                         SEQUENCE LISTING

<110>  The Cleveland Clinic Foundation
       de la MOTTE, Carol
       Kessler, Sean
 
<120>  COMPOSITION AND METHOD TO IMPROVE INTESTINAL HEALTH

<130>  44929-221241

<150>  61/484,044
<151>  2011-05-09

<150>  61/609,657
<151>  2012-03-12

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  2
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala 
1               5                   10                  15      


Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro 
            20                  25                  30          


Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala 
        35                  40                  45              


Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile 
    50                  55                  60                  


Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu 
65                  70                  75                  80  


Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val Ala 
                85                  90                  95      


Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu 
            100                 105                 110         


Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val Pro 
        115                 120                 125             


Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu Pro 
    130                 135                 140                 


Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro Gly 
145                 150                 155                 160 


Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly Thr 
                165                 170                 175     


Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser Tyr 
            180                 185                 190         


Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala Phe 
        195                 200                 205             


Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu Arg 
    210                 215                 220                 


Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val Asp 
225                 230                 235                 240 


Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His Ala Val Val 
                245                 250                 255     


Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu Arg 
            260                 265                 270         


Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln Leu 
        275                 280                 285             


Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser Ala 
    290                 295                 300                 


Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr Leu 
305                 310                 315                 320 


Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys Ser Glu Glu 
                325                 330                 335     


Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala Val Gly Glu 
            340                 345                 350         


Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser Glu Gly Ser 
        355                 360                 365             


Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile Ala Leu Val 
    370                 375                 380                 


Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val Tyr 
385                 390                 395                 400 


Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Lys 
                405                 410                 415     


Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro Val 
            420                 425                 430         


Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser Leu 
        435                 440                 445             


Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val Asp 
    450                 455                 460                 


Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln Thr 
465                 470                 475                 480 


Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro Gly 
                485                 490                 495     


Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu Gln 
            500                 505                 510         


Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr 
        515                 520                 525             


Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala Phe 
    530                 535                 540                 


Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn Glu 
545                 550                 555                 560 


Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys Leu 
                565                 570                 575     


Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu Ala 
            580                 585                 590         


Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu Arg 
        595                 600                 605             


Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn Gly 
    610                 615                 620                 


Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys Asn 
625                 630                 635                 640 


Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly Lys 
                645                 650                 655     


Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile Thr 
            660                 665                 670         


Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu Phe 
        675                 680                 685             


Leu Arg Lys 
    690     


<210>  3
<211>  707
<212>  PRT
<213>  Mus musculus

<400>  3

Met Arg Leu Leu Ile Pro Ser Leu Ile Phe Leu Glu Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Lys Ala Thr Thr Val Gln Trp Cys Ala Val Ser Asn Ser 
            20                  25                  30          


Glu Glu Glu Lys Cys Leu Arg Trp Gln Asn Glu Met Arg Lys Val Gly 
        35                  40                  45              


Gly Pro Pro Leu Ser Cys Val Lys Lys Ser Ser Thr Arg Gln Cys Ile 
    50                  55                  60                  


Gln Ala Ile Val Thr Asn Arg Ala Asp Ala Met Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Thr Met Phe Asp Ala Gly Lys Pro Pro Tyr Lys Leu Arg Pro Val Ala 
                85                  90                  95      


Ala Glu Val Tyr Gly Thr Lys Glu Gln Pro Arg Thr His Tyr Tyr Ala 
            100                 105                 110         


Val Ala Val Val Lys Asn Ser Ser Asn Phe His Leu Asn Gln Leu Gln 
        115                 120                 125             


Gly Leu Arg Ser Cys His Thr Gly Ile Gly Arg Ser Ala Gly Trp Lys 
    130                 135                 140                 


Ile Pro Ile Gly Thr Leu Arg Pro Tyr Leu Asn Trp Asn Gly Pro Pro 
145                 150                 155                 160 


Ala Ser Leu Glu Glu Ala Val Ser Lys Phe Phe Ser Lys Ser Cys Val 
                165                 170                 175     


Pro Gly Ala Gln Lys Asp Arg Phe Pro Asn Leu Cys Ser Ser Cys Ala 
            180                 185                 190         


Gly Thr Gly Ala Asn Lys Cys Ala Ser Ser Pro Glu Glu Pro Tyr Ser 
        195                 200                 205             


Gly Tyr Ala Gly Ala Leu Arg Cys Leu Arg Asp Asn Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Thr Arg Gly Ser Thr Val Phe Glu Glu Leu Pro Asn Lys Ala 
225                 230                 235                 240 


Glu Arg Asp Gln Tyr Lys Leu Leu Cys Pro Asp Asn Thr Trp Lys Pro 
                245                 250                 255     


Val Thr Glu Tyr Lys Glu Cys His Leu Ala Gln Val Pro Ser His Ala 
            260                 265                 270         


