                         SEQUENCE LISTING

<110>  Laboratorios LETI SL
 
<120>  Molecule for treating an inflammatory disorder

<130>  P6032062PCT

<150>  EP 11165248.3
<151>  2011-05-09

<150>  US 61/484,67
<151>  2011-05-09

<160>  57    

<170>  PatentIn version 3.3

<210>  1
<211>  267
<212>  PRT
<213>  Leishmania major

<400>  1

Met Thr Pro Leu Ser Leu Ser Ser Ser Arg His Ser Phe Lys Gln Asn 
1               5                   10                  15      


Glu Thr Gln Asn Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser 
            20                  25                  30          


Ser Ile Leu Gly Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu 
        35                  40                  45              


Ala Val Glu Ile Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu 
    50                  55                  60                  


Ile Lys Asp Gly Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg 
65                  70                  75                  80  


Ala Arg Trp Arg Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn 
                85                  90                  95      


Gly Val Gly Arg Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys 
            100                 105                 110         


Glu Leu Trp Met Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys 
        115                 120                 125             


Tyr Arg Ala Asp Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr 
    130                 135                 140                 


Met Arg Ala Lys Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu 
145                 150                 155                 160 


His Ile His Lys Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala 
                165                 170                 175     


Glu Gln Leu Ala Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys 
            180                 185                 190         


Ala Arg Lys Gln Glu Leu Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala 
        195                 200                 205             


Arg Arg Asp Asp Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala 
    210                 215                 220                 


Ala Lys Lys Ser Ala Ala Pro Ala Ala Lys Ser Ala Ala Pro Ala Ala 
225                 230                 235                 240 


Lys Ala Ala Ala Pro Ala Thr Lys Ala Ala Ala Ala Ala Pro Ala Thr 
                245                 250                 255     


Lys Gly Ala Ala Pro Val Lys Lys Ser Lys Lys 
            260                 265         


<210>  2
<211>  804
<212>  DNA
<213>  Leishmania major

<400>  2
atgacccctc tctccctctc ttcctcccgc cacagtttta agcagaacga aacgcagaac     60

atggtgtctc tgaagctgca ggctcgcctt gcgtcgagca tcctcggctg cggccgcgcc    120

cgcgtgtggc tggaccccaa cgaggcggtg gagatccaga acgcgaactc gcgcaagagc    180

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    240

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttgggcgc    300

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    360

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agattgaccg ccacgtgtac    420

cgcgacctgt acatgcgcgc gaagggtaac gtgttccgca acaagcgcaa ccttgtggag    480

cacatccaca agatcaagaa tgagaagaag aaggagcgcc agctggcgga gcagctcgcg    540

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgaagaag    600

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgccgctgc gcagaagaag    660

aaggcggacg ccgcgaagaa gtccgccgcg cctgctgcga agtccgccgc gcctgccgcg    720

aaggctgctg cccccgccac gaaggccgct gctgctgccc ccgccacgaa gggtgctgcg    780

ccggtgaaga agtcgaagaa gtaa                                           804


<210>  3
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  3
cgggatccat gacccctctc tccctctc                                        28


<210>  4
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  4
cccaagcttt tacttcttcg acttcttcac                                      30


<210>  5
<211>  250
<212>  PRT
<213>  Leishmania braziliensis

<400>  5

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Met Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Ser Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Gln Arg Asp Glu Gln His Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Val Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Thr Lys Ala Ala Ala Val Ser Ala Ala Lys Ala Ala 
    210                 215                 220                 


Ala Val Ser Val Ser Arg Ala Ala Ala Ala Val Ala Pro Ala Ala Lys 
225                 230                 235                 240 


Pro Ala Val Pro Ala Lys Lys Ser Lys Lys 
                245                 250 


<210>  6
<211>  753
<212>  DNA
<213>  Leishmania braziliensis

<400>  6
atggtgtctc tgaagctgca ggctcgcctc gcgtcgagca tcctcggctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcgatg gagatccaga acgcaaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc attcgtaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaagatgaa ggaggcgaag gacatggggc gccacagcgg cgttggccgg    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagc tgtggatgcg ccgcctgcgc    300

attctgcgtc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgcgacctgt acgtgcgcgc gaagggtaac gtgttccgca acaagcgcaa ccttatggag    420

cacatccaca agatcaagaa cgagaagaag aaggagcggc agctggcgga gcagcttgcg    480

gcgaagcacc agcgcgacga gcagcaccgc aacaaggctc gcaagcagga gctgaagaag    540

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgctgctgc gcagaagaag    600

aaggcggacg ttgcgaagaa gtctgctgcc cctgctacga aggctgctgc tgtctccgcc    660

gcgaaggctg ctgctgtctc cgtctcgagg gctgctgctg ctgtggctcc cgctgcgaag    720

cctgctgtgc cggcgaagaa gtcgaagaag taa                                 753


<210>  7
<211>  271
<212>  PRT
<213>  Leishmania braziliensis

<400>  7

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Met Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Ser Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Gln Arg Asp Glu Gln His Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Val Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Thr Lys Ala Ala Ala Val Ser Ala Ala Lys Ala Ala 
    210                 215                 220                 


Ala Val Ser Ala Ala Lys Ala Ala Ala Val Ser Val Ser Arg Ala Ala 
225                 230                 235                 240 


Ala Ala Val Ala Pro Ala Ala Lys Pro Ala Val Pro Ala Lys Ala Ala 
                245                 250                 255     


Ala Pro Ala Ala Lys Gly Ala Val Pro Ala Lys Lys Ser Lys Lys 
            260                 265                 270     


