                         SEQUENCE LISTING

<110>  New Vectys
       Fundacio Privata Centre de Regulacio Genomica
       The University Court of the University of Edinburgh
 
<120>  Genetically modified pig as a cancer prone model

<130>  B1179PC

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  1161
<212>  DNA
<213>  Sus scrofa

<400>  1
atggaggagt cgcagtccga gctgggcgtg gagccccctc tgagtcagga gacattttca       60

gacttgtgga aactgcttcc tgaaaacaac ctgctgtcct ctgagctctc cctggcagca      120

gtgaacgatc tgctgctgtc cccagtcacg aactggctgg atgaaaatcc agatgacgcc      180

tccagagtgc cagcgcctcc tgcagcaaca gcgcccgcac cagctgcccc cgcaccagcc      240

acctcctggc ccctgtcgtc ctttgtccct tctcagaaga cctaccctgg cagctatgat      300

ttccgtctag ggttcctgca ttctggaaca gccaagtctg taacctgcac gtactcccct      360

gccctcaata agctgttttg ccagctggcc aagacctgcc cggtgcagct gtgggtcagc      420

tcgccacccc cgcctggcac ccgtgtccgc gccatggcca tctacaagaa gtcagagtac      480

atgaccgagg tggtgaggcg ctgtccccac catgagcgca gctctgacta tagcgatggt      540

ctggcccctc cccagcatct catccgggtg gaagggaatt tacgggccga gtacttggat      600

gacagaaaca cttttcgaca cagcgttgtg gtgccctacg agccgcccga ggtcggctct      660

gactgtacca ccatccacta caacttcatg tgtaacagct cctgcatggg gggcatgaac      720

cggcggccca tcctcaccat catcacactg gaagatgcca gtggcaactt gctgggacgg      780

aacagctttg aggtgcgtgt ttgtgcctgt cctgggagag accgccgcac agaggaagaa      840

aatttcctca agaagggcca atcttgcccc gagcctcccc ctggcagcac taagcgagca      900

ctgcccacca gcaccagctc ctcgccagtg caaaagaaga agccactgga tggcgagtat      960

ttcaccctcc agatccgtgg gcgtgaacgc ttcgagatgt tccgagagct gaatgacgcc     1020

ttggagctga aggatgccca gactgcgcgg gagtcggggg aaaacagggc ccactccagc     1080

cacctgaagt ctaagaaggg gcagtctccc tcccgccata aaaaaccgat gttcaagaga     1140

gaaggacctg actcagactg a                                               1161


<210>  2
<211>  14120
<212>  DNA
<213>  Sus scrofa

<400>  2
gtccagggcc accatccttg gcgcaggtag ctgctggtct ccggggtcac ctgacgtccc       60

gtctcgagcg tgcatcccag gacagtgaca cgctctcctg agcttcgggt aagctcttaa      120

ctgagcctga tgaatactct atgagtcatg ggctctcggg tctgtgtatt ttcagctcag      180

aagaaaggag gatggaggtg gagcgaaaga tttagtgatt tggggggggg gggggaatgg      240

aagttcttct agcggcatca acagaggaat gcaatgttgg gaggcctgag tgtagatgat      300

agggatgtta ggaccagccg aactaaaaag ctgaacacct gcgccgggta gtggggcttt      360

ggggaaaact tgagcctgcc taaggggttc ttccccacca ccgccaccac cccatttcag      420

tacccggtgt gggggagccc ttaataagac acacaaagca tcaaggtccg aggctttggg      480

atcttggaac tttggggatt tatggctcga gattttagtg cgtatggcat cccagtggaa      540

ccctggactc cattccgaag tggttatccg gagtgctccg ggaagtccaa ggtgctaact      600

tccggacctt tgtcctttct tgagtgaact ttccaactgg ccttcagcgc ctcaggatgg      660

agaaagtcca tttaaaggct gtcagttgtg gaaatgggac atgctaaaca agaggtttgc      720

ccgcgaagcc tcggaggagt aacccggccg gagaggcccg ggagccctgt tattgtttgg      780

ctctgcattt acatttctgc cactcgcagg agcatttccg gtttcttttc ttcggaacag      840

cccactattc acccgatgtg agggaagtag aaagagaaaa ggtcttttaa actggttcct      900

attgcttgct gcaaggggct gttaaccccc tctacctttt ttttgtcctt catggactat      960

ttagccaccg cttttgggaa ggaaaaagca tttgttatga tgcaaacctc agtccctccc     1020

cctcttgtga atggtgtgct ccttcctggt tgtctgctaa ccaggcggac gctaccattg     1080

cctggggcgg ttttcttttc tttaaatatc agaaggcaaa ccttgggtat cttcgagaat     1140

gggtacatct gagatttaaa cgataaaaaa gcataacgat ggggttgttt gtttgtggca     1200

gagaaacaat ttcttctgta tccggctttg ggctgagcca tccccatttt cggacgcaga     1260

atgaacgtcg tgaaagcgga aggggcgggg cttggagagg ggcggggacg gagctcccaa     1320

gtgcagccct ccggtcccgg ctagttctcg cctgcgggag gcggcttgac cccgcgcgaa     1380

gtccgtcgaa tgctctcctg gggcatcttc accatttagg gcgcggtcgc ctacctcgca     1440

cctgctgcga atcagactct gtgggcggta cttacgcgct tttttttcta aatcgagagt     1500

agcatttaca ctcacctcct atcaaaatac aagtctcatg cttctttcca gtttatcttt     1560

aaccctccac cttcattttg atttctgtcc tcatggaata gttttgcctg ttggagaact     1620

gctttataaa tggaatcata caggtcgtgc tcgtttgtgt cagacttctt tccttcagca     1680

aaatctttgt aatgcaccca ttttattgca tgtgtcagtg gtgtatcagt atcttgctcc     1740

ttttcattta atgtgttgca ctggatgaat aaaccatcca ttgtttatcc attctcctcg     1800

tggtggcctt ttgagttgtt tcctgtttgg gattagtttt aataaagctg ctcttgacat     1860

tcttgtacag ttctttttgt ggtcatatgt ttttatgttt cttggatata tacttaggag     1920

tagaattact aagtcataga gtagggaata catctatgcg tttttaaatt ttatttaaaa     1980

attctggagt tcccactgtg gcacacaggg ttaaggacct ggtgtctctg cagcagctca     2040

agtggctgtt gtggtgcaag ttccatccac gcctggctca gtgggttaag gatcttaccc     2100

gggaacttcc atgtgccaca ggtgcgacca tacaaaaaaa ttttttaaat aaaagattct     2160

cattattcaa agtagttgta ccattttaca cttccaccag caagatgtat cctgcctcgg     2220

tgtttggttt gtcagtggtt ctaatgtggc atatcactgt ggttttaatt tgcagttctc     2280

tgttaactgt gtttagcaat ttgtgcttaa tggccatttc tgtgtcatat gtcaggaggc     2340

tgttcaagga gttccctttg tggctcaggg taatgaacct gactagtatc catgaggctg     2400

cggattcaat cccggcctca ctcaatgtgt taaggatcca gccctgctgt ggtataggcc     2460

ggaagctgca gctctgattg gacccctaac ctgggaactt ccatgtgccg aaggtgctgc     2520

cctaaaaaga ccaaaaaaaa gagagagaga gaggctattc aagtcttccc cattttaaac     2580

attggtttat ttgctttttg tattattgag ttgatggaat tatttgtgta ttctggatgg     2640

aatatttttt gttgtcggat acatgtgttt tctcctagcc tgttgcttgc ctataagagc     2700

cctaagagta gcagaagatt cttttctctt gttagtttgt tttggcctgt ttaggaaatc     2760

ttaaccccaa gatcatgaag atattctctt atattttctt ctagaacctt tgtggtttta     2820

ggttttacat ttagatctat gagccataag aaattaacaa attagggagt tcctgtcgtg     2880

gctcagtggt tcacgaatcc gactagaaac cacgaggttt cgcgtcctat ccctgccctt     2940

gctcagtggg ttaaggatct ggcgttgctg tgtgagctgt ggtgtggatc acagacacgg     3000

ctcggatccc agttgttgtg gctgtggggt aggccggcgg ctatagctct gattagaccc     3060

ctagcctggg atcctccatg tgccttgggt gcagccctag aaaatacaaa aaaaaaaaaa     3120

aataaagagc attccccaag tcaggttagc attaacacca tacctaatag tgacagactg     3180

aatgcttttt ctctaaggtc aggaactaga aaaggatttg actctcacca cttcagcatt     3240

ataaactgca ggtcttaacc aggcaagaaa aagaaagaat tcccttgcag cgtagcaggt     3300

taaggagcca ttgttactgc agcagctctg gtcacttctg tggcatgagt tcaatccctg     3360

gcccaggaac ttccatgtgc ctcgggtggg gccaaaaaga aaaagacgta ggagttcctg     3420

ttgtggcaca gtggaaacca atccgattag taaccacgag gttgtgggtt tgatccctgg     3480

ccttgctcag tgggttaaga atactatgca ctgagctgtg gtgtaggtaa catactctgc     3540

tcgaatctgg tatttctgtg gccgtaggcc agcggctaca gctctgattc gacccctagc     3600

ctgagaacct ctgtatgctg tgggtgcagc cctaaaaagc aaaaaaacga aagtaaatgt     3660

taacagttgc aaaagaaaac attgctttat tcagatgcta taattgtgta cacaaagtga     3720

ttatagcaag gttacaagtt tgaaaagcaa tatgcggaaa ttttattttt gtagcaacct     3780

tgaatctgaa gtcaaaaaat gaattttaaa aacaattcca ggagttccct ggtggcctga     3840

tgggttaagg acctggcatt gtcactgctg tgactggggt tggatccctg cagggaactt     3900

ttgcaagcca cgggcacagc caaaaaaaaa aaaaaatgct atttacaata gcattgaaaa     3960

acatggtgga gttcccgtcg tgactcagtg gttaacgaat ccgaccagga accatgaggt     4020

tgcgggttca atccctggcc tggctcagtg ggttaagaat ccggcattgc cgtgagctgt     4080

ggtgtaggtc gcagatgtgg ctcagatccc acattgctgt ggctctggca taggccggcg     4140

gctacagctc tgattagacc cctagcctgg gaacctccat atgccacggt agcagtccta     4200

gaaaaggcaa aaagacaaaa aaataaaaat aaaaagtatt taattcagtg ttttaaaaca     4260

accctaccag gcttggaggt cccactgtgg catagtagtt taagaagcca gtgttgccac     4320

agctgtgcca taggtcatag ctgtggctca gattcgatcc ctggccctag atcttccaat     4380

gtcgtgtgtg tgtgtggcca aaaaaaaatt taaaaaagat atatatatat atatatatat     4440

atatatatct cctcacaggc ttgtttgtgg aagttgccaa gctgattcca aaatgaaaca     4500

ataaatagtg cagagttgga ggtcttaaaa cacctgtctt caagattact ataaaattaa     4560

gtggcgtttc tattgtggct cagcagtaaa gaacccagct agtatccatg aggactcggc     4620

ttcaatctct ggccctgcct gatggcttaa ggatctggtg ttgccatgag ctgccctgta     4680

ggttgcagac atggctcaga tctggcgttt ctctgtctgt ggcataggcg ggctgtgact     4740

ggacccctag cctgggaact tccttccata tgcagcaagt gtggctgtga aaaaagaaaa     4800

acaaacaaaa aacagtctga tggcatttca actgatatac atttggcctc acaaagcttt     4860

gtgtggttgt ggagagtggc taggggtata gatgagacaa taacgcagaa tgttgattat     4920

tcttgaagct tagatgtggg taaatggggg gacattattc tgtttacttt tttatgaggt     4980

taaaattttc cataatgttt gtttatcttt cttttttaga tgtttttatt ttggaaaaat     5040

gcagacagat acaagagtaa caacatattt ccccaccaaa attttttctt ttttgtcttt     5100

ttgtcttttt gccatttctt ggaccgcttc cacggcacat ggaggttccc aggctagggg     5160

tctaatcaga gctgtagccg ccagcctaca ccagagccac agcaacacgg gatccaagcc     5220

gcatctgcaa cccataccac agctcacagc aacatcggat ccccaaccca ctgagcaagg     5280

ccagggatcg aacccgaaac ctcatggttc ccaggcggat tcgttaacca ctgagccatg     5340

atgggaactc caccaccaaa taattttaac acttaatatt ttgtccatat tttaatgtat     5400

ggattttttt tttttttttt tttttgccac acccacagca tgcagaagtt cccaagccag     5460

gaattgaact ctcgccacag cagtgacaac gccagatcct taaccagtag gccaccaggg     5520

aacttctgga tgccgtcttt ttaaattttt ctttgttaat aaagttaaaa ctccctttga     5580

ctatactcct agtatcataa gcacacatcc ctcctctccc tgagaacgtc actatcatgg     5640

attttgtgaa tttttattct tcttgcctat ctttataatt tcacgtgcat atgtgtataa     5700

gcaatagtca ttgtatattt tttgatttca caattaaatt aaaatgactg tgttttgctt     5760

tttttcttgc aaattatctt ttcaccccat gtgtttctga gctgtatctg gttccacata     5820

cagataattc acttccctaa accactgcag taaatttctc ctgtgagtga acacaccgtg     5880

tttcctttat ctcctcccta ctgatataag gttgtttctt gtcacctgcc atcaggaaca     5940

acgatgacat gaacattttg gggcaaggct cctgctcctg ccgcctgcaa ccatttttcc     6000

agggagtcca tctaaaagtg gttttgctaa gtagtaagat gtatgtgttt tcagttttac     6060

cagaggctgc cttgtttctt cccagaatca attgtttttt cccctatcac atggctttca     6120

gccagatgtt tttttccatc agacttctgg gtgaagccag gggagccgtt atttagagct     6180

tgggtgtggg agttccctgg tggcccagca gttaaaggac ctggccgttg tcactgctgt     6240

gacgcagctt cgatccccgg cccgggaact tctgcatgcc acaggtgagg gcaaaaataa     6300

aaatgaaacg tagggcttgg ctgtggcctc ggatagccca ggttcatatt cctgcctctg     6360

ccccttggga gctttctggg cctgagtaat tcctttaacc tcagttccct cctctgatga     6420

tacagcacct gcctcactgg ctttttgaga ggattaatga gataagccag cgaaagctgt     6480

gggtccagat agggtctgtt ttcgcagcag ccttgttgtt ctgataatgg gcaggcctgc     6540

cctgcctttg agtctcagcc gagtttattg ccttcccacc tggctgccgc cccgatcagc     6600

ttagccggag agtctggttc ctcttctgac agtttaagat catgaccccc tgatgttcag     6660

acccatggaa agcacctact ctgaagaggt ttcctagaga aaagaacatt gaaaatttag     6720

ttgctaccag ccactgaggg agagacacct cctatgtcca tggggctgtc tccccctcag     6780

tgggcctgag accctgaccc accatccccc gacagcccac atacccacgg gtttattgaa     6840

cacggggttg cgggaaagaa gtgagctagc acagatgtgg gcagaaccac aaaaacccca     6900

cccccctgca atcacagagc tctcgctctc aataatagag aaccaggagt tcccactgtg     6960

gttcagcagt aacgaacccg aatgggctcc atgaggacgc aggttcgatc cctggcctca     7020

ctcagtgggt taaggatccg gtgtcgccat gagctgagct gtggtgtagg ttgcagacat     7080

ggctcggatc ccgagttact gtggctgtat cgtaggctgg cggctctagc tctcattcag     7140

cccctagcct gggaacttcc atatgccaca ggtatggccc taaaaacgta tatatatatc     7200

tggccctttt ctcaacgcta catttccctt aataactgga gtactatctt agagctgagg     7260

acacttaagg gacagagacg ttaagcaacc gcccaaagtt acacagctat tccatggtga     7320

gcttgggatg caggcctagc gcatctgcct ctagagcccg tgctctgcca tctttgccct     7380

gggagctttg atgagtgaaa tcatgcagtg aatttaagtg atgatacaac atcaaaccca     7440

gggcttccga cttctaagcc ccatctctgt ttacacaagc ctcccttcca taaaaacctc     7500

aaagttattt ttatcctcaa tttagagagg gggaccctgg tccttccccc caaggcaaat     7560

atttagagtc ccactgctgt cccctcttgc cttccttcgt gcacgttcat ggcctgtccc     7620

ctgtcatcat tgggagctat ataagtggcc ctttgccggc ctctgacttt catcagctaa     7680

aatctgcacc tctagacgta actgatgaca aaagttacgt tatgcaaagt catcttaatc     7740

cttaatccta ggcattcaaa tggtcagttt tttgtaaaag ctccttcact aacctgtgca     7800

ttgcaggctg ctcccttaac ctctctgaga ctgtcaagaa tcaggtgtgc ttagcgagac     7860

agacaaccca tgtagaaagg gtttgcacac tctaaataaa gcagaaagca ggccctaggt     7920

caacataaag gagcgagtga atattagagg agattagaaa acagctgctt gttggagttc     7980

ctgtcgtggc acagcggaaa caaatccaat taagaaccat gaggttgcag gttcgatccc     8040

tggcctcgct ccgtgggtta aggatcgggc attgctctga gctgtggtgt acgtcgcaga     8100

tgtggctcgg atctggtgtg gctgtggctg tggtgtaggc cgacagctgt acctccgatt     8160

ggacccctag cctgggaacc tccatatgcc gtgggtgcag ccattttaaa aaaaaaaaaa     8220

aaaaaaaaaa agctgcttgc tgcgggtggg gcggtgggga ggtgttttca gtgccattac     8280

attaacacag aaggagaaga gtaatggcag ggatttttgc agcgagcata attctgagca     8340

aagctgatga cagatttggc ttcgagaaag atggcatgat gaaaccattt gaaagctgag     8400

ctgggagatg agatgataga ggcatagcct agtgcggggc cctggcccag accacacagc     8460

tacccctcgg tcctccctcg tacccttgac caatgataac cagctcacag cctgggcaca     8520

acaattcatt cagtcaccac ggtgactgag ccccgagcag gtgcagggca gtatgctaat     8580

agctggcgaa ggagatgctt ccctgccctg aggaagttta tatcccagca gcacacacag     8640

agcgagcgag aaaggtcagc aggtagtgta agcacgagga gcactaacaa cagggtgacc     8700

tgaattcgaa taaggtgaca gagtttggct ggctgtcctt gatcgatcga gcggtctggg     8760

tccctgctga ggtgtgaccc tcaggatggg gtcccagtga gaaggagctt gcccttcagt     8820

gatggcagga ccactgttcc caggagtgaa atgaaccagc gaaggtccgc cgtgcaggga     8880

agggcagcca ctgccgctcg agcatcggga agggagaggg tgctagaaga tgagatcaga     8940

gaggtgggca ggggctgggt ggtgaggaat ttgtatgcca aggtgggggg ggccggcccc     9000

aagggagcag gggggaacgt gggggggcca gggaggcatc tccccctgcc ccgccctgac     9060

cgcggtggag ggacagggct gagttacttc atcctgattc ccacagagga gggcagacat     9120

gggtacacgt ggcggaaggc ttgtggattc agtggtggaa gggtggacaa tccctctctg     9180

gttatctttt ccccgcgggg atgtgcgtgg tgaggggtgg ggcaggtgca gcctggcatg     9240

tgaagggcag ggcgctgccc cagcagcaga gcctcaccac gggtgagtgt ggacggaggg     9300

ggtccctctt ccctcggggc ttgggtgtgt ctcaggctgg atcctggcct ttctccccac     9360

agcggccaca ctcccctcca gggagctgca atggaggagt cgcagtccga gctgggcgtg     9420

gagccccctc tgagtcagga gacattttca gacttgtgga aactgtgagt ggagtctcaa     9480

gggagggctg cccgtcttct aataaccttg cttccccccc caccagcccc cagcccccaa     9540

ccccagtaga ggcctctggg aagcacagac ctatactgac tctctgccct tgtcttccag     9600

gcttcctgaa aacaacctgc tggtaaggac tggggcgcgg caagggcagg ggcctggggg     9660

gctggggggc tggcctcctg actcctgttg ttcccatcca tccgcagtcc tctgagctct     9720

ccctggcagc agtgaacgat ctgctgctgt ccccagtcac gaactggctg gatgaaaatc     9780

cagatgacgc ctccagagtg ccagcgcctc ctgcagcaac agcgcccgca ccagctgccc     9840

ccgcaccagc cacctcctgg cccctgtcgt cctttgtccc ttctcagaag acctaccctg     9900

gcagctatga tttccgtcta gggttcctgc attctggaac agccaagtct gtaacctgca     9960

cggtcagtgg ccttgaggga ctggcttcgt agggacagtg cctggcccct atccccccgg    10020

gtttttctgt ttagaacttc gtggttccac tgcagccttt ggctttgtgt caggctttct    10080

atgtttaacc tatttggtct atgaccttgg accctggtcc caaagttgaa tactcccact    10140

tgaccttggc ctctcatcct tcccatcaca ctcttcagca tttgtcatga ggccatggaa    10200

ctttttttct tttctctcca ctcattcatt ccttggcttt tgtaaggaag cttctgggag    10260

ggagcccccg accctgccat ctctggctac cctccccacc gagcacttgg ctgctaatca    10320

gtatttaggc agcgtctgtt catttgactg ctggctccct gtcctctgac cttctgttcg    10380

ctctccatcc tccctttcct gcagtactcc cctgccctca ataagctgtt ttgccagctg    10440

gccaagacct gcccggtgca gctgtgggtc agctcgccac ccccgcctgg cacccgtgtc    10500

cgcgccatgg ccatctacaa gaagtcagag tacatgaccg aggtggtgag gcgctgtccc    10560

caccatgagc gcagctctga ctatagcgat ggtgagtggg cgggggctgt gggtgggaca    10620

gggctggtgc cgggagctgc caaacccctc attcccaccc ccaccccccg attgctctca    10680

ggtctggccc ctccccagca tctcatccgg gtggaaggga atttacgggc cgagtacttg    10740

gatgacagaa acacttttcg acacagcgtt gtggtgccct acgagccgcc cgaggtctgg    10800

tttggcccct ggggtctccg ggaggagggg gccagagggg tttgtccgtg gccttcctgg    10860

tgggagatga gggcggcttt ctccttctca cttgacctgc cgcagcctcg tgaggcgggt    10920

agagcagatg ggttaccccc attccacagc tgaggcgccc agaggccagt ggcctgccgg    10980

ggctagtagg gtcaccttgg gcctgtgtcg tcccccaggt cggctctgac tgtaccacca    11040

tccactacaa cttcatgtgt aacagctcct gcatgggggg catgaaccgg cggcccatcc    11100

tcaccatcat cacactggaa gatgccaggt aggggccgca cgccgccctc cacgctggcg    11160

ggcccctcct cagcctctgc cagtctccat ggccctgccg ctcatcccct tctcccgggc    11220

ttccagccat ccttccctct ggctgcagcc actttgcgtc cctctgctgc tccctcccag    11280

tgcccttttc cccggctttg gcacccctct tacctgtggc ttcttgatca gctggagctg    11340

aggctcctcg taggatgcgg gggatgggga gggggtgggg ccccgctcac agagcaggga    11400

ggccgggctg gctttcctca ctgcctcctg cttccccccg gggtagtggc aacttgctgg    11460

gacggaacag ctttgaggtg cgtgtttgtg cctgtcctgg gagagaccgc cgcacagagg    11520

aagaaaattt cctcaagaag ggccaatctt gccccgagcc tccccctggc agcactaagc    11580

gaggtaagca ggcaggacca ggaggggtag aggggacagg gagggggcgg ttctgcccaa    11640

aatgcactct tttctcacct ttcctcacct ctttcccagc actgcccacc agcaccagct    11700

cctcgccagt gcaaaagaag aagccactgg atggcgagta tttcaccctc caggtatcga    11760

gtctgggaga gagaggggcc gtttcctgct cttactcagt ggggttggat aaggggagaa    11820

aagctacaaa ggtagcaggt gtgaggttat gcccagtttc tctagccatc cttttgtctg    11880

ttcatcggct tgactcttgt agtgcatatt atctatcggg tttgagagat tgaagtttca    11940

cttgggtcac tccatatgtt aatttcttct tgactgcttt gcctgcattt ggggcatttg    12000

ccaacagggg gcggtagtgc cttgaaacag tggctttatt tatttattta tctttttagg    12060

gctgcaccct ctgcatatgg aggttcccag gctaggggac aaatcggagc tgtagttgcc    12120

ggcctctgcc acagccatag caatgcagga tcggagtctc ttctgcaacc tacaccacag    12180

ttcacggcaa cacaggatcc ttaacccact gagcaaggtc agggatcgaa cccgtgtgct    12240

catggatgct agtccggttc attactgctg agccacggct agaactccct aacataacat    12300

tttaaagaac cctcttccaa aaagaaagtt gttaaagaga gcataaaaat agttcttgtg    12360

agaatttcct tgtgcagcga gttaagaact ggactagtat ccatgaggag tccagttcga    12420

tccctggcct ccctcagtgg taaggatccc aaagctgtgg cgtggctgtg gctgtggtgt    12480

agaccagcgg ctacagctcg aattggaccc ctagcctggg agcttccgta tgccatgaat    12540

gtggccctaa aaaggaaaaa aagtagttct tatgactttg cccaatgctc ctccacccct    12600

tccctgccac agatccgtgg gcgtgaacgc ttcgagatgt tccgagagct gaatgacgcc    12660

ttggagctga aggatgccca gactgcgcgg gagtcggggg aaaacagggc ccactccagg    12720

tgagtgaccc gcgtgccctc ccttgccttc ctgcgttgga aagccgcggg ggtcctctct    12780

aaccctgcgg gtggtaaagg gcagctgagc ccctgctgtc gggtccaaca ttcctccact    12840

ttcttgcctc caggggtcca cacgcctctt gagcccaggg gcatgggatg tttcctttcc    12900

cacttctagc aacccttaga ccctcagagc tggggtctta gatgggggcc tgatagccat    12960

gggagggtca gactcagcac tggggggtca gatcctcagc cctacaaagt actaaggagt    13020

cctgtgtggc cttgttattc gccttctcag gctcagtttc ctcattgtca catgggataa    13080

gggggcaatt tcaaggttaa tacctctagg tgctcagtca gtaggtctgc agttggcagt    13140

gacttttttt tttttttgtc tttttagggc cacaaccacg gcacatggaa gttccgaggc    13200

taggggtgga atcagagttg cagccactgg cctacgcctc aaccacagca atgcaggatc    13260

cgagctgcat ctgcaacctc caccacagtt cacggcaatg ccagatcctt aacccactta    13320

gcgagcccag ggatggaacc catgtcctca tggctactag ctgagccaca gcgggaactc    13380

taagcatttt aacttaaatt ctcctccctc ccgcctcagg ccttgcaaag cccagctcca    13440

ggaagagggg ctcagagcct cccattggga taacatcatc ccctcctctc cccctctctc    13500

ctcacagcca cctgaagtct aagaaggggc agtctccctc ccgccataaa aaaccgatgt    13560

tcaagagaga aggacctgac tcagactgat gcctcctgca tcccatcccc ttttgaagtc    13620

cctggcattt tggggactca ggtgcttaga cctctgcttg gtgcaggtgt gccttagaaa    13680

tgccctggaa ttcctctata tgcttggcct ggggctctgc taaagaaatt ggcctgcact    13740

ggtgggttgc gggggtgggg ggtggggggt ggataagggg tactgggggc cttccggctt    13800

agctttttaa gggtttttgt atttttttta ttaaattttt ttcatttttt taaagtttaa    13860

agtatagttg ctgtttccgt gtgtttttaa agggttttat tggtaaaatg ttcagagagg    13920

taggaaaatg ttcctgcgta tcaggaacag gttaccacca gccatacact gggtcggaag    13980

cccagttctc caccgtaata ggcagaagag tgcctttccc tgataacctc cctccccatg    14040

ctggttggga gaatttatga aataatgtat tgttttcttt ttatatgttt cttattttcc    14100

aataaaatag tgtggtagca                                                14120


<210>  3
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  4
<211>  32
<212>  DNA
<213>  Sus scrofa

