                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Roche Diagnostics GmbH
 
<120>  An antibody specifically binding to insulin-like growth factor-1

<130>  30927 WO

<150>  EP11164957
<151>  2011-05-05

<150>  EP12155742
<151>  2012-02-16

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  2
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Thr Gly Tyr Gly Ser Ser Ser Arg 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Gly Tyr Gly Ser Ser Ser Arg 
1               5               


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  6

Gly Gly Gly Ser 
1               


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  purification tag

<400>  7

Gly Ser Arg Lys His His His His His His His His 
1               5                   10          


<210>  8
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12-IGF-1 fusion polypeptide

<400>  8

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Ala Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Gly Gly Gly Ser Asn Lys Pro Thr Gly Tyr Gly Ser 
                85                  90                  95      


Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Gly Ser Thr Leu Val Phe 
            100                 105                 110         


Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Gly Ser Arg Lys His His 
        115                 120                 125             


His His His His His His 
    130                 


<210>  9
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlyD/FKBP12-IGF-1 fusion polypeptide

<400>  9

Met Lys Val Ala Lys Asp Leu Val Val Ser Leu Ala Tyr Gln Val Arg 
1               5                   10                  15      


Thr Glu Asp Gly Val Leu Val Asp Glu Ser Pro Val Ser Ala Pro Leu 
            20                  25                  30          


Asp Tyr Leu His Gly His Gly Ser Leu Ile Ser Gly Leu Glu Thr Ala 
        35                  40                  45              


Leu Glu Gly His Glu Val Gly Asp Lys Phe Asp Val Ala Val Gly Ala 
    50                  55                  60                  


Asn Asp Ala Tyr Gly Gln Tyr Asp Glu Asn Leu Val Gln Arg Val Pro 
65                  70                  75                  80  


Lys Asp Val Phe Met Gly Val Asp Glu Leu Gln Val Gly Met Arg Phe 
                85                  90                  95      


Leu Ala Glu Thr Asp Gln Gly Pro Val Pro Val Glu Ile Thr Ala Val 
            100                 105                 110         


Glu Asp Asp His Val Val Val Asp Gly Asn His Met Leu Ala Gly Gln 
        115                 120                 125             


Asn Leu Lys Phe Asn Val Glu Val Val Ala Ile Arg Glu Ala Thr Glu 
    130                 135                 140                 


Glu Glu Leu Ala His Gly His Val His Gly Ala His Asp His His His 
145                 150                 155                 160 


Asp His Asp His Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Val Gln Val 
            180                 185                 190         


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
        195                 200                 205             


Thr Ala Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
    210                 215                 220                 


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
225                 230                 235                 240 


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
                245                 250                 255     


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Gly 
            260                 265                 270         


Gly Gly Ser Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala 
        275                 280                 285             


Pro Gln Thr Gly Gly Gly Gly Ser Thr Leu Val Phe Asp Val Glu Leu 
    290                 295                 300                 


Leu Lys Leu Glu Gly Gly Gly Ser Arg Lys His His His His His His 
305                 310                 315                 320 


His His 
        


<210>  10
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thermus Thermophilus-SlyD-IGF-1 fusion polypeptide

<400>  10

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
65                  70                  75                  80  


Arg Arg Ala Pro Gln Thr Gly Gly Ala Gly Lys Asp Leu Asp Phe Gln 
                85                  90                  95      


Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu His 
            100                 105                 110         


Gly His Ala His Gly Gly Gly Ser Arg Lys His His His His His His 
        115                 120                 125             


His His 
    130 


<210>  11
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thermus Thermophilus-SlyD wild type  polypeptide

<400>  11

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Asp Pro Glu Gly Val Gln Val Val Pro Leu Ser 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Ala Glu Val Val Pro Gly Ala Gln Phe Tyr Ala 
                85                  90                  95      


Gln Asp Met Glu Gly Asn Pro Met Pro Leu Thr Val Val Ala Val Glu 
            100                 105                 110         


Gly Glu Glu Val Thr Val Asp Phe Asn His Pro Leu Ala Gly Lys Asp 
        115                 120                 125             


Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu 
    130                 135                 140                 


