                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  ANAPLASTIC THYROID CANCERS HARBOR NOVEL ONCOGENIC MUTATIONS OF 
       THE ALK GENE

<130>  P11563-02

<150>  61/487,151
<151>  2011-05-17

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for ALK mutant L1198F

<400>  1
catcctgctg gagttcatgg cgggggg                                           27


<210>  2
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense primer for ALK mutant L1198F

<400>  2
ccccccgcca tgaactccag caggatg                                           27


<210>  3
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for ALK mutant G1201E

<400>  3
gagctcatgg cggagggaga cctcaag                                           27


<210>  4
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense primer for ALK mutant G1201E

<400>  4
cttgaggtct ccctccgcca tgagctc                                           27


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector sequencing primer for confirming mutations

<400>  5
tctcgctgtg gtgacctctg                                                   20


<210>  6
<211>  6222
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6222)
<223>  Nucleic acid sequence for human ALK

<400>  6
gggggcggca gcggtggtag cagctggtac ctcccgccgc ctctgttcgg agggtcgcgg       60

ggcaccgagg tgctttccgg ccgccctctg gtcggccacc caaagccgcg ggcgctgatg      120

atgggtgagg agggggcggc aagatttcgg gcgcccctgc cctgaacgcc ctcagctgct      180

gccgccgggg ccgctccagt gcctgcgaac tctgaggagc cgaggcgccg gtgagagcaa      240

ggacgctgca aacttgcgca gcgcgggggc tgggattcac gcccagaagt tcagcaggca      300

gacagtccga agccttcccg cagcggagag atagcttgag ggtgcgcaag acggcagcct      360

ccgccctcgg ttcccgccca gaccgggcag aagagcttgg aggagccaaa aggaacgcaa      420

aaggcggcca ggacagcgtg cagcagctgg gagccgccgt tctcagcctt aaaagttgca      480

gagattggag gctgccccga gaggggacag accccagctc cgactgcggg gggcaggaga      540

ggacggtacc caactgccac ctcccttcaa ccatagtagt tcctctgtac cgagcgcagc      600

gagctacaga cgggggcgcg gcactcggcg cggagagcgg gaggctcaag gtcccagcca      660

gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg agcttccagg tctgtttcat      720

ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa gagacttgcg cgcacgcaca      780

gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa ggactgttca gagcctcttc      840

ccatctcggg gagagcgaag ggtgaggctg ggcccggaga gcagtgtaaa cggcctcctc      900

cggcgggatg ggagccatcg ggctcctgtg gctcctgccg ctgctgcttt ccacggcagc      960

tgtgggctcc gggatgggga ccggccagcg cgcgggctcc ccagctgcgg ggccgccgct     1020

gcagccccgg gagccactca gctactcgcg cctgcagagg aagagtctgg cagttgactt     1080

cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta ctgctgccac catcctcctc     1140

ggagctgaag gctggcaggc ccgaggcccg cggctcgcta gctctggact gcgccccgct     1200

gctcaggttg ctggggccgg cgccgggggt ctcctggacc gccggttcac cagccccggc     1260

agaggcccgg acgctgtcca gggtgctgaa gggcggctcc gtgcgcaagc tccggcgtgc     1320

caagcagttg gtgctggagc tgggcgagga ggcgatcttg gagggttgcg tcgggccccc     1380

cggggaggcg gctgtggggc tgctccagtt caatctcagc gagctgttca gttggtggat     1440

tcgccaaggc gaagggcgac tgaggatccg cctgatgccc gagaagaagg cgtcggaagt     1500

gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc cagccccgcc ttctcttcca     1560