<210>  8
<211>  816
<212>  DNA
<213>  Leishmania braziliensis

<400>  8
atggtgtctc tgaagctgca ggctcgcctc gcgtcgagca tcctcggctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcgatg gagatccaga acgcaaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc attcgtaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaagatgaa ggaggcgaag gacatggggc gccacagcgg cgttggccgg    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagc tgtggatgcg ccgcctgcgc    300

attctgcgtc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgcgacctgt acgtgcgcgc gaagggtaac gtgttccgca acaagcgcaa ccttatggag    420

cacatccaca agatcaagaa cgagaagaag aaggagcggc agctggcgga gcagcttgcg    480

gcgaagcacc agcgcgacga gcagcaccgc aacaaggctc gcaagcagga gctgaagaag    540

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgctgctgc gcagaagaag    600

aaggcggacg ttgcgaagaa gtctgctgcc cctgctacga aggctgctgc tgtctccgcc    660

gcgaaggctg ctgctgtctc cgccgcgaag gctgctgctg tctccgtctc gagggctgct    720

gctgctgtgg ctcccgctgc gaagcctgct gtgccggcga aggctgcggc gcctgctgcg    780

aagggtgctg tgccggcgaa gaagtcgaag aagtaa                              816


<210>  9
<211>  176
<212>  PRT
<213>  Leishmania braziliensis

<400>  9

Met Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala 
1               5                   10                  15      


Asp Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala 
            20                  25                  30          


Lys Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His 
        35                  40                  45              


Lys Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu 
    50                  55                  60                  


Ala Ala Lys His Gln Arg Asp Glu Gln His Arg Asn Lys Ala Arg Lys 
65                  70                  75                  80  


Gln Glu Leu Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp 
                85                  90                  95      


Asp Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Val Ala Lys Lys 
            100                 105                 110         


Ser Ala Ala Pro Ala Thr Lys Ala Ala Ala Val Ser Ala Ala Lys Ala 
        115                 120                 125             


Ala Ala Val Ser Ala Ala Lys Ala Ala Ala Val Ser Val Ser Arg Ala 
    130                 135                 140                 


Ala Ala Ala Val Ala Pro Ala Ala Lys Pro Ala Val Pro Ala Lys Ala 
145                 150                 155                 160 


Ala Ala Pro Ala Ala Lys Gly Ala Val Pro Ala Lys Lys Ser Lys Lys 
                165                 170                 175     


<210>  10
<211>  531
<212>  PRT
<213>  Leishmania braziliensis

<400>  10

Ala Thr Gly Cys Gly Cys Cys Gly Cys Cys Thr Gly Cys Gly Cys Ala 
1               5                   10                  15      


Thr Thr Cys Thr Gly Cys Gly Thr Cys Gly Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Gly Cys Ala Ala Gly Thr Ala Cys Cys Gly Cys Gly Cys Gly 
        35                  40                  45              


Gly Ala Cys Ala Ala Gly Ala Ala Gly Ala Thr Cys Gly Ala Cys Cys 
    50                  55                  60                  


Gly Cys Cys Ala Cys Gly Thr Gly Thr Ala Cys Cys Gly Cys Gly Ala 
65                  70                  75                  80  


Cys Cys Thr Gly Thr Ala Cys Gly Thr Gly Cys Gly Cys Gly Cys Gly 
                85                  90                  95      


Ala Ala Gly Gly Gly Thr Ala Ala Cys Gly Thr Gly Thr Thr Cys Cys 
            100                 105                 110         


Gly Cys Ala Ala Cys Ala Ala Gly Cys Gly Cys Ala Ala Cys Cys Thr 
        115                 120                 125             


Thr Ala Thr Gly Gly Ala Gly Cys Ala Cys Ala Thr Cys Cys Ala Cys 
    130                 135                 140                 


Ala Ala Gly Ala Thr Cys Ala Ala Gly Ala Ala Cys Gly Ala Gly Ala 
145                 150                 155                 160 


Ala Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Cys Gly Gly Cys Ala 
                165                 170                 175     


Gly Cys Thr Gly Gly Cys Gly Gly Ala Gly Cys Ala Gly Cys Thr Thr 
            180                 185                 190         


Gly Cys Gly Gly Cys Gly Ala Ala Gly Cys Ala Cys Cys Ala Gly Cys 
        195                 200                 205             


Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Ala Cys Cys Gly 
    210                 215                 220                 


Cys Ala Ala Cys Ala Ala Gly Gly Cys Thr Cys Gly Cys Ala Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Ala Gly Cys Thr Gly Ala Ala Gly Ala Ala Gly Cys 
                245                 250                 255     


Gly Cys Gly Ala Gly Ala Ala Gly Gly Ala Gly Cys Gly Cys Gly Ala 
            260                 265                 270         


Gly Cys Gly Cys Gly Cys Gly Ala Gly Gly Cys Gly Cys Gly Ala Cys 
        275                 280                 285             


Gly Ala Cys Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly 
    290                 295                 300                 


Cys Gly Cys Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Cys 
305                 310                 315                 320 


Gly Gly Ala Cys Gly Thr Thr Gly Cys Gly Ala Ala Gly Ala Ala Gly 
                325                 330                 335     


Thr Cys Thr Gly Cys Thr Gly Cys Cys Cys Cys Thr Gly Cys Thr Ala 
            340                 345                 350         


Cys Gly Ala Ala Gly Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Thr 
        355                 360                 365             


Cys Thr Cys Cys Gly Cys Cys Gly Cys Gly Ala Ala Gly Gly Cys Thr 
    370                 375                 380                 


Gly Cys Thr Gly Cys Thr Gly Thr Cys Thr Cys Cys Gly Cys Cys Gly 
385                 390                 395                 400 


Cys Gly Ala Ala Gly Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Thr 
                405                 410                 415     