<400>  4
ccaccatcca ctacaacttc atgtgcaaca gc                                     32


<210>  5
<211>  322
<212>  PRT
<213>  Artificial

<220>
<223>  z1166R ZFN amino acid sequence

<400>  5

Met Ala Pro Lys Lys Lys Arg Lys Val Ala Glu Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp Thr Leu Ser Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Lys Asp Ala Arg Ile Asn His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Ser His Leu Ser Thr His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Lys Ser 
            100                 105                 110         


Asp Asn Arg Thr Thr His Thr Lys Ile His Gln Asn Lys Lys Gln Leu 
        115                 120                 125             


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
    130                 135                 140                 


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
145                 150                 155                 160 


Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
                165                 170                 175     


Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro 
            180                 185                 190         


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
        195                 200                 205             


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
    210                 215                 220                 


Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys 
225                 230                 235                 240 


His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
                245                 250                 255     


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
            260                 265                 270         


Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val 
        275                 280                 285             


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
    290                 295                 300                 


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
305                 310                 315                 320 


Asn Phe 
        


<210>  6
<211>  322
<212>  PRT
<213>  Sus scrofa

<400>  6

Met Ala Pro Lys Lys Lys Arg Lys Val Ala Glu Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Ser Asn Leu Ile Val 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Gln Asn Ala Asn Arg Asn Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Ser Ala Leu Ser Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Asn Ser 
            100                 105                 110         


Ser Asn Arg Thr Val His Thr Lys Ile His Gln Asn Lys Lys Gln Leu 
        115                 120                 125             


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
    130                 135                 140                 


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
145                 150                 155                 160 


Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
                165                 170                 175     


Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro 
            180                 185                 190         


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
        195                 200                 205             


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
    210                 215                 220                 


Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys 
225                 230                 235                 240 


His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
                245                 250                 255     


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
            260                 265                 270         


Ala Gln Leu Thr Arg Leu Asn His Lys Thr Asn Cys Asn Gly Ala Val 
        275                 280                 285             


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
    290                 295                 300                 


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
305                 310                 315                 320 


Asn Phe 
        


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  z1166R ZFP amino acid sequence

<400>  7

Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp Thr Leu 
1               5                   10                  15      


Ser Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
            20                  25                  30          


Ile Cys Gly Arg Lys Phe Ala Arg Lys Asp Ala Arg Ile Asn His Thr 
        35                  40                  45              


Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met 
    50                  55                  60                  


Arg Asn Phe Ser Arg Ser Ser His Leu Ser Thr His Ile Arg Thr His 
65                  70                  75                  80  


Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala 
                85                  90                  95      


Lys Ser Asp Asn Arg Thr Thr His Thr Lys Ile His 
            100                 105             


<210>  8
<211>  85
<212>  PRT
<213>  Sus scrofa

<400>  8

Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Ser Asn Leu 
1               5                   10                  15      


Ile Val His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
            20                  25                  30          


Ile Cys Gly Arg Lys Phe Ala Gln Asn Ala Asn Arg Asn Thr His Thr 
        35                  40                  45              


Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met 
    50                  55                  60                  


Arg Asn Phe Ser Arg Ser Ser Ala Leu Ser Arg His Ile Arg Thr His 
65                  70                  75                  80  


Thr Gly Glu Lys Pro 
                85  


<210>  9
<211>  11281
<212>  DNA
<213>  Artificial

<220>
<223>  Pt161 (Ptrip-CMV- z1166R -WPRE) nucleotidic sequence (p53 ZFN)

<400>  9
ttgtacaaag tggtgatcgc taccggactc agatccggcc catctgatgg gtcatcgagc       60

tcaagcttcg aattcccgat aatcaacctc tggattacaa aatttgtgaa agattgactg      120

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt      180

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc      240

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt      300

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga      360

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct      420

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga      480

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct      540

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc      600

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg      660

cctccccgca tcgggaattc tgcagtcgac ggtaccttta agaccaatga cttacaaggc      720

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc      780

ccaacgaaga caaaatcgtc gagagatgct gcatataagc agctgctttt tgcttgtact      840

gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca      900

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      960

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc     1020

agtagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca     1080

gagagtgaga ggccttgaca ttataataga tttagcagga attgaactag gagtggagca     1140

cacaggcaaa gctgcagaag tacttggaag aagccaccag agatactcac gattctgcac     1200

atacctggct aatcccagat cctaaggatt acattaagtt tactaacatt tatataatga     1260

tttatagttt aaagtataaa cttatctaat ttactattct gacagatatt aattaatcct     1320

caaatatcat aagagatgat tactattatc cccatttaac acaagaggaa actgagaggg     1380

aaagatgttg aagtaatttt cccacaatta cagcatccgt tagttacgac tctatgatct     1440

tctgacacaa attccattta ctcctcaccc tatgactcag tcgaatatat caaagttatg     1500

gacattatgc taagtaacaa attacccttt tatatagtaa atactgagta gattgagaga     1560

agaaattgtt tgcaaacctg aatagcttca agaagaagag aagtgaggat aagaataaca     1620

gttgtcattt aacaagtttt aacaagtaac ttggttagaa agggattcaa atgcataaag     1680

caagggataa atttttctgg caacaagact atacaatata accttaaata tgacttcaaa     1740

taattgttgg aacttgataa aactaattaa atattattga agattatcaa tattataaat     1800

gtaatttact tttaaaaagg gaacatagaa atgtgtatca ttagagtaga aaacaatcct     1860

tattatcaca atttgtcaaa acaagtttgt tattaacaca agtagaatac tgcattcaat     1920

taagttgact gcagattttg tgttttgtta aaattagaaa gagataacaa caatttgaat     1980

tattgaaagt aacatgtaaa tagttctaca tacgttcttt tgacatcttg ttcaatcatt     2040

gatcgaagtt ctttatcttg gaagaatttg ttccaaagac tctgaaataa ggaaaacaat     2100

ctattatata gtctcacacc tttgttttac ttttagtgat ttcaatttaa taatgtaaat     2160

ggttaaaatt tattcttctc tgagatcatt tcacattgca gatagaaaac ctgagactgg     2220

ggtaattttt attaaaatct aatttaatct cagaaacaca tctttattct aacatcaatt     2280

tttccagttt gatattatca tataaagtca gccttcctca tctgcaggtt ccacaacaaa     2340

aatccaacca actgtggatc aaaaatattg ggaaaaaatt aaaaatagca atacaacaat     2400

aaaaaaatac aaatcagaaa aacagcacag tataacaact ttatttagca tttacaatct     2460

attaggtatt ataagtaatc tagccagatc ctctacgccg gacgcatcgt ggccggcatc     2520

accggcgcca caggtgcggt tgctggcgcc tatatcgccg acatcaccga tggggaagat     2580

cgggctcgcc acttcgggct catgagcgct tgtttcggcg tgggtatggt ggcaggcccc     2640

gtggccgggg gactgttggg cgccatctcc ttgcatgcac cattccttgc ggcggcggtg     2700

ctcaacggcc tcaacctact actgggctgc ttcctaatgc aggagtcgca taagggagag     2760

cgtcgaatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     2820

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     2880

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     2940

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     3000

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     3060

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     3120

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     3180

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     3240

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3300

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     3360

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     3420

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     3480

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     3540

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     3600

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     3660

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     3720

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     3780

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     3840

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     3900

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     3960

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     4020

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     4080

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     4140

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     4200

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     4260

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4320

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     4380

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     4440

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     4500

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     4560

cctacagcgt gagcattgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     4620

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     4680

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     4740

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     4800

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     4860

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     4920

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     4980

cgcgcgttgg ccgattcatt aatgcagctg tggaatgtgt gtcagttagg gtgtggaaag     5040

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     5100

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5160

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     5220

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     5280

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     5340

tgcaaaaagc ttggacacaa gacaggcttg cgagatatgt ttgagaatac cactttatcc     5400

cgcgtcaggg agaggcagtg cgtaaaaaga cgcggactca tgtgaaatac tggtttttag     5460

tgcgccagat ctctataatc tcgcgcaacc tattttcccc tcgaacactt tttaagccgt     5520

agataaacag gctgggacac ttcacatgag cgaaaaatac atcgtcacct gggacatgtt     5580

gcagatccat gcacgtaaac tcgcaagccg actgatgcct tctgaacaat ggaaaggcat     5640

tattgccgta agccgtggcg gtctgtaccg ggtgcgttac tggcgcgtga actgggtatt     5700

cgtcatgtcg ataccgtttg tatttccagc tacgatcacg acaaccagcg cgagcttaaa     5760

gtgctgaaac gcgcagaagg cgatggcgaa ggcttcatcg ttattgatga cctggtggat     5820

accggtggta ctgcggttgc gattcgtgaa atgtatccaa aagcgcactt tgtcaccatc     5880

ttcgcaaaac cggctggtcg tccgctggtt gatgactatg ttgttgatat cccgcaagat     5940

acctggattg aacagccgtg ggatatgggc gtcgtattcg tcccgccaat ctccggtcgc     6000

taatcttttc aacgcctggc actgccgggc gttgttcttt ttaacttcag gcgggttaca     6060

atagtttcca gtaagtattc tggaggctgc atccatgaca caggcaaacc tgagcgaaac     6120

cctgttcaaa ccccgcttta aacatcctga aacctcgacg ctagtccgcc gctttaatca     6180

cggcgcacaa ccgcctgtgc agtcggccct tgatggtaaa accatccctc actggtatcg     6240

catgattaac cgtctgatgt ggatctggcg cggcattgac ccacgcgaaa tcctcgacgt     6300

ccaggcacgt attgtgatga gcgatgccga acgtaccgac gatgatttat acgatacggt     6360

gattggctac cgtggcggca actggattta tgagtgggcc ccggatcttt gtgaaggaac     6420

cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg     6480

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat     6540

tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg     6600

aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc     6660

aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag     6720

aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta     6780

tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg     6840

taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac     6900

acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt     6960

taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata     7020

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     7080

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     7140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     7200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcaactgg     7260

ataactcaag ctaaccaaaa tcatcccaaa cttcccaccc cataccctat taccactgcc     7320

aattacctag tggtttcatt tactctaaac ctgtgattcc tctgaattat tttcatttta     7380

aagaaattgt atttgttaaa tatgtactac aaacttagta gttggaaggg ctaattcact     7440

cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc tacttccctg     7500

attagcagaa ctacacacca gggccagggg tcagatatcc actgaccttt ggatggtgct     7560

acaagctagt accagttgag ccagataagg tagaagaggc caataaagga gagaacacca     7620

gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtgttagagt     7680

ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat ccggagtact     7740

tcaagaactg ctgatatcga gcttgctaca agggactttc cgctggggac tttccaggga     7800

ggcgtggcct gggcgggact ggggagtggc gagccctcag atcctgcata taagcagctg     7860

ctttttgcct gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc     7920

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     7980

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     8040

tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg     8100

agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc     8160

gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg     8220

agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc     8280

cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac     8340

gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac     8400

agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag     8460

caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca     8520

agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc     8580

agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta     8640

gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga     8700

gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc     8760

actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata     8820

gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc     8880

acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag     8940

gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg     9000

ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg     9060

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     9120

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     9180

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     9240

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     9300

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     9360

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     9420

gtgaacggat ctcgacggta tcgccgaatt cacaaatggc agtattcatc cacaatttta     9480

aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa     9540

cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt     9600

attacaggga cagcagagat ccactttggc tgatacgcgg atctacgcgt attaatagta     9660

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     9720

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     9780

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     9840

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     9900

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     9960

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt    10020

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca    10080

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg    10140

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta    10200

tataagcaga gctggtttag tgaaccgtca gatccgatca caagtttgta caaaaaagca    10260

ggctccttaa aactagttgc cgccaccatg gccccaaaga agaagcggaa ggtagctgag    10320

gagaggccgt ttcagtgccg catctgtatg cgcaatttct caaggtcgga taccttgtca    10380

aggcacattc gaacgcatac cggtgagaaa cccttcgcct gtgatatctg tggccgcaag    10440

tttgcaagga aggacgcgcg gatcaaccac accaaaatcc acacagggtc cgagcgcccc    10500

tttcagtgca gaatctgcat gagaaacttt tcgagaagct cacacctctc cacgcacatt    10560

aggacgcaca cgggggagaa accgttcgct tgcgacatct gtggtagaaa gtttgcgaag    10620

tcagacaacc gaacgacaca tactaagatc catcaaaaca aaaagcagct ggtcaagtcg    10680

gagttggaag agaaaaagtc ggagctgcga cataaactta agtacgtccc tcatgaatac    10740

atcgaattga tcgagattgc gcggaacagc actcaagata gaattcttga gatgaaagtg    10800

atggaattct ttatgaaagt atacggatac aggggaaagc acctcggagg ttcgcggaaa    10860

ccggacggag caatctacac ggtagggtcc cccattgact atggggtcat cgtggatacc    10920

aaggcataca gcggtggcta caatcttcct atcgggcagg cggatgagat ggaacgctat    10980

gtggaagaaa atcaaactag aaacaaacac ctcaatccca atgagtggtg gaaagtctat    11040

ccctcatcgg tcactgaatt caagtttctc ttcgtgagcg gacatttcaa agggaactat    11100

aaggcgcagc ttacacgctt gaaccacatt acaaattgca atggagccgt gctgtcggtg    11160

gaggagttgc ttatcggagg ggaaatgatt aaggccggaa cactgacatt ggaggaagtc    11220

cggcggaagt tcaacaatgg cgaaatcaat ttctaaggcg cctcgagccg acccagcttt    11280

c                                                                    11281


<210>  10
<211>  11281
<212>  DNA
<213>  Artificial

<220>
<223>  Pt160 (Ptrip-CMV- z1166L -WPRE) nucleotidic sequence (p53 ZFN)

<400>  10
ttgtacaaag tggtgatcgc taccggactc agatccggcc catctgatgg gtcatcgagc       60

tcaagcttcg aattcccgat aatcaacctc tggattacaa aatttgtgaa agattgactg      120

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt      180

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc      240

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt      300

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga      360

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct      420

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga      480

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct      540

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc      600

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg      660

cctccccgca tcgggaattc tgcagtcgac ggtaccttta agaccaatga cttacaaggc      720

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc      780

ccaacgaaga caaaatcgtc gagagatgct gcatataagc agctgctttt tgcttgtact      840

gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca      900

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      960

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc     1020

agtagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca     1080

gagagtgaga ggccttgaca ttataataga tttagcagga attgaactag gagtggagca     1140

cacaggcaaa gctgcagaag tacttggaag aagccaccag agatactcac gattctgcac     1200

atacctggct aatcccagat cctaaggatt acattaagtt tactaacatt tatataatga     1260

tttatagttt aaagtataaa cttatctaat ttactattct gacagatatt aattaatcct     1320

caaatatcat aagagatgat tactattatc cccatttaac acaagaggaa actgagaggg     1380

aaagatgttg aagtaatttt cccacaatta cagcatccgt tagttacgac tctatgatct     1440

tctgacacaa attccattta ctcctcaccc tatgactcag tcgaatatat caaagttatg     1500

gacattatgc taagtaacaa attacccttt tatatagtaa atactgagta gattgagaga     1560

agaaattgtt tgcaaacctg aatagcttca agaagaagag aagtgaggat aagaataaca     1620

gttgtcattt aacaagtttt aacaagtaac ttggttagaa agggattcaa atgcataaag     1680

caagggataa atttttctgg caacaagact atacaatata accttaaata tgacttcaaa     1740

taattgttgg aacttgataa aactaattaa atattattga agattatcaa tattataaat     1800

gtaatttact tttaaaaagg gaacatagaa atgtgtatca ttagagtaga aaacaatcct     1860

tattatcaca atttgtcaaa acaagtttgt tattaacaca agtagaatac tgcattcaat     1920

taagttgact gcagattttg tgttttgtta aaattagaaa gagataacaa caatttgaat     1980

tattgaaagt aacatgtaaa tagttctaca tacgttcttt tgacatcttg ttcaatcatt     2040

gatcgaagtt ctttatcttg gaagaatttg ttccaaagac tctgaaataa ggaaaacaat     2100

ctattatata gtctcacacc tttgttttac ttttagtgat ttcaatttaa taatgtaaat     2160

ggttaaaatt tattcttctc tgagatcatt tcacattgca gatagaaaac ctgagactgg     2220

ggtaattttt attaaaatct aatttaatct cagaaacaca tctttattct aacatcaatt     2280

tttccagttt gatattatca tataaagtca gccttcctca tctgcaggtt ccacaacaaa     2340

aatccaacca actgtggatc aaaaatattg ggaaaaaatt aaaaatagca atacaacaat     2400

aaaaaaatac aaatcagaaa aacagcacag tataacaact ttatttagca tttacaatct     2460

attaggtatt ataagtaatc tagccagatc ctctacgccg gacgcatcgt ggccggcatc     2520

accggcgcca caggtgcggt tgctggcgcc tatatcgccg acatcaccga tggggaagat     2580

cgggctcgcc acttcgggct catgagcgct tgtttcggcg tgggtatggt ggcaggcccc     2640

gtggccgggg gactgttggg cgccatctcc ttgcatgcac cattccttgc ggcggcggtg     2700

ctcaacggcc tcaacctact actgggctgc ttcctaatgc aggagtcgca taagggagag     2760

cgtcgaatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     2820

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     2880

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     2940

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     3000

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     3060

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     3120

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     3180

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     3240

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3300

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     3360

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     3420

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     3480

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     3540

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     3600

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     3660

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     3720

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     3780

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     3840

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     3900

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     3960

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     4020

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     4080

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     4140

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     4200

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     4260

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4320

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     4380

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     4440

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     4500

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     4560

cctacagcgt gagcattgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     4620

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     4680

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     4740

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     4800

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     4860

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     4920

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     4980

cgcgcgttgg ccgattcatt aatgcagctg tggaatgtgt gtcagttagg gtgtggaaag     5040

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     5100

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5160

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     5220

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     5280

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     5340

tgcaaaaagc ttggacacaa gacaggcttg cgagatatgt ttgagaatac cactttatcc     5400

cgcgtcaggg agaggcagtg cgtaaaaaga cgcggactca tgtgaaatac tggtttttag     5460

tgcgccagat ctctataatc tcgcgcaacc tattttcccc tcgaacactt tttaagccgt     5520

agataaacag gctgggacac ttcacatgag cgaaaaatac atcgtcacct gggacatgtt     5580

gcagatccat gcacgtaaac tcgcaagccg actgatgcct tctgaacaat ggaaaggcat     5640

tattgccgta agccgtggcg gtctgtaccg ggtgcgttac tggcgcgtga actgggtatt     5700

cgtcatgtcg ataccgtttg tatttccagc tacgatcacg acaaccagcg cgagcttaaa     5760

gtgctgaaac gcgcagaagg cgatggcgaa ggcttcatcg ttattgatga cctggtggat     5820

accggtggta ctgcggttgc gattcgtgaa atgtatccaa aagcgcactt tgtcaccatc     5880

ttcgcaaaac cggctggtcg tccgctggtt gatgactatg ttgttgatat cccgcaagat     5940

acctggattg aacagccgtg ggatatgggc gtcgtattcg tcccgccaat ctccggtcgc     6000

taatcttttc aacgcctggc actgccgggc gttgttcttt ttaacttcag gcgggttaca     6060

atagtttcca gtaagtattc tggaggctgc atccatgaca caggcaaacc tgagcgaaac     6120

cctgttcaaa ccccgcttta aacatcctga aacctcgacg ctagtccgcc gctttaatca     6180

cggcgcacaa ccgcctgtgc agtcggccct tgatggtaaa accatccctc actggtatcg     6240

catgattaac cgtctgatgt ggatctggcg cggcattgac ccacgcgaaa tcctcgacgt     6300

ccaggcacgt attgtgatga gcgatgccga acgtaccgac gatgatttat acgatacggt     6360

gattggctac cgtggcggca actggattta tgagtgggcc ccggatcttt gtgaaggaac     6420

cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg     6480

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat     6540

tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg     6600

aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc     6660

aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag     6720

aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta     6780

tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg     6840

taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac     6900

acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt     6960

taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata     7020

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     7080

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     7140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     7200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcaactgg     7260

ataactcaag ctaaccaaaa tcatcccaaa cttcccaccc cataccctat taccactgcc     7320

aattacctag tggtttcatt tactctaaac ctgtgattcc tctgaattat tttcatttta     7380

aagaaattgt atttgttaaa tatgtactac aaacttagta gttggaaggg ctaattcact     7440

cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc tacttccctg     7500

attagcagaa ctacacacca gggccagggg tcagatatcc actgaccttt ggatggtgct     7560

acaagctagt accagttgag ccagataagg tagaagaggc caataaagga gagaacacca     7620

gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtgttagagt     7680

ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat ccggagtact     7740

tcaagaactg ctgatatcga gcttgctaca agggactttc cgctggggac tttccaggga     7800

ggcgtggcct gggcgggact ggggagtggc gagccctcag atcctgcata taagcagctg     7860

ctttttgcct gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc     7920

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     7980

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     8040

tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg     8100

agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc     8160

gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg     8220

agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc     8280

cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac     8340

gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac     8400

agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag     8460

caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca     8520

agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc     8580

agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta     8640

gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga     8700

gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc     8760

actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata     8820

gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc     8880

acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag     8940

gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg     9000

ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg     9060

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     9120

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     9180

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     9240

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     9300

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     9360

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     9420

gtgaacggat ctcgacggta tcgccgaatt cacaaatggc agtattcatc cacaatttta     9480

aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa     9540

cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt     9600

attacaggga cagcagagat ccactttggc tgatacgcgg atctacgcgt attaatagta     9660

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     9720

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     9780

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     9840

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     9900

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     9960

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt    10020

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca    10080

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg    10140

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta    10200

tataagcaga gctggtttag tgaaccgtca gatccgatca caagtttgta caaaaaagca    10260

ggctccttaa aactagttgc cgccaccatg gcccccaaga aaaagcggaa agtcgcagaa    10320

gaaagacctt ttcagtgtag gatctgtatg aggaacttta gccgatcctc gaacctgatc    10380

gtgcatattc ggacacatac tggagagaaa ccgtttgcat gcgacatttg cggaaggaaa    10440

ttcgcgcaaa acgcgaatcg gaatacgcac accaagatcc atacagggtc agagaggccg    10500

tttcagtgtc gaatctgcat gcgcaatttc tcccggagca gcgcgctctc acggcacatc    10560

cggacccata caggcgagaa gccgttcgcg tgtgacattt gtggtcgcaa attcgctaat    10620

tcatcaaatc gcaccgtcca tacgaagatc caccagaaca agaagcagct tgtgaaatcc    10680

gaattggagg agaaaaagtc ggaactccgc cacaagttga agtacgtacc acacgaatac    10740

attgagctga tcgagattgc gagaaattcg acacaagata gaatcttgga gatgaaggta    10800

atggaattct ttatgaaggt ctatggctat agagggaaac acctcggagg atcgagaaag    10860

cccgacgggg ccatctacac tgtcgggtcg ccaatcgact atggagtcat cgtggataca    10920

aaggcctatt cgggaggtta caacctcccc attggacagg cagatgagat gcagcgatat    10980

gtaaaggaga accaaacccg aaacaagcac attaacccca acgagtggtg gaaagtgtac    11040

ccttcatcgg taacggagtt taagtttctg tttgtgtcgg ggcatttcaa aggtaactac    11100

aaggcgcagc ttactagact taaccacaaa acgaactgca acggagcggt gttgtccgtg    11160

gaagagctcc tgatcggggg tgaaatgatc aaggccggca cgcttacgtt ggaagaagtc    11220

aggcgcaaat tcaataacgg ggagatcaat ttctaaggcg cctcgagccg acccagcttt    11280

c                                                                    11281


<210>  11
<211>  11188
<212>  DNA
<213>  Artificial

<220>
<223>  Pt132 (Ptrip-CMV- ZFN3 -WPRE) nucleotidic sequence (GFP ZFN)

