                         SEQUENCE LISTING

<110>  Li, Yang
       Wu, Xinle
       Ge, Hongfei
       Baribault, Helene
       Lemon, Bryan
       Sheng, Jeqi
       Vonderfecht, Steven
       Weiszmann, Jennifer V
       Gardner, Jonitha
       Lee, Ki Jeong
 
<120>  METHOD OF IDENTIFYING COMPOUNDS THAT SPECIFICALLY MODULATE THE 
       INTERACTION OF FGFR1 AND  BETA-KLOTHO

<130>  A-1623-US-PSP

<150>  US 61/484,585
<151>  2011-05-10

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  3132
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3132)

<400>  1
atg aag cca ggc tgt gcg gca gga tct cca ggg aat gaa tgg att ttc         48
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe           
1               5                   10                  15                

ttc agc act gat gaa ata acc aca cgc tat agg aat aca atg tcc aac         96
Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn           
            20                  25                  30                    

ggg gga ttg caa aga tct gtc atc ctg tca gca ctt att ctg cta cga        144
Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg           
        35                  40                  45                        

gct gtt act gga ttc tct gga gat gga aga gct ata tgg tct aaa aat        192
Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn           
    50                  55                  60                            

cct aat ttt act ccg gta aat gaa agt cag ctg ttt ctc tat gac act        240
Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr           
65                  70                  75                  80            

ttc cct aaa aac ttt ttc tgg ggt att ggg act gga gca ttg caa gtg        288
Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val           
                85                  90                  95                

gaa ggg agt tgg aag aag gat gga aaa gga cct tct ata tgg gat cat        336
Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His           
            100                 105                 110                   

ttc atc cac aca cac ctt aaa aat gtc agc agc acg aat ggt tcc agt        384
Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser           
        115                 120                 125                       

gac agt tat att ttt ctg gaa aaa gac tta tca gcc ctg gat ttt ata        432
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile           
    130                 135                 140                           

gga gtt tct ttt tat caa ttt tca att tcc tgg cca agg ctt ttc ccc        480
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro           
145                 150                 155                 160           

gat gga ata gta aca gtt gcc aac gca aaa ggt ctg cag tac tac agt        528
Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser           
                165                 170                 175               

act ctt ctg gac gct cta gtg ctt aga aac att gaa cct ata gtt act        576
Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr           
            180                 185                 190                   

tta tac cac tgg gat ttg cct ttg gca cta caa gaa aaa tat ggg ggg        624
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly           
        195                 200                 205                       

tgg aaa aat gat acc ata ata gat atc ttc aat gac tat gcc aca tac        672
Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr           
    210                 215                 220                           

tgt ttc cag atg ttt ggg gac cgt gtc aaa tat tgg att aca att cac        720
Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His           
225                 230                 235                 240           

aac cca tat cta gtg gct tgg cat ggg tat ggg aca ggt atg cat gcc        768
Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala           
                245                 250                 255               

cct gga gag aag gga aat tta gca gct gtc tac act gtg gga cac aac        816
Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn           
            260                 265                 270                   

ttg atc aag gct cac tcg aaa gtt tgg cat aac tac aac aca cat ttc        864
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe           
        275                 280                 285                       

cgc cca cat cag aag ggt tgg tta tcg atc acg ttg gga tct cat tgg        912
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp           
    290                 295                 300                           

atc gag cca aac cgg tcg gaa aac acg atg gat ata ttc aaa tgt caa        960
Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln           
305                 310                 315                 320           

caa tcc atg gtt tct gtg ctt gga tgg ttt gcc aac cct atc cat ggg       1008
Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly           
                325                 330                 335               

gat ggc gac tat cca gag ggg atg aga aag aag ttg ttc tcc gtt cta       1056
Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu           
            340                 345                 350                   

ccc att ttc tct gaa gca gag aag cat gag atg aga ggc aca gct gat       1104
Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp           
        355                 360                 365                       

ttc ttt gcc ttt tct ttt gga ccc aac aac ttc aag ccc cta aac acc       1152
Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr           
    370                 375                 380                           

atg gct aaa atg gga caa aat gtt tca ctt aat tta aga gaa gcg ctg       1200
Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu           
385                 390                 395                 400           

aac tgg att aaa ctg gaa tac aac aac cct cga atc ttg att gct gag       1248
Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu           
                405                 410                 415               

aat ggc tgg ttc aca gac agt cgt gtg aaa aca gaa gac acc acg gcc       1296
Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala           
            420                 425                 430                   

atc tac atg atg aag aat ttc ctc agc cag gtg ctt caa gca ata agg       1344
Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg           
        435                 440                 445                       

tta gat gaa ata cga gtg ttt ggt tat act gcc tgg tct ctc ctg gat       1392
Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp           
    450                 455                 460                           

ggc ttt gaa tgg cag gat gct tac acc atc cgc cga gga tta ttt tat       1440
Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr           
465                 470                 475                 480           

gtg gat ttt aac agt aaa cag aaa gag cgg aaa cct aag tct tca gca       1488
Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala           
                485                 490                 495               

cac tac tac aaa cag atc ata cga gaa aat ggt ttt tct tta aaa gag       1536
His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu           
            500                 505                 510                   

