctacactg      240

atagatgagc ccactgaggt ggatgacccc tggaacctac ccactcttca ggactcgggg      300

atcaagtggt cagagagaga caccaaaggg aagattctct gtttcttcca agggattggg      360

agattgattt tacttctcgg atttctctac tttttcgtgt gctccctgga tattcttagt      420

agcgccttcc agctggttgg aggaaaaatg gcaggacagt tcttcagcaa cagctctatt      480

atgtccaacc ctttgttggg gctggtgatc ggggtgctgg tgaccgtctt ggtgcagagc      540

tccagcacct caacgtccat cgttgtcagc atggtgtcct cttcattgct cactgttcgg      600

gctgccatcc ccattatcat gggggccaac attggaacgt caatcaccaa cactattgtt      660

gcgctcatgc aggtgggaga tcggagtgag ttcagaagag cttttgcagg agccactgtc      720

catgacttct tcaactggct gtccgtgttg gtgctcttgc ccgtggaggt ggccacccat      780

tacctcgaga tcataaccca gcttatagtg gagagcttcc acttcaagaa tggagaagat      840

gccccagatc ttctgaaagt catcactaag cccttcacaa agctcattgt ccagctggat      900

aaaaaagtta tcagccaaat tgcaatgaac gatgaaaaag cgaaaaacaa gagtcttgtc      960

aagatttggt gcaaaacttt taccaacaag acccagatta acgtcactgt tccctcgact     1020

gctaactgca cctccccttc cctctgttgg acggatggca tccaaaactg gaccatgaag     1080

aatgtgacct acaaggagaa catcgccaaa tgccagcata tctttgtgaa tttccacctc     1140

ccggatcttg ctgtgggcac catcttgctc atactctccc tgctggtcct ctgtggttgc     1200

ctgatcatga ttgtcaagat cctgggctct gtgctcaagg ggcaggtcgc cactgtcatc     1260

aagaagacca tcaacactga tttccccttt ccctttgcat ggttgactgg ctacctggcc     1320

atcctcgtcg gggcaggcat gaccttcatc gtacagagca gctctgtgtt cacgtcggcc     1380

ttgacccccc tgattggaat cggcgtgata accattgaga gggcttatcc actcacgctg     1440

ggctccaaca tcggcaccac caccaccgcc atcctggccg ccttagccag ccctggcaat     1500

gcattgagga gttcactcca gatcgccctg tgccactttt tcttcaacat ctccggcatc     1560

ttgctgtggt acccgatccc gttcactcgc ctgcccatcc gcatggccaa ggggctgggc     1620

aacatctctg ccaagtatcg ctggttcgcc gtcttctacc tgatcatctt cttcttcctg     1680

atcccgctga cggtgtttgg cctctcgctg gccggctggc gggtgctggt tggtgtcggg     1740

gttcccgtcg tcttcatcat catcctggta ctgtgcctcc gactcctgca gtctcgctgc     1800

ccacgcgtcc tgccgaagaa actccagaac tggaacttcc tgccgctgtg gatgcgctcg     1860

ctgaagccct gggatgccgt cgtctccaag ttcaccggct gcttccagat gcgctgctgc     1920

tactgctgcc gcgtgtgctg ccgcgcgtgc tgcttgctgt gtggctgccc caagtgctgc     1980

cgctgcagca agtgctgcga ggacttggag gaggcgcagg aggggcagga tgtccctgtc     2040

aaggctcctg agacctttga taacataacc attagcagag aggctcaggg tgaggtccct     2100

gcctcggact caaagaccga atgcacggcc ttgtagggga cgccccagat tgtcagggat     2160

ggggggatgg tccttgagtt ttgcatgctc tcctccctcc cacttctgca ccctttcacc     2220

acctcgagga gatttgctcc ccattagcga atgaaattga tgcagtccta aaaaaaaaaa     2280


<210>  5
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Ala Gly 
        115                 120                 125             


Val Pro Asn Lys Pro Gly Ile Pro Lys Leu Leu Glu Gly Ser Lys Asn 
    130                 135                 140                 


Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn Gly Cys Arg Ile Thr Tyr 
145                 150                 155                 160 


Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser Asn Asn Leu Gln Asn Gln 
                165                 170                 175     


Asn Leu Arg Trp Lys Met Thr Phe Asn Gly Ser Cys Ser Ser Val Cys 
            180                 185                 190         


Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile Phe Gln Phe Arg Val Val 
        195                 200                 205             


Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr Ser Gly Ile Ser Glu Asn 
    210                 215                 220                 


Ile Ile Leu Val Gly Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile 
225                 230                 235                 240 


Leu Thr Ile Ile Val Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr 
                245                 250                 255     


Phe Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly 
            260                 265                 270         


Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly 
        275                 280                 285             


Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr 
    290                 295                 300                 


Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu 
305                 310                 315                 320 


Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val 
                325                 330                 335     


Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile 
            340                 345                 350         


Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys 
        355                 360                 365             


Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro 
    370                 375                 380                 


Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr 
385                 390                 395                 400 


Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg 
                405                 410                 415     


Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp 
            420                 425                 430         


Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu 
        435                 440                 445             


Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    450                 455                 460                 


Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe 
465                 470                 475                 480 


Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly 
                485                 490                 495     


Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp 
            500                 505                 510         


Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile 
        515                 520                 525             


Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn 
    530                 535                 540                 


Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro 
545                 550                 555                 560 


Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala 
                565                 570                 575     


Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu 
            580                 585                 590         


Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp 
        595                 600                 605             


Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp 
    610                 615                 620                 


Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu 
625                 630                 635                 640 


Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr 
                645                 650                 655     


Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln 
            660                 665                 670         


Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala 
        675                 680                 685             


Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly 
    690                 695                 700                 


Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly 
705                 710                 715                 720 


Asp Gly Ser Asp 
                


<210>  6
<211>  2175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  6
atggctccct ggcctgaatt gggagatgcc cagcccaacc ccgataagta cctcgaaggg       60

