                         SEQUENCE LISTING

<110>  Universit Degli Studi di Roma "La Sapienza"
       BARNABA, Vincenzo
 
<120>  METHOD TO PROGNOSE VIRAL INFECTION BY MEASURING T CELL RESPONSE 
       OR AUTO-ANTIBODIES TO APOPTOTIC EPITOPES

<130>  PCT 117415

<150>  RM2011A000248
<151>  2011-05-20

<160>  379   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Met Tyr Val Ala Ile Gln Ala Val 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Leu Ala Pro Ser Thr Met Lys Ile 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Leu Pro His Ala Ile Leu Arg Leu 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Leu Gly Met Glu Ser Cys Gly Ile 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Met Gln Lys Glu Ile Thr Ala Leu 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Leu Lys Tyr Pro Ile Glu His Gly Ile 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Met Tyr Val Ala Ile Gln Ala Val Leu 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Leu Ser Thr Phe Gln Gln Met Trp Ile 
1               5                   10  


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Met Gly Gln Lys Asp Ser Tyr Val 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Leu Pro Asp Gly Gln Val Ile Thr Ile 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Leu Thr Asp Tyr Leu Met Lys Ile 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Leu Asp Leu Ala Gly Arg Asp Leu 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Leu Thr Asp Tyr Leu Met Lys Ile Leu 
1               5                   10  


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Leu Ala Gly Gly Ile Ile Gly Val 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Met Val Glu Leu Arg Ile Leu Leu 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val 
1               5                   10  


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Leu Lys Lys Ile Ile Pro Thr Leu 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Leu Ile Gly Gly Lys Pro Asp Arg Val 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Leu Pro Leu Glu Ser Asp Ala Val 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Leu Gln Ser Lys Asn Ala Gly Ala Val 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Leu Arg Leu Leu Ile His Gln Ser Leu 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Pro Leu Glu Gly Ser Glu Asp Arg Ile 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Leu Glu Ser Asp Ala Val Glu Cys Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Leu Arg Glu Asn Thr Gln Thr Thr Ile 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Pro Leu Glu Gly Ser Glu Asp Arg Ile Ile 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Thr Ile Trp Ala Ala Asn Ala Gly Val 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Leu Ala Val Tyr Ile Asp Lys Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Leu Ser Ser Gln Leu Ser Asn Leu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Leu Leu Asp Val Lys Leu Ala Leu 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Leu Ala Asp Glu Thr Leu Leu Lys Val 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Lys Leu Arg Glu Tyr Glu Ala Ala Leu 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Leu Asn Ser Lys Asp Ala Ala Leu 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Leu Met Glu Ser Arg Met Arg Ile 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Leu Asn Asp Tyr Glu Gln Leu Leu 
1               5                   


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Lys Leu Ser Pro Ser Pro Ser Ser Arg Val 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Leu Lys Ala Gly Gln Thr Val Thr Ile 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Leu Gln Val Thr Glu Arg Glu Glu Val 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Ile Leu Lys Asn Ser Gln Gly Glu Glu Val 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Leu Glu Thr Glu Asn Ser Ala Leu 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Leu Ala Asp Ala Arg Arg Ala Leu 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Leu Glu Gly Asp Leu Glu Asp Leu 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Leu Lys Asp Gln Ile Ala Gln Leu 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Leu Ala Ala Ala Lys Lys Gln Leu 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Leu Glu Gly Glu Glu Glu Arg Leu 
1               5                   


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Leu Lys Ala Leu Tyr Glu Thr Glu Leu 
1               5                   10  


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Leu Arg Glu Leu Asn Asp Arg Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Leu Asn Gly Ala Gln Ile Lys Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Leu Glu Asp Leu Lys Asp Gln Ile 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Leu Glu Asn Arg Cys Gln Ser Leu 
1               5                   


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Met Arg Glu Gln His Asp Ala Gln Val 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Leu Glu Gln Thr Tyr His Ala Lys Leu 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu 
1               5                   10  


<210>  58
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  58

Tyr Leu Tyr Val Asp Lys Asn Phe Ile 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Leu Ile Tyr Thr Tyr Ser Gly Leu 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Tyr Thr Tyr Ser Gly Leu Phe Cys Val 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Asn Leu Pro Ile Tyr Ser Glu Glu Ile 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Met Pro Pro His Ile Tyr Ala Ile 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Val Ile Gln Tyr Leu Ala Tyr Val 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Leu Phe Asn His Thr Met Phe Ile 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  65

Trp Leu Met Lys Asn Met Asp Pro Leu 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Leu Ala Lys Leu Met Ala Thr Leu 
1               5                   


<210>  67
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  67

Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  68

Arg Met Phe Arg Trp Leu Val Leu Arg Ile 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Leu Phe Asn His Thr Met Phe Ile Leu 
1               5                   10  


<210>  70
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  70

Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  71

Arg Thr Phe His Ile Phe Tyr Tyr Leu 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Leu Ser Gly Ala Gly Glu His Leu 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  73

Phe Leu Ser Asn Gly His Val Thr Ile 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Leu Leu Arg Val Ile Ser Gly Val 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  75

Phe Ala Ile Glu Ala Leu Ala Lys Ala 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Ile Leu Asp Ile Ala Gly Phe Glu Ile 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  77

Phe Met Asp Gly Lys Gln Ala Cys Val 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  78

Val Leu Met Ile Lys Ala Leu Glu Leu 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  79

Arg Leu Phe Thr Lys Val Lys Pro Leu 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Leu Gln Ala Ala Leu Ala Arg Val 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  81

Lys Leu Gln Val Glu Leu Asp Asn Val 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  82

Ser Leu Ser Thr Lys Leu Lys Gln Val 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  83

Lys Leu Lys Asp Val Leu Leu Gln Val 
1               5                   


<210>  84
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  84

Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  85

Thr Met Glu Ala Met Arg Ile Met Gly Ile 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  86

Gly Leu Leu Arg Val Ile Ser Gly Val Leu 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Leu Tyr Lys Glu Gln Leu Ala Lys Leu 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Met Asp Gly Lys Gln Ala Cys Val Leu 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  89

Lys Leu Arg Arg Gly Asp Leu Pro Phe Val 
1               5                   10  


<210>  90
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  90

Gln Leu Leu Gln Ala Asn Pro Ile Leu 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Met Ala Lys Glu Glu Glu Leu Val 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Leu Met Ala Glu Lys Leu Gln Leu 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  93

Lys Met Gln Gln Asn Ile Gln Glu Leu 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  94

Glu Leu Ala Asp Lys Val Thr Lys Leu 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Lys Leu Thr Lys Asp Phe Ser Ala Leu 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Lys Met Glu Asp Ser Val Gly Cys Leu 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  97

Lys Leu Gln Lys Asp Leu Glu Gly Leu 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  98

Glu Met Lys Thr Gln Leu Glu Glu Leu 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  99

Arg Leu Glu Ala Arg Ile Ala Gln Leu 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Lys Leu Gln Glu Met Glu Gly Thr Val 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Ala Leu Glu Ala Lys Ile Ala Gln Leu 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Met Asn Arg Glu Val Ser Ser Leu 
1               5                   


<210>  103
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Met Asn Pro Pro Lys Phe Ser Lys Val 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  104

Thr Leu Arg Asn Thr Asn Pro Asn Phe Val 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  105

Val Leu Asp Gln Leu Arg Cys Asn Gly Val 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  106

Asn Leu Tyr Arg Ile Gly Gln Ser Lys Val 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Leu Gln Arg Asn Cys Ala Ala Tyr Leu 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Leu Phe Thr Lys Val Lys Pro Leu Leu 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Ala Met Ile Thr Asp Leu Glu Glu Arg Leu 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  110

Glu Leu Ala Asn Glu Val Lys Val Leu Leu 
1               5                   10  


<210>  111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  111

Tyr Ile Val Gly Ala Asn Ile Glu Thr 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Pro Leu Asn Asp Asn Ile Ala Thr Leu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  113

Gly Met Phe Arg Thr Val Gly Gln Leu 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Lys Leu Glu Glu Glu Gln Ile Ile Leu 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  115

Ile Leu Glu Asp Gln Asn Cys Lys Leu 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Leu Gln Asp Thr Gln Glu Leu Leu 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  117

Gln Leu Glu Glu Leu Glu Asp Glu Leu 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  118

Gln Met Lys Asp Cys Met Arg Glu Leu 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  119

Ser Met Glu Ala Glu Met Ile Gln Leu 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Met Ile Gln Leu Gln Glu Glu Leu 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  121

Arg Leu Lys Lys Ala Asn Leu Gln Ile 
1               5                   


<210>  122
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  122

Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Met Gln Asp Arg Glu Asp Gln Ser Ile 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  124