gatcttcggg actggtcata gctccttgga atcaccaaca aacatgcctt ctccttctcc     1620

tgattatttt acatggaatc tcacctggat aatgaaagac tccttccctt tcctgtctca     1680

tcgcagccga tatggtctgg agtgcagctt tgacttcccc tgtgagctgg agtattcccc     1740

tccactgcat gacctcagga accagagctg gtcctggcgc cgcatcccct ccgaggaggc     1800

ctcccagatg gacttgctgg atgggcctgg ggcagagcgt tctaaggaga tgcccagagg     1860

ctcctttctc cttctcaaca cctcagctga ctccaagcac accatcctga gtccgtggat     1920

gaggagcagc agtgagcact gcacactggc cgtctcggtg cacaggcacc tgcagccctc     1980

tggaaggtac attgcccagc tgctgcccca caacgaggct gcaagagaga tcctcctgat     2040

gcccactcca gggaagcatg gttggacagt gctccaggga agaatcgggc gtccagacaa     2100

cccatttcga gtggccctgg aatacatctc cagtggaaac cgcagcttgt ctgcagtgga     2160

cttctttgcc ctgaagaact gcagtgaagg aacatcccca ggctccaaga tggccctgca     2220

gagctccttc acttgttgga atgggacagt cctccagctt gggcaggcct gtgacttcca     2280

ccaggactgt gcccagggag aagatgagag ccagatgtgc cggaaactgc ctgtgggttt     2340

ttactgcaac tttgaagatg gcttctgtgg ctggacccaa ggcacactgt caccccacac     2400

tcctcaatgg caggtcagga ccctaaagga tgcccggttc caggaccacc aagaccatgc     2460

tctattgctc agtaccactg atgtccccgc ttctgaaagt gctacagtga ccagtgctac     2520

gtttcctgca ccgatcaaga gctctccatg tgagctccga atgtcctggc tcattcgtgg     2580

agtcttgagg ggaaacgtgt ccttggtgct agtggagaac aaaaccggga aggagcaagg     2640

caggatggtc tggcatgtcg ccgcctatga aggcttgagc ctgtggcagt ggatggtgtt     2700

gcctctcctc gatgtgtctg acaggttctg gctgcagatg gtcgcatggt ggggacaagg     2760

atccagagcc atcgtggctt ttgacaatat ctccatcagc ctggactgct acctcaccat     2820

tagcggagag gacaagatcc tgcagaatac agcacccaaa tcaagaaacc tgtttgagag     2880

aaacccaaac aaggagctga aacccgggga aaattcacca agacagaccc ccatctttga     2940

ccctacagtt cattggctgt tcaccacatg tggggccagc gggccccatg gccccaccca     3000

ggcacagtgc aacaacgcct accagaactc caacctgagc gtggaggtgg ggagcgaggg     3060

ccccctgaaa ggcatccaga tctggaaggt gccagccacc gacacctaca gcatctcggg     3120

ctacggagct gctggcggga aaggcgggaa gaacaccatg atgcggtccc acggcgtgtc     3180

tgtgctgggc atcttcaacc tggagaagga tgacatgctg tacatcctgg ttgggcagca     3240

gggagaggac gcctgcccca gtacaaacca gttaatccag aaagtctgca ttggagagaa     3300

caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg catgagtggg caggaggcgg     3360

aggaggaggg ggtggagcca cctacgtatt taagatgaag gatggagtgc cggtgcccct     3420

gatcattgca gccggaggtg gtggcagggc ctacggggcc aagacagaca cgttccaccc     3480

agagagactg gagaataact cctcggttct agggctaaac ggcaattccg gagccgcagg     3540

tggtggaggt ggctggaatg ataacacttc cttgctctgg gccggaaaat ctttgcagga     3600

gggtgccacc ggaggacatt cctgccccca ggccatgaag aagtgggggt gggagacaag     3660

agggggtttc ggagggggtg gaggggggtg ctcctcaggt ggaggaggcg gaggatatat     3720

aggcggcaat gcagcctcaa acaatgaccc cgaaatggat ggggaagatg gggtttcctt     3780

catcagtcca ctgggcatcc tgtacacccc agctttaaaa gtgatggaag gccacgggga     3840

agtgaatatt aagcattatc taaactgcag tcactgtgag gtagacgaat gtcacatgga     3900

ccctgaaagc cacaaggtca tctgcttctg tgaccacggg acggtgctgg ctgaggatgg     3960

cgtctcctgc attgtgtcac ccaccccgga gccacacctg ccactctcgc tgatcctctc     4020

tgtggtgacc tctgccctcg tggccgccct ggtcctggct ttctccggca tcatgattgt     4080

gtaccgccgg aagcaccagg agctgcaagc catgcagatg gagctgcaga gccctgagta     4140

caagctgagc aagctccgca cctcgaccat catgaccgac tacaacccca actactgctt     4200

tgctggcaag acctcctcca tcagtgacct gaaggaggtg ccgcggaaaa acatcaccct     4260

cattcggggt ctgggccatg gcgcctttgg ggaggtgtat gaaggccagg tgtccggaat     4320

gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg ctgcctgaag tgtgctctga     4380

