                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       Vainstein, Alexander
       Marhevka, Elena
       Farhi, Moran
 
<120>  METHODS OF PRODUCING ARTEMISININ IN NON-HOST PLANTS AND VECTORS 
       FOR USE IN SAME

<130>  53908

<150>  US 61/486,546
<151>  2011-05-16

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
atgtcactta cagaagaaaa acctattcg                                         29


<210>  2
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
tgatcaatct cccgttcaaa gtga                                              24


<210>  3
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
gcggccgcaa aacaatgctt tcactacgtc aatcta                                 36


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
tgatgtttcc gcattggttg a                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
actttgaacc aaatggccgg                                                   20


<210>  6
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
gcggccgcat gtctgaaaaa ccaaccttg                                         29


<210>  7
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
atcgattgca ggggagattc taataccaac tcggtctgta ccaatggctg cagataccgc       60

ttgcac                                                                  66


<210>  8
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
ctcaaagaca gtgctgaatt cccatt                                            26


<210>  9
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
ctagaaactt ggaacgagta acaactca                                          28


<210>  10
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
atctggaatt tactctctga gggagca                                           27


<210>  11
<211>  546
<212>  PRT
<213>  Artemisia annua

<400>  11

Met Ser Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro 
1               5                   10                  15      


Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu 
            20                  25                  30          


Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln 
        35                  40                  45              


Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu 
    50                  55                  60                  


Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu 
65                  70                  75                  80  


Arg Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp 
                85                  90                  95      


Asn Trp Asn Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys 
            100                 105                 110         


Gln Gly Tyr Tyr Val Thr Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys 
        115                 120                 125             


Asn Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Ile Leu 
145                 150                 155                 160 


Glu Asp Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ile Met Thr Lys 
                165                 170                 175     


Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala 
            180                 185                 190         


Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln 
        195                 200                 205             


Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu 
    210                 215                 220                 


Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu 
225                 230                 235                 240 


Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys 
                245                 250                 255     


Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly 
            260                 265                 270         


Leu Gly Ser Gly Tyr Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe 
        275                 280                 285             


Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg 
305                 310                 315                 320 


Trp Ser Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile 
                325                 330                 335     


Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala 
            340                 345                 350         


Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Gly Lys Glu Phe Val Lys 
        355                 360                 365             


Glu Phe Val Arg Asn Leu Met Val Glu Ala Lys Trp Ala Asn Glu Gly 
    370                 375                 380                 


His Ile Pro Thr Thr Glu Glu His Asp Pro Val Val Ile Ile Thr Gly 
385                 390                 395                 400 


Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile 
                405                 410                 415     


Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe 
            420                 425                 430         


Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His 
        435                 440                 445             


Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr 
    450                 455                 460                 


Met Lys Glu Tyr Asn Val Asn Glu Glu Tyr Ala Gln Thr Leu Ile Tyr 
465                 470                 475                 480 


Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr 
                485                 490                 495     


Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys 
            500                 505                 510         


Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met 
        515                 520                 525             


Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met 
    530                 535                 540                 


Ser Ile 
545     


<210>  12
<211>  546
<212>  PRT
<213>  Artemisia annua

<400>  12

Met Ala Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro 
1               5                   10                  15      


Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu 
            20                  25                  30          


Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln 
        35                  40                  45              


Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu 
    50                  55                  60                  


Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu 
65                  70                  75                  80  


Arg Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp 
                85                  90                  95      


Asn Trp Asn Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys 
            100                 105                 110         


Gln Gly Tyr Tyr Val Thr Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys 
        115                 120                 125             


Asn Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Ile Leu 
145                 150                 155                 160 


Glu Asp Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ile Met Thr Lys 
                165                 170                 175     


Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala 
            180                 185                 190         


Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln 
        195                 200                 205             


Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu 
    210                 215                 220                 


Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu 
225                 230                 235                 240 


Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys 
                245                 250                 255     


Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly 
            260                 265                 270         


Leu Gly Ser Gly Tyr Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe 
        275                 280                 285             


Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg 
305                 310                 315                 320 


Trp Ser Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile 
                325                 330                 335     


Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala 
            340                 345                 350         


Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Gly Lys Glu Phe Val Lys 
        355                 360                 365             


Glu Phe Val Arg Asn Leu Met Val Glu Ala Lys Trp Ala Asn Glu Gly 
    370                 375                 380                 


His Ile Pro Thr Thr Glu Glu His Asp Pro Val Val Ile Ile Thr Gly 
385                 390                 395                 400 


Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile 
                405                 410                 415     


Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe 
            420                 425                 430         


Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His 
        435                 440                 445             


Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr 
    450                 455                 460                 


Met Lys Glu Tyr Asn Val Asn Glu Glu Tyr Ala Gln Thr Leu Ile Tyr 
465                 470                 475                 480 


Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr 
                485                 490                 495     


Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys 
            500                 505                 510         


Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met 
        515                 520                 525             


Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met 
    530                 535                 540                 


Ser Ile 
545     


<210>  13
<211>  1641
<212>  DNA
<213>  Artemisia annua

<400>  13
atggccttga ctgaagagaa acctataagg ccaattgcaa atttcccacc ttctatttgg       60

ggcgatcaat ttttgattta tgagaaacaa gttgaacagg gtgtggagca aatagtaaac      120

gatctaaaga aggaagtaag acagttgtta aaggaagcat tggatattcc tatgaaacat      180

gcaaatttgt tgaagctgat tgacgagatt caacgtttag gtattccgta tcattttgaa      240

cgtgaaattg atcatgcatt gcaatgtatt tacgagacct atggtgataa ttggaatggc      300

gacaggtcta gcttatggtt taggctgatg cgtaaacaag gatactatgt cacgtgtgat      360

gtgtttaata actataaaga caagaatggt gcttttaaac aatcgttagc gaatgatgtt      420

gaaggattgt tggaattata tgaggctacg tccatgagag ttccgggcga aataattctt      480

gaagatgccc tgggattcac aagatcaagg ctatcgatta tgacaaagga cgcgtttagt      540

acaaaccccg ctttattcac tgaaatccag agagctttaa agcaaccatt gtggaagaga      600

ttgccaagga tcgaggccgc ccagtacata cccttctatc agcaacaaga ctcccataat      660

aaaactctgc taaagttagc taaactggag ttcaatctat tgcagagcct acataaggaa      720

gagttgagtc acgtatgcaa gtggtggaag gcatttgata ttaagaaaaa tgccccatgt      780

ctgagagatc gtatcgttga atgctatttt tggggtttag gttctggtta cgaaccccag      840

tattcaagag ctagagtttt tttcactaag gcagttgctg tgataacact tattgatgac      900

acgtatgacg catatggaac ttacgaggag ttaaagattt tcactgaagc cgtggaaaga      960

tggtcgatca cctgcttaga cacgttgccg gaatacatga agcctattta caaattattc     1020

atggatacct acacagaaat ggaggagttt ctggccaaag aaggtagaac tgatttattc     1080

aactgtggga aggagttcgt taaagaattc gtaaggaatc taatggtaga agcgaaatgg     1140

gctaatgaag gacacatacc gacaactgaa gagcacgatc ccgtagttat tatcactggt     1200

ggtgcaaact tgctaacaac tacctgttat ctaggaatga gcgatatttt cactaaggaa     1260

tcagttgagt gggctgtatc tgctccgcct ttattccgtt acagtggtat tctgggtagg     1320

agattaaatg acctgatgac tcataaagcg gaacaggaga gaaaacatag ttcaagctct     1380

ttagaatctt acatgaagga atacaatgtc aacgaagaat atgctcagac actgatttat     1440

aaggaagtgg aggacgtttg gaaagacata aacagagagt atttaacaac aaagaatatc     1500

ccaagacctt tacttatggc tgttatatat ctttgccaat ttttagaggt ccaatatgca     1560

ggtaaagaca attttacgag aatgggagat gaatacaagc atttgatcaa atcattgcta     1620

gtttacccta tgtctatcta a                                               1641


<210>  14
<211>  387
<212>  PRT
<213>  Artemisia annua

<400>  14

Met Ser Glu Lys Pro Thr Leu Phe Ser Ala Tyr Lys Met Gly Lys Phe 
1               5                   10                  15      


Asn Leu Ser His Arg Val Val Leu Ala Pro Met Thr Arg Cys Arg Ala 
            20                  25                  30          


Ile Asn Ala Ile Pro Asn Glu Ala Leu Val Glu Tyr Tyr Arg Gln Arg 
        35                  40                  45              


Ser Thr Ala Gly Gly Phe Leu Ile Thr Glu Gly Thr Met Ile Ser Pro 
    50                  55                  60                  


Ser Ser Ala Gly Phe Pro His Val Pro Gly Ile Phe Thr Lys Glu Gln 
65                  70                  75                  80  


Val Glu Gly Trp Lys Lys Val Val Asp Ala Ala His Lys Glu Gly Ala 
                85                  90                  95      


Val Ile Phe Cys Gln Leu Trp His Val Gly Arg Ala Ser His Gln Val 
            100                 105                 110         


Tyr Gln Pro Gly Gly Ala Ala Pro Ile Ser Ser Thr Ser Lys Pro Ile 
        115                 120                 125             


Ser Lys Lys Trp Glu Ile Leu Leu Pro Asp Ala Thr Tyr Gly Thr Tyr 
    130                 135                 140                 


Pro Glu Pro Arg Pro Leu Ala Ala Asn Glu Ile Leu Glu Val Val Glu 
145                 150                 155                 160 


Asp Tyr Arg Val Ala Ala Ile Asn Ala Ile Glu Ala Gly Phe Asp Gly 
                165                 170                 175     


Ile Glu Ile His Gly Ala His Gly Tyr Leu Leu Asp Gln Phe Met Lys 
            180                 185                 190         


Asp Gly Ile Asn Asp Arg Thr Asp Glu Tyr Gly Gly Ser Leu Glu Asn 
        195                 200                 205             


Arg Cys Lys Phe Ile Leu Gln Val Val Gln Ala Val Ser Ala Ala Ile 
    210                 215                 220                 


Gly Thr Asp Arg Val Gly Ile Arg Ile Ser Pro Ala Ile Asp His Thr 
225                 230                 235                 240 


Asp Ala Met Asp Ser Asp Pro Arg Ser Leu Gly Leu Ala Val Ile Glu 
                245                 250                 255     


Arg Leu Asn Lys Leu Gln Phe Lys Leu Gly Ser Arg Leu Ala Tyr Leu 
            260                 265                 270         


His Val Thr Gln Pro Arg Tyr Thr Ala Asp Gly His Gly Gln Thr Glu 
        275                 280                 285             


Ala Gly Ala Asn Gly Ser Glu Glu Glu Val Ala Gln Leu Met Lys Thr 
    290                 295                 300                 


Trp Arg Gly Ala Tyr Val Gly Thr Phe Ile Cys Cys Gly Gly Tyr Thr 
305                 310                 315                 320 


Arg Glu Leu Gly Leu Gln Ala Val Ala Gln Gly Asp Ala Asp Leu Val 
                325                 330                 335     


Ala Phe Gly Arg Tyr Phe Val Ser Asn Pro Asp Leu Val Leu Arg Leu 
            340                 345                 350         


Lys Leu Asn Ala Pro Leu Asn Arg Tyr Asp Arg Ala Thr Phe Tyr Thr 
        355                 360                 365             


His Asp Pro Val Val Gly Tyr Thr Asp Tyr Pro Ser Leu Asp Lys Gly 
    370                 375                 380                 


Ser Leu Leu 
385         


<210>  15
<211>  1164
<212>  DNA
<213>  Artemisia annua

<400>  15
atgtctgaaa aaccaacctt gttttctgcc tacaagatgg gcaagttcaa tctttctcac       60

agggtggtgt tagctcctat gactcggtgt cgggcaataa acgctatacc gaacgaagcg      120

cttgtcgaat attatcggca aagatcaact gctggtggct ttcttattac cgaggggact      180

atgatctctc cttcttctgc cgggtttccg cacgtaccgg gtatttttac taaggaacaa      240

gtcgagggtt ggaaaaaagt ggttgatgca gctcacaaag aaggggctgt gatattttgt      300

caattgtggc atgttggtag agcatcccat caagtgtacc aacccggtgg tgctgcgcca      360

atatcatcaa caagcaagcc catttcaaag aagtgggaaa tattattgcc agatgcaacc      420

tatggcacgt atcctgagcc ccgtccattg gcagccaatg aaatactaga ggtggttgaa      480

gactatcgcg ttgcagctat taatgctatt gaagcaggtt ttgatggcat tgaaatacat      540

ggagcacatg gttatctact tgaccagttc atgaaagatg gcataaatga cagaacggac      600

gaatatggtg ggtcattaga aaaccgctgc aaattcatac tgcaagtagt gcaagcggta      660

tctgcagcca ttggtacaga ccgagttggt attagaatct cccctgcaat cgatcacaca      720

gatgctatgg actctgatcc acgaagccta ggccttgcag taattgaaag actcaacaaa      780

ctacaattta aattagggtc aagactagct tatcttcatg taactcaacc acgttacacg      840

gctgatggtc atggtcaaac agaagcggga gccaatggaa gtgaggagga agtagctcag      900

ttgatgaaaa catggagagg agcttatgtg ggaactttta tatgctgcgg tggttacact      960

agagaacttg ggttacaagc tgtggctcaa ggggatgctg atttggtcgc ttttggtcgt     1020

tattttgtct cgaatcctga ccttgtttta agacttaagc tcaacgcacc tttaaatagg     1080

tatgacagag ctacttttta tacccatgat cctgtcgttg ggtacacgga ttacccttct     1140

cttgacaaag ggtcactcct ctag                                            1164


<210>  16
<211>  488
<212>  PRT
<213>  Artemisia annua

<400>  16

Met Ala Leu Ser Leu Thr Thr Ser Ile Ala Leu Ala Thr Ile Leu Leu 
1               5                   10                  15      


Phe Val Tyr Lys Phe Ala Thr Arg Ser Lys Ser Thr Lys Lys Ser Leu 
            20                  25                  30          


Pro Glu Pro Trp Arg Leu Pro Ile Ile Gly His Met His His Leu Ile 
        35                  40                  45              


Gly Thr Thr Pro His Arg Gly Val Arg Asp Leu Ala Arg Lys Tyr Gly 
    50                  55                  60                  


Ser Leu Met His Leu Gln Leu Gly Glu Val Pro Thr Ile Val Val Ser 
65                  70                  75                  80  


Ser Pro Lys Trp Ala Lys Glu Ile Leu Thr Thr Tyr Asp Ile Thr Phe 
                85                  90                  95      


Ala Asn Arg Pro Glu Thr Leu Thr Gly Glu Ile Val Leu Tyr His Asn 
            100                 105                 110         


Thr Asp Val Val Leu Ala Pro Tyr Gly Glu Tyr Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Ile Cys Thr Leu Glu Leu Leu Ser Val Lys Lys Val Lys Ser Phe 
    130                 135                 140                 


Gln Ser Leu Arg Glu Glu Glu Cys Trp Asn Leu Val Gln Glu Ile Lys 
145                 150                 155                 160 


Ala Ser Gly Ser Gly Arg Pro Val Asn Leu Ser Glu Asn Ile Phe Lys 
                165                 170                 175     


Leu Ile Ala Thr Ile Leu Ser Arg Ala Ala Phe Gly Lys Gly Ile Lys 
            180                 185                 190         


Asp Gln Lys Glu Leu Thr Glu Ile Val Lys Glu Ile Leu Arg Gln Thr 
        195                 200                 205             


Gly Gly Phe Asp Val Ala Asp Ile Phe Pro Ser Lys Lys Phe Leu His 
    210                 215                 220                 


His Leu Ser Gly Lys Arg Ala Arg Leu Thr Ser Leu Arg Lys Lys Ile 
225                 230                 235                 240 


Asp Asn Leu Ile Asp Asn Leu Val Ala Glu His Thr Val Asn Thr Ser 
                245                 250                 255     


Ser Lys Thr Asn Glu Thr Leu Leu Asp Val Leu Leu Arg Leu Lys Asp 
            260                 265                 270         


Ser Ala Glu Phe Pro Leu Thr Ser Asp Asn Ile Lys Ala Ile Ile Leu 
        275                 280                 285             


Asp Met Phe Gly Ala Gly Thr Asp Thr Ser Ser Ser Thr Ile Glu Trp 
    290                 295                 300                 


Ala Ile Ser Glu Leu Ile Lys Cys Pro Lys Ala Met Glu Lys Val Gln 
305                 310                 315                 320 