tcc acg cca gat gtg cag ggc cag ttt ccc tgt gac ttc tcc tgg ggt       1584
Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly           
        515                 520                 525                       

gtc act gaa tct gtt ctt aag ccc gag tct gtg gct tcg tcc cca cag       1632
Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln           
    530                 535                 540                           

ttc agc gat cct cat ctg tac gtg tgg aac gcc act ggc aac aga ctg       1680
Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu           
545                 550                 555                 560           

ttg cac cga gtg gaa ggg gtg agg ctg aaa aca cga ccc gct caa tgc       1728
Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys           
                565                 570                 575               

aca gat ttt gta aac atc aaa aaa caa ctt gag atg ttg gca aga atg       1776
Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met           
            580                 585                 590                   

aaa gtc acc cac tac cgg ttt gct ctg gat tgg gcc tcg gtc ctt ccc       1824
Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro           
        595                 600                 605                       

act ggc aac ctg tcc gcg gtg aac cga cag gcc ctg agg tac tac agg       1872
Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg           
    610                 615                 620                           

tgc gtg gtc agt gag ggg ctg aag ctt ggc atc tcc gcg atg gtc acc       1920
Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr           
625                 630                 635                 640           

ctg tat tat ccg acc cac gcc cac cta ggc ctc ccc gag cct ctg ttg       1968
Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu           
                645                 650                 655               

cat gcc gac ggg tgg ctg aac cca tcg acg gcc gag gcc ttc cag gcc       2016
His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala           
            660                 665                 670                   

tac gct ggg ctg tgc ttc cag gag ctg ggg gac ctg gtg aag ctc tgg       2064
Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp           
        675                 680                 685                       

atc acc atc aac gag cct aac cgg cta agt gac atc tac aac cgc tct       2112
Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser           
    690                 695                 700                           

ggc aac gac acc tac ggg gcg gcg cac aac ctg ctg gtg gcc cac gcc       2160
Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala           
705                 710                 715                 720           

ctg gcc tgg cgc ctc tac gac cgg cag ttc agg ccc tca cag cgc ggg       2208
Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly           
                725                 730                 735               

gcc gtg tcg ctg tcg ctg cac gcg gac tgg gcg gaa ccc gcc aac ccc       2256
Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro           
            740                 745                 750                   

tat gct gac tcg cac tgg agg gcg gcc gag cgc ttc ctg cag ttc gag       2304
Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu           
        755                 760                 765                       

atc gcc tgg ttc gcc gag ccg ctc ttc aag acc ggg gac tac ccc gcg       2352
Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala           
    770                 775                 780                           

gcc atg agg gaa tac att gcc tcc aag cac cga cgg ggg ctt tcc agc       2400
Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser           
785                 790                 795                 800           

tcg gcc ctg ccg cgc ctc acc gag gcc gaa agg agg ctg ctc aag ggc       2448
Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly           
                805                 810                 815               

acg gtc gac ttc tgc gcg ctc aac cac ttc acc act agg ttc gtg atg       2496
Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met           
            820                 825                 830                   

cac gag cag ctg gcc ggc agc cgc tac gac tcg gac agg gac atc cag       2544
His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln           
        835                 840                 845                       

ttt ctg cag gac atc acc cgc ctg agc tcc ccc acg cgc ctg gct gtg       2592
Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val           
    850                 855                 860                           

att ccc tgg ggg gtg cgc aag ctg ctg cgg tgg gtc cgg agg aac tac       2640
Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr           
865                 870                 875                 880           

ggc gac atg gac att tac atc acc gcc agt ggc atc gac gac cag gct       2688
Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala           
                885                 890                 895               

ctg gag gat gac cgg ctc cgg aag tac tac cta ggg aag tac ctt cag       2736
Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln           
            900                 905                 910                   

gag gtg ctg aaa gca tac ctg att gat aaa gtc aga atc aaa ggc tat       2784
Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr           
        915                 920                 925                       

tat gca ttc aaa ctg gct gaa gag aaa tct aaa ccc aga ttt gga ttc       2832
Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe           
    930                 935                 940                           

ttc aca tct gat ttt aaa gct aaa tcc tca ata caa ttt tac aac aaa       2880
Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys           
945                 950                 955                 960           

gtg atc agc agc agg ggc ttc cct ttt gag aac agt agt tct aga tgc       2928
Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys           
                965                 970                 975               

agt cag acc caa gaa aat aca gag tgc act gtc tgc tta ttc ctt gtg       2976
Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val           
            980                 985                 990                   

cag aag aaa cca ctg ata ttc ctg  ggt tgt tgc ttc ttc  tcc acc ctg     3024
Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu         
        995                 1000                 1005                     

gtt cta  ctc tta tca att gcc  att ttt caa agg cag  aag aga aga        3069
Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg            
    1010                 1015                 1020                        

aag ttt  tgg aaa gca aaa aac  tta caa cac ata cca  tta aag aaa        3114
Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys            
    1025                 1030                 1035                        

ggc aag  aga gtt gtt agc                                              3132
Gly Lys  Arg Val Val Ser                                                  
    1040                                                                  