Trp Leu Val Leu Arg Ile Asn Lys Ala Leu 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  125

Leu Leu His Gln Ser Ser Asp Lys Phe Val 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  126

Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Met Met Ala Lys Glu Glu Glu Leu Val 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Ala Leu Lys Thr Glu Leu Glu Asp Thr Leu 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  129

Leu Leu Gln Glu Glu Asn Arg Gln Lys Leu 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  130

Arg Leu Gln Gln Glu Leu Asp Asp Leu Leu 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  131

Lys Leu Lys Ser Met Glu Ala Glu Met Ile 
1               5                   10  


<210>  132
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  132

Leu Leu Arg Val Ile Ser Gly Val Leu 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  133

Asn Met Asp Pro Leu Asn Asp Asn Ile 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Glu Leu Asp Ser Asn Leu Tyr Arg Ile 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Glu Met Met Ala Lys Glu Glu Glu Leu 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  136

Glu Met Glu Thr Leu Gln Ser Gln Leu 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  137

Glu Leu Cys Ala Glu Ala Glu Glu Leu 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  138

Lys Leu Ala Lys Glu Lys Lys Leu Leu 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  139

Glu Leu Glu Lys Thr Arg Arg Lys Leu 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  140

Lys Leu Glu Gly Asp Ser Thr Asp Leu 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Asp Leu Ser Asp Gln Ile Ala Glu Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  142

Glu Leu Gln Ala Gln Ile Ala Glu Leu 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Gln Leu Ala Lys Lys Glu Glu Glu Leu 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Leu Glu Ser Gln Ile Ser Glu Leu 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  145

Glu Leu Ala Asn Glu Val Lys Val Leu 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  146

Glu Leu Asp Asn Val Thr Gly Leu Leu 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Asn Leu Glu Lys Gln Ile Ala Thr Leu 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  148

Lys Leu Glu Lys Thr Lys Thr Arg Leu 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  149

Arg Leu Gln Gln Glu Leu Asp Asp Leu 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  150

Glu Leu Asp Asp Leu Leu Val Asp Leu 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  151

Asp Leu Met Ser Ser Lys Asp Asp Val 
1               5                   


<210>  152
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  152

Glu Leu Thr Cys Leu Asn Glu Ala Ser Val 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  153

Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile 
1               5                   10  


<210>  154
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  154

Pro Leu Asn Asp Asn Ile Ala Thr Leu Leu 
1               5                   10  


<210>  155
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  155

Glu Leu Val Lys Val Arg Glu Lys Gln Leu 
1               5                   10  


<210>  156
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  156

Lys Leu Lys Lys Leu Glu Glu Glu Gln Ile 
1               5                   10  


<210>  157
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  157

Lys Leu Lys Asn Lys His Glu Ala Met Ile 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  158

Gly Leu Ser Gln Arg His Glu Glu Lys Val 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  159

Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  160

Ala Leu Ala Leu Glu Glu Lys Arg Arg Leu 
1               5                   10  


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  161

Glu Leu Val Glu Asn Gly Lys Lys Val 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  162

Asp Leu Gln Pro Cys Ile Asp Leu Ile 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  163

Glu Leu Trp Lys Asp Val Asp Arg Ile 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Asp Leu Lys Ile Thr Asp Val Ile Ile 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Arg Leu Thr Ala Lys Lys Gln Glu Leu 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  166

Glu Leu Glu Glu Ile Cys His Asp Leu 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  167

Asp Leu Gly Glu Glu Leu Glu Ala Leu 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  168

Glu Leu Glu Ala Leu Lys Thr Glu Leu 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Asn Leu Glu Lys Ala Lys Gln Thr Leu 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Thr Leu Glu Asn Glu Arg Gly Glu Leu 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  171

Gln Leu Leu Ala Glu Glu Lys Thr Ile 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  172

Glu Leu Glu Lys Ser Lys Arg Ala Leu 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  173

Lys Leu Glu Met Asp Leu Lys Asp Leu 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Leu Lys Asp Leu Glu Ala His Ile 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Leu Glu Arg Gln Asn Lys Glu Leu 
1               5                   


<210>  176
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  176

Arg Leu Lys Gln Leu Lys Arg Gln Leu 
1               5                   


<210>  177
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  177

Asn Leu Pro Ile Tyr Ser Glu Glu Ile Val 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  178

Asp Leu Asn Ser Phe Glu Gln Leu Cys Ile 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  179

Gly Leu Asp Leu Gln Pro Cys Ile Asp Leu 
1               5                   10  


<210>  180
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  180

Glu Leu Trp Lys Asp Val Asp Arg Ile Ile 
1               5                   10  


<210>  181
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  181

His Leu Glu Glu Glu Arg Asp Leu Lys Ile 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  182

Asn Met Ala Leu Lys Lys Ile Arg Glu Leu 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  183

Glu Leu Arg Ser Lys Arg Glu Gln Glu Val 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  184

Glu Met Arg Gln Lys His Ser Gln Ala Val 
1               5                   10  


<210>  185
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  185

Asp Met Lys Lys Lys Met Glu Asp Ser Val 
1               5                   10  


<210>  186
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  186

Ala Met Lys Ala Gln Phe Glu Arg Asp Leu 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  187

Ser Met Ala Val Ala Ala Arg Lys Lys Leu 
1               5                   10  


<210>  188
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  188

Val Leu Lys Glu Gly Ser Glu Tyr Arg Val 
1               5                   10  


<210>  189
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  189

His Leu Ser Trp Glu Trp Asn Leu Ser Ile 
1               5                   10  


<210>  190
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  190

Glu Met Asp Lys Asp Asp Glu Ser Leu 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  191

Thr Leu Leu Gly Asp Gly Pro Val Val 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  192

Ala Leu Lys Lys Glu Thr Ile Val Leu 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  193

Ser Leu Ile Lys Tyr Lys Lys Thr Leu 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  194

Asp Leu Thr Gly Asp Leu Glu Ala Leu 
1               5                   


<210>  195
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  195

Glu Met Asp Lys Asp Asp Glu Ser Leu Ile 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  196

Ser Leu Ile Lys Tyr Lys Lys Thr Leu Leu 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  197

Asp Leu Glu Ala Leu Lys Lys Glu Thr Ile 
1               5                   10  


<210>  198
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  198

Asn Leu Ala Glu Asp Ile Met Arg Leu 
1               5                   


<210>  199
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  199

Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val 
1               5                   10  


<210>  200
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  200

Arg Leu Arg Ser Ser Val Pro Gly Val 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  201

Ile Leu Leu Ala Glu Leu Glu Gln Leu 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  202

Ser Leu Gln Glu Glu Ile Ala Phe Leu 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  203

Ala Leu Lys Gly Thr Asn Glu Ser Leu 
1               5                   


<210>  204
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  204

Leu Leu Gln Asp Ser Val Asp Phe Ser Leu 
1               5                   10  


<210>  205
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  205

Ser Leu Pro Leu Pro Asn Phe Ser Ser Leu 
1               5                   10  


<210>  206
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  206

Leu Gln Asp Ser Val Asp Phe Ser Leu 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  207

Ser Leu Thr Cys Glu Val Asp Ala Leu 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  208

His Leu Arg Glu Tyr Gln Asp Leu Leu 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  209

Asp Leu Leu Asn Val Lys Met Ala Leu 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  210

Ser Leu Asn Leu Arg Glu Thr Asn Leu 
1               5                   


<210>  211
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  211

Phe Leu Glu Gln Gln Asn Lys Ile Leu Leu 
1               5                   10  


<210>  212
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  212

Phe Leu Lys Lys Leu His Glu Glu Glu Ile 
1               5                   10  


<210>  213
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  213

Lys Leu His Glu Glu Glu Ile Gln Glu Leu 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  214

Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile 
1               5                   10  


<210>  215
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  215

Phe Leu Glu Gln Gln Asn Lys Ile Leu 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  216

Glu Leu Arg Arg Gln Val Asp Gln Leu 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  217

Thr Leu Gln Ser Phe Arg Gln Asp Val 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  218

Asp Leu Glu Arg Lys Val Glu Ser Leu 
1               5                   


<210>  219
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  219

Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile 
1               5                   10  


<210>  220
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  220

Asn Met Lys Glu Glu Met Ala Arg His Leu 
1               5                   10  


<210>  221
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  221

Leu Leu Asn Val Lys Met Ala Leu Asp Ile 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  222

Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu 
1               5                   10  


<210>  223
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  223

Asp Leu Thr Ala Ala Leu Arg Asp Val 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  224

Leu Leu Glu Gly Glu Glu Ser Arg Ile 
1               5                   


<210>  225
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  225

Ala Leu Arg Pro Ser Thr Ser Arg Ser Leu 
1               5                   10  


<210>  226
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  226

Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu 
1               5                   10  