Ala Glu Leu Arg Lys Ala Leu Asn Gly Lys Glu Lys Ile His Glu Glu 
                325                 330                 335     


Asp Ile Gln Glu Leu Ser Tyr Leu Asn Met Val Ile Lys Glu Thr Leu 
            340                 345                 350         


Arg Leu His Pro Pro Leu Pro Leu Val Leu Pro Arg Glu Cys Arg Gln 
        355                 360                 365             


Pro Val Asn Leu Ala Gly Tyr Asn Ile Pro Asn Lys Thr Lys Leu Ile 
    370                 375                 380                 


Val Asn Val Phe Ala Ile Asn Arg Asp Pro Glu Tyr Trp Lys Asp Ala 
385                 390                 395                 400 


Glu Ala Phe Ile Pro Glu Arg Phe Glu Asn Ser Ser Ala Thr Val Met 
                405                 410                 415     


Gly Ala Glu Tyr Glu Tyr Leu Pro Phe Gly Ala Gly Arg Arg Met Cys 
            420                 425                 430         


Pro Gly Ala Ala Leu Gly Leu Ala Asn Val Gln Leu Pro Leu Ala Asn 
        435                 440                 445             


Ile Leu Tyr His Phe Asn Trp Lys Leu Pro Asn Gly Val Ser Tyr Asp 
    450                 455                 460                 


Gln Ile Asp Met Thr Glu Ser Ser Gly Ala Thr Met Gln Arg Lys Thr 
465                 470                 475                 480 


Glu Leu Leu Leu Val Pro Ser Phe 
                485             


<210>  17
<211>  1467
<212>  DNA
<213>  Artemisia annua

<400>  17
atggcactct cactgaccac ttccattgct cttgcaacga tccttttgtt cgtttacaag       60

ttcgctactc gttccaaatc caccaaaaaa agccttcctg agccatggcg acttcccatt      120

attggtcaca tgcatcactt gattggtaca acgccacatc gtggggttag ggatttagcc      180

agaaagtatg gatctttgat gcatttacag cttggtgaag ttccaacaat cgtggtgtca      240

tctccgaaat gggctaaaga gattttgaca acgtacgaca ttacctttgc taacaggccc      300

gagactttaa ctggtgagat tgttttatat cacaatacgg atgttgttct tgcaccttat      360

ggtgaatact ggaggcaatt acgtaaaatt tgcacattgg agcttttgag tgttaagaaa      420

gtaaagtcat ttcagtcgct tcgtgaagag gagtgttgga atttggttca agagattaaa      480

gcttcaggtt cagggagacc ggttaacctt tcagagaata ttttcaagtt gattgcaacg      540

atacttagta gagccgcatt tgggaaaggg atcaaggacc agaaagagtt aacggagatt      600

gtgaaagaga tactgaggca aactggtggt tttgatgtgg cagatatctt tccttcaaag      660

aaatttcttc atcatctttc gggcaagaga gctcggttaa ctagccttcg caaaaagatc      720

gataatttaa tcgataacct tgtagctgag catactgtta acacctccag taaaactaac      780

gagacactcc tcgatgttct tttaaggctc aaagacagtg ctgaattccc attaacatct      840

gataacatta aagccatcat tttggatatg tttggagcag gcacagacac ttcctcatcc      900

acaatcgaat gggcgatttc ggaactcata aagtgtccga aagcaatgga gaaagtacaa      960

gcggaattga ggaaagcatt gaacggaaaa gaaaagatcc atgaggaaga cattcaagaa     1020

ctaagctact tgaacatggt aatcaaagaa acattgaggt tgcaccctcc actacccttg     1080

gttctgccaa gagagtgccg ccaaccagtc aatttggctg gatacaacat acccaataag     1140

accaaactta ttgtcaacgt ctttgcgata aatagggacc ctgaatattg gaaagacgct     1200

gaagctttca tccctgaacg atttgaaaat agttctgcaa ctgtcatggg tgcagaatac     1260

gagtatcttc cgtttggagc tgggagaagg atgtgtcctg gagccgcact tggtttagct     1320

aacgtgcagc tcccgctcgc taatatacta tatcatttca actggaaact ccccaatggt     1380

gtgagctatg accagatcga catgaccgag agctctggag ccacgatgca aagaaagact     1440

gagttgttac tcgttccaag tttctag                                         1467


<210>  18
<211>  495
<212>  PRT
<213>  Artemisia annua

<400>  18

Met Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser Ile 
1               5                   10                  15      


Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Lys Phe Ala Thr Arg Ser 
            20                  25                  30          


Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile 
        35                  40                  45              


Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val Arg 
    50                  55                  60                  


Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly Glu 
65                  70                  75                  80  


Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile Leu 
                85                  90                  95      


Thr Thr Tyr Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly 
            100                 105                 110         


Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly 
        115                 120                 125             


Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser 
    130                 135                 140                 


Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys Trp 
145                 150                 155                 160 


Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn 
                165                 170                 175     


Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala 
            180                 185                 190         


Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val 
        195                 200                 205             


Lys Glu Ile Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe 
    210                 215                 220                 


Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu 
225                 230                 235                 240 


Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala 
                245                 250                 255     


Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp 
            260                 265                 270         


Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp 
        275                 280                 285             


Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr 
    290                 295                 300                 


Ser Ser Ser Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Cys Pro 
305                 310                 315                 320 


Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly 
                325                 330                 335     


Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn 
            340                 345                 350         


Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Val 
        355                 360                 365             


Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile 
    370                 375                 380                 


Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp 
385                 390                 395                 400 


Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu 
                405                 410                 415     


Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe 
            420                 425                 430         


Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn 
        435                 440                 445             


Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu 
    450                 455                 460                 


Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly 
465                 470                 475                 480 


Ala Thr Met Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495 


<210>  19
<211>  488
<212>  PRT
<213>  Artemisia annua

<400>  19

Met Ala Leu Ser Leu Thr Thr Ser Ile Ala Leu Ala Thr Ile Leu Leu 
1               5                   10                  15      


Phe Val Tyr Lys Phe Ala Thr Arg Ser Lys Ser Thr Lys Lys Ser Leu 
            20                  25                  30          


Pro Glu Pro Trp Arg Leu Pro Ile Ile Gly His Met His His Leu Ile 
        35                  40                  45              


Gly Thr Thr Pro His Arg Gly Val Arg Asp Leu Ala Arg Lys Tyr Gly 
    50                  55                  60                  


Ser Leu Met His Leu Gln Leu Gly Glu Val Pro Thr Ile Val Val Ser 
65                  70                  75                  80  


Ser Pro Lys Trp Ala Lys Glu Ile Leu Thr Thr Tyr Asp Ile Thr Ser 
                85                  90                  95      


Ala Asn Arg Pro Glu Thr Leu Thr Gly Glu Ile Val Leu Tyr His Asn 
            100                 105                 110         


Thr Asp Val Val Leu Ala Pro Tyr Gly Glu Tyr Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Ile Cys Thr Leu Glu Leu Leu Ser Val Lys Lys Val Lys Ser Phe 
    130                 135                 140                 


Gln Ser Leu Arg Glu Glu Glu Cys Trp Asn Leu Val Gln Glu Ile Lys 
145                 150                 155                 160 


Ala Ser Gly Ser Gly Arg Pro Val Asn Leu Ser Glu Asn Val Phe Lys 
                165                 170                 175     


Leu Ile Ala Thr Ile Leu Ser Arg Ala Ala Phe Gly Lys Gly Ile Lys 
            180                 185                 190         


Asp Gln Lys Glu Leu Thr Glu Ile Val Lys Glu Ile Leu Arg Gln Thr 
        195                 200                 205             


Gly Gly Phe Asp Val Ala Asp Ile Phe Pro Ser Lys Lys Phe Leu His 
    210                 215                 220                 


His Leu Ser Gly Lys Arg Ala Arg Leu Thr Ser Leu Arg Lys Lys Ile 
225                 230                 235                 240 


Asp Asn Leu Ile Asp Asn Leu Val Ala Glu His Thr Val Asn Thr Ser 
                245                 250                 255     


Ser Lys Thr Asn Glu Thr Leu Leu Asp Val Leu Leu Arg Leu Lys Asp 
            260                 265                 270         


Ser Ala Glu Phe Pro Leu Thr Ser Asp Asn Ile Lys Ala Ile Ile Leu 
        275                 280                 285             


Asp Met Phe Gly Ala Gly Thr Asp Thr Ser Ser Ser Thr Ile Glu Trp 
    290                 295                 300                 


Ala Ile Ser Glu Leu Ile Lys Cys Pro Lys Ala Met Glu Lys Val Gln 
305                 310                 315                 320 


Ala Glu Leu Arg Lys Ala Leu Asn Gly Lys Glu Lys Ile His Glu Glu 
                325                 330                 335     


Asp Ile Gln Glu Leu Ser Tyr Leu Asn Met Val Ile Lys Glu Thr Leu 
            340                 345                 350         


Arg Leu His Pro Pro Leu Pro Leu Val Leu Pro Arg Glu Cys Arg Gln 
        355                 360                 365             


Pro Val Asn Leu Ala Gly Tyr Asn Ile Pro Asn Lys Thr Lys Leu Ile 
    370                 375                 380                 


Val Asn Val Phe Ala Ile Asn Arg Asp Pro Glu Tyr Trp Lys Asp Ala 
385                 390                 395                 400 


Glu Ala Phe Ile Pro Glu Arg Phe Glu Asn Ser Ser Ala Thr Val Met 
                405                 410                 415     


Gly Ala Glu Tyr Glu Tyr Leu Pro Phe Gly Ala Gly Arg Arg Met Cys 
            420                 425                 430         


Pro Gly Ala Ala Leu Gly Leu Ala Asn Val Gln Leu Pro Leu Ala Asn 
        435                 440                 445             


Ile Leu Tyr His Phe Asn Trp Lys Leu Pro Asn Gly Val Ser Tyr Asp 
    450                 455                 460                 


Gln Ile Asp Met Thr Glu Ser Ser Gly Ala Thr Met Gln Arg Lys Thr 
465                 470                 475                 480 


Glu Leu Leu Leu Val Pro Ser Phe 
                485             


<210>  20
<211>  1467
<212>  DNA
<213>  Artemisia annua

<400>  20
atggcactct cactgaccac ttccattgct cttgcaacga tccttttgtt cgtttacaag       60

ttcgctactc gttccaaatc caccaaaaaa agccttcctg agccatggcg acttcccatt      120

attggtcaca tgcatcactt gattggtaca acgccacatc gtggggttag ggatttagcc      180

agaaagtatg gatctttgat gcatttacag cttggtgaag ttccaacaat cgtggtgtca      240

tctccgaaat gggctaaaga gattttgaca acgtacgaca ttacctctgc taacaggccc      300

gagactttaa ctggtgagat tgttttatat cacaatacgg atgttgttct tgcaccttat      360

ggtgaatact ggaggcagtt acgtaaaatt tgcacattgg agcttttgag tgttaagaaa      420

gtaaagtcat ttcagtcgct tcgtgaagag gagtgttgga atttggttca agagattaaa      480

gcttcaggtt cagggagacc ggttaacctt tcagagaatg ttttcaagtt gattgcaacg      540

atacttagta gagccgcatt tgggaaaggg atcaaggacc agaaagagtt aacggagatt      600

gtgaaagaga tactgaggca aactggtggt tttgatgtgg cagatatctt tccttcaaag      660

aaatttcttc atcatctttc gggcaagaga gctcggttaa ctagccttcg caaaaagatc      720

gataatttaa tcgataacct tgtagctgag catactgtta acacctccag taaaactaac      780

gagacactcc tcgatgttct tttaaggctc aaagacagtg ctgaattccc attaacatct      840

gataacatta aagccatcat tttggatatg tttggagcag gcacagacac ttcctcatcc      900

acaatcgaat gggctatttc ggaactcata aagtgtccga aagcaatgga gaaagtacaa      960

gcggaattga ggaaagcatt gaacggaaaa gaaaagatcc atgaggaaga cattcaagaa     1020

ctaagctact tgaacatggt aatcaaagaa acattgaggt tgcaccctcc actacccttg     1080

gttctgccaa gagagtgccg ccaaccagtc aatttggctg gatacaacat acccaataag     1140

accaaactta ttgtcaacgt ctttgcgata aatagggacc ctgaatattg gaaagacgct     1200

gaagctttca tccctgaacg atttgaaaat agttctgcaa ctgtcatggg tgcagaatac     1260

gagtatcttc cgtttggagc tgggagaagg atgtgtcctg gagccgcact tggtttagct     1320

aacgtgcagc tcccgctcgc taatatacta tatcatttca actggaaact ccccaatggt     1380

gtgagctatg accagatcga catgaccgag agctctggag ccacgatgca aagaaagact     1440

gagttgttac tcgttccaag tttctag                                         1467


<210>  21
<211>  495
<212>  PRT
<213>  Artemisia annua

<400>  21

Met Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser Ile 
1               5                   10                  15      


Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Lys Phe Ala Thr Arg Ser 
            20                  25                  30          


Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile 
        35                  40                  45              


Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val Arg 
    50                  55                  60                  


Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly Glu 
65                  70                  75                  80  


Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Val Leu 
                85                  90                  95      


Thr Thr Tyr Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly 
            100                 105                 110         


Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly 
        115                 120                 125             


Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser 
    130                 135                 140                 


Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys Trp 
145                 150                 155                 160 


Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn 
                165                 170                 175     


Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala 
            180                 185                 190         


Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val 
        195                 200                 205             


Lys Glu Ile Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe 
    210                 215                 220                 


Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu 
225                 230                 235                 240 


Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala 
                245                 250                 255     


Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp 
            260                 265                 270         


Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp 
        275                 280                 285             


Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr 
    290                 295                 300                 


Ser Ser Ser Thr Ile Glu Trp Ala Ile Pro Glu Leu Ile Lys Cys Pro 
305                 310                 315                 320 


Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly 
                325                 330                 335     


Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn 
            340                 345                 350         


Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Val 
        355                 360                 365             


Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile 
    370                 375                 380                 


Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp 
385                 390                 395                 400 


Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu 
                405                 410                 415     


Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe 
            420                 425                 430         


Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn 
        435                 440                 445             


Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu 
    450                 455                 460                 


Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly 
465                 470                 475                 480 


Ala Thr Met Gln Arg Lys Ala Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495 


<210>  22
<211>  1488
<212>  DNA
<213>  Artemisia annua

<400>  22
atgaagagta tactaaaagc aatggctctc tcactgacca cttccattgc tcttgcaacg       60

atccttttgt tcgtttacaa gttcgctact cgttccaagt ccaccaaaaa aagccttcct      120

gagccatggc gacttcccat tattggtcac atgcatcact tgattggtac aacgccacat      180

cgtggggtta gggatttagc cagaaagtat ggatctttga tgcatttaca gcttggtgaa      240

gttccaacaa ttgtggtgtc atctccgaaa tgggctaaag aggttttgac aacgtacgac      300

attacctttg ctaacaggcc cgagacttta actggtgaga ttgttttata tcacaatacg      360

gatgttgttc ttgcacctta tggtgagtac tggaggcaat tacgtaaaat ttgcacattg      420

gagcttttga gtgttaagaa agtaaagtca tttcagtcgc ttcgtgaaga ggagtgttgg      480

aatttggttc aagagattaa agcttcaggt tcagggagac cggttaacct ttcagagaat      540

gttttcaagt tgattgcaac gatacttagt agagccgcat ttgggaaagg gatcaaggac      600

cagaaagagt taacggagat tgtgaaagag atactgaggc aaactggtgg ttttgatgtg      660

gcagatatct ttccttcaaa gaaatttctt catcatcttt cgggcaagag agctcggtta      720

actagccttc gcaaaaagat cgataattta atcgataacc ttgtagctga gcatactgtt      780

aacacctcca gtaaaactaa cgagacactc ctcgatgttc ttttaaggct caaagacagt      840

gctgaattcc cattaacatc tgataacatt aaagccatca ttttggatat gtttggagca      900

ggcacagaca cttcctcatc cacaatcgaa tgggcgattc cggaactcat aaagtgtccg      960

aaagcaatgg agaaagtaca agcggaattg aggaaagcat tgaacggaaa agaaaagatc     1020

catgaggaag acattcaaga actaagctac ttgaacatgg taatcaaaga aacattgagg     1080

ttgcaccctc cactaccctt ggttctgcca agagagtgcc gccaaccagt caatttggct     1140

ggatacaaca tacccaataa gaccaaactt attgtcaacg tctttgcgat aaatagggac     1200

cctgaatatt ggaaagacgc tgaagctttc atccctgaac gatttgaaaa tagttctgca     1260

actgtcatgg gtgcagaata cgagtatctt ccgtttggag ctgggagaag gatgtgtcct     1320

ggagccgcac ttggtttagc taacgtgcag ctcccgctcg ctaatatact atatcatttc     1380

aactggaaac tccccaatgg tgtgagctat gaccagatcg acatgaccga gagctctgga     1440

gccacgatgc aaagaaaggc tgagttgtta ctcgttccaa gtttctag                  1488


<210>  23
<211>  495
<212>  PRT
<213>  Artemisia annua

<400>  23

Met Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser Ile 
1               5                   10                  15      


Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Glu Phe Ala Thr Arg Ser 
            20                  25                  30          


Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile 
        35                  40                  45              


Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val Gly 
    50                  55                  60                  


Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly Glu 
65                  70                  75                  80  


Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile Leu 
                85                  90                  95      


Thr Thr Tyr Asp Ile Ser Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly 
            100                 105                 110         


Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly 
        115                 120                 125             


Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Ser Glu Leu Leu Ser 
    130                 135                 140                 


Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys Trp 
145                 150                 155                 160 


Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn 
                165                 170                 175     


Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala 
            180                 185                 190         


Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val 
        195                 200                 205             


Lys Glu Thr Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe 
    210                 215                 220                 


Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu 
225                 230                 235                 240 


Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala 
                245                 250                 255     


Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp 
            260                 265                 270         


Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp 
        275                 280                 285             


Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr 
    290                 295                 300                 


Ser Ser Ser Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Cys Pro 
305                 310                 315                 320 


Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly 
                325                 330                 335     


Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn 
            340                 345                 350         


Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Val 
        355                 360                 365             


Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile 
    370                 375                 380                 


Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp 
385                 390                 395                 400 


Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu 
                405                 410                 415     


Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe 
            420                 425                 430         


Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn 
        435                 440                 445             


Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu 
    450                 455                 460                 


Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly 
465                 470                 475                 480 


Ala Thr Met Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495 


<210>  24
<211>  1488
<212>  DNA
<213>  Artemisia annua

<400>  24
atgaagagta tactaaaagc aatggcactc tcactgacca cttccattgc tcttgcaacg       60

atccttttgt tcgtttacga gttcgctact cgttccaaat ccaccaaaaa aagccttcct      120

gagccatggc gacttcccat tattggtcac atgcatcact tgattggtac aacgccacat      180

cgtggggttg gggatttagc cagaaagtat ggatctttga tgcatttaca gcttggtgaa      240

gttccaacaa tcgtggtgtc atctccgaaa tgggctaaag agattttgac aacgtacgac      300

atttcctttg ctaacaggcc cgagacttta actggtgaga ttgttttata tcacaatacg      360

gatgttgttc ttgcacctta tggtgaatac tggaggcaat tacgtaaaat ttgcacatcg      420

gagcttttga gtgttaagaa agtaaagtca tttcagtcgc ttcgtgaaga ggagtgttgg      480

aatttggttc aagagattaa agcttcaggt tcagggagac cggttaacct ttcagagaat      540

gttttcaagt tgattgcaac gatacttagt agagccgcat ttgggaaagg gatcaaggac      600

cagaaagagt taacggagat tgtgaaagag acactgaggc aaactggtgg ttttgatgtg      660

gcagatatct ttccttcaaa gaaatttctt catcatcttt cgggcaagag agctcggtta      720

actagccttc gcaaaaagat cgataattta atcgataacc ttgtagctga gcatactgtt      780

aacacctcca gtaaaactaa cgagacactc ctcgatgttc ttttaaggct caaagacagt      840

gctgaattcc cattaacatc tgataacatt aaagccatca ttttggatat gtttggagca      900

ggcacagaca cttcctcatc cacaatcgaa tgggcgattt cggaactcat aaagtgtccg      960

aaagcaatgg agaaagtaca agcggaattg aggaaagcat tgaacggaaa agaaaagatc     1020

catgaggaag acattcaaga actaagctac ttgaacatgg taatcaaaga aacattgagg     1080

ttgcaccctc cactaccctt ggttctgcca agagagtgcc gccaaccagt caatttggct     1140

ggatacaaca tacccaataa gaccaaactt attgtcaacg tctttgcgat aaatagggac     1200

cctgaatatt ggaaagacgc tgaagctttc atccctgaac gatttgaaaa tagttctgca     1260

actgtcatgg gtgcagaata cgagtatctt ccgtttggag ctgggagaag gatgtgtcct     1320

ggagccgcac ttggtttagc taacgtgcag ctcccgctcg ctaatatact atatcatttc     1380

aactggaaac tccccaatgg tgtgagctat gaccagatcg acatgaccga gagctctgga     1440

gccacgatgc aaagaaagac tgagttgtta ctcgttccaa gtttctag                  1488


<210>  25
<211>  495
<212>  PRT
<213>  Artemisia annua

<400>  25

Met Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser Ile 
1               5                   10                  15      


Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Lys Phe Ala Thr Arg Ser 
            20                  25                  30          


Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile 
        35                  40                  45              


Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val Arg 
    50                  55                  60                  


Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly Glu 
65                  70                  75                  80  


Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile Leu 
                85                  90                  95      


Thr Thr Tyr Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly 
            100                 105                 110         


Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly 
        115                 120                 125             


Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser 
    130                 135                 140                 


Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys Trp 
145                 150                 155                 160 


Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn 
                165                 170                 175     


Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala 
            180                 185                 190         


Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val 
        195                 200                 205             


Lys Glu Ile Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe 
    210                 215                 220                 


Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu 
225                 230                 235                 240 


Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala 
                245                 250                 255     


Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp 
            260                 265                 270         


Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp 
        275                 280                 285             


Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr 
    290                 295                 300                 


Ser Ser Ser Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Cys Pro 
305                 310                 315                 320 


Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly 
                325                 330                 335     


Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn 
            340                 345                 350         


Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Val 
        355                 360                 365             


Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile 
    370                 375                 380                 


Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp 
385                 390                 395                 400 


Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu 
                405                 410                 415     


Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe 
            420                 425                 430         


Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn 
        435                 440                 445             


Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu 
    450                 455                 460                 


Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly 
465                 470                 475                 480 


Ala Thr Met Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495 


<210>  26
<211>  1488
<212>  DNA
<213>  Artemisia annua

<400>  26
atgaagagta tactaaaagc aatggcactc tcactgacca cttccattgc tcttgcaacg       60

atccttttgt tcgtttacaa gttcgctact cgttccaaat ccaccaaaaa aagccttcct      120

gagccatggc ggcttcccat tattggtcac atgcatcact tgattggtac aacgccacat      180

cgtggggtta gggatttagc cagaaagtat ggatctttga tgcatttaca gcttggtgaa      240

gttccaacaa tcgtggtgtc atctccgaaa tgggctaaag agattttgac aacgtacgac      300

attacctttg ctaacaggcc cgagacttta actggtgaga ttgttttata tcacaatacg      360

gatgttgttc ttgcacctta tggtgaatac tggaggcaat tacgtaaaat ttgcacattg      420

gagcttttga gtgttaagaa agtaaagtca tttcagtcac ttcgtgaaga ggagtgttgg      480

aatttggttc aagagattaa agcttcaggt tcagggagac cggttaacct ttcagagaat      540

gttttcaagt tgattgcaac gatacttagt agagccgcat ttgggaaagg gatcaaggac      600

cagaaagagt taacggagat tgtgaaagag atactgaggc aaactggtgg ttttgatgtg      660

gcagatatct ttccttcaaa gaaatttctt catcatcttt cgggcaagag agctcggtta      720

actagccttc gcaaaaagat cgataattta atcgataacc ttgtagctga gcatactgtt      780

aacacctcca gtaaaactaa cgagacactc ctcgatgttc ttttaaggct caaagacagt      840

gctgaattcc cattaacatc tgataacatt aaagccatca ttttggatat gtttggagca      900

ggcacagaca cttcctcatc cacaatcgaa tgggcgattt cggaactcat aaagtgtccg      960

aaagcaatgg agaaagtaca agcggaattg aggaaagcat tgaacggaaa agaaaagatc     1020

catgaggaag acattcaaga actaagctac ttgaacatgg taatcaaaga aacattgagg     1080

ttgcaccctc cactaccctt ggttctgcca agagagtgcc gccaaccagt caatttggct     1140

ggatacaaca tacccaataa gaccaaactt attgtcaacg tctttgcgat aaatagggac     1200

cctgaatatt ggaaagacgc tgaagctttc atccctgaac gatttgaaaa tagttctgca     1260

actgtcatgg gtgcagaata cgagtatctt ccgtttggag ctgggagaag gatgtgtcct     1320

ggagccgcac ttggtttagc taacgtgcag ctcccgctcg ctaatatact atatcatttc     1380

aactggaaac tccccaatgg tgtgagctat gaccagatcg acatgaccga gagctctgga     1440

gccacgatgc aaagaaagac tgagttgtta ctcgttccaa gtttctag                  1488


<210>  27
<211>  495
<212>  PRT
<213>  Artemisia annua

<400>  27

Met Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser Ile 
1               5                   10                  15      


Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Lys Phe Ala Thr Arg Ser 
            20                  25                  30          


Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile 
        35                  40                  45              


Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val Arg 
    50                  55                  60                  


Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly Glu 
65                  70                  75                  80  


Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile Leu 
                85                  90                  95      


Thr Thr Tyr Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly 
            100                 105                 110         


Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly 
        115                 120                 125             


Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser 
    130                 135                 140                 


Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys Trp 
145                 150                 155                 160 


Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn 
                165                 170                 175     


Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala 
            180                 185                 190         


Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val 
        195                 200                 205             


Lys Glu Ile Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe 
    210                 215                 220                 


Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu 
225                 230                 235                 240 


Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala 
                245                 250                 255     


Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp 
            260                 265                 270         


Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp 
        275                 280                 285             


Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr 
    290                 295                 300                 


Ser Ser Ser Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Cys Pro 
305                 310                 315                 320 


Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly 
                325                 330                 335     


Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn 
            340                 345                 350         


Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Val 
        355                 360                 365             


Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile 
    370                 375                 380                 


Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp 
385                 390                 395                 400 


Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu 
                405                 410                 415     


Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe 
            420                 425                 430         


Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn 
        435                 440                 445             


Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu 
    450                 455                 460                 


Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly 
465                 470                 475                 480 


Ala Thr Met Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495 


<210>  28
<211>  1488
<212>  DNA
<213>  Artemisia annua

<400>  28
atgaagtcaa ttttaaaggc tatggcacta tctttaacta catcaattgc tttagcaact       60

attttgttgt tcgtgtacaa atttgccact agaagtaagt caactaaaaa gtccttgccg      120

gaaccttgga ggctacccat cattggtcac atgcaccatt tgatcggaac cacaccacac      180

aggggtgtaa gggatttagc gagaaaatat ggttcgctaa tgcaccttca attgggagag      240

gtacccacaa tagtcgtgtc gagtcctaag tgggctaagg aaattcttac aacctacgat      300

attactttcg ctaatagacc cgaaacttta actggggaaa tagttttata tcataacact      360

gatgttgtcc ttgctccata tggggaatac tggagacaat taaggaagat ttgtactctt      420

gaattgttgt ctgtaaaaaa ggttaagtca tttcaatcgt tgagggaaga agaatgttgg      480

aatttagtcc aggaaataaa ggcttcaggt agtggtagac cagtaaattt aagtgaaaac      540

gtttttaaac taattgccac tatactatcc cgtgctgcgt ttggtaaggg aattaaagat      600

caaaaggaac ttactgaaat tgttaaagaa atactgagac aaacaggcgg tttcgatgtt      660

gccgatattt tcccatctaa aaagttcttg catcacttga gcggtaagag agcaagatta      720

actagcctac gtaaaaagat tgataactta attgacaatt tggtagctga acataccgta      780

aatacgtcat ccaaaaccaa cgaaacccta ttagatgtat tacttagatt aaaggattct      840

gctgagtttc ctctgacttc ggataatatc aaagcaataa ttttggacat gttcggtgca      900

gggaccgaca cttcaagttc taccatagaa tgggctataa gcgagctaat aaaatgtccg      960

aaagcaatgg aaaaggttca ggctgaatta cgtaaggcct tgaatgggaa agaaaaaata     1020

catgaagaag atatacaaga attgtcctac ttgaatatgg tcatcaaaga gactcttaga     1080

ctacacccac ccttgccgtt agtgctacct agagaatgtc gtcagccagt aaacttggct     1140

ggttataata tccctaacaa aacgaaatta atcgttaatg tgtttgcgat caatagagat     1200

cctgaatact ggaaggatgc agaagcgttt atacctgaaa gatttgaaaa ctcttcggca     1260

acagtgatgg gcgccgaata tgaatattta ccatttgggg ctggacgtcg tatgtgtcct     1320

ggcgctgcgt taggtttggc caatgttcaa ctgccactag ccaacattct ttatcatttc     1380

aactggaagt tgcccaatgg agtttcatat gatcaaattg acatgacgga aagttcaggt     1440

gcaacaatgc aacgtaaaac agaattgcta ttggtcccta gtttttaa                  1488


<210>  29
<211>  2043
<212>  DNA
<213>  Homo sapiens

<400>  29
atgatcaaca tgggagactc ccacgtggac accagctcca ccgtgtccga ggcggtggcc       60

gaagaagtat ctcttttcag catgacggac atgattctgt tttcgctcat cgtgggtctc      120

ctaacctact ggttcctctt cagaaagaaa aaagaagaag tccccgagtt caccaaaatt      180

cagacattga cctcctctgt cagagagagc agctttgtgg aaaagatgaa gaaaacgggg      240

aggaacatca tcgtgttcta cggctcccag acggggactg cagaggagtt tgccaaccgc      300

ctgtccaagg acgcccaccg ctacgggatg cgaggcatgt cagcggaccc tgaggagtat      360

gacctggccg acctgagcag cctgccagag atcgacaacg ccctggtggt tttctgcatg      420

gccacctacg gtgagggaga ccccaccgac aatgcccagg acttctacga ctggctgcag      480

gagacagacg tggatctctc tggggtcaag ttcgcggtgt ttggtcttgg gaacaagacc      540

tacgagcact tcaatgccat gggcaagtac gtggacaagc ggctggagca gctcggcgcc      600

cagcgcatct ttgagctggg gttgggcgac gacgatggga acttggagga ggacttcatc      660

acctggcgag agcagttctg gccggccgtg tgtgaacact ttggggtgga agccactggc      720

gaggagtcca gcattcgcca gtacgagctt gtggtccaca ccgacataga tgcggccaag      780

gtgtacatgg gggagatggg ccggctgaag agctacgaga accagaagcc cccctttgat      840

gccaagaatc cgttcctggc tgcagtcacc accaaccgga agctgaacca gggaaccgag      900

cgccacctca tgcacctgga attggacatc tcggactcca aaatcaggta tgaatctggg      960

gaccacgtgg ctgtgtaccc agccaacgac tctgctctcg tcaaccagct gggcaaaatc     1020

ctgggtgccg acctggacgt cgtcatgtcc ctgaacaacc tggatgagga gtccaacaag     1080

aagcacccat tcccgtgccc tacgtcctac cgcacggccc tcacctacta cctggacatc     1140

accaacccgc cgcgtaccaa cgtgctgtac gagctggcgc agtacgcctc ggagccctcg     1200

gagcaggagc tgctgcgcaa gatggcctcc tcctccggcg agggcaagga gctgtacctg     1260

agctgggtgg tggaggcccg gaggcacatc ctggccatcc tgcaggactg cccgtccctg     1320

cggcccccca tcgaccacct gtgtgagctg ctgccgcgcc tgcaggcccg ctactactcc     1380

atcgcctcat cctccaaggt ccaccccaac tctgtgcaca tctgtgcggt ggttgtggag     1440

tacgagacca aggctggccg catcaacaag ggcgtggcca ccaactggct gcgggccaag     1500

gagcctgccg gggagaacgg cggccgtgcg ctggtgccca tgttcgtgcg caagtcccag     1560

ttccgcctgc ccttcaaggc caccacgcct gtcatcatgg tgggccccgg caccggggtg     1620

gcacccttca taggcttcat ccaggagcgg gcctggctgc gacagcaggg caaggaggtg     1680

ggggagacgc tgctgtacta cggctgccgc cgctcggatg aggactacct gtaccgggag     1740

gagctggcgc agttccacag ggacggtgcg ctcacccagc tcaacgtggc cttctcccgg     1800

gagcagtccc acaaggtcta cgtccagcac ctgctaaagc aagaccgaga gcacctgtgg     1860

aagttgatcg aaggcggtgc ccacatctac gtctgtgggg atgcacggaa catggccagg     1920

gatgtgcaga acaccttcta cgacatcgtg gctgagctcg gggccatgga gcacgcgcag     1980

gcggtggact acatcaagaa actgatgacc aagggccgct actccctgga cgtgtggagc     2040

tag                                                                   2043


<210>  30
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val Ser 
1               5                   10                  15      


Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met Ile 
            20                  25                  30          


Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe Arg 
        35                  40                  45              


Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu Thr 
    50                  55                  60                  


Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly 
65                  70                  75                  80  


Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu 
                85                  90                  95      


Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly 
            100                 105                 110         


Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu 
        115                 120                 125             


Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr Gly 
    130                 135                 140                 


Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly Leu 
                165                 170                 175     


Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp 
            180                 185                 190         


Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu 
        195                 200                 205             


Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu 
    210                 215                 220                 


Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr Gly 
225                 230                 235                 240 


Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp Ile 
                245                 250                 255     


Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser Tyr 
            260                 265                 270         


Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala 
        275                 280                 285             


Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met 
    290                 295                 300                 


His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly 
305                 310                 315                 320 


Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln 
                325                 330                 335     


Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu Asn 
            340                 345                 350         


Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr 
        355                 360                 365             


Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro 
    370                 375                 380                 


Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser 
385                 390                 395                 400 


Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly Lys 
                405                 410                 415     


Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala 
            420                 425                 430         


Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys 
        435                 440                 445             


Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser 
    450                 455                 460                 


Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val Glu 
465                 470                 475                 480 


Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn Trp 
                485                 490                 495     


Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly Gly Arg Ala Leu Val 
            500                 505                 510         


Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala Thr 
        515                 520                 525             


Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Ile 
    530                 535                 540                 


Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu Val 
545                 550                 555                 560 


Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr 
                565                 570                 575     


Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu Thr 
            580                 585                 590         


Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr Val 
        595                 600                 605             


Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile Glu 
    610                 615                 620                 


Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Arg 
625                 630                 635                 640 


Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala Met 
                645                 650                 655     


Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys Gly 
            660                 665                 670         


Arg Tyr Ser Leu Asp Val Trp Ser 
        675                 680 


<210>  31
<211>  704
<212>  PRT
<213>  Artemisia annua

<400>  31

Met Gln Ser Thr Thr Ser Val Lys Leu Ser Pro Phe Asp Leu Met Thr 
1               5                   10                  15      


Ala Leu Leu Asn Gly Lys Val Ser Phe Asp Thr Ser Asn Thr Ser Asp 
            20                  25                  30          


Thr Asn Ile Pro Leu Ala Val Phe Met Glu Asn Arg Glu Leu Leu Met 
        35                  40                  45              


Ile Leu Thr Thr Ser Val Ala Val Leu Ile Gly Cys Val Val Val Leu 
    50                  55                  60                  


Val Trp Arg Arg Ser Ser Ser Ala Ala Lys Lys Ala Ala Glu Ser Pro 
65                  70                  75                  80  


Val Ile Val Val Pro Lys Lys Val Thr Glu Asp Glu Val Asp Asp Gly 
                85                  90                  95      


Arg Lys Lys Val Thr Val Phe Phe Gly Thr Gln Thr Gly Thr Ala Glu 
            100                 105                 110         


Gly Phe Ala Lys Ala Leu Val Glu Glu Ala Lys Ala Arg Tyr Glu Lys 
        115                 120                 125             


Ala Val Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Glu Asp Asp 
    130                 135                 140                 


Glu Tyr Glu Glu Lys Leu Lys Lys Glu Ser Leu Ala Phe Phe Phe Leu 
145                 150                 155                 160 


Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe Tyr 
                165                 170                 175     


Lys Trp Phe Thr Glu Gly Glu Glu Lys Gly Glu Trp Leu Asp Lys Leu 
            180                 185                 190         


Gln Tyr Ala Val Phe Gly Leu Gly Asn Arg Gln Tyr Glu His Phe Asn 
        195                 200                 205             


Lys Ile Ala Lys Val Val Asp Glu Lys Leu Val Glu Gln Gly Ala Lys 
    210                 215                 220                 


Arg Leu Val Pro Val Gly Met Gly Asp Asp Asp Gln Cys Ile Glu Asp 
225                 230                 235                 240 


Asp Phe Thr Ala Trp Lys Glu Leu Val Trp Pro Glu Leu Asp Gln Leu 
                245                 250                 255     


Leu Arg Asp Glu Asp Asp Thr Ser Val Ala Thr Pro Tyr Thr Ala Ala 
            260                 265                 270         


Val Ala Glu Tyr Arg Val Val Phe His Asp Lys Pro Glu Thr Tyr Asp 
        275                 280                 285             


Gln Asp Gln Leu Thr Asn Gly His Ala Val His Asp Ala Gln His Pro 
    290                 295                 300                 


Cys Arg Ser Asn Val Ala Val Lys Lys Glu Leu His Ser Pro Leu Ser 
305                 310                 315                 320 


Asp Arg Ser Cys Thr His Leu Glu Phe Asp Ile Ser Asn Thr Gly Leu 
                325                 330                 335     


Ser Tyr Glu Thr Gly Asp His Val Gly Val Tyr Val Glu Asn Leu Ser 
            340                 345                 350         


Glu Val Val Asp Glu Ala Glu Lys Leu Ile Gly Leu Pro Pro His Thr 
        355                 360                 365             


Tyr Phe Ser Val His Ala Asp Asn Glu Asp Gly Thr Pro Leu Gly Gly 
    370                 375                 380                 


Ala Ser Leu Pro Pro Pro Phe Pro Pro Cys Thr Leu Arg Lys Ala Leu 
385                 390                 395                 400 


Ala Ser Tyr Ala Asp Val Leu Ser Ser Pro Lys Lys Ser Ala Leu Leu 
                405                 410                 415     


Ala Leu Ala Ala His Ala Thr Asp Ser Thr Glu Ala Asp Arg Leu Lys 
            420                 425                 430         


Phe Leu Ala Ser Pro Ala Gly Lys Asp Glu Tyr Ala Gln Trp Ile Val 
        435                 440                 445             


Ala Ser His Arg Ser Leu Leu Glu Val Met Glu Ala Phe Pro Ser Ala 
    450                 455                 460                 


Lys Pro Pro Leu Gly Val Phe Phe Ala Ser Val Ala Pro Arg Leu Gln 
465                 470                 475                 480 


Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Phe Ala Pro Asn Arg 
                485                 490                 495     


Ile His Val Thr Cys Ala Leu Val Tyr Glu Gln Thr Pro Ser Gly Arg 
            500                 505                 510         


Val His Lys Gly Val Cys Ser Thr Trp Met Lys Asn Ala Val Pro Met 
        515                 520                 525             


Thr Glu Ser Gln Asp Cys Ser Trp Ala Pro Ile Tyr Val Arg Thr Ser 
    530                 535                 540                 


Asn Phe Arg Leu Pro Ser Asp Pro Lys Val Pro Val Ile Met Ile Gly 
545                 550                 555                 560 


Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln Glu Arg Leu 
                565                 570                 575     


Ala Gln Lys Glu Ala Gly Thr Glu Leu Gly Thr Ala Ile Leu Phe Phe 
            580                 585                 590         


Gly Cys Arg Asn Arg Lys Val Asp Phe Ile Tyr Glu Asp Glu Leu Asn 
        595                 600                 605             


Asn Phe Val Glu Thr Gly Ala Leu Ser Glu Leu Val Thr Ala Phe Ser 
    610                 615                 620                 


Arg Glu Gly Ala Thr Lys Glu Tyr Val Gln His Lys Met Thr Gln Lys 
625                 630                 635                 640 


Ala Ser Asp Ile Trp Asn Leu Leu Ser Glu Gly Ala Tyr Leu Tyr Val 
                645                 650                 655     


Cys Gly Asp Ala Lys Gly Met Ala Lys Asp Val His Arg Thr Leu His 
            660                 665                 670         


Thr Ile Val Gln Glu Gln Gly Ser Leu Asp Ser Ser Lys Ala Glu Leu 
        675                 680                 685             


Tyr Val Lys Asn Leu Gln Met Ala Gly Arg Tyr Leu Arg Asp Val Trp 
    690                 695                 700                 


<210>  32
<211>  2115
<212>  DNA
<213>  Artemisia annua

<400>  32
atgcaatcaa caacttccgt taagttatct cccttcgatc taatgacggc gttacttaac       60

ggcaaggtat cgttcgacac atcaaacaca tcggatacga atattccgtt agcggtgttt      120

atggagaatc gtgagctttt gatgatttta actacttcgg ttgcggtttt gatcggatgc      180

gttgtggtgc ttgtgtggag acggtcgtcg tcggcggcga agaaagcggc ggagtcgccg      240

gtgattgttg tgccgaagaa agtgacggag gatgaggttg atgatggacg gaagaaagtt      300

actgtgtttt ttggaactca gactggtact gctgaaggtt ttgctaaggc gcttgttgaa      360

gaagctaaag cgcgatatga aaaggcggtg tttaaagtga ttgatttgga tgattatgct      420

gctgaggacg atgagtatga ggagaagtta aagaaagaat ctcttgcttt tttcttttta      480

gctacgtatg gagatggtga gccgacagat aatgctgcta gattctataa atggtttacc      540

gagggtgaag agaaaggtga atggcttgac aagcttcaat acgcagtgtt tggacttggt      600

aacagacagt atgagcattt caacaagatt gcgaaggtgg tcgatgaaaa acttgtggag      660

cagggtgcaa agcgccttgt tcctgttggc atgggagacg atgatcaatg tattgaagac      720

gacttcactg catggaaaga gttggtgtgg cctgagttgg atcaattact tcgtgatgag      780

gatgatacat ctgttgccac tccatacaca gctgctgttg cagaataccg tgttgtgttc      840

catgataaac cagagacata tgatcaggat caactgacaa atggccatgc tgttcatgat      900

gctcaacatc catgcagatc caatgtcgct gtcaaaaagg agctccattc ccctctatct      960

gaccggtctt gcactcattt ggaatttgat atctctaata ctggattatc gtatgaaact     1020

ggggaccatg ttggagtcta cgttgagaat ctaagtgaag ttgtggacga agctgaaaaa     1080

ttaataggtt taccgccgca cacttatttc tcagtacacg ctgataacga agacgggaca     1140

ccacttggtg gagcctcttt gccacctcct ttccctccat gcactttaag aaaagcattg     1200

gcttcctatg ccgatgtttt gagctctcct aaaaagtcag ctttgcttgc tttagctgct     1260

catgctactg attctactga agctgataga ctgaaatttc ttgcgtctcc tgcgggaaag     1320

gatgaatatg ctcagtggat agttgcaagc cacagaagtc tccttgaggt catggaggcc     1380

ttcccatcag ctaagcctcc gcttggtgtt ttttttgcat ctgtcgcccc acgtttgcag     1440

ccgagatact attccatttc ttcttcccca aggtttgcgc caaataggat tcatgtaact     1500

tgtgcattag tgtatgagca aacaccatca ggccgcgttc acaagggagt ctgttcaaca     1560

tggatgaaga atgccgtgcc tatgacagaa agccaggatt gcagttgggc cccaatttat     1620

gttagaacat ccaatttcag acttccttct gatcctaagg tcccagttat catgattggc     1680

ccaggcactg gattggctcc atttagaggt ttccttcagg aaaggttagc tcagaaggaa     1740

gctgggactg agctcggaac agccatctta ttcttcggat gcaggaatcg caaagtggat     1800

ttcatatatg aggacgagct taataatttc gtggagactg gggctctttc cgagcttgtt     1860

acggccttct ctcgtgaagg tgccactaag gagtacgtgc aacacaagat gactcagaag     1920

gcttcggata tctggaattt actctctgag ggagcatatt tgtatgtttg cggtgatgcc     1980

aaaggcatgg ccaaagatgt acatcggact ctgcacacta ttgtgcaaga acagggatct     2040

ctagactcct caaaggcgga gctctacgtg aagaatctac aaatggcagg aagatatctc     2100

cgtgatgtat ggtaa                                                      2115


<210>  33
<211>  1045
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Ser Leu Pro Leu Lys Thr Ile Val His Leu Val Lys Pro Phe Ala 
1               5                   10                  15      


Cys Thr Ala Arg Phe Ser Ala Arg Tyr Pro Ile His Val Ile Val Val 
            20                  25                  30          


Ala Val Leu Leu Ser Ala Ala Ala Tyr Leu Ser Val Thr Gln Ser Tyr 
        35                  40                  45              


Leu Asn Glu Trp Lys Leu Asp Ser Asn Gln Tyr Ser Thr Tyr Leu Ser 
    50                  55                  60                  


Ile Lys Pro Asp Glu Leu Phe Glu Lys Cys Thr His Tyr Tyr Arg Ser 
65                  70                  75                  80  


Pro Val Ser Asp Thr Trp Lys Leu Leu Ser Ser Lys Glu Ala Ala Asp 
                85                  90                  95      


Ile Tyr Thr Pro Phe His Tyr Tyr Leu Ser Thr Ile Ser Phe Gln Ser 
            100                 105                 110         


Lys Asp Asn Ser Thr Thr Leu Pro Ser Leu Asp Asp Val Ile Tyr Ser 
        115                 120                 125             


Val Asp His Thr Arg Tyr Leu Leu Ser Glu Glu Pro Lys Ile Pro Thr 
    130                 135                 140                 


Glu Leu Val Ser Glu Asn Gly Thr Lys Trp Arg Leu Arg Asn Asn Ser 
145                 150                 155                 160 


Asn Phe Ile Leu Asp Leu His Asn Ile Tyr Arg Asn Met Val Lys Gln 
                165                 170                 175     


Phe Ser Asn Lys Thr Ser Glu Phe Asp Gln Phe Asp Leu Phe Ile Ile 
            180                 185                 190         


Leu Ala Ala Tyr Leu Thr Leu Phe Tyr Thr Leu Cys Cys Leu Phe Asn 
        195                 200                 205             


Asp Met Arg Lys Ile Gly Ser Lys Phe Trp Leu Ser Phe Ser Ala Leu 
    210                 215                 220                 


Ser Asn Ser Ala Cys Ala Leu Tyr Leu Ser Leu Tyr Thr Thr His Ser 
225                 230                 235                 240 


Leu Leu Lys Lys Pro Ala Ser Leu Leu Ser Leu Val Ile Gly Leu Pro 
                245                 250                 255     


Phe Ile Val Val Ile Ile Gly Phe Lys His Lys Val Arg Leu Ala Ala 
            260                 265                 270         


Phe Ser Leu Gln Lys Phe His Arg Ile Ser Ile Asp Lys Lys Ile Thr 
        275                 280                 285             


Val Ser Asn Ile Ile Tyr Glu Ala Met Phe Gln Glu Gly Ala Tyr Leu 
    290                 295                 300                 


Ile Arg Asp Tyr Leu Phe Tyr Ile Ser Ser Phe Ile Gly Cys Ala Ile 
305                 310                 315                 320 


Tyr Ala Arg His Leu Pro Gly Leu Val Asn Phe Cys Ile Leu Ser Thr 
                325                 330                 335     


Phe Met Leu Val Phe Asp Leu Leu Leu Ser Ala Thr Phe Tyr Ser Ala 
            340                 345                 350         


Ile Leu Ser Met Lys Leu Glu Ile Asn Ile Ile His Arg Ser Thr Val 
        355                 360                 365             


Ile Arg Gln Thr Leu Glu Glu Asp Gly Val Val Pro Thr Thr Ala Asp 
    370                 375                 380                 


Ile Ile Tyr Lys Asp Glu Thr Ala Ser Glu Pro His Phe Leu Arg Ser 
385                 390                 395                 400 


Asn Val Ala Ile Ile Leu Gly Lys Ala Ser Val Ile Gly Leu Leu Leu 
                405                 410                 415     


Leu Ile Asn Leu Tyr Val Phe Thr Asp Lys Leu Asn Ala Thr Ile Leu 
            420                 425                 430         


Asn Thr Val Tyr Phe Asp Ser Thr Ile Tyr Ser Leu Pro Asn Phe Ile 
        435                 440                 445             


Asn Tyr Lys Asp Ile Gly Asn Leu Ser Asn Gln Val Ile Ile Ser Val 
    450                 455                 460                 


