                         SEQUENCE LISTING

<110>  Ablynx nv
 
<120>  Method for the production of immunoglobulin single variable 
       domains

<130>  P11-010-PCT-1

<150>  US 61/484,109
<151>  2011-05-09

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  1

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  2
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  2

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Arg Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  3
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  3

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala His Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  4
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  4

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Ala Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  5
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  5

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Pro Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  6
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  6

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Glu Glu Gly Val Ser 
65                  70                  75                  80  


Leu Glu Lys Arg 
                


<210>  7
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  7

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Thr Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  8
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  8

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Ala Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  9
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  9

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Ala Gly Ile Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  10

Met Leu Ser Leu Thr Lys Leu Phe Ile Gly Ile Ile Leu Gly Ala Phe 
1               5                   10                  15      


Val Ala Ala 
            


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  11

Met Arg Ile Val Arg Ser Val Ala Ile Ala Ile Ala Cys His Cys Ile 
1               5                   10                  15      


Thr Ala Leu Ala 
            20  


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  12

Met Lys Leu Gln Leu Phe Thr Leu Thr Leu Ser Leu Met Ala Ser Ser 
1               5                   10                  15      


Thr Leu Ala 
            


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  13

Met Trp Ile Leu Trp Leu Leu Thr Thr Val Ser Ala 
1               5                   10          


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  14

Met Lys Ile Leu Ser Ala Leu Leu Leu Leu Phe Thr Leu Ala Phe Ala 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  15

Met Arg Pro Val Leu Ser Leu Leu Leu Leu Leu Ala Ser Ser Val Leu 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  16

Met Phe Val Ile Gln Leu Ala Phe Leu Cys Leu Gly Val Ser Leu Thr 
1               5                   10                  15      


Thr Ala 
        


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  17

Met Phe Lys Ser Leu Cys Met Leu Ile Gly Ser Cys Leu Leu Ser Ser 
1               5                   10                  15      


Val Leu Ala 
            


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  18

Met Leu Ser Ile Leu Ser Ala Leu Thr Leu Leu Gly Leu Ser Cys Ala 
1               5                   10                  15      


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  19

Met Gln Val Lys Ser Ile Val Asn Leu Leu Leu Ala Cys Ser Leu Ala 
1               5                   10                  15      


Val Ala 
        


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  20

Met Ile Leu His Thr Tyr Ile Ile Leu Ser Leu Leu Thr Ile Phe Pro 
1               5                   10                  15      


Lys Ala Ile Gly 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  21

Met Arg Leu Leu His Ile Ser Leu Leu Ser Ile Ile Ser Val Leu Thr 
1               5                   10                  15      


Lys Ala Asn Ala 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  22

Met Trp Arg Pro Leu Val Leu Val Leu Ala Leu Leu Arg Val Leu Ser 
1               5                   10                  15      


Pro Ala Lys Gly 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  23

Met Ile Phe Asn Leu Lys Thr Leu Ala Ala Val Ala Ile Ser Ile Ser 
1               5                   10                  15      


Gln Val Ser Ala 
            20  


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  24

Met Lys Tyr Leu Pro Leu Val Ala Thr Leu Ala Ser Ser Ala Leu Ala 
1               5                   10                  15      


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  25

Met Leu Ser Thr Ile Leu Asn Ile Phe Ile Leu Leu Leu Phe Ile Gln 
1               5                   10                  15      


Ala Ser Leu Gln 
            20  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  26

Met Ile Arg Leu Leu Ala Leu Phe Phe Ala Arg Gln Ile Leu Ala 
1               5                   10                  15  


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  27

Met Asn Leu Tyr Leu Ile Thr Leu Leu Phe Ala Ser Leu Cys Ser Ala 
1               5                   10                  15      


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  28

Met Gln Phe Gly Lys Val Leu Phe Ala Ile Ser Ala Leu Ala Val Thr 
1               5                   10                  15      


Ala Leu Gly 
            


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  29

Met Lys Leu Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Ala 
1               5                   10                  15      


Val Val Ser Ala 
            20  


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  30

Met Lys Ser Ser Trp Lys Ile Gly Leu Phe Phe Ile Ala Phe Val Val 
1               5                   10                  15      


Glu Leu Val Ser Cys 
            20      


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  31

Met Leu Arg Leu Leu Thr Ile Gly Ser Ile Ala Val Ser Leu Phe Pro 
1               5                   10                  15      


Ala Ser Ala 
            


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  32

Met Leu Tyr Leu Val Thr Val Leu Leu Phe Leu Val His Val Val Leu 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  33