<210>  227
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  227

Pro Leu Pro Asn Phe Ser Ser Leu Asn Leu 
1               5                   10  


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  228

Glu Met Arg Glu Leu Arg Arg Gln Val 
1               5                   


<210>  229
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  229

Gln Leu Thr Asn Asp Lys Ala Arg Val 
1               5                   


<210>  230
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  230

Gln Leu Lys Gly Gln Gly Lys Ser Arg Leu 
1               5                   10  


<210>  231
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  231

Arg Leu Asn Lys Val Ile Ser Glu Leu 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  232

Phe Met Glu Cys Asn Leu Asn Glu Leu 
1               5                   


<210>  233
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  233

Asn Leu Asn Glu Leu Val Lys His Gly Leu 
1               5                   10  


<210>  234
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  234

His Met Ser Glu Phe Met Glu Cys Asn Leu 
1               5                   10  


<210>  235
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  235

Ile Leu His Val Asp Asn His Ile Gly Ile 
1               5                   10  


<210>  236
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  236

Gly Leu Lys Ser Lys Thr His Ala Val 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  237

Ser Leu Ile Gly Ser Lys Thr Gln Ile 
1               5                   


<210>  238
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  238

Phe Met Glu Cys Asn Leu Asn Glu Leu Val 
1               5                   10  


<210>  239
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  239

Ala Leu Lys Arg Ala Gln Ser Glu Leu 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  240

Gly Leu Thr Ala Asp Ala Arg Leu Leu 
1               5                   


<210>  241
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  241

Pro Leu Pro Val Ser Arg Leu Val Ser Leu 
1               5                   10  


<210>  242
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  242

Asp Leu Thr Thr Lys Asn Val Ser Ile 
1               5                   


<210>  243
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  243

Glu Leu Asn Gly Lys Asn Ile Glu Asp Val 
1               5                   10  


<210>  244
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  244

Glu Leu Ala Ala His Gln Lys Lys Ile 
1               5                   


<210>  245
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  245

Glu Leu Val Lys His Gly Leu Arg Ala Leu 
1               5                   10  


<210>  246
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  246

Gly Leu Lys Ser Lys Thr His Ala Val Leu 
1               5                   10  


<210>  247
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  247

Gly Leu Arg Ala Leu Arg Glu Thr Leu 
1               5                   


<210>  248
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  248

Glu Leu Ala Ala His Gln Lys Lys Ile Leu 
1               5                   10  


<210>  249
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  249

Phe Val Phe Asp Arg Pro Leu Pro Val 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Tyr Val Ala Ser Tyr Leu Leu Ala Ala 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  251

Ile Leu Asp Ser Val Gly Ile Glu Ala 
1               5                   


<210>  252
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  252

Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu 
1               5                   10  


<210>  253
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  253

Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu 
1               5                   10  


<210>  254
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  254

Asp Leu Met Gly Tyr Ile Pro Leu Val 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  255

Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   


<210>  256
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  256

Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr 
1               5                   10  


<210>  257
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  257

Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala 
1               5                   10  


<210>  258
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  258

Leu Leu Ser Cys Leu Thr Thr Pro Ala 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Met Met Asn Trp Ser Pro Thr Thr 
1               5                   


<210>  260
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Met Met Asn Trp Ser Pro Thr Thr Ala 
1               5                   10  


<210>  261
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  261

Tyr Ser Met Ala Gly Asn Trp Ala Lys Val 
1               5                   10  


<210>  262
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  262

Val Leu Ile Val Met Leu Leu Phe Ala 
1               5                   


<210>  263
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  263

Leu Ile Val Met Leu Leu Phe Ala Gly Trp 
1               5                   10  


<210>  264
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  264

Arg Leu Trp His Tyr Pro Cys Thr Val 
1               5                   


<210>  265
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  265

Leu Leu Leu Ser Thr Thr Glu Trp Gln Val 
1               5                   10  


<210>  266
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  266

Leu Leu Ser Thr Thr Glu Trp Gln Val 
1               5                   


<210>  267
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  267

Tyr Leu Tyr Gly Ile Gly Ser Ala Val 
1               5                   


<210>  268
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  268

Tyr Leu Tyr Gly Ile Gly Ser Ala Val Val 
1               5                   10  


<210>  269
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  269

Tyr Val Leu Leu Leu Phe Leu Leu Leu Ala 
1               5                   10  


<210>  270
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  270

Val Leu Leu Leu Phe Leu Leu Leu Ala 
1               5                   


<210>  271
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  271

Phe Leu Leu Leu Ala Asp Ala Arg Val 
1               5                   


<210>  272
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  272

Trp Met Met Leu Leu Ile Ala Gln Ala 
1               5                   


<210>  273
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Leu Leu Ile Ala Gln Ala Glu Ala 
1               5                   


<210>  274
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  274

Phe Leu Ala Arg Leu Ile Trp Trp Leu 
1               5                   


<210>  275
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  275

Leu Leu Met Cys Ala Val His Pro Glu Leu 
1               5                   10  


<210>  276
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  276

Lys Leu Leu Ile Ala Ile Leu Gly Pro Leu 
1               5                   10  


<210>  277
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  277

Leu Leu Ile Ala Ile Leu Gly Pro Leu 
1               5                   


<210>  278
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  278

Val Leu Gln Ala Gly Ile Thr Arg Val 
1               5                   


<210>  279
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  279

Gly Leu Ile His Ala Cys Met Leu Val 
1               5                   


<210>  280
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  280

Lys Leu Gly Ala Leu Thr Gly Tyr Ile 
1               5                   


<210>  281
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  281

Tyr Ile Tyr Asn His Leu Thr Pro Leu 
1               5                   


<210>  282
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  282

Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu 
1               5                   10  


<210>  283
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  283

Leu Leu Gly Cys Ile Ile Thr Ser Leu 
1               5                   


<210>  284
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  284

Phe Leu Ala Thr Cys Val Asn Gly Val 
1               5                   


<210>  285
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  285

Lys Leu Ser Gly Leu Gly Ile Asn Ala Val 
1               5                   10  


<210>  286
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  286

Tyr Leu Asn Thr Pro Gly Leu Pro Val 
1               5                   


<210>  287
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  287

Tyr Leu Val Ala Tyr Gln Ala Thr Val 
1               5                   


<210>  288
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  288

Gln Met Trp Lys Cys Leu Ile Arg Leu 
1               5                   


<210>  289
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  289

Val Leu Val Gly Gly Val Leu Ala Ala Leu 
1               5                   10  


<210>  290
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  290

His Met Trp Asn Phe Ile Ser Gly Ile 
1               5                   


<210>  291
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  291

Phe Ile Ser Gly Ile Gln Tyr Leu Ala 
1               5                   


<210>  292
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  292

Ser Leu Met Ala Phe Thr Ala Ser Ile 
1               5                   


<210>  293
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  293

Leu Leu Phe Asn Ile Leu Gly Gly Trp Val 
1               5                   10  


<210>  294
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  294

Ile Leu Ala Gly Tyr Gly Ala Gly Val 
1               5                   


<210>  295
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  295

Lys Leu Leu Pro Gln Leu Pro Gly Val 
1               5                   


<210>  296
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  296

Arg Leu Ile Val Phe Pro Asp Leu Gly Val 
1               5                   10  


<210>  297
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  297

Ala Leu Tyr Asp Val Val Ser Thr Leu 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  298

Lys Leu Gln Asp Cys Thr Met Leu Val 
1               5                   


<210>  299
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Leu Val Asn Gly Asp Asp Leu Val Val 
1               5                   10  


<210>  300
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  300

Trp Leu Gly Asn Ile Ile Met Tyr Ala 
1               5                   


<210>  301
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ile Leu Met Thr His Phe Phe Ser Ile 
1               5                   10  


<210>  302
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  302

Ile Leu Met Thr His Phe Phe Ser Ile 
1               5                   


<210>  303
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  303

Ile Leu Met Thr His Phe Phe Ser Ile Leu 
1               5                   10  


<210>  304
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  304

Ala Leu Asp Cys Gln Ile Tyr Gly Ala 
1               5                   


<210>  305
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  305

Arg Leu His Gly Leu Ser Ala Phe Ser Leu 
1               5                   10  


<210>  306
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  306

Phe Met Leu Cys Leu Leu Leu Leu Ser 
1               5                   


<210>  307
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  307

Phe Met Leu Cys Leu Leu Leu Leu Ser Val 
1               5                   10  


<210>  308
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Leu Cys Leu Leu Leu Leu Ser Val 
1               5                   