<210>  2
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  3
<211>  2466
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(2466)

<400>  3
atg tgg agc tgg aag tgc ctc ctc ttc tgg gct gtg ctg gtc aca gcc         48
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala           
1               5                   10                  15                

aca ctc tgc acc gct agg ccg tcc ccg acc ttg cct gaa caa gcc cag         96
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln           
            20                  25                  30                    

ccc tgg gga gcc cct gtg gaa gtg gag tcc ttc ctg gtc cac ccc ggt        144
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly           
        35                  40                  45                        

gac ctg ctg cag ctt cgc tgt cgg ctg cgg gac gat gtg cag agc atc        192
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile           
    50                  55                  60                            

aac tgg ctg cgg gac ggg gtg cag ctg gcg gaa agc aac cgc acc cgc        240
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg           
65                  70                  75                  80            

atc aca ggg gag gag gtg gag gtg cag gac tcc gtg ccc gca gac tcc        288
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser           
                85                  90                  95                

ggc ctc tat gct tgc gta acc agc agc ccc tcg ggc agt gac acc acc        336
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr           
            100                 105                 110                   

tac ttc tcc gtc aat gtt tca gat gct ctc ccc tcc tcg gag gat gat        384
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp           
        115                 120                 125                       

gat gat gat gat gac tcc tct tca gag gag aaa gaa aca gat aac acc        432
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr           
    130                 135                 140                           

aaa cca aac cgt atg ccc gta gct cca tat tgg aca tca cca gaa aag        480
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys           
145                 150                 155                 160           

atg gaa aag aaa ttg cat gca gtg ccg gct gcc aag aca gtg aag ttc        528
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe           
                165                 170                 175               

aaa tgc cct tcc agt ggg aca cca aac cca aca ctg cgc tgg ttg aaa        576
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys           
            180                 185                 190                   

aat ggc aaa gaa ttc aaa cct gac cac aga att gga ggc tac aag gtc        624
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val           
        195                 200                 205                       

cgt tat gcc acc tgg agc atc ata atg gac tct gtg gtg ccc tct gac        672
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp           
    210                 215                 220                           

aag ggc aac tac acc tgc att gtg gag aat gag tac ggc agc atc aac        720
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn           
225                 230                 235                 240           

cac aca tac cag ctg gat gtc gtg gag cgg tcc cct cac cgg ccc atc        768
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile           
                245                 250                 255               

ctg caa gca ggg ttg ccc gcc aac aaa aca gtg gcc ctg ggt agc aac        816
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn           
            260                 265                 270                   

gtg gag ttc atg tgt aag gtg tac agt gac ccg cag ccg cac atc cag        864
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln           
        275                 280                 285                       

tgg cta aag cac atc gag gtg aat ggg agc aag att ggc cca gac aac        912
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn           
    290                 295                 300                           

ctg cct tat gtc cag atc ttg aag act gct gga gtt aat acc acc gac        960
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp           
305                 310                 315                 320           

aaa gag atg gag gtg ctt cac tta aga aat gtc tcc ttt gag gac gca       1008
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala           
                325                 330                 335               

ggg gag tat acg tgc ttg gcg ggt aac tct atc gga ctc tcc cat cac       1056
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His           
            340                 345                 350                   

tct gca tgg ttg acc gtt ctg gaa gcc ctg gaa gag agg ccg gca gtg       1104
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val           
        355                 360                 365                       

atg acc tcg ccc ctg tac ctg gag atc atc atc tat tgc aca ggg gcc       1152
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala           
    370                 375                 380                           

ttc ctc atc tcc tgc atg gtg ggg tcg gtc atc gtc tac aag atg aag       1200
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys           
385                 390                 395                 400           

agt ggt acc aag aag agt gac ttc cac agc cag atg gct gtg cac aag       1248
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys           
                405                 410                 415               

ctg gcc aag agc atc cct ctg cgc aga cag gta aca gtg tct gct gac       1296
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp           
            420                 425                 430                   

tcc agt gca tcc atg aac tct ggg gtt ctt ctg gtt cgg cca tca cgg       1344
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg           
        435                 440                 445                       

ctc tcc tcc agt ggg act ccc atg cta gca ggg gtc tct gag tat gag       1392
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu           
    450                 455                 460                           

ctt ccc gaa gac cct cgc tgg gag ctg cct cgg gac aga ctg gtc tta       1440
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu           
465                 470                 475                 480           

ggc aaa ccc ctg gga gag ggc tgc ttt ggg cag gtg gtg ttg gca gag       1488
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu           
                485                 490                 495               

gct atc ggg ctg gac aag gac aaa ccc aac cgt gtg acc aaa gtg gct       1536
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala           
            500                 505                 510                   

gtg aag atg ttg aag tcg gac gca aca gag aaa gac ttg tca gac ctg       1584
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu           
        515                 520                 525                       

atc tca gaa atg gag atg atg aag atg atc ggg aag cat aag aat atc       1632
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile           
    530                 535                 540                           

atc aac ctg ctg ggg gcc tgc acg cag gat ggt ccc ttg tat gtc atc       1680
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile           
545                 550                 555                 560           

