                         SEQUENCE LISTING

<110>  Bayer Intellectual Property GmbH
 
<120>  Use of cathepsin K inhibition for the treatment and/or prophylxis
        of pulmonary hypertension and/or heart failure

<130>  BHC 11 1 014

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  990
<212>  DNA
<213>  Cavia porcellus

<400>  1
atgtgggggc tcaaggttct gctgctgcct gtggtgagct ttgctctgta ccctgaggag       60

atactggaca ctcagtggga gctttggaag aagacctaca ggaagcagta caatggcaag      120

gtggatgaaa tctctcggcg cataatttgg gaaaagaatc tgaaatatat ttccatccat      180

aaccttgagg cctctcttgg tgtccataca tatgaactga gcatgaacca cttgggagac      240

atgaccagtg aagaagtggt tcagaagatg actgggctca aagtacctcc ctctcattct      300

cacagtaatg ataccctgta catcccagac tgggaaggca gggctcctga ttctgttgac      360

taccgaaaga agggctatgt tactcccgtc aaaaaccagg gtcagtgtgg ttcctgttgg      420

gctttcagct ctgtgggtgc cctcgagggc cagctcaaga agaaaacagg caaactctta      480

aatctgagcc cccagaatct ggtggattgt gtatctgaga atgatggctg tggaggtggc      540

tatatgacca acgcctttca gtatgtgcaa gagaaccgtg gcattgactc tgaggacgcc      600

tatccctacg tgggccagga ggaaagctgt atgtacaatc caacaggcaa ggctgctaaa      660

tgccgcgggt atagagagat ccctgtgggc aatgagaagg cgctgaaaag agctgtggcc      720

cgcgtgggac ccgtctctgt ggccattgat gcaagcctga gctccttcca gttctacagc      780

aagggtgtgt attatgatga aagctgcaat ggtgaggatc tgaatcatgc actgctggca      840

gtgggatatg ggatgcagag aggaaataag cactggatac ttaaaaacag ctggggagaa      900

aactggggaa acaaaggcta tgttctcttg gctcgaaata agaacaatgc atgtggcatt      960

gccaacctcg ccagctttcc caagatgtga                                       990


<210>  2
<211>  329
<212>  PRT
<213>  Cavia porcellus

<400>  2

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr Gln Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


Tyr Arg Lys Gln Tyr Asn Gly Lys Val Asp Glu Ile Ser Arg Arg Ile 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ser Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Pro Ser His Ser His Ser Asn Asp Thr Leu Tyr Ile Pro Asp Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Glu Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Val Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Ser Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Gly Glu 
            260                 265                 270         


Asp Leu Asn His Ala Leu Leu Ala Val Gly Tyr Gly Met Gln Arg Gly 
        275                 280                 285             


Asn Lys His Trp Ile Leu Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Val Leu Leu Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  3
<211>  20
<212>  DNA
<213>  Cavia porcellus

<400>  3
tgagaatgat ggctgtggag                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Cavia porcellus

<400>  4
gtcaatgcca cggttctctt                                                   20


<210>  5
<211>  25
<212>  DNA
<213>  Cavia porcellus

<400>  5
atgaccaacg cctttcagta tgtgc                                             25


<210>  6
<211>  18
<212>  DNA
<213>  Cavia porcellus

<400>  6
gagtctgcgc aggtccag                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  Cavia porcellus

<400>  7
ctgctctggg ctccaatc                                                     18


<210>  8
<211>  21
<212>  DNA
<213>  Cavia porcellus

<400>  8
cttcggaggc cggatggaca g                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Cavia porcellus

<400>  9
gtgagaatgg acgctgtgtg                                                   20


<210>  10
<211>  18
<212>  DNA
<213>  Cavia porcellus

<400>  10
aagccctcga agcagtca                                                     18


<210>  11
<211>  21
<212>  DNA
<213>  Cavia porcellus

<400>  11
cgtgcgggag ggctacacct g                                                 21


<210>  12
<211>  18
<212>  DNA
<213>  Cavia porcellus

<400>  12
tgtcttcccc tccatcgt                                                     18


<210>  13
<211>  20
<212>  DNA
<213>  Cavia porcellus

<400>  13
ttctggccca tgcctaccat                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Cavia porcellus

<400>  14
aagatctggc ccttgaacct                                                   20


<210>  15
<211>  19
<212>  DNA
<213>  Canis familiaris

<400>  15
ggcaccagtc agaccgata                                                    19


<210>  16
<211>  20
<212>  DNA
<213>  Canis familiaris

<400>  16
cctattgtca atgcctctgg                                                   20


<210>  17
<211>  25
<212>  DNA
<213>  Canis familiaris

<400>  17
caaaattaag cgcaactggc ggaaa                                             25


<210>  18
<211>  19
<212>  DNA
<213>  Canis familiaris

<400>  18
ggggagaaaa ctggggaaa                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Canis familiaris

<400>  19
gccgcaagcg ttgttctta                                                    19


<210>  20
<211>  26
<212>  DNA
<213>  Canis familiaris

<400>  20
aaaggctata tcctcatggc tcggaa                                            26


<210>  21
<211>  20
<212>  DNA
<213>  Canis familiaris

<400>  21
ttggaggaca agatgccttt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Canis familiaris

<400>  22
cttccgcatt ctgctcactc                                                   20


<210>  23
<211>  25
<212>  DNA
<213>  Canis familiaris

<400>  23
aagatgaagc cgagtctccc caagc                                             25