<210>  309
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  309

Leu Leu Leu Leu Ser Val Gly Val Gly Ile 
1               5                   10  


<210>  310
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  310

Leu Leu Ser Val Gly Val Gly Ile Tyr Leu 
1               5                   10  


<210>  311
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  311

Phe Leu Leu Ala Leu Leu Ser Cys Ile 
1               5                   


<210>  312
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  312

Leu Leu Ala Leu Leu Ser Cys Ile Ser Val 
1               5                   10  


<210>  313
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  313

Ala Leu Leu Ser Cys Ile Ser Val Pro Val 
1               5                   10  


<210>  314
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  314

Leu Leu Ser Cys Ile Ser Val Pro Val 
1               5                   


<210>  315
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  315

Ala Leu Met Ile Ala Ala Gln Val Val Val 
1               5                   10  


<210>  316
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Leu Leu Ala Tyr Leu Val Arg Ile 
1               5                   


<210>  317
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  317

Val Met Phe Gly Leu Ala Tyr Phe Ser Met 
1               5                   10  


<210>  318
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  318

Phe Ser Met Gln Gly Ala Trp Ala Lys Val 
1               5                   10  


<210>  319
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  319

His Leu Phe Thr Ser Met Phe Ser Leu 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  320

Phe Leu Ala Ala Leu Phe Tyr Thr Ser 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  321

Tyr Leu Tyr Gly Leu Ser Pro Ala Ile 
1               5                   


<210>  322
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  322

Gly Leu Leu Tyr Phe Ile Leu Phe Phe Val 
1               5                   10  


<210>  323
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  323

Leu Leu Tyr Phe Ile Leu Phe Phe Val 
1               5                   


<210>  324
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  324

Leu Leu Tyr Phe Ile Leu Phe Phe Val Ala 
1               5                   10  


<210>  325
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  325

Tyr Thr Leu Leu Gly Cys Trp Ser Phe Val 
1               5                   10  


<210>  326
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  326

Thr Leu Leu Gly Cys Trp Ser Phe Val 
1               5                   


<210>  327
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  327

Thr Leu Leu Gly Cys Trp Ser Phe Val Leu 
1               5                   10  


<210>  328
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  328

Leu Leu Met Ala Leu Pro His Gln Ala 
1               5                   


<210>  329
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  329

Leu Leu Ile Ala Ile Thr Ala Phe 
1               5               


<210>  330
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  330

Ile Leu Leu Ser Arg Cys Leu Trp Trp Thr 
1               5                   10  


<210>  331
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  331

Cys Leu Trp Trp Thr Cys Tyr Met Leu Val 
1               5                   10  


<210>  332
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  332

Tyr Met Leu Val Leu Ala Glu Ala Leu Ile 
1               5                   10  


<210>  333
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  333

Leu Ile Gln Asp Trp Ile Pro Pro Leu 
1               5                   


<210>  334
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  334

Ala Met Thr Met Phe Tyr Pro Gly Val 
1               5                   


<210>  335
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  335

Ala Leu Leu Arg Met Cys Ala Leu Val 
1               5                   


<210>  336
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  336

Arg Leu Leu Ala Pro Ile Thr Ala Tyr Ala 
1               5                   10  


<210>  337
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  337

Leu Leu Ala Pro Ile Thr Ala Tyr Ala 
1               5                   


<210>  338
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  338

Phe Leu Gly Thr Ser Ile Ser Gly Val 
1               5                   


<210>  339
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  339

Thr Ser Ile Ser Gly Val Leu Trp Thr Val 
1               5                   10  


<210>  340
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  340

Ser Ile Ser Gly Val Leu Trp Thr Val 
1               5                   


<210>  341
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  341

Val Leu Trp Thr Val Phe His Gly Ala 
1               5                   


<210>  342
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  342

Tyr Leu Val Thr Arg Asn Ala Asp Val 
1               5                   


<210>  343
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  343

Val Met Trp Lys Cys Leu Ile Arg Leu 
1               5                   


<210>  344
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  344

Val Leu Ala Gly Gly Val Leu Ala Ala Val 
1               5                   10  


<210>  345
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  345

Ser Met Met Ser Phe Ser Ala Ala Leu 
1               5                   


<210>  346
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  346

Val Leu Ala Gly Tyr Gly Ala Gly Ile 
1               5                   


<210>  347
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  347

Lys Ile Met Ser Gly Glu Lys Pro Ser Val 
1               5                   10  


<210>  348
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  348

Lys Leu Phe Pro Arg Leu Pro Gly Ile 
1               5                   


<210>  349
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  349

Phe Met Arg Asp Glu Val Ser Phe Ser Val 
1               5                   10  


<210>  350
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  350

Val Leu Met Val Asp Ser Phe Asp Pro Val 
1               5                   10  


<210>  351
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  351

Leu Met Val Asp Ser Phe Asp Pro Val 
1               5                   


<210>  352
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  352

Leu Leu Asp Ser His Tyr Glu Ser Val 
1               5                   


<210>  353
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  353

Arg Leu Ile Val Tyr Pro Asp Leu Gly Val 
1               5                   10  


<210>  354
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  354

Ser Met Gly Asn Thr Leu Thr Cys Tyr Val 
1               5                   10  


<210>  355
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Leu Val Cys Gly Asp Asp Leu Val Val 
1               5                   10  


<210>  356
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Val Leu Met Thr His Phe Phe Ser Val 
1               5                   10  


<210>  357
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  357

Val Leu Met Thr His Phe Phe Ser Val 
1               5                   


<210>  358
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  358

Val Leu Met Thr His Phe Phe Ser Val Leu 
1               5                   10  


<210>  359
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  359

Arg Leu His Gly Leu Glu Ala Phe Ser Leu 
1               5                   10  


<210>  360
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  360

Arg Leu Leu Asp Leu Ser Ser Trp Phe Thr 
1               5                   10  


<210>  361
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  361

Arg Leu Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10  


<210>  362
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  362

Leu Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   


<210>  363
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  363

Leu Leu Leu Gly Leu Leu Leu Leu Cys Val 
1               5                   10  


<210>  364
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  364

Leu Leu Gly Leu Leu Leu Leu Cys Val 
1               5                   


<210>  365
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  365

Gly Leu Leu Leu Leu Cys Val Gly Val 
1               5                   


<210>  366
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  367
<211>  1960
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Ala Gln Gln Ala Ala Asp Lys Tyr Leu Tyr Val Asp Lys Asn Phe 
1               5                   10                  15      


Ile Asn Asn Pro Leu Ala Gln Ala Asp Trp Ala Ala Lys Lys Leu Val 
            20                  25                  30          


Trp Val Pro Ser Asp Lys Ser Gly Phe Glu Pro Ala Ser Leu Lys Glu 
        35                  40                  45              


Glu Val Gly Glu Glu Ala Ile Val Glu Leu Val Glu Asn Gly Lys Lys 
    50                  55                  60                  


Val Lys Val Asn Lys Asp Asp Ile Gln Lys Met Asn Pro Pro Lys Phe 
65                  70                  75                  80  


Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu Asn Glu Ala Ser 
                85                  90                  95      


Val Leu His Asn Leu Lys Glu Arg Tyr Tyr Ser Gly Leu Ile Tyr Thr 
            100                 105                 110         


Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr Lys Asn Leu Pro 
        115                 120                 125             


Ile Tyr Ser Glu Glu Ile Val Glu Met Tyr Lys Gly Lys Lys Arg His 
    130                 135                 140                 


Glu Met Pro Pro His Ile Tyr Ala Ile Thr Asp Thr Ala Tyr Arg Ser 
145                 150                 155                 160 


Met Met Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys Thr Gly Glu Ser 
                165                 170                 175     


Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile Gln Tyr Leu Ala 
            180                 185                 190         


Tyr Val Ala Ser Ser His Lys Ser Lys Lys Asp Gln Gly Glu Leu Glu 
        195                 200                 205             


Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala 
    210                 215                 220                 


Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg 
225                 230                 235                 240 


Ile Asn Phe Asp Val Asn Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr 
                245                 250                 255     


Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys Glu Glu Arg 
            260                 265                 270         


Thr Phe His Ile Phe Tyr Tyr Leu Leu Ser Gly Ala Gly Glu His Leu 
        275                 280                 285             


Lys Thr Asp Leu Leu Leu Glu Pro Tyr Asn Lys Tyr Arg Phe Leu Ser 
    290                 295                 300                 


Asn Gly His Val Thr Ile Pro Gly Gln Gln Asp Lys Asp Met Phe Gln 
305                 310                 315                 320 


Glu Thr Met Glu Ala Met Arg Ile Met Gly Ile Pro Glu Glu Glu Gln 
                325                 330                 335     


Met Gly Leu Leu Arg Val Ile Ser Gly Val Leu Gln Leu Gly Asn Ile 
            340                 345                 350         