gtg gag tat gcc tcc aag ggc aac ctg cgg gag tac ctg cag gcc cgg       1728
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg           
                565                 570                 575               

agg ccc cca ggg ctg gaa tac tgc tac aac ccc agc cac aac cca gag       1776
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu           
            580                 585                 590                   

gag cag ctc tcc tcc aag gac ctg gtg tcc tgc gcc tac cag gtg gcc       1824
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala           
        595                 600                 605                       

cga ggc atg gag tat ctg gcc tcc aag aag tgc ata cac cga gac ctg       1872
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu           
    610                 615                 620                           

gca gcc agg aat gtc ctg gtg aca gag gac aat gtg atg aag ata gca       1920
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala           
625                 630                 635                 640           

gac ttt ggc ctc gca cgg gac att cac cac atc gac tac tat aaa aag       1968
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys           
                645                 650                 655               

aca acc aac ggc cga ctg cct gtg aag tgg atg gca ccc gag gca tta       2016
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu           
            660                 665                 670                   

ttt gac cgg atc tac acc cac cag agt gat gtg tgg tct ttc ggg gtg       2064
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val           
        675                 680                 685                       

ctc ctg tgg gag atc ttc act ctg ggc ggc tcc cca tac ccc ggt gtg       2112
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val           
    690                 695                 700                           

cct gtg gag gaa ctt ttc aag ctg ctg aag gag ggt cac cgc atg gac       2160
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp           
705                 710                 715                 720           

aag ccc agt aac tgc acc aac gag ctg tac atg atg atg cgg gac tgc       2208
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys           
                725                 730                 735               

tgg cat gca gtg ccc tca cag aga ccc acc ttc aag cag ctg gtg gaa       2256
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu           
            740                 745                 750                   

gac ctg gac cgc atc gtg gcc ttg acc tcc aac cag gag tac ctg gac       2304
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp           
        755                 760                 765                       

ctg tcc atg ccc ctg gac cag tac tcc ccc agc ttt ccc gac acc cgg       2352
Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg           
    770                 775                 780                           

agc tct acg tgc tcc tca ggg gag gat tcc gtc ttc tct cat gag ccg       2400
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro           
785                 790                 795                 800           

ctg ccc gag gag ccc tgc ctg ccc cga cac cca gcc cag ctt gcc aat       2448
Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn           
                805                 810                 815               

ggc gga ctc aaa cgc cgc                                               2466
Gly Gly Leu Lys Arg Arg                                                   
            820                                                           


<210>  4
<211>  822
<212>  PRT
<213>  homo sapiens

<400>  4

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  5
<211>  2472
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2472)

<400>  5
atg tgg agc tgg aag tgc ctc ctc ttc tgg gct gtg ctg gtc aca gcc         48
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala           
1               5                   10                  15                

aca ctc tgc acc gct agg ccg tcc ccg acc ttg cct gaa caa gcc cag         96
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln           
            20                  25                  30                    

ccc tgg gga gcc cct gtg gaa gtg gag tcc ttc ctg gtc cac ccc ggt        144
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly           
        35                  40                  45                        

gac ctg ctg cag ctt cgc tgt cgg ctg cgg gac gat gtg cag agc atc        192
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile           
    50                  55                  60                            

aac tgg ctg cgg gac ggg gtg cag ctg gcg gaa agc aac cgc acc cgc        240
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg           
65                  70                  75                  80            

atc aca ggg gag gag gtg gag gtg cag gac tcc gtg ccc gca gac tcc        288
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser           
                85                  90                  95                

ggc ctc tat gct tgc gta acc agc agc ccc tcg ggc agt gac acc acc        336
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr           
            100                 105                 110                   

tac ttc tcc gtc aat gtt tca gat gct ctc ccc tcc tcg gag gat gat        384
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp           
        115                 120                 125                       

gat gat gat gat gac tcc tct tca gag gag aaa gaa aca gat aac acc        432
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr           
    130                 135                 140                           

aaa cca aac cgt atg ccc gta gct cca tat tgg aca tca cca gaa aag        480
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys           
145                 150                 155                 160           

atg gaa aag aaa ttg cat gca gtg ccg gct gcc aag aca gtg aag ttc        528
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe           
                165                 170                 175               

aaa tgc cct tcc agt ggg aca cca aac cca aca ctg cgc tgg ttg aaa        576
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys           
            180                 185                 190                   

aat ggc aaa gaa ttc aaa cct gac cac aga att gga ggc tac aag gtc        624
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val           
        195                 200                 205                       

cgt tat gcc acc tgg agc atc ata atg gac tct gtg gtg ccc tct gac        672
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp           
    210                 215                 220                           

aag ggc aac tac acc tgc att gtg gag aat gag tac ggc agc atc aac        720
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn           
225                 230                 235                 240           

cac aca tac cag ctg gat gtc gtg gag cgg tcc cct cac cgg ccc atc        768
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile           
                245                 250                 255               

ctg caa gca ggg ttg ccc gcc aac aaa aca gtg gcc ctg ggt agc aac        816
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn           
            260                 265                 270                   