Val Val Ser Arg Ser Thr Asn Asp Lys Glu Glu Ala Ile Trp Glu Leu 
        275                 280                 285             


Leu Arg Gln Ser Gln Glu Lys Phe Gly Lys Lys Gln Ala Ser Gly Phe 
    290                 295                 300                 


Gln Leu Phe Ala Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Glu 
305                 310                 315                 320 


Ser Ala Ile Gly Phe Val Arg Val Pro Gln Lys Val Asp Val Gly Leu 
                325                 330                 335     


Tyr Leu Thr Phe Ser Tyr Thr Thr Ser Ile Gln Asn Leu Asn Lys Lys 
            340                 345                 350         


Gln Gln Asp Val Ile Ala Ser Lys Ala Arg Val Thr Trp Cys Ala Val 
        355                 360                 365             


Gly Ser Glu Glu Lys Arg Lys Cys Asp Gln Trp Asn Arg Ala Ser Arg 
    370                 375                 380                 


Gly Arg Val Thr Cys Ile Ser Phe Pro Thr Thr Glu Asp Cys Ile Val 
385                 390                 395                 400 


Ala Ile Met Lys Gly Asp Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr 
                405                 410                 415     


Ile Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn 
            420                 425                 430         


Gln Lys Ser Ser Lys Ser Asn Gly Leu Asp Cys Val Asn Arg Pro Val 
        435                 440                 445             


Glu Gly Tyr Leu Ala Val Ala Ala Val Arg Arg Glu Asp Ala Gly Phe 
    450                 455                 460                 


Thr Trp Ser Ser Leu Arg Gly Lys Lys Ser Cys His Thr Ala Val Asp 
465                 470                 475                 480 


Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Ala Asn Gln Thr 
                485                 490                 495     


Arg Ser Cys Lys Phe Asn Glu Phe Phe Ser Gln Ser Cys Ala Pro Gly 
            500                 505                 510         


Ala Asp Pro Lys Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu Lys 
        515                 520                 525             


Gly Glu Asn Lys Cys Ala Pro Asn Ser Lys Glu Arg Tyr Gln Gly Tyr 
    530                 535                 540                 


Thr Gly Ala Leu Arg Cys Leu Ala Glu Lys Ala Gly Asn Val Ala Phe 
545                 550                 555                 560 


Leu Lys Asp Ser Thr Val Leu Gln Asn Thr Asp Gly Lys Asn Thr Glu 
                565                 570                 575     


Glu Trp Ala Arg Asn Leu Lys Leu Lys Asp Phe Glu Leu Leu Cys Leu 
            580                 585                 590         


Asp Asp Thr Arg Lys Pro Val Thr Glu Ala Lys Asn Cys His Leu Ala 
        595                 600                 605             


Ile Ala Pro Asn His Ala Val Val Ser Arg Thr Asp Lys Val Glu Val 
    610                 615                 620                 


Leu Gln Gln Val Leu Leu Asp Gln Gln Val Gln Phe Gly Arg Asn Gly 
625                 630                 635                 640 


Gln Arg Cys Pro Gly Glu Phe Cys Leu Phe Gln Ser Lys Thr Lys Asn 
                645                 650                 655     


Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Lys Ile Pro Gly Lys 
            660                 665                 670         


Thr Thr Ser Glu Lys Tyr Leu Gly Lys Glu Tyr Val Ile Ala Thr Glu 
        675                 680                 685             


Arg Leu Lys Gln Cys Ser Ser Ser Pro Leu Leu Glu Ala Cys Ala Phe 
    690                 695                 700                 


Leu Thr Gln 
705         


<210>  4
<211>  688
<212>  PRT
<213>  Mus musculus

<400>  4

Lys Ala Thr Thr Val Gln Trp Cys Ala Val Ser Asn Ser Glu Glu Glu 
1               5                   10                  15      


Lys Cys Leu Arg Trp Gln Asn Glu Met Arg Lys Val Gly Gly Pro Pro 
            20                  25                  30          


Leu Ser Cys Val Lys Lys Ser Ser Thr Arg Gln Cys Ile Gln Ala Ile 
        35                  40                  45              


Val Thr Asn Arg Ala Asp Ala Met Thr Leu Asp Gly Gly Thr Met Phe 
    50                  55                  60                  


Asp Ala Gly Lys Pro Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu Val 
65                  70                  75                  80  


Tyr Gly Thr Lys Glu Gln Pro Arg Thr His Tyr Tyr Ala Val Ala Val 
                85                  90                  95      


Val Lys Asn Ser Ser Asn Phe His Leu Asn Gln Leu Gln Gly Leu Arg 
            100                 105                 110         


Ser Cys His Thr Gly Ile Gly Arg Ser Ala Gly Trp Lys Ile Pro Ile 
        115                 120                 125             


Gly Thr Leu Arg Pro Tyr Leu Asn Trp Asn Gly Pro Pro Ala Ser Leu 
    130                 135                 140                 