Val Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn 
        355                 360                 365             


Thr Ala Ala Gln Lys Val Ser His Leu Leu Gly Ile Asn Val Thr Asp 
    370                 375                 380                 


Phe Thr Arg Gly Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Tyr 
385                 390                 395                 400 


Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Ile Glu Ala 
                405                 410                 415     


Leu Ala Lys Ala Thr Tyr Glu Arg Met Phe Arg Trp Leu Val Leu Arg 
            420                 425                 430         


Ile Asn Lys Ala Leu Asp Lys Thr Lys Arg Gln Gly Ala Ser Phe Ile 
        435                 440                 445             


Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Asp Leu Asn Ser Phe 
    450                 455                 460                 


Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe 
465                 470                 475                 480 


Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly 
                485                 490                 495     


Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile 
            500                 505                 510         


Asp Leu Ile Glu Lys Pro Ala Gly Pro Pro Gly Ile Leu Ala Leu Leu 
        515                 520                 525             


Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu 
    530                 535                 540                 


Lys Val Met Gln Glu Gln Gly Thr His Pro Lys Phe Gln Lys Pro Lys 
545                 550                 555                 560 


Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly Lys 
                565                 570                 575     


Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro Leu 
            580                 585                 590         


Asn Asp Asn Ile Ala Thr Leu Leu His Gln Ser Ser Asp Lys Phe Val 
        595                 600                 605             


Ser Glu Leu Trp Lys Asp Val Asp Arg Ile Ile Gly Leu Asp Gln Val 
    610                 615                 620                 


Ala Gly Met Ser Glu Thr Ala Leu Pro Gly Ala Phe Lys Thr Arg Lys 
625                 630                 635                 640 


Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Ala Lys 
                645                 650                 655     


Leu Met Ala Thr Leu Arg Asn Thr Asn Pro Asn Phe Val Arg Cys Ile 
            660                 665                 670         


Ile Pro Asn His Glu Lys Lys Ala Gly Lys Leu Asp Pro His Leu Val 
        675                 680                 685             


Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys 
    690                 695                 700                 


Arg Gln Gly Phe Pro Asn Arg Val Val Phe Gln Glu Phe Arg Gln Arg 
705                 710                 715                 720 


Tyr Glu Ile Leu Thr Pro Asn Ser Ile Pro Lys Gly Phe Met Asp Gly 
                725                 730                 735     


Lys Gln Ala Cys Val Leu Met Ile Lys Ala Leu Glu Leu Asp Ser Asn 
            740                 745                 750         


Leu Tyr Arg Ile Gly Gln Ser Lys Val Phe Phe Arg Ala Gly Val Leu 
        755                 760                 765             


Ala His Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Ile 
    770                 775                 780                 


Gly Phe Gln Ala Cys Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala 
785                 790                 795                 800 


Lys Arg Gln Gln Gln Leu Thr Ala Met Lys Val Leu Gln Arg Asn Cys 
                805                 810                 815     


Ala Ala Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr 
            820                 825                 830         


Lys Val Lys Pro Leu Leu Gln Val Ser Arg Gln Glu Glu Glu Met Met 
        835                 840                 845             


Ala Lys Glu Glu Glu Leu Val Lys Val Arg Glu Lys Gln Leu Ala Ala 
    850                 855                 860                 


Glu Asn Arg Leu Thr Glu Met Glu Thr Leu Gln Ser Gln Leu Met Ala 
865                 870                 875                 880 


Glu Lys Leu Gln Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Cys 
                885                 890                 895     


Ala Glu Ala Glu Glu Leu Arg Ala Arg Leu Thr Ala Lys Lys Gln Glu 
            900                 905                 910         


Leu Glu Glu Ile Cys His Asp Leu Glu Ala Arg Val Glu Glu Glu Glu 
        915                 920                 925             


Glu Arg Cys Gln His Leu Gln Ala Glu Lys Lys Lys Met Gln Gln Asn 
    930                 935                 940                 


Ile Gln Glu Leu Glu Glu Gln Leu Glu Glu Glu Glu Ser Ala Arg Gln 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Val Thr Thr Glu Ala Lys Leu Lys Lys Leu 
                965                 970                 975     


Glu Glu Glu Gln Ile Ile Leu Glu Asp Gln Asn Cys Lys Leu Ala Lys 
            980                 985                 990         


Glu Lys Lys Leu Leu Glu Asp Arg  Ile Ala Glu Phe Thr  Thr Asn Leu 
        995                 1000                 1005             


Thr Glu  Glu Glu Glu Lys Ser  Lys Ser Leu Ala Lys  Leu Lys Asn 
    1010                 1015                 1020             


Lys His  Glu Ala Met Ile Thr  Asp Leu Glu Glu Arg  Leu Arg Arg 
    1025                 1030                 1035             


Glu Glu  Lys Gln Arg Gln Glu  Leu Glu Lys Thr Arg  Arg Lys Leu 
    1040                 1045                 1050             


Glu Gly  Asp Ser Thr Asp Leu  Ser Asp Gln Ile Ala  Glu Leu Gln 
    1055                 1060                 1065             


Ala Gln  Ile Ala Glu Leu Lys  Met Gln Leu Ala Lys  Lys Glu Glu 
    1070                 1075                 1080             


Glu Leu  Gln Ala Ala Leu Ala  Arg Val Glu Glu Glu  Ala Ala Gln 
    1085                 1090                 1095             


Lys Asn  Met Ala Leu Lys Lys  Ile Arg Glu Leu Glu  Ser Gln Ile 
    1100                 1105                 1110             


Ser Glu  Leu Gln Glu Asp Leu  Glu Ser Glu Arg Ala  Ser Arg Asn 
    1115                 1120                 1125             


Lys Ala  Glu Lys Gln Lys Arg  Asp Leu Gly Glu Glu  Leu Glu Ala 
    1130                 1135                 1140             


Leu Lys  Thr Glu Leu Glu Asp  Thr Leu Asp Ser Thr  Ala Ala Gln 
    1145                 1150                 1155             


Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu Val Asn  Ile Leu Lys 
    1160                 1165                 1170             


Lys Thr  Leu Glu Glu Glu Ala  Lys Thr His Glu Ala  Gln Ile Gln 
    1175                 1180                 1185             


Glu Met  Arg Gln Lys His Ser  Gln Ala Val Glu Glu  Leu Ala Glu 
    1190                 1195                 1200             


Gln Leu  Glu Gln Thr Lys Arg  Val Lys Ala Asn Leu  Glu Lys Ala 
    1205                 1210                 1215             


Lys Gln  Thr Leu Glu Asn Glu  Arg Gly Glu Leu Ala  Asn Glu Val 
    1220                 1225                 1230             


Lys Val  Leu Leu Gln Gly Lys  Gly Asp Ser Glu His  Lys Arg Lys 
    1235                 1240                 1245             


Lys Val  Glu Ala Gln Leu Gln  Glu Leu Gln Val Lys  Phe Asn Glu 
    1250                 1255                 1260             


Gly Glu  Arg Val Arg Thr Glu  Leu Ala Asp Lys Val  Thr Lys Leu 
    1265                 1270                 1275             


Gln Val  Glu Leu Asp Asn Val  Thr Gly Leu Leu Ser  Gln Ser Asp 
    1280                 1285                 1290             


Ser Lys  Ser Ser Lys Leu Thr  Lys Asp Phe Ser Ala  Leu Glu Ser 
    1295                 1300                 1305             


Gln Leu  Gln Asp Thr Gln Glu  Leu Leu Gln Glu Glu  Asn Arg Gln 
    1310                 1315                 1320             


Lys Leu  Ser Leu Ser Thr Lys  Leu Lys Gln Val Glu  Asp Glu Lys 
    1325                 1330                 1335             


Asn Ser  Phe Arg Glu Gln Leu  Glu Glu Glu Glu Glu  Ala Lys His 
    1340                 1345                 1350             


Asn Leu  Glu Lys Gln Ile Ala  Thr Leu His Ala Gln  Val Ala Asp 
    1355                 1360                 1365             


Met Lys  Lys Lys Met Glu Asp  Ser Val Gly Cys Leu  Glu Thr Ala 
    1370                 1375                 1380             


Glu Glu  Val Lys Arg Lys Leu  Gln Lys Asp Leu Glu  Gly Leu Ser 
    1385                 1390                 1395             


Gln Arg  His Glu Glu Lys Val  Ala Ala Tyr Asp Lys  Leu Glu Lys 
    1400                 1405                 1410             


Thr Lys  Thr Arg Leu Gln Gln  Glu Leu Asp Asp Leu  Leu Val Asp 
    1415                 1420                 1425             


Leu Asp  His Gln Arg Gln Ser  Ala Cys Asn Leu Glu  Lys Lys Gln 
    1430                 1435                 1440             