Cys Thr Cys Cys Gly Thr Cys Thr Cys Gly Ala Gly Gly Gly Cys Thr 
            420                 425                 430         


Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Thr Gly Gly Cys Thr Cys 
        435                 440                 445             


Cys Cys Gly Cys Thr Gly Cys Gly Ala Ala Gly Cys Cys Thr Gly Cys 
    450                 455                 460                 


Thr Gly Thr Gly Cys Cys Gly Gly Cys Gly Ala Ala Gly Gly Cys Thr 
465                 470                 475                 480 


Gly Cys Gly Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Gly Ala 
                485                 490                 495     


Ala Gly Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Gly Gly Cys 
            500                 505                 510         


Gly Ala Ala Gly Ala Ala Gly Thr Cys Gly Ala Ala Gly Ala Ala Gly 
        515                 520                 525             


Thr Ala Ala 
    530     


<210>  11
<211>  245
<212>  PRT
<213>  Leishmania infantum

<400>  11

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Val Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu His Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Ser Ala Ala 
    210                 215                 220                 


Pro Ala Ala Lys Val Ala Ala Pro Ala Thr Lys Gly Ala Ala Pro Val 
225                 230                 235                 240 


Lys Lys Ser Lys Lys 
                245 


<210>  12
<211>  738
<212>  DNA
<213>  Leishmania infantum

<400>  12
atggtgtctc tgaagctgca ggctcgcctt gcgtcgagca tcctcggctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcggtg gagatccaga acgcgaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttggccgc    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    300

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgagacctgt acgtgcgcgc gaagggtaat gtgttccgca acaagcgcaa ccttgtggag    420

cacatccaca agatcaagaa tgagaagaag aaggagcgcc agctggcgga gcagcttgcg    480

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgaggaag    540

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgccgctgc gcagaagaag    600

aaggcggacg ccgcgaagaa gtctgccgcg cctgccgcga agtctgccgc gcctgccgcg    660

aagtctgccg cgcctgccgc gaaggttgct gcccccgcca cgaagggtgc tgcgccggtg    720

aagaagtcga agaagtaa                                                  738


<210>  13
<211>  238
<212>  PRT
<213>  Leishmania infantum

<400>  13

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Val Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu His Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Val Ala Ala 
    210                 215                 220                 


Pro Ala Thr Lys Gly Ala Ala Pro Val Lys Lys Ser Lys Lys 
225                 230                 235             


<210>  14
<211>  717
<212>  DNA
<213>  Leishmania infantum

<400>  14
atggtgtctc tgaagctgca ggctcgcctt gcgtcgagca tcctcggctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcggtg gagatccaga acgcgaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttggccgc    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    300

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgagacctgt acgtgcgcgc gaagggtaat gtgttccgca acaagcgcaa ccttgtggag    420

cacatccaca agatcaagaa tgagaagaag aaggagcgcc agctggcgga gcagcttgcg    480

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgaggaag    540

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgccgctgc gcagaagaag    600

aaggcggacg ccgcgaagaa gtctgccgcg cctgccgcga agtctgccgc gcctgccgcg    660

aaggttgctg cccccgccac gaagggtgct gcgccggtga agaagtcgaa gaagtaa       717


<210>  15
<211>  247
<212>  PRT
<213>  Leishmania mexicana

<400>  15

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Ser 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Met Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Met Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu Tyr Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Ala Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Glu Arg Glu Arg Ala Lys Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Ala Ala Ala 
    210                 215                 220                 


Pro Val Ala Lys Ala Ala Ala Ala Ala Pro Ala Ala Lys Gly Ala Ala 
225                 230                 235                 240 


Pro Val Lys Lys Ser Lys Lys 
                245         


<210>  16
<211>  744
<212>  DNA
<213>  Leishmania mexicana

<400>  16
atggtgtctc tgaagctgca agctcggctt gcgtcgagca tcctcagctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcgatg gagatccaga acgcgaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttggccgc    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    300

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgagacctgt acatgcgcgc gaagggtaac gtgttccgca acaagcgcaa ccttgtggag    420

tacatccaca agatcaagaa tgagaagaag aaggcgcgcc agctggcgga gcagcttgcg    480

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgcggaag    540

cgcgagaagg agcgcgagcg cgcgaagcgc gacgacgctg ctgccgctgc gcagaagaag    600

aaggcggacg ccgcgaagaa gtccgccgcg cctgctgcga agtccgccgc gcctgccgcg    660

aaggctgctg cccccgtcgc gaaggccgct gctgctgccc ccgcggcgaa gggtgctgcg    720

ccggtgaaga agtcgaagaa gtaa                                           744


<210>  17
<211>  247
<212>  PRT
<213>  Leishmania mexicana

<400>  17

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Ser 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Met Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Met Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu Tyr Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Ala Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Glu Arg Glu Arg Ala Lys Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Pro Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Ala Ala Ala 
    210                 215                 220                 


Pro Val Ala Lys Ala Ala Ala Ala Ala Pro Ala Ala Lys Gly Ala Ala 
225                 230                 235                 240 


Pro Val Lys Lys Ser Lys Lys 
                245         


<210>  18
<211>  744
<212>  DNA
<213>  Leishmania mexicana

<400>  18
atggtgtctc tgaagctgca agctcggctt gcgtcgagca tcctcagctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcgatg gagatccaga acgcgaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttggccgc    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    300

