                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       AUTOIMMUNE DISEASES

<130>  BIO11173 VITTECOQ / MC

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  2
<211>  434
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Ile Leu Arg Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Phe Met Gly Lys Gly Val Ser Gln 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Val Asn Val Val Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Ala Lys Ala Gly Tyr Thr Asp Gln Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Val Gln Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Ala Ser Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Ile Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Ser Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  3
<211>  425
<212>  PRT
<213>  Porphyromonas gingivalis

<400>  3

Met Glu Ile Ala Lys Ile Ile Gly Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Val His Leu Ala Cys Gly Ile Ile Gly 
            20                  25                  30          


Arg Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Glu Asn Glu Ala Ile 
        35                  40                  45              


Glu Leu Arg Asp Gln Asp Lys Ala Arg Tyr Cys Gly Lys Gly Val Leu 
    50                  55                  60                  


Lys Ala Val Lys Asn Val Asn Glu Val Ile Asp Pro Ala Leu Cys Gly 
65                  70                  75                  80  


Met Ser Val Leu Glu Gln Thr Ala Ile Asp Arg Lys Leu Ile Glu Leu 
                85                  90                  95      


Asp Gly Thr Lys Thr Lys Ser Asn Leu Gly Ala Asn Ala Met Leu Gly 
            100                 105                 110         


Val Ser Leu Ala Val Ala Lys Ala Ala Ala Ala Tyr Leu Asp Ile Pro 
        115                 120                 125             


Leu Tyr Arg Tyr Ile Gly Gly Ser Asn Thr Tyr Val Leu Pro Val Pro 
    130                 135                 140                 


Met Met Asn Ile Ile Asn Gly Gly Ser His Ser Asp Ala Pro Ile Ala 
145                 150                 155                 160 


Phe Gln Glu Phe Met Ile Arg Pro Val Gly Ala Cys Cys Phe Arg Glu 
                165                 170                 175     


Gly Leu Arg Met Gly Ala Glu Val Phe His Ala Leu Lys Lys Val Leu 
            180                 185                 190         


His Asp Arg Gly Leu Ser Thr Ala Val Gly Asp Glu Gly Gly Phe Ala 
        195                 200                 205             


Pro Ala Leu Asn Gly Thr Glu Asp Ala Ile Glu Ser Ile Leu Lys Ala 
    210                 215                 220                 


Val Glu Ala Ala Gly Tyr Val Pro Gly Lys Asp Ile Thr Ile Ala Met 
225                 230                 235                 240 


Asp Cys Ala Ser Ser Glu Phe Phe Lys Asp Gly Ile Tyr Asp Tyr Thr 
                245                 250                 255     


Lys Phe Glu Gly Glu Lys Gly Lys Lys Arg Ser Ile Asp Glu Gln Val 
            260                 265                 270         


Ala Tyr Leu Thr Glu Leu Val Gly Lys Tyr Pro Ile Asp Ser Ile Glu 
        275                 280                 285             


Asp Gly Met Ser Glu Asn Asp Trp Glu Gly Trp Lys Lys Leu Thr Val 
    290                 295                 300                 


Ala Leu Gly Asp Lys Val Gln Leu Val Gly Asp Asp Leu Phe Val Thr 
305                 310                 315                 320 


Asn Val Glu Phe Leu Arg Arg Gly Ile Ala Glu Lys Cys Gly Asn Ser 
                325                 330                 335     


Ile Leu Ile Lys Val Asn Gln Ile Gly Thr Leu Thr Glu Thr Leu Asn 
            340                 345                 350         


Ala Ile Glu Met Ala His Arg His Gly Phe Thr Ser Val Thr Ser His 
        355                 360                 365             


Arg Ser Gly Glu Thr Glu Asp Thr Thr Ile Ala Asp Ile Ala Val Ala 
    370                 375                 380                 


Thr Asn Ser Gly Gln Ile Lys Thr Gly Ser Leu Ser Arg Thr Asp Arg 
385                 390                 395                 400 


Met Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Pro 
                405                 410                 415     


Cys Ala Val Tyr Gly Tyr Lys Lys Val 
            420                 425 


<210>  4
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  chEP1

<400>  4

Cys Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr 
1               5                   10                  15      


Val Glu Cys 
            


<210>  5
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  cmEP1

<400>  5

Cys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val 
1               5                   10                  15      


Glu Cys 
        


<210>  6
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  cPorEP1

<400>  6

Cys Lys Ile Ile Gly Arg Glu Ile Leu Asp Ser Arg Gly Asn Pro Thr 
1               5                   10                  15      


Val Glu Cys 
            