<400>  11
ttgtacaaag tggtgattcg agctcaagct tcgaattccc gataatcaac ctctggatta       60

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg      120

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc      180

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca      240

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac      300

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact      360

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc      420

cgtggtgttg tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg      480

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc      540

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac      600

gagtcggatc tccctttggg ccgcctcccc gcatcgggaa ttctgcagtc gacggtacct      660

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg      720

ggactggaag ggctaattca ctcccaacga agacaaaatc gtcgagagat gctgcatata      780

agcagctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc      840

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc      900

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt      960

agtcagtgtg gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat     1020

aacttgcaaa gaaatgaata tcagagagtg agaggccttg acattataat agatttagca     1080

ggaattgaac taggagtgga gcacacaggc aaagctgcag aagtacttgg aagaagccac     1140

cagagatact cacgattctg cacatacctg gctaatccca gatcctaagg attacattaa     1200

gtttactaac atttatataa tgatttatag tttaaagtat aaacttatct aatttactat     1260

tctgacagat attaattaat cctcaaatat cataagagat gattactatt atccccattt     1320

aacacaagag gaaactgaga gggaaagatg ttgaagtaat tttcccacaa ttacagcatc     1380

cgttagttac gactctatga tcttctgaca caaattccat ttactcctca ccctatgact     1440

cagtcgaata tatcaaagtt atggacatta tgctaagtaa caaattaccc ttttatatag     1500

taaatactga gtagattgag agaagaaatt gtttgcaaac ctgaatagct tcaagaagaa     1560

gagaagtgag gataagaata acagttgtca tttaacaagt tttaacaagt aacttggtta     1620

gaaagggatt caaatgcata aagcaaggga taaatttttc tggcaacaag actatacaat     1680

ataaccttaa atatgacttc aaataattgt tggaacttga taaaactaat taaatattat     1740

tgaagattat caatattata aatgtaattt acttttaaaa agggaacata gaaatgtgta     1800

tcattagagt agaaaacaat ccttattatc acaatttgtc aaaacaagtt tgttattaac     1860

acaagtagaa tactgcattc aattaagttg actgcagatt ttgtgttttg ttaaaattag     1920

aaagagataa caacaatttg aattattgaa agtaacatgt aaatagttct acatacgttc     1980

ttttgacatc ttgttcaatc attgatcgaa gttctttatc ttggaagaat ttgttccaaa     2040

gactctgaaa taaggaaaac aatctattat atagtctcac acctttgttt tacttttagt     2100

gatttcaatt taataatgta aatggttaaa atttattctt ctctgagatc atttcacatt     2160

gcagatagaa aacctgagac tggggtaatt tttattaaaa tctaatttaa tctcagaaac     2220

acatctttat tctaacatca atttttccag tttgatatta tcatataaag tcagccttcc     2280

tcatctgcag gttccacaac aaaaatccaa ccaactgtgg atcaaaaata ttgggaaaaa     2340

attaaaaata gcaatacaac aataaaaaaa tacaaatcag aaaaacagca cagtataaca     2400

actttattta gcatttacaa tctattaggt attataagta atctagccag atcctctacg     2460

ccggacgcat cgtggccggc atcaccggcg ccacaggtgc ggttgctggc gcctatatcg     2520

ccgacatcac cgatggggaa gatcgggctc gccacttcgg gctcatgagc gcttgtttcg     2580

gcgtgggtat ggtggcaggc cccgtggccg ggggactgtt gggcgccatc tccttgcatg     2640

caccattcct tgcggcggcg gtgctcaacg gcctcaacct actactgggc tgcttcctaa     2700

tgcaggagtc gcataaggga gagcgtcgaa tggtgcactc tcagtacaat ctgctctgat     2760

gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     2820

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     2880

cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta     2940

tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg     3000

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     3060

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     3120

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     3180

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     3240

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     3300

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     3360

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     3420

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     3480

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     3540

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     3600

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     3660

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     3720

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     3780

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     3840

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     3900

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     3960

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4020

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     4080

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     4140

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     4200

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     4260

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     4320

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     4380

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     4440

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     4500

acgacctaca ccgaactgag atacctacag cgtgagcatt gagaaagcgc cacgcttccc     4560

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     4620

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     4680

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     4740

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     4800

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     4860

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     4920

ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctgtggaatg     4980

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     5040

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     5100

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     5160

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     5220

ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag     5280

gcttttttgg aggcctaggc ttttgcaaaa agcttggaca caagacaggc ttgcgagata     5340

tgtttgagaa taccacttta tcccgcgtca gggagaggca gtgcgtaaaa agacgcggac     5400

tcatgtgaaa tactggtttt tagtgcgcca gatctctata atctcgcgca acctattttc     5460

ccctcgaaca ctttttaagc cgtagataaa caggctggga cacttcacat gagcgaaaaa     5520

tacatcgtca cctgggacat gttgcagatc catgcacgta aactcgcaag ccgactgatg     5580

ccttctgaac aatggaaagg cattattgcc gtaagccgtg gcggtctgta ccgggtgcgt     5640

tactggcgcg tgaactgggt attcgtcatg tcgataccgt ttgtatttcc agctacgatc     5700

acgacaacca gcgcgagctt aaagtgctga aacgcgcaga aggcgatggc gaaggcttca     5760

tcgttattga tgacctggtg gataccggtg gtactgcggt tgcgattcgt gaaatgtatc     5820

caaaagcgca ctttgtcacc atcttcgcaa aaccggctgg tcgtccgctg gttgatgact     5880

atgttgttga tatcccgcaa gatacctgga ttgaacagcc gtgggatatg ggcgtcgtat     5940

tcgtcccgcc aatctccggt cgctaatctt ttcaacgcct ggcactgccg ggcgttgttc     6000

tttttaactt caggcgggtt acaatagttt ccagtaagta ttctggaggc tgcatccatg     6060

acacaggcaa acctgagcga aaccctgttc aaaccccgct ttaaacatcc tgaaacctcg     6120

acgctagtcc gccgctttaa tcacggcgca caaccgcctg tgcagtcggc ccttgatggt     6180

aaaaccatcc ctcactggta tcgcatgatt aaccgtctga tgtggatctg gcgcggcatt     6240

gacccacgcg aaatcctcga cgtccaggca cgtattgtga tgagcgatgc cgaacgtacc     6300

gacgatgatt tatacgatac ggtgattggc taccgtggcg gcaactggat ttatgagtgg     6360

gccccggatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg acaaactacc     6420

tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat gtgttaaact     6480

actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg aatgggagca     6540

gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc catctagtga     6600

tgatgaggct actgctgact ctcaacattc tactcctcca aaaaagaaga gaaaggtaga     6660

agaccccaag gactttcctt cagaattgct aagttttttg agtcatgctg tgtttagtaa     6720

tagaactctt gcttgctttg ctatttacac cacaaaggaa aaagctgcac tgctatacaa     6780

gaaaattatg gaaaaatatt ctgtaacctt tataagtagg cataacagtt ataatcataa     6840

catactgttt tttcttactc cacacaggca tagagtgtct gctattaata actatgctca     6900

aaaattgtgt acctttagct ttttaatttg taaaggggtt aataaggaat atttgatgta     6960

tagtgccttg actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt     7020

taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg     7080

ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7140

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7200

cttatcatgt ctggatcaac tggataactc aagctaacca aaatcatccc aaacttccca     7260

ccccataccc tattaccact gccaattacc tagtggtttc atttactcta aacctgtgat     7320

tcctctgaat tattttcatt ttaaagaaat tgtatttgtt aaatatgtac tacaaactta     7380

gtagttggaa gggctaattc actcccaaag aagacaagat atccttgatc tgtggatcta     7440

ccacacacaa ggctacttcc ctgattagca gaactacaca ccagggccag gggtcagata     7500

tccactgacc tttggatggt gctacaagct agtaccagtt gagccagata aggtagaaga     7560

ggccaataaa ggagagaaca ccagcttgtt acaccctgtg agcctgcatg ggatggatga     7620

cccggagaga gaagtgttag agtggaggtt tgacagccgc ctagcatttc atcacgtggc     7680

ccgagagctg catccggagt acttcaagaa ctgctgatat cgagcttgct acaagggact     7740

ttccgctggg gactttccag ggaggcgtgg cctgggcggg actggggagt ggcgagccct     7800

cagatcctgc atataagcag ctgctttttg cctgtactgg gtctctctgg ttagaccaga     7860

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     7920

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     7980

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggactt     8040

gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg ctgaagcgcg     8100

cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga ctagcggagg     8160

ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa ttagatcgcg     8220

atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa aacatatagt     8280

atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag aaacatcaga     8340

aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat cagaagaact     8400

tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga tagagataaa     8460

agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta agaccaccgc     8520

acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac aattggagaa     8580

gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg     8640

caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct ttgttccttg     8700

ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg acggtacagg     8760

ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg gctattgagg     8820

cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag gcaagaatcc     8880

tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt tgctctggaa     8940

aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa tctctggaac     9000

agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat tacacaagct     9060

taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa caagaattat     9120

tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat tggctgtggt     9180

atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata gtttttgctg     9240

tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt cagacccacc     9300

tcccaacccc gaggggaccc gacaggcccg aaggaataga agaagaaggt ggagagagag     9360

acagagacag atccattcga ttagtgaacg gatctcgacg gtatcgccga attcacaaat     9420

ggcagtattc atccacaatt ttaaaagaaa aggggggatt ggggggtaca gtgcagggga     9480

aagaatagta gacataatag caacagacat acaaactaaa gaattacaaa aacaaattac     9540

aaaaattcaa aattttcggg tttattacag ggacagcaga gatccacttt ggctgatacg     9600

cggatctacg cgtattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     9660

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     9720

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     9780

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat     9840

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     9900

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc     9960

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac    10020

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa    10080

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt    10140

aggcgtgtac ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc    10200

tagcgctacc ggactcagat catcacaagt ttgtacaaaa aagcaggctc cggatcctta    10260

aatgccgcca ccatgcccaa gaagaagcgc aaggtcagcg gtgccgaaag gccctatgcc    10320

tgtccggtgg agtcatgcga cagacgcttt tcgacaaaac aaaaactcga tgtccacatt    10380

cgcatccata ctggacagaa gccctttcag tgccggatct gtatgaggaa cttctcagtg    10440

gcgcacaacc tcacccgcca cattcggaca cacacgggag agaagccgtt cgcgtgcgac    10500

atttgcggac ggaagtttgc gcaacatcct aatctgacaa gacatacgaa aatccatcag    10560

aataagaaac agttggtcaa atccgaactg gaggaaaaga aatccgagtt gcggcacaaa    10620

cttaagtacg tccctcacga atacatcgaa cttatcgaaa tcgcccgaaa ttcgactcaa    10680

gacagaatct tggagatgaa agtgatggaa ttcttcatga aagtgtatgg ttatagaggg    10740

aagcatttgg gagggtcgcg caaaccggat ggtgcaatct acactgtggg ttccccaatt    10800

gactacggag taattgtgga cacgaaggcc tactcaggcg ggtataacct gccgattggg    10860

caggcggatg agatgcagcg gtatgtagaa gagaaccaga cacgaaacaa gcacattaac    10920

cctaacgagt ggtggaaagt gtacccatcg tcggtcaccg aattcaaatt cctgtttgta    10980

agcgggcact ttaagggcaa ttacaaggca caattgacac gactcaatca cattacgaat    11040

tgtaatggag ctgtccttag cgtggaagag ctccttatcg gaggagagat gatcaaagct    11100

ggcaccctga cgctcgaaga agtaaggagg aaattcaata acggggagat caacttttag    11160

tgaggcgcgg atccccgacc cagctttc                                       11188


<210>  12
<211>  11188
<212>  DNA
<213>  Artificial

<220>
<223>  Pt133 (Ptrip-CMV- ZFN4 -WPRE) nucleotidic sequence (GFP ZFN)

<400>  12
ttgtacaaag tggtgattcg agctcaagct tcgaattccc gataatcaac ctctggatta       60

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg      120

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc      180

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca      240

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac      300

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact      360

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc      420

cgtggtgttg tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg      480

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc      540

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac      600

gagtcggatc tccctttggg ccgcctcccc gcatcgggaa ttctgcagtc gacggtacct      660

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg      720

ggactggaag ggctaattca ctcccaacga agacaaaatc gtcgagagat gctgcatata      780

agcagctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc      840

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc      900

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt      960

agtcagtgtg gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat     1020

aacttgcaaa gaaatgaata tcagagagtg agaggccttg acattataat agatttagca     1080

ggaattgaac taggagtgga gcacacaggc aaagctgcag aagtacttgg aagaagccac     1140

cagagatact cacgattctg cacatacctg gctaatccca gatcctaagg attacattaa     1200

gtttactaac atttatataa tgatttatag tttaaagtat aaacttatct aatttactat     1260

tctgacagat attaattaat cctcaaatat cataagagat gattactatt atccccattt     1320

aacacaagag gaaactgaga gggaaagatg ttgaagtaat tttcccacaa ttacagcatc     1380

cgttagttac gactctatga tcttctgaca caaattccat ttactcctca ccctatgact     1440

cagtcgaata tatcaaagtt atggacatta tgctaagtaa caaattaccc ttttatatag     1500

taaatactga gtagattgag agaagaaatt gtttgcaaac ctgaatagct tcaagaagaa     1560

gagaagtgag gataagaata acagttgtca tttaacaagt tttaacaagt aacttggtta     1620

gaaagggatt caaatgcata aagcaaggga taaatttttc tggcaacaag actatacaat     1680

ataaccttaa atatgacttc aaataattgt tggaacttga taaaactaat taaatattat     1740

tgaagattat caatattata aatgtaattt acttttaaaa agggaacata gaaatgtgta     1800

tcattagagt agaaaacaat ccttattatc acaatttgtc aaaacaagtt tgttattaac     1860

acaagtagaa tactgcattc aattaagttg actgcagatt ttgtgttttg ttaaaattag     1920

aaagagataa caacaatttg aattattgaa agtaacatgt aaatagttct acatacgttc     1980

ttttgacatc ttgttcaatc attgatcgaa gttctttatc ttggaagaat ttgttccaaa     2040

gactctgaaa taaggaaaac aatctattat atagtctcac acctttgttt tacttttagt     2100

gatttcaatt taataatgta aatggttaaa atttattctt ctctgagatc atttcacatt     2160

gcagatagaa aacctgagac tggggtaatt tttattaaaa tctaatttaa tctcagaaac     2220

acatctttat tctaacatca atttttccag tttgatatta tcatataaag tcagccttcc     2280

tcatctgcag gttccacaac aaaaatccaa ccaactgtgg atcaaaaata ttgggaaaaa     2340

attaaaaata gcaatacaac aataaaaaaa tacaaatcag aaaaacagca cagtataaca     2400

actttattta gcatttacaa tctattaggt attataagta atctagccag atcctctacg     2460

ccggacgcat cgtggccggc atcaccggcg ccacaggtgc ggttgctggc gcctatatcg     2520

ccgacatcac cgatggggaa gatcgggctc gccacttcgg gctcatgagc gcttgtttcg     2580

gcgtgggtat ggtggcaggc cccgtggccg ggggactgtt gggcgccatc tccttgcatg     2640

caccattcct tgcggcggcg gtgctcaacg gcctcaacct actactgggc tgcttcctaa     2700

tgcaggagtc gcataaggga gagcgtcgaa tggtgcactc tcagtacaat ctgctctgat     2760

gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     2820

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     2880

cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta     2940

tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg     3000

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     3060

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     3120

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     3180

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     3240

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     3300

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     3360

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     3420

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     3480

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     3540

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     3600

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     3660

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     3720

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     3780

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     3840

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     3900

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     3960

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4020

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     4080

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     4140

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     4200

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     4260

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     4320

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     4380

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     4440

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     4500

acgacctaca ccgaactgag atacctacag cgtgagcatt gagaaagcgc cacgcttccc     4560

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     4620

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     4680

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     4740

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     4800

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     4860

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     4920

ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctgtggaatg     4980

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     5040

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     5100

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     5160

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     5220

ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag     5280

gcttttttgg aggcctaggc ttttgcaaaa agcttggaca caagacaggc ttgcgagata     5340

tgtttgagaa taccacttta tcccgcgtca gggagaggca gtgcgtaaaa agacgcggac     5400

tcatgtgaaa tactggtttt tagtgcgcca gatctctata atctcgcgca acctattttc     5460

ccctcgaaca ctttttaagc cgtagataaa caggctggga cacttcacat gagcgaaaaa     5520

tacatcgtca cctgggacat gttgcagatc catgcacgta aactcgcaag ccgactgatg     5580

ccttctgaac aatggaaagg cattattgcc gtaagccgtg gcggtctgta ccgggtgcgt     5640

tactggcgcg tgaactgggt attcgtcatg tcgataccgt ttgtatttcc agctacgatc     5700

acgacaacca gcgcgagctt aaagtgctga aacgcgcaga aggcgatggc gaaggcttca     5760

tcgttattga tgacctggtg gataccggtg gtactgcggt tgcgattcgt gaaatgtatc     5820

caaaagcgca ctttgtcacc atcttcgcaa aaccggctgg tcgtccgctg gttgatgact     5880

atgttgttga tatcccgcaa gatacctgga ttgaacagcc gtgggatatg ggcgtcgtat     5940

tcgtcccgcc aatctccggt cgctaatctt ttcaacgcct ggcactgccg ggcgttgttc     6000

tttttaactt caggcgggtt acaatagttt ccagtaagta ttctggaggc tgcatccatg     6060

acacaggcaa acctgagcga aaccctgttc aaaccccgct ttaaacatcc tgaaacctcg     6120

acgctagtcc gccgctttaa tcacggcgca caaccgcctg tgcagtcggc ccttgatggt     6180

aaaaccatcc ctcactggta tcgcatgatt aaccgtctga tgtggatctg gcgcggcatt     6240

gacccacgcg aaatcctcga cgtccaggca cgtattgtga tgagcgatgc cgaacgtacc     6300

gacgatgatt tatacgatac ggtgattggc taccgtggcg gcaactggat ttatgagtgg     6360

gccccggatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg acaaactacc     6420

tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat gtgttaaact     6480

actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg aatgggagca     6540

gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc catctagtga     6600

tgatgaggct actgctgact ctcaacattc tactcctcca aaaaagaaga gaaaggtaga     6660

agaccccaag gactttcctt cagaattgct aagttttttg agtcatgctg tgtttagtaa     6720

tagaactctt gcttgctttg ctatttacac cacaaaggaa aaagctgcac tgctatacaa     6780

gaaaattatg gaaaaatatt ctgtaacctt tataagtagg cataacagtt ataatcataa     6840

catactgttt tttcttactc cacacaggca tagagtgtct gctattaata actatgctca     6900

aaaattgtgt acctttagct ttttaatttg taaaggggtt aataaggaat atttgatgta     6960

tagtgccttg actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt     7020

taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg     7080

ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7140

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7200

cttatcatgt ctggatcaac tggataactc aagctaacca aaatcatccc aaacttccca     7260

ccccataccc tattaccact gccaattacc tagtggtttc atttactcta aacctgtgat     7320

tcctctgaat tattttcatt ttaaagaaat tgtatttgtt aaatatgtac tacaaactta     7380

gtagttggaa gggctaattc actcccaaag aagacaagat atccttgatc tgtggatcta     7440

ccacacacaa ggctacttcc ctgattagca gaactacaca ccagggccag gggtcagata     7500

tccactgacc tttggatggt gctacaagct agtaccagtt gagccagata aggtagaaga     7560

ggccaataaa ggagagaaca ccagcttgtt acaccctgtg agcctgcatg ggatggatga     7620

cccggagaga gaagtgttag agtggaggtt tgacagccgc ctagcatttc atcacgtggc     7680

ccgagagctg catccggagt acttcaagaa ctgctgatat cgagcttgct acaagggact     7740

ttccgctggg gactttccag ggaggcgtgg cctgggcggg actggggagt ggcgagccct     7800

cagatcctgc atataagcag ctgctttttg cctgtactgg gtctctctgg ttagaccaga     7860

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     7920

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     7980

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggactt     8040

gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg ctgaagcgcg     8100

cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga ctagcggagg     8160

ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa ttagatcgcg     8220

atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa aacatatagt     8280

atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag aaacatcaga     8340

aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat cagaagaact     8400

tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga tagagataaa     8460

agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta agaccaccgc     8520

acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac aattggagaa     8580

gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg     8640

caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct ttgttccttg     8700

ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg acggtacagg     8760

ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg gctattgagg     8820

cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag gcaagaatcc     8880

tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt tgctctggaa     8940

aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa tctctggaac     9000

agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat tacacaagct     9060

taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa caagaattat     9120

tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat tggctgtggt     9180

atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata gtttttgctg     9240

tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt cagacccacc     9300

tcccaacccc gaggggaccc gacaggcccg aaggaataga agaagaaggt ggagagagag     9360

acagagacag atccattcga ttagtgaacg gatctcgacg gtatcgccga attcacaaat     9420

ggcagtattc atccacaatt ttaaaagaaa aggggggatt ggggggtaca gtgcagggga     9480

aagaatagta gacataatag caacagacat acaaactaaa gaattacaaa aacaaattac     9540

aaaaattcaa aattttcggg tttattacag ggacagcaga gatccacttt ggctgatacg     9600

cggatctacg cgtattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     9660

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     9720

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     9780

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat     9840

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     9900

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc     9960

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac    10020

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa    10080

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt    10140

aggcgtgtac ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc    10200

tagcgctacc ggactcagat catcacaagt ttgtacaaaa aagcaggctc cggatcctta    10260

aatgccgcca ccatgcccaa gaagaagcgc aaggtcagcg gtgccgaaag gccctatgcc    10320

tgtccggtgg agtcatgcga cagacgcttt tcagcgcctt cgaaactcga taggcacatt    10380

cgcatccata ctggacagaa gccctttcag tgccggatct gtatgaggaa cttctccgac    10440

cggtcaaacc tcacccgcca cattcggaca cacacgggag agaagccgtt cgcgtgcgac    10500

atttgcggac ggaagtttgc ggaccaagga aatctgatta gacatacgaa aatccatcag    10560

aataagaaac agttggtcaa atccgaactg gaggaaaaga aatccgagtt gcggcacaaa    10620

cttaagtacg tccctcacga atacatcgaa cttatcgaaa tcgcccgaaa ttcgactcaa    10680

gacagaatct tggagatgaa agtgatggaa ttcttcatga aagtgtatgg ttatagaggg    10740

aagcatttgg gagggtcgcg caaaccggat ggtgcaatct acactgtggg ttccccaatt    10800

gactacggag taattgtgga cacgaaggcc tactcaggcg ggtataacct gccgattggg    10860

caggcggatg agatgcagcg gtatgtagaa gagaaccaga cacgaaacaa gcacattaac    10920

cctaacgagt ggtggaaagt gtacccatcg tcggtcaccg aattcaaatt cctgtttgta    10980

agcgggcact ttaagggcaa ttacaaggca caattgacac gactcaatca cattacgaat    11040

tgtaatggag ctgtccttag cgtggaagag ctccttatcg gaggagagat gatcaaagct    11100

ggcaccctga cgctcgaaga agtaaggagg aaattcaata acggggagat caacttttag    11160

tgaggcgcgg atccccgacc cagctttc                                       11188


<210>  13
<211>  12150
<212>  DNA
<213>  Artificial

<220>
<223>  Transcomplementation P125 (p8.91-D64V) plasmid sequence

<400>  13
ttaagacagc agtacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg       60