Leu Pro Lys Gln Tyr Tyr Thr Pro Leu Lys Lys Tyr His Gln Ile Glu 
465                 470                 475                 480 


Asp Ser Val Leu Leu Ile Ile Asp Ser Val Ser Asn Ala Ile Arg Asp 
                485                 490                 495     


Gln Phe Ile Ser Lys Leu Leu Phe Phe Ala Phe Ala Val Ser Ile Ser 
            500                 505                 510         


Ile Asn Val Tyr Leu Leu Asn Ala Ala Lys Ile His Thr Gly Tyr Met 
        515                 520                 525             


Asn Phe Gln Pro Gln Ser Asn Lys Ile Asp Asp Leu Val Val Gln Gln 
    530                 535                 540                 


Lys Ser Ala Thr Ile Glu Phe Ser Glu Thr Arg Ser Met Pro Ala Ser 
545                 550                 555                 560 


Ser Gly Leu Glu Thr Pro Val Thr Ala Lys Asp Ile Ile Ile Ser Glu 
                565                 570                 575     


Glu Ile Gln Asn Asn Glu Cys Val Tyr Ala Leu Ser Ser Gln Asp Glu 
            580                 585                 590         


Pro Ile Arg Pro Leu Ser Asn Leu Val Glu Leu Met Glu Lys Glu Gln 
        595                 600                 605             


Leu Lys Asn Met Asn Asn Thr Glu Val Ser Asn Leu Val Val Asn Gly 
    610                 615                 620                 


Lys Leu Pro Leu Tyr Ser Leu Glu Lys Lys Leu Glu Asp Thr Thr Arg 
625                 630                 635                 640 


Ala Val Leu Val Arg Arg Lys Ala Leu Ser Thr Leu Ala Glu Ser Pro 
                645                 650                 655     


Ile Leu Val Ser Glu Lys Leu Pro Phe Arg Asn Tyr Asp Tyr Asp Arg 
            660                 665                 670         


Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr Met Pro Ile Pro 
        675                 680                 685             


Val Gly Val Ile Gly Pro Leu Ile Ile Asp Gly Thr Ser Tyr His Ile 
    690                 695                 700                 


Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Ala Met Arg Gly 
705                 710                 715                 720 


Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr Val Leu Thr Lys 
                725                 730                 735     


Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro Thr Leu Ile Arg 
            740                 745                 750         


Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln Asn Ser 
        755                 760                 765             


Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu Gln His 
    770                 775                 780                 


Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met Arg Phe Arg Thr 
785                 790                 795                 800 


Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly Val Glu 
                805                 810                 815     


Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp Glu Asp Met Glu 
            820                 825                 830         


Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro Ala Ala 
        835                 840                 845             


Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu Ala Thr 
    850                 855                 860                 


Ile Pro Gly Asp Val Val Lys Ser Val Leu Lys Ser Asp Val Ser Ala 
865                 870                 875                 880 


Leu Val Glu Leu Asn Ile Ser Lys Asn Leu Val Gly Ser Ala Met Ala 
                885                 890                 895     


Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn Leu Val Thr Ala 
            900                 905                 910         


Leu Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn Val Glu Ser Ser 
        915                 920                 925             


Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp Leu Arg Ile Ser 
    930                 935                 940                 


Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly Gly Thr Val 
945                 950                 955                 960 


Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly Val Arg Gly Pro 
                965                 970                 975     


His Pro Thr Glu Pro Gly Ala Asn Ala Arg Gln Leu Ala Arg Ile Ile 
            980                 985                 990         


Ala Cys Ala Val Leu Ala Gly Glu  Leu Ser Leu Cys Ser  Ala Leu Ala 
        995                 1000                 1005             


Ala Gly  His Leu Val Gln Ser  His Met Thr His Asn  Arg Lys Thr 
    1010                 1015                 1020             


Asn Lys  Ala Asn Glu Leu Pro  Gln Pro Ser Asn Lys  Gly Pro Pro 
    1025                 1030                 1035             


Cys Lys  Thr Ser Ala Leu Leu  
    1040                 1045 


<210>  34
<211>  3138
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  34
atgtcacttc ccttaaaaac gatagtacat ttggtaaagc cctttgcttg cactgctagg       60

tttagtgcga gatacccaat ccacgtcatt gttgttgctg ttttattgag tgccgctgct      120

tatctatccg tgacacaatc ttaccttaac gaatggaagc tggactctaa tcagtattct      180

acatacttaa gcataaagcc ggatgagttg tttgaaaaat gcacacacta ctataggtct      240

cctgtgtctg atacatggaa gttactcagc tctaaagaag ccgccgatat ttatacccct      300

tttcattatt atttgtctac cataagtttt caaagtaagg acaattcaac gactttgcct      360

tcccttgatg acgttattta cagtgttgac cataccaggt acttattaag tgaagagcca      420

aagataccaa ctgaactagt gtctgaaaac ggaacgaaat ggagattgag aaacaacagc      480

aattttattt tggacctgca taatatttac cgaaatatgg tgaagcaatt ttctaacaaa      540

acgagcgaat ttgatcagtt cgatttgttt atcatcctag ctgcttacct tactcttttt      600

tatactctct gttgcctgtt taatgacatg aggaaaatcg gatcaaagtt ttggttaagc      660

ttttctgctc tttcaaactc tgcatgcgca ttatatttat cgctgtacac aactcacagt      720

ttattgaaga aaccggcttc cttattaagt ttggtcattg gactaccatt tatcgtagta      780

attattggct ttaagcataa agttcgactt gcggcattct cgctacaaaa attccacaga      840

attagtattg acaagaaaat aacggtaagc aacattattt atgaggctat gtttcaagaa      900

ggtgcctact taatccgcga ctacttattt tatattagct ccttcattgg atgtgctatt      960

tatgctagac atcttcccgg attggtcaat ttctgtattt tgtctacatt tatgctagtt     1020

ttcgacttgc ttttgtctgc tactttttat tctgccattt tatcaatgaa gctggaaatt     1080

aacatcattc acagatcaac cgtcatcaga cagactttgg aagaggacgg agttgtccca     1140

actacagcag atattatata taaggatgaa actgcctcag aaccacattt tttgagatct     1200

aacgtggcta tcattctggg aaaagcatca gttattggtc ttttgcttct gatcaacctt     1260

tatgttttca cagataagtt aaatgctaca atactaaaca cggtatattt tgactctaca     1320

atttactcgt taccaaattt tatcaattat aaagatattg gcaatctcag caatcaagtg     1380

atcatttccg tgttgccaaa gcaatattat actccgctga aaaaatacca tcagatcgaa     1440

gattctgttc tacttatcat tgattccgtt agcaatgcta ttcgggacca atttatcagc     1500

aagttacttt tttttgcatt tgcagttagt atttccatca atgtctactt actgaatgct     1560

gcaaaaattc acacaggata catgaacttc caaccacaat caaataagat cgatgatctt     1620

gttgttcagc aaaaatcggc aacgattgag ttttcagaaa ctcgaagtat gcctgcttct     1680

tctggcctag aaactccagt gaccgcgaaa gatataatta tctctgaaga aatccagaat     1740

aacgaatgcg tctatgcttt gagttcccag gacgagccta tccgtccttt atcgaattta     1800

gtggaactta tggagaaaga acaattaaag aacatgaata atactgaggt ttcgaatctt     1860

gtcgtcaacg gtaaactgcc attatattcc ttagagaaaa aattagagga cacaactcgt     1920

gcggttttag ttaggagaaa ggcactttca actttggctg aatcgccaat tttagtttcc     1980

gaaaaattgc ccttcagaaa ttatgattat gatcgcgttt ttggagcttg ctgtgaaaat     2040

gtcatcggct atatgccaat accagttggt gtaattggtc cattaattat tgatggaaca     2100

tcttatcaca taccaatggc aaccacggaa ggttgtttag tggcttcagc tatgcgtggt     2160

tgcaaagcca tcaatgctgg tggtggtgca acaactgttt taaccaaaga tggtatgact     2220

agaggcccag tcgttcgttt ccctacttta ataagatctg gtgcctgcaa gatatggtta     2280

gactcggaag agggacaaaa ttcaattaaa aaagctttta attctacatc aaggtttgca     2340

cgtttgcaac atattcaaac ctgtctagca ggcgatttgc tttttatgag atttcggaca     2400

actaccggtg acgcaatggg tatgaacatg atatcgaaag gtgtcgaata ctctttgaaa     2460

caaatggtag aagaatatgg ttgggaagat atggaagttg tctccgtatc tggtaactat     2520

tgtactgata agaaacctgc cgcaatcaat tggattgaag gtcgtggtaa aagtgtcgta     2580

gctgaagcta ctattcctgg tgatgtcgta aaaagtgttt taaagagcga tgtttccgct     2640

ttagttgaat taaatatatc caagaacttg gttggatccg caatggctgg atctgttggt     2700

ggtttcaacg cgcacgcagc taatttggtc actgcacttt tcttggcatt aggccaagat     2760

cctgcgcaga acgtcgaaag ttccaactgt ataactttga tgaaggaagt tgatggtgat     2820

ttaaggatct ctgtttccat gccatctatt gaagttggta cgattggcgg gggtactgtt     2880

ctggagcctc agggcgccat gcttgatctt ctcggcgttc gtggtcctca ccccactgaa     2940

cctggagcaa atgctaggca attagctaga ataatcgcgt gtgctgtctt ggctggtgaa     3000

ctgtctctgt gctccgcact tgctgccggt cacctggtac aaagccatat gactcacaac     3060

cgtaaaacaa acaaagccaa tgaactgcca caaccaagta acaaagggcc cccctgtaaa     3120

acctcagcat tattataa                                                   3138


<210>  35
<211>  3138
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  35
atgtcacttc ccttaaaaac gatagtacat ttggtaaagc cctttgcttg cactgctagg       60

tttagtgcga gatacccaat ccacgtcatt gttgttgctg ttttattgag tgccgctgct      120

tatctatccg tgacacaatc ttaccttaac gaatggaagc tggactctaa tcagtattct      180

acatacttaa gcataaagcc ggatgagttg tttgaaaaat gcacacacta ctataggtct      240

cctgtgtctg atacatggaa gttactcagc tctaaagaag ccgccgatat ttatacccct      300

tttcattatt atttgtctac cataagtttt caaagtaagg acaattcaac gactttgcct      360

tcccttgatg acgttattta cagtgttgac cataccaggt acttattaag tgaagagcca      420

aagataccaa ctgaactagt gtctgaaaac ggaacgaaat ggagattgag aaacaacagc      480

aattttattt tggacctgca taatatttac cgaaatatgg tgaagcaatt ttctaacaaa      540

acgagcgaat ttgatcagtt cgatttgttt atcatcctag ctgcttacct tactcttttt      600

tatactctct gttgcctgtt taatgacatg aggaaaatcg gatcaaagtt ttggttaagc      660

ttttctgctc tttcaaactc tgcatgcgca ttatatttat cgctgtacac aactcacagt      720

ttattgaaga aaccggcttc cttattaagt ttggtcattg gactaccatt tatcgtagta      780

attattggct ttaagcataa agttcgactt gcggcattct cgctacaaaa attccacaga      840

attagtattg acaagaaaat aacggtaagc aacattattt atgaggctat gtttcaagaa      900

ggtgcctact taatccgcga ctacttattt tatattagct ccttcattgg atgtgctatt      960

tatgctagac atcttcccgg attggtcaat ttctgtattt tgtctacatt tatgctagtt     1020

ttcgacttgc ttttgtctgc tactttttat tctgccattt tatcaatgaa gctggaaatt     1080

aacatcattc acagatcaac cgtcatcaga cagactttgg aagaggacgg agttgtccca     1140

actacagcag atattatata taaggatgaa actgcctcag aaccacattt tttgagatct     1200

aacgtggcta tcattctggg aaaagcatca gttattggtc ttttgcttct gatcaacctt     1260

tatgttttca cagataagtt aaatgctaca atactaaaca cggtatattt tgactctaca     1320

atttactcgt taccaaattt tatcaattat aaagatattg gcaatctcag caatcaagtg     1380

atcatttccg tgttgccaaa gcaatattat actccgctga aaaaatacca tcagatcgaa     1440

gattctgttc tacttatcat tgattccgtt agcaatgcta ttcgggacca atttatcagc     1500

aagttacttt tttttgcatt tgcagttagt atttccatca atgtctactt actgaatgct     1560

gcaaaaattc acacaggata catgaacttc caaccacaat caaataagat cgatgatctt     1620

gttgttcagc aaaaatcggc aacgattgag ttttcagaaa ctcgaagtat gcctgcttct     1680

tctggcctag aaactccagt gaccgcgaaa gatataatta tctctgaaga aatccagaat     1740

aacgaatgcg tctatgcttt gagttcccag gacgagccta tccgtccttt atcgaattta     1800

gtggaactta tggagaaaga acaattaaag aacatgaata atactgaggt ttcgaatctt     1860

gtcgtcaacg gtaaactgcc attatattcc ttagagaaaa aattagagga cacaactcgt     1920

gcggttttag ttaggagaaa ggcactttca actttggctg aatcgccaat tttagtttcc     1980

gaaaaattgc ccttcagaaa ttatgattat gatcgcgttt ttggagcttg ctgtgaaaat     2040

gtcatcggct atatgccaat accagttggt gtaattggtc cattaattat tgatggaaca     2100

tcttatcaca taccaatggc aaccacggaa ggttgtttag tggcttcagc tatgcgtggt     2160

tgcaaagcca tcaatgctgg tggtggtgca acaactgttt taaccaaaga tggtatgact     2220

agaggcccag tcgttcgttt ccctacttta ataagatctg gtgcctgcaa gatatggtta     2280

gactcggaag agggacaaaa ttcaattaaa aaagctttta attctacatc aaggtttgca     2340

cgtttgcaac atattcaaac ctgtctagca ggcgatttgc tttttatgag atttcggaca     2400

actaccggtg acgcaatggg tatgaacatg atatcgaaag gtgtcgaata ctctttgaaa     2460

caaatggtag aagaatatgg ttgggaagat atggaagttg tctccgtatc tggtaactat     2520

tgtactgata agaaacctgc cgcaatcaat tggattgaag gtcgtggtaa aagtgtcgta     2580

gctgaagcta ctattcctgg tgatgtcgta aaaagtgttt taaagagcga tgtttccgct     2640

ttagttgaat taaatatatc caagaacttg gttggatccg caatggctgg atctgttggt     2700

ggtttcaacg cgcacgcagc taatttggtc actgcacttt tcttggcatt aggccaagat     2760

cctgcgcaga acgtcgaaag ttccaactgt ataactttga tgaaggaagt tgatggtgat     2820

ttaaggatct ctgtttccat gccatctatt gaagttggta cgattggcgg gggtactgtt     2880

ctggagcctc agggcgccat gcttgatctt ctcggcgttc gtggtcctca ccccactgaa     2940

cctggagcaa atgctaggca attagctaga ataatcgcgt gtgctgtctt ggctggtgaa     3000

ctgtctctgt gctccgcact tgctgccggt cacctggtac aaagccatat gactcacaac     3060

cgtaaaacaa acaaagccaa tgaactgcca caaccaagta acaaagggcc cccctgtaaa     3120

acctcagcat tattataa                                                   3138


<210>  36
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
atctcgagtt accatacatc acggagatat ctt                                    33


<210>  37
<211>  795
<212>  DNA
<213>  Enterococcus faecalis

<400>  37
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac      540

ggcgatgatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  38
<211>  264
<212>  PRT
<213>  Enterococcus faecalis

<400>  38

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  39
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Octopine synthase gene (ocs) promoter

<400>  39
ctgaaagcga cgttggatgt taacatctac aaattgcctt ttcttatcga ccatgtacgt       60

aagcgcttac gtttttggtg gacccttgag gaaactggta gctgttgtgg gcctgtggtc      120

tcaagatgga tcattaattt ccaccttcac ctacgatggg gggcatcgca ccggtgagta      180

atattgtacg gctaagagcg aatttggcct gtaagatcct ttttaccgac aactcatcca      240

cattgatggt aggcagaaag ttaaaggatt atcgcaagtc aatacttgcc cattcattga      300

tctatttaaa ggtgtggcct caaggataat cgccaaacca ttatatttgc aatctaccaa      360


<210>  40
<211>  285
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nopalin synthase (nos) promoter