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgagacctgt acatgcgcgc gaagggtaac gtgttccgca acaagcgcaa ccttgtggag    420

tacatccaca agatcaagaa tgagaagaag aaggcgcgcc agctggcgga gcagcttgcg    480

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgcggaag    540

cgcgagaagg agcgcgagcg cgcgaagcgc gacgacgctg ctgccgctgc gcagaagaag    600

aaggcggacg ccgcgaagaa gtccgccgcg cctgctgcga agtccgccgc gcctgccgcg    660

aaggctgctg cccccgtcgc gaaggccgct gctgctgccc ccgcggcgaa gggtgctgcg    720

ccggtgaaga agtcgaagaa gtaa                                           744


<210>  19
<211>  245
<212>  PRT
<213>  Leishmania donovani

<400>  19

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly 
1               5                   10                  15      


Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala Val Glu Ile 
            20                  25                  30          


Gln Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg Trp Arg 
    50                  55                  60                  


Lys Met Lys Glu Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp 
            100                 105                 110         


Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Val Arg Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val Glu His Ile His Lys 
    130                 135                 140                 


Ile Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala Lys Lys Ser 
        195                 200                 205             


Ala Ala Ser Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Ser Ala Ala 
    210                 215                 220                 


Pro Ala Ala Lys Val Ala Ala Pro Ala Thr Lys Gly Ala Ala Pro Val 
225                 230                 235                 240 


Lys Lys Ser Lys Lys 
                245 


<210>  20
<211>  738
<212>  DNA
<213>  Leishmania donovani

<400>  20
atggtgtctc tgaagctgca ggctcgcctt gcgtcgagca tcctcggctg cggccgcgcc     60

cgcgtgtggc tggaccccaa cgaggcggtg gagatccaga atgcgaactc gcgcaagagc    120

gtgcgcaagc tgatcaagga tggcttcatc atccgcaagc cggtgaaggt gcactcgcgc    180

gcgcggtggc gtaaaatgaa ggaggcgaag gacatggggc gccacaacgg cgttggccgc    240

cgcgagggta gccgcgaggc ccgcatgccg agcaaggagt tgtggatgcg ccgcctgcgc    300

attctgcgcc gcctgctgcg caagtaccgc gcggacaaga agatcgaccg ccacgtgtac    360

cgagacctgt acgtgcgcgc gaagggtaat gtgttccgca acaagcgcaa ccttgtggag    420

cacatccaca agatcaagaa tgagaagaag aaggagcgcc agctggcgga gcagcttgcg    480

gcgaagcacc tgcgcgacga gcagaaccgc aacaaggctc gcaagcagga gctgaggaag    540

cgcgagaagg agcgcgagcg cgcgaggcgc gacgacgctg ctgccgctgc gcagaagaag    600

aaggcggacg ccgcgaagaa gtctgccgcg tctgctgcga agtctgccgc gcctgctgcg    660

aagtctgccg cgcctgccgc gaaggttgct gcccccgcca cgaagggtgc tgcgccggtg    720

aagaagtcga agaagtaa                                                  738


<210>  21
<211>  372
<212>  PRT
<213>  Trypanosoma cruzi

<400>  21

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ala Asp Ile Leu Arg 
1               5                   10                  15      


Cys Gly Arg His Arg Val Trp Leu Asp Pro Asn Glu Ala Ser Glu Ile 
            20                  25                  30          


Ser Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ser Arg Trp Arg 
    50                  55                  60                  


His Met Lys Glu Ala Lys Ser Met Gly Arg His Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Thr Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Glu Glu 
            100                 105                 110         


Lys Lys Ile Asp Arg His Ile Tyr Arg Glu Leu Tyr Val Lys Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Val Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys Arg Leu Lys Asp Glu Gln His Arg His Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Asp Arg Glu Arg Ala Arg Arg Glu Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Lys Gln Lys Ala Ala Ala Lys Lys Ala 
        195                 200                 205             


Ala Ala Pro Ser Gly Lys Lys Ser Ala Lys Ala Ala Thr Ala Pro Ala 
    210                 215                 220                 


Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala 
225                 230                 235                 240 


Ala Ala Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala 
                245                 250                 255     


Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala Ala Pro 
            260                 265                 270         


Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys 
        275                 280                 285             


Ala Ala Ala Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala 
    290                 295                 300                 


Ala Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala Ala 
305                 310                 315                 320 


Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala 
                325                 330                 335     


Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala 
            340                 345                 350         


Ala Thr Ala Pro Ala Lys Ala Ala Thr Ala Pro Val Gly Lys Lys Ala 
        355                 360                 365             


Gly Gly Lys Lys 
    370         


<210>  22
<211>  1119
<212>  DNA
<213>  Trypanosoma cruzi

<400>  22
atggtgtcgc tgaagctgca ggctcgtttg gcggcggaca ttctccgctg cggtcgccac     60