gggggtacag tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag      120

aattacaaaa acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag      180

atccagtttg gaaaggacca gcaaagctcc tctggaaagg tgaaggggca gtagtaatac      240

aagataatag tgacataaaa gtagtgccaa gaagaaaagc aaagatcatc agggattatg      300

gaaaacagat ggcaggtgat gattgtgtgg caagtagaca ggatgaggat taacacatgg      360

aattctgcaa caactgctgt ttatccattt cagaattggg tgtcgacata gcagaatagg      420

cgttactcga cagaggagag caagaaatgg agccagtaga tcctagacta gagccctgga      480

agcatccagg aagtcagcct aaaactgctt gtaccaattg ctattgtaaa aagtgttgct      540

ttcattgcca agtttgtttc atgacaaaag ccttaggcat ctcctatggc aggaagaagc      600

ggagacagcg acgaagagct catcagaaca gtcagactca tcaagcttct ctatcaaagc      660

agtaagtagt acatgtaatg caacctataa tagtagcaat agtagcatta gtagtagcaa      720

taataatagc aatagttgtg tggtccatag taatcataga atataggaaa atggccgctg      780

atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat      840

aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg      900

cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca      960

ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct     1020

ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg     1080

caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac     1140

ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact     1200

gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg     1260

acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt     1320

gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg     1380

gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata     1440

atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat     1500

agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga     1560

cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt     1620

cgattagtga acggatcctt ggcacttatc tgggacgatc tgcggagcct gtgcctcttc     1680

agctaccacc gcttgagaga cttactcttg attgtaacga ggattgtgga acttctggga     1740

cgcagggggt gggaagccct caaatattgg tggaatctcc tacaatattg gagtcaggag     1800

ctaaagaata gtgctgttag cttgctcaat gccacagcca tagcagtagc tgaggggaca     1860

gatagggtta tagaagtagt acaaggagct tgtagagcta ttcgccacat acctagaaga     1920

ataagacagg gcttggaaag gattttgcta taagctcgag gccgccccgg tgaccttcag     1980

accttggcac tggaggtggc ccggcagaag cgcggcatcg tggatcagtg ctgcaccagc     2040

atctgctctc tctaccaact ggagaactac tgcaactagg cccaccacta ccctgtccac     2100

ccctctgcaa tgaataaaac ctttgaaaga gcactacaag ttgtgtgtac atgcgtgcat     2160

gtgcatatgt ggtgcggggg gaacatgagt ggggctggct ggagtggcga tgataagctg     2220

tcaaacatga gaattaattc ttgaagacga aagggcctcg tgatacgcct atttttatag     2280

gttaatgtca tgataataat ggtttcttag tctagaatta attccgtgta ttctatagtg     2340

tcacctaaat cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa     2400

cgacaatatg tacaagccta attgtgtagc atctggctta ctgaagcaga ccctatcatc     2460

tctctcgtaa actgccgtca gagtcggttt ggttggacga accttctgag tttctggtaa     2520

cgccgtcccg cacccggaaa tggtcagcga accaatcagc agggtcatcg ctagccagat     2580

cctctacgcc ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc     2640

ctatatcgcc gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc     2700

ttgtttcggc gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc     2760

cttgcatgca ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg     2820

cttcctaatg caggagtcgc ataagggaga gcgtcgaatg gtgcactctc agtacaatct     2880

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     2940

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     3000

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     3060

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     3120

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     3180

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     3240

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     3300

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     3360

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     3420

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     3480

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     3540

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     3600

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     3660

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     3720

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     3780

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     3840

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     3900

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     3960

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     4020

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     4080

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     4140

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     4200

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     4260

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     4320

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     4380

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     4440

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     4500

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     4560

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     4620

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     4680

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     4740

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     4800

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     4860

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     4920

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     4980

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     5040

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     5100

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     5160

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     5220

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     5280

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     5340

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     5400

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt     5460

gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag     5520

acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac     5580

ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga     5640

gcgaaaaata catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc     5700

gactgatgcc ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc     5760

gggtgcgtta ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag     5820

ctacgatcac gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga     5880

aggcttcatc gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga     5940

aatgtatcca aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt     6000

tgatgactat gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg     6060

cgtcgtattc gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg     6120

cgttgttctt tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg     6180

catccatgac acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg     6240

aaacctcgac gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc     6300

ttgatggtaa aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc     6360

gcggcattga cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg     6420

aacgtaccga cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt     6480

atgagtgggc cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac     6540

aaactaccta cagagattta aagctctaag gtaaatataa aatttttaac ccggatcttt     6600

gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa     6660

agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt     6720

gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc     6780

tttaatgagg aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact     6840

gctgactctc aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac     6900

tttccttcag aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct     6960

tgctttgcta tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa     7020

aaatattctg taacctttat aagtaggcat aacagttata atcataacat actgtttttt     7080

cttactccac acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc     7140

tttagctttt taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact     7200

agagatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     7260

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgttg ggctgcagga     7320

attaattcga gctcgcccga cattgattat tgactagtta ttaatagtaa tcaattacgg     7380

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     7440

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     7500

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     7560

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     7620

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     7680

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     7740

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     7800

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     7860

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     7920

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata     7980

gaagacaccg ggaccgatcc agcctccgcg gccgggaacg gtgcattgga acgcggattc     8040

cccgtgccaa gagtgacgta agtaccgcct atagagtcta taggcccacc cccttggctt     8100

cttatgcgac ggatcgatcc cgtaataagc ttcgaggtcc gcggccggcc gcgttgacgc     8160

gcacggcaag aggcgagggg cggcgactgg tgagagatgg gtgcgagagc gtcagtatta     8220

agcgggggag aattagatcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa     8280

tataaattaa aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct     8340

ggcctgttag aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt     8400

cagacaggat cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg     8460

catcaaagga tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa     8520

aacaaaagta agaaaaaagc acagcaagca gcagctgaca caggacacag caatcaggtc     8580

agccaaaatt accctatagt gcagaacatc caggggcaaa tggtacatca ggccatatca     8640

cctagaactt taaatgcatg ggtaaaagta gtagaagaga aggctttcag cccagaagtg     8700

atacccatgt tttcagcatt atcagaagga gccaccccac aagatttaaa caccatgcta     8760

aacacagtgg ggggacatca agcagccatg caaatgttaa aagagaccat caatgaggaa     8820

gctgcagaat gggatagagt gcatccagtg catgcagggc ctattgcacc aggccagatg     8880

agagaaccaa ggggaagtga catagcagga actactagta cccttcagga acaaatagga     8940

tggatgacac ataatccacc tatcccagta ggagaaatct ataaaagatg gataatcctg     9000

ggattaaata aaatagtaag aatgtatagc cctaccagca ttctggacat aagacaagga     9060

ccaaaggaac cctttagaga ctatgtagac cgattctata aaactctaag agccgagcaa     9120

gcttcacaag aggtaaaaaa ttggatgaca gaaaccttgt tggtccaaaa tgcgaaccca     9180

gattgtaaga ctattttaaa agcattggga ccaggagcga cactagaaga aatgatgaca     9240

gcatgtcagg gagtgggggg acccggccat aaagcaagag ttttggctga agcaatgagc     9300

caagtaacaa atccagctac cataatgata cagaaaggca attttaggaa ccaaagaaag     9360

actgttaagt gtttcaattg tggcaaagaa gggcacatag ccaaaaattg cagggcccct     9420

aggaaaaagg gctgttggaa atgtggaaag gaaggacacc aaatgaaaga ttgtactgag     9480

agacaggcta attttttagg gaagatctgg ccttcccaca agggaaggcc agggaatttt     9540

cttcagagca gaccagagcc aacagcccca ccagaagaga gcttcaggtt tggggaagag     9600

acaacaactc cctctcagaa gcaggagccg atagacaagg aactgtatcc tttagcttcc     9660

ctcagatcac tctttggcag cgacccctcg tcacaataaa gatagggggg caattaaagg     9720

aagctctatt agatacagga gcagatgata cagtattaga agaaatgaat ttgccaggaa     9780

gatggaaacc aaaaatgata gggggaattg gaggttttat caaagtaaga cagtatgatc     9840

agatactcat agaaatctgc ggacataaag ctataggtac agtattagta ggacctacac     9900

ctgtcaacat aattggaaga aatctgttga ctcagattgg ctgcacttta aattttccca     9960

ttagtcctat tgagactgta ccagtaaaat taaagccagg aatggatggc ccaaaagtta    10020

aacaatggcc attgacagaa gaaaaaataa aagcattagt agaaatttgt acagaaatgg    10080

aaaaggaagg aaaaatttca aaaattgggc ctgaaaatcc atacaatact ccagtatttg    10140

ccataaagaa aaaagacagt actaaatgga gaaaattagt agatttcaga gaacttaata    10200

agagaactca agatttctgg gaagttcaat taggaatacc acatcctgca gggttaaaac    10260

agaaaaaatc agtaacagta ctggatgtgg gcgatgcata tttttcagtt cccttagata    10320

aagacttcag gaagtatact gcatttacca tacctagtat aaacaatgag acaccaggga    10380

ttagatatca gtacaatgtg cttccacagg gatggaaagg atcaccagca atattccagt    10440

gtagcatgac aaaaatctta gagcctttta gaaaacaaaa tccagacata gtcatctatc    10500

aatacatgga tgatttgtat gtaggatctg acttagaaat agggcagcat agaacaaaaa    10560

tagaggaact gagacaacat ctgttgaggt ggggatttac cacaccagac aaaaaacatc    10620

agaaagaacc tccattcctt tggatgggtt atgaactcca tcctgataaa tggacagtac    10680

agcctatagt gctgccagaa aaggacagct ggactgtcaa tgacatacag aaattagtgg    10740

gaaaattgaa ttgggcaagt cagatttatg cagggattaa agtaaggcaa ttatgtaaac    10800

ttcttagggg aaccaaagca ctaacagaag tagtaccact aacagaagaa gcagagctag    10860

aactggcaga aaacagggag attctaaaag aaccggtaca tggagtgtat tatgacccat    10920

caaaagactt aatagcagaa atacagaagc aggggcaagg ccaatggaca tatcaaattt    10980

atcaagagcc atttaaaaat ctgaaaacag gaaagtatgc aagaatgaag ggtgcccaca    11040

ctaatgatgt gaaacaatta acagaggcag tacaaaaaat agccacagaa agcatagtaa    11100

tatggggaaa gactcctaaa tttaaattac ccatacaaaa ggaaacatgg gaagcatggt    11160

ggacagagta ttggcaagcc acctggattc ctgagtggga gtttgtcaat acccctccct    11220

tagtgaagtt atggtaccag ttagagaaag aacccataat aggagcagaa actttctatg    11280

tagatggggc agccaatagg gaaactaaat taggaaaagc aggatatgta actgacagag    11340

gaagacaaaa agttgtcccc ctaacggaca caacaaatca gaagactgag ttacaagcaa    11400

ttcatctagc tttgcaggat tcgggattag aagtaaacat agtgacagac tcacaatatg    11460

cattgggaat cattcaagca caaccagata agagtgaatc agagttagtc agtcaaataa    11520

tagagcagtt aataaaaaag gaaaaagtct acctggcatg ggtaccagca cacaaaggaa    11580

ttggaggaaa tgaacaagta gataaattgg tcagtgctgg aatcaggaaa gtactatttt    11640

tagatggaat agataaggcc caagaagaac atgagaaata tcacagtaat tggagagcaa    11700

tggctagtga ttttaaccta ccacctgtag tagcaaaaga aatagtagcc agctgtgata    11760

aatgtcagct aaaaggggaa gccatgcatg gacaagtaga ctgtagccca ggaatatggc    11820

agctagtttg tacacattta gaaggaaaag ttatcttggt agcagttcat gtagccagtg    11880

gatatataga agcagaagta attccagcag agacagggca agaaacagca tacttcctct    11940

taaaattagc aggaagatgg ccagtaaaaa cagtacatac agacaatggc agcaatttca    12000

ccagtactac agttaaggcc gcctgttggt gggcggggat caagcaggaa tttggcattc    12060

cctacaatcc ccaaagtcaa ggagtaatag aatctatgaa taaagaatta aagaaaatta    12120

taggacaggt aagagatcag gctgaacatc                                     12150


<210>  14
<211>  12150
<212>  DNA
<213>  Artificial

<220>
<223>  Transcomplementation P123 (p8.91-LQ) plasmid sequence

<400>  14
aattctgcaa caactgctgt ttatccattt cagaattggg tgtcgacata gcagaatagg       60

cgttactcga cagaggagag caagaaatgg agccagtaga tcctagacta gagccctgga      120

agcatccagg aagtcagcct aaaactgctt gtaccaattg ctattgtaaa aagtgttgct      180

ttcattgcca agtttgtttc atgacaaaag ccttaggcat ctcctatggc aggaagaagc      240

ggagacagcg acgaagagct catcagaaca gtcagactca tcaagcttct ctatcaaagc      300

agtaagtagt acatgtaatg caacctataa tagtagcaat agtagcatta gtagtagcaa      360

taataatagc aatagttgtg tggtccatag taatcataga atataggaaa atggccgctg      420

atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat      480

aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg      540

cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca      600

ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct      660

ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg      720

caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac      780

ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact      840

gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg      900

acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt      960

gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg     1020

gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata     1080

atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat     1140

agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga     1200

cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt     1260

cgattagtga acggatcctt ggcacttatc tgggacgatc tgcggagcct gtgcctcttc     1320

agctaccacc gcttgagaga cttactcttg attgtaacga ggattgtgga acttctggga     1380

cgcagggggt gggaagccct caaatattgg tggaatctcc tacaatattg gagtcaggag     1440

ctaaagaata gtgctgttag cttgctcaat gccacagcca tagcagtagc tgaggggaca     1500

gatagggtta tagaagtagt acaaggagct tgtagagcta ttcgccacat acctagaaga     1560

ataagacagg gcttggaaag gattttgcta taagctcgag gccgccccgg tgaccttcag     1620

accttggcac tggaggtggc ccggcagaag cgcggcatcg tggatcagtg ctgcaccagc     1680

atctgctctc tctaccaact ggagaactac tgcaactagg cccaccacta ccctgtccac     1740

ccctctgcaa tgaataaaac ctttgaaaga gcactacaag ttgtgtgtac atgcgtgcat     1800

gtgcatatgt ggtgcggggg gaacatgagt ggggctggct ggagtggcga tgataagctg     1860

tcaaacatga gaattaattc ttgaagacga aagggcctcg tgatacgcct atttttatag     1920

gttaatgtca tgataataat ggtttcttag tctagaatta attccgtgta ttctatagtg     1980

tcacctaaat cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa     2040

cgacaatatg tacaagccta attgtgtagc atctggctta ctgaagcaga ccctatcatc     2100

tctctcgtaa actgccgtca gagtcggttt ggttggacga accttctgag tttctggtaa     2160

cgccgtcccg cacccggaaa tggtcagcga accaatcagc agggtcatcg ctagccagat     2220

cctctacgcc ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc     2280

ctatatcgcc gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc     2340

ttgtttcggc gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc     2400

cttgcatgca ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg     2460

cttcctaatg caggagtcgc ataagggaga gcgtcgaatg gtgcactctc agtacaatct     2520

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     2700

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     2760

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     2820

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     2880

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     2940

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     3000

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     3060

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     3120

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     3180

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     3240

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     3300

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     3360

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     3420

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     3480

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     3540

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     3600

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     3660

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     3720

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     3780

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     3840

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     3900

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     3960

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     4020

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     4080

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     4140

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     4200

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     4260

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     4320

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     4380

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     4440

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     4500

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     4560

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     4620

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     4680

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4740

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     4800

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     4860

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     4920

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     4980

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     5040

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt     5100

gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag     5160

acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac     5220

ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga     5280

gcgaaaaata catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc     5340

gactgatgcc ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc     5400

gggtgcgtta ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag     5460

ctacgatcac gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga     5520

aggcttcatc gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga     5580

aatgtatcca aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt     5640

tgatgactat gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg     5700

cgtcgtattc gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg     5760

cgttgttctt tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg     5820

catccatgac acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg     5880

aaacctcgac gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc     5940

ttgatggtaa aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc     6000

gcggcattga cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg     6060

aacgtaccga cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt     6120

atgagtgggc cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac     6180

aaactaccta cagagattta aagctctaag gtaaatataa aatttttaac ccggatcttt     6240

gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa     6300

agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt     6360

gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc     6420

tttaatgagg aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact     6480

gctgactctc aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac     6540

tttccttcag aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct     6600

tgctttgcta tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa     6660

aaatattctg taacctttat aagtaggcat aacagttata atcataacat actgtttttt     6720

cttactccac acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc     6780

tttagctttt taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact     6840

agagatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     6900

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgttg ggctgcagga     6960

attaattcga gctcgcccga cattgattat tgactagtta ttaatagtaa tcaattacgg     7020

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     7080

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     7140

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     7200

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     7260

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     7320

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     7380

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     7440

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     7500

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     7560

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata     7620

gaagacaccg ggaccgatcc agcctccgcg gccgggaacg gtgcattgga acgcggattc     7680

cccgtgccaa gagtgacgta agtaccgcct atagagtcta taggcccacc cccttggctt     7740

cttatgcgac ggatcgatcc cgtaataagc ttcgaggtcc gcggccggcc gcgttgacgc     7800

gcacggcaag aggcgagggg cggcgactgg tgagagatgg gtgcgagagc gtcagtatta     7860

agcgggggag aattagatcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa     7920

tataaattaa aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct     7980

ggcctgttag aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt     8040

cagacaggat cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg     8100

catcaaagga tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa     8160

aacaaaagta agaaaaaagc acagcaagca gcagctgaca caggacacag caatcaggtc     8220

agccaaaatt accctatagt gcagaacatc caggggcaaa tggtacatca ggccatatca     8280

cctagaactt taaatgcatg ggtaaaagta gtagaagaga aggctttcag cccagaagtg     8340

atacccatgt tttcagcatt atcagaagga gccaccccac aagatttaaa caccatgcta     8400

aacacagtgg ggggacatca agcagccatg caaatgttaa aagagaccat caatgaggaa     8460

gctgcagaat gggatagagt gcatccagtg catgcagggc ctattgcacc aggccagatg     8520

agagaaccaa ggggaagtga catagcagga actactagta cccttcagga acaaatagga     8580

tggatgacac ataatccacc tatcccagta ggagaaatct ataaaagatg gataatcctg     8640

ggattaaata aaatagtaag aatgtatagc cctaccagca ttctggacat aagacaagga     8700

ccaaaggaac cctttagaga ctatgtagac cgattctata aaactctaag agccgagcaa     8760

gcttcacaag aggtaaaaaa ttggatgaca gaaaccttgt tggtccaaaa tgcgaaccca     8820

gattgtaaga ctattttaaa agcattggga ccaggagcga cactagaaga aatgatgaca     8880

gcatgtcagg gagtgggggg acccggccat aaagcaagag ttttggctga agcaatgagc     8940

caagtaacaa atccagctac cataatgata cagaaaggca attttaggaa ccaaagaaag     9000

actgttaagt gtttcaattg tggcaaagaa gggcacatag ccaaaaattg cagggcccct     9060

aggaaaaagg gctgttggaa atgtggaaag gaaggacacc aaatgaaaga ttgtactgag     9120

agacaggcta attttttagg gaagatctgg ccttcccaca agggaaggcc agggaatttt     9180

cttcagagca gaccagagcc aacagcccca ccagaagaga gcttcaggtt tggggaagag     9240

acaacaactc cctctcagaa gcaggagccg atagacaagg aactgtatcc tttagcttcc     9300

ctcagatcac tctttggcag cgacccctcg tcacaataaa gatagggggg caattaaagg     9360

aagctctatt agatacagga gcagatgata cagtattaga agaaatgaat ttgccaggaa     9420

gatggaaacc aaaaatgata gggggaattg gaggttttat caaagtaaga cagtatgatc     9480

agatactcat agaaatctgc ggacataaag ctataggtac agtattagta ggacctacac     9540

ctgtcaacat aattggaaga aatctgttga ctcagattgg ctgcacttta aattttccca     9600

ttagtcctat tgagactgta ccagtaaaat taaagccagg aatggatggc ccaaaagtta     9660

aacaatggcc attgacagaa gaaaaaataa aagcattagt agaaatttgt acagaaatgg     9720

aaaaggaagg aaaaatttca aaaattgggc ctgaaaatcc atacaatact ccagtatttg     9780

ccataaagaa aaaagacagt actaaatgga gaaaattagt agatttcaga gaacttaata     9840

agagaactca agatttctgg gaagttcaat taggaatacc acatcctgca gggttaaaac     9900

agaaaaaatc agtaacagta ctggatgtgg gcgatgcata tttttcagtt cccttagata     9960

aagacttcag gaagtatact gcatttacca tacctagtat aaacaatgag acaccaggga    10020

ttagatatca gtacaatgtg cttccacagg gatggaaagg atcaccagca atattccagt    10080

gtagcatgac aaaaatctta gagcctttta gaaaacaaaa tccagacata gtcatctatc    10140

aatacatgga tgatttgtat gtaggatctg acttagaaat agggcagcat agaacaaaaa    10200

tagaggaact gagacaacat ctgttgaggt ggggatttac cacaccagac aaaaaacatc    10260

agaaagaacc tccattcctt tggatgggtt atgaactcca tcctgataaa tggacagtac    10320

agcctatagt gctgccagaa aaggacagct ggactgtcaa tgacatacag aaattagtgg    10380

gaaaattgaa ttgggcaagt cagatttatg cagggattaa agtaaggcaa ttatgtaaac    10440

ttcttagggg aaccaaagca ctaacagaag tagtaccact aacagaagaa gcagagctag    10500

aactggcaga aaacagggag attctaaaag aaccggtaca tggagtgtat tatgacccat    10560

caaaagactt aatagcagaa atacagaagc aggggcaagg ccaatggaca tatcaaattt    10620

atcaagagcc atttaaaaat ctgaaaacag gaaagtatgc aagaatgaag ggtgcccaca    10680

ctaatgatgt gaaacaatta acagaggcag tacaaaaaat agccacagaa agcatagtaa    10740

tatggggaaa gactcctaaa tttaaattac ccatacaaaa ggaaacatgg gaagcatggt    10800

ggacagagta ttggcaagcc acctggattc ctgagtggga gtttgtcaat acccctccct    10860

tagtgaagtt atggtaccag ttagagaaag aacccataat aggagcagaa actttctatg    10920

tagatggggc agccaatagg gaaactaaat taggaaaagc aggatatgta actgacagag    10980

gaagacaaaa agttgtcccc ctaacggaca caacaaatca gaagactgag ttacaagcaa    11040

ttcatctagc tttgcaggat tcgggattag aagtaaacat agtgacagac tcacaatatg    11100

cattgggaat cattcaagca caaccagata agagtgaatc agagttagtc agtcaaataa    11160

tagagcagtt aataaaaaag gaaaaagtct acctggcatg ggtaccagca cacaaaggaa    11220

ttggaggaaa tgaacaagta gataaattgg tcagtgctgg aatcaggaaa gtactatttt    11280

tagatggaat agataaggcc caagaagaac atgagaaata tcacagtaat tggagagcaa    11340

tggctagtga ttttaaccta ccacctgtag tagcaaaaga aatagtagcc agctgtgata    11400

aatgtcagct aaaaggggaa gccatgcatg gacaagtaga ctgtagccca ggaatatggc    11460

agctagattg tacacattta gaaggaaaag ttatcttggt agcagttcat gtagccagtg    11520

gatatataga agcagaagta attccagcag agacagggca agaaacagca tacttcctct    11580

taaaattagc aggaagatgg ccagtaaaaa cagtacatac agacaatggc agcaatttca    11640

ccagtactac agttaaggcc gcctgttggt gggcggggat caagcaggaa tttggcattc    11700

cctacaatcc ccaaagtcaa ggagtaatag aatctatgaa taaagaatta aagaaaatta    11760

taggacaggt aagagatcag gctgaacatc ttaagacagc agtacaaatg gcagtattca    11820

tccacaattt tcaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag    11880

acataatagc aacagacata caaactaaag aattattaaa attaattaca aaaattcaaa    11940

attttcgggt ttattacagg gacagcagag atccagtttg gaaaggacca gcaaagctcc    12000

tctggaaagg tgaaggggca gtagtaatac aagataatag tgacataaaa gtagtgccaa    12060

gaagaaaagc aaagatcatc agggattatg gaaaacagat ggcaggtgat gattgtgtgg    12120

caagtagaca ggatgaggat taacacatgg                                     12150


<210>  15
<211>  12150
<212>  DNA
<213>  Artificial

<220>
<223>  Transcomplementation P124 (p8.91-N) plasmid sequence

<400>  15
aattctgcaa caactgctgt ttatccattt cagaattggg tgtcgacata gcagaatagg       60

cgttactcga cagaggagag caagaaatgg agccagtaga tcctagacta gagccctgga      120

agcatccagg aagtcagcct aaaactgctt gtaccaattg ctattgtaaa aagtgttgct      180

ttcattgcca agtttgtttc atgacaaaag ccttaggcat ctcctatggc aggaagaagc      240

ggagacagcg acgaagagct catcagaaca gtcagactca tcaagcttct ctatcaaagc      300

agtaagtagt acatgtaatg caacctataa tagtagcaat agtagcatta gtagtagcaa      360

taataatagc aatagttgtg tggtccatag taatcataga atataggaaa atggccgctg      420

atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat      480

aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg      540

cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca      600

ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct      660

ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg      720

caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac      780

ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact      840

gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg      900

acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt      960

gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg     1020

gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata     1080

atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat     1140

agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga     1200

cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt     1260

cgattagtga acggatcctt ggcacttatc tgggacgatc tgcggagcct gtgcctcttc     1320

agctaccacc gcttgagaga cttactcttg attgtaacga ggattgtgga acttctggga     1380

cgcagggggt gggaagccct caaatattgg tggaatctcc tacaatattg gagtcaggag     1440

ctaaagaata gtgctgttag cttgctcaat gccacagcca tagcagtagc tgaggggaca     1500

gatagggtta tagaagtagt acaaggagct tgtagagcta ttcgccacat acctagaaga     1560

ataagacagg gcttggaaag gattttgcta taagctcgag gccgccccgg tgaccttcag     1620

accttggcac tggaggtggc ccggcagaag cgcggcatcg tggatcagtg ctgcaccagc     1680

atctgctctc tctaccaact ggagaactac tgcaactagg cccaccacta ccctgtccac     1740

ccctctgcaa tgaataaaac ctttgaaaga gcactacaag ttgtgtgtac atgcgtgcat     1800

gtgcatatgt ggtgcggggg gaacatgagt ggggctggct ggagtggcga tgataagctg     1860

tcaaacatga gaattaattc ttgaagacga aagggcctcg tgatacgcct atttttatag     1920

gttaatgtca tgataataat ggtttcttag tctagaatta attccgtgta ttctatagtg     1980

tcacctaaat cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa     2040

cgacaatatg tacaagccta attgtgtagc atctggctta ctgaagcaga ccctatcatc     2100

tctctcgtaa actgccgtca gagtcggttt ggttggacga accttctgag tttctggtaa     2160

cgccgtcccg cacccggaaa tggtcagcga accaatcagc agggtcatcg ctagccagat     2220

cctctacgcc ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc     2280

ctatatcgcc gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc     2340

ttgtttcggc gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc     2400

cttgcatgca ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg     2460

cttcctaatg caggagtcgc ataagggaga gcgtcgaatg gtgcactctc agtacaatct     2520

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     2700

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     2760

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     2820

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     2880

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     2940

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     3000

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     3060

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     3120

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     3180

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     3240

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     3300

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     3360

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     3420

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     3480

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     3540

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     3600

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     3660

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     3720

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     3780

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     3840

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     3900

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     3960

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     4020

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     4080

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     4140

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     4200

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     4260

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     4320

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     4380

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     4440

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     4500

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     4560

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     4620

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     4680

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4740

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     4800

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     4860

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     4920

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     4980

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     5040

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt     5100

gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag     5160

acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac     5220

ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga     5280

gcgaaaaata catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc     5340

gactgatgcc ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc     5400

gggtgcgtta ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag     5460

ctacgatcac gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga     5520

aggcttcatc gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga     5580

aatgtatcca aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt     5640

tgatgactat gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg     5700

cgtcgtattc gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg     5760

cgttgttctt tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg     5820

catccatgac acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg     5880

aaacctcgac gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc     5940

ttgatggtaa aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc     6000

gcggcattga cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg     6060

aacgtaccga cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt     6120

atgagtgggc cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac     6180

aaactaccta cagagattta aagctctaag gtaaatataa aatttttaac ccggatcttt     6240

gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa     6300

agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt     6360

gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc     6420

tttaatgagg aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact     6480

gctgactctc aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac     6540

tttccttcag aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct     6600

tgctttgcta tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa     6660

aaatattctg taacctttat aagtaggcat aacagttata atcataacat actgtttttt     6720

cttactccac acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc     6780

tttagctttt taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact     6840

agagatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     6900

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgttg ggctgcagga     6960

attaattcga gctcgcccga cattgattat tgactagtta ttaatagtaa tcaattacgg     7020

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     7080

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     7140

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     7200

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     7260

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     7320

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     7380

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     7440

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     7500

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     7560

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata     7620

gaagacaccg ggaccgatcc agcctccgcg gccgggaacg gtgcattgga acgcggattc     7680

cccgtgccaa gagtgacgta agtaccgcct atagagtcta taggcccacc cccttggctt     7740

cttatgcgac ggatcgatcc cgtaataagc ttcgaggtcc gcggccggcc gcgttgacgc     7800

gcacggcaag aggcgagggg cggcgactgg tgagagatgg gtgcgagagc gtcagtatta     7860

agcgggggag aattagatcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa     7920

