                         SEQUENCE LISTING

<110>  NVIP Pty Ltd
 
<120>  Therapeutic Canine Immunoglobulins and Methods of Using the Same

<130>  P122572.WO.01

<150>  GB1114858.2
<151>  2011-08-29

<150>  US61/483481
<151>  2011-05-06

<150>  US61/531439
<151>  2011-09-06

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH canine IgG-A heavy chain (caN-HCA)

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val 
        195                 200                 205             


His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys 
    210                 215                 220                 


Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile 
                245                 250                 255     


Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His 
        275                 280                 285             


Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser 
        355                 360                 365             


Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala 
            420                 425                 430         


Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  2
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH canine IgG-B heavy chain (caN-HCB)

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu 
    210                 215                 220                 


Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp 
        275                 280                 285             


Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His 
            340                 345                 350         


Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys 
        355                 360                 365             


Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp 
    370                 375                 380                 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
            420                 425                 430         


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Glu Ser Leu Ser His Ser Pro Gly Lys 
    450                 455         


<210>  3
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH canine IgG-C heavy chain (caN-HCC)

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu Cys 
    210                 215                 220                 


Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile 
                245                 250                 255     


Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys 
        275                 280                 285             


Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln Pro 
            340                 345                 350         


Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn Thr 
        355                 360                 365             


Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  4
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH canine IgG-D heavy chain (caN-HCD)

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val 
        195                 200                 205             


His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu Ser 
    210                 215                 220                 


Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile 
                245                 250                 255     


Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr 
385                 390                 395                 400 


Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  5
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VL canine kappa light chain (caN-kLC)

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  6
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH Aglycosyl canine immunoglobulin heavy chain
       type B (caN-HCB*)

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu 
    210                 215                 220                 


Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp 
        275                 280                 285             


Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His 
            340                 345                 350         


Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys 
        355                 360                 365             


Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp 
    370                 375                 380                 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
            420                 425                 430         


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Glu Ser Leu Ser His Ser Pro Gly Lys 
    450                 455         


<210>  7
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised anti-NGF VH aglycosyl canine immunoglobulin heavy chain
       type C (caN-HCC*)

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Leu Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu Cys 
    210                 215                 220                 


Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile 
                245                 250                 255     


Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys 
        275                 280                 285             


Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln Pro 
            340                 345                 350         


Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn Thr 
        355                 360                 365             


Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  8
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canine immunoglobulin heavy chain type A Fc domain (HCA)

<400>  8

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln 
                165                 170                 175     


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala 
    210                 215                 220                 


His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  9
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canine immunoglobulin heavy chain type B Fc domain (HCB)

<400>  9

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  10
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canine immunoglobulin heavy chain type C Fc domain (HCC)

<400>  10

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Gln Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Ile Pro Glu Pro Val Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro 
            100                 105                 110         


Cys Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser 
145                 150                 155                 160 


Trp Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg 
                165                 170                 175     


Glu Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
            180                 185                 190         


Gly His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn 
        195                 200                 205             


Asn Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro 
    210                 215                 220                 


Gly Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp 
225                 230                 235                 240 


Glu Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe 
                245                 250                 255     


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
            260                 265                 270         


Pro Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
        275                 280                 285             


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 


His Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
                325                 330             


<210>  11
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canine immunoglobulin heavy chain type D Fc domain (HCD)

<400>  11

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln 
                165                 170                 175     


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
    210                 215                 220                 


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  12
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aglycosyl canine immunoglobulin heavy chain type A Fc domain 
       (HCA*)

<400>  12

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln 
                165                 170                 175     


Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala 
    210                 215                 220                 


His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  13
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aglycosyl caninised immunoglobulin heavy chain type B Fc domain 
       (HCB*)

<400>  13

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  14
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aglycosyl canine immunoglobulin heavy chain type C Fc domain 
       (HCC*)

<400>  14

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Gln Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Ile Pro Glu Pro Val Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro 
            100                 105                 110         


Cys Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser 
145                 150                 155                 160 


Trp Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg 
                165                 170                 175     


Glu Glu Gln Ser Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
            180                 185                 190         


Gly His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn 
        195                 200                 205             


Asn Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro 
    210                 215                 220                 


Gly Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp 
225                 230                 235                 240 


Glu Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe 
                245                 250                 255     


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
            260                 265                 270         


Pro Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
        275                 280                 285             


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 


His Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
                325                 330             


<210>  15
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canine immunoglobulin heavy chain type D Fc domain (HCD*)

<400>  15

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln 
                165                 170                 175     


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
    210                 215                 220                 


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