cgtgtgtggc tggatcctaa tgaggcctct gagatttcca atgcaaactc gcgcaagagc    120

gtgcgcaagt tgatcaagga tggtctgatt attcgcaagc ctgtcaaggt gcactcgcgc    180

tcccgctggc gccacatgaa ggaggcgaag agcatgggcc gccacgaggg cgctgggcgc    240

cgcgagggta cccgcgaagc ccgcatgccg agcaaggagc tgtggatgcg ccgtctgcgc    300

attctccgcc gcctgctgcg caagtaccgc gaggagaaga agattgaccg ccacatctac    360

cgcgagctgt acgtgaaggc gaaggggaac gtgtttcgca acaagcgtaa cctcatggag    420

cacatccaca aggtgaagaa cgagaagaag aaggaaaggc agctggctga gcagctcgcg    480

gcgaagcgcc tgaaggatga gcagcaccgt cacaaggccc gcaagcagga gctgcgtaag    540

cgcgagaagg accgcgagcg tgcgcgtcgc gaagatgctg ccgctgccgc cgccgcgaag    600

cagaaagctg ctgcgaagaa ggccgctgct ccctctggca agaagtccgc gaaggctgct    660

actgcacctg cgaaggccgc tgctgcacct gcgaaggccg ctgctgcacc tgcgaaggct    720

gctgctgcac ctgcgaaggc tgctgctgca cctgcgaagg ctgctgctgc acctgcgaag    780

gctgctactg cacctgcgaa ggccgctgct gcacctgcga aggctgctac tgcacctgcg    840

aaggccgctg ctgcacctgc gaaggctgct gctgcacctg cgaaggctgc tactgcacct    900

gcgaaggccg ctgctgcacc tgcgaaggct gctactgcac ctgcgaaggc cgctgctgca    960

cctgcgaagg ctgctactgc acctgcgaag gccgctgctg cacctgcgaa ggccgctgct   1020

gcacctgcga aggctgctac tgcacctgcg aaggccgcta ctgcacctgc gaaggctgct   1080

actgcacccg ttggaaagaa ggctggtggc aagaagtga                          1119


<210>  23
<211>  356
<212>  PRT
<213>  Trypanosoma cruzi

<400>  23

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ala Asp Ile Leu Arg 
1               5                   10                  15      


Cys Gly Arg His Arg Val Trp Leu Asp Pro Asn Glu Ala Ser Glu Ile 
            20                  25                  30          


Ser Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ser Arg Trp Arg 
    50                  55                  60                  


His Met Lys Glu Ala Lys Ser Met Gly Arg His Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Thr Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Glu Glu 
            100                 105                 110         


Lys Lys Ile Asp Arg His Ile Tyr Arg Glu Leu Tyr Val Lys Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Val Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys Arg Leu Lys Asp Glu Gln His Arg His Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Asp Arg Glu Arg Ala Arg Arg Glu Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Lys Gln Lys Ala Ala Ala Lys Lys Ala 
        195                 200                 205             


Ala Ala Pro Ser Gly Lys Lys Ser Ala Lys Ala Ala Ala Pro Ala Lys 
    210                 215                 220                 


Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Thr Ala 
225                 230                 235                 240 


Ala Ala Pro Ala Lys Ala Ala Ala Pro Ala Lys Ala Ala Ala Pro Pro 
                245                 250                 255     


Ala Lys Ala Ala Ala Pro Pro Ala Lys Thr Ala Ala Pro Pro Ala Lys 
            260                 265                 270         


Thr Ala Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala 
        275                 280                 285             


Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Ala 
    290                 295                 300                 


Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala Pro Pro Ala 
305                 310                 315                 320 


Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala 
                325                 330                 335     


Ala Ala Pro Pro Ala Lys Ala Ala Ala Ala Pro Val Gly Lys Lys Ala 
            340                 345                 350         


Gly Gly Lys Lys 
        355     


<210>  24
<211>  1071
<212>  DNA
<213>  Trypanosoma cruzi

<400>  24
atggtgtcgc tgaagctgca ggctcgtttg gcggcggaca ttctccgctg cggtcgccac     60

cgtgtgtggc tggaccctaa tgaggcctct gagatttcca atgcaaactc gcgcaagagc    120

gtgcgcaagt tgatcaagga tggtctgatt attcgcaagc ctgtcaaggt gcactcgcgc    180

tcccgctggc gccacatgaa ggaggcgaag agcatgggcc gccacgaggg cgctgggcgc    240

cgcgagggta cccgcgaagc ccgcatgccg agcaaggagc tgtggatgcg ccgtctgcgc    300

attctccgcc gcctgctgcg caagtaccgc gaggagaaga agattgaccg ccacatttac    360

cgcgagctgt acgtgaaggc gaaggggaac gtgtttcgca acaagcgtaa cctcatggag    420

cacatccaca aggtgaagaa cgagaagaag aaggaaaggc agctggctga gcagctcgcg    480

gcgaagcgcc tgaaggatga gcagcaccgt cacaaggccc gcaagcagga gctgcgtaag    540

cgcgagaagg accgcgagcg tgcgcgtcgc gaagatgctg ccgctgccgc cgccgcgaag    600

cagaaagctg ctgcgaagaa ggccgctgct ccctctggca agaagtccgc gaaggctgct    660

gcacccgcga aggctgctgc tgcacccgcg aaggccgctg ctccacccgc gaagaccgct    720

gctgcacccg cgaaggctgc tgcacctgcc aaggctgctg ctccacccgc gaaggctgct    780

gctccacccg cgaagaccgc tgctccaccc gcgaagaccg ctgctccacc cgcgaaggct    840

gctgctccac ccgcgaaggc cgctgctcca cccgcgaagg ccgctgctcc acccgcgaag    900

gccgctgctg cacccgcgaa ggccgctgct gcacccgcga aggctgctgc tccacccgcg    960

aaggccgctg ctccacccgc gaaggctgct gctccacccg cgaaggctgc tgctccaccc   1020

gcgaaggctg ctgctgctcc cgttggaaag aaggctggtg gcaagaagtg a            1071


<210>  25
<211>  343
<212>  PRT
<213>  Trypanosoma crusi

<400>  25

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ala Asp Ile Leu Arg 
1               5                   10                  15      


Cys Gly Arg His Arg Val Trp Leu Asp Pro Asn Glu Ala Ser Glu Ile 
            20                  25                  30          


Ser Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ser Arg Trp Arg 
    50                  55                  60                  


His Met Lys Glu Ala Lys Ser Met Gly Arg His Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Thr Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Glu Glu 
            100                 105                 110         


Lys Lys Ile Asp Arg His Ile Tyr Arg Glu Leu Tyr Val Lys Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Val Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys Arg Leu Lys Asp Glu Gln His Arg His Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Asp Arg Glu Arg Ala Arg Arg Glu Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Lys Gln Lys Ala Ala Ala Lys Lys Ala 
        195                 200                 205             