tataaattaa aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct     7980

ggcctgttag aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt     8040

cagacaggat cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg     8100

catcaaagga tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa     8160

aacaaaagta agaaaaaagc acagcaagca gcagctgaca caggacacag caatcaggtc     8220

agccaaaatt accctatagt gcagaacatc caggggcaaa tggtacatca ggccatatca     8280

cctagaactt taaatgcatg ggtaaaagta gtagaagaga aggctttcag cccagaagtg     8340

atacccatgt tttcagcatt atcagaagga gccaccccac aagatttaaa caccatgcta     8400

aacacagtgg ggggacatca agcagccatg caaatgttaa aagagaccat caatgaggaa     8460

gctgcagaat gggatagagt gcatccagtg catgcagggc ctattgcacc aggccagatg     8520

agagaaccaa ggggaagtga catagcagga actactagta cccttcagga acaaatagga     8580

tggatgacac ataatccacc tatcccagta ggagaaatct ataaaagatg gataatcctg     8640

ggattaaata aaatagtaag aatgtatagc cctaccagca ttctggacat aagacaagga     8700

ccaaaggaac cctttagaga ctatgtagac cgattctata aaactctaag agccgagcaa     8760

gcttcacaag aggtaaaaaa ttggatgaca gaaaccttgt tggtccaaaa tgcgaaccca     8820

gattgtaaga ctattttaaa agcattggga ccaggagcga cactagaaga aatgatgaca     8880

gcatgtcagg gagtgggggg acccggccat aaagcaagag ttttggctga agcaatgagc     8940

caagtaacaa atccagctac cataatgata cagaaaggca attttaggaa ccaaagaaag     9000

actgttaagt gtttcaattg tggcaaagaa gggcacatag ccaaaaattg cagggcccct     9060

aggaaaaagg gctgttggaa atgtggaaag gaaggacacc aaatgaaaga ttgtactgag     9120

agacaggcta attttttagg gaagatctgg ccttcccaca agggaaggcc agggaatttt     9180

cttcagagca gaccagagcc aacagcccca ccagaagaga gcttcaggtt tggggaagag     9240

acaacaactc cctctcagaa gcaggagccg atagacaagg aactgtatcc tttagcttcc     9300

ctcagatcac tctttggcag cgacccctcg tcacaataaa gatagggggg caattaaagg     9360

aagctctatt agatacagga gcagatgata cagtattaga agaaatgaat ttgccaggaa     9420

gatggaaacc aaaaatgata gggggaattg gaggttttat caaagtaaga cagtatgatc     9480

agatactcat agaaatctgc ggacataaag ctataggtac agtattagta ggacctacac     9540

ctgtcaacat aattggaaga aatctgttga ctcagattgg ctgcacttta aattttccca     9600

ttagtcctat tgagactgta ccagtaaaat taaagccagg aatggatggc ccaaaagtta     9660

aacaatggcc attgacagaa gaaaaaataa aagcattagt agaaatttgt acagaaatgg     9720

aaaaggaagg aaaaatttca aaaattgggc ctgaaaatcc atacaatact ccagtatttg     9780

ccataaagaa aaaagacagt actaaatgga gaaaattagt agatttcaga gaacttaata     9840

agagaactca agatttctgg gaagttcaat taggaatacc acatcctgca gggttaaaac     9900

agaaaaaatc agtaacagta ctggatgtgg gcgatgcata tttttcagtt cccttagata     9960

aagacttcag gaagtatact gcatttacca tacctagtat aaacaatgag acaccaggga    10020

ttagatatca gtacaatgtg cttccacagg gatggaaagg atcaccagca atattccagt    10080

gtagcatgac aaaaatctta gagcctttta gaaaacaaaa tccagacata gtcatctatc    10140

aatacatgga tgatttgtat gtaggatctg acttagaaat agggcagcat agaacaaaaa    10200

tagaggaact gagacaacat ctgttgaggt ggggatttac cacaccagac aaaaaacatc    10260

agaaagaacc tccattcctt tggatgggtt atgaactcca tcctgataaa tggacagtac    10320

agcctatagt gctgccagaa aaggacagct ggactgtcaa tgacatacag aaattagtgg    10380

gaaaattgaa ttgggcaagt cagatttatg cagggattaa agtaaggcaa ttatgtaaac    10440

ttcttagggg aaccaaagca ctaacagaag tagtaccact aacagaagaa gcagagctag    10500

aactggcaga aaacagggag attctaaaag aaccggtaca tggagtgtat tatgacccat    10560

caaaagactt aatagcagaa atacagaagc aggggcaagg ccaatggaca tatcaaattt    10620

atcaagagcc atttaaaaat ctgaaaacag gaaagtatgc aagaatgaag ggtgcccaca    10680

ctaatgatgt gaaacaatta acagaggcag tacaaaaaat agccacagaa agcatagtaa    10740

tatggggaaa gactcctaaa tttaaattac ccatacaaaa ggaaacatgg gaagcatggt    10800

ggacagagta ttggcaagcc acctggattc ctgagtggga gtttgtcaat acccctccct    10860

tagtgaagtt atggtaccag ttagagaaag aacccataat aggagcagaa actttctatg    10920

tagatggggc agccaatagg gaaactaaat taggaaaagc aggatatgta actgacagag    10980

gaagacaaaa agttgtcccc ctaacggaca caacaaatca gaagactgag ttacaagcaa    11040

ttcatctagc tttgcaggat tcgggattag aagtaaacat agtgacagac tcacaatatg    11100

cattgggaat cattcaagca caaccagata agagtgaatc agagttagtc agtcaaataa    11160

tagagcagtt aataaaaaag gaaaaagtct acctggcatg ggtaccagca cacaaaggaa    11220

ttggaggaaa tgaacaagta gataaattgg tcagtgctgg aatcaggaaa gtactatttt    11280

tagatggaat agataaggcc caagaagaac atgagaaata tcacagtaat tggagagcaa    11340

tggctagtga ttttaaccta ccacctgtag tagcaaaaga aatagtagcc agctgtgata    11400

aatgtcagct aaaaggggaa gccatgcatg gacaagtaga ctgtagccca ggaatatggc    11460

agctagattg tacacattta gaaggaaaag ttatcttggt agcagttcat gtagccagtg    11520

gatatataga agcagaagta attccagcag agacagggca agaaacagca tacttcctct    11580

taaaattagc aggaagatgg ccagtaaaaa cagtacatac agacaatggc agcaatttca    11640

ccagtactac agttaaggcc gcctgttggt gggcggggat caagcaggaa tttggcattc    11700

cctacaatcc ccaaagtcaa ggagtaatag aatctatgaa taaagaatta aagaaaatta    11760

taggacaggt aagagatcag gctgaacatc ttaagacagc agtacaaatg gcagtattca    11820

tccacaattt taaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag    11880

acataatagc aacagacata caaactaaag aattacaaaa acaaattaca aaaattcaaa    11940

attttcgggt ttattacagg gacagcagag atccagtttg gaaaggacca gcaaagctcc    12000

tctggaaagg tgaaggggca gtagtaatac aagataatag tgacataaaa gtagtgcctg    12060

cagcacatgc aaagatcatc agggattatg gaaaacagat ggcaggtgat gattgtgtgg    12120

caagtagaca ggatgaggat taacacatgg                                     12150


<210>  16
<211>  5824
<212>  DNA
<213>  Artificial

<220>
<223>  P31 (VSV-pMD2.G) envelope plasmid sequence

<400>  16
ggatcccctg agggggcccc catgggctag aggatccggc ctcggcctct gcataaataa       60

aaaaaattag tcagccatga gcttggccca ttgcatacgt tgtatccata tcataatatg      120

tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt      180

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt      240

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg      300

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg      360

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt      420

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg      480

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg      540

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt      600

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      660

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      720

tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat      780

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccc ctcgaagctt      840

acatgtggta ccgagctcgg atcctgagaa cttcagggtg agtctatggg acccttgatg      900

ttttctttcc ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag      960

ggtacacata ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct     1020

tcttttaata tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc     1080

agggcaataa tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat     1140

aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg     1200

taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct     1260

tttattttat ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta     1320

atcatgttca tacctcttat cttcctccca cagctcctgg gcaacgtgct ggtctgtgtg     1380

ctggcccatc actttggcaa agcacgtgag atctgaattc aacagagatc gatctgtttc     1440

cttgacacta tgaagtgcct tttgtactta gcctttttat tcattggggt gaattgcaag     1500

ttcaccatag tttttccaca caaccaaaaa ggaaactgga aaaatgttcc ttctaattac     1560

cattattgcc cgtcaagctc agatttaaat tggcataatg acttaatagg cacagccata     1620

caagtcaaaa tgcccaagag tcacaaggct attcaagcag acggttggat gtgtcatgct     1680

tccaaatggg tcactacttg tgatttccgc tggtatggac cgaagtatat aacacagtcc     1740

atccgatcct tcactccatc tgtagaacaa tgcaaggaaa gcattgaaca aacgaaacaa     1800

ggaacttggc tgaatccagg cttccctcct caaagttgtg gatatgcaac tgtgacggat     1860

gccgaagcag tgattgtcca ggtgactcct caccatgtgc tggttgatga atacacagga     1920

gaatgggttg attcacagtt catcaacgga aaatgcagca attacatatg ccccactgtc     1980

cataactcta caacctggca ttctgactat aaggtcaaag ggctatgtga ttctaacctc     2040

atttccatgg acatcacctt cttctcagag gacggagagc tatcatccct gggaaaggag     2100

ggcacagggt tcagaagtaa ctactttgct tatgaaactg gaggcaaggc ctgcaaaatg     2160

caatactgca agcattgggg agtcagactc ccatcaggtg tctggttcga gatggctgat     2220

aaggatctct ttgctgcagc cagattccct gaatgcccag aagggtcaag tatctctgct     2280

ccatctcaga cctcagtgga tgtaagtcta attcaggacg ttgagaggat cttggattat     2340

tccctctgcc aagaaacctg gagcaaaatc agagcgggtc ttccaatctc tccagtggat     2400

ctcagctatc ttgctcctaa aaacccagga accggtcctg ctttcaccat aatcaatggt     2460

accctaaaat actttgagac cagatacatc agagtcgata ttgctgctcc aatcctctca     2520

agaatggtcg gaatgatcag tggaactacc acagaaaggg aactgtggga tgactgggca     2580

ccatatgaag acgtggaaat tggacccaat ggagttctga ggaccagttc aggatataag     2640

tttcctttat acatgattgg acatggtatg ttggactccg atcttcatct tagctcaaag     2700

gctcaggtgt tcgaacatcc tcacattcaa gacgctgctt cgcaacttcc tgatgatgag     2760

agtttatttt ttggtgatac tgggctatcc aaaaatccaa tcgagcttgt agaaggttgg     2820

ttcagtagtt ggaaaagctc tattgcctct tttttcttta tcatagggtt aatcattgga     2880

ctattcttgg ttctccgagt tggtatccat ctttgcatta aattaaagca caccaagaaa     2940

agacagattt atacagacat agagatgaac cgacttggaa agtaactcaa atcctgcaca     3000

acagattctt catgtttgga ccaaatcaac ttgtgatacc atgctcaaag aggcctcaat     3060

tatatttgag tttttaattt ttatggaatt caccccacca gtgcaggctg cctatcagaa     3120

agtggtggct ggtgtggcta atgccctggc ccacaagttt cactaagctc gcttccttgc     3180

tgtccaattt ctattaaagg ttccttggtt ccctaagtcc aactactaaa ctgggggata     3240

ttatgaaggg ccttgagcat ctggattctg cctaataaaa aacatttatt ttcattgcaa     3300

tgatgtattt aaattatttc tgaatatttt actaaaaagg gaatgtggga ggtcagtgca     3360

tttaaaacat aaagaaatga agagctagtt caaaccttgg gaaaatacac tatatcttaa     3420

actccatgaa agaaggtgag gctgcaaaca gctaatgcac attggcaaca gccctgatgc     3480

ctatgcctta ttcatccctc agaaaaggat tcaagtagag gcttgatttg gaggttaaag     3540

tttggctatg ctgtatttta cattacttat tgttttagct gtcctcatga atgtcttttc     3600

actacccatt tgcttatcct gcatctctca gccttgactc cactcagttc tcttgcttag     3660

agataccacc tttcccctga agtgttcctt ccatgtttta cggcgagatg gtttctcctc     3720

gcctggccac tcagccttag ttgtctctgt tgtcttatag aggtctactt gaagaaggaa     3780

aaacaggggg catggtttga ctgtcctgtg agcccttctt ccctgcctcc cccactcaca     3840

gtgacccgga atccctcgac atggcagtct agcactagtg cggccgcaga tctgcttcct     3900

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     3960

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4020

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4080

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4140

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4200

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4260

ctcaatgctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4320

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4380

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     4440

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     4500

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     4560

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     4620

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     4680

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     4740

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     4800

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     4860

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     4920

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     4980

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5040

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     5100

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     5160

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     5220

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     5280

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     5340

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     5400

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     5460

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     5520

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     5580

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     5640

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     5700

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     5760

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     5820

acgt                                                                  5824


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Murine p53 forward PCR primer sequence

<400>  17
actttaacag cagtctctgg g                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Murine p53 reverse PCR primer sequence

<400>  18
gaggaggaga cttcatttag g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Porcine p53 forward PCR primer sequence

<400>  19
agccgcctga ggtctggttt g                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Porcine p53 reverse PCR primer sequence

<400>  20
cacaaacacg cacctcaaag c                                                 21


<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F1 Zinc finger domain amino acid sequence (i)

<400>  21

Arg Ser Ser His Leu Ser Arg 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F2 Zinc finger domain amino acid sequence (i)

<400>  22

Arg Asn Asp Asn Arg Lys Thr 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F3 Zinc finger domain amino acid sequence (i)

<400>  23

Arg Ser Ser Asn Leu Ser Gln 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F4 Zinc finger domain amino acid sequence (i)

<400>  24

Asp Asn Ser Ser Arg Ile Arg 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F1 Zinc finger domain amino acid sequence (ii)

<400>  25

Arg Asn Ser Ser Leu Thr Asn 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F2 Zinc finger domain amino acid sequence (ii)

<400>  26

Ala Thr Asn Ser Leu Ile Glu 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F3 Zinc finger domain amino acid sequence (ii)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = G/C

<400>  27

Arg Ser Xaa His Leu Lys Thr 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F4 Zinc finger domain amino acid sequence (ii)

<400>  28

Arg Ser Asp Asn Leu Lys Thr 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F1 Zinc finger domain amino acid sequence (iii)

<400>  29

Arg Ser Asp Thr Leu Ser Arg 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F2 Zinc finger domain amino acid sequence (iii)

<400>  30

Arg Lys Asp Ala Arg Ile Asn 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F3 Zinc finger domain amino acid sequence (iii)

<400>  31

Arg Ser Ser His Leu Ser Thr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F4 Zinc finger domain amino acid sequence (iii)

<400>  32

Lys Ser Asp Asn Arg Thr Thr 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F1 Zinc finger domain amino acid sequence (iv)

<400>  33

Arg Ser Asp Asn Leu Ile Val 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F2 Zinc finger domain amino acid sequence (iv)

<400>  34

Gln Asn Ala Asn Arg Asn Thr 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F3 Zinc finger domain amino acid sequence (iv)

<400>  35

Arg Ser Asp Ala Leu Ser Arg 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F4 Zinc finger domain amino acid sequence (iv)

<400>  36

Asn Ser Ser Asn Arg Thr Val 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F1 Zinc finger domain amino acid sequence (v)

<400>  37

Arg Ser Ser Asn Leu Ile Val 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F2 Zinc finger domain amino acid sequence (v)

<400>  38

Gln Asn Ala Asn Arg Asn Thr 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F3 Zinc finger domain amino acid sequence (v)

<400>  39

Arg Ser Ser Ala Leu Ser Arg 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  F4 Zinc finger domain amino acid sequence (v)

<400>  40

Asn Ser Ser Asn Arg Thr Val 
1               5           


<210>  41
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  41
ccaccatcca ctacaactac atgtgtaaca gt                                     32


<210>  42
<211>  32
<212>  DNA
<213>  Ovis aries

<400>  42
ccaccatcca ctacaacttc atgtgtaaca gc                                     32


<210>  43
<211>  32
<212>  DNA
<213>  Mus musculus

<400>  43
ccaccatcca ctacaagtac atgtgtaata gc                                     32


<210>  44
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Target nucleic acid sequence (i)

<400>  44
gccaagcagg gg                                                           12


<210>  45
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Target nucleic acid sequence (ii)

<400>  45
cagtggctca tg                                                           12


<210>  46
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Target nucleic acid sequence (iii)

<400>  46
tagtggatgg tg                                                           12


<210>  47
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Target nucleic acid sequence (iv)

<400>  47
catgtgtaac ag                                                           12


<210>  48
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Target nucleic acid sequence (v)

<400>  48
catgtgcaac ag                                                           12


<210>  49
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  49
tgacaatgtg taca                                                         14


<210>  50
<211>  14
<212>  DNA
<213>  Mus musculus

<400>  50
cgataatgtg taca                                                         14


<210>  51
<211>  14
<212>  DNA
<213>  Ovis aries

<400>  51
cgacaatgtg tact                                                         14


<210>  52
<211>  14
<212>  DNA
<213>  Sus scrofa

<400>  52
cgacaacgtg tact                                                         14


<210>  53
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Target_seqL1 nucleic acid sequence

<400>  53
accagttggt ctggtgtcaa                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer Target_seqR1 nucleic acid sequence

<400>  54
ctgaacttgt ggccgtttac                                                   20


<210>  55
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  Primer T7kozak_FWD nucleic acid sequence

<400>  55
tcgagtaata cgactcacta tagggagaaa caccatagat tgccatggcc gagcgcccct       60

tc                                                                      62


<210>  56
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer UnivQQR_R_NotI nucleic acid sequence

<400>  56
aaggaaaaaa gcggccgcaa aaggaaaagg atcctcatta aaagtttatc                  50


<210>  57
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  Wild type cleavage site in GFP nucleic acid sequence

<400>  57
ttcaag                                                                   6


<210>  58
<211>  5
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated cleavage site in GFP nucleic acid sequence through NHEJ

<400>  58
tcaag                                                                    5


<210>  59
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated cleavage site in GFP nucleic acid sequence through NHEJ

<400>  59
ttcaaaag                                                                 8


<210>  60
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated cleavage site in GFP nucleic acid sequence through NHEJ

<400>  60
ttctcaag                                                                 8


<210>  61
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated cleavage site in GFP nucleic acid sequence through NHEJ

<400>  61
ttcacg                                                                   6


<210>  62
<211>  6
<212>  DNA
<213>  Sus scrofa

<400>  62
caactt                                                                   6


<210>  63
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  z1166R binding site

<400>  63
caccatccac ta                                                           12


<210>  64
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  GFP forward PCR primer sequence

<400>  64
tttacttgta cagctcgtcc                                                   20


<210>  65
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  GFP reverse PCR primer sequence

<400>  65
aagctgaccc tgaagttca                                                    19


<210>  66
<211>  32
<212>  DNA
<213>  Sus scrofa


<220>
<221>  allele
<222>  (19)..(19)
<223>  w = a or t

<220>
<221>  allele
<222>  (26)..(26)
<223>  y = c or t

<220>
<221>  allele
<222>  (32)..(32)
<223>  y = c or t

<400>  66
ccaccatcca ctacaactwc atgtgyaaca gy                                     32


<210>  67
<211>  54
<212>  DNA
<213>  Sus scrofa

<400>  67
tcgtccccca ggtcggctct gactgtacca ccatccacta caacttcatg tgta             54


<210>  68
<211>  4128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALEN1 nucleic acid sequence

<400>  68
atggcatcct ccccgccgaa aaagaaaaga aaggtcagct ggaaggacgc aagcggatgg       60

agccgcatgc acgccgatcc gatccgaccg cggcggccca gccctgccag ggaacttctt      120

ccgggaccgc agcctgacag agtgcaaccc acggccgata ggggagtgtc ggcgcctgcg      180

ggcagccctt tggatggtct gcccgcgagg cggacagtct cgcgcactag attgccttca      240

cccccggcgc cctcgcctgc gttttcggcc ggatcgttta gcgatctgct cagacccttc      300

gatcctagcc ttctcgacac ctcgcttttg gattcaatgc ctgctgtcgg aacaccccat      360

accgcagcgg cacccgctga atgggatgag gcgcagtcgg cactcagagc ggccgacgat      420

cctccaccga ccgtacgcgt cgcagtgact gcagccaggc cgccaagagc caaacccgcg      480

ccgcgccgac gggctgccca gccgtcggat gcgtcgcccg cagcgcaagt cgaccttagg      540

accctggggt atagccaaca gcagcaggag aaaatcaagc caaaagtgag gtcgacagtc      600

gcccagcatc acgaagccct cgtcgggcat gggtttacac acgcacatat cgtggccttg      660

tcccaacacc cggcggcgct tggtactgtg gccgtaacgt accagcacat cattaccgca      720

ctcccggaag ccacgcacga ggacatcgtc ggggtgggca aacagtggag cggggcacgc      780

gctttggagg ccctcctcac ggatgcggga gaattgagag gaccgccgct ccagttggac      840

acgggacagt tggtgaagat cgctaagcgg ggaggtgtca cagccatgga agcggtgcac      900

gcgtcccgga atgccttgac gggagcaccg cttaatctta caccagcgca ggtcgtcgcg      960

atcgcatccc atgatggtgg taaacaagcg ttggaaaccg tgcagcggtt gctgcccgta     1020

ctgtgccaag atcacgggct gacacccgac caagtagtag cgatcgcgtc caataacgga     1080

gggaaacagg cactcgagac ggtgcaacga ctgctgcctg tgctctgcca agaccacgga     1140

ctgacaccgg atcaagtggt ggcaattgca tcgaacggag ggggaaaaca ggcccttgag     1200

actgtacaaa gactcctgcc ggtgttgtgc caggaccatg gactgactcc tgatcaggta     1260

gtggctattg caagccacga tgggggaaaa caagcgctcg aaacggtgca gcgcctcctt     1320

cccgtcctct gccaagatca cggtttgacg ccagatcagg tagtcgcgat tgcatcgcac     1380

gatggaggaa aacaggcttt ggagacggta cagagattgc ttcctgtatt gtgtcaagac     1440

catgggctca cgccggacca ggtggtggcc atcgcgagcc acgacggagg taagcaggct     1500

ttggagactg tgcagcggct tctccccgtc ttgtgccaag accacgggct cacacctgac     1560

caggtggtcg ccatcgcatc acacgatggc gggaaacaag ctctggagac agtccagaga     1620

ctcctcccgg tcctttgcca ggatcacgga cttacgcccg atcaggtcgt agctatcgcc     1680

tcccatgacg ggggcaagca ggcgttggaa acagtccaga ggttgcttcc cgtactgtgc     1740

caggatcacg ggttgacgcc ggatcaggtc gtggcgatcg cgtccaacat tggtggaaag     1800

caagcgctcg aaacagtgca gaggttgttg cccgtgcttt gtcaagacca cggtctgact     1860

ccggatcaag tagtcgccat tgcgtcaaac aacggcggga agcaggcact tgaaacagta     1920

caacgcttgc tgccggtact ttgccaggac catgggttga cgccggatca ggtagtggca     1980

atcgcctcaa acaacggcgg gaagcaggct ctggaaactg tccaacgact tctccctgtg     2040

ctgtgtcagg accatggact cacgcccgac caagtagtgg cgattgcgtc gaacgggggt     2100

ggcaaacagg cgctcgagac agtccagcgg ctgcttccag tcctgtgtca ggatcatggg     2160

ctgactccag accaagtggt ggcgatcgcc tcacacgacg ggggaaagca agctcttgag     2220

acggtccaga gattgctgcc agtcttgtgt caagatcacg gactgactcc cgatcaggta     2280

gtagcgattg cctccaataa tggtggtaag caagcccttg aaacggtcca aagactcctt     2340

cctgtacttt gtcaggatca cggtctgacg cccgatcaag tcgtagcaat tgcgtcgaat     2400

aatggaggta aacaggcgct cgaaaccgtc caaagactgc tccccgtgct gtgtcaggac     2460

catggcctta cgcccgacca ggtcgtcgca atcgcttcgc acgacggcgg aaaacaagcc     2520

cttgaaacgg tccagcgcct cctcccggtc ctttgtcagg atcatggtct tacgccggac     2580

caggtggtgg ctatcgccag caatggagga ggaaagcagg cattggaaac ggtgcagagg     2640

cttcttccgg tgctctgtca ggaccacggc cttacgcctg atcaagtagt cgccatcgcg     2700

tcgcatgacg gaggaaaaca agccttggaa acagtccaaa ggctgctccc cgtcctctgt     2760

caggatcacg gtctgacccc agaccaggtc gtcgcaattg cttccaatgg tgggggaaag     2820

caagcattgg agtcaatcgt cgcgcagctc tcacgaagag accctgctct cgccgcgttg     2880

accaacgatc acttggtggc cttggcatgc cttggtggac gacccgcatt ggacgcggta     2940

aagaagggcc tcccccatgc gccagagttc atccgacgcg tgaatcgccg gattgcggag     3000

cgaacctccc accgcgtagc tgactacgca cacgtggtca gagtccttga gtttttccag     3060

tgccactccc atcccgccca cgcgttcgac gaggcgatga ctcagtttgg tatgtcgcga     3120

catgggctgg tgcagctctt ccgacgagtc ggggtgaccg agttcgaggc cagatacggg     3180

actttgcctc ccgcctcaca gcgctgggac cgcatcttgc aggccagcgg catgaaaagg     3240

gcgaagccga gccccacgtc ggctcaaacg cctgaccaga cctcgcttca cgcctttgcg     3300

gactccctgg agcgcgacct tgacgcaccc agcccaatgc atgagggaga tcaaactcgg     3360

gcgtcgtcgc ggaaaagatc gagatcggac agggccgtga caggaccgtc ggcccagcag     3420

gcagtggagg tcagggtacc cgagcagagg gacgcgcttc acctccccct ttcatggcga     3480

gtcaagcgac ctcggactag aatctgggga gggttgccag atccgatctc aaggtcgcag     3540

ctggtgaagt cggaactgga ggaaaagaag tccgagcttc gccacaagct caagtatgtc     3600

ccccacgaat acattgaact tatcgaaatc gcaagaaaca gcacccagga caggattttg     3660

gagatgaagg tcatggagtt cttcatgaag gtatatggtt atagggggaa gcatctcgga     3720

ggatcgcgaa agccagacgg agcgatctac acagtgggat cacccatcga ttacggggtg     3780

atcgtcgaca ccaaggcgta cagcggaggt tataatctgc ccatcgggca ggcagatgaa     3840

atgcagcgct atgtgaagga aaatcagacc cgcaacaaac acatcaatcc caacgagtgg     3900

tggaaagtat acccctcatc agtaacggag tttaagttcc ttttcgtatc cggacacttc     3960

aagggaaact acaaggctca gctcactaga ctgaaccata aaactaactg caacggggcg     4020

gtcctgtccg tcgaagagct gctcatcggt ggggaaatga ttaaggcggg aacactcacg     4080

ttggaggagg tacgccgcaa attcaataac ggtgagatta acttctga                  4128


<210>  69
<211>  3924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALEN2 nucleic acid sequence