Lys Lys  Phe Asp Gln Leu Leu  Ala Glu Glu Lys Thr  Ile Ser Ala 
    1445                 1450                 1455             


Lys Tyr  Ala Glu Glu Arg Asp  Arg Ala Glu Ala Glu  Ala Arg Glu 
    1460                 1465                 1470             


Lys Glu  Thr Lys Ala Leu Ser  Leu Ala Arg Ala Leu  Glu Glu Ala 
    1475                 1480                 1485             


Met Glu  Gln Lys Ala Glu Leu  Glu Arg Leu Asn Lys  Gln Phe Arg 
    1490                 1495                 1500             


Thr Glu  Met Glu Asp Leu Met  Ser Ser Lys Asp Asp  Val Gly Lys 
    1505                 1510                 1515             


Ser Val  His Glu Leu Glu Lys  Ser Lys Arg Ala Leu  Glu Gln Gln 
    1520                 1525                 1530             


Val Glu  Glu Met Lys Thr Gln  Leu Glu Glu Leu Glu  Asp Glu Leu 
    1535                 1540                 1545             


Gln Ala  Thr Glu Asp Ala Lys  Leu Arg Leu Glu Val  Asn Leu Gln 
    1550                 1555                 1560             


Ala Met  Lys Ala Gln Phe Glu  Arg Asp Leu Gln Gly  Arg Asp Glu 
    1565                 1570                 1575             


Gln Ser  Glu Glu Lys Lys Lys  Gln Leu Val Arg Gln  Val Arg Glu 
    1580                 1585                 1590             


Met Glu  Ala Glu Leu Glu Asp  Glu Arg Lys Gln Arg  Ser Met Ala 
    1595                 1600                 1605             


Val Ala  Ala Arg Lys Lys Leu  Glu Met Asp Leu Lys  Asp Leu Glu 
    1610                 1615                 1620             


Ala His  Ile Asp Ser Ala Asn  Lys Asn Arg Asp Glu  Ala Ile Lys 
    1625                 1630                 1635             


Gln Leu  Arg Lys Leu Gln Ala  Gln Met Lys Asp Cys  Met Arg Glu 
    1640                 1645                 1650             


Leu Asp  Asp Thr Arg Ala Ser  Arg Glu Glu Ile Leu  Ala Gln Ala 
    1655                 1660                 1665             


Lys Glu  Asn Glu Lys Lys Leu  Lys Ser Met Glu Ala  Glu Met Ile 
    1670                 1675                 1680             


Gln Leu  Gln Glu Glu Leu Ala  Ala Ala Glu Arg Ala  Lys Arg Gln 
    1685                 1690                 1695             


Ala Gln  Gln Glu Arg Asp Glu  Leu Ala Asp Glu Ile  Ala Asn Ser 
    1700                 1705                 1710             


Ser Gly  Lys Gly Ala Leu Ala  Leu Glu Glu Lys Arg  Arg Leu Glu 
    1715                 1720                 1725             


Ala Arg  Ile Ala Gln Leu Glu  Glu Glu Leu Glu Glu  Glu Gln Gly 
    1730                 1735                 1740             


Asn Thr  Glu Leu Ile Asn Asp  Arg Leu Lys Lys Ala  Asn Leu Gln 
    1745                 1750                 1755             


Ile Asp  Gln Ile Asn Thr Asp  Leu Asn Leu Glu Arg  Ser His Ala 
    1760                 1765                 1770             


Gln Lys  Asn Glu Asn Ala Arg  Gln Gln Leu Glu Arg  Gln Asn Lys 
    1775                 1780                 1785             


Glu Leu  Lys Val Lys Leu Gln  Glu Met Glu Gly Thr  Val Lys Ser 
    1790                 1795                 1800             


Lys Tyr  Lys Ala Ser Ile Thr  Ala Leu Glu Ala Lys  Ile Ala Gln 
    1805                 1810                 1815             


Leu Glu  Glu Gln Leu Asp Asn  Glu Thr Lys Glu Arg  Gln Ala Ala 
    1820                 1825                 1830             


Cys Lys  Gln Val Arg Arg Thr  Glu Lys Lys Leu Lys  Asp Val Leu 
    1835                 1840                 1845             


Leu Gln  Val Asp Asp Glu Arg  Arg Asn Ala Glu Gln  Tyr Lys Asp 
    1850                 1855                 1860             


Gln Ala  Asp Lys Ala Ser Thr  Arg Leu Lys Gln Leu  Lys Arg Gln 
    1865                 1870                 1875             


Leu Glu  Glu Ala Glu Glu Glu  Ala Gln Arg Ala Asn  Ala Ser Arg 
    1880                 1885                 1890             


Arg Lys  Leu Gln Arg Glu Leu  Glu Asp Ala Thr Glu  Thr Ala Asp 
    1895                 1900                 1905             


Ala Met  Asn Arg Glu Val Ser  Ser Leu Lys Asn Lys  Leu Arg Arg 
    1910                 1915                 1920             


Gly Asp  Leu Pro Phe Val Val  Pro Arg Arg Met Ala  Arg Lys Gly 
    1925                 1930                 1935             


Ala Gly  Asp Gly Ser Asp Glu  Glu Val Asp Gly Lys  Ala Asp Gly 
    1940                 1945                 1950             


Ala Glu  Ala Lys Pro Ala Glu  
    1955                 1960 


<210>  368
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Ala Thr Ala Thr Pro Val Pro Pro Arg Met Gly Ser Arg Ala Gly 
1               5                   10                  15      


Gly Pro Thr Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu 
            20                  25                  30          


Lys Glu Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp 
        35                  40                  45              


Lys Val Arg Ser Leu Glu Thr Glu Asn Ser Ala Leu Gln Leu Gln Val 
    50                  55                  60                  


Thr Glu Arg Glu Glu Val Arg Gly Arg Glu Leu Thr Gly Leu Lys Ala 
65                  70                  75                  80  


Leu Tyr Glu Thr Glu Leu Ala Asp Ala Arg Arg Ala Leu Asp Asp Thr 
                85                  90                  95      


Ala Arg Glu Arg Ala Lys Leu Gln Ile Glu Leu Gly Lys Cys Lys Ala 
            100                 105                 110         


Glu His Asp Gln Leu Leu Leu Asn Tyr Ala Lys Lys Glu Ser Asp Leu 
        115                 120                 125             


Asn Gly Ala Gln Ile Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser 
    130                 135                 140                 


Lys Asp Ala Ala Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu 
145                 150                 155                 160 


Gly Asp Leu Glu Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser 
                165                 170                 175     


Leu Ala Ala Ala Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val 
            180                 185                 190         


Asp Leu Glu Asn Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg 
        195                 200                 205             


Lys Ser Met Tyr Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu 
    210                 215                 220                 


Thr Arg Leu Val Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr 
225                 230                 235                 240 


Lys Leu Ala Gln Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln 
                245                 250                 255     


Val Arg Leu Tyr Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu 
            260                 265                 270         


Glu Asn Ala Arg Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser 
        275                 280                 285             


Ala Arg Glu Glu Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser 
    290                 295                 300                 


Ser Gln Leu Ser Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Arg 
305                 310                 315                 320 


Ile Gln Glu Leu Glu Asp Leu Leu Ala Lys Glu Lys Asp Asn Ser Arg 
                325                 330                 335     


Arg Met Leu Thr Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln 
            340                 345                 350         


Met Gln Gln Gln Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu 
        355                 360                 365             


Ala Leu Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu 
    370                 375                 380                 


Glu Glu Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val 
385                 390                 395                 400 


Ser Arg Ala Ser Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg 
                405                 410                 415     


Lys Arg Val Asp Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile 
            420                 425                 430         


Ser His Ser Ala Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp 
        435                 440                 445             


Val Asp Gly Lys Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln 
    450                 455                 460                 


Pro Met Gly Gly Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val 
465                 470                 475                 480 


Ser Tyr Lys Tyr Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val 
                485                 490                 495     


Thr Ile Trp Ala Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp 
            500                 505                 510         


Leu Ile Trp Lys Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys 
        515                 520                 525             


Val Ile Leu Lys Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr 
    530                 535                 540                 


Val Phe Lys Thr Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Ala 
545                 550                 555                 560 


Ala Gly Val Val Val Glu Glu Glu Leu Phe His Gln Gln Gly Thr Pro 
                565                 570                 575     


Arg Ala Ser Asn Arg Ser Cys Ala Ile Met 
            580                 585     


<210>  369
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Thr Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Thr Leu Leu Gly Asp Gly Pro Val Val Thr Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Thr Arg Leu Thr Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Thr Met Asp Leu Thr Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Thr Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His 
        115                 120                 125             


