                         SEQUENCE LISTING

<110>  Tian, Hui
       Kaplan, Daniel David
       Zhang, Jun
       Deato, Maria
 
<120>  METHODS OF MODULATING PLA2G12A LEVELS AND TREATING DISORDERS 
       ASSOCIATED THEREWITH

<130>  NGMB-01181WO

<150>  61/481,436
<151>  2011-05-02

<150>  61/481,439
<151>  2011-05-02

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 
                85                  90                  95      


Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 
            100                 105                 110         


Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 
        115                 120                 125             


Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 
    130                 135                 140                 


Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 
145                 150                 155                 160 


Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 
                165                 170                 175     


Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 


<210>  2
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  2

Met Val Thr Pro Arg Pro Ala Pro Ala Arg Ser Pro Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Thr Ala Arg Gly Gln Glu Gln Asp Gln Thr Thr 
            20                  25                  30          


Asp Trp Arg Ala Thr Leu Lys Thr Ile Arg Asn Gly Ile His Lys Ile 
        35                  40                  45              


Asp Thr Tyr Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly 
    50                  55                  60                  


Leu Cys Gln Tyr Lys Cys Ser Asp Gly Ser Lys Pro Val Pro Arg Tyr 
65                  70                  75                  80  


Gly Tyr Lys Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly 
                85                  90                  95      


Val His Leu Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln 
            100                 105                 110         


His Asp Arg Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp 
        115                 120                 125             


Glu Glu Phe Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys 
    130                 135                 140                 


Thr Leu Gly Leu Ser Gln Asn Val Gln Ala Cys Glu Thr Thr Val Glu 
145                 150                 155                 160 


Leu Leu Phe Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp 
                165                 170                 175     


Ser Gln Arg Ala Ala Cys Trp Cys Arg Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 190         


<210>  3
<211>  197
<212>  PRT
<213>  Gallus gallus

<400>  3

Ser Ser Gly Met Ala Arg Ala Leu Leu Leu Leu Pro Leu Leu Met Ala 
1               5                   10                  15      


Gly Ala Trp Val Gly Pro Arg Pro Pro Ala Ala Arg Ser Gln Glu Ala 
            20                  25                  30          


Pro Gln Thr Pro Asp Trp Arg Met Thr Met Lys Thr Ile Arg Asn Gly 
        35                  40                  45              


Val His Lys Ile Asp Val Tyr Leu Asn Ala Ala Leu Asp Leu Leu Gly 
    50                  55                  60                  


Gly Glu Asp Gly Leu Cys Gln Tyr Lys Cys Ser Asp Gly Ser Lys Pro 
65                  70                  75                  80  


Phe Pro Arg Tyr Gly Tyr Lys Pro Ser Pro Pro Ser Gly Cys Cys Gly 
                85                  90                  95      


Ser Pro Leu Phe Gly Val His Phe Asp Val Gly Ile Pro Leu Met Thr 
            100                 105                 110         


Lys Cys Cys Asn His His Asp Arg Cys Tyr Asp Thr Cys Gly Asn Lys 
        115                 120                 125             


Lys Asn Asp Cys Asp Glu Gln Phe Gln Ser Cys Leu Ser Lys Ile Cys 
    130                 135                 140                 


Arg Asp Val Gln Lys Thr Leu Gly Ile Ser Glu Asn Val Gln Ala Cys 
145                 150                 155                 160 


Glu Ser Ile Val Gln Leu Leu Phe Asp Ala Val Ile His Leu Gly Cys 
                165                 170                 175     


Lys Pro Tyr Leu Asp Ser Gln Arg Ala Ser Cys Met Cys Arg Tyr Glu 
            180                 185                 190         


Asp Lys Thr Asp Leu 
        195         


<210>  4
<211>  186
<212>  PRT
<213>  Fish

<400>  4

Arg Pro Ser Leu Asn Leu Leu Val Phe Leu Ala Leu Leu Arg Tyr Val 
1               5                   10                  15      


Ser Ala Cys Lys His Glu Pro Glu Thr Pro Asp Trp Arg Met Thr Leu 
            20                  25                  30          


Lys Thr Ile Arg Asn Gly Ile His Arg Ile Asp Thr Tyr Leu Asn Ala 
        35                  40                  45              


Ala Leu Asp Leu Phe Gly Gly Asp Asp Gly Leu Cys His Tyr Arg Cys 
    50                  55                  60                  