<400>  69
atggcatcct ccccgccgaa aaagaaaaga aaggtcagct ggaaggacgc aagcggatgg       60

agccgcatgc acgccgatcc gatccgaccg cggcggccca gccctgccag ggaacttctt      120

ccgggaccgc agcctgacag agtgcaaccc acggccgata ggggagtgtc ggcgcctgcg      180

ggcagccctt tggatggtct gcccgcgagg cggacagtct cgcgcactag attgccttca      240

cccccggcgc cctcgcctgc gttttcggcc ggatcgttta gcgatctgct cagacccttc      300

gatcctagcc ttctcgacac ctcgcttttg gattcaatgc ctgctgtcgg aacaccccat      360

accgcagcgg cacccgctga atgggatgag gcgcagtcgg cactcagagc ggccgacgat      420

cctccaccga ccgtacgcgt cgcagtgact gcagccaggc cgccaagagc caaacccgcg      480

ccgcgccgac gggctgccca gccgtcggat gcgtcgcccg cagcgcaagt cgaccttagg      540

accctggggt atagccaaca gcagcaggag aaaatcaagc caaaagtgag gtcgacagtc      600

gcccagcatc acgaagccct cgtcgggcat gggtttacac acgcacatat cgtggccttg      660

tcccaacacc cggcggcgct tggtactgtg gccgtaacgt accagcacat cattaccgca      720

ctcccggaag ccacgcacga ggacatcgtc ggggtgggca aacagtggag cggggcacgc      780

gctttggagg ccctcctcac ggatgcggga gaattgagag gaccgccgct ccagttggac      840

acgggacagt tggtgaagat cgctaagcgg ggaggtgtca cagccatgga agcggtgcac      900

gcgtcccgga atgccttgac gggagcaccg cttaatctga ccccggctca agtagtcgcg      960

atcgcttcaa acatcggagg aaagcaggcg ctcgaaacag tacagcgctt gctccctgtg     1020

ttgtgccagg atcatggact gacaccagac caggtagtgg cgattgcttc gcacgatggg     1080

ggcaaacagg cccttgagac ggtacagcgg ttgttgcccg tactttgcca ggaccatggg     1140

ctgacacccg atcaagtggt ggcaattgcc agcaacattg gaggtaaaca agcgctcgaa     1200

acggtacaga gactccttcc cgtgttgtgc caggatcacg gactgacccc cgaccaggtg     1260

gtcgcgatcg cgtcacatga tggagggaaa caagcgttgg aaacagtcca gagactcctg     1320

ccagtccttt gccaagatca tggtctgacg cccgaccagg tggtggccat cgcttcgaat     1380

atcggaggga agcaggcact cgagacggtc cagaggttgt tgccggtact ctgtcaagac     1440

catgggctta cacctgacca ggtcgtggcc attgcgagca acggtggggg aaagcaagca     1500

cttgaaaccg tgcagagact gctcccggtg ctgtgtcaag accatggcct caccccagat     1560

caggtagtcg ccattgcatc caacaacggg ggtaagcagg ccttggaaac ggtgcaaagg     1620

ttgctccccg tactgtgcca agatcatggg ttgacgccag accaggtcgt ggcaatcgcc     1680

tccaacattg ggggcaagca agcgctggaa actgtgcaga ggctgttgcc tgtcctctgc     1740

caggatcatg ggctcacgcc cgatcaggta gtcgccatcg catccaatat cggtgggaag     1800

caagcccttg agactgtcca gcggttgctg cccgtgcttt gccaagacca cgggttgact     1860

cccgatcaag tagtagcgat tgcctcaaat aatgggggta aacaagcgct ggagacagtc     1920

cagagacttc ttcccgtgct ttgccaggat catggattga cccctgatca agtagtggcc     1980

atcgcctcaa acgggggagg aaagcaggca ttggagacgg tgcagagatt gctgcctgtg     2040

ctttgtcagg accacggact tacaccggat caggtcgtcg cgattgcaag caatgggggt     2100

ggtaaacagg cactggagac cgtgcagcga cttctcccag tgttgtgtca agatcacggt     2160

ctgactcctg accaagtcgt ggcgattgcg tccaataacg ggggaaaaca ggcgcttgaa     2220

acggtgcagc ggctcctccc ggtgctttgt caagatcacg ggctcacacc ggaccaggta     2280

gtggctatcg catcgaacgg gggaggaaaa caggcgcttg agacagtaca gaggcttctg     2340

cccgtgctgt gccaagacca cgggcttacg ccggatcaag tggtggccat cgcttcgaat     2400

attggtggca aacaggccct cgagacagtg caacggcttt tgcctgtact gtgtcaggat     2460

cacggcctca ctcctgacca ggtggtcgct attgcgtcga ataacggtgg gaaacaggca     2520

ttggagacgg tgcagcggct cctgccggtc ctctgtcagg accacggact cactccggat     2580

caagtcgtag ccattgcgtc gaacggagga ggaaagcagg cgctcgaatc aatcgtcgcg     2640

cagctctcac gaagagaccc tgctctcgcc gcgttgacca acgatcactt ggtggccttg     2700

gcatgccttg gtggacgacc cgcattggac gcggtaaaga agggcctccc ccatgcgcca     2760

gagttcatcc gacgcgtgaa tcgccggatt gcggagcgaa cctcccaccg cgtagctgac     2820

tacgcacacg tggtcagagt ccttgagttt ttccagtgcc actcccatcc cgcccacgcg     2880

ttcgacgagg cgatgactca gtttggtatg tcgcgacatg ggctggtgca gctcttccga     2940

cgagtcgggg tgaccgagtt cgaggccaga tacgggactt tgcctcccgc ctcacagcgc     3000

tgggaccgca tcttgcaggc cagcggcatg aaaagggcga agccgagccc cacgtcggct     3060

caaacgcctg accagacctc gcttcacgcc tttgcggact ccctggagcg cgaccttgac     3120

gcacccagcc caatgcatga gggagatcaa actcgggcgt cgtcgcggaa aagatcgaga     3180

tcggacaggg ccgtgacagg accgtcggcc cagcaggcag tggaggtcag ggtacccgag     3240

cagagggacg cgcttcacct ccccctttca tggcgagtca agcgacctcg gactagaatc     3300

tggggagggt tgccagatcc gatctcaagg tcgcagctgg tgaagtcgga actggaggaa     3360

aagaagtccg agcttcgcca caagctcaag tatgtccccc acgaatacat tgaacttatc     3420

gaaatcgcaa gaaacagcac ccaggacagg attttggaga tgaaggtcat ggagttcttc     3480

atgaaggtat atggttatag ggggaagcat ctcggaggat cgcgaaagcc agacggagcg     3540

atctacacag tgggatcacc catcgattac ggggtgatcg tcgacaccaa ggcgtacagc     3600

ggaggttata atctgcccat cgggcaggca gatgaaatgg aacgctatgt ggaagaaaat     3660

cagacccgca acaaacacct gaatcccaac gagtggtgga aagtataccc ctcatcagta     3720

acggagttta agttcctttt cgtatccgga cacttcaagg gaaactacaa ggctcagctc     3780

actagactga accatattac taactgcaac ggggcggtcc tgtccgtcga agagctgctc     3840

atcggtgggg aaatgattaa ggcgggaaca ctcacgttgg aggaggtacg ccgcaaattc     3900

aataacggtg agattaactt ctga                                            3924


<210>  70
<211>  14440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pt205 (Ptrip-CMV-TALEN1-WPRE) nucleic acid sequence

<400>  70
ttgtacaaag tggtgatcgc taccggactc agatccggcc catctgatgg gtcatcgagc       60

tcaagcttcg aattcccgat aatcaacctc tggattacaa aatttgtgaa agattgactg      120

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt      180

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc      240

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt      300

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga      360

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct      420

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga      480

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct      540

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc      600

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg      660

cctccccgca tcgggaattc tgcagtcgac ggtaccttta agaccaatga cttacaaggc      720

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc      780

ccaacgaaga caaaatcgtc gagagatgct gcatataagc agctgctttt tgcttgtact      840

gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca      900

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      960

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc     1020

agtagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca     1080

gagagtgaga ggccttgaca ttataataga tttagcagga attgaactag gagtggagca     1140

cacaggcaaa gctgcagaag tacttggaag aagccaccag agatactcac gattctgcac     1200

atacctggct aatcccagat cctaaggatt acattaagtt tactaacatt tatataatga     1260

tttatagttt aaagtataaa cttatctaat ttactattct gacagatatt aattaatcct     1320

caaatatcat aagagatgat tactattatc cccatttaac acaagaggaa actgagaggg     1380

aaagatgttg aagtaatttt cccacaatta cagcatccgt tagttacgac tctatgatct     1440

tctgacacaa attccattta ctcctcaccc tatgactcag tcgaatatat caaagttatg     1500

gacattatgc taagtaacaa attacccttt tatatagtaa atactgagta gattgagaga     1560

agaaattgtt tgcaaacctg aatagcttca agaagaagag aagtgaggat aagaataaca     1620

gttgtcattt aacaagtttt aacaagtaac ttggttagaa agggattcaa atgcataaag     1680

caagggataa atttttctgg caacaagact atacaatata accttaaata tgacttcaaa     1740

taattgttgg aacttgataa aactaattaa atattattga agattatcaa tattataaat     1800

gtaatttact tttaaaaagg gaacatagaa atgtgtatca ttagagtaga aaacaatcct     1860

tattatcaca atttgtcaaa acaagtttgt tattaacaca agtagaatac tgcattcaat     1920

taagttgact gcagattttg tgttttgtta aaattagaaa gagataacaa caatttgaat     1980

tattgaaagt aacatgtaaa tagttctaca tacgttcttt tgacatcttg ttcaatcatt     2040

gatcgaagtt ctttatcttg gaagaatttg ttccaaagac tctgaaataa ggaaaacaat     2100

ctattatata gtctcacacc tttgttttac ttttagtgat ttcaatttaa taatgtaaat     2160

ggttaaaatt tattcttctc tgagatcatt tcacattgca gatagaaaac ctgagactgg     2220

ggtaattttt attaaaatct aatttaatct cagaaacaca tctttattct aacatcaatt     2280

tttccagttt gatattatca tataaagtca gccttcctca tctgcaggtt ccacaacaaa     2340

aatccaacca actgtggatc aaaaatattg ggaaaaaatt aaaaatagca atacaacaat     2400

aaaaaaatac aaatcagaaa aacagcacag tataacaact ttatttagca tttacaatct     2460

attaggtatt ataagtaatc tagccagatc ctctacgccg gacgcatcgt ggccggcatc     2520

accggcgcca caggtgcggt tgctggcgcc tatatcgccg acatcaccga tggggaagat     2580

cgggctcgcc acttcgggct catgagcgct tgtttcggcg tgggtatggt ggcaggcccc     2640

gtggccgggg gactgttggg cgccatctcc ttgcatgcac cattccttgc ggcggcggtg     2700

ctcaacggcc tcaacctact actgggctgc ttcctaatgc aggagtcgca taagggagag     2760

cgtcgaatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     2820

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     2880

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     2940

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     3000

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     3060

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     3120

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     3180

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     3240

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3300

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     3360

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     3420

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     3480

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     3540

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     3600

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     3660

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     3720

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     3780

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     3840

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     3900

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     3960

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     4020

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     4080

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     4140

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     4200

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     4260

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4320

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     4380

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     4440

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     4500

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     4560

cctacagcgt gagcattgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     4620

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     4680

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     4740

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     4800

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     4860

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     4920

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     4980

cgcgcgttgg ccgattcatt aatgcagctg tggaatgtgt gtcagttagg gtgtggaaag     5040

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     5100

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5160

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     5220

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     5280

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     5340

tgcaaaaagc ttggacacaa gacaggcttg cgagatatgt ttgagaatac cactttatcc     5400

cgcgtcaggg agaggcagtg cgtaaaaaga cgcggactca tgtgaaatac tggtttttag     5460

tgcgccagat ctctataatc tcgcgcaacc tattttcccc tcgaacactt tttaagccgt     5520

agataaacag gctgggacac ttcacatgag cgaaaaatac atcgtcacct gggacatgtt     5580

gcagatccat gcacgtaaac tcgcaagccg actgatgcct tctgaacaat ggaaaggcat     5640

tattgccgta agccgtggcg gtctgtaccg ggtgcgttac tggcgcgtga actgggtatt     5700

cgtcatgtcg ataccgtttg tatttccagc tacgatcacg acaaccagcg cgagcttaaa     5760

gtgctgaaac gcgcagaagg cgatggcgaa ggcttcatcg ttattgatga cctggtggat     5820

accggtggta ctgcggttgc gattcgtgaa atgtatccaa aagcgcactt tgtcaccatc     5880

ttcgcaaaac cggctggtcg tccgctggtt gatgactatg ttgttgatat cccgcaagat     5940

acctggattg aacagccgtg ggatatgggc gtcgtattcg tcccgccaat ctccggtcgc     6000

taatcttttc aacgcctggc actgccgggc gttgttcttt ttaacttcag gcgggttaca     6060

atagtttcca gtaagtattc tggaggctgc atccatgaca caggcaaacc tgagcgaaac     6120

cctgttcaaa ccccgcttta aacatcctga aacctcgacg ctagtccgcc gctttaatca     6180

cggcgcacaa ccgcctgtgc agtcggccct tgatggtaaa accatccctc actggtatcg     6240

catgattaac cgtctgatgt ggatctggcg cggcattgac ccacgcgaaa tcctcgacgt     6300

ccaggcacgt attgtgatga gcgatgccga acgtaccgac gatgatttat acgatacggt     6360

gattggctac cgtggcggca actggattta tgagtgggcc ccggatcttt gtgaaggaac     6420

cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg     6480

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat     6540

tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg     6600

aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc     6660

aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag     6720

aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta     6780

tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg     6840

taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac     6900

acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt     6960

taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata     7020

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     7080

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     7140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     7200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcaactgg     7260

ataactcaag ctaaccaaaa tcatcccaaa cttcccaccc cataccctat taccactgcc     7320

aattacctag tggtttcatt tactctaaac ctgtgattcc tctgaattat tttcatttta     7380

aagaaattgt atttgttaaa tatgtactac aaacttagta gttggaaggg ctaattcact     7440

cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc tacttccctg     7500

attagcagaa ctacacacca gggccagggg tcagatatcc actgaccttt ggatggtgct     7560

acaagctagt accagttgag ccagataagg tagaagaggc caataaagga gagaacacca     7620

gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtgttagagt     7680

ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat ccggagtact     7740

tcaagaactg ctgatatcga gcttgctaca agggactttc cgctggggac tttccaggga     7800

ggcgtggcct gggcgggact ggggagtggc gagccctcag atcctgcata taagcagctg     7860

ctttttgcct gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc     7920

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     7980

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     8040

tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg     8100

agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc     8160

gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg     8220

agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc     8280

cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac     8340

gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac     8400

agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag     8460

caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca     8520

agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc     8580

agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta     8640

gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga     8700

gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc     8760

actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata     8820

gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc     8880

acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag     8940

gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg     9000

ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg     9060

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     9120

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     9180

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     9240

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     9300

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     9360

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     9420

gtgaacggat ctcgacggta tcgccgaatt cacaaatggc agtattcatc cacaatttta     9480

aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa     9540

cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt     9600

attacaggga cagcagagat ccactttggc tgatacgcgg atctacgcgt attaatagta     9660

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     9720

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     9780

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     9840

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     9900

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     9960

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt    10020

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca    10080

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg    10140

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta    10200

tataagcaga gctggtttag tgaaccgtca gatccgatca caagtttgta caaaaaagca    10260

ggctccttaa acatatgtgc cgccaccatg gcatcctccc cgccgaaaaa gaaaagaaag    10320

gtcagctgga aggacgcaag cggatggagc cgcatgcacg ccgatccgat ccgaccgcgg    10380

cggcccagcc ctgccaggga acttcttccg ggaccgcagc ctgacagagt gcaacccacg    10440

gccgataggg gagtgtcggc gcctgcgggc agccctttgg atggtctgcc cgcgaggcgg    10500

acagtctcgc gcactagatt gccttcaccc ccggcgccct cgcctgcgtt ttcggccgga    10560

tcgtttagcg atctgctcag acccttcgat cctagccttc tcgacacctc gcttttggat    10620

tcaatgcctg ctgtcggaac accccatacc gcagcggcac ccgctgaatg ggatgaggcg    10680

cagtcggcac tcagagcggc cgacgatcct ccaccgaccg tacgcgtcgc agtgactgca    10740

gccaggccgc caagagccaa acccgcgccg cgccgacggg ctgcccagcc gtcggatgcg    10800

tcgcccgcag cgcaagtcga ccttaggacc ctggggtata gccaacagca gcaggagaaa    10860

atcaagccaa aagtgaggtc gacagtcgcc cagcatcacg aagccctcgt cgggcatggg    10920

tttacacacg cacatatcgt ggccttgtcc caacacccgg cggcgcttgg tactgtggcc    10980

gtaacgtacc agcacatcat taccgcactc ccggaagcca cgcacgagga catcgtcggg    11040

gtgggcaaac agtggagcgg ggcacgcgct ttggaggccc tcctcacgga tgcgggagaa    11100

ttgagaggac cgccgctcca gttggacacg ggacagttgg tgaagatcgc taagcgggga    11160

ggtgtcacag ccatggaagc ggtgcacgcg tcccggaatg ccttgacggg agcaccgctt    11220

aatcttacac cagcgcaggt cgtcgcgatc gcatcccatg atggtggtaa acaagcgttg    11280

gaaaccgtgc agcggttgct gcccgtactg tgccaagatc acgggctgac acccgaccaa    11340

gtagtagcga tcgcgtccaa taacggaggg aaacaggcac tcgagacggt gcaacgactg    11400

ctgcctgtgc tctgccaaga ccacggactg acaccggatc aagtggtggc aattgcatcg    11460

aacggagggg gaaaacaggc ccttgagact gtacaaagac tcctgccggt gttgtgccag    11520

gaccatggac tgactcctga tcaggtagtg gctattgcaa gccacgatgg gggaaaacaa    11580

gcgctcgaaa cggtgcagcg cctccttccc gtcctctgcc aagatcacgg tttgacgcca    11640

gatcaggtag tcgcgattgc atcgcacgat ggaggaaaac aggctttgga gacggtacag    11700

agattgcttc ctgtattgtg tcaagaccat gggctcacgc cggaccaggt ggtggccatc    11760

gcgagccacg acggaggtaa gcaggctttg gagactgtgc agcggcttct ccccgtcttg    11820

tgccaagacc acgggctcac acctgaccag gtggtcgcca tcgcatcaca cgatggcggg    11880

aaacaagctc tggagacagt ccagagactc ctcccggtcc tttgccagga tcacggactt    11940

acgcccgatc aggtcgtagc tatcgcctcc catgacgggg gcaagcaggc gttggaaaca    12000

gtccagaggt tgcttcccgt actgtgccag gatcacgggt tgacgccgga tcaggtcgtg    12060

gcgatcgcgt ccaacattgg tggaaagcaa gcgctcgaaa cagtgcagag gttgttgccc    12120

gtgctttgtc aagaccacgg tctgactccg gatcaagtag tcgccattgc gtcaaacaac    12180

ggcgggaagc aggcacttga aacagtacaa cgcttgctgc cggtactttg ccaggaccat    12240

gggttgacgc cggatcaggt agtggcaatc gcctcaaaca acggcgggaa gcaggctctg    12300

gaaactgtcc aacgacttct ccctgtgctg tgtcaggacc atggactcac gcccgaccaa    12360

gtagtggcga ttgcgtcgaa cgggggtggc aaacaggcgc tcgagacagt ccagcggctg    12420

cttccagtcc tgtgtcagga tcatgggctg actccagacc aagtggtggc gatcgcctca    12480

cacgacgggg gaaagcaagc tcttgagacg gtccagagat tgctgccagt cttgtgtcaa    12540

gatcacggac tgactcccga tcaggtagta gcgattgcct ccaataatgg tggtaagcaa    12600

gcccttgaaa cggtccaaag actccttcct gtactttgtc aggatcacgg tctgacgccc    12660

gatcaagtcg tagcaattgc gtcgaataat ggaggtaaac aggcgctcga aaccgtccaa    12720

agactgctcc ccgtgctgtg tcaggaccat ggccttacgc ccgaccaggt cgtcgcaatc    12780

gcttcgcacg acggcggaaa acaagccctt gaaacggtcc agcgcctcct cccggtcctt    12840

tgtcaggatc atggtcttac gccggaccag gtggtggcta tcgccagcaa tggaggagga    12900

aagcaggcat tggaaacggt gcagaggctt cttccggtgc tctgtcagga ccacggcctt    12960

acgcctgatc aagtagtcgc catcgcgtcg catgacggag gaaaacaagc cttggaaaca    13020

gtccaaaggc tgctccccgt cctctgtcag gatcacggtc tgaccccaga ccaggtcgtc    13080

gcaattgctt ccaatggtgg gggaaagcaa gcattggagt caatcgtcgc gcagctctca    13140

cgaagagacc ctgctctcgc cgcgttgacc aacgatcact tggtggcctt ggcatgcctt    13200

ggtggacgac ccgcattgga cgcggtaaag aagggcctcc cccatgcgcc agagttcatc    13260

cgacgcgtga atcgccggat tgcggagcga acctcccacc gcgtagctga ctacgcacac    13320

gtggtcagag tccttgagtt tttccagtgc cactcccatc ccgcccacgc gttcgacgag    13380

gcgatgactc agtttggtat gtcgcgacat gggctggtgc agctcttccg acgagtcggg    13440

gtgaccgagt tcgaggccag atacgggact ttgcctcccg cctcacagcg ctgggaccgc    13500

atcttgcagg ccagcggcat gaaaagggcg aagccgagcc ccacgtcggc tcaaacgcct    13560

gaccagacct cgcttcacgc ctttgcggac tccctggagc gcgaccttga cgcacccagc    13620

ccaatgcatg agggagatca aactcgggcg tcgtcgcgga aaagatcgag atcggacagg    13680

gccgtgacag gaccgtcggc ccagcaggca gtggaggtca gggtacccga gcagagggac    13740

gcgcttcacc tccccctttc atggcgagtc aagcgacctc ggactagaat ctggggaggg    13800

ttgccagatc cgatctcaag gtcgcagctg gtgaagtcgg aactggagga aaagaagtcc    13860

gagcttcgcc acaagctcaa gtatgtcccc cacgaataca ttgaacttat cgaaatcgca    13920

agaaacagca cccaggacag gattttggag atgaaggtca tggagttctt catgaaggta    13980

tatggttata gggggaagca tctcggagga tcgcgaaagc cagacggagc gatctacaca    14040

gtgggatcac ccatcgatta cggggtgatc gtcgacacca aggcgtacag cggaggttat    14100

aatctgccca tcgggcaggc agatgaaatg cagcgctatg tgaaggaaaa tcagacccgc    14160

aacaaacaca tcaatcccaa cgagtggtgg aaagtatacc cctcatcagt aacggagttt    14220

aagttccttt tcgtatccgg acacttcaag ggaaactaca aggctcagct cactagactg    14280

aaccataaaa ctaactgcaa cggggcggtc ctgtccgtcg aagagctgct catcggtggg    14340

gaaatgatta aggcgggaac actcacgttg gaggaggtac gccgcaaatt caataacggt    14400

gagattaact tctgaggcgc ctcgagccga cccagctttc                          14440


<210>  71
<211>  14236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pt206 (Ptrip-CMV-TALEN2-WPRE) nucleic acid sequence