Met Asn Pro Ser Ser Leu Ile Leu Leu Ala Leu Ser Ile Gly Tyr Ser 
1               5                   10                  15      


Ile Ala 
        


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  34

Met Tyr Gln Ala Leu Leu Val Leu Ser Leu Ile Cys Phe Ser Ser Ala 
1               5                   10                  15      


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  35

Met Arg Phe Ile Asn Leu Thr Ile Thr Ser Leu Leu Ala Leu Ala Ser 
1               5                   10                  15      


Arg Thr Thr Ala 
            20  


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  36

Met Lys Ser Val Ile Trp Ser Leu Leu Ser Leu Leu Ala Leu Ser Gln 
1               5                   10                  15      


Ala Leu Thr 
            


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  37

Met Leu Val Ala Val Ala Leu Val Leu Leu Leu Ser Thr Gly Tyr Ala 
1               5                   10                  15      


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  38

Met Phe Trp Leu Leu Val Leu Ser Leu Ile Ser Gln Ala Leu Ala 
1               5                   10                  15  


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  39

Met Lys Phe Phe Tyr Phe Ala Gly Phe Ile Ser Leu Leu Gln Leu Ile 
1               5                   10                  15      


Phe Ala 
        


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  40

Met Lys Phe Pro Val Pro Leu Leu Phe Leu Leu Gln Leu Phe Phe Ile 
1               5                   10                  15      


Ile Ala Thr Gln Gly 
            20      


<210>  41
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  41

Met Lys Leu Ala Ala Leu Ser Thr Ile Ala Leu Thr Ile Leu Pro Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  42

Met Leu Asn Arg Val Leu Leu Val Ala Leu Ser Cys Val Val Phe Phe 
1               5                   10                  15      


His Leu Val Thr Thr 
            20      


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  43

Met Asn Leu Thr Leu Ile Phe Thr Leu Ile Ser Leu Leu Leu Gly Val 
1               5                   10                  15      


Trp Ser 
        


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  44

Met Val Ser Leu Thr Arg Leu Leu Ile Thr Gly Ile Ala Thr Ala Leu 
1               5                   10                  15      


Gln Val Asn Ala 
            20  


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  45

Met Lys Leu Leu Asp Gly Leu Thr Ile Ser Leu Cys Ile Ser Met Ala 
1               5                   10                  15      


Thr Ser 
        


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion signal sequence

<400>  46

Met Met Ile Ser Ala Phe Val Trp Ser Ser Leu Ile Val Gly Leu Ile 
1               5                   10                  15      


Ser Gly Leu Leu Ala 
            20      


<210>  47
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  47

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Ile Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr 
            20                  25                  30          


Val Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Arg Gly Asp Ile Thr Ile Gly Pro Pro Asn Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Ser 
145                 150                 155                 160 


Ile Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr Val Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Asn Trp Arg Gly Asp Ile Thr Ile Gly Pro Pro Asn Val Glu Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys Gly Ala Gly 
225                 230                 235                 240 


Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser Tyr Asp Tyr 
                245                 250                 255     


Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Ile Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr Val Leu Gly Trp Phe Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Asn Trp Arg 
                325                 330                 335     


Gly Asp Ile Thr Ile Gly Pro Pro Asn Val Glu Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys Gly Ala Gly Thr Pro Leu 
    370                 375                 380                 


Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser Tyr Asp Tyr Trp Gly Arg 
385                 390                 395                 400 


Gly Thr Gln Val Thr Val Ser Ser 
                405             


<210>  48
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Leu Pro 
            20                  25                  30          


Ala Ser Gly Asn Ile Phe Asn Leu Leu Thr Ile Ala Trp Tyr Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Thr Ile Asn Ser Gly Ser 
    50                  55                  60                  


Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ser Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Gln Thr Ser Gly Ser Gly Ser Pro 
            100                 105                 110         


Asn Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            180                 185                 190         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser 
        275                 280                 285             


Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu 
    290                 295                 300                 


Phe Val Ala Arg Ile Ser Gln Gly Gly Thr Ala Ile Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Lys Asp Pro Ser Pro Tyr Tyr Arg Gly Ser Ala Tyr Leu 
        355                 360                 365             


Leu Ser Gly Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser 
385     


<210>  49
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr 
            20                  25                  30          


Val Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Arg Asp Asp Ile Thr Ile Gly Pro Pro Asn Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr Val Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Asn Trp Arg Asp Asp Ile Thr Ile Gly Pro Pro Asn Val Glu Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala Gly 
225                 230                 235                 240 


Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser Tyr Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  50
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Lys Ser Ser Gly Asp Ser Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Val Ser Arg Thr Gly Leu Tyr Thr Tyr Asp Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Ala Met 
                165                 170                 175     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
            180                 185                 190         


Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr Gly Asp 
        195                 200                 205             


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu 
                245                 250                 255     


Tyr Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270 


<210>  51
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Gln Gly Gly Thr Ala Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ser Pro Tyr Tyr Arg Gly Ser Ala Tyr Leu Leu Ser 
            100                 105                 110         


Gly Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                165                 170                 175     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
225                 230                 235                 240 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        275                 280                 285             


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Leu 
    290                 295                 300                 


Pro Ala Ser Gly Asn Ile Phe Asn Leu Leu Thr Ile Ala Trp Tyr Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Thr Ile Asn Ser Gly 
                325                 330                 335     


Ser Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ser Lys Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Thr Ser Gly Ser Gly Ser 
    370                 375                 380                 


Pro Asn Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395             


<210>  52
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Leu Pro 
            20                  25                  30          


Ala Ser Gly Asn Ile Phe Asn Leu Leu Thr Ile Ala Trp Tyr Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Thr Ile Asn Ser Gly Ser 
    50                  55                  60                  


Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ser Lys Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Gln Thr Ser Gly Ser Gly Ser Pro 
            100                 105                 110         


Asn Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr 
            180                 185                 190         


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser 
        275                 280                 285             


Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu 
    290                 295                 300                 


Phe Val Ala Arg Ile Ser Gln Gly Gly Thr Ala Ile Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Lys Asp Pro Ser Pro Tyr Tyr Arg Gly Ser Ala Tyr Leu 
        355                 360                 365             


Leu Ser Gly Ser Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser 
385     


<210>  53
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Ser Ile Tyr Leu Ile Asn 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Leu Thr Ser Gly Gly Ser Thr Asn Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ile Gly Gly Thr Leu Tyr Asp Arg Arg Arg Phe Glu Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Ala Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ala Ala Ile Thr Pro 
        195                 200                 205             


Arg Ala Phe Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr Leu Gln Met Val Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gln Leu Val 
                245                 250                 255     


Gly Ser Gly Ser Asn Leu Gly Arg Gln Glu Ser Tyr Ala Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
305                 310                 315                 320 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
                325                 330                 335     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp 
            340                 345                 350         


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
        355                 360                 365             


Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    370                 375                 380                 


Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
385                 390                 395                 400 


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
                405                 410                 415     


Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425                 430     


<210>  54
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ala Thr His His Thr Asn 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asn Ile Arg Thr Gly Gly Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Pro Trp Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr His Cys Lys 
                85                  90                  95      


Ser Asp Gly Ile Tyr Leu Asp Asp Ser Ser Gly Arg Trp Ala Asp Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ala Thr His His Thr Asn 
            180                 185                 190         


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        195                 200                 205             


Ala Asn Ile Arg Thr Gly Gly Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Ile Pro Trp Asn Ser Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr His Cys Lys 
                245                 250                 255     


Ser Asp Gly Ile Tyr Leu Asp Asp Ser Ser Gly Arg Trp Ala Asp Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285 


<210>  55
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ala Thr His His Thr Asn 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asn Ile Arg Thr Gly Gly Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Pro Trp Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr His Cys Lys 
                85                  90                  95      


Ser Asp Gly Ile Tyr Leu Asp Asp Ser Ser Gly Arg Trp Ala Asp Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            180                 185                 190         


Asp Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Ile 
        195                 200                 205             


Ser Cys Ile Ser Ser Ser Asp Gly Arg Pro Tyr Tyr Glu Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Val Thr Ser Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Ala Gly Ala Lys Ile Phe Ala Val Pro Gly Ser Leu Cys Ser Val 
            260                 265                 270         


Arg Asn Ala His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285         


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  56

Glu Glu Gly Val Ser Leu Glu Lys Arg 
1               5                   


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  57

Ala Lys Glu Glu Gly Val Ser Leu Glu Lys Arg 
1               5                   10      


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  58

Ala Ala Lys Glu Glu Gly Val Ser Leu Glu Lys Arg 
1               5                   10          


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  59

Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Glu Lys Arg 
1               5                   10              


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  60

Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Glu Lys Arg 
1               5                   10                  


<210>  61
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  61

Lys Arg 
1       


<210>  62
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acids derived from secretion signal sequence

<400>  62

Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
1               5                   10                  15      


Ser Leu Glu Lys Arg 
            20      