Thr Tyr Arg Thr Gly Val Lys Val Asp Lys Ala Thr Phe Met Val Gly 
    130                 135                 140                 


Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Thr Pro Val Glu 
145                 150                 155                 160 


Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Thr Tyr His Asn Lys Ser 
                165                 170                 175     


Phe Phe Thr Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn 
            180                 185                 190         


Leu Ser Ile Lys Lys Glu Trp Thr Glu 
        195                 200     


<210>  370
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  371
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  372
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ala Ala Tyr Lys Leu Val Leu Ile Arg His Gly Glu Ser Ala Trp 
1               5                   10                  15      


Asn Leu Glu Asn Arg Phe Ser Gly Trp Tyr Asp Ala Asp Leu Ser Pro 
            20                  25                  30          


Ala Gly His Glu Glu Ala Lys Arg Gly Gly Gln Ala Leu Arg Asp Ala 
        35                  40                  45              


Gly Tyr Glu Phe Asp Ile Cys Phe Thr Ser Val Gln Lys Arg Ala Ile 
    50                  55                  60                  


Arg Thr Leu Trp Thr Val Leu Asp Ala Ile Asp Gln Met Trp Leu Pro 
65                  70                  75                  80  


Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr 
                85                  90                  95      


Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Ala Gln Val 
            100                 105                 110         


Lys Ile Trp Arg Arg Ser Tyr Asp Val Pro Pro Pro Pro Met Glu Pro 
        115                 120                 125             


Asp His Pro Phe Tyr Ser Asn Ile Ser Lys Asp Arg Arg Tyr Ala Asp 
    130                 135                 140                 


Leu Thr Glu Asp Gln Leu Pro Ser Cys Glu Ser Leu Lys Asp Thr Ile 
145                 150                 155                 160 


Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys 
                165                 170                 175     


Glu Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly 
            180                 185                 190         


Ile Val Lys His Leu Glu Gly Leu Ser Glu Glu Ala Ile Met Glu Leu 
        195                 200                 205             


Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asp Lys Asn Leu 
    210                 215                 220                 


Lys Pro Ile Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg 
225                 230                 235                 240 


Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys Lys 
                245                 250                 


<210>  373
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Ala Leu Pro Phe Arg Lys Asp Leu Glu Lys Tyr Lys Asp Leu Asp 
1               5                   10                  15      


Glu Asp Glu Leu Leu Gly Asn Leu Ser Glu Thr Glu Leu Lys Gln Leu 
            20                  25                  30          


Glu Thr Val Leu Asp Asp Leu Asp Pro Glu Asn Ala Leu Leu Pro Ala 
        35                  40                  45              


Gly Phe Arg Gln Lys Asn Gln Thr Ser Lys Ser Thr Thr Gly Pro Phe 
    50                  55                  60                  


Asp Arg Glu His Leu Leu Ser Tyr Leu Glu Lys Glu Ala Leu Glu His 
65                  70                  75                  80  


Lys Asp Arg Glu Asp Tyr Val Pro Tyr Thr Gly Glu Lys Lys Gly Lys 
                85                  90                  95      


Ile Phe Ile Pro Lys Gln Lys Pro Val Gln Thr Phe Thr Glu Glu Lys 
            100                 105                 110         


Val Ser Leu Asp Pro Glu Leu Glu Glu Ala Leu Thr Ser Ala Ser Asp 
        115                 120                 125             


Thr Glu Leu Cys Asp Leu Ala Ala Ile Leu Gly Met His Asn Leu Ile 
    130                 135                 140                 


Thr Asn Thr Lys Phe Cys Asn Ile Met Gly Ser Ser Asn Gly Val Asp 
145                 150                 155                 160 


Gln Glu His Phe Ser Asn Val Val Lys Gly Glu Lys Ile Leu Pro Val 
                165                 170                 175     


Phe Asp Glu Pro Pro Asn Pro Thr Asn Val Glu Glu Ser Leu Lys Arg 
            180                 185                 190         


Thr Lys Glu Asn Asp Ala His Leu Val Glu Val Asn Leu Asn Asn Ile 
        195                 200                 205             


Lys Asn Ile Pro Ile Pro Thr Leu Lys Asp Phe Ala Lys Ala Leu Glu 
    210                 215                 220                 


Thr Asn Thr His Val Lys Cys Phe Ser Leu Ala Ala Thr Arg Ser Asn 
225                 230                 235                 240 


Asp Pro Val Ala Thr Ala Phe Ala Glu Met Leu Lys Val Asn Lys Thr 
                245                 250                 255     


Leu Lys Ser Leu Asn Val Glu Ser Asn Phe Ile Thr Gly Val Gly Ile 
            260                 265                 270         


Leu Ala Leu Ile Asp Ala Leu Arg Asp Asn Glu Thr Leu Ala Glu Leu 
        275                 280                 285             


Lys Ile Asp Asn Gln Arg Gln Gln Leu Gly Thr Ala Val Glu Leu Glu 
    290                 295                 300                 


Met Ala Lys Met Leu Glu Glu Asn Thr Asn Ile Leu Lys Phe Gly Tyr 
305                 310                 315                 320 


Gln Phe Thr Gln Gln Gly Pro Arg Thr Arg Ala Ala Asn Ala Ile Thr 
                325                 330                 335     


Lys Asn Asn Asp Leu Val Arg Lys Arg Arg Val Glu Gly Asp His Gln 
            340                 345                 350         


<210>  374
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Ala Met Arg Gln Thr Pro Leu Thr Cys Ser Gly His Thr Arg Pro 
1               5                   10                  15      


Val Val Asp Leu Ala Phe Ser Gly Ile Thr Pro Tyr Gly Tyr Phe Leu 
            20                  25                  30          


Ile Ser Ala Cys Lys Asp Gly Lys Pro Met Leu Arg Gln Gly Asp Thr 
        35                  40                  45              


Gly Asp Trp Ile Gly Thr Phe Leu Gly His Lys Gly Ala Val Trp Gly 
    50                  55                  60                  


Ala Thr Leu Asn Lys Asp Ala Thr Lys Ala Ala Thr Ala Ala Ala Asp 
65                  70                  75                  80  


Phe Thr Ala Lys Val Trp Asp Ala Val Ser Gly Asp Glu Leu Met Thr 
                85                  90                  95      


Leu Ala His Lys His Ile Val Lys Thr Val Asp Phe Thr Gln Asp Ser 
            100                 105                 110         


Asn Tyr Leu Leu Thr Gly Gly Gln Asp Lys Leu Leu Arg Ile Tyr Asp 
        115                 120                 125             


Leu Asn Lys Pro Glu Ala Glu Pro Lys Glu Ile Ser Gly His Thr Ser 
    130                 135                 140                 


Gly Ile Lys Lys Ala Leu Trp Cys Ser Glu Asp Lys Gln Ile Leu Ser 
145                 150                 155                 160 


Ala Asp Asp Lys Thr Val Arg Leu Trp Asp His Ala Thr Met Thr Glu 
                165                 170                 175     


Val Lys Ser Leu Asn Phe Asn Met Ser Val Ser Ser Met Glu Tyr Ile 
            180                 185                 190         


Pro Glu Gly Glu Ile Leu Val Ile Thr Tyr Gly Arg Ser Ile Ala Phe 
        195                 200                 205             


His Ser Ala Val Ser Leu Asp Pro Ile Lys Ser Phe Glu Ala Pro Ala 
    210                 215                 220                 


Thr Ile Asn Ser Ala Ser Leu His Pro Glu Lys Glu Phe Leu Val Ala 
225                 230                 235                 240 


Gly Gly Glu Asp Phe Lys Leu Tyr Lys Tyr Asp Tyr Asn Ser Gly Glu 
                245                 250                 255     


Glu Leu Glu Ser Tyr Lys Gly His Phe Gly Pro Ile His Cys Val Arg 
            260                 265                 270         


Phe Ser Pro Asp Gly Glu Leu Tyr Ala Ser Gly Ser Glu Asp Gly Thr 
        275                 280                 285             


Leu Arg Leu Trp Gln Thr Val Val Gly Lys Thr Tyr Gly Leu Trp Lys 
    290                 295                 300                 


Cys Val Leu Pro Glu Glu Asp Ser Gly Glu Leu Ala Lys Pro Lys Ile 
305                 310                 315                 320 


Gly Phe Pro Glu Thr Thr Glu Glu Glu Leu Glu Glu Ile Ala Ser Glu 
                325                 330                 335     


Asn Ser Asp Cys Ile Phe Pro Ser Ala Pro Asp Val Lys Ala 
            340                 345                 350 


<210>  375
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln 
1               5                   10                  15      


Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly 
            20                  25                  30          


Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala 
        35                  40                  45              


Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu 
    50                  55                  60                  


His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp 
65                  70                  75                  80  


Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg 
                85                  90                  95      


Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile 
            100                 105                 110         


Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg Tyr Gly Arg Arg Pro Tyr 
        115                 120                 125             


Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp Asp Met Gly Pro His Ile 
    130                 135                 140                 


Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe Asp Cys Arg Ala Met Ser 
145                 150                 155                 160 


Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr Tyr Leu Glu Arg His Met 
                165                 170                 175     


Ser Glu Phe Met Glu Cys Asn Leu Asn Glu Leu Val Lys His Gly Leu 
            180                 185                 190         


Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu Gln Asp Leu Thr Thr Lys 
        195                 200                 205             


Asn Val Ser Ile Gly Ile Val Gly Lys Asp Leu Glu Phe Thr Ile Tyr 
    210                 215                 220                 


Asp Asp Asp Asp Val Ser Pro Phe Leu Glu Gly Leu Glu Glu Arg Pro 
225                 230                 235                 240 


Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala Asp Glu Pro Ala Glu Lys 
                245                 250                 255     


Ala Asp Glu Pro Met Glu His 
            260             


<210>  376
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser 
1               5                   10                  15      


Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile 
            20                  25                  30          


Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly 
        35                  40                  45              


Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser 
    50                  55                  60                  


Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp 
                85                  90                  95      


Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly 
            100                 105                 110         


Leu Phe Asp 
        115 


<210>  377
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  378
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Ala Ser Leu Ser Leu Ala Pro Val Asn Ile Phe Lys Ala Gly Ala 
1               5                   10                  15      


Asp Glu Glu Arg Ala Glu Thr Ala Arg Leu Thr Ser Phe Ile Gly Ala 
            20                  25                  30          


Ile Ala Ile Gly Asp Leu Val Lys Ser Thr Leu Gly Pro Lys Gly Met 
        35                  40                  45              


Asp Lys Ile Leu Leu Ser Ser Gly Arg Asp Ala Ser Leu Met Val Thr 
    50                  55                  60                  


Asn Asp Gly Ala Thr Ile Leu Lys Asn Ile Gly Val Asp Asn Pro Ala 
65                  70                  75                  80  


Ala Lys Val Leu Val Asp Met Ser Arg Val Gln Asp Asp Glu Val Gly 
                85                  90                  95      


Asp Gly Thr Thr Ser Val Thr Val Leu Ala Ala Glu Leu Leu Arg Glu 
            100                 105                 110         


Ala Glu Ser Leu Ile Ala Lys Lys Ile His Pro Gln Thr Ile Ile Ala 
        115                 120                 125             


Gly Trp Arg Glu Ala Thr Lys Ala Ala Arg Glu Ala Leu Leu Ser Ser 
    130                 135                 140                 


Ala Val Asp His Gly Ser Asp Glu Val Lys Phe Arg Gln Asp Leu Met 
145                 150                 155                 160 


Asn Ile Ala Gly Thr Thr Leu Ser Ser Lys Leu Leu Thr His His Lys 
                165                 170                 175     


Asp His Phe Thr Lys Leu Ala Val Glu Ala Val Leu Arg Leu Lys Gly 
            180                 185                 190         


Ser Gly Asn Leu Glu Ala Ile His Ile Ile Lys Lys Leu Gly Gly Ser 
        195                 200                 205             


Leu Ala Asp Ser Tyr Leu Asp Glu Gly Phe Leu Leu Asp Lys Lys Ile 
    210                 215                 220                 


Gly Val Asn Gln Pro Lys Arg Ile Glu Asn Ala Lys Ile Leu Ile Ala 
225                 230                 235                 240 


Asn Thr Gly Met Asp Thr Asp Lys Ile Lys Ile Phe Gly Ser Arg Val 
                245                 250                 255     


Arg Val Asp Ser Thr Ala Lys Val Ala Glu Ile Glu His Ala Glu Lys 
            260                 265                 270         


Glu Lys Met Lys Glu Lys Val Glu Arg Ile Leu Lys His Gly Ile Asn 
        275                 280                 285             


Cys Phe Ile Asn Arg Gln Leu Ile Tyr Asn Tyr Pro Glu Gln Leu Phe 
    290                 295                 300                 


Gly Ala Ala Gly Val Met Ala Ile Glu His Ala Asp Phe Ala Gly Val 
305                 310                 315                 320 


Glu Arg Leu Ala Leu Val Thr Gly Gly Glu Ile Ala Ser Thr Phe Asp 
                325                 330                 335     


His Pro Glu Leu Val Lys Leu Gly Ser Cys Lys Leu Ile Glu Glu Val 
            340                 345                 350         


Met Ile Gly Glu Asp Lys Leu Ile His Phe Ser Gly Val Ala Leu Gly 
        355                 360                 365             


Glu Ala Cys Thr Ile Val Leu Arg Gly Ala Thr Gln Gln Ile Leu Asp 
    370                 375                 380                 


Glu Ala Glu Arg Ser Leu His Asp Ala Leu Cys Val Leu Ala Gln Thr 
385                 390                 395                 400 


Val Lys Asp Ser Arg Thr Val Tyr Gly Gly Gly Cys Ser Glu Met Leu 
                405                 410                 415     


Met Ala His Ala Val Thr Gln Leu Ala Asn Arg Thr Pro Gly Lys Glu 
            420                 425                 430         


Ala Val Ala Met Glu Ser Tyr Ala Lys Ala Leu Arg Met Leu Pro Thr 
        435                 440                 445             


Ile Ile Ala Asp Asn Ala Gly Tyr Asp Ser Ala Asp Leu Val Ala Gln 
    450                 455                 460                 


Leu Arg Ala Ala His Ser Glu Gly Asn Thr Thr Ala Gly Leu Asp Met 
465                 470                 475                 480 


Arg Glu Gly Thr Ile Gly Asp Met Ala Ile Leu Gly Ile Thr Glu Ser 
                485                 490                 495     


Phe Gln Val Lys Arg Gln Val Leu Leu Ser Ala Ala Glu Ala Ala Glu 
            500                 505                 510         


Val Ile Leu Arg Val Asp Asn Ile Ile Lys Ala Ala Pro Arg Lys Arg 
        515                 520                 525             


Val Pro Asp His His Pro Cys 
    530                 535 


<210>  379
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Thr Thr Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Thr Gly Arg Val Asp Lys Asn Ala Pro Thr Val Cys Gly His 
65                  70                  75                  80  


Thr Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Thr Leu Glu 
        115                 120                 125             


Gly His Thr Lys Arg Val Gly Ile Val Ala Trp His Thr Thr Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Thr Gly Ala Ala Met Leu Thr Leu Gly Pro Glu Val His Pro 
                165                 170                 175     


Asp Thr Ile Tyr Ser Val Asp Trp Ser Arg Asp Gly Gly Leu Ile Cys 
            180                 185                 190         


Thr Ser Cys Arg Asp Lys Arg Val Arg Ile Ile Glu Pro Arg Lys Gly 
        195                 200                 205             


Thr Val Val Ala Glu Lys Asp Arg Pro His Glu Gly Thr Arg Pro Val 
    210                 215                 220                 


Arg Ala Val Phe Val Ser Glu Gly Lys Ile Leu Thr Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Val Ala Leu Trp Asp Thr Lys His Leu Glu 
                245                 250                 255     


Glu Pro Leu Ser Leu Gln Glu Leu Asp Thr Ser Ser Gly Val Leu Leu 
            260                 265                 270         


Pro Phe Phe Asp Pro Asp Thr Asn Ile Val Tyr Leu Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Ser Glu Ala Pro Phe Leu 
    290                 295                 300                 


His Tyr Leu Ser Met Phe Ser Ser Lys Glu Ser Gln Arg Gly Met Gly 
305                 310                 315                 320 


Tyr Met Pro Lys Arg Gly Leu Glu Val Asn Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Arg Cys Glu Pro Ile Ala Met Thr Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Glu Asp Leu Tyr Pro Pro Thr Ala 
        355                 360                 365             


Gly Pro Asp Pro Ala Leu Thr Ala Glu Glu Trp Leu Gly Gly Arg Asp 
    370                 375                 380                 


Ala Gly Pro Leu Leu Ile Ser Leu Lys Asp Gly Tyr Val Pro Pro Lys 
385                 390                 395                 400 


Ser Arg Glu Leu Arg Val Asn Arg Gly Leu Asp Thr Gly Arg Arg Arg 
                405                 410                 415     


Ala Ala Pro Glu Ala Ser Gly Thr Pro Ser Ser Asp Ala Val Ser Arg 
            420                 425                 430         


Leu Glu Glu Glu Met Arg Lys Leu Gln Ala Thr Val Gln Glu Leu Gln 
        435                 440                 445             


Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
    450                 455                 460     