Ala Ala Pro Ser Gly Lys Lys Ser Ala Lys Ala Ala Ile Ala Pro Ala 
    210                 215                 220                 


Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala 
225                 230                 235                 240 


Ala Ala Ala Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Ala 
                245                 250                 255     


Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala Ala Pro 
            260                 265                 270         


Ala Lys Thr Ala Ala Ala Pro Ala Lys Ala Ala Ala Pro Ala Lys Ala 
        275                 280                 285             


Ala Ala Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Ala 
    290                 295                 300                 


Ala Pro Ala Lys Ala Ala Thr Ala Pro Ala Lys Ala Ala Thr Ala Pro 
305                 310                 315                 320 


Ala Lys Ala Ala Ala Ala Pro Ala Lys Ala Ala Thr Ala Pro Val Gly 
                325                 330                 335     


Lys Lys Ala Gly Gly Lys Lys 
            340             


<210>  26
<211>  1032
<212>  DNA
<213>  Trypanosoma cruzi

<400>  26
atggtgtcgc tgaagctgca ggctcgtttg gcggcggaca ttctccgctg cggtcgccac     60

cgtgtgtggc tggaccctaa tgaggcctct gagatttcca atgcaaactc gcgcaagagc    120

gtgcgcaagt tgatcaagga tggtctgatt attcgcaagc ctgtcaaggt gcactcgcgc    180

tcccgctggc gccacatgaa ggaggcgaag agcatgggcc gccacgaggg cgctgggcgc    240

cgcgagggta cccgcgaagc ccgcatgccg agcaaggagc tgtggatgcg ccgtctgcgc    300

attctccgcc gcctgctgcg caagtaccgc gaggagaaga agattgaccg ccacatctac    360

cgcgagctgt acgtgaaggc gaaggggaac gtgtttcgca acaagcgtaa cctcatggag    420

cacatccaca aggtgaagaa cgagaagaag aaggaaaggc agctggctga gcagctcgcg    480

gcgaagcgcc tgaaggatga gcagcaccgt cacaaggccc gcaagcagga gctgcgtaag    540

cgcgagaagg accgcgagcg tgcgcgtcgc gaagatgctg ccgctgccgc cgccgcgaag    600

cagaaagctg ctgcgaagaa ggccgctgct ccctctggca agaagtccgc gaaggctgct    660

attgcacctg cgaaggccgc tgctgcacct gcgaaggccg ctgctgcacc tgcgaaggct    720

gctgctgcac ctgcgaaggc cgctgctgca cctgcgaagg ctgctgctgc acctgcgaag    780

gctgctactg cacctgcgaa ggctgctgct gcacctgcca agaccgctgc tgcacctgcg    840

aaggctgctg cacctgcgaa ggccgctgct gcacctgcga aggccgctac tgcacctgcg    900

aaggctgctg ctgcacctgc gaaggccgct actgcacctg cgaaggctgc tactgcacct    960

gcgaaggctg ctgctgcacc tgcgaaggcc gctactgcac ccgttggaaa gaaggctggt   1020

ggcaagaagt ga                                                       1032


<210>  27
<211>  357
<212>  PRT
<213>  Trypanosoma cruzi

<400>  27

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ala Asp Ile Leu Arg 
1               5                   10                  15      


Cys Gly Arg His Arg Val Trp Leu Asp Pro Asn Glu Ala Ser Glu Ile 
            20                  25                  30          


Ser Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ser Arg Trp Arg 
    50                  55                  60                  


His Met Lys Glu Ala Lys Ser Met Gly Arg His Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Thr Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Glu Glu 
            100                 105                 110         


Lys Lys Ile Asp Arg His Ile Tyr Arg Glu Leu Tyr Val Lys Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Val Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys Arg Leu Lys Asp Glu Gln His Arg His Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Arg Lys Arg Glu Lys Asp Arg Glu Arg Ala Arg Arg Glu Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Lys Gln Lys Ala Ala Ala Lys Lys Ala 
        195                 200                 205             


Ala Ala Pro Ser Gly Lys Lys Ser Ala Lys Ala Ala Ala Pro Ala Lys 
    210                 215                 220                 


Ala Ala Ala Ala Pro Ala Lys Thr Ala Ala Pro Pro Ala Lys Ala Ala 
225                 230                 235                 240 


Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Pro 
                245                 250                 255     


Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala 
            260                 265                 270         


Lys Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Pro Pro Ala Lys Ala 
        275                 280                 285             


Ala Ala Pro Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Thr Ala Ala 
    290                 295                 300                 


Pro Pro Ala Lys Ala Ala Ala Ala Pro Ala Lys Thr Ala Ala Pro Pro 
305                 310                 315                 320 


Ala Lys Thr Ala Ala Pro Pro Ala Lys Ala Ala Thr Pro Pro Ala Lys 
                325                 330                 335     


Ala Ala Ala Pro Pro Ala Lys Ala Ala Ala Ala Pro Val Gly Lys Lys 
            340                 345                 350         