gccgcaggtc agcagcccac tgcccctgat aaaagcaaag agaccaacaa aacagataac      120

actgaggcac ctgtaaccaa gattgaactt ctgccgtcct actccacggc tacactgata      180

gatgagccca ctgaggtgga tgacccctgg aacctaccca ctcttcagga ctcggggatc      240

aagtggtcag agagagacac caaagggaag attctctgtt tcttccaagg gattgggaga      300

ttgattttac ttctcggatt tctctacttt ttcgtgtgct ccctggatat tcttagtagc      360

gccttccagc tggttggagc tggagtccca aataaaccag gcattcccaa attactagaa      420

gggagtaaaa attcaataca gtgggagaaa gctgaagata atggatgtag aattacatac      480

tatatccttg agataagaaa gagcacttca aataatttac agaaccagaa tttaaggtgg      540

aagatgacat ttaatggatc ctgcagtagt gtttgcacat ggaagtccaa aaacctgaaa      600

ggaatatttc agttcagagt agtagctgca aataatctag ggtttggtga atatagtgga      660

atcagtgaga atattatatt agttggagat gatttttgga taccagaaac aagtttcata      720

cttactatta tagttggaat atttctggtt gttacaatcc cactgacctt tgtctggcat      780

agaagattaa agaatcaaaa aagtgccaag gaaggggtga cagtgcttat aaacgaagac      840

aaagagttgg ctgagctgcg aggtctggca gccggagtag gcctggctaa tgcctgctat      900

gcaatacata ctcttccaac ccaagaggag attgaaaatc ttcctgcctt ccctcgggaa      960

aaactgactc tgcgtctctt gctgggaagt ggagcctttg gagaagtgta tgaaggaaca     1020

gcagtggaca tcttaggagt tggaagtgga gaaatcaaag tagcagtgaa gactttgaag     1080

aagggttcca cagaccagga gaagattgaa ttcctgaagg aggcacatct gatgagcaaa     1140

tttaatcatc ccaacattct gaagcagctt ggagtttgtc tgctgaatga accccaatac     1200

attatcctgg aactgatgga gggaggagac cttcttactt atttgcgtaa agcccggatg     1260

gcaacgtttt atggtccttt actcaccttg gttgaccttg tagacctgtg tgtagatatt     1320

tcaaaaggct gtgtctactt ggaacggatg catttcattc acagggatct ggcagctaga     1380

aattgccttg tttccgtgaa agactatacc agtccacgga tagtgaagat tggagacttt     1440

ggactcgcca gagacatcta taaaaatgat tactatagaa agagagggga aggcctgctc     1500

ccagttcggt ggatggctcc agaaagtttg atggatggaa tcttcactac tcaatctgat     1560

gtatggtctt ttggaattct gatttgggag attttaactc ttggtcatca gccttatcca     1620

gctcattcca accttgatgt gttaaactat gtgcaaacag gagggagact ggagccacca     1680

agaaattgtc ctgatgatct gtggaattta atgacccagt gctgggctca agaacccgac     1740

caaagaccta cttttcatag aattcaggac caacttcagt tattcagaaa ttttttctta     1800

aatagcattt ataagtccag agatgaagca aacaacagtg gagtcataaa tgaaagcttt     1860

gaaggtgaag atggcgatgt gatttgtttg aattcagatg acattatgcc agttgcttta     1920

atggaaacga agaaccgaga agggttaaac tatatggtac ttgctacaga atgtggccaa     1980

ggtgaagaaa agtctgaggg tcctctaggc tcccaggaat ctgaatcttg tggtctgagg     2040

aaagaagaga aggaaccaca tgcagacaaa gatttctgcc aagaaaaaca agtggcttac     2100

tgcccttctg gcaagcctga aggcctgaac tatgcctgtc tcactcacag tggatatgga     2160

gatgggtctg attaa                                                      2175


<210>  7
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Asp Asp 
        115                 120                 125             


Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu Thr Ile Ile Val Gly Ile 
    130                 135                 140                 


Phe Leu Val Val Thr Ile Pro Leu Thr Phe Val Trp His Arg Arg Leu 
145                 150                 155                 160 


Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile Asn Glu 
                165                 170                 175     


Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val Gly Leu 
            180                 185                 190         


Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu Glu Ile 
        195                 200                 205             


Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu 
    210                 215                 220                 


Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp 
225                 230                 235                 240 


Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu 
                245                 250                 255     


Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala 
            260                 265                 270         


His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly 
        275                 280                 285             


Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu 
    290                 295                 300                 


Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe 
305                 310                 315                 320 


Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp 
                325                 330                 335     


Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile His Arg 
            340                 345                 350         


Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr Thr Ser 
        355                 360                 365             


Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Tyr 
    370                 375                 380                 


Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro Val Arg 
385                 390                 395                 400 


Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr Gln Ser 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu Gly 
            420                 425                 430         


His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn Tyr Val 
        435                 440                 445             


Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp Leu 
    450                 455                 460                 


Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg Pro 
465                 470                 475                 480 


Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn Phe Phe 
                485                 490                 495     


Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser Gly Val 
            500                 505                 510         


Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys Leu Asn 
        515                 520                 525             


Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn Arg Glu 
    530                 535                 540                 


Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu Glu 
545                 550                 555                 560 


Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly Leu 
                565                 570                 575     


Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys Gln Glu 
            580                 585                 590         


Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn Tyr 
        595                 600                 605             


Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
    610                 615                 620     


<210>  8
<211>  1866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  8
atggctccct ggcctgaatt gggagatgcc cagcccaacc ccgataagta cctcgaaggg       60

gccgcaggtc agcagcccac tgcccctgat aaaagcaaag agaccaacaa aacagataac      120

actgaggcac ctgtaaccaa gattgaactt ctgccgtcct actccacggc tacactgata      180

gatgagccca ctgaggtgga tgacccctgg aacctaccca ctcttcagga ctcggggatc      240

aagtggtcag agagagacac caaagggaag attctctgtt tcttccaagg gattgggaga      300

ttgattttac ttctcggatt tctctacttt ttcgtgtgct ccctggatat tcttagtagc      360

gccttccagc tggttggaga tgatttttgg ataccagaaa caagtttcat acttactatt      420

atagttggaa tatttctggt tgttacaatc ccactgacct ttgtctggca tagaagatta      480

aagaatcaaa aaagtgccaa ggaaggggtg acagtgctta taaacgaaga caaagagttg      540

gctgagctgc gaggtctggc agccggagta ggcctggcta atgcctgcta tgcaatacat      600

actcttccaa cccaagagga gattgaaaat cttcctgcct tccctcggga aaaactgact      660

ctgcgtctct tgctgggaag tggagccttt ggagaagtgt atgaaggaac agcagtggac      720

atcttaggag ttggaagtgg agaaatcaaa gtagcagtga agactttgaa gaagggttcc      780

acagaccagg agaagattga attcctgaag gaggcacatc tgatgagcaa atttaatcat      840

cccaacattc tgaagcagct tggagtttgt ctgctgaatg aaccccaata cattatcctg      900

gaactgatgg agggaggaga ccttcttact tatttgcgta aagcccggat ggcaacgttt      960

tatggtcctt tactcacctt ggttgacctt gtagacctgt gtgtagatat ttcaaaaggc     1020

tgtgtctact tggaacggat gcatttcatt cacagggatc tggcagctag aaattgcctt     1080

gtttccgtga aagactatac cagtccacgg atagtgaaga ttggagactt tggactcgcc     1140

agagacatct ataaaaatga ttactataga aagagagggg aaggcctgct cccagttcgg     1200

tggatggctc cagaaagttt gatggatgga atcttcacta ctcaatctga tgtatggtct     1260

tttggaattc tgatttggga gattttaact cttggtcatc agccttatcc agctcattcc     1320

aaccttgatg tgttaaacta tgtgcaaaca ggagggagac tggagccacc aagaaattgt     1380

cctgatgatc tgtggaattt aatgacccag tgctgggctc aagaacccga ccaaagacct     1440

acttttcata gaattcagga ccaacttcag ttattcagaa attttttctt aaatagcatt     1500

tataagtcca gagatgaagc aaacaacagt ggagtcataa atgaaagctt tgaaggtgaa     1560

gatggcgatg tgatttgttt gaattcagat gacattatgc cagttgcttt aatggaaacg     1620

aagaaccgag aagggttaaa ctatatggta cttgctacag aatgtggcca aggtgaagaa     1680

aagtctgagg gtcctctagg ctcccaggaa tctgaatctt gtggtctgag gaaagaagag     1740

aaggaaccac atgcagacaa agatttctgc caagaaaaac aagtggctta ctgcccttct     1800

ggcaagcctg aaggcctgaa ctatgcctgt ctcactcaca gtggatatgg agatgggtct     1860

gattaa                                                                1866


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  9
acccttctcg gttcttcgtt tcca                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  10
gcagctcagc caactctttg tctt                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  11
tgccagacaa aggtcagtgg gatt                                              24