<400>  40
gatcatgagc ggagaattaa gggagtcacg ttatgacccc cgccgatgac gcgggacaag       60

ccgttttacg tttggaactg acagaaccgc aacgttgaag gagccactca gccgcgggtt      120

tctggagttt aatgagctaa gcacatacgt cagaaaccat tattgcgcgt tcaaaagtcg      180

cctaaggtca ctatcagcta gcaaatattt cttgtcaaaa atgctccact gacgttccat      240

aaattcccct cggtatccaa ttagagtctc atattcactc tcaat                      285


<210>  41
<211>  1003
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rubisco promoter (rbc)

<400>  41
cttagacaaa caccccttgt tatacaaaga atttcgcttt acaaaatcaa attcgagaaa       60

ataatatatg cactaaataa gatcattcgg atctaatcta accaattacg atacgctttg      120

ggtacacttg atttttgttt cagtggttac atatatcttg ttttatatgc tatctttaag      180

gatctgcaca aagattattt gttgatgttc ttgatggggc tcagaagatt tgatatgata      240

cactctaatc tttaggagat accagccagg attatattca gtaagacaat caaattttac      300

gtgttcaaac tcgttatctt ttcattcaaa ggatgagcca gaatctttat agaatgattg      360

caatcgagaa tatgttcggc cgatatgcct ttgttggctt caatattcta catatcacac      420

aagaatcgac cgtattgtac cctctttcca taaaggaaaa cacaatatgc agatgctttt      480

ttcccacatg cagtaacata taggtattca aaaatggcta aaagaagttg gataacaaat      540

tgacaactat ttccatttct gttatataaa tttcacaaca cacaaaagcc cgtaatcaag      600

agtctgccca tgtacgaaat aacttctatt atttggtatt gggcctaagc ccagctcaga      660

gtacgtgggg gtaccacata taggaaggta acaaaatact gcaagatagc cccataacgt      720

accagcctct ccttaccacg aagagataag atataagacc caccctgcca cgtgtcacat      780

cgtcatggtg gttaatgata agggattaca tccttctatg tttgtggaca tgatgcatgt      840

aatgtcatga gccacaagat ccaatggcca caggaacgta agaatgtaga tagatttgat      900

tttgtccgtt agatagcaaa caacattata aaaggtgtgt atcaatagga actaattcac      960

tcattggatt catagaagtc cattcctcct aagtatctag aaa                       1003


<210>  42
<211>  886
<212>  DNA
<213>  Artificial sequence

<220>
<223>  35S CaMV promoter

<400>  42
caacatgtgg agcacgacac acttgtctac tccaaaaata tcaaagatac agtctcagaa       60

gaccaaaggg caattgagac ttttcaacaa agggtaatat ccggaaacct cctcggattc      120

cattgcccag ctatctgtca ctttattgtg aagatagtgg aaaaggaagg tggctcctac      180

aaatgccatc attgcgataa aggaaaggcc atcgttgaag atgcctctgc cgacagtggt      240

cccaaagatg gacccccacc cacgaggagc atcgtggaaa aagaagacgt tccaaccacg      300

tcttcaaagc aagtggattg atgtgataac atggtggagc acgacacact tgtctactcc      360

aaaaatatca aagatacagt ctcagaagac caaagggcaa ttgagacttt tcaacaaagg      420

gtaatatccg gaaacctcct cggattccat tgcccagcta tctgtcactt tattgtgaag      480

atagtggaaa aggaaggtgg ctcctacaaa tgccatcatt gcgataaagg aaaggccatc      540

gttgaagatg cctctgccga cagtggtccc aaagatggac ccccacccac gaggagcatc      600

gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag tggattgatg tgatatctcc      660

actgacgtaa gggatgacgc acaatcccac tatccttcgc aagacccttc ctctatataa      720

ggaagttcat ttcatttgga gaggacgtcg agagttctca acacaacata tacaaaacaa      780

acgaatctca agcaatcaag cattctactt ctattgcagc aatttaaatc atttctttta      840

aagcaaaagc aattttctga aaattttcac catttacgaa cgatag                     886


<210>  43
<211>  913
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hsp18.1 heat shock inducible promoter (HS)

<400>  43
aagcttgctg cagctttgac gacaagtagg tttgttcaat tagtagcatc tttacaatgt       60

aaagcttttc tcttcatttc tctttctttc tttctttcat gcaagttcta ttgattagaa      120

accaaaacca tgacatatca cattttcaat ttttaacccc aagtttccca aaaaggtaat      180

cacaattact ttccatggtc atttcttctg gttcaagcat gacatgaaca ggcaataaat      240

aagttgagat tttgatcaca gtaactgata cttgaatcga atcatttaga tttttttttt      300

ttttagttta cttgtttagt aaatatgttg tctatgtttg tcacaaaaac gtggctcagt      360

tcttgtatat atggagacaa aaaaatccat taaaagattg ttgacattct cggaaattta      420

gtgccaactg ttattgcgag aacttactat agttttcctt tggcgaaaag ctaataatct      480

taaatcttga ttttgtcctc ttttctctga gttagatttt cttaaattcc acttccgacc      540

tattaagaaa tgggcttttg caaagaagat ccgcttcact gagcccgtat ctcgaagagg      600

ataatacaac aacaaagcaa aacggcacgt agttttaatt gtaaccaagg attgcatttc      660

ggtcttgttt caacaaacga aacttcctga aatgccaaga aaaatctggt catttcacca      720

cagtgatcat tgtgtatgtg ttctaaagac tccaagcgaa ggttttagaa aaaggagcat      780

tttctattct attcaagaaa ctcgaagaac attctctctt catcctctaa cttccctata      840

aatatgtcct ttgctaatca gatcaaatca gcaggaaaat caagaaccaa aagtctcccg      900

aaaagcaacg aca                                                         913


<210>  44
<211>  1406
<212>  DNA
<213>  Artificial sequence

<220>
<223>  super promoter (sup)

<400>  44
accggggcgt tggccgattc attaatgcag ctggacatca tgttggatat gaaacaacta       60

ttatttatct acatgtttta gatgttatct gattattttt atacgtagtc ttctattgat      120

gaggagtcta aggctataga attatatatc taaatgatta atatatatat tattaataat      180

taacaataat taatatatta taatttatat atatatattt tatattatta taataatatt      240

cttacaaata taattattat attcgacggt atcgcgataa gctcgcggat ccctgaaagc      300

gacgttggat gttaacatct acaaattgcc ttttcttatc gaccatgtac gtaagcgctt      360

acgtttttgg tggacccttg aggaaactgg tagctgttgt gggcctgtgg tctcaagatg      420

gatcattaat ttccaccttc acctacgatg gggggcatcg caccggtgag taatattgta      480

cggctaagag cgaatttggc ctgtaggatc cctgaaagcg acgttggatg ttaacatcta      540

caaattgcct tttcttatcg accatgtacg taagcgctta cgtttttggt ggacccttga      600

ggaaactggt agctgttgtg ggcctgtggt ctcaagatgg atcattaatt tccaccttca      660

cctacgatgg ggggcatcgc accggtgagt aatattgtac ggctaagagc gaatttggcc      720

tgtaggatcc ctgaaagcga cgttggatgt taacatctac aaattgcctt ttcttatcga      780

ccatgtacgt aagcgcttac gtttttggtg gacccttgag gaaactggta gctgttgtgg      840

gcctgtggtc tcaagatgga tcattaattt ccaccttcac ctacgatggg gggcatcgca      900

ccggtgagta atattgtacg gctaagagcg aatttggcct gtaggatccg cgagctggtc      960

aatcccattg cttttgaagc agctcaacat tgatctcttt ctcgatcgag ggagattttt     1020

caaatcagtg cgcaagacgt gacgtaagta tccgagtcag tttttatttt tctactaatt     1080

tggtcgttta tttcggcgtg taggacatgg caaccgggcc tgaatttcgc gggtattctg     1140

tttctattcc aactttttct tgatccgcag ccattaacga cttttgaata gatacgctga     1200

cacgccaagc ctcgctagtc aaaagtgtac caaacaacgc tttacagcaa gaacggaatg     1260

cgcgtgacgc tcgcggtgac gccatttcgc cttttcagaa atggataaat agccttgctt     1320

cctattatat cttcccccaa attaccaata cattacacta gcatctgaat ttcataacca     1380

atctcgatac accaaatcga ctctag                                          1406


<210>  45
<211>  726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ocsT (OCS terminator)

<400>  45
actagtccct agagtcctgc tttaatgaga tatgcgagac gcctatgatc gcatgatatt       60

tgctttcaat tctgttgtgc acgttgtaaa aaacctgagc atgtgtagct cagatcctta      120

ccgccggttt cggttcattc taatgaatat atcacccgtt actatcgtat ttttatgaat      180

aatattctcc gttcaattta ctgattgtac cctactactt atatgtacaa tattaaaatg      240

aaaacaatat attgtgctga ataggtttat agcgacatct atgatagagc gccacaataa      300

caaacaattg cgttttatta ttacaaatcc aattttaaaa aaagcggcag aaccggtcaa      360

acctaaaaga ctgattacat aaatcttatt caaatttcaa aagtgcccca ggggctagta      420

tctacgacac accgagcggc gaactaataa cgctcactga agggaactcc ggttccccgc      480

cggcgcgcat gggtgagatt ccttgaagtt gagtattggc cgtccgctct accgaaagtt      540

acgggcacca ttcaacccgg tccagcacgg cggccgggta accgacttgc tgccccgaga      600

attatgcagc atttttttgg tgtatgtggg ccccaaatga agtgcaggtc aaaccttgac      660

agtgacgaca aatcgttggg cgggtccagg gcgaattttg cgacaacatg tcgaggctca      720

gcagga                                                                 726


<210>  46
<211>  260
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nosT (nos terminator)

<400>  46
tcccgatcgt tcaaacattt ggcaataaag tttcttaaga ttgaatcctg ttgccggtct       60

tgcgatgatt atcatataat ttctgttgaa ttacgttaag catgtaataa ttaacatgta      120

atgcatgacg ttatttatga gatgggtttt tatgattaga gtcccgcaat tatacattta      180

atacgcgata gaaaacaaaa tatagcgcgc aaactaggat aaattatcgc gcgcggtgtc      240

atctatgtta ctagatcggg                                                  260


<210>  47
<211>  918
<212>  DNA
<213>  Artificial sequence

<220>
<223>  rbcT (rbc terminator)

<400>  47
tcataagccc gatggctact aagttttact atttaccaag acttttgaat attaaccttc       60

ttgtaacgag tcggttaaat ttgattgttt agggttttgt attatttttt tttggtcttt      120

taattcatca ctttaattcc ctaattgtct gttcatttcg ttgtttgttt ccggatcgat      180

aatgaaatgt aagagatatc atatataaat aataaattgt cgtttcatat ttgcaatctt      240

ttttttacaa acctttaatc gttgtatgta tgacattttc ttcttgttat attaggggga      300

aataatgtta aataaaagta caaaataaac tacagtacat cgtactgaat aaattaccta      360

gccaaaaagt acacctttcc atatacttcc tacatgaagg cattttcaac attttcaaat      420

aaggaatgct acaaccgcat aataacatcc acaaattttt ttataaaata acatgtcaga      480

cagtgattga aagattttat tatagtttcg ttatcttctt ttctcattaa gcgaatcact      540

acctaacacg tcattttgtg aaatattttt tgaatgtttt tatatagttg tagcattcct      600

cttttcaaat tagggtttgt ttgagatagc atttcagccg gttcatacaa cttaaaagca      660

tactctaatg ctggaaaaaa gactaaaaaa tcttgtaagt tagcgcagaa tattgaccca      720

aattatatac acacatgacc ccatatagag actaattaca cttttaacca ctaataatta      780

ttactgtatt ataacatcta ctaattaaac ttgtgagttt ttgctagaat tattatcata      840

tatactaaaa ggcaggaacg caaacattgc cccggtactg tagcaactac ggtagacgca      900

ttaattgtct atagtgga                                                    918


<210>  48
<211>  211
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CaMV 35S terminator

<400>  48
gtccgcaaaa atcaccagtc tctctctaca aatctatctc tctctatttt tctccagaat       60

aatgtgtgag tagttcccag ataagggaat tagggttctt atagggtttc gctcatgtgt      120

tgagcatata agaaaccctt agtatgtatt tgtatttgta aaatacttct atcaataaaa      180

tttctaattc ctaaaaccaa aatccagtga c                                     211


<210>  49
<211>  406
<212>  DNA
<213>  Artificial sequence

<220>
<223>  agsT (ags terminator)

<400>  49
gaattaacag aggtggatgg acagacccgt tcttacaccg gactgggcgc gggataggat       60

attcagattg ggatgggatt gagcttaaag ccggcgctga gaccatgctc aaggtaggca      120

atgtcctcag cgtcgagccc ggcatctatg tcgagggcat tggtggagcg cgcttcgggg      180

ataccgtgct tgtaactgag accggatatg aggccctcac tccgcttgat cttggcaaag      240

atatttgacg catttattag tatgtgttaa ttttcatttg cagtgcagta ttttctattc      300

gatctttatg taattcgtta caattaataa atattcaaat cagattattg actgtcattt      360

gtatcaaatc gtgtttaatg gatattttta ttataatatt gatgat                     406


<210>  50
<211>  1641
<212>  DNA
<213>  Artemisia annua

<400>  50
atgtcactta cagaagaaaa acctattcgc cccattgcca actttcctcc aagcatttgg       60

ggagatcagt ttctcatcta tgaaaagcaa gtagagcaag gggtggaaca gatagtgaat      120

gatttaaaaa aagaagtgcg gcaactacta aaagaagctt tggatattcc tatgaaacat      180

gccaatttgt tgaagctgat tgatgaaatc caacgccttg gaataccgta tcactttgaa      240

cgggagattg atcatgcatt gcaatgtatt tatgaaacat atggtgataa ctggaatggt      300

gaccgctctt ccttatggtt ccgtcttatg cgaaagcaag gatattatgt tacatgtgat      360

gttttcaata actataaaga caaaaatgga gcgttcaagc aatcgttagc taatgatgtt      420

gaaggtttgc ttgagttgta cgaagcaact tctatgaggg tacctgggga gattatatta      480

gaagatgctc ttggttttac acgatctcgt cttagcatta tgacaaaaga tgctttttct      540

acaaaccccg ctctttttac cgaaatacaa cgggcactaa agcaacccct ttggaaaagg      600

ttgccaagaa tagaggcggc gcagtacatt cctttctatc aacaacaaga ttctcataac      660

aagactttac ttaaacttgc taagttagag ttcaatttgc ttcagtcatt gcacaaggaa      720

gagctcagcc atgtgtgcaa atggtggaaa gctttcgata tcaagaagaa cgcaccttgt      780

ttaagagata gaattgttga atgctacttt tggggactag gttcaggcta tgagccacag      840

tattcccggg ctagagtttt cttcacaaaa gctgttgctg ttataactct tatagatgac      900

acttatgatg cgtatggtac ttatgaagaa cttaagatct ttactgaagc tgttgaaagg      960

tggtcaatta catgcttaga cacacttcca gaatacatga aaccgatata caaattattc     1020

atggatacat acacagaaat ggaagaattt cttgcaaagg agggaagaac agatctattt     1080

aactgcggca aagaatttgt gaaagagttt gttagaaacc tgatgtttga agcaaaatgg     1140

gcaaatgagg gacacatacc aaccactgaa gagcatgatc cagttgtaat cattactggc     1200

ggtgctaacc tgcttacaac aacttgttat cttggcatga gtgatatatt cacaaaagag     1260

tctgtcgaat gggctgtctc tgcacctcct ctttttagat actcaggtat acttggtcga     1320

cgcctaaatg atctcatgac ccacaaggcc gagcaagaaa gaaaacatag ttcatcgagc     1380

cttgaaagtt atatgaagga atataatgtc aatgaggagt atgcccaaac cttgatttac     1440

aaggaagtag aagatgtgtg gaaagatata aaccgagagt acctcacaac taaaaacatt     1500

ccaaggccgt tattgatggc tgtgatctat ttgtgccagt ttcttgaagt tcaatatgca     1560

ggaaaggata acttcacacg tatgggagac gaatacaaac atctcataaa gtctctactc     1620

gtttatccta tgagtatatg a                                               1641


<210>  51
<211>  546
<212>  PRT
<213>  Artemisia annua

<400>  51

Met Ser Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro 
1               5                   10                  15      


Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu 
            20                  25                  30          


Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln 
        35                  40                  45              


Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu 
    50                  55                  60                  


Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu 
65                  70                  75                  80  


Arg Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp 
                85                  90                  95      