gtg gag ttc atg tgt aag gtg tac agt gac ccg cag ccg cac atc cag        864
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln           
        275                 280                 285                       

tgg cta aag cac atc gag gtg aat ggg agc aag att ggc cca gac aac        912
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn           
    290                 295                 300                           

ctg cct tat gtc cag atc ttg aag cat tcg ggg att aat agc tcg gat        960
Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp           
305                 310                 315                 320           

gcg gag gtg ctg acc ctg ttc aat gtg aca gag gcc cag agc ggg gag       1008
Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu           
                325                 330                 335               

tat gtg tgt aag gtt tcc aat tat att ggt gaa gct aac cag tct gcg       1056
Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala           
            340                 345                 350                   

tgg ctc act gtc acc aga cct gtg gca aaa gcc ctg gaa gag agg ccg       1104
Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro           
        355                 360                 365                       

gca gtg atg acc tcg ccc ctg tac ctg gag atc atc atc tat tgc aca       1152
Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr           
    370                 375                 380                           

ggg gcc ttc ctc atc tcc tgc atg gtg ggg tcg gtc atc gtc tac aag       1200
Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys           
385                 390                 395                 400           

atg aag agt ggt acc aag aag agt gac ttc cac agc cag atg gct gtg       1248
Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val           
                405                 410                 415               

cac aag ctg gcc aag agc atc cct ctg cgc aga cag gta aca gtg tct       1296
His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser           
            420                 425                 430                   

gct gac tcc agt gca tcc atg aac tct ggg gtt ctt ctg gtt cgg cca       1344
Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro           
        435                 440                 445                       

tca cgg ctc tcc tcc agt ggg act ccc atg cta gca ggg gtc tct gag       1392
Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu           
    450                 455                 460                           

tat gag ctt ccc gaa gac cct cgc tgg gag ctg cct cgg gac aga ctg       1440
Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu           
465                 470                 475                 480           

gtc tta ggc aaa ccc ctg gga gag ggc tgc ttt ggg cag gtg gtg ttg       1488
Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu           
                485                 490                 495               

gca gag gct atc ggg ctg gac aag gac aaa ccc aac cgt gtg acc aaa       1536
Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys           
            500                 505                 510                   

gtg gct gtg aag atg ttg aag tcg gac gca aca gag aaa gac ttg tca       1584
Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser           
        515                 520                 525                       

gac ctg atc tca gaa atg gag atg atg aag atg atc ggg aag cat aag       1632
Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys           
    530                 535                 540                           

aat atc atc aac ctg ctg ggg gcc tgc acg cag gat ggt ccc ttg tat       1680
Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr           
545                 550                 555                 560           

gtc atc gtg gag tat gcc tcc aag ggc aac ctg cgg gag tac ctg cag       1728
Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln           
                565                 570                 575               

gcc cgg agg ccc cca ggg ctg gaa tac tgc tac aac ccc agc cac aac       1776
Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn           
            580                 585                 590                   

cca gag gag cag ctc tcc tcc aag gac ctg gtg tcc tgc gcc tac cag       1824
Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln           
        595                 600                 605                       

gtg gcc cga ggc atg gag tat ctg gcc tcc aag aag tgc ata cac cga       1872
Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg           
    610                 615                 620                           

gac ctg gca gcc agg aat gtc ctg gtg aca gag gac aat gtg atg aag       1920
Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys           
625                 630                 635                 640           

ata gca gac ttt ggc ctc gca cgg gac att cac cac atc gac tac tat       1968
Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr           
                645                 650                 655               

aaa aag aca acc aac ggc cga ctg cct gtg aag tgg atg gca ccc gag       2016
Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu           
            660                 665                 670                   

gca tta ttt gac cgg atc tac acc cac cag agt gat gtg tgg tct ttc       2064
Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe           
        675                 680                 685                       

ggg gtg ctc ctg tgg gag atc ttc act ctg ggc ggc tcc cca tac ccc       2112
Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro           
    690                 695                 700                           

ggt gtg cct gtg gag gaa ctt ttc aag ctg ctg aag gag ggt cac cgc       2160
Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg           
705                 710                 715                 720           

atg gac aag ccc agt aac tgc acc aac gag ctg tac atg atg atg cgg       2208
Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg           
                725                 730                 735               

gac tgc tgg cat gca gtg ccc tca cag aga ccc acc ttc aag cag ctg       2256
Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu           
            740                 745                 750                   

gtg gaa gac ctg gac cgc atc gtg gcc ttg acc tcc aac cag gag tac       2304
Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr           
        755                 760                 765                       

ctg gac ctg tcc atg ccc ctg gac cag tac tcc ccc agc ttt ccc gac       2352
Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp           
    770                 775                 780                           

acc cgg agc tct acg tgc tcc tca ggg gag gat tcc gtc ttc tct cat       2400
Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His           
785                 790                 795                 800           

gag ccg ctg ccc gag gag ccc tgc ctg ccc cga cac cca gcc cag ctt       2448
Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu           
                805                 810                 815               

gcc aat ggc gga ctc aaa cgc cgc                                       2472
Ala Asn Gly Gly Leu Lys Arg Arg                                           
            820                                                           


