                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Deng, Zhengwu James
       Liao, Hongbiao
       Stanton, Matthew G.
 
<120>  RING CONSTRAINED CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY

<130>  23071

<150>  US 61/490,300
<150>  2011-05-26

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(17)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  1
auaaggcuau gaagagauat t                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  ribose

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-o-methyl

<400>  2
uaucucuuca uagccuuauu u                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phophorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  3
cuuuaacaau uccugaaaut t                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  ribose

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phophorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-o-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phophorothioate linkage

<400>  4
auuucaggaa uuguuaaagu u                                                 21