<400>  71
ttgtacaaag tggtgatcgc taccggactc agatccggcc catctgatgg gtcatcgagc       60

tcaagcttcg aattcccgat aatcaacctc tggattacaa aatttgtgaa agattgactg      120

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt      180

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc      240

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt      300

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga      360

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct      420

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga      480

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct      540

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc      600

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg      660

cctccccgca tcgggaattc tgcagtcgac ggtaccttta agaccaatga cttacaaggc      720

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc      780

ccaacgaaga caaaatcgtc gagagatgct gcatataagc agctgctttt tgcttgtact      840

gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca      900

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      960

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc     1020

agtagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca     1080

gagagtgaga ggccttgaca ttataataga tttagcagga attgaactag gagtggagca     1140

cacaggcaaa gctgcagaag tacttggaag aagccaccag agatactcac gattctgcac     1200

atacctggct aatcccagat cctaaggatt acattaagtt tactaacatt tatataatga     1260

tttatagttt aaagtataaa cttatctaat ttactattct gacagatatt aattaatcct     1320

caaatatcat aagagatgat tactattatc cccatttaac acaagaggaa actgagaggg     1380

aaagatgttg aagtaatttt cccacaatta cagcatccgt tagttacgac tctatgatct     1440

tctgacacaa attccattta ctcctcaccc tatgactcag tcgaatatat caaagttatg     1500

gacattatgc taagtaacaa attacccttt tatatagtaa atactgagta gattgagaga     1560

agaaattgtt tgcaaacctg aatagcttca agaagaagag aagtgaggat aagaataaca     1620

gttgtcattt aacaagtttt aacaagtaac ttggttagaa agggattcaa atgcataaag     1680

caagggataa atttttctgg caacaagact atacaatata accttaaata tgacttcaaa     1740

taattgttgg aacttgataa aactaattaa atattattga agattatcaa tattataaat     1800

gtaatttact tttaaaaagg gaacatagaa atgtgtatca ttagagtaga aaacaatcct     1860

tattatcaca atttgtcaaa acaagtttgt tattaacaca agtagaatac tgcattcaat     1920

taagttgact gcagattttg tgttttgtta aaattagaaa gagataacaa caatttgaat     1980

tattgaaagt aacatgtaaa tagttctaca tacgttcttt tgacatcttg ttcaatcatt     2040

gatcgaagtt ctttatcttg gaagaatttg ttccaaagac tctgaaataa ggaaaacaat     2100

ctattatata gtctcacacc tttgttttac ttttagtgat ttcaatttaa taatgtaaat     2160

ggttaaaatt tattcttctc tgagatcatt tcacattgca gatagaaaac ctgagactgg     2220

ggtaattttt attaaaatct aatttaatct cagaaacaca tctttattct aacatcaatt     2280

tttccagttt gatattatca tataaagtca gccttcctca tctgcaggtt ccacaacaaa     2340

aatccaacca actgtggatc aaaaatattg ggaaaaaatt aaaaatagca atacaacaat     2400

aaaaaaatac aaatcagaaa aacagcacag tataacaact ttatttagca tttacaatct     2460

attaggtatt ataagtaatc tagccagatc ctctacgccg gacgcatcgt ggccggcatc     2520

accggcgcca caggtgcggt tgctggcgcc tatatcgccg acatcaccga tggggaagat     2580

cgggctcgcc acttcgggct catgagcgct tgtttcggcg tgggtatggt ggcaggcccc     2640

gtggccgggg gactgttggg cgccatctcc ttgcatgcac cattccttgc ggcggcggtg     2700

ctcaacggcc tcaacctact actgggctgc ttcctaatgc aggagtcgca taagggagag     2760

cgtcgaatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     2820

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     2880

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     2940

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     3000

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     3060

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     3120

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     3180

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     3240

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3300

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     3360

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     3420

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     3480

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     3540

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     3600

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     3660

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     3720

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     3780

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     3840

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     3900

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     3960

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     4020

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     4080

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     4140

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     4200

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     4260

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4320

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     4380

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     4440

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     4500

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     4560

cctacagcgt gagcattgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     4620

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     4680

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     4740

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     4800

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     4860

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     4920

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     4980

cgcgcgttgg ccgattcatt aatgcagctg tggaatgtgt gtcagttagg gtgtggaaag     5040

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     5100

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5160

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     5220

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     5280

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     5340

tgcaaaaagc ttggacacaa gacaggcttg cgagatatgt ttgagaatac cactttatcc     5400

cgcgtcaggg agaggcagtg cgtaaaaaga cgcggactca tgtgaaatac tggtttttag     5460

tgcgccagat ctctataatc tcgcgcaacc tattttcccc tcgaacactt tttaagccgt     5520

agataaacag gctgggacac ttcacatgag cgaaaaatac atcgtcacct gggacatgtt     5580

gcagatccat gcacgtaaac tcgcaagccg actgatgcct tctgaacaat ggaaaggcat     5640

tattgccgta agccgtggcg gtctgtaccg ggtgcgttac tggcgcgtga actgggtatt     5700

cgtcatgtcg ataccgtttg tatttccagc tacgatcacg acaaccagcg cgagcttaaa     5760

gtgctgaaac gcgcagaagg cgatggcgaa ggcttcatcg ttattgatga cctggtggat     5820

accggtggta ctgcggttgc gattcgtgaa atgtatccaa aagcgcactt tgtcaccatc     5880

ttcgcaaaac cggctggtcg tccgctggtt gatgactatg ttgttgatat cccgcaagat     5940

acctggattg aacagccgtg ggatatgggc gtcgtattcg tcccgccaat ctccggtcgc     6000

taatcttttc aacgcctggc actgccgggc gttgttcttt ttaacttcag gcgggttaca     6060

atagtttcca gtaagtattc tggaggctgc atccatgaca caggcaaacc tgagcgaaac     6120

cctgttcaaa ccccgcttta aacatcctga aacctcgacg ctagtccgcc gctttaatca     6180

cggcgcacaa ccgcctgtgc agtcggccct tgatggtaaa accatccctc actggtatcg     6240

catgattaac cgtctgatgt ggatctggcg cggcattgac ccacgcgaaa tcctcgacgt     6300

ccaggcacgt attgtgatga gcgatgccga acgtaccgac gatgatttat acgatacggt     6360

gattggctac cgtggcggca actggattta tgagtgggcc ccggatcttt gtgaaggaac     6420

cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg     6480

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat     6540

tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg     6600

aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc     6660

aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag     6720

aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta     6780

tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg     6840

taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac     6900

acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt     6960

taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata     7020

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     7080

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     7140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     7200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcaactgg     7260

ataactcaag ctaaccaaaa tcatcccaaa cttcccaccc cataccctat taccactgcc     7320

aattacctag tggtttcatt tactctaaac ctgtgattcc tctgaattat tttcatttta     7380

aagaaattgt atttgttaaa tatgtactac aaacttagta gttggaaggg ctaattcact     7440

cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc tacttccctg     7500

attagcagaa ctacacacca gggccagggg tcagatatcc actgaccttt ggatggtgct     7560

acaagctagt accagttgag ccagataagg tagaagaggc caataaagga gagaacacca     7620

gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtgttagagt     7680

ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat ccggagtact     7740

tcaagaactg ctgatatcga gcttgctaca agggactttc cgctggggac tttccaggga     7800

ggcgtggcct gggcgggact ggggagtggc gagccctcag atcctgcata taagcagctg     7860

ctttttgcct gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc     7920

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     7980

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     8040

tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg     8100

agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc     8160

gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg     8220

agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc     8280

cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac     8340

gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac     8400

agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag     8460

caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca     8520

agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc     8580

agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta     8640

gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga     8700

gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc     8760

actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata     8820

gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc     8880

acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag     8940

gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg     9000

ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg     9060

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     9120

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     9180

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     9240

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     9300

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     9360

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     9420

gtgaacggat ctcgacggta tcgccgaatt cacaaatggc agtattcatc cacaatttta     9480

aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa     9540

cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt     9600

attacaggga cagcagagat ccactttggc tgatacgcgg atctacgcgt attaatagta     9660

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     9720

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     9780

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     9840

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     9900

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     9960

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt    10020

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca    10080

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg    10140

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta    10200

tataagcaga gctggtttag tgaaccgtca gatccgatca caagtttgta caaaaaagca    10260

ggctccttaa acatatgtgc cgccaccatg gcatcctccc cgccgaaaaa gaaaagaaag    10320

gtcagctgga aggacgcaag cggatggagc cgcatgcacg ccgatccgat ccgaccgcgg    10380

cggcccagcc ctgccaggga acttcttccg ggaccgcagc ctgacagagt gcaacccacg    10440

gccgataggg gagtgtcggc gcctgcgggc agccctttgg atggtctgcc cgcgaggcgg    10500

acagtctcgc gcactagatt gccttcaccc ccggcgccct cgcctgcgtt ttcggccgga    10560

tcgtttagcg atctgctcag acccttcgat cctagccttc tcgacacctc gcttttggat    10620

tcaatgcctg ctgtcggaac accccatacc gcagcggcac ccgctgaatg ggatgaggcg    10680

cagtcggcac tcagagcggc cgacgatcct ccaccgaccg tacgcgtcgc agtgactgca    10740

gccaggccgc caagagccaa acccgcgccg cgccgacggg ctgcccagcc gtcggatgcg    10800

tcgcccgcag cgcaagtcga ccttaggacc ctggggtata gccaacagca gcaggagaaa    10860

atcaagccaa aagtgaggtc gacagtcgcc cagcatcacg aagccctcgt cgggcatggg    10920

tttacacacg cacatatcgt ggccttgtcc caacacccgg cggcgcttgg tactgtggcc    10980

gtaacgtacc agcacatcat taccgcactc ccggaagcca cgcacgagga catcgtcggg    11040

gtgggcaaac agtggagcgg ggcacgcgct ttggaggccc tcctcacgga tgcgggagaa    11100

ttgagaggac cgccgctcca gttggacacg ggacagttgg tgaagatcgc taagcgggga    11160

ggtgtcacag ccatggaagc ggtgcacgcg tcccggaatg ccttgacggg agcaccgctt    11220

aatctgaccc cggctcaagt agtcgcgatc gcttcaaaca tcggaggaaa gcaggcgctc    11280

gaaacagtac agcgcttgct ccctgtgttg tgccaggatc atggactgac accagaccag    11340

gtagtggcga ttgcttcgca cgatgggggc aaacaggccc ttgagacggt acagcggttg    11400

ttgcccgtac tttgccagga ccatgggctg acacccgatc aagtggtggc aattgccagc    11460

aacattggag gtaaacaagc gctcgaaacg gtacagagac tccttcccgt gttgtgccag    11520

gatcacggac tgacccccga ccaggtggtc gcgatcgcgt cacatgatgg agggaaacaa    11580

gcgttggaaa cagtccagag actcctgcca gtcctttgcc aagatcatgg tctgacgccc    11640

gaccaggtgg tggccatcgc ttcgaatatc ggagggaagc aggcactcga gacggtccag    11700

aggttgttgc cggtactctg tcaagaccat gggcttacac ctgaccaggt cgtggccatt    11760

gcgagcaacg gtgggggaaa gcaagcactt gaaaccgtgc agagactgct cccggtgctg    11820

tgtcaagacc atggcctcac cccagatcag gtagtcgcca ttgcatccaa caacgggggt    11880

aagcaggcct tggaaacggt gcaaaggttg ctccccgtac tgtgccaaga tcatgggttg    11940

acgccagacc aggtcgtggc aatcgcctcc aacattgggg gcaagcaagc gctggaaact    12000

gtgcagaggc tgttgcctgt cctctgccag gatcatgggc tcacgcccga tcaggtagtc    12060

gccatcgcat ccaatatcgg tgggaagcaa gcccttgaga ctgtccagcg gttgctgccc    12120

gtgctttgcc aagaccacgg gttgactccc gatcaagtag tagcgattgc ctcaaataat    12180

gggggtaaac aagcgctgga gacagtccag agacttcttc ccgtgctttg ccaggatcat    12240

ggattgaccc ctgatcaagt agtggccatc gcctcaaacg ggggaggaaa gcaggcattg    12300

gagacggtgc agagattgct gcctgtgctt tgtcaggacc acggacttac accggatcag    12360

gtcgtcgcga ttgcaagcaa tgggggtggt aaacaggcac tggagaccgt gcagcgactt    12420

ctcccagtgt tgtgtcaaga tcacggtctg actcctgacc aagtcgtggc gattgcgtcc    12480

aataacgggg gaaaacaggc gcttgaaacg gtgcagcggc tcctcccggt gctttgtcaa    12540

gatcacgggc tcacaccgga ccaggtagtg gctatcgcat cgaacggggg aggaaaacag    12600

gcgcttgaga cagtacagag gcttctgccc gtgctgtgcc aagaccacgg gcttacgccg    12660

gatcaagtgg tggccatcgc ttcgaatatt ggtggcaaac aggccctcga gacagtgcaa    12720

cggcttttgc ctgtactgtg tcaggatcac ggcctcactc ctgaccaggt ggtcgctatt    12780

gcgtcgaata acggtgggaa acaggcattg gagacggtgc agcggctcct gccggtcctc    12840

tgtcaggacc acggactcac tccggatcaa gtcgtagcca ttgcgtcgaa cggaggagga    12900

aagcaggcgc tcgaatcaat cgtcgcgcag ctctcacgaa gagaccctgc tctcgccgcg    12960

ttgaccaacg atcacttggt ggccttggca tgccttggtg gacgacccgc attggacgcg    13020

gtaaagaagg gcctccccca tgcgccagag ttcatccgac gcgtgaatcg ccggattgcg    13080

gagcgaacct cccaccgcgt agctgactac gcacacgtgg tcagagtcct tgagtttttc    13140

cagtgccact cccatcccgc ccacgcgttc gacgaggcga tgactcagtt tggtatgtcg    13200

cgacatgggc tggtgcagct cttccgacga gtcggggtga ccgagttcga ggccagatac    13260

gggactttgc ctcccgcctc acagcgctgg gaccgcatct tgcaggccag cggcatgaaa    13320

agggcgaagc cgagccccac gtcggctcaa acgcctgacc agacctcgct tcacgccttt    13380

gcggactccc tggagcgcga ccttgacgca cccagcccaa tgcatgaggg agatcaaact    13440

cgggcgtcgt cgcggaaaag atcgagatcg gacagggccg tgacaggacc gtcggcccag    13500

caggcagtgg aggtcagggt acccgagcag agggacgcgc ttcacctccc cctttcatgg    13560

cgagtcaagc gacctcggac tagaatctgg ggagggttgc cagatccgat ctcaaggtcg    13620

cagctggtga agtcggaact ggaggaaaag aagtccgagc ttcgccacaa gctcaagtat    13680

gtcccccacg aatacattga acttatcgaa atcgcaagaa acagcaccca ggacaggatt    13740

ttggagatga aggtcatgga gttcttcatg aaggtatatg gttatagggg gaagcatctc    13800

ggaggatcgc gaaagccaga cggagcgatc tacacagtgg gatcacccat cgattacggg    13860

gtgatcgtcg acaccaaggc gtacagcgga ggttataatc tgcccatcgg gcaggcagat    13920

gaaatggaac gctatgtgga agaaaatcag acccgcaaca aacacctgaa tcccaacgag    13980

tggtggaaag tatacccctc atcagtaacg gagtttaagt tccttttcgt atccggacac    14040

ttcaagggaa actacaaggc tcagctcact agactgaacc atattactaa ctgcaacggg    14100

gcggtcctgt ccgtcgaaga gctgctcatc ggtggggaaa tgattaaggc gggaacactc    14160

acgttggagg aggtacgccg caaattcaat aacggtgaga ttaacttctg aggcgcctcg    14220

agccgaccca gctttc                                                    14236


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 wild type target site

<400>  72
caccatccac tacaacttca tgtgcaacag                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone A9) mutated through NHEJ

<400>  73
caccatccac tacagcttca tgtgcaacag                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone H4) mutated through NHEJ

<400>  74
caccatccac tacaacctca tgtgcaacag                                        30


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone A3) mutated through NHEJ

<400>  75
caccatccac tacaacttca tgtgcgacag                                        30


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone B4) mutated through NHEJ

<400>  76
caccatccac tacaacttcg tgtgcaacag                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone C3) mutated through NHEJ

<400>  77
caccatccac tacaacttca tatgcaacag                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone F6) mutated through NHEJ

<400>  78
caccatccac tacaacttca tgtgcgacag                                        30


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone G2) mutated through NHEJ

<400>  79
cactatccac tacaacttca tgtgcaacag                                        30


<210>  80
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone H12) mutated through NHEJ

<400>  80
caccgtccac tacaacttca tgtgcaacag                                        30


<210>  81
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 wild type target site


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  y= C or T

<400>  81
cgtcccccag gtcggctctg actgtaccac catccactac aacttcatgt gy               52


<210>  82
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone A7) mutated through NHEJ

<400>  82
cgtcccccag gtcggctctg actgcaccac catccactac aacttcatgt gc               52


<210>  83
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone B9) mutated through NHEJ

<400>  83
cgtcccccag gtcggctctg actgtaccac cgtccactac aacttcatgt gc               52


<210>  84
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone E1) mutated through NHEJ

<400>  84
cgtcccccag gtcggctctg actgtaccat catccactac aacttcatgt gc               52


<210>  85
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone H4) mutated through NHEJ

<400>  85
cgtcccccag gtcggctctg accgtaccac catccactac aacttcatgt gc               52


<210>  86
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone A8) mutated through NHEJ

<400>  86
cgtcccccag gtcggctctg actgtaccac catccactac aacctcatgt gc               52


<210>  87
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone D8) mutated through NHEJ

<400>  87
cgtcccccag gtcggctctg actgtaccac catccactac aacctcatgt gc               52


<210>  88
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone F11) mutated through NHEJ

<400>  88
cgtcccccag gtcggctctg actgtaccac catccactac aacttcgtgt gc               52


<210>  89
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone E1) mutated through NHEJ

<400>  89
cgtcccccag gttggctctg actgtaccac catccactac aacttcatgt gc               52


<210>  90
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone F2) mutated through NHEJ

<400>  90
cgttccccag gtcggctctg actgtaccac catccactac aacttcatgt gc               52


<210>  91
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone F5) mutated through NHEJ

<400>  91
cgtcctccag gtcggctctg actgtaccac catccactac aacttcatgt gc               52


<210>  92
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site (clone F6) mutated through NHEJ

<400>  92
cgtcccccag gtaggctctg actgtaccac catccactac aacttcatgt gc               52


<210>  93
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 wild type target site

<400>  93
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  94
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 1 mutated through NHEJ

<400>  94
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgcgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  95
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 2 mutated through NHEJ

<400>  95
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgccgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  96
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 3 mutated through NHEJ

<400>  96
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcagc      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  97
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 4 mutated through NHEJ

<400>  97
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg ctcatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  98
<211>  497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 5 mutated through NHEJ

<400>  98
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcacact ggaagatgcc      240

aggtaggggc cgcacgccgc cctccacgct ggcgggcccc tcctcagcct ctgccagtct      300

ccatggccct gccgctcatc cccttctccc gggcttccag ccatccttcc ctctggctgc      360

agccactttg cgtccctctg ctgctccctc ccagtgccct tttccccggc tttggcaccc      420

ctcttacctg tggcttcttg atcagctgga gctgaggctc ctcgtaggat gcgggggatg      480

gggagggggt ggggccc                                                     497


<210>  99
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 6 mutated through NHEJ

<400>  99
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccagatcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  100
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 7 mutated through NHEJ

<400>  100
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgaatgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  101
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 8 mutated through NHEJ

<400>  101
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctccggca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  102
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p53 target site 9 mutated through NHEJ

<400>  102
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat aaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  103
<211>  599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wild type GFP sequence

<400>  103
tttacttgta cagctcgtcc atgccgacag tgcaaccgaa aggcggtcac gaactccagc       60

aggaccatgt gatccttctt ttcgttgggg tctttgctca gggcggactg ggtgctcagg      120

tagtggttgt cgggcagcag cacggggccg tcgccgatgg gggtgttctg ctggtagtgg      180

tcggcgagct gcacgctgcc gtcctcgatg ttgtggcgga tcttgaagtt caccttgatg      240

ccgttcttct gcttgtcggc catgatatag acgttgtggc tgttgtagtt gtactccagc      300

ttgtgcccca ggatgttgcc gtcctccttg aagtcaatgc ccttcagctc gatgcggttc      360

accagggtgt cgccctcgaa cttcacctcg gcgcgggtct tgtaattgcc gtcgtccttg      420

aagaagatgg tgcgctcctg gacgtagcct tcgggaatgg cggacttgaa gaagtcgtgc      480

tgcttcatgt ggtcggggta gcggctgaaa cactgcacgc cgtatgtcat ggtggtcacg      540

agggtgggcc agggcacggg cagcttgccg gtggtgcaga tgaacttcag ggtcagctt       599


<210>  104
<211>  445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP sequence mutated through NHEJ

<400>  104
tttacttgta cagctcgtcc atgccgagag tgatcccggc ggcggtcacg aactccagca       60

ggaccatgtg atcgcgcttc tcgttggggt ctttgctcag ggcggactgg gtgctcaggt      120

agtggttgtc gggcagcagc acggggccgt cgccgatggg ggtgttctgc tggtagtggt      180

cggcgagctg cacgctgccg tcctcgatgt tgtggcggat cttgaagttc accttgatgc      240

cgttcttctg cttgtcggcc atgatataga agatggtgcg ctcctggacg tagccttcgg      300

gcatggcgga cttgaagaag tcgtgctgct tcatgtggtc gggatagcgg ctgaagcact      360

gcacgccgta ggtcagggtg gtcacgaggg tgggccaggg cacgggcagc ttgccggtgg      420

tgcagatgaa cttcagggtc agctt                                            445


<210>  105
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALEN1 DNA recognition site

<400>  105
cgtcccccag gtcggctct                                                    19


<210>  106
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALEN2 DNA recognition site

<400>  106
acacatgaag ttgtagt                                                      17


<210>  107
<211>  16
<212>  DNA
<213>  Sus scrofa

<400>  107
gactgtacca ccatcc                                                       16


<210>  108
<211>  500
<212>  DNA
<213>  Sus srofa

<400>  108
cttctcactt gacctgccgc agcctcgtga ggcgggtaga gcagatgggt tacccccatt       60

ccacagctga ggcgcccaga ggccagtggc ctgccggggc tagtagggtc accttgggcc      120

tgtgtcgtcc cccaggtcgg ctctgactgt accaccatcc actacaactt catgtgcaac      180

agctcctgca tggggggcat gaaccggcgg cccatcctca ccatcatcac actggaagat      240

gccaggtagg ggccgcacgc cgccctccac gctggcgggc ccctcctcag cctctgccag      300

tctccatggc cctgccgctc atccccttct cccgggcttc cagccatcct tccctctggc      360

tgcagccact ttgcgtccct ctgctgctcc ctcccagtgc ccttttcccc ggctttggca      420

cccctcttac ctgtggcttc ttgatcagct ggagctgagg ctcctcgtag gatgcggggg      480

atggggaggg ggtggggccc                                                  500


<210>  109
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE1 nucleic sequence

