                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> FGFR1 AGONISTS AND METHODS OF USE

<130> P4653R1WO

<140>
<141>

<150> 61/536,936
<151> 2011-09-20

<150> 61/486,731
<151> 2011-05-16

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1
Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
1               5                   10                  15      


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
            20                  25                  30          


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
        35                  40                  45              


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
    50                  55                  60                  


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
65                  70                  75                  80  


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
                85                  90                  95      


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
            100                 105                 110         


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
        115                 120                 125             


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
    130                 135                 140                 


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
145                 150                 155                 160 


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
                165                 170                 175     


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
            180                 185                 190         


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
        195                 200                 205             


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
    210                 215                 220                 


Ala Val Met Thr Ser 
225                 


<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Thr 
            20                  25                  30          


Trp Ile Ser Trp Val Pro Gly Lys Gly Leu Glu Trp Val Gly Glu Ile 
        35                  40                  45              


Asp Pro Tyr Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Gly Tyr Gly 
                85                  90                  95      


Gly Ser Asp Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105         


<210> 3
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          


Tyr Ile His Trp Val Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Ile 
        35                  40                  45              


Tyr Pro Asn Asp Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Phe Asp 
                85                  90                  95      


Ala Trp Val His Tyr Tyr Val Met Asp Tyr Trp Gly Gln 
            100                 105                 


<210> 4
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Ile Ser Trp Val Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile 
        35                  40                  45              


Asp Pro Tyr Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Gly Thr Asp Val 
                85                  90                  95      


Met Asp Tyr Trp Gly Gln 
            100         


<210> 5
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5
Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
1               5                   10                  15      


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
            20                  25                  30          


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
        35                  40                  45              


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
    50                  55                  60                  


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
65                  70                  75                  80  


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
                85                  90                  95      


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
            100                 105                 110         


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
        115                 120                 125             


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
    130                 135                 140                 


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
145                 150                 155                 160 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
                165                 170                 175     


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
            180                 185                 190         


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
        195                 200                 205             


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
    210                 215                 220                 


Met Thr Ser 
225         


<210> 6
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Gly Phe Thr Phe Thr Ser Thr Trp Ile Ser 
1               5                   10  


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Gly Phe Thr Phe Ser Asn Asn Tyr Ile His 
1               5                   10  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Phe Thr Phe Thr Ser Asn Trp Ile Ser 
1               5                   10  


<210> 10
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Gly Glu Ile Asp Pro Tyr Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Glu Ile Asp Pro Tyr Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Ala Asp Ile Tyr Pro Asn Asp Gly Asp Thr Asp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Asp Ile Tyr Pro Asn Asp Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 14
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Ala Glu Ile Asp Pro Tyr Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Glu Ile Asp Pro Tyr Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Ser Ser Gly Tyr Gly Gly Ser Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Ser Gly Tyr Gly Gly Ser Asp Tyr Ala Met Asp Tyr 
1               5                   10          


<210> 18
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Glu His Phe Asp Ala Trp Val His Tyr Tyr Val Met Asp Tyr 
1               5                   10                  


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Thr Gly Thr Asp Val Met Asp Tyr 
1               5               


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Thr Asp Val Met Asp Tyr 
1               5           


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to the annotations for said positions"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (4)..(4)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (6)..(6)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (9)..(9)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (11)..(11)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 24
Ala Asp Ile Asp Pro Asn Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210> 25
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Glu"

<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (3)..(3)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (5)..(5)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (8)..(8)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 25
Asp Ile Asp Pro Asn Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Thr"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (5)..(8)
<223> /note="Residues given in the sequence have no preference 
      with respect to the annotations for said positions"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 26
Gly Phe Thr Phe Ser Asn Asn Trp Ile His 
1               5                   10  


<210> 27
<211> 53
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
1               5                   10                  15      


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            20                  25                  30          


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        35                  40                  45              


Arg Tyr Ala Thr Trp 
    50              


<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro 
1               5                   10                  15      


<210> 29
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
1               5                   10                  


<210> 30
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro 
1               5                   10                  15      


<210> 31
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro 
1               5                   10                  15      


<210> 32
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro 
1               5                   10                  15      


<210> 33
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
1               5                   10                  


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
1               5                   10                  


<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His 
1               5                   10                  


<210> 36
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val 
1               5                   10                  15      


Ala Pro Tyr 
            


<210> 37
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu 
1               5                   10                  15      


His Ala Val 
            


<210> 38
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro 
1               5                   10                  15      


Ser Ser Gly 
            


<210> 39
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn 
1               5                   10                  15      


Gly Lys Glu 
            


<210> 40
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys 
1               5                   10                  15      


Val Arg Tyr 
            


<210> 41
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val 
1               5                   10                  15      


Pro Ser Asp 
            


<210> 42
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
1               5                   10                  15      


Tyr Gly Ser 
            


<210> 43
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu 
1               5                   10                  15      


Arg Ser Pro 
            


<210> 44
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
1               5                   10                  15      


Asn Lys Thr 
            


<210> 45
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys 
1               5                   10                  15      


Lys Val Tyr 
            


<210> 46
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys 
1               5                   10                  15      


His Ile Glu 
            


<210> 47
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu 
1               5                   10                  15      


Pro Tyr Val 
            


<210> 48
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr 
1               5                   10                  15      


Asp Lys Glu 
            


<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe 
1               5                   10                  15      


Glu Asp Ala 
            


<210> 50
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
1               5                   10                  15      


Gly Leu Ser 
            


<210> 51
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala 
1               5                   10                  15      


Leu Glu Glu 
            


<210> 52
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro 
1               5                   10                  15      


Ala Ala Lys 
            


<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val 
1               5                   10                  15      


Lys Phe Lys 
            


<210> 54
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro 
1               5                   10                  15      


Asn Pro Thr 
            


<210> 55
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp 
1               5                   10                  15      


Leu Lys Asn 
            


<210> 56
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe 
1               5                   10                  15      


Lys Pro Asp 
            


<210> 57
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg 
1               5                   10                  15      


Ile Gly Gly 
            


<210> 58
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr 
1               5                   10                  15      


Trp Ser Ile 
            


<210> 59
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile 
1               5                   10                  15      


Met Asp Ser 
            


<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser 
1               5                   10                  15      


Ser 
    


<210> 61
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly 
1               5                   10                  15      


<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg 
1               5                   10          


<210> 63
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn 
1               5                   10          