<210>  6
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
305                 310                 315                 320 


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
                325                 330                 335     


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
        355                 360                 365             


Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr 
    370                 375                 380                 


Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys 
385                 390                 395                 400 


Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val 
                405                 410                 415     


His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro 
        435                 440                 445             


Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu 
    450                 455                 460                 


Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu 
465                 470                 475                 480 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu 
                485                 490                 495     


Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys 
            500                 505                 510         


Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser 
        515                 520                 525             


Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys 
    530                 535                 540                 


Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr 
545                 550                 555                 560 


Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln 
                565                 570                 575     


Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn 
            580                 585                 590         


Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln 
        595                 600                 605             


Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg 
    610                 615                 620                 


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys 
625                 630                 635                 640 


Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr 
                645                 650                 655     


Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
            660                 665                 670         


Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
        675                 680                 685             


Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
    690                 695                 700                 


Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg 
705                 710                 715                 720 


Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg 
                725                 730                 735     


Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
            740                 745                 750         


Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr 
        755                 760                 765             


Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp 
    770                 775                 780                 


Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His 
785                 790                 795                 800 


Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu 
                805                 810                 815     


Ala Asn Gly Gly Leu Lys Arg Arg 
            820                 


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Asp Ala Gln Gln Thr Glu 
1               5           


<210>  9
<211>  648
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(648)

<400>  9
atg cgg agc ggg tgt gtg gtg gtc cac gta tgg atc ctg gcc ggc ctc         48
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu           
1               5                   10                  15                

tgg ctg gcc gtg gcc ggg cgt cca ctt gct ttt tct gat gct ggt cca         96
Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro           
            20                  25                  30                    

cac gtt cac tac ggc tgg ggc gac ccc atc cgc ctg cgg cac ctg tac        144
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr           
        35                  40                  45                        

acc tcc ggc ccc cac ggg ctc tcc agc tgc ttc ctg cgc atc cgt gcc        192
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala           
    50                  55                  60                            

gac ggc gtc gtg gac tgc gcg cgg ggc cag agc gcg cac agt ttg ctg        240
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu           
65                  70                  75                  80            

gag atc aag gca gtc gct ctg cgg acc gtg gcc atc aag ggc gtg cac        288
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His           
                85                  90                  95                

agc gtg cgg tac ctc tgc atg ggc gcc gac ggc aag atg cag ggg ctg        336
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu           
            100                 105                 110                   

ctt cag tac tcg gag gaa gac tgt gct ttc gag gag gag atc cgc cca        384
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro           
        115                 120                 125                       

gat ggc tac aat gtg tac cga tcc gag aag cac cgc ctc ccg gtc tcc        432
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser           
    130                 135                 140                           

ctg agc agt gcc aaa cag cgg cag ctg tac aag aac aga ggc ttt ctt        480
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu           
145                 150                 155                 160           

cca ctc tct cat ttc ctg ccc atg ctg ccc atg gtc cca gag gag cct        528
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro           
                165                 170                 175               

gag gac ctc agg ggc cac ttg gaa tct gac atg ttc tct tcg ccc ctg        576
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu           
            180                 185                 190                   

gag acc gac agc atg gac cca ttt ggg ctt gtc acc gga ctg gag gcc        624
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala           
        195                 200                 205                       

gtg agg agt ccc agc ttt gag aag                                        648
Val Arg Ser Pro Ser Phe Glu Lys                                           
    210                 215                                               


<210>  10
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  11
<211>  582
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(582)

<400>  11
cgt cca ctt gct ttt tct gat gct ggt cca cac gtt cac tac ggc tgg         48
Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp           
1               5                   10                  15                

ggc gac ccc atc cgc ctg cgg cac ctg tac acc tcc ggc ccc cac ggg         96
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly           
            20                  25                  30                    

ctc tcc agc tgc ttc ctg cgc atc cgt gcc gac ggc gtc gtg gac tgc        144
Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys           
        35                  40                  45                        

gcg cgg ggc cag agc gcg cac agt ttg ctg gag atc aag gca gtc gct        192
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala           
    50                  55                  60                            

ctg cgg acc gtg gcc atc aag ggc gtg cac agc gtg cgg tac ctc tgc        240
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys           
65                  70                  75                  80            

atg ggc gcc gac ggc aag atg cag ggg ctg ctt cag tac tcg gag gaa        288
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu           
                85                  90                  95                

gac tgt gct ttc gag gag gag atc cgc cca gat ggc tac aat gtg tac        336
Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr           
            100                 105                 110                   

cga tcc gag aag cac cgc ctc ccg gtc tcc ctg agc agt gcc aaa cag        384
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln           
        115                 120                 125                       

cgg cag ctg tac aag aac aga ggc ttt ctt cca ctc tct cat ttc ctg        432
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu           
    130                 135                 140                           

ccc atg ctg ccc atg gtc cca gag gag cct gag gac ctc agg ggc cac        480
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His           
145                 150                 155                 160           

ttg gaa tct gac atg ttc tct tcg ccc ctg gag acc gac agc atg gac        528
Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp           
                165                 170                 175               

cca ttt ggg ctt gtc acc gga ctg gag gcc gtg agg agt ccc agc ttt        576
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe           
            180                 185                 190                   

gag aag                                                                582
Glu Lys                                                                   
                                                                          