<210>  12
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  12
attcttagta gcgccttcca gctggttgga gctggagtcc caaataaacc aggcattccc       60


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Ala Gly Val Pro Asn Lys 
1               5                   10                  15      


Pro Gly Ile Pro 
            20  


<210>  14
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  14
attcttagta gcgccttcca gctggttgga gatgattttt ggataccaga aacaagtttc       60


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Asp Asp Phe Trp Ile Pro 
1               5                   10                  15      


Glu Thr Ser Phe 
            20  


<210>  16
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  16
attcttagta gcgccttcca gctggttgga gtctggcata gaagattaaa gaatcaaaaa       60


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  17

Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Val Trp His Arg Arg Leu 
1               5                   10                  15      


Lys Asn Gln Lys 
            20  


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  18
tccatcccag cacctgcgga g                                                 21


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  19
catggctccc tggcctgaat tg                                                22


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  20
ctcaactctc tatttcccaa acaacgc                                           27


<210>  21
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  21
caacgctatt aatcagaccc atctcc                                            26


<210>  22
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  22

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu Thr Ile Ile Val 
    210                 215                 220                 


Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr Phe Val Trp His Arg 
225                 230                 235                 240 


Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile 
                245                 250                 255     


Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val 
            260                 265                 270         


Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu 
        275                 280                 285             


Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg 
    290                 295                 300                 


Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala 
305                 310                 315                 320 


Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys 
                325                 330                 335     


Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys 
            340                 345                 350         


Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln 
        355                 360                 365             


Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu 
    370                 375                 380                 


Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala 
385                 390                 395                 400 


Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys 
                405                 410                 415     


Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile 
            420                 425                 430         


His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr 
        435                 440                 445             


Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp 
    450                 455                 460                 


Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro 
465                 470                 475                 480 


Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr 
                485                 490                 495     


Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr 
            500                 505                 510         


Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn 
        515                 520                 525             


Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp 
    530                 535                 540                 


Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln 
545                 550                 555                 560 


Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn 
                565                 570                 575     


Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser 
            580                 585                 590         


Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys 
        595                 600                 605             


Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn 
    610                 615                 620                 


Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly 
625                 630                 635                 640 


Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys 
                645                 650                 655     


Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys 
            660                 665                 670         


Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu 
        675                 680                 685             


Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
    690                 695                 700             


<210>  23
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  23
atgcacagga ggagaagcag gagctgtcgg gaagatcaga agccagtcat ggatgaccag       60

cgcgacctta tctccaacaa tgagcaactg cccatgctgg gccggcgccc tggggccccg      120

gagagcaagt gcagccgcgg agccctgtac acaggctttt ccatcctggt gactctgctc      180

ctcgctggcc aggccaccac cgcctacttc ctgtaccagc agcagggccg gctggacaaa      240

ctgacagtca cctcccagaa cctgcagctg gagaacctgc gcatgaagct tcccaagcct      300

cccaagcctg tgagcaagat gcgcatggcc accccgctgc tgatgcaggc gctgcccatg      360

ggagccctgc cccaggggcc catgcagaat gccaccaagt atggcaacat gacagaggac      420

catgtgatgc acctgctcca gaatgctgac cccctgaagg tgtacccgcc actgaagggg      480

agcttcccgg agaacctgag acaccttaag aacaccatgg agaccataga ctggaaggtc      540

tttgagagct ggatgcacca ttggctcctg tttgaaatga gcaggcactc cttggagcaa      600

aagcccactg acgctccacc gaaagatgat ttttggatac cagaaacaag tttcatactt      660

actattatag ttggaatatt tctggttgtt acaatcccac tgacctttgt ctggcataga      720

agattaaaga atcaaaaaag tgccaaggaa ggggtgacag tgcttataaa cgaagacaaa      780

gagttggctg agctgcgagg tctggcagcc ggagtaggcc tggctaatgc ctgctatgca      840

atacatactc ttccaaccca agaggagatt gaaaatcttc ctgccttccc tcgggaaaaa      900

ctgactctgc gtctcttgct gggaagtgga gcctttggag aagtgtatga aggaacagca      960

gtggacatct taggagttgg aagtggagaa atcaaagtag cagtgaagac tttgaagaag     1020

ggttccacag accaggagaa gattgaattc ctgaaggagg cacatctgat gagcaaattt     1080

aatcatccca acattctgaa gcagcttgga gtttgtctgc tgaatgaacc ccaatacatt     1140

atcctggaac tgatggaggg aggagacctt cttacttatt tgcgtaaagc ccggatggca     1200

acgttttatg gtcctttact caccttggtt gaccttgtag acctgtgtgt agatatttca     1260

aaaggctgtg tctacttgga acggatgcat ttcattcaca gggatctggc agctagaaat     1320

tgccttgttt ccgtgaaaga ctataccagt ccacggatag tgaagattgg agactttgga     1380

ctcgccagag acatctataa aaatgattac tatagaaaga gaggggaagg cctgctccca     1440

gttcggtgga tggctccaga aagtttgatg gatggaatct tcactactca atctgatgta     1500

tggtcttttg gaattctgat ttgggagatt ttaactcttg gtcatcagcc ttatccagct     1560

cattccaacc ttgatgtgtt aaactatgtg caaacaggag ggagactgga gccaccaaga     1620

aattgtcctg atgatctgtg gaatttaatg acccagtgct gggctcaaga acccgaccaa     1680

agacctactt ttcatagaat tcaggaccaa cttcagttat tcagaaattt tttcttaaat     1740

agcatttata agtccagaga tgaagcaaac aacagtggag tcataaatga aagctttgaa     1800

ggtgaagatg gcgatgtgat ttgtttgaat tcagatgaca ttatgccagt tgctttaatg     1860

gaaacgaaga accgagaagg gttaaactat atggtacttg ctacagaatg tggccaaggt     1920

gaagaaaagt ctgagggtcc tctaggctcc caggaatctg aatcttgtgg tctgaggaaa     1980

gaagagaagg aaccacatgc agacaaagat ttctgccaag aaaaacaagt ggcttactgc     2040

ccttctggca agcctgaagg cctgaactat gcctgtctca ctcacagtgg atatggagat     2100

gggtctgatt aa                                                         2112


<210>  24
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  24

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Ala Pro Leu 
    290                 295     