<400>  109
atggcatcct ccccgccgaa aaagaaaaga aaggtcagct ggaaggacgc aagcggatgg       60

agccgcatgc acgccgatcc gatccgaccg cggcggccca gccctgccag ggaacttctt      120

ccgggaccgc agcctgacag agtgcaaccc acggccgata ggggagtgtc ggcgcctgcg      180

ggcagccctt tggatggtct gcccgcgagg cggacagtct cgcgcactag attgccttca      240

cccccggcgc cctcgcctgc gttttcggcc ggatcgttta gcgatctgct cagacccttc      300

gatcctagcc ttctcgacac ctcgcttttg gattcaatgc ctgctgtcgg aacaccccat      360

accgcagcgg cacccgctga atgggatgag gcgcagtcgg cactcagagc ggccgacgat      420

cctccaccga ccgtacgcgt cgcagtgact gcagccaggc cgccaagagc caaacccgcg      480

ccgcgccgac gggctgccca gccgtcggat gcgtcgcccg cagcgcaagt cgaccttagg      540

accctggggt atagccaaca gcagcaggag aaaatcaagc caaaagtgag gtcgacagtc      600

gcccagcatc acgaagccct cgtcgggcat gggtttacac acgcacatat cgtggccttg      660

tcccaacacc cggcggcgct tggtactgtg gccgtaacgt accagcacat cattaccgca      720

ctcccggaag ccacgcacga ggacatcgtc ggggtgggca aacagtggag cggggcacgc      780

gctttggagg ccctcctcac ggatgcggga gaattgagag gaccgccgct ccagttggac      840

acgggacagt tggtgaagat cgctaagcgg ggaggtgtca cagccatgga agcggtgcac      900

gcgtcccgga atgccttgac gggagcaccg cttaatctta caccagcgca ggtcgtcgcg      960

atcgcatccc atgatggtgg taaacaagcg ttggaaaccg tgcagcggtt gctgcccgta     1020

ctgtgccaag atcacgggct gacacccgac caagtagtag cgatcgcgtc caataacgga     1080

gggaaacagg cactcgagac ggtgcaacga ctgctgcctg tgctctgcca agaccacgga     1140

ctgacaccgg atcaagtggt ggcaattgca tcgaacggag ggggaaaaca ggcccttgag     1200

actgtacaaa gactcctgcc ggtgttgtgc caggaccatg gactgactcc tgatcaggta     1260

gtggctattg caagccacga tgggggaaaa caagcgctcg aaacggtgca gcgcctcctt     1320

cccgtcctct gccaagatca cggtttgacg ccagatcagg tagtcgcgat tgcatcgcac     1380

gatggaggaa aacaggcttt ggagacggta cagagattgc ttcctgtatt gtgtcaagac     1440

catgggctca cgccggacca ggtggtggcc atcgcgagcc acgacggagg taagcaggct     1500

ttggagactg tgcagcggct tctccccgtc ttgtgccaag accacgggct cacacctgac     1560

caggtggtcg ccatcgcatc acacgatggc gggaaacaag ctctggagac agtccagaga     1620

ctcctcccgg tcctttgcca ggatcacgga cttacgcccg atcaggtcgt agctatcgcc     1680

tcccatgacg ggggcaagca ggcgttggaa acagtccaga ggttgcttcc cgtactgtgc     1740

caggatcacg ggttgacgcc ggatcaggtc gtggcgatcg cgtccaacat tggtggaaag     1800

caagcgctcg aaacagtgca gaggttgttg cccgtgcttt gtcaagacca cggtctgact     1860

ccggatcaag tagtcgccat tgcgtcaaac aacggcggga agcaggcact tgaaacagta     1920

caacgcttgc tgccggtact ttgccaggac catgggttga cgccggatca ggtagtggca     1980

atcgcctcaa acaacggcgg gaagcaggct ctggaaactg tccaacgact tctccctgtg     2040

ctgtgtcagg accatggact cacgcccgac caagtagtgg cgattgcgtc gaacgggggt     2100

ggcaaacagg cgctcgagac agtccagcgg ctgcttccag tcctgtgtca ggatcatggg     2160

ctgactccag accaagtggt ggcgatcgcc tcacacgacg ggggaaagca agctcttgag     2220

acggtccaga gattgctgcc agtcttgtgt caagatcacg gactgactcc cgatcaggta     2280

gtagcgattg cctccaataa tggtggtaag caagcccttg aaacggtcca aagactcctt     2340

cctgtacttt gtcaggatca cggtctgacg cccgatcaag tcgtagcaat tgcgtcgaat     2400

aatggaggta aacaggcgct cgaaaccgtc caaagactgc tccccgtgct gtgtcaggac     2460

catggcctta cgcccgacca ggtcgtcgca atcgcttcgc acgacggcgg aaaacaagcc     2520

cttgaaacgg tccagcgcct cctcccggtc ctttgtcagg atcatggtct tacgccggac     2580

caggtggtgg ctatcgccag caatggagga ggaaagcagg cattggaaac ggtgcagagg     2640

cttcttccgg tgctctgtca ggaccacggc cttacgcctg atcaagtagt cgccatcgcg     2700

tcgcatgacg gaggaaaaca agccttggaa acagtccaaa ggctgctccc cgtcctctgt     2760

caggatcacg gtctgacccc agaccaggtc gtcgcaattg cttccaatgg tgggggaaag     2820

caagcattgg agtcaatcgt cgcgcagctc tcacgaagag accctgctct cgccgcgttg     2880

accaacgatc acttggtggc cttggcatgc cttggtggac gacccgcatt ggacgcggta     2940

aagaagggcc tcccccatgc gccagagttc atccgacgcg tgaatcgccg gattgcggag     3000

cgaacctccc accgcgtagc tgactacgca cacgtggtca gagtccttga gtttttccag     3060

tgccactccc atcccgccca cgcgttcgac gaggcgatga ctcagtttgg tatgtcgcga     3120

catgggctgg tgcagctctt ccgacgagtc ggggtgaccg agttcgaggc cagatacggg     3180

actttgcctc ccgcctcaca gcgctgggac cgcatcttgc aggccagcgg catgaaaagg     3240

gcgaagccga gccccacgtc ggctcaaacg cctgaccaga cctcgcttca cgcctttgcg     3300

gactccctgg agcgcgacct tgacgcaccc agcccaatgc atgagggaga tcaaactcgg     3360

gcgtcgtcgc ggaaaagatc gagatcggac agggccgtga caggaccgtc ggcccagcag     3420

gcagtggagg tcagggtacc cgagcagagg gacgcgcttc acctccccct ttcatggcga     3480

gtcaagcgac ctcggactag aatctgggga gggttgccag atccgatctc aaggtcgcag     3540


<210>  110
<211>  3336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE2 nucleic sequence

<400>  110
atggcatcct ccccgccgaa aaagaaaaga aaggtcagct ggaaggacgc aagcggatgg       60

agccgcatgc acgccgatcc gatccgaccg cggcggccca gccctgccag ggaacttctt      120

ccgggaccgc agcctgacag agtgcaaccc acggccgata ggggagtgtc ggcgcctgcg      180

ggcagccctt tggatggtct gcccgcgagg cggacagtct cgcgcactag attgccttca      240

cccccggcgc cctcgcctgc gttttcggcc ggatcgttta gcgatctgct cagacccttc      300

gatcctagcc ttctcgacac ctcgcttttg gattcaatgc ctgctgtcgg aacaccccat      360

accgcagcgg cacccgctga atgggatgag gcgcagtcgg cactcagagc ggccgacgat      420

cctccaccga ccgtacgcgt cgcagtgact gcagccaggc cgccaagagc caaacccgcg      480

ccgcgccgac gggctgccca gccgtcggat gcgtcgcccg cagcgcaagt cgaccttagg      540

accctggggt atagccaaca gcagcaggag aaaatcaagc caaaagtgag gtcgacagtc      600

gcccagcatc acgaagccct cgtcgggcat gggtttacac acgcacatat cgtggccttg      660

tcccaacacc cggcggcgct tggtactgtg gccgtaacgt accagcacat cattaccgca      720

ctcccggaag ccacgcacga ggacatcgtc ggggtgggca aacagtggag cggggcacgc      780

gctttggagg ccctcctcac ggatgcggga gaattgagag gaccgccgct ccagttggac      840

acgggacagt tggtgaagat cgctaagcgg ggaggtgtca cagccatgga agcggtgcac      900

gcgtcccgga atgccttgac gggagcaccg cttaatctga ccccggctca agtagtcgcg      960

atcgcttcaa acatcggagg aaagcaggcg ctcgaaacag tacagcgctt gctccctgtg     1020

ttgtgccagg atcatggact gacaccagac caggtagtgg cgattgcttc gcacgatggg     1080

ggcaaacagg cccttgagac ggtacagcgg ttgttgcccg tactttgcca ggaccatggg     1140

ctgacacccg atcaagtggt ggcaattgcc agcaacattg gaggtaaaca agcgctcgaa     1200

acggtacaga gactccttcc cgtgttgtgc caggatcacg gactgacccc cgaccaggtg     1260

gtcgcgatcg cgtcacatga tggagggaaa caagcgttgg aaacagtcca gagactcctg     1320

ccagtccttt gccaagatca tggtctgacg cccgaccagg tggtggccat cgcttcgaat     1380

atcggaggga agcaggcact cgagacggtc cagaggttgt tgccggtact ctgtcaagac     1440

catgggctta cacctgacca ggtcgtggcc attgcgagca acggtggggg aaagcaagca     1500

cttgaaaccg tgcagagact gctcccggtg ctgtgtcaag accatggcct caccccagat     1560

caggtagtcg ccattgcatc caacaacggg ggtaagcagg ccttggaaac ggtgcaaagg     1620

ttgctccccg tactgtgcca agatcatggg ttgacgccag accaggtcgt ggcaatcgcc     1680

tccaacattg ggggcaagca agcgctggaa actgtgcaga ggctgttgcc tgtcctctgc     1740

caggatcatg ggctcacgcc cgatcaggta gtcgccatcg catccaatat cggtgggaag     1800

caagcccttg agactgtcca gcggttgctg cccgtgcttt gccaagacca cgggttgact     1860

cccgatcaag tagtagcgat tgcctcaaat aatgggggta aacaagcgct ggagacagtc     1920

cagagacttc ttcccgtgct ttgccaggat catggattga cccctgatca agtagtggcc     1980

atcgcctcaa acgggggagg aaagcaggca ttggagacgg tgcagagatt gctgcctgtg     2040

ctttgtcagg accacggact tacaccggat caggtcgtcg cgattgcaag caatgggggt     2100

ggtaaacagg cactggagac cgtgcagcga cttctcccag tgttgtgtca agatcacggt     2160

ctgactcctg accaagtcgt ggcgattgcg tccaataacg ggggaaaaca ggcgcttgaa     2220

acggtgcagc ggctcctccc ggtgctttgt caagatcacg ggctcacacc ggaccaggta     2280

gtggctatcg catcgaacgg gggaggaaaa caggcgcttg agacagtaca gaggcttctg     2340

cccgtgctgt gccaagacca cgggcttacg ccggatcaag tggtggccat cgcttcgaat     2400

attggtggca aacaggccct cgagacagtg caacggcttt tgcctgtact gtgtcaggat     2460

cacggcctca ctcctgacca ggtggtcgct attgcgtcga ataacggtgg gaaacaggca     2520

ttggagacgg tgcagcggct cctgccggtc ctctgtcagg accacggact cactccggat     2580

caagtcgtag ccattgcgtc gaacggagga ggaaagcagg cgctcgaatc aatcgtcgcg     2640

cagctctcac gaagagaccc tgctctcgcc gcgttgacca acgatcactt ggtggccttg     2700

gcatgccttg gtggacgacc cgcattggac gcggtaaaga agggcctccc ccatgcgcca     2760

gagttcatcc gacgcgtgaa tcgccggatt gcggagcgaa cctcccaccg cgtagctgac     2820

tacgcacacg tggtcagagt ccttgagttt ttccagtgcc actcccatcc cgcccacgcg     2880

ttcgacgagg cgatgactca gtttggtatg tcgcgacatg ggctggtgca gctcttccga     2940

cgagtcgggg tgaccgagtt cgaggccaga tacgggactt tgcctcccgc ctcacagcgc     3000

tgggaccgca tcttgcaggc cagcggcatg aaaagggcga agccgagccc cacgtcggct     3060

caaacgcctg accagacctc gcttcacgcc tttgcggact ccctggagcg cgaccttgac     3120

gcacccagcc caatgcatga gggagatcaa actcgggcgt cgtcgcggaa aagatcgaga     3180

tcggacaggg ccgtgacagg accgtcggcc cagcaggcag tggaggtcag ggtacccgag     3240

cagagggacg cgcttcacct ccccctttca tggcgagtca agcgacctcg gactagaatc     3300

tggggagggt tgccagatcc gatctcaagg tcgcag                               3336


<210>  111
<211>  1375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN1 amino acid sequence

<400>  111

Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
1               5                   10                  15      


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
            100                 105                 110         


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
        115                 120                 125             


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
    130                 135                 140                 


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Ala Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
                405                 410                 415     


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
        435                 440                 445             


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
465                 470                 475                 480 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His 
        515                 520                 525             


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
        675                 680                 685             


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
705                 710                 715                 720 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            740                 745                 750         


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        835                 840                 845             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    850                 855                 860                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
865                 870                 875                 880 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                885                 890                 895     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            900                 905                 910         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        915                 920                 925             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    930                 935                 940                 


Ser Ile Val Ala Gln Leu Ser Arg Arg Asp Pro Ala Leu Ala Ala Leu 
945                 950                 955                 960 


Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala 
                965                 970                 975     


Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Phe Ile Arg 
            980                 985                 990         


Arg Val Asn Arg Arg Ile Ala Glu  Arg Thr Ser His Arg  Val Ala Asp 
        995                 1000                 1005             


Tyr Ala  His Val Val Arg Val  Leu Glu Phe Phe Gln  Cys His Ser 
    1010                 1015                 1020             


His Pro  Ala His Ala Phe Asp  Glu Ala Met Thr Gln  Phe Gly Met 
    1025                 1030                 1035             


Ser Arg  His Gly Leu Val Gln  Leu Phe Arg Arg Val  Gly Val Thr 
    1040                 1045                 1050             


Glu Phe  Glu Ala Arg Tyr Gly  Thr Leu Pro Pro Ala  Ser Gln Arg 
    1055                 1060                 1065             


Trp Asp  Arg Ile Leu Gln Ala  Ser Gly Met Lys Arg  Ala Lys Pro 
    1070                 1075                 1080             


Ser Pro  Thr Ser Ala Gln Thr  Pro Asp Gln Thr Ser  Leu His Ala 
    1085                 1090                 1095             


Phe Ala  Asp Ser Leu Glu Arg  Asp Leu Asp Ala Pro  Ser Pro Met 
    1100                 1105                 1110             


His Glu  Gly Asp Gln Thr Arg  Ala Ser Ser Arg Lys  Arg Ser Arg 
    1115                 1120                 1125             


Ser Asp  Arg Ala Val Thr Gly  Pro Ser Ala Gln Gln  Ala Val Glu 
    1130                 1135                 1140             


Val Arg  Val Pro Glu Gln Arg  Asp Ala Leu His Leu  Pro Leu Ser 
    1145                 1150                 1155             


Trp Arg  Val Lys Arg Pro Arg  Thr Arg Ile Trp Gly  Gly Leu Pro 
    1160                 1165                 1170             


Asp Pro  Ile Ser Arg Ser Gln  Leu Val Lys Ser Glu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Lys  Ser Glu Leu Arg His  Lys Leu Lys Tyr Val  Pro His Glu 
    1190                 1195                 1200             


Tyr Ile  Glu Leu Ile Glu Ile  Ala Arg Asn Ser Thr  Gln Asp Arg 
    1205                 1210                 1215             


Ile Leu  Glu Met Lys Val Met  Glu Phe Phe Met Lys  Val Tyr Gly 
    1220                 1225                 1230             


Tyr Arg  Gly Lys His Leu Gly  Gly Ser Arg Lys Pro  Asp Gly Ala 
    1235                 1240                 1245             


Ile Tyr  Thr Val Gly Ser Pro  Ile Asp Tyr Gly Val  Ile Val Asp 
    1250                 1255                 1260             


Thr Lys  Ala Tyr Ser Gly Gly  Tyr Asn Leu Pro Ile  Gly Gln Ala 
    1265                 1270                 1275             


Asp Glu  Met Gln Arg Tyr Val  Lys Glu Asn Gln Thr  Arg Asn Lys 
    1280                 1285                 1290             


His Ile  Asn Pro Asn Glu Trp  Trp Lys Val Tyr Pro  Ser Ser Val 
    1295                 1300                 1305             


Thr Glu  Phe Lys Phe Leu Phe  Val Ser Gly His Phe  Lys Gly Asn 
    1310                 1315                 1320             


Tyr Lys  Ala Gln Leu Thr Arg  Leu Asn His Lys Thr  Asn Cys Asn 
    1325                 1330                 1335             


Gly Ala  Val Leu Ser Val Glu  Glu Leu Leu Ile Gly  Gly Glu Met 
    1340                 1345                 1350             


Ile Lys  Ala Gly Thr Leu Thr  Leu Glu Glu Val Arg  Arg Lys Phe 
    1355                 1360                 1365             


Asn Asn  Gly Glu Ile Asn Phe  
    1370                 1375 


<210>  112
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN2 amino acid sequence

<400>  112

Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
1               5                   10                  15      


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
            100                 105                 110         


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
        115                 120                 125             


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
    130                 135                 140                 


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Ala Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
                405                 410                 415     


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
        435                 440                 445             


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
465                 470                 475                 480 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
        675                 680                 685             


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
705                 710                 715                 720 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            740                 745                 750         


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        835                 840                 845             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    850                 855                 860                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
865                 870                 875                 880 


Gln Leu Ser Arg Arg Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
                885                 890                 895     


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val 
            900                 905                 910         


Lys Lys Gly Leu Pro His Ala Pro Glu Phe Ile Arg Arg Val Asn Arg 
        915                 920                 925             


Arg Ile Ala Glu Arg Thr Ser His Arg Val Ala Asp Tyr Ala His Val 
    930                 935                 940                 


Val Arg Val Leu Glu Phe Phe Gln Cys His Ser His Pro Ala His Ala 
945                 950                 955                 960 


Phe Asp Glu Ala Met Thr Gln Phe Gly Met Ser Arg His Gly Leu Val 
                965                 970                 975     


Gln Leu Phe Arg Arg Val Gly Val Thr Glu Phe Glu Ala Arg Tyr Gly 
            980                 985                 990         


Thr Leu Pro Pro Ala Ser Gln Arg  Trp Asp Arg Ile Leu  Gln Ala Ser 
        995                 1000                 1005             


Gly Met  Lys Arg Ala Lys Pro  Ser Pro Thr Ser Ala  Gln Thr Pro 
    1010                 1015                 1020             


Asp Gln  Thr Ser Leu His Ala  Phe Ala Asp Ser Leu  Glu Arg Asp 
    1025                 1030                 1035             


Leu Asp  Ala Pro Ser Pro Met  His Glu Gly Asp Gln  Thr Arg Ala 
    1040                 1045                 1050             


Ser Ser  Arg Lys Arg Ser Arg  Ser Asp Arg Ala Val  Thr Gly Pro 
    1055                 1060                 1065             


Ser Ala  Gln Gln Ala Val Glu  Val Arg Val Pro Glu  Gln Arg Asp 
    1070                 1075                 1080             


Ala Leu  His Leu Pro Leu Ser  Trp Arg Val Lys Arg  Pro Arg Thr 
    1085                 1090                 1095             


Arg Ile  Trp Gly Gly Leu Pro  Asp Pro Ile Ser Arg  Ser Gln Leu 
    1100                 1105                 1110             


Val Lys  Ser Glu Leu Glu Glu  Lys Lys Ser Glu Leu  Arg His Lys 
    1115                 1120                 1125             


Leu Lys  Tyr Val Pro His Glu  Tyr Ile Glu Leu Ile  Glu Ile Ala 
    1130                 1135                 1140             


Arg Asn  Ser Thr Gln Asp Arg  Ile Leu Glu Met Lys  Val Met Glu 
    1145                 1150                 1155             


Phe Phe  Met Lys Val Tyr Gly  Tyr Arg Gly Lys His  Leu Gly Gly 
    1160                 1165                 1170             


Ser Arg  Lys Pro Asp Gly Ala  Ile Tyr Thr Val Gly  Ser Pro Ile 
    1175                 1180                 1185             


Asp Tyr  Gly Val Ile Val Asp  Thr Lys Ala Tyr Ser  Gly Gly Tyr 
    1190                 1195                 1200             


Asn Leu  Pro Ile Gly Gln Ala  Asp Glu Met Glu Arg  Tyr Val Glu 
    1205                 1210                 1215             


Glu Asn  Gln Thr Arg Asn Lys  His Leu Asn Pro Asn  Glu Trp Trp 
    1220                 1225                 1230             


Lys Val  Tyr Pro Ser Ser Val  Thr Glu Phe Lys Phe  Leu Phe Val 
    1235                 1240                 1245             


Ser Gly  His Phe Lys Gly Asn  Tyr Lys Ala Gln Leu  Thr Arg Leu 
    1250                 1255                 1260             


Asn His  Ile Thr Asn Cys Asn  Gly Ala Val Leu Ser  Val Glu Glu 
    1265                 1270                 1275             


Leu Leu  Ile Gly Gly Glu Met  Ile Lys Ala Gly Thr  Leu Thr Leu 
    1280                 1285                 1290             


Glu Glu  Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe 
    1295                 1300                 1305         


<210>  113
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN DNA binding domain - module 1 amino acid sequence

<400>  113

Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly 
        


<210>  114
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN DNA binding domain - module 2 amino acid sequence

<400>  114

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly 
        


<210>  115
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN DNA binding domain - module 3 amino acid sequence

<400>  115

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly 
        


<210>  116
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN DNA binding domain - module 4 amino acid sequence

<400>  116

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly 
        


<210>  117
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN DNA binding domain - module 5 amino acid sequence

<400>  117

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu 
            20  


<210>  118
<211>  54
<212>  DNA
<213>  Sus scrofa


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  y= C or T

<400>  118
tcgtccccca ggtcggctct gactgtacca ccatccacta caacttcatg tgya             54


<210>  119
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE1 amino acid sequence

<400>  119

Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
1               5                   10                  15      


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
            100                 105                 110         


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
        115                 120                 125             


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
    130                 135                 140                 


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Ala Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
                405                 410                 415     


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
        435                 440                 445             


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
465                 470                 475                 480 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His 
        515                 520                 525             


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
        675                 680                 685             


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
705                 710                 715                 720 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            740                 745                 750         


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        835                 840                 845             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    850                 855                 860                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
865                 870                 875                 880 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                885                 890                 895     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            900                 905                 910         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        915                 920                 925             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    930                 935                 940                 


Ser Ile Val Ala Gln Leu Ser Arg Arg Asp Pro Ala Leu Ala Ala Leu 
945                 950                 955                 960 


Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala 
                965                 970                 975     


Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Phe Ile Arg 
            980                 985                 990         


Arg Val Asn Arg Arg Ile Ala Glu  Arg Thr Ser His Arg  Val Ala Asp 
        995                 1000                 1005             


Tyr Ala  His Val Val Arg Val  Leu Glu Phe Phe Gln  Cys His Ser 
    1010                 1015                 1020             


His Pro  Ala His Ala Phe Asp  Glu Ala Met Thr Gln  Phe Gly Met 
    1025                 1030                 1035             


Ser Arg  His Gly Leu Val Gln  Leu Phe Arg Arg Val  Gly Val Thr 
    1040                 1045                 1050             


Glu Phe  Glu Ala Arg Tyr Gly  Thr Leu Pro Pro Ala  Ser Gln Arg 
    1055                 1060                 1065             


Trp Asp  Arg Ile Leu Gln Ala  Ser Gly Met Lys Arg  Ala Lys Pro 
    1070                 1075                 1080             


Ser Pro  Thr Ser Ala Gln Thr  Pro Asp Gln Thr Ser  Leu His Ala 
    1085                 1090                 1095             


Phe Ala  Asp Ser Leu Glu Arg  Asp Leu Asp Ala Pro  Ser Pro Met 
    1100                 1105                 1110             


His Glu  Gly Asp Gln Thr Arg  Ala Ser Ser Arg Lys  Arg Ser Arg 
    1115                 1120                 1125             


Ser Asp  Arg Ala Val Thr Gly  Pro Ser Ala Gln Gln  Ala Val Glu 
    1130                 1135                 1140             


Val Arg  Val Pro Glu Gln Arg  Asp Ala Leu His Leu  Pro Leu Ser 
    1145                 1150                 1155             


Trp Arg  Val Lys Arg Pro Arg  Thr Arg Ile Trp Gly  Gly Leu Pro 
    1160                 1165                 1170             


Asp Pro  Ile Ser Arg Ser Gln  
    1175                 1180 


<210>  120
<211>  1112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE2 amino acid sequence

<400>  120

Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
1               5                   10                  15      


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
            100                 105                 110         


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
        115                 120                 125             


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
    130                 135                 140                 


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Ala Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
                405                 410                 415     


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
        435                 440                 445             


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
465                 470                 475                 480 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
        675                 680                 685             


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
705                 710                 715                 720 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            740                 745                 750         


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        835                 840                 845             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    850                 855                 860                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
865                 870                 875                 880 


Gln Leu Ser Arg Arg Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
                885                 890                 895     


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val 
            900                 905                 910         


Lys Lys Gly Leu Pro His Ala Pro Glu Phe Ile Arg Arg Val Asn Arg 
        915                 920                 925             


Arg Ile Ala Glu Arg Thr Ser His Arg Val Ala Asp Tyr Ala His Val 
    930                 935                 940                 


Val Arg Val Leu Glu Phe Phe Gln Cys His Ser His Pro Ala His Ala 
945                 950                 955                 960 


Phe Asp Glu Ala Met Thr Gln Phe Gly Met Ser Arg His Gly Leu Val 
                965                 970                 975     


Gln Leu Phe Arg Arg Val Gly Val Thr Glu Phe Glu Ala Arg Tyr Gly 
            980                 985                 990         


Thr Leu Pro Pro Ala Ser Gln Arg  Trp Asp Arg Ile Leu  Gln Ala Ser 
        995                 1000                 1005             


Gly Met  Lys Arg Ala Lys Pro  Ser Pro Thr Ser Ala  Gln Thr Pro 
    1010                 1015                 1020             


Asp Gln  Thr Ser Leu His Ala  Phe Ala Asp Ser Leu  Glu Arg Asp 
    1025                 1030                 1035             


Leu Asp  Ala Pro Ser Pro Met  His Glu Gly Asp Gln  Thr Arg Ala 
    1040                 1045                 1050             


Ser Ser  Arg Lys Arg Ser Arg  Ser Asp Arg Ala Val  Thr Gly Pro 
    1055                 1060                 1065             


Ser Ala  Gln Gln Ala Val Glu  Val Arg Val Pro Glu  Gln Arg Asp 
    1070                 1075                 1080             


Ala Leu  His Leu Pro Leu Ser  Trp Arg Val Lys Arg  Pro Arg Thr 
    1085                 1090                 1095             


Arg Ile  Trp Gly Gly Leu Pro  Asp Pro Ile Ser Arg  Ser Gln 
    1100                 1105                 1110         