<210>  12
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  13
<211>  585
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(585)

<400>  13
atg cgt cca ctt gct ttt tct gat gct ggt cca cac gtt cac tac ggc         48
Met Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly           
1               5                   10                  15                

tgg ggc gac ccc atc cgc ctg cgg cac ctg tac acc tcc ggc ccc cac         96
Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His           
            20                  25                  30                    

ggg ctc tcc agc tgc ttc ctg cgc atc cgt gcc gac ggc gtc gtg gac        144
Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp           
        35                  40                  45                        

tgc gcg cgg ggc cag agc gcg cac agt ttg ctg gag atc aag gca gtc        192
Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val           
    50                  55                  60                            

gct ctg cgg acc gtg gcc atc aag ggc gtg cac agc gtg cgg tac ctc        240
Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu           
65                  70                  75                  80            

tgc atg ggc gcc gac ggc aag atg cag ggg ctg ctt cag tac tcg gag        288
Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu           
                85                  90                  95                

gaa gac tgt gct ttc gag gag gag atc cgc cca gat ggc tac aat gtg        336
Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val           
            100                 105                 110                   

tac cga tcc gag aag cac cgc ctc ccg gtc tcc ctg agc agt gcc aaa        384
Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys           
        115                 120                 125                       

cag cgg cag ctg tac aag aac aga ggc ttt ctt cca ctc tct cat ttc        432
Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe           
    130                 135                 140                           

ctg ccc atg ctg ccc atg gtc cca gag gag cct gag gac ctc agg ggc        480
Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly           
145                 150                 155                 160           

cac ttg gaa tct gac atg ttc tct tcg ccc ctg gag acc gac agc atg        528
His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met           
                165                 170                 175               

gac cca ttt ggg ctt gtc acc gga ctg gag gcc gtg agg agt ccc agc        576
Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser           
            180                 185                 190                   

ttt gag aag                                                            585
Phe Glu Lys                                                               
        195                                                               


<210>  14
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly 
1               5                   10                  15      


Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His 
            20                  25                  30          


Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp 
        35                  40                  45              


Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val 
    50                  55                  60                  


Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu 
65                  70                  75                  80  


Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu 
                85                  90                  95      


Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val 
            100                 105                 110         


Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys 
        115                 120                 125             


Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe 
    130                 135                 140                 


Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly 
145                 150                 155                 160 


His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met 
                165                 170                 175     


Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser 
            180                 185                 190         


Phe Glu Lys 
        195 


<210>  15
<211>  627
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(627)

<400>  15
atg gac tcg gac gag acc ggg ttc gag cac tca gga ctg tgg gtt tct         48
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser           
1               5                   10                  15                

gtg ctg gct ggt ctt ctg ctg gga gcc tgc cag gca cat cca att cca         96
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro           
            20                  25                  30                    

gat tct tct cca tta tta caa ttc ggg ggc caa gtc cgg cag cgg tac        144
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr           
        35                  40                  45                        

ctc tac aca gat gat gcc cag cag aca gaa gcc cac ctg gag atc agg        192
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg           
    50                  55                  60                            

gag gat ggg acg gtg ggg ggc gct gct gac cag agc ccc gaa agt ctc        240
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu           
65                  70                  75                  80            

ctg cag ctg aaa gcc ttg aag ccg gga gtt att caa atc ttg gga gtc        288
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val           
                85                  90                  95                

aag aca tcc agg ttc ctg tgc cag cgg cca gat ggg gcc ctg tat gga        336
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly           
            100                 105                 110                   

tcg ctc cac ttt gac cct gag gcc tgc agc ttc cgg gag ctg ctt ctt        384
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu           
        115                 120                 125                       

gag gac gga tac aat gtt tac cag tcc gaa gcc cac ggc ctc ccg ctg        432
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu           
    130                 135                 140                           

cac ctg cca ggg aac aag tcc cca cac cgg gac cct gca ccc cga gga        480
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly           
145                 150                 155                 160           

cca gct cgc ttc ctg cca cta cca ggc ctg ccc ccc gca ccc ccg gag        528
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu           
                165                 170                 175               

cca ccc gga atc ctg gcc ccc cag ccc ccc gat gtg ggc tcc tcg gac        576
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp           
            180                 185                 190                   

cct ctg agc atg gtg gga cct tcc cag ggc cga agc ccc agc tac gct        624
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala           
        195                 200                 205                       

tcc                                                                    627
Ser                                                                       
                                                                          


<210>  16
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  17
<211>  543
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(543)