Glu Glu Ala Val Ser Lys Phe Phe Ser Lys Ser Cys Val Pro Gly Ala 
145                 150                 155                 160 


Gln Lys Asp Arg Phe Pro Asn Leu Cys Ser Ser Cys Ala Gly Thr Gly 
                165                 170                 175     


Ala Asn Lys Cys Ala Ser Ser Pro Glu Glu Pro Tyr Ser Gly Tyr Ala 
            180                 185                 190         


Gly Ala Leu Arg Cys Leu Arg Asp Asn Ala Gly Asp Val Ala Phe Thr 
        195                 200                 205             


Arg Gly Ser Thr Val Phe Glu Glu Leu Pro Asn Lys Ala Glu Arg Asp 
    210                 215                 220                 


Gln Tyr Lys Leu Leu Cys Pro Asp Asn Thr Trp Lys Pro Val Thr Glu 
225                 230                 235                 240 


Tyr Lys Glu Cys His Leu Ala Gln Val Pro Ser His Ala Val Val Ser 
                245                 250                 255     


Arg Ser Thr Asn Asp Lys Glu Glu Ala Ile Trp Glu Leu Leu Arg Gln 
            260                 265                 270         


Ser Gln Glu Lys Phe Gly Lys Lys Gln Ala Ser Gly Phe Gln Leu Phe 
        275                 280                 285             


Ala Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Glu Ser Ala Ile 
    290                 295                 300                 


Gly Phe Val Arg Val Pro Gln Lys Val Asp Val Gly Leu Tyr Leu Thr 
305                 310                 315                 320 


Phe Ser Tyr Thr Thr Ser Ile Gln Asn Leu Asn Lys Lys Gln Gln Asp 
                325                 330                 335     


Val Ile Ala Ser Lys Ala Arg Val Thr Trp Cys Ala Val Gly Ser Glu 
            340                 345                 350         


Glu Lys Arg Lys Cys Asp Gln Trp Asn Arg Ala Ser Arg Gly Arg Val 
        355                 360                 365             


Thr Cys Ile Ser Phe Pro Thr Thr Glu Asp Cys Ile Val Ala Ile Met 
    370                 375                 380                 


Lys Gly Asp Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Ile Tyr Thr 
385                 390                 395                 400 


Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Gln Lys Ser 
                405                 410                 415     


Ser Lys Ser Asn Gly Leu Asp Cys Val Asn Arg Pro Val Glu Gly Tyr 
            420                 425                 430         


Leu Ala Val Ala Ala Val Arg Arg Glu Asp Ala Gly Phe Thr Trp Ser 
        435                 440                 445             


Ser Leu Arg Gly Lys Lys Ser Cys His Thr Ala Val Asp Arg Thr Ala 
    450                 455                 460                 


Gly Trp Asn Ile Pro Met Gly Leu Leu Ala Asn Gln Thr Arg Ser Cys 
465                 470                 475                 480 


Lys Phe Asn Glu Phe Phe Ser Gln Ser Cys Ala Pro Gly Ala Asp Pro 
                485                 490                 495     


Lys Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu Lys Gly Glu Asn 
            500                 505                 510         


Lys Cys Ala Pro Asn Ser Lys Glu Arg Tyr Gln Gly Tyr Thr Gly Ala 
        515                 520                 525             


Leu Arg Cys Leu Ala Glu Lys Ala Gly Asn Val Ala Phe Leu Lys Asp 
    530                 535                 540                 


Ser Thr Val Leu Gln Asn Thr Asp Gly Lys Asn Thr Glu Glu Trp Ala 
545                 550                 555                 560 


Arg Asn Leu Lys Leu Lys Asp Phe Glu Leu Leu Cys Leu Asp Asp Thr 
                565                 570                 575     


Arg Lys Pro Val Thr Glu Ala Lys Asn Cys His Leu Ala Ile Ala Pro 
            580                 585                 590         


Asn His Ala Val Val Ser Arg Thr Asp Lys Val Glu Val Leu Gln Gln 
        595                 600                 605             


Val Leu Leu Asp Gln Gln Val Gln Phe Gly Arg Asn Gly Gln Arg Cys 
    610                 615                 620                 


Pro Gly Glu Phe Cys Leu Phe Gln Ser Lys Thr Lys Asn Leu Leu Phe 
625                 630                 635                 640 


Asn Asp Asn Thr Glu Cys Leu Ala Lys Ile Pro Gly Lys Thr Thr Ser 
                645                 650                 655     


Glu Lys Tyr Leu Gly Lys Glu Tyr Val Ile Ala Thr Glu Arg Leu Lys 
            660                 665                 670         


Gln Cys Ser Ser Ser Pro Leu Leu Glu Ala Cys Ala Phe Leu Thr Gln 
        675                 680                 685             


