                         SEQUENCE LISTING

<110>  GenoScience Pharma
       Centre National de la Recherche Scientifique (CNRS)
       Universite Montpellier 2 (UM2)
       GROS, Edwige
       FOURAR, Monia
       DIVITA, Gilles
       HALFON, Philippe
 
<120>  PEPTIDE-BASED HIV PRE-INTEGRATION COMPLEX INHIBITORS

<130>  28344-WO-11

<150>  US 61/487,226
<151>  2011-05-17

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  replace by Thr, Ser, or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  replace by Lys or Arg

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  replace by Thr or Ser

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  replace by Glu or Arg

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  replace by Trp or Phe

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  replace by Thr, Arg, or Ser

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  replace by Trp or Phe

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  replace by Ala, Leu or is absent

<400>  1

Xaa Xaa Trp Leu Xaa Xaa Trp Ile Pro Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-255)

<400>  2

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala Cys 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-256)

<400>  3

Thr Arg Trp Leu Thr Glu Trp Ile Pro Trp Arg Trp Ala Cys 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-257)

<400>  4

Ser Arg Trp Leu Ser Arg Trp Ile Pro Trp Ser Trp Ala Cys 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-258)

<400>  5

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Leu Cys 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-259)

<400>  6

Thr Lys Trp Leu Thr Glu Trp Ile Pro Phe Thr Phe Ala Cys 
1               5                   10                  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-260)


<220>
<221>  DISULFID
<222>  (1)..(15)
<223>  cyclic peptide with disulfide bond

<400>  7

Cys Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala Cys 
1               5                   10                  15  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-261)


<220>
<221>  DISULFID
<222>  (1)..(14)
<223>  cyclic peptide with disulfide bond

<400>  8

Cys Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala Cys 
1               5                   10                  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-265)

<400>  9

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-267)


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  cyclic peptide with lactam bridge

<400>  10

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala 
1               5                   10              


<210>  11
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-268)


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  cyclic peptide with lactam bridge

<400>  11

Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp 
1               5                   10      


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-269)


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  cyclic peptide with lactam bridge

<400>  12

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp 
1               5                   10          


<210>  13
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-270)


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  cyclic peptide with lactam bridge

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-amino acid

<400>  13

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala 
1               5                   10              


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-271)


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  cyclic peptide with lactam bridge

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D-amino acid

<400>  14

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-272)


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  cyclic peptide with lactam bridge

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-amino acid

<400>  15

Thr Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-299)

<400>  16

Lys Trp Leu Thr Glu Trp Ile Pro Trp Thr Trp Ala 
1               5                   10          


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide derived from HIV-1 reverse transcriptase (GNS-300)


<220>
<221>  DISULFID
<222>  (1)..(15)
<223>  cyclic peptide with disulfide bond

<400>  17

Cys Thr Arg Trp Leu Thr Glu Trp Ile Pro Trp Arg Trp Ala Cys 
1               5                   10                  15  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  scrambled peptide 1 (GNS-Scr1)

<400>  18

Leu Thr Glu Trp Thr Trp Ala Trp Ile Pro Lys Trp Thr Cys 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  scrambled peptide 2 (GNS-Scr2)

<400>  19

Thr Lys Leu Ala Thr Glu Ile Trp Pro Thr Trp Ala Ala Cys 
1               5                   10                  


<210>  20
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  peptide carrier (Pep-1)


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  c-terminal cysteamide moiety

<400>  20

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide carrier (Pep-3)


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  c-terminal cysteamide moiety

<400>  21

Lys Trp Phe Glu Thr Trp Phe Thr Glu Trp Pro Lys Lys Arg Lys 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide carrier (Pep-3a)


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  c-terminal cysteamide moiety

<400>  22

Lys Trp Phe Glu Thr Trp Phe Thr Glu Trp Pro Lys Arg Arg Lys 
1               5                   10                  15  


<210>  23
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer strand

<400>  23
tccctgttcg ggcgccact                                                    19


<210>  24
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  template strand

<400>  24
tgtggaaaat ctcatgcagt ggcgcccgaa caggga                                 36