<210>  25
<211>  899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  25
cagggtccca gatgcacagg aggagaagca ggagctgtcg ggaagatcag aagccagtca       60

tggatgacca gcgcgacctt atctccaaca atgagcaact gcccatgctg ggccggcgcc      120

ctggggcccc ggagagcaag tgcagccgcg gagccctgta cacaggcttt tccatcctgg      180

tgactctgct cctcgctggc caggccacca ccgcctactt cctgtaccag cagcagggcc      240

ggctggacaa actgacagtc acctcccaga acctgcagct ggagaacctg cgcatgaagc      300

ttcccaagcc tcccaagcct gtgagcaaga tgcgcatggc caccccgctg ctgatgcagg      360

cgctgcccat gggagccctg ccccaggggc ccatgcagaa tgccaccaag tatggcaaca      420

tgacagagga ccatgtgatg cacctgctcc agaatgctga ccccctgaag gtgtacccgc      480

cactgaaggg gagcttcccg gagaacctga gacaccttaa gaacaccatg gagaccatag      540

actggaaggt ctttgagagc tggatgcacc attggctcct gtttgaaatg agcaggcact      600

ccttggagca aaagcccact gacgctccac cgaaagtact gaccaagtgc caggaagagg      660

tcagccacat ccctgctgtc cacccgggtt cattcaggcc caagtgcgac gagaacggca      720

actatctgcc actccagtgc tatgggagca tcggctactg ctggtgtgtc ttccccaacg      780

gcacggaggt ccccaacacc agaagccgcg ggcaccataa ctgcagtgag tcactggaac      840

tggaggaccc gtcttctggg ctgggtgtga ccaagcagga tctgggccca gctcctttg       899


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  26
gcagaatgcc accaagtatg gcaa                                              24


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  27
tgccagacaa aggtcagtgg gatt                                              24


<210>  28
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  28

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Val Trp 
        115                 120                 125             


His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val 
    130                 135                 140                 


Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala 
145                 150                 155                 160 


Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr 
                165                 170                 175     


Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr 
            180                 185                 190         


Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly 
        195                 200                 205             


Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala 
    210                 215                 220                 


Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe 
225                 230                 235                 240 


Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu 
                245                 250                 255     


Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu 
            260                 265                 270         


Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg 
        275                 280                 285             


Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp 
    290                 295                 300                 


Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His 
305                 310                 315                 320 


Phe Ile His Arg Asp Leu Ala Ala Arg Cys Leu Val Ser Val Lys Asp 
                325                 330                 335     


Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala Arg 
            340                 345                 350         


Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu 
        355                 360                 365             


Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe Thr 
    370                 375                 380                 


Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu 
385                 390                 395                 400 


Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val Leu 
                405                 410                 415     


Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro 
            420                 425                 430         


Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro Asp 
        435                 440                 445             


Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg 
    450                 455                 460                 


Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn 
465                 470                 475                 480 


Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val Ile 
                485                 490                 495     


Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr Lys 
            500                 505                 510         


Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln 
        515                 520                 525             


Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser 
    530                 535                 540                 


Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp Phe 
545                 550                 555                 560 


Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly 
                565                 570                 575     


Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
            580                 585                 590         


<210>  29
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  29
atggctccct ggcctgaatt gggagatgcc cagcccaacc ccgataagta cctcgaaggg       60

gccgcaggtc agcagcccac tgcccctgat aaaagcaaag agaccaacaa aacagataac      120

actgaggcac ctgtaaccaa gattgaactt ctgccgtcct actccacggc tacactgata      180

gatgagccca ctgaggtgga tgacccctgg aacctaccca ctcttcagga ctcggggatc      240

aagtggtcag agagagacac caaagggaag attctctgtt tcttccaagg gattgggaga      300

ttgattttac ttctcggatt tctctacttt ttcgtgtgct ccctggatat tcttagtagc      360

gccttccagc tggttggagt ctggcataga agattaaaga atcaaaaaag tgccaaggaa      420

ggggtgacag tgcttataaa cgaagacaaa gagttggctg agctgcgagg tctggcagcc      480

ggagtaggcc tggctaatgc ctgctatgca atacatactc ttccaaccca agaggagatt      540

gaaaatcttc ctgccttccc tcgggaaaaa ctgactctgc gtctcttgct gggaagtgga      600

gcctttggag aagtgtatga aggaacagca gtggacatct taggagttgg aagtggagaa      660

atcaaagtag cagtgaagac tttgaagaag ggttccacag accaggagaa gattgaattc      720

ctgaaggagg cacatctgat gagcaaattt aatcatccca acattctgaa gcagcttgga      780

gtttgtctgc tgaatgaacc ccaatacatt atcctggaac tgatggaggg aggagacctt      840

cttacttatt tgcgtaaagc ccggatggca acgttttatg gtcctttact caccttggtt      900

gaccttgtag acctgtgtgt agatatttca aaaggctgtg tctacttgga acggatgcat      960

ttcattcaca gggatctggc agctagaaat tgccttgttt ccgtgaaaga ctataccagt     1020

ccacggatag tgaagattgg agactttgga ctcgccagag acatctataa aaatgattac     1080

tatagaaaga gaggggaagg cctgctccca gttcggtgga tggctccaga aagtttgatg     1140

gatggaatct tcactactca atctgatgta tggtcttttg gaattctgat ttgggagatt     1200

ttaactcttg gtcatcagcc ttatccagct cattccaacc ttgatgtgtt aaactatgtg     1260

caaacaggag ggagactgga gccaccaaga aattgtcctg atgatctgtg gaatttaatg     1320

acccagtgct gggctcaaga acccgaccaa agacctactt ttcatagaat tcaggaccaa     1380

cttcagttat tcagaaattt tttcttaaat agcatttata agtccagaga tgaagcaaac     1440

aacagtggag tcataaatga aagctttgaa ggtgaagatg gcgatgtgat ttgtttgaat     1500

tcagatgaca ttatgccagt tgctttaatg gaaacgaaga accgagaagg gttaaactat     1560

atggtacttg ctacagaatg tggccaaggt gaagaaaagt ctgagggtcc tctaggctcc     1620

caggaatctg aatcttgtgg tctgaggaaa gaagagaagg aaccacatgc agacaaagat     1680

ttctgccaag aaaaacaagt ggcttactgc ccttctggca agcctgaagg cctgaactat     1740

gcctgtctca ctcacagtgg atatggagat gggtctgatt aa                        1782


<210>  30
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  30

Phe Glu Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro 
1               5                   10                  15      


Pro Lys Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu Thr Ile 
            20                  25                  30          


Ile Val 
        


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  31
aagcccggag gcaacgtt                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  32
aagccgaagg ccgaactt                                                     18


<210>  33
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  33
gaagatctct gaccatggct ccctggcctg aa                                     32


<210>  34
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  34
gaagatctac gctattaatc agacccatct cc                                     32


<210>  35
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  35

Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His 
1               5                   10                  15      


Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg 
            20                  25                  30          