Ala Gly Gly Lys Lys 
        355         


<210>  28
<211>  1074
<212>  DNA
<213>  Trypanosoma cruzi

<400>  28
atggtgtcgc tgaagctgca ggctcgtttg gcggcggaca ttctccgctg cggtcgccac     60

cgtgtgtggc tggaccctaa tgaggcctct gagatttcca atgcaaactc gcgcaagagc    120

gtgcgcaagt tgatcaagga tggtctgatt attcgcaagc ctgtcaaggt gcactcgcgc    180

tcccgctggc gccacatgaa ggaggcgaag agcatgggcc gccacgaggg cgctgggcgc    240

cgcgagggta cccgcgaagc ccgcatgccg agcaaggagc tgtggatgcg ccgtctgcgc    300

attctccgcc gcctgctgcg caagtaccgc gaggagaaga agattgaccg ccacatttac    360

cgcgagctgt acgtgaaggc gaaggggaac gtgtttcgca acaagcgtaa cctcatggag    420

cacatccaca aggtgaagaa cgagaagaag aaggaaaggc agctggctga gcagctcgcg    480

gcgaagcgcc tgaaggatga gcagcaccgt cacaaggccc gcaagcagga gctgcgtaag    540

cgcgagaagg accgcgagcg tgcgcgtcgc gaagatgctg ccgctgccgc cgccgcgaag    600

cagaaagctg ctgcgaagaa ggccgctgct ccctctggca agaagtccgc gaaggctgct    660

gcacctgcca aggctgctgc tgcacccgcg aagaccgctg ctccacccgc gaaggccgct    720

gctccacccg cgaaggctgc tgctccaccc gcgaaggctg ctgctccacc cgcgaaggct    780

gctgctccac ccgcgaaggc tgctgctcca cccgcgaagg ctgctgctcc acccgcgaag    840

gctgctgctc cacccgcgaa ggctgctgct ccacccgcga aggctgctgc tgcacccgcg    900

aagaccgctg ctccacccgc gaaggctgct gctgcacccg cgaagaccgc tgctccaccc    960

gcgaagaccg ctgctccacc cgcgaaggcc gctactccac ccgcgaaggc tgctgctcca   1020

cccgcgaagg ctgctgctgc tcccgttgga aagaaggctg gtggcaagaa gtga         1074


<210>  29
<211>  260
<212>  PRT
<213>  Trypanosoma brucei

<400>  29

Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala Ala Asp Ile Leu Arg 
1               5                   10                  15      


Cys Gly Arg Gly Arg Val Trp Leu Asp Pro Asn Glu Ala Val Glu Ile 
            20                  25                  30          


Arg Asn Ala Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Val Met Arg Lys Pro Val Lys Val His Ser Arg Ser Arg Trp Arg 
    50                  55                  60                  


Gln Met Lys Leu Ala Lys Ser Met Gly Arg His Glu Gly Thr Gly Arg 
65                  70                  75                  80  


Arg Glu Gly Thr Arg Glu Ala Arg Met Pro Ser Lys Asp Leu Trp Met 
                85                  90                  95      


Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu Arg Lys Tyr Arg Glu Glu 
            100                 105                 110         


Lys Lys Ile Asp Arg His Ile Tyr Arg Glu Leu Tyr Met Lys Ala Lys 
        115                 120                 125             


Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Val Lys Asn Glu Lys Lys Lys Ala Arg Gln Leu Ala Glu Gln Leu Ala 
145                 150                 155                 160 


Ala Lys Arg Leu Lys Asp Glu Gln Asn Arg Arg Lys Ala Arg Lys Gln 
                165                 170                 175     


Glu Leu Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Lys Gln Arg Ala Ala Ala Lys Lys Ala 
        195                 200                 205             


Ala Ala Pro Ala Ala Lys Lys Gly Gly Lys Ala Val Ala Pro Ala Thr 
    210                 215                 220                 


Pro Ala Lys Ala Ala Pro Ala Lys Ala Ala Ala Ala Lys Val Ala Pro 
225                 230                 235                 240 


Ala Lys Ala Ala Pro Ala Lys Ala Ala Ser Pro Ala Gly Lys Lys Ala 
                245                 250                 255     


Ala Gly Lys Lys 
            260 


<210>  30
<211>  783
<212>  DNA
<213>  Trypanosoma brucei

<400>  30
atggtgtcac tgaagctcca agctcgcctg gcagcggaca tcctgcgctg cggccgcggc     60

cgcgtgtggt tggaccctaa cgaagcagta gagattcgca atgccaattc acgcaagagt    120

gtacgcaagt tgatcaaaga cggtttggta atgcgaaagc ctgttaaggt gcattcgcgc    180

tcccgctggc gccagatgaa gttggcgaag agcatgggac gccacgaggg taccggccgc    240

cgcgagggta ctcgcgaagc acgcatgccc agcaaggacc tttggatgcg ccgacttcgc    300

attcttcgcc gtttgcttcg caagtaccgc gaagaaaaga agattgatcg gcacatctac    360

cgcgagctgt acatgaaggc aaagggcaac gtgttccgca acaagcgcaa ccttatggag    420

cacatccaca aggtgaagaa cgagaagaag aaggctcgtc agcttgctga gcaactcgcg    480

gcgaaacgcc taaaggacga gcagaaccgc cgcaaggcac gaaagcagga gctgaagaag    540

cgtgagaagg aacgtgagcg tgcacgccgt gacgatgccg ctgctgctgc cgctgccaaa    600

caacgagctg ccgcgaagaa ggctgccgct cccgctgcca agaagggtgg caaggctgtt    660

gcccccgcca ctcctgcgaa ggccgcccct gcaaaggccg ccgctgcgaa ggttgcccca    720

gcgaaggcgg ctcccgcaaa ggccgccagc cctgccggga agaaggcagc gggtaagaag    780

tga                                                                  783


<210>  31
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 1

<400>  31

Met Thr Pro Leu Ser Leu Ser Ser Ser Arg His Ser Phe Lys Gln Asn 
1               5                   10                  15      


Glu Thr Gln Asn 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 2

<400>  32

Ser Phe Lys Gln Asn Glu Thr Gln Asn Met Val Ser Leu Lys Leu Gln 
1               5                   10                  15      