Glu Leu Leu His Gly His Ala His Gly Gly Gly Ser Arg Lys His His 
145                 150                 155                 160 


His His His His His His 
                165     


<210>  12
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thermus thermophilus SlyD-?IF fusion polypeptide

<400>  12

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Gly Ala Gly Ser Gly Ser Ser Gly Ala Gly Lys 
65                  70                  75                  80  


Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro 
                85                  90                  95      


Glu Glu Leu Leu His Gly His Ala His Gly Gly Gly Ser Arg Lys His 
            100                 105                 110         


His His His His His His His 
        115                 


<210>  13
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  native SlyD from Thermococcus gammatolerans comprising a 
       C-teminal amino acid sequence tag of SEQ ID NO: 16

<400>  13

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Arg Glu Asp Leu Ile Val Pro Val Pro Ile Glu 
                85                  90                  95      


Gln Phe Thr Ser Ala Gly Leu Glu Pro Val Glu Gly Met Tyr Val Met 
            100                 105                 110         


Thr Asp Ala Gly Ile Ala Lys Ile Leu Lys Val Glu Glu Lys Thr Val 
        115                 120                 125             


Arg Leu Asp Phe Asn His Pro Leu Ala Gly Lys Thr Ala Ile Phe Glu 
    130                 135                 140                 


Ile Glu Val Val Glu Ile Lys Lys Ala Gly Glu Ala Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Lys His His His His His His 
                165             


<210>  14
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thermococcus gammadurans SlyD-IGF-2(53-65) fusion polypeptide

<400>  14

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Gly Ser Arg Val Ser Arg Arg Ser Arg Gly Gly 
                85                  90                  95      


Ala Gly Lys Thr Ala Ile Phe Glu Ile Glu Val Val Glu Ile Lys Lys 
            100                 105                 110         


Ala Gly Glu Ala Gly Gly Gly Ser Arg Lys His His His His His His 
        115                 120                 125             


His His 
    130 


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Gly Asp Tyr Tyr Gly Lys Asp Tyr 
1               5                   


<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn His Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  17

Ser Tyr Trp Met Asn 
1               5   


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

His His Ser Asn Glu Leu Pro His Thr 
1               5                   


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Leu Val Ser Asn Arg Glu Ser 
1               5           


<210>  20
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  20

Lys Ala Thr Lys Ser Leu Leu Asn Thr Asp Gly Tyr Thr Tyr Met His 
1               5                   10                  15      


<210>  21
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn His Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Asp Tyr Tyr Gly Lys Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  22
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Ile Val Leu Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Met Gly 
1               5                   10                  15      


Gln Lys Ala Thr Ile Ser Tyr Lys Ala Thr Lys Ser Leu Leu Asn Thr 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Asn Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


Asn Thr Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys His His Ser 
                85                  90                  95      


Asn Glu Leu Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  23

Ile Gly Tyr Tyr Gly Met Asp Tyr 
1               5               


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Tyr Gly Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  25

Asn Leu Trp Met Asn 
1               5   


<210>  26
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  26

Phe Gln Ser Asn Tyr Leu Pro Thr 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  27

Leu Val Ser Asn Arg Phe Ser 
1               5           


<210>  28
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  28

Lys Ser Thr Lys Ser Leu Leu Ser Ser Asp Gly Leu Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  29
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Leu 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Tyr Gly Asp Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ser Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Gly Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  30

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Glu Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Ser Ser 
            20                  25                  30          


Asp Gly Leu Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  31
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Leu 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Tyr Gly Asp Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ser Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Gly Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Glu Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Ser Ser 
            20                  25                  30          


Asp Gly Leu Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Tyr Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Phe Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  47

Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  52

Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile Val 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile Val Asp 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile Val Asp Glu 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile Val Asp Glu Cys 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Arg Arg Ala Pro Gln Thr Gly Gly Ile Val Asp Glu Cys Cys 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  57

Arg Arg Ala Pro Gln Thr Gly Gly Ile Val Asp Glu Cys Cys Phe 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Arg Ala Pro Gln Thr Gly Gly Ile Val Asp Glu Cys Cys Phe Arg 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Pro Gln Thr Gly Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Pro Gln Thr Gly Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Thr Gly Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  62

Thr Gly Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg 
1               5                   10                  15  