acaggacgaa ctggatttcc tcatggaagc cctgatcatc agcaaattca accaccagaa     4440

cattgttcgc tgcattgggg tgagcctgca atccctgccc cggttcatcc tgctggagct     4500

catggcgggg ggagacctca agtccttcct ccgagagacc cgccctcgcc cgagccagcc     4560

ctcctccctg gccatgctgg accttctgca cgtggctcgg gacattgcct gtggctgtca     4620

gtatttggag gaaaaccact tcatccaccg agacattgct gccagaaact gcctcttgac     4680

ctgtccaggc cctggaagag tggccaagat tggagacttc gggatggccc gagacatcta     4740

cagggcgagc tactatagaa agggaggctg tgccatgctg ccagttaagt ggatgccccc     4800

agaggccttc atggaaggaa tattcacttc taaaacagac acatggtcct ttggagtgct     4860

gctatgggaa atcttttctc ttggatatat gccatacccc agcaaaagca accaggaagt     4920

tctggagttt gtcaccagtg gaggccggat ggacccaccc aagaactgcc ctgggcctgt     4980

ataccggata atgactcagt gctggcaaca tcagcctgaa gacaggccca actttgccat     5040

cattttggag aggattgaat actgcaccca ggacccggat gtaatcaaca ccgctttgcc     5100

gatagaatat ggtccacttg tggaagagga agagaaagtg cctgtgaggc ccaaggaccc     5160

tgagggggtt cctcctctcc tggtctctca acaggcaaaa cgggaggagg agcgcagccc     5220

agctgcccca ccacctctgc ctaccacctc ctctggcaag gctgcaaaga aacccacagc     5280

tgcagagatc tctgttcgag tccctagagg gccggccgtg gaagggggac acgtgaatat     5340

ggcattctct cagtccaacc ctccttcgga gttgcacaag gtccacggat ccagaaacaa     5400

gcccaccagc ttgtggaacc caacgtacgg ctcctggttt acagagaaac ccaccaaaaa     5460

gaataatcct atagcaaaga aggagccaca cgacaggggt aacctggggc tggagggaag     5520

ctgtactgtc ccacctaacg ttgcaactgg gagacttccg ggggcctcac tgctcctaga     5580

gccctcttcg ctgactgcca atatgaagga ggtacctctg ttcaggctac gtcacttccc     5640

ttgtgggaat gtcaattacg gctaccagca acagggcttg cccttagaag ccgctactgc     5700

ccctggagct ggtcattacg aggataccat tctgaaaagc aagaatagca tgaaccagcc     5760

tgggccctga gctcggtcgc acactcactt ctcttccttg ggatccctaa gaccgtggag     5820

gagagagagg caatggctcc ttcacaaacc agagaccaaa tgtcacgttt tgttttgtgc     5880

caacctattt tgaagtacca ccaaaaaagc tgtattttga aaatgcttta gaaaggtttt     5940

gagcatgggt tcatcctatt ctttcgaaag aagaaaatat cataaaaatg agtgataaat     6000

acaaggccca gatgtggttg cataaggttt ttatgcatgt ttgttgtata cttccttatg     6060

cttctttcaa attgtgtgtg ctctgcttca atgtagtcag aattagctgc ttctatgttt     6120

catagttggg gtcatagatg tttccttgcc ttgttgatgt ggacatgagc catttgaggg     6180

gagagggaac ggaaataaag gagttatttg taatgactaa aa                        6222


<210>  7
<211>  1620
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1620)
<223>  Amino acid sequence for human ALK

<400>  7

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer for exon 23 of the ALK gene

<400>  8
aagatttgcc cagactcagc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer for exon 23 of the ALK gene

<400>  9
tgtccttggc acaacaactg                                                   20