Ser Asp Gly Tyr Lys Pro Ile Pro Arg Pro Gly Tyr Lys His Ser Pro 
65                  70                  75                  80  


Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Phe Gln Phe Asp Ile Gly 
                85                  90                  95      


Ile Pro Ser Met Thr Lys Cys Cys Asn Gln His Asp Arg Cys Tyr Asp 
            100                 105                 110         


Thr Cys Gly Arg Glu Lys His Asp Cys Asp Asp Gln Phe Gln Asp Cys 
        115                 120                 125             


Leu Glu Thr Ile Cys Arg Asn Val Gln Arg Thr Leu Gly Leu Ser Gln 
    130                 135                 140                 


Ser Val Gln Ala Cys Glu Ser Ala Val Ala Leu Leu Phe Asp Ala Val 
145                 150                 155                 160 


Met His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg Glu Ser Cys 
                165                 170                 175     


Val Cys His Tyr Glu Val Lys Arg Glu Leu 
            180                 185     


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)

<400>  5

Gly Ser Gly Gly Ser 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)

<400>  6

Gly Gly Gly Ser 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  7

Gly Gly Ser Gly 
1               


<210>  8
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  8

Gly Gly Ser Gly Gly 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  9

Gly Ser Gly Ser Gly 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  10

Gly Ser Gly Gly Gly 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Gly Gly Ser Gly 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  12

Gly Ser Ser Ser Gly 
1               5   


<210>  13
<211>  579
<212>  DNA
<213>  Mus musculus

<400>  13
atggtgactc cgcggcccgc gcccgcccgg ggccccgcgc tcctcctcct cctgctgctg       60

gccactgcgc gcgggcagga acaggaccag accaccgact ggagggccac cctcaagacc      120

atccgcaacg gcatccacaa gatagacacg tacctcaacg ccgcgctgga cctgctgggc      180

ggggaggacg ggctctgcca gtacaagtgc agcgacggat cgaagcctgt tccacgctat      240

ggatataaac catctccacc aaatggctgt ggctctccac tgtttggcgt tcatctgaac      300

ataggtatcc cttccctgac caagtgctgc aaccagcacg acagatgcta tgagacctgc      360

gggaaaagca agaacgactg tgacgaggag ttccagtact gcctctccaa gatctgcaga      420

gacgtgcaga agacgctcgg actatctcag aacgtccagg catgtgagac aacggtggag      480

ctcctctttg acagcgtcat ccatttaggc tgcaagccat acctggacag ccagcgggct      540

gcatgctggt gtcgttatga agaaaaaaca gatctataa                             579


<210>  14
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  14
atggtgactc cacgaccagc acccgcccgg                                        30


<210>  15
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  15
ttatagatct gtcttctcct cataacgaca cc                                     32


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  16
atggccctgc tctcgcgccc c                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  17
ttaaagatca gttttttctt c                                                 21


<210>  18
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  18
atggccctgc tctcgcgccc cgcgctcacc ctcctgctcc tcctcatggc cgctgttgtc       60

aggtgccagg agcaggccca gaccaccgac tggagagcca ccctgaagac catccggaac      120

ggcgttcata agatagacac gtacctgaac gccgccttgg acctcctggg aggcgaggac      180

ggtctctgcc agtataaatg cagtgacgga tctaagcctt tcccacgtta tggttataaa      240

ccctccccac cgaatggatg tggctctcca ctgtttggtg ttcatcttaa cattggtatc      300

ccttccctga caaagtgttg caaccaacac gacaggtgct atgagacctg tggcaaaagc      360

aagaatgact gtgatgaaga attccagtat tgcctctcca agatctgccg agatgtacag      420

aaaacactag gactaactca gcatgttcag gcatgtgaaa caacagtgga gctcttgttt      480

gacagtgtta tacatttagg ttgtaaacca tatctggaca gccaacgagc cgcatgcagg      540

tgtcattatg aagaaaaaac tgatctttaa                                       570


<210>  19
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Leu Asn Ile 
                85                  90                  95      


Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg Cys Tyr 
            100                 105                 110         


Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe Gln Tyr 
        115                 120                 125             


Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly Leu Thr 
    130                 135                 140                 


Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe Asp Ser 
145                 150                 155                 160 


Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg Ala Ala 
                165                 170                 175     


Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185         


