                         SEQUENCE LISTING

<110>  Richter-Helm BioTech GmbH & Co. KG
 
<120>  RECOMBINANT EXPRESSION OF SOLUBLE INTERFERON

<130>  P 87785

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu 
1               5                   10                  15      


Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met 
            100                 105                 110         


Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Lys Glu 
                165     


<210>  2
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  3
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  4
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtgcgatc tgccgcagac ccatagcctg ggcagccgtc gtaccctgat gctgctggcc     60

cagatgcgta aaattagcct gtttagctgc ctgaaagatc gtcatgattt tggctttccg    120

caggaagaat ttggcaacca gtttcagaaa gcggaaacca ttccggtgct gcatgaaatg    180

attcagcaga tcttcaacct gtttagcacc aaagatagca gcgcggcgtg ggatgaaacc    240

ctgctggata aattctatac cgaactgtat cagcagctga acgatctgga agcgtgcgtg    300

attcagggcg tgggcgtgac cgaaaccccg ctgatgaaag aagatagcat tctggccgtg    360

cgtaaatatt ttcagcgcat caccctgtat ctgaaagaaa aaaaatatag cccgtgcgcg    420

tgggaagtgg tgcgtgcgga aattatgcgt agctttagcc tgagcaccaa cctgcaggaa    480

agcctgcgta gcaaagaata ataa                                           504


<210>  5
<211>  1353
<212>  DNA
<213>  Escherichia coli

<400>  5
atgactaaac actatgatta catcgccatc ggcggcggca gcggcggtat cgcctccatc     60

aaccgcgcgg ctatgtacgg ccagaaatgt gcgctgattg aagccaaaga gctgggcggc    120

acctgcgtaa atgttggctg tgtgccgaaa aaagtgatgt ggcacgcggc gcaaatccgt    180

gaagcgatcc atatgtacgg cccggattat ggttttgata ccactatcaa taaattcaac    240

tgggaaacgt tgatcgccag ccgtaccgcc tatatcgacc gtattcatac ttcctatgaa    300

aacgtgctcg gtaaaaataa cgttgatgta atcaaaggct ttgcccgctt cgttgatgcc    360

aaaacgctgg aggtaaacgg cgaaaccatc acggccgatc atattctgat cgccacaggc    420

ggtcgtccga gccacccgga tattccgggc gtggaatacg gtattgattc tgatggcttc    480

ttcgcccttc ctgctttgcc agagcgcgtg gcggttgttg gcgcgggtta catcgccgtt    540

gagctggcgg gcgtgattaa cggcctcggc gcgaaaacgc atctgtttgt gcgtaaacat    600

gcgccgctgc gcagcttcga cccgatgatt tccgaaacgc tggtcgaagt gatgaacgcc    660

gaaggcccgc agctgcacac caacgccatc ccgaaagcgg tagtgaaaaa taccgatggt    720

agcctgacgc tggagctgga agatggtcgc agtgaaacgg tggattgcct gatttgggcg    780

attggtcgcg agcctgccaa tgacaacatc aacctggaag ccgctggcgt taaaactaac    840

gaaaaaggct atatcgtcgt cgataaatat caaaacacca atattgaagg tatttacgcg    900

gtgggcgata acacgggtgc agtggagctg acaccggtgg cagttgcagc gggtcgccgt    960

ctctctgaac gcctgtttaa taacaagccg gatgagcatc tggattacag caacattccg   1020

accgtggtct tcagccatcc gccgattggt actgttggtt taacggaacc gcaggcgcgc   1080

gagcagtatg gcgacgatca ggtgaaagtg tataaatcct ctttcaccgc gatgtatacc   1140

gccgtcacca ctcaccgcca gccgtgccgc atgaagctgg tgtgcgttgg atcggaagag   1200

aagattgtcg gtattcacgg cattggcttt ggtatggacg aaatgttgca gggcttcgcg   1260

gtggcgctga agatgggggc aaccaaaaaa gacttcgaca ataccgtcgc cattcaccca   1320

acggcggcag aagagttcgt gacaatgcgt taa                                1353


<210>  6
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  6
gtccgactta tgcccgagaa gatgttgagc aaacttatcg cttatc                    46


<210>  7
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
tgcaaagaga ttcttggcgg agaaaccata attgcatcta ctcg                      44


<210>  8
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
ggaagcgggc ctgcagcgga caccatcgaa tggcgc                               36


<210>  9
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
gggggggggg gtcgacggag tcgtattgat ttggcg                               36


<210>  10
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
tcgctatcat ctacagagaa atccggcgtt gagttcgggt tgctcagcag ctagatgcat     60

gctcgagcgg                                                            70


<210>  11
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
gtaaaggctc catcatgcgc ctgggtgaag accgttccat ggatgtggaa ctctgctgaa     60

gccagttacc                                                            70


<210>  12
<211>  73
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
aacgtgctcg gtaaaaataa cgttgatgta atcaaaggct ttgcccgctt aattaaccct     60

cactaaaggg cgg                                                        73


<210>  13
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
gatcggccgt gatggtttcg ccgtttacct ccagcgtttt ggcatcaacg taatacgact     60

cactataggg ctcg                                                       74


<210>  14
<211>  73
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
caccaagttt gaaactgaga tcatttttga tcatatcaac aaggtggatc aattaaccct     60

cactaaaggg cgg                                                        73


<210>  15
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
gcaagtgtat tcgccgttat cgccattcag acggaacgga cggttttgca taatacgact     60

cactataggg ctcg                                                       74