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  36

Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg 
1               5                   


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  37

Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu 
1               5                   10                  15      


Pro Val Arg 
            


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  38

Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu 
1               5                   10                  15      


Glu Lys 
        


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  39

Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln 
1               5                   10                  15      


Gly Glu Glu Lys 
            20  


<210>  40
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  40

Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu 
1               5                   10                  15      


Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly 
            20                  25                  30          


Leu Arg 
        


<210>  41
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  41

Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln 
1               5                   10                  15      


Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser 
            20                  25                  30          


Cys Gly Leu Arg 
        35      


<210>  42
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  42

Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala 
1               5                   10                  15      


Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
            20                  25              


<210>  43
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  43

Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr Asp Asp Gly 
1               5                   10                  15      


Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser Gly Arg 
            20                  25                  30      


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  44

Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys 
1               5                   10          


<210>  45
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  45

Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
1               5                   10                  15      


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
            20                  25                  30          


Val Pro Ser Gly Thr Ser Tyr Gly Lys 
        35                  40      


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  46

Gln Arg Pro Val Pro Gln Pro Ser Ser Ala Ser Leu Asp Glu Tyr Thr 
1               5                   10                  15      


Leu Met Arg 
            


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  47

Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met Thr 
1               5                   10                  15      


Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg 
            20                  25                  30  


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  48

Ser Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  49

Ala Ser Ser Pro Ala Glu Ser Ser Pro Glu Asp Ser Gly Tyr Met Arg 
1               5                   10                  15      


<210>  50
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  50

Ala Pro Tyr Thr Cys Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser 
1               5                   10                  15      


Ser Pro Val Gly Arg Ser Tyr Lys Ala Pro Tyr Thr Cys Gly Gly Asp 
            20                  25                  30          


Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
        35                  40                  45  


<210>  51
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  51

Ile Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro 
1               5                   10                  15      


Thr Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly 
            20                  25                  30          


Ile Lys 
        


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  52
cagcaagaga cgcagagtca gttt                                              24


<210>  53
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  53
gctgttctcc aggctgaagt atatgg                                            26


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  54
gtaaccctgg tgctagttgc aaag                                              24


<210>  55
<211>  2637
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  55
atgtcggcgg gcggtccatg cccagcagca gccggagggg gcccaggggg cgcctcctgc       60

tccgtggggg cccctggcgg ggtatccatg ttccggtggc tggaggtgct ggagaaggag      120

ttcgacaaag cttttgtgga tgtggatctg ctcctgggag agatcgatcc agaccaagcg      180

gacatcactt atgaggggcg acagaagatg accagcctga gctcctgctt tgcacagctt      240

tgccacaaag cccagtctgt gtctcaaatc aaccacaagc tggaggcaca gttggtggat      300

ctgaaatctg aactgacaga aacccaagca gagaaagttg ttttggagaa agaagtacat      360

gatcagcttt tacagctgca ctctattcag ctgcagcttc atgctaaaac tggtcaaagt      420

gctgactctg gtaccattaa ggcaaaattg gaaagagagc ttgaggcaaa caaaaaagaa      480

aaaatgaaag aagcacaact tgaagctgaa gtgaaattgt tgagaaaaga gaatgaagcc      540

cttcgtagac atatagctgt tctccaggct gaagtatatg gggcgagact agctgccaag      600

tacttggata aggaactggc aggaagggtc caacagatac aattgctagg acgagatatg      660

aagggacctg ctcatgataa gctttggaac caattagaag ctgaaataca tttgcatcgt      720

cacaaaactg tgatccgagc ctgcagagga cgtaatgact tgaaacgacc aatgcaagca      780

ccaccaggcc atgatcaaga ttccctaaag aaaagccaag gtgttggtcc aattagaaaa      840

gttctcctcc ttaaggaaga tcatgaaggc cttggcattt caattacagg tgggaaagaa      900

catggtgttc caatcctcat ctctgagatc catccggggc aacctgctga tagatgcgga      960

gggctgcacg ttggggatgc tattttggca gtcaacggag ttaacctaag ggacacaaag     1020

cataaagaag ctgtaactat tctttctcag cagagaggag agattgaatt tgaagtagtt     1080

tatgtggctc ctgaagtgga ttctgatgat gaaaacgtag agtatgaaga tgagagtgga     1140

catcgttacc gtttgtacct tgatgagtta gaaggaggtg gtaaccctgg tgctagttgc     1200

aaagacacaa gtggggaaat caaagtatta caagtctggc atagaagatt aaagaatcaa     1260

aaaagtgcca aggaaggggt gacagtgctt ataaacgaag acaaagagtt ggctgagctg     1320

cgaggtctgg cagccggagt aggcctggct aatgcctgct atgcaataca tactcttcca     1380

acccaagagg agattgaaaa tcttcctgcc ttccctcggg aaaaactgac tctgcgtctc     1440

ttgctgggaa gtggagcctt tggagaagtg tatgaaggaa cagcagtgga catcttagga     1500

gttggaagtg gagaaatcaa agtagcagtg aagactttga agaagggttc cacagaccag     1560

gagaagattg aattcctgaa ggaggcacat ctgatgagca aatttaatca tcccaacatt     1620

ctgaagcagc ttggagtttg tctgctgaat gaaccccaat acattatcct ggaactgatg     1680

gagggaggag accttcttac ttatttgcgt aaagcccgga tggcaacgtt ttatggtcct     1740

ttactcacct tggttgacct tgtagacctg tgtgtagata tttcaaaagg ctgtgtctac     1800

ttggaacgga tgcatttcat tcacagggat ctggcagcta gaaattgcct tgtttccgtg     1860

aaagactata ccagtccacg gatagtgaag attggagact ttggactcgc cagagacatc     1920

tataaaaatg attactatag aaagagaggg gaaggcctgc tcccagttcg gtggatggct     1980

ccagaaagtt tgatggatgg aatcttcact actcaatctg atgtatggtc ttttggaatt     2040

ctgatttggg agattttaac tcttggtcat cagccttatc cagctcattc caaccttgat     2100

gtgttaaact atgtgcaaac aggagggaga ctggagccac caagaaattg tcctgatgat     2160

ctgtggaatt taatgaccca gtgctgggct caagaacccg accaaagacc tacttttcat     2220

agaattcagg accaacttca gttattcaga aattttttct taaatagcat ttataagtcc     2280

agagatgaag caaacaacag tggagtcata aatgaaagct ttgaaggtga agatggcgat     2340

gtgatttgtt tgaattcaga tgacattatg ccagttgctt taatggaaac gaagaaccga     2400

gaagggttaa actatatggt acttgctaca gaatgtggcc aaggtgaaga aaagtctgag     2460

ggtcctctag gctcccagga atctgaatct tgtggtctga ggaaagaaga gaaggaacca     2520

catgcagaca aagatttctg ccaagaaaaa caagtggctt actgcccttc tggcaagcct     2580

gaaggcctga actatgcctg tctcactcac agtggatatg gagatgggtc tgattaa        2637


<210>  56
<211>  878
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  56

Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg 
            20                  25                  30          


Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val 
        35                  40                  45              


Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu 
65                  70                  75                  80  


Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala 
                85                  90                  95      


Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys 
            100                 105                 110         


Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser 
        115                 120                 125             


Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly 
    130                 135                 140                 


Thr Ile Lys Ala Lys Leu Glu Arg Glu Leu Glu Ala Asn Lys Lys Glu 
145                 150                 155                 160 


Lys Met Lys Glu Ala Gln Leu Glu Ala Glu Val Lys Leu Leu Arg Lys 
                165                 170                 175     


Glu Asn Glu Ala Leu Arg Arg His Ile Ala Val Leu Gln Ala Glu Val 
            180                 185                 190         


Tyr Gly Ala Arg Leu Ala Ala Lys Tyr Leu Asp Lys Glu Leu Ala Gly 
        195                 200                 205             


Arg Val Gln Gln Ile Gln Leu Leu Gly Arg Asp Met Lys Gly Pro Ala 
    210                 215                 220                 


His Asp Lys Leu Trp Asn Gln Leu Glu Ala Glu Ile His Leu His Arg 
225                 230                 235                 240 


His Lys Thr Val Ile Arg Ala Cys Arg Gly Arg Asn Asp Leu Lys Arg 
                245                 250                 255     


Pro Met Gln Ala Pro Pro Gly His Asp Gln Asp Ser Leu Lys Lys Ser 
            260                 265                 270         


Gln Gly Val Gly Pro Ile Arg Lys Val Leu Leu Leu Lys Glu Asp His 
        275                 280                 285             


Glu Gly Leu Gly Ile Ser Ile Thr Gly Gly Lys Glu His Gly Val Pro 
    290                 295                 300                 


Ile Leu Ile Ser Glu Ile His Pro Gly Gln Pro Ala Asp Arg Cys Gly 
305                 310                 315                 320 


Gly Leu His Val Gly Asp Ala Ile Leu Ala Val Asn Gly Val Asn Leu 
                325                 330                 335     


Arg Asp Thr Lys His Lys Glu Ala Val Thr Ile Leu Ser Gln Gln Arg 
            340                 345                 350         


Gly Glu Ile Glu Phe Glu Val Val Tyr Val Ala Pro Glu Val Asp Ser 
        355                 360                 365             


Asp Asp Glu Asn Val Glu Tyr Glu Asp Glu Ser Gly His Arg Tyr Arg 
    370                 375                 380                 


Leu Tyr Leu Asp Glu Leu Glu Gly Gly Gly Asn Pro Gly Ala Ser Cys 
385                 390                 395                 400 


Lys Asp Thr Ser Gly Glu Ile Lys Val Leu Gln Val Trp His Arg Arg 
                405                 410                 415     


Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile Asn 
            420                 425                 430         


Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val Gly 
        435                 440                 445             


Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu Glu 
    450                 455                 460                 


Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu 
465                 470                 475                 480 


Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val 
                485                 490                 495     


Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr 
            500                 505                 510         


Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu 
        515                 520                 525             


Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu 
    530                 535                 540                 


Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met 
545                 550                 555                 560 


Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr 
                565                 570                 575     


Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val 
            580                 585                 590         


Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile His 
        595                 600                 605             


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr Thr 
    610                 615                 620                 


Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile 
625                 630                 635                 640 


Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro Val 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr Gln 
            660                 665                 670         


Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu 
        675                 680                 685             


Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn Tyr 
    690                 695                 700                 


Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp 
705                 710                 715                 720 


Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg 
                725                 730                 735     


Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn Phe 
            740                 745                 750         


Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser Gly 
        755                 760                 765             


Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys Leu 
    770                 775                 780                 


Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn Arg 
785                 790                 795                 800 


Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu 
                805                 810                 815     


Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly 
            820                 825                 830         


Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys Gln 
        835                 840                 845             


Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn 
    850                 855                 860                 


Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
865                 870                 875             


<210>  57
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  57
atgtcggcgg gcggtccatg cccagcagca gccggagggg gcccaggggg cgcctcctgc       60

tccgtggggg cccctggcgg ggtatccatg ttccggtggc tggaggtgct ggagaaggag      120

ttcgacaaag cttttgtgga tgtggatctg ctcctgggag agatcgatcc agaccaagcg      180

gacatcactt atgaggggcg acagaagatg accagcctga gctcctgctt tgcacagctt      240

tgccacaaag cccagtctgt gtctcaaatc aaccacaagc tggaggcaca gttggtggat      300

ctgaaatctg aactgacaga aacccaagca gagaaagttg ttttggagaa agaagtacat      360

gatcagcttt tacagctgca ctctattcag ctgcagcttc atgctaaaac tggtcaaagt      420

gctgactctg gtaccattaa ggcaaaattg gaaagagagc ttgaggcaaa caaaaaagaa      480

aaaatgaaag aagcacaact tgaagctgaa gtgaaattgt tgagaaaaga gaatgaagcc      540

cttcgtagac atatagctgt tctccaggct gaagtatatg gggcgagact agctgccaag      600

tacttggata aggaactggc aggaagtact cttccaaccc aagaggagat tgaaaatctt      660

cctgccttcc ctcgggaaaa actgactctg cgtctcttgc tgggaagtgg agcctttgga      720

gaagtgtatg aaggaacagc agtggacatc ttaggagttg gaagtggaga aatcaaagta      780

gcagtgaaga ctttgaagaa gggttccaca gaccaggaga agattgaatt cctgaaggag      840

gcacatctga tgagcaaatt taatcatccc aacattctga agcagcttgg agtttgtctg      900

ctgaatgaac cccaatacat tatcctggaa ctgatggagg gaggagacct tcttacttat      960

ttgcgtaaag cccggatggc aacgttttat ggtcctttac tcaccttggt tgaccttgta     1020

gacctgtgtg tagatatttc aaaaggctgt gtctacttgg aacggatgca tttcattcac     1080

agggatctgg cagctagaaa ttgccttgtt tccgtgaaag actataccag tccacggata     1140

gtgaagattg gagactttgg actcgccaga gacatctata aaaatgatta ctatagaaag     1200

agaggggaag gcctgctccc agttcggtgg atggctccag aaagtttgat ggatggaatc     1260

ttcactactc aatctgatgt atggtctttt ggaattctga tttgggagat tttaactctt     1320

ggtcatcagc cttatccagc tcattccaac cttgatgtgt taaactatgt gcaaacagga     1380

gggagactgg agccaccaag aaattgtcct gatgatctgt ggaatttaat gacccagtgc     1440

tgggctcaag aacccgacca aagacctact tttcatagaa ttcaggacca acttcagtta     1500

ttcagaaatt ttttcttaaa tagcatttat aagtccagag atgaagcaaa caacagtgga     1560

gtcataaatg aaagctttga aggtgaagat ggcgatgtga tttgtttgaa ttcagatgac     1620

attatgccag ttgctttaat ggaaacgaag aaccgagaag ggttaaacta tatggtactt     1680

gctacagaat gtggccaagg tgaagaaaag tctgagggtc ctctaggctc ccaggaatct     1740

gaatcttgtg gtctgaggaa agaagagaag gaaccacatg cagacaaaga tttctgccaa     1800

gaaaaacaag tggcttactg cccttctggc aagcctgaag gcctgaacta tgcctgtctc     1860

actcacagtg gatatggaga tgggtctgat taa                                  1893


<210>  58
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  58

Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg 
            20                  25                  30          


Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val 
        35                  40                  45              


Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu 
65                  70                  75                  80  


Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala 
                85                  90                  95      


Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys 
            100                 105                 110         


Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser 
        115                 120                 125             


Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly 
    130                 135                 140                 


Thr Ile Lys Ala Lys Leu Glu Arg Glu Leu Glu Ala Asn Lys Lys Glu 
145                 150                 155                 160 


Lys Met Lys Glu Ala Gln Leu Glu Ala Glu Val Lys Leu Leu Arg Lys 
                165                 170                 175     


Glu Asn Glu Ala Leu Arg Arg His Ile Ala Val Leu Gln Ala Glu Val 
            180                 185                 190         


Tyr Gly Ala Arg Leu Ala Ala Lys Tyr Leu Asp Lys Glu Leu Ala Gly 
        195                 200                 205             


Ser Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro 
    210                 215                 220                 


Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly 
225                 230                 235                 240 


Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly 
                245                 250                 255     


Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln 
            260                 265                 270         


Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn 
        275                 280                 285             


His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro 
    290                 295                 300                 


Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr 
305                 310                 315                 320 


Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu 
                325                 330                 335     


Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr 
            340                 345                 350         


Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
        355                 360                 365             


Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys 
385                 390                 395                 400 


Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu 
                405                 410                 415     


Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile 
            420                 425                 430         


Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His 
        435                 440                 445             


Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu 
    450                 455                 460                 


Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys 
465                 470                 475                 480 


Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp 
                485                 490                 495     


Gln Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser 
            500                 505                 510         


Arg Asp Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly 
        515                 520                 525             


Glu Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val 
    530                 535                 540                 


Ala Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu 
545                 550                 555                 560 


Ala Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly 
                565                 570                 575     


Ser Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro 
            580                 585                 590         


His Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro 
        595                 600                 605             


Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly 
    610                 615                 620                 


Tyr Gly Asp Gly Ser Asp 
625                 630 


<210>  59
<211>  3030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  59
atgtcggcgg gcggtccatg cccagcagca gccggagggg gcccaggggg cgcctcctgc       60

tccgtggggg cccctggcgg ggtatccatg ttccggtggc tggaggtgct ggagaaggag      120

ttcgacaaag cttttgtgga tgtggatctg ctcctgggag agatcgatcc agaccaagcg      180

gacatcactt atgaggggcg acagaagatg accagcctga gctcctgctt tgcacagctt      240

tgccacaaag cccagtctgt gtctcaaatc aaccacaagc tggaggcaca gttggtggat      300

ctgaaatctg aactgacaga aacccaagca gagaaagttg ttttggagaa agaagtacat      360

gatcagcttt tacagctgca ctctattcag ctgcagcttc atgctaaaac tggtcaaagt      420

gctgactctg gtaccattaa ggcaaaattg gaaagagagc ttgaggcaaa caaaaaagaa      480

aaaatgaaag aagcacaact tgaagctgaa gtgaaattgt tgagaaaaga gaatgaagcc      540

cttcgtagac atatagctgt tctccaggct gaagtatatg gggcgagact agctgccaag      600

tacttggata aggaactggc aggaagggtc caacagatac aattgctagg acgagatatg      660

aagggacctg ctcatgataa gctttggaac caattagaag ctgaaataca tttgcatcgt      720

cacaaaactg tgatccgagc ctgcagagga cgtaatgact tgaaacgacc aatgcaagca      780

ccaccaggcc atgatcaaga ttccctaaag aaaagccaag gtgttggtcc aattagaaaa      840

gttctcctcc ttaaggaaga tcatgaaggc cttggcattt caattacagg tgggaaagaa      900

catggtgttc caatcctcat ctctgagatc catccggggc aacctgctga tagatgcgga      960

gggctgcacg ttggggatgc tattttggca gtcaacggag ttaacctaag ggacacaaag     1020

cataaagaag ctgtaactat tctttctcag cagagaggag agattgaatt tgaagtagtt     1080

tatgtggctc ctgaagtgga ttctgatgat gaaaacgtag agtatgaaga tgagagtgga     1140

catcgttacc gtttgtacct tgatgagtta gaaggaggtg gtaaccctgg tgctagttgc     1200

aaagacacaa gtggggaaat caaagtatta caagctggag tcccaaataa accaggcatt     1260

cccaaattac tagaagggag taaaaattca atacagtggg agaaagctga agataatgga     1320

tgtagaatta catactatat ccttgagata agaaagagca cttcaaataa tttacagaac     1380

cagaatttaa ggtggaagat gacatttaat ggatcctgca gtagtgtttg cacatggaag     1440

tccaaaaacc tgaaaggaat atttcagttc agagtagtag ctgcaaataa tctagggttt     1500

ggtgaatata gtggaatcag tgagaatatt atattagttg gagatgattt ttggatacca     1560

gaaacaagtt tcatacttac tattatagtt ggaatatttc tggttgttac aatcccactg     1620

acctttgtct ggcatagaag attaaagaat caaaaaagtg ccaaggaagg ggtgacagtg     1680

cttataaacg aagacaaaga gttggctgag ctgcgaggtc tggcagccgg agtaggcctg     1740

gctaatgcct gctatgcaat acatactctt ccaacccaag aggagattga aaatcttcct     1800

gccttccctc gggaaaaact gactctgcgt ctcttgctgg gaagtggagc ctttggagaa     1860

gtgtatgaag gaacagcagt ggacatctta ggagttggaa gtggagaaat caaagtagca     1920

gtgaagactt tgaagaaggg ttccacagac caggagaaga ttgaattcct gaaggaggca     1980

catctgatga gcaaatttaa tcatcccaac attctgaagc agcttggagt ttgtctgctg     2040

aatgaacccc aatacattat cctggaactg atggagggag gagaccttct tacttatttg     2100

cgtaaagccc ggatggcaac gttttatggt cctttactca ccttggttga ccttgtagac     2160

ctgtgtgtag atatttcaaa aggctgtgtc tacttggaac ggatgcattt cattcacagg     2220

gatctggcag ctagaaattg ccttgtttcc gtgaaagact ataccagtcc acggatagtg     2280

aagattggag actttggact cgccagagac atctataaaa atgattacta tagaaagaga     2340

ggggaaggcc tgctcccagt tcggtggatg gctccagaaa gtttgatgga tggaatcttc     2400

actactcaat ctgatgtatg gtcttttgga attctgattt gggagatttt aactcttggt     2460

catcagcctt atccagctca ttccaacctt gatgtgttaa actatgtgca aacaggaggg     2520

agactggagc caccaagaaa ttgtcctgat gatctgtgga atttaatgac ccagtgctgg     2580

gctcaagaac ccgaccaaag acctactttt catagaattc aggaccaact tcagttattc     2640

agaaattttt tcttaaatag catttataag tccagagatg aagcaaacaa cagtggagtc     2700

ataaatgaaa gctttgaagg tgaagatggc gatgtgattt gtttgaattc agatgacatt     2760

atgccagttg ctttaatgga aacgaagaac cgagaagggt taaactatat ggtacttgct     2820

acagaatgtg gccaaggtga agaaaagtct gagggtcctc taggctccca ggaatctgaa     2880

tcttgtggtc tgaggaaaga agagaaggaa ccacatgcag acaaagattt ctgccaagaa     2940

aaacaagtgg cttactgccc ttctggcaag cctgaaggcc tgaactatgc ctgtctcact     3000

cacagtggat atggagatgg gtctgattaa                                      3030


<210>  60
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  60

Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg 
            20                  25                  30          


Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val 
        35                  40                  45              


Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu 
65                  70                  75                  80  


Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala 
                85                  90                  95      


Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys 
            100                 105                 110         


Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser 
        115                 120                 125             


Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly 
    130                 135                 140                 


Thr Ile Lys Ala Lys Leu Glu Arg Glu Leu Glu Ala Asn Lys Lys Glu 
145                 150                 155                 160 


Lys Met Lys Glu Ala Gln Leu Glu Ala Glu Val Lys Leu Leu Arg Lys 
                165                 170                 175     


Glu Asn Glu Ala Leu Arg Arg His Ile Ala Val Leu Gln Ala Glu Val 
            180                 185                 190         


Tyr Gly Ala Arg Leu Ala Ala Lys Tyr Leu Asp Lys Glu Leu Ala Gly 
        195                 200                 205             


Arg Val Gln Gln Ile Gln Leu Leu Gly Arg Asp Met Lys Gly Pro Ala 
    210                 215                 220                 


His Asp Lys Leu Trp Asn Gln Leu Glu Ala Glu Ile His Leu His Arg 
225                 230                 235                 240 


His Lys Thr Val Ile Arg Ala Cys Arg Gly Arg Asn Asp Leu Lys Arg 
                245                 250                 255     


Pro Met Gln Ala Pro Pro Gly His Asp Gln Asp Ser Leu Lys Lys Ser 
            260                 265                 270         


Gln Gly Val Gly Pro Ile Arg Lys Val Leu Leu Leu Lys Glu Asp His 
        275                 280                 285             


Glu Gly Leu Gly Ile Ser Ile Thr Gly Gly Lys Glu His Gly Val Pro 
    290                 295                 300                 


Ile Leu Ile Ser Glu Ile His Pro Gly Gln Pro Ala Asp Arg Cys Gly 
305                 310                 315                 320 


Gly Leu His Val Gly Asp Ala Ile Leu Ala Val Asn Gly Val Asn Leu 
                325                 330                 335     


Arg Asp Thr Lys His Lys Glu Ala Val Thr Ile Leu Ser Gln Gln Arg 
            340                 345                 350         


Gly Glu Ile Glu Phe Glu Val Val Tyr Val Ala Pro Glu Val Asp Ser 
        355                 360                 365             


Asp Asp Glu Asn Val Glu Tyr Glu Asp Glu Ser Gly His Arg Tyr Arg 
    370                 375                 380                 


Leu Tyr Leu Asp Glu Leu Glu Gly Gly Gly Asn Pro Gly Ala Ser Cys 
385                 390                 395                 400 


Lys Asp Thr Ser Gly Glu Ile Lys Val Leu Gln Ala Gly Val Pro Asn 
                405                 410                 415     


Lys Pro Gly Ile Pro Lys Leu Leu Glu Gly Ser Lys Asn Ser Ile Gln 
            420                 425                 430         


Trp Glu Lys Ala Glu Asp Asn Gly Cys Arg Ile Thr Tyr Tyr Ile Leu 
        435                 440                 445             


Glu Ile Arg Lys Ser Thr Ser Asn Asn Leu Gln Asn Gln Asn Leu Arg 
    450                 455                 460                 


Trp Lys Met Thr Phe Asn Gly Ser Cys Ser Ser Val Cys Thr Trp Lys 
465                 470                 475                 480 


Ser Lys Asn Leu Lys Gly Ile Phe Gln Phe Arg Val Val Ala Ala Asn 
                485                 490                 495     


Asn Leu Gly Phe Gly Glu Tyr Ser Gly Ile Ser Glu Asn Ile Ile Leu 
            500                 505                 510         


Val Gly Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu Thr Ile 
        515                 520                 525             


Ile Val Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr Phe Val Trp 
    530                 535                 540                 


His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val 
545                 550                 555                 560 


Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala 
                565                 570                 575     


Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr 
            580                 585                 590         


Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr 
        595                 600                 605             


Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly 
    610                 615                 620                 


Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala 
625                 630                 635                 640 


Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe 
                645                 650                 655     


Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu 
            660                 665                 670         


Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu 
        675                 680                 685             


Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg 
    690                 695                 700                 


Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp 
705                 710                 715                 720 


Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His 
                725                 730                 735     


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys 
            740                 745                 750         


Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala 
        755                 760                 765             


Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu 
    770                 775                 780                 


Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe 
785                 790                 795                 800 


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile 
                805                 810                 815     


Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val 
            820                 825                 830         


Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys 
        835                 840                 845             


Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro 
    850                 855                 860                 


Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe 
865                 870                 875                 880 


Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn 
                885                 890                 895     


Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val 
            900                 905                 910         


Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr 
        915                 920                 925             


Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly 
    930                 935                 940                 


Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu 
945                 950                 955                 960 


Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp 
                965                 970                 975     


Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu 
            980                 985                 990         


Gly Leu Asn Tyr Ala Cys Leu Thr  His Ser Gly Tyr Gly  Asp Gly Ser 
        995                 1000                 1005             


Asp 
    


<210>  61
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  61

Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr 
1               5                   10                  15      


Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys 
            20                  25                  30          


Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile 
        35                  40                  45              


Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn 
    50                  55                  60                  


Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile 
65                  70                  75                  80  


Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys 
                85                  90                  95      


Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu 
            100                 105                 110         


Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg 
        115                 120                 125             


Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser 
    130                 135                 140                 


Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu 
                165                 170                 175     


Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly 
            180                 185                 190         


Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp 
        195                 200                 205             


Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu 
    210                 215                 220                 


Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg 
225                 230                 235                 240 


Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln 
                245                 250                 255     


Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln 
            260                 265                 270         


Leu Phe Arg Asn Phe Phe 
        275             


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  62

Val Gly Val Trp His Arg 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  63

Leu Val Gly Asp Asp Phe 
1               5       


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  64

Leu Val Gly Ala Gly Val 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Seuqnece

<220>
<223>  Synthetic Peptide

<400>  65

Pro Pro Lys Asp Asp Phe 
1               5       


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  66

Ala Gly Ser Thr Leu Pro 
1               5       


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  67

Leu Gln Val Trp His Arg 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  68

Val Leu Gln Ala Gly Val 
1               5       