Ala Arg Leu Ala 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 3

<400>  33

Ser Leu Lys Leu Gln Ala Arg Leu Ala Ser Ser Ile Leu Gly Cys Gly 
1               5                   10                  15      


Arg Ala Arg Val 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 4

<400>  34

Ile Leu Gly Cys Gly Arg Ala Arg Val Trp Leu Asp Pro Asn Glu Ala 
1               5                   10                  15      


Val Glu Ile Gln 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 5

<400>  35

Asp Pro Asn Glu Ala Val Glu Ile Gln Asn Ala Asn Ser Arg Lys Ser 
1               5                   10                  15      


Val Arg Lys Leu 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 6

<400>  36

Asn Ser Arg Lys Ser Val Arg Lys Leu Ile Lys Asp Gly Phe Ile Ile 
1               5                   10                  15      


Arg Lys Pro Val 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 7

<400>  37

Asp Gly Phe Ile Ile Arg Lys Pro Val Lys Val His Ser Arg Ala Arg 
1               5                   10                  15      


Trp Arg Lys Met 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 8

<400>  38

His Ser Arg Ala Arg Trp Arg Lys Met Lys Glu Ala Lys Asp Met Gly 
1               5                   10                  15      


Arg His Asn Gly 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 9

<400>  39

Ala Lys Asp Met Gly Arg His Asn Gly Val Gly Arg Arg Glu Gly Ser 
1               5                   10                  15      


Arg Glu Ala Arg 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 10

<400>  40

Arg Arg Glu Gly Ser Arg Glu Ala Arg Met Pro Ser Lys Glu Leu Trp 
1               5                   10                  15      


Met Arg Arg Leu 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 11

<400>  41

Ser Lys Glu Leu Trp Met Arg Arg Leu Arg Ile Leu Arg Arg Leu Leu 
1               5                   10                  15      


Arg Lys Tyr Arg 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 12

<400>  42

Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp Lys Lys Ile Asp Arg 
1               5                   10                  15      


His Val Tyr Arg 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 13

<400>  43

Lys Lys Ile Asp Arg His Val Tyr Arg Asp Leu Tyr Met Arg Ala Lys 
1               5                   10                  15      


Gly Asn Val Phe 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 14

<400>  44

Tyr Met Arg Ala Lys Gly Asn Val Phe Arg Asn Lys Arg Asn Leu Val 
1               5                   10                  15      


Glu His Ile His 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 15

<400>  45

Lys Arg Asn Leu Val Glu His Ile His Lys Ile Lys Asn Glu Lys Lys 
1               5                   10                  15      


Lys Glu Arg Gln 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 16

<400>  46

Lys Asn Glu Lys Lys Lys Glu Arg Gln Leu Ala Glu Gln Leu Ala Ala 
1               5                   10                  15      


Lys His Leu Arg 
            20  


<210>  47
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 17

<400>  47

Glu Gln Leu Ala Ala Lys His Leu Arg Asp Glu Gln Asn Arg Asn Lys 
1               5                   10                  15      


Ala Arg Lys Gln 
            20  


<210>  48
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 18

<400>  48

Gln Asn Arg Asn Lys Ala Arg Lys Gln Glu Leu Lys Lys Arg Glu Lys 
1               5                   10                  15      


Glu Arg Glu Arg 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 19

<400>  49

Lys Lys Arg Glu Lys Glu Arg Glu Arg Ala Arg Arg Asp Asp Ala Ala 
1               5                   10                  15      


Ala Ala Ala Gln 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 20

<400>  50

Arg Asp Asp Ala Ala Ala Ala Ala Gln Lys Lys Lys Ala Asp Ala Ala 
1               5                   10                  15      


Lys Lys Ser Ala 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 21

<400>  51

Lys Ala Asp Ala Ala Lys Lys Ser Ala Ala Pro Ala Ala Lys Ser Ala 
1               5                   10                  15      


Ala Pro Ala Ala 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 22

<400>  52

Ala Ala Lys Ser Ala Ala Pro Ala Ala Lys Ala Ala Ala Pro Ala Thr 
1               5                   10                  15      


Lys Ala Ala Ala 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  peptide 23

<400>  53

Ala Ala Pro Ala Thr Lys Ala Ala Ala Ala Ala Pro Ala Thr Lys Gly 
1               5                   10                  15      


Ala Ala Pro Val 
            20  


<210>  54
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  peptide 24

<400>  54

Pro Ala Thr Lys Gly Ala Ala Pro Val Lys Lys Ser Lys Lys 
1               5                   10                  


<210>  55
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  peptide 1-2

<400>  55

Met Thr Pro Leu Ser Leu Ser Ser Ser Arg His Ser Phe Lys Gln Asn 
1               5                   10                  15      


Glu Thr Gln Asn Met Val Ser Leu Lys Leu Gln Ala Arg Leu Ala 
            20                  25                  30      


<210>  56
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  peptide 12-13-14

<400>  56

Leu Arg Arg Leu Leu Arg Lys Tyr Arg Ala Asp Lys Lys Ile Asp Arg 
1               5                   10                  15      


His Val Tyr Arg Asp Leu Tyr Met Arg Ala Lys Gly Asn Val Phe Arg 
            20                  25                  30          


Asn Lys Arg Asn Leu Val Glu His Ile His 
        35                  40          


<210>  57
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  peptide 23-24

<400>  57

Ala Ala Pro Ala Thr Lys Ala Ala Ala Ala Ala Pro Ala Thr Lys Gly 
1               5                   10                  15      


Ala Ala Pro Val Lys Lys Ser Lys Lys 
            20                  25  