Asn Trp Asn Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys 
            100                 105                 110         


Gln Gly Tyr Tyr Val Thr Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys 
        115                 120                 125             


Asn Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Ile Leu 
145                 150                 155                 160 


Glu Asp Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ile Met Thr Lys 
                165                 170                 175     


Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala 
            180                 185                 190         


Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln 
        195                 200                 205             


Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu 
    210                 215                 220                 


Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu 
225                 230                 235                 240 


Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys 
                245                 250                 255     


Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly 
            260                 265                 270         


Leu Gly Ser Gly Tyr Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe 
        275                 280                 285             


Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg 
305                 310                 315                 320 


Trp Ser Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile 
                325                 330                 335     


Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala 
            340                 345                 350         


Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Gly Lys Glu Phe Val Lys 
        355                 360                 365             


Glu Phe Val Arg Asn Leu Met Phe Glu Ala Lys Trp Ala Asn Glu Gly 
    370                 375                 380                 


His Ile Pro Thr Thr Glu Glu His Asp Pro Val Val Ile Ile Thr Gly 
385                 390                 395                 400 


Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile 
                405                 410                 415     


Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe 
            420                 425                 430         


Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His 
        435                 440                 445             


Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr 
    450                 455                 460                 


Met Lys Glu Tyr Asn Val Asn Glu Glu Tyr Ala Gln Thr Leu Ile Tyr 
465                 470                 475                 480 


Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr 
                485                 490                 495     


Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys 
            500                 505                 510         


Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met 
        515                 520                 525             


Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met 
    530                 535                 540                 


Ser Ile 
545     


<210>  52
<211>  1650
<212>  DNA
<213>  Artemisia annua

<400>  52
ttgaaaatca tgtcacttac agaagaaaaa cctattcgcc ccattgccaa ctttcctcca       60

agcatttggg gagatcagtt tctcatctat gaaaagcaag tagagcaagg ggtggaacag      120

atagtgaatg atttaaaaaa agaagtgcgg caactactaa aagaagcttt ggatattcct      180

atgaaacatg ccaatttgtt gaagctgatt gatgaaatcc aacgccttgg aataccgtat      240

cactttgaac gggagattga tcatgcattg caatgtattt atgaaacata tggtgataac      300

tggaatggtg accgctcttc cttatggttc cgtcttatgc gaaagcaagg atattatgtt      360

acatgtgatg ttttcaataa ctataaagac aaaaatggag cgttcaagca atcgttagct      420

aatgatgttg aaggtttgct tgagttgtac gaagcaactt ctatgagggt acctggggag      480

attatattag aagatgctct tggttttaca cgatctcgtc ttagcattat gacaaaagat      540

gctttttcta caaaccccgc tctttttacc gaaatacaac gggcactaaa gcaacccctt      600

tggaaaaggt tgccaagaat agaggcggcg cagtacattc ctttctatca acaacaagat      660

tctcataaca agactttact taaacttgct aagttagagt tcaatttgct tcagtcattg      720

cacaaggaag agctcagcca tgtgtgcaaa tggtggaaag ctttcgatat caagaagaac      780

gcaccttgtt taagagatag aattgttgaa tgctactttt ggggactagg ttcaggctat      840

gagccacagt attcccgggc tagagttttc ttcacaaaag ctgttgctgt tataactctt      900

atagatgaca cttatgatgc gtatggtact tatgaagaac ttaagatctt tactgaagct      960

gttgaaaggt ggtcaattac atgcttagac acacttccag aatacatgaa accgatatac     1020

aaattattca tggatacata cacagaaatg gaagaatttc ttgcaaagga gggaagaaca     1080

gatctattta actgcggcaa agaatttgtg aaagagtttg ttagaaacct gatgtttgaa     1140

gcaaaatggg caaatgaggg acacatacca accactgaag agcatgatcc agttgtaatc     1200

attactggcg gtgctaacct gcttacaaca acttgttatc ttggcatgag tgatatattc     1260

acaaaagagt ctgtcgaatg ggctgtctct gcacctcctc tttttagata ctcaggtata     1320

cttggtcgac gcctaaatga tctcatgacc cacaaggccg agcaagaaag aaaacatagt     1380

tcatcgagcc ttgaaagtta tatgaaggaa tataatgtca atgaggagta tgcccaaacc     1440

ttgatttaca aggaagtaga agatgtgtgg aaagatataa accgagagta cctcacaact     1500

aaaaacattc caaggccgtt attgatggct gtgatctatt tgtgccagtt tcttgaagtt     1560

caatatgcag gaaaggataa cttcacacgt atgggagacg aatacaaaca tctcataaag     1620

tctctactcg tttatcctat gagtatataa                                      1650


<210>  53
<211>  162
<212>  DNA
<213>  Nicotiana plumbaginifolia

<400>  53
atggcttctc ggaggcttct cacctctctc ctccgtcaat cggctcaacg tggcggcggt       60

ccaatttccc gatccttggg aaactccatc cctaaatccg ctgcacgcgc ctcttcacgc      120

gcgtccccta agggattcct cttaaaccgc gccgtacagt ac                         162


<210>  54
<211>  54
<212>  PRT
<213>  Nicotiana plumbaginifolia

<400>  54

Met Ala Ser Arg Arg Leu Leu Thr Ser Leu Leu Arg Gln Ser Ala Gln 
1               5                   10                  15      


Arg Gly Gly Gly Pro Ile Ser Arg Ser Leu Gly Asn Ser Ile Pro Lys 
            20                  25                  30          


Ser Ala Ala Arg Ala Ser Ser Arg Ala Ser Pro Lys Gly Phe Leu Leu 
        35                  40                  45              


Asn Arg Ala Val Gln Tyr 
    50                  


<210>  55
<211>  99
<212>  DNA
<213>  Arabidopsis thaliana

<400>  55
atggatatgc agaatgaaaa cgagagattg atggtcttcg aacatgctcg caaagtagca       60

gaagcaacct acgtcaaaaa ccctttagat gccgagaat                              99


<210>  56
<211>  33
<212>  PRT
<213>  Arabidopsis thaliana

<400>  56

Met Asp Met Gln Asn Glu Asn Glu Arg Leu Met Val Phe Glu His Ala 
1               5                   10                  15      


Arg Lys Val Ala Glu Ala Thr Tyr Val Lys Asn Pro Leu Asp Ala Glu 
            20                  25                  30          


Asn 
    


<210>  57
<211>  198
<212>  DNA
<213>  Arabidopsis thaliana

<400>  57
atggtgtggt ttcgtgctgg ttccagtgtt acaaagctag ctgttagaag gattttgaat       60

cagggtgctt cgtatgcgac gaggacacgg tctattccgt ctcaaactcg ttcctttcac      120

tcgactatat gcagaccaaa ggctcagagt gctccagttc ctagagctgt tcctctttct      180

aagctaactg atagtttc                                                    198


<210>  58
<211>  66
<212>  PRT
<213>  Arabidopsis thaliana

<400>  58

Met Val Trp Phe Arg Ala Gly Ser Ser Val Thr Lys Leu Ala Val Arg 
1               5                   10                  15      


Arg Ile Leu Asn Gln Gly Ala Ser Tyr Ala Thr Arg Thr Arg Ser Ile 
            20                  25                  30          


Pro Ser Gln Thr Arg Ser Phe His Ser Thr Ile Cys Arg Pro Lys Ala 
        35                  40                  45              


Gln Ser Ala Pro Val Pro Arg Ala Val Pro Leu Ser Lys Leu Thr Asp 
    50                  55                  60                  


Ser Phe 
65      


<210>  59
<211>  87
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  59
atgctttcac tacgtcaatc tataagattt ttcaagccag ccacaagaac tttgtgtagc       60

tctagatatc tgcttcagca aaaaccc                                           87


<210>  60
<211>  29
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  60

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu Gln Gln Lys Pro 
            20                  25                  


<210>  61
<211>  1374
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  61

Met Lys Val Ser Asp Arg Arg Lys Phe Glu Lys Ala Asn Phe Asp Glu 
1               5                   10                  15      


Phe Glu Ser Ala Leu Asn Asn Lys Asn Asp Leu Val His Cys Pro Ser 
            20                  25                  30          


Ile Thr Leu Phe Glu Ser Ile Pro Thr Glu Val Arg Ser Phe Tyr Glu 
        35                  40                  45              


Asp Glu Lys Ser Gly Leu Ile Lys Val Val Lys Phe Arg Thr Gly Ala 
    50                  55                  60                  


Met Asp Arg Lys Arg Ser Phe Glu Lys Ile Val Val Ser Val Met Val 
65                  70                  75                  80  


Gly Lys Asn Val Gln Lys Phe Leu Thr Phe Val Glu Asp Glu Pro Asp 
                85                  90                  95      


Phe Gln Gly Gly Pro Ile Pro Ser Lys Tyr Leu Ile Pro Lys Lys Ile 
            100                 105                 110         


Asn Leu Met Val Tyr Thr Leu Phe Gln Val His Thr Leu Lys Phe Asn 
        115                 120                 125             


Arg Lys Asp Tyr Asp Thr Leu Ser Leu Phe Tyr Leu Asn Arg Gly Tyr 
    130                 135                 140                 


Tyr Asn Glu Leu Ser Phe Arg Val Leu Glu Arg Cys His Glu Ile Ala 
145                 150                 155                 160 


Ser Ala Arg Pro Asn Asp Ser Ser Thr Met Arg Thr Phe Thr Asp Phe 
                165                 170                 175     


Val Ser Gly Ala Pro Ile Val Arg Ser Leu Gln Lys Ser Thr Ile Arg 
            180                 185                 190         


Arg Tyr Gly Tyr Asn Leu Ala Pro His Met Phe Leu Leu Leu His Val 
        195                 200                 205             


Asp Glu Leu Ser Ile Phe Ser Ala Tyr Gln Ala Ser Leu Pro Gly Glu 
    210                 215                 220                 


Lys Lys Val Asp Thr Glu Arg Leu Lys Arg Asp Leu Cys Pro Arg Lys 
225                 230                 235                 240 


Pro Ile Glu Ile Lys Tyr Phe Ser Gln Ile Cys Asn Asp Met Met Asn 
                245                 250                 255     


Lys Lys Asp Arg Leu Gly Asp Val Leu Ala Thr Ala Gln Arg Ile Arg 
            260                 265                 270         


Arg Arg Tyr Asn Lys Asn Ser Ser Ser Glu Pro Arg Leu Lys Thr Leu 
        275                 280                 285             


Asp Gly Leu Thr Ser Glu Arg Trp Ile Gln Trp Leu Gly Leu Glu Ser 
    290                 295                 300                 


Asp Tyr His Cys Ser Phe Ser Ser Thr Arg Asn Ala Glu Asp Val Val 
305                 310                 315                 320 


Ala Gly Glu Ala Ala Ser Ser Asp His His Gln Lys Ile Ser Arg Val 
                325                 330                 335     


Thr Arg Lys Arg Pro Arg Glu Pro Lys Ser Thr Asn Asp Ile Leu Val 
            340                 345                 350         


Ala Gly Gln Lys Leu Phe Gly Ser Ser Phe Glu Phe Arg Asp Leu His 
        355                 360                 365             


Gln Leu Arg Leu Cys His Glu Ile Tyr Met Ala Asp Thr Pro Ser Val 
    370                 375                 380                 


Ala Val Gln Ala Pro Pro Gly Tyr Gly Lys Thr Glu Leu Phe His Leu 
385                 390                 395                 400 


Pro Leu Ile Ala Leu Ala Ser Lys Gly Asp Val Lys Tyr Val Ser Phe 
                405                 410                 415     


Leu Phe Val Pro Tyr Thr Val Leu Leu Ala Asn Cys Met Ile Arg Leu 
            420                 425                 430         


Ser Arg Cys Gly Cys Leu Asn Val Ala Pro Val Arg Asn Phe Ile Glu 
        435                 440                 445             


Glu Gly Cys Asp Gly Val Thr Asp Leu Tyr Val Gly Ile Tyr Asp Asp 
    450                 455                 460                 


Leu Ala Ser Thr Asn Phe Thr Asp Arg Ile Ala Ala Trp Glu Asn Ile 
465                 470                 475                 480 


Val Glu Cys Thr Phe Arg Thr Asn Asn Val Lys Leu Gly Tyr Leu Ile 
                485                 490                 495     


Val Asp Glu Phe His Asn Phe Glu Thr Glu Val Tyr Arg Gln Ser Gln 
            500                 505                 510         


Phe Gly Gly Ile Thr Asn Leu Asp Phe Asp Ala Phe Glu Lys Ala Ile 
        515                 520                 525             


Phe Leu Ser Gly Thr Ala Pro Glu Ala Val Ala Asp Ala Ala Leu Gln 
    530                 535                 540                 


Arg Ile Gly Leu Thr Gly Leu Ala Lys Lys Ser Met Asp Ile Asn Glu 
545                 550                 555                 560 


Leu Lys Arg Ser Glu Asp Leu Ser Arg Gly Leu Ser Ser Tyr Pro Thr 
                565                 570                 575     


Arg Met Phe Asn Leu Ile Lys Glu Lys Ser Glu Val Pro Leu Gly His 
            580                 585                 590         


Val His Lys Ile Trp Lys Lys Val Glu Ser Gln Pro Glu Glu Ala Leu 
        595                 600                 605             


Lys Leu Leu Leu Ala Leu Phe Glu Ile Glu Pro Glu Ser Lys Ala Ile 
    610                 615                 620                 


Val Val Ala Ser Thr Thr Asn Glu Val Glu Glu Leu Ala Cys Ser Trp 
625                 630                 635                 640 


Arg Lys Tyr Phe Arg Val Val Trp Ile His Gly Lys Leu Gly Ala Ala 
                645                 650                 655     


Glu Lys Val Ser Arg Thr Lys Glu Phe Val Thr Asp Gly Ser Met Arg 
            660                 665                 670         


Val Leu Ile Gly Thr Lys Leu Val Thr Glu Gly Ile Asp Ile Lys Gln 
        675                 680                 685             


Leu Met Met Val Ile Met Leu Asp Asn Arg Leu Asn Ile Ile Glu Leu 
    690                 695                 700                 


Ile Gln Gly Val Gly Arg Leu Arg Asp Gly Gly Leu Cys Tyr Leu Leu 
705                 710                 715                 720 


Ser Arg Lys Asn Ser Trp Ala Ala Arg Asn Arg Lys Gly Glu Leu Pro 
                725                 730                 735     


Pro Ile Lys Glu Gly Cys Ile Thr Glu Gln Val Arg Glu Phe Tyr Gly 
            740                 745                 750         


Leu Glu Ser Lys Lys Gly Lys Lys Gly Gln His Val Gly Cys Cys Gly 
        755                 760                 765             


Ser Arg Thr Asp Leu Ser Ala Asp Thr Val Glu Leu Ile Glu Arg Met 
    770                 775                 780                 


Asp Arg Leu Ala Glu Lys Gln Ala Thr Ala Ser Met Ser Ile Val Ala 
785                 790                 795                 800 


Leu Pro Ser Ser Phe Gln Glu Ser Asn Ser Ser Asp Arg Cys Arg Lys 
                805                 810                 815     


Tyr Cys Ser Ser Asp Glu Asp Ser Asp Thr Cys Ile His Gly Ser Ala 
            820                 825                 830         


Asn Ala Ser Thr Asn Ala Thr Thr Asn Ser Ser Thr Asn Ala Thr Thr 
        835                 840                 845             


Thr Ala Ser Thr Asn Val Arg Thr Ser Ala Thr Thr Thr Ala Ser Ile 
    850                 855                 860                 


Asn Val Arg Thr Ser Ala Thr Thr Thr Glu Ser Thr Asn Ser Ser Thr 
865                 870                 875                 880 


Asn Ala Thr Thr Thr Ala Ser Thr Asn Val Arg Thr Ser Ala Thr Thr 
                885                 890                 895     


Thr Ala Ser Ile Asn Val Arg Thr Ser Ala Thr Thr Thr Glu Ser Thr 
            900                 905                 910         


Asn Ser Asn Thr Ser Ala Thr Thr Thr Glu Ser Thr Asp Ser Asn Thr 
        915                 920                 925             


Ser Ala Thr Thr Thr Glu Ser Thr Asp Ser Asn Thr Ser Ala Thr Thr 
    930                 935                 940                 


Thr Ala Ser Thr Asn Ser Ser Thr Asn Ala Thr Thr Thr Ala Ser Thr 
945                 950                 955                 960 