<400>  17
cac ccc atc cct gac tcc agt cct ctc ctg caa ttc ggg ggc caa gtc         48
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val           
1               5                   10                  15                

cgg cag cgg tac ctc tac aca gat gat gcc cag cag aca gaa gcc cac         96
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His           
            20                  25                  30                    

ctg gag atc agg gag gat ggg acg gtg ggg ggc gct gct gac cag agc        144
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser           
        35                  40                  45                        

ccc gaa agt ctc ctg cag ctg aaa gcc ttg aag ccg gga gtt att caa        192
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln           
    50                  55                  60                            

atc ttg gga gtc aag aca tcc agg ttc ctg tgc cag cgg cca gat ggg        240
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly           
65                  70                  75                  80            

gcc ctg tat gga tcg ctc cac ttt gac cct gag gcc tgc agc ttc cgg        288
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg           
                85                  90                  95                

gag ctg ctt ctt gag gac gga tac aat gtt tac cag tcc gaa gcc cac        336
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His           
            100                 105                 110                   

ggc ctc ccg ctg cac ctg cca ggg aac aag tcc cca cac cgg gac cct        384
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro           
        115                 120                 125                       

gca ccc cga gga cca gct cgc ttc ctg cca cta cca ggc ctg ccc ccc        432
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro           
    130                 135                 140                           

gca ccc ccg gag cca ccc gga atc ctg gcc ccc cag ccc ccc gat gtg        480
Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val           
145                 150                 155                 160           

ggc tcc tcg gac cct ctg agc atg gtg gga cct tcc cag ggc cga agc        528
Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser           
                165                 170                 175               

ccc agc tac gct tcc                                                    543
Pro Ser Tyr Ala Ser                                                       
            180                                                           


<210>  18
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  18

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  19
<211>  546
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(546)

<400>  19
atg cac ccc atc cct gac tcc agt cct ctc ctg caa ttc ggg ggc caa         48
Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln           
1               5                   10                  15                

gtc cgg cag cgg tac ctc tac aca gat gat gcc cag cag aca gaa gcc         96
Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala           
            20                  25                  30                    

cac ctg gag atc agg gag gat ggg acg gtg ggg ggc gct gct gac cag        144
His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln           
        35                  40                  45                        

agc ccc gaa agt ctc ctg cag ctg aaa gcc ttg aag ccg gga gtt att        192
Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile           
    50                  55                  60                            

caa atc ttg gga gtc aag aca tcc agg ttc ctg tgc cag cgg cca gat        240
Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp           
65                  70                  75                  80            

ggg gcc ctg tat gga tcg ctc cac ttt gac cct gag gcc tgc agc ttc        288
Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe           
                85                  90                  95                

cgg gag ctg ctt ctt gag gac gga tac aat gtt tac cag tcc gaa gcc        336
Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala           
            100                 105                 110                   

cac ggc ctc ccg ctg cac ctg cca ggg aac aag tcc cca cac cgg gac        384
His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp           
        115                 120                 125                       

cct gca ccc cga gga cca gct cgc ttc ctg cca cta cca ggc ctg ccc        432
Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro           
    130                 135                 140                           

ccc gca ccc ccg gag cca ccc gga atc ctg gcc ccc cag ccc ccc gat        480
Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp           
145                 150                 155                 160           

gtg ggc tcc tcg gac cct ctg agc atg gtg gga cct tcc cag ggc cga        528
Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg           
                165                 170                 175               

agc ccc agc tac gct tcc                                                546
Ser Pro Ser Tyr Ala Ser                                                   
            180                                                           


<210>  20
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  20

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  21
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile 
            20  


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Gly Pro His Gly Leu Ser Ser 
1               5               


<210>  23
<211>  570
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(570)

<400>  23
atg cat cca att cca gat tct tct cca tta tta caa ttc ggg ggc caa         48
Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln           
1               5                   10                  15                

gtc cgc ctg cgg cac ctg tac acc gat gat gcc cag cag aca gaa tgc         96
Val Arg Leu Arg His Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Cys           
            20                  25                  30                    

ttc ctg cgc atc cgt gcc gac ggc gtc gtg gac tgc gcg cgg ggc cag        144
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln           
        35                  40                  45                        

agc gcg cac agt ttg ctg gag atc aag gca gtc gct ctg cgg acc gtg        192
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val           
    50                  55                  60                            

gcc atc aag ggc gtg cac agc gtg cgg tac ctc tgc atg ggc gcc gac        240
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp           
65                  70                  75                  80            

ggc aag atg cag ggg ctg ctt cag tac tcg gag gaa gac tgt gct ttc        288
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe           
                85                  90                  95                

gag gag gag atc cgc cca gat ggc tac aat gtg tac cga tcc gag aag        336
Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys           
            100                 105                 110                   

cac cgc ctc ccg gtc tcc ctg agc agt gcc aaa cag cgg cag ctg tac        384
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr           
        115                 120                 125                       

aag aac aga ggc ttt ctt cca ctc tct cat ttc ctg ccc atg ctg ccc        432
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro           
    130                 135                 140                           

atg gtc cca gag gag cct gag gac ctc agg ggc cac ttg gaa tct gac        480
Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp           
145                 150                 155                 160           

atg ttc tct tcg ccc ctg gag acc gac agc atg gac cca ttt ggg ctt        528
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu           
                165                 170                 175               

gtc acc gga ctg gag gcc gtg agg agt ccc agc ttt gag aag                570
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys                   
            180                 185                 190                   


<210>  24
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  24

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Leu Arg His Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 
                165                 170                 175     


Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            180                 185                 190 