Asn Ser Ser Thr Asn Ala Thr Thr Thr Glu Ser Thr Asn Ala Ser Ala 
                965                 970                 975     


Lys Glu Asp Ala Asn Lys Asp Gly Asn Ala Glu Asp Asn Arg Phe His 
            980                 985                 990         


Pro Val Thr Asp Ile Asn Lys Glu  Ser Tyr Lys Arg Lys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Leu Leu Glu Arg Lys  Lys Leu Lys Ala Gln  Phe Pro Asn 
    1010                 1015                 1020             


Thr Ser  Glu Asn Met Asn Val  Leu Gln Phe Leu Gly  Phe Arg Ser 
    1025                 1030                 1035             


Asp Glu  Ile Lys His Leu Phe  Leu Tyr Gly Ile Asp  Ile Tyr Phe 
    1040                 1045                 1050             


Cys Pro  Glu Gly Val Phe Thr  Gln Tyr Gly Leu Cys  Lys Gly Cys 
    1055                 1060                 1065             


Gln Lys  Met Phe Glu Leu Cys  Val Cys Trp Ala Gly  Gln Lys Val 
    1070                 1075                 1080             


Ser Tyr  Arg Arg Met Ala Trp  Glu Ala Leu Ala Val  Glu Arg Met 
    1085                 1090                 1095             


Leu Arg  Asn Asp Glu Glu Tyr  Lys Glu Tyr Leu Glu  Asp Ile Glu 
    1100                 1105                 1110             


Pro Tyr  His Gly Asp Pro Val  Gly Tyr Leu Lys Phe  Phe Ser Val 
    1115                 1120                 1125             


Lys Arg  Gly Glu Ile Tyr Ser  Gln Ile Gln Arg Asn  Tyr Ala Trp 
    1130                 1135                 1140             


Tyr Leu  Ala Ile Thr Arg Arg  Arg Glu Thr Ile Ser  Val Leu Asp 
    1145                 1150                 1155             


Ser Thr  Arg Gly Lys Gln Gly  Ser Gln Val Phe Arg  Met Ser Gly 
    1160                 1165                 1170             


Arg Gln  Ile Lys Glu Leu Tyr  Tyr Lys Val Trp Ser  Asn Leu Arg 
    1175                 1180                 1185             


Glu Ser  Lys Thr Glu Val Leu  Gln Tyr Phe Leu Asn  Trp Asp Glu 
    1190                 1195                 1200             


Lys Lys  Cys Arg Glu Glu Trp  Glu Ala Lys Asp Asp  Thr Val Phe 
    1205                 1210                 1215             


Val Glu  Ala Leu Glu Lys Val  Gly Val Phe Gln Arg  Leu Arg Ser 
    1220                 1225                 1230             


Met Thr  Ser Ala Gly Leu Gln  Gly Pro Gln Tyr Val  Lys Leu Gln 
    1235                 1240                 1245             


Phe Ser  Arg His His Arg Gln  Leu Arg Ser Arg Tyr  Glu Leu Ser 
    1250                 1255                 1260             


Leu Gly  Met His Leu Arg Asp  Gln Leu Ala Leu Gly  Val Thr Pro 
    1265                 1270                 1275             


Ser Lys  Val Pro His Trp Thr  Ala Phe Leu Ser Met  Leu Ile Gly 
    1280                 1285                 1290             


Leu Phe  Tyr Asn Lys Thr Phe  Arg Gln Lys Leu Glu  Tyr Leu Leu 
    1295                 1300                 1305             


Glu Gln  Ile Ser Glu Val Trp  Leu Leu Pro His Trp  Val Asp Leu 
    1310                 1315                 1320             


Ala Asn  Val Glu Val Leu Ala  Ala Asp Asn Thr Arg  Val Pro Leu 
    1325                 1330                 1335             


Tyr Met  Leu Met Val Ala Val  His Lys Glu Leu Asp  Ser Asp Asp 
    1340                 1345                 1350             


Val Pro  Asp Gly Arg Phe Asp  Ile Ile Leu Leu Cys  Arg Asp Ser 
    1355                 1360                 1365             


Ser Arg  Glu Val Gly Glu 
    1370                 


<210>  62
<211>  4125
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  62
tcactctcca acttctctgc tcgaatctct acatagtaat attatatcaa atctaccgtc       60

tggaacatca tcgctatcca gctctttgtg aaccgctacc atcagcatgt acagcggtac      120

cctcgtgtta tctgcagcga gaacttcaac gtttgccaaa tcaacccaat gtggtaacaa      180

ccacacctcc gaaatctgct ccaaaagata ttccagtttc tgccgaaatg ttttattgta      240

gaacagccct atcagcatcg acaggaatgc cgtccaatgc ggcactttag atggggtaac      300

tcccagcgca agctgatctc gcaagtgcat tcctagactt aattcatatc tgctcctcaa      360

ctgtcgatga tgcctgctaa actgcagctt gacgtactgc ggaccctgca gtccagcgct      420

cgtcatggaa cgcaaacgct gaaaaactcc aactttctcg agcgcttcca caaagaccgt      480

atcgtctttt gcctcccatt cttcccggca ctttttttcg tcccagttca aaaagtactg      540

cagcacctct gtcttcgatt cacgcaagtt gctccatact ttataataca actctttgat      600

ctgccttcca gacatgcgga aaacttggct cccttgcttg cctcttgtcg aatccaatac      660

actaattgtt tctcttcttc tagtaatggc caggtaccaa gcataatttc tctgtatctg      720

agagtagatc tctccccttt ttacgctaaa aaatttcaaa taccctacag ggtccccatg      780

atatggctcg atgtcttcca agtattcttt gtattcctcg tcatttcgca gcattctctc      840

cacagctagt gcttcccaag ccatcctccg atacgatact ttctggccag cccaacagac      900

acagagctcg aacatctttt gacagccctt gcataatccg tattgtgtga atactccctc      960

tgggcagaag tatatgtcaa taccatagag gaaaagatgt ttaatttcgt cagaccgaaa     1020

tccaagaaac tgtaagacat tcatattctc ggaagtattg ggaaattgtg ctttcagttt     1080

ctttctctct agcaaaacca tttgactccc tttccgctta tacgactctt tgttaatgtc     1140

ggtgactgga tggaatctat tatcctcagc attgccatct ttattggcgt cctccttggc     1200

actagcgttg gtactttcag tggtagtggc attagtgctg gagttggtgc tagcagtggt     1260

agtggcatta gtgctggagt tggtgctagc agtggtagta gcactagtgt tggagtcggt     1320

actttcggtg gtagtagcac tagtgttgga gtcggtactt tcggtggtag tagcactagt     1380

gttggagttg gtactttcag tggtagtcgc actagtcctg acgttgatgc tggcagtggt     1440

agtagcacta gtcctgacgt tggtgctggc agtggtagta gcattagtgc tggagttggt     1500

actttcagtg gtagtcgcac tagtcctgac gttgatgctg gcagtggtag tagcactagt     1560

cctgacgttg gtgctggcag tggtagtagc attagtgctg gagttggtag tcgcattggt     1620

actggcatta gcactaccat gaatgcacgt gtcgctgtcc tcatcactgc tgcaatactt     1680

tctgcacctg tcactgctat tgctctcctg gaagctagac ggtaacgcaa cgatcgacat     1740

ggaagctgtc gcctgttttt cagccaatct gtccattctt tctatcagtt ccactgtgtc     1800

agcagacagg tctgtcctgg agccacagca tccaacatgc tggccctttt ttcctttctt     1860

tgattcaagt ccatagaact cgcgtacctg ttcggttata cagccttcct taattggtgg     1920

taattcaccc ttacgattcc ttgccgccca actgtttttt ctagataata gataacagag     1980

gcccccatct cttagtctcc ctacgccttg aatgagctca ataatattaa gtctattatc     2040

aagcatgatc accatcatca attgcttaat gtcaattcct tcagtcacta atttcgttcc     2100

gatgagaact cgcatgctac cgtcagtgac aaactccttt gtgcgagaca ccttttctgc     2160

agcacccagc ttcccgtgta tccataccac cctaaaatac tttctccaag agcaggccaa     2220

ttcttccact tcgttggttg tgcttgcaac tacaatggcc ttcgactctg gttcaatttc     2280

aaagagggct aaaagaagct tcagtgcttc ttcgggctgt gattccactt tcttccaaat     2340

tttatgaaca tgccctaaag gcacctcgga tttctccttg attagattaa acatccgtgt     2400

tggatagctg gatagacctc tgctgagatc ttccgaccgt ttgagctcgt tgatgtccat     2460

cgacttcttg gccagtcccg taagcccaat acgctgcaac gcagcatcag ctacagcctc     2520

aggtgctgtg ccgctcaaaa agattgcttt ctcaaaagcg tcaaaatcaa ggttagttat     2580

gcccccaaat tgcgactgcc ggtagacctc cgtttcaaag ttgtgaaact catctacaat     2640

gaggtaaccc aattttacgt tgttggtcct aaaggtgcac tcaacaatat tctcccacgc     2700

agctatcctg tctgtgaaat tagtgctagc aagatcatcg tagatcccca cgtataaatc     2760

agtaacgcca tcgcaacctt cttcaataaa gtttcttaca ggggccacat tcaagcaacc     2820

gcatcggctc aacctgatca tgcaattagc aagcaacact gtgtacggta caaacagaaa     2880

cgacacatat ttcacgtcgc ccttagacgc cagtgctatc aaggggagat gaaataactc     2940

cgtcttacca tagcccggtg gggcctgtac tgccacagag ggtgtgtctg ccatgtatat     3000

ttcatgacat aagcgcaact gatgcaagtc cctgaattca aaggagctgc caaagagttt     3060

ctggcctgcg acgaggatat cgtttgtact cttgggctct cggggccttt ttcgcgttac     3120

tcttgaaatt ttttgatgat gatctgaact cgccgcctca cctgccacta cgtcttccgc     3180

attccgagta ctagagaatg aacaatggta gtcgctttca aggcctaacc attgaatcca     3240

gcgctcggaa gtgagtccgt caagcgtctt tagtcgaggc tccgatgaac tgttcttgtt     3300

gtatcgtcga cgtatacgtt gcgctgtagc taaaacatca cccaatcggt cctttttgtt     3360

catcatatcg ttacatatct gtgaaaagta ctttatctca atgggtttac gtgggcatag     3420

atcacgcttc agccgctctg tgtcgacttt cttttcgcca ggtaaacttg cttggtatgc     3480

agaaaaaatc gatagctcat ctacgtgtag taacaaaaac atgtggggtg ccaaattgta     3540

cccatatctc cttatggtgc ttttctgaag actccttaca ataggtgcgc cagaaacaaa     3600

gtcagtgaaa gtacgcatcg tagagctgtc gttcggcctg gcactcgcta tttcgtgaca     3660

acgttccagg acacggaaac tcaactcatt atagtatcct ctgttgaggt aaaaaagaga     3720

aagggtatcg taatcctttc tattgaattt caaagtatgc acttgaaaca acgtgtagac     3780

catcaagttg attttcttgg gaataagata ctttgaaggg attggtccgc cctggaaatc     3840

tggttcgtct tcaacaaacg tcaggaactt ttgtacattt ttcccgacca tgacggaaac     3900

gacaattttt tcaaaagacc ttttcctatc cattgcacca gttctgaatt ttaccacttt     3960

gattaggcca gacttttcgt cttcgtagaa tgaccgcact tccgtgggga tcgattcaaa     4020

taaagttatt gagggacaat gtaccaagtc gtttttgtta tttagagccg actcaaactc     4080

gtcaaagttt gctttttcaa acttacgcct atcggaaact ttcat                     4125


<210>  63
<211>  1578
<212>  DNA
<213>  Artificial sequence

<220>
<223>  N'-terminal truncated 3-hydroxy-3-methylglutaryl-coenzyme A 
       reductase

<400>  63
atggaccaat tggtgaaaac tgaagtcacc aagaagtctt ttactgctcc tgtacaaaag       60

gcttctacac cagttttaac caataaaaca gtcatttctg gatcgaaagt caaaagttta      120

tcatctgcgc aatcgagctc atcaggacct tcatcatcta gtgaggaaga tgattcccgc      180

gatattgaaa gcttggataa gaaaatacgt cctttagaag aattagaagc attattaagt      240

agtggaaata caaaacaatt gaagaacaaa gaggtcgctg ccttggttat tcacggtaag      300

ttacctttgt acgctttgga gaaaaaatta ggtgatacta cgagagcggt tgcggtacgt      360

aggaaggctc tttcaatttt ggcagaagct cctgtattag catctgatcg tttaccatat      420

aaaaattatg actacgaccg cgtatttggc gcttgttgtg aaaatgttat aggttacatg      480

cctttgcccg ttggtgttat aggccccttg gttatcgatg gtacatctta tcatatacca      540

atggcaacta cagagggttg tttggtagct tctgccatgc gtggctgtaa ggcaatcaat      600

gctggcggtg gtgcaacaac tgttttaact aaggatggta tgacaagagg cccagtagtc      660

cgtttcccaa ctttgaaaag atctggtgcc tgtaagatat ggttagactc agaagaggga      720

caaaacgcaa ttaaaaaagc ttttaactct acatcaagat ttgcacgtct gcaacatatt      780

caaacttgtc tagcaggaga tttactcttc atgagattta gaacaactac tggtgacgca      840

atgggtatga atatgatttc taaaggtgtc gaatactcat taaagcaaat ggtagaagag      900

tatggctggg aagatatgga ggttgtctcc gtttctggta actactgtac cgacaaaaaa      960

ccagctgcca tcaactggat cgaaggtcgt ggtaagagtg tcgtcgcaga agctactatt     1020

cctggtgatg ttgtcagaaa agtgttaaaa agtgatgttt ccgcattggt tgagttgaac     1080

attgctaaga atttggttgg atctgcaatg gctgggtctg ttggtggatt taacgcacat     1140

gcagctaatt tagtgacagc tgttttcttg gcattaggac aagatcctgc acaaaatgtt     1200

gaaagttcca actgtataac attgatgaaa gaagtggacg gtgatttgag aatttccgta     1260

tccatgccat ccatcgaagt aggtaccatc ggtggtggta ctgttctaga accacaaggt     1320

gccatgttgg acttattagg tgtaagaggc ccgcatgcta ccgctcctgg taccaacgca     1380

cgtcaattag caagaatagt tgcctgtgcc gtcttggcag gtgaattatc cttatgtgct     1440

gccctagcag ccggccattt ggttcaaagt catatgaccc acaacaggaa acctgctgaa     1500

ccaacaaaac ctaacaattt ggacgccact gatataaatc gtttgaaaga tgggtccgtc     1560

acctgcatta aatcctaa                                                   1578


<210>  64
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N'-terminal truncated 3-hydroxy-3-methylglutaryl-coenzyme A 
       reductase

<400>  64

Met Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe Thr Ala 
1               5                   10                  15      


Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr Val Ile 
            20                  25                  30          


Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser Ser Ser 
        35                  40                  45              


Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile Glu Ser 
    50                  55                  60                  


Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu Leu Ser 
65                  70                  75                  80  


Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala Leu Val 
                85                  90                  95      


Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu Gly Asp 
            100                 105                 110         


Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile Leu Ala 
        115                 120                 125             


Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn Tyr Asp 
    130                 135                 140                 


Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr Met 
145                 150                 155                 160 


Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly Thr Ser 
                165                 170                 175     


Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Ala 
            180                 185                 190         


Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr Val 
        195                 200                 205             


Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro Thr 
    210                 215                 220                 


Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu Gly 
225                 230                 235                 240 


Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg 
                245                 250                 255     


Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met Arg 
            260                 265                 270         


Phe Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys 
        275                 280                 285             


Gly Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp Glu 
    290                 295                 300                 


Asp Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys 
305                 310                 315                 320 


Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala 
                325                 330                 335     


Glu Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys Ser Asp 
            340                 345                 350         


Val Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val Gly Ser 
        355                 360                 365             


Ala Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn Leu 
    370                 375                 380                 


Val Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn Val 
385                 390                 395                 400 


Glu Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp Leu 
                405                 410                 415     


Arg Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly 
            420                 425                 430         


Gly Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly Val 
        435                 440                 445             


Arg Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln Leu Ala 
    450                 455                 460                 


Arg Ile Val Ala Cys Ala Val Leu Ala Glu Leu Ser Leu Cys Ala Ala 
465                 470                 475                 480 


Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn Arg Lys 
                485                 490                 495     


Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr Asp Ile Asn 
            500                 505                 510         


Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 


