                               SEQUENCE LISTING

<110> UNIVERSITY OF WASHINGTON
 
<120> THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS

<130> RSN-000

<140> PCT/US2012/035614
<141> 2012-04-27

<150> 61/617,241
<151> 2012-03-29

<150> 61/480,961
<151> 2011-04-29

<160> 126   

<170> PatentIn version 3.5

<210> 1
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
gttaagcttg ccaccatggg tctggagaag tccctcattc tg                          42


<210> 2
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
gataccaccg gtagggaatc tgcagcacag aagtttcag                              39


<210> 3
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
ggctcgagca cagtagcatc aaagtggact ggtacgtagg                             40


<210> 4
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
aaatctagac ctcaaccagg tagggaatct gcagcacaga agtttcag                    48


<210> 5
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
tctagactat cacacagtag catcaaagtg gactggtacg tag                         43


<210> 6
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
tgtccaccgt gtccagcacc tgaactcctg ggtggatcgt cagtcttcc                   49


<210> 7
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
agatctcgag cccaaatctt ctgacaaaac tcacacatgt ccaccgtgt                   49


<210> 8
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tctagattat catttacccg gagacagaga gaggctcttc tgcgtgtagt g                51


<210> 9
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
cctccatgca aatgcccagc acctaacctc ttgggtggat catccgtctt catcttcc         58


<210> 10
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
gaagatctcg agcccagagg tcccacaatc aagccctctc ctcca                       45


<210> 11
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
gtttctagat tatcatttac ccggagtccg agagaagctc ttagtcgt                    48


<210> 12
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
agatctcgag cccaaatctt ctgacaaaac tcacacatgt ccaccgtgt                   49


<210> 13
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gttttctcga tggaggctgg gagggctttg ttggagacc                              39


<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
aaggtctcca acaaagccct cccagcctcc atcgagaaaa caatctcc                    48


<210> 15
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
tctagattat catttacccg gagacagaga gaggctcttc tgcgtgtagt g                51


<210> 16
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gttaccggtc tgaagatcgc agccttcaac atccag                                 36


<210> 17
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gttctcgaga tctttcagca tcacctccac tggatagtg                              39


<210> 18
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gttgatatcc tgaagatcgc agccttcaac atccag                                 36


<210> 19
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gtttctagat tatcacttca gcatcacctc cactggatag tg                          42


<210> 20
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
tctccaccga gcccagcacc tgaactcctg ggaggatcgt cagtcttcct cttccccc         58


<210> 21
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
agatctcgag cccaaatctt ctgacaaaac tcacacatct ccaccgagcc cagcacct         58


<210> 22
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gtctccaaca aagccctccc agcctccatc gagaaaacca tctcca                      46


<210> 23
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tggagatggt tttctcgatg ggggctggga gggctttgtt ggagacc                     47


<210> 24
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tctagattat cattttcccg gagagagaga gaggctcttc tgcgtgtagt g                51


<210> 25
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tctccaccga gcccagcacc tgaactcctg ggaggatcgt cagtcttcct cttccccc         58


<210> 26
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
agatctcgag cccaaatctt ctgacaaaac tcacacatct ccaccgagcc cagcacct         58


<210> 27
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
tggagatggt tttctcgatg ggggctggga gggctttgtt ggagacc                     47


<210> 28
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
tctagattat cattttcccg gagagagaga gaggctcttc tgcgtgtagt g                51


<210> 29
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gatatcctgc acgctagggc tgctcacatt                                        30


<210> 30
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct accggtctcg ag                                                82


<210> 31
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg gctcaggtgg       60

tggaggatct ggaggaggtg ggagtaccgg tctcgag                                97


<210> 32
<211> 91
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg gctcaggtgg       60

tggaggatct ggaggaggtg ggagtctcga g                                      91


<210> 33
<211> 462
<212> DNA
<213> Homo sapiens

<400> 33
gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatcccttcc       60

ctgggcaagg aatcccgggc caagaaattc cagcggcagc atatggactc agacagttcc      120

cccagcagca gctccaccta ctgtaaccaa atgatgaggc gccggaatat gacacagggg      180

cggtgcaaac cagtgaacac ctttgtgcac gagcccctgg tagatgtcca gaatgtctgt      240

ttccaggaaa aggtcacctg caagaacggg cagggcaact gctacaagag caactccagc      300

atgcacatca cagactgccg cctgacaaac gactccaggt accccaactg tgcataccgg      360

accagcccga aggagagaca catcattgtg gcctgtgaag ggagcccata tgtgccagtc      420

cactttgatg cttctgtgga ggactctacc taataatcta ga                         462


<210> 34
<211> 798
<212> DNA
<213> Homo sapiens

<400> 34
gatatcctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcag gaacgacacc ttcaaccgag agccattcat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaagtgat aatctaga                                                    798


<210> 35
<211> 798
<212> DNA
<213> Homo sapiens

<400> 35
gatatcctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccagccat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaaatgat aatctaga                                                    798


<210> 36
<211> 798
<212> DNA
<213> Homo sapiens

<400> 36
gatatcctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccattcat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttagagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaagtgat aatctaga                                                    798


<210> 37
<211> 795
<212> DNA
<213> Homo sapiens

<400> 37
accggtctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcag gaacgacacc ttcaaccgag agccattcat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaaagatc tcgag                                                       795


<210> 38
<211> 795
<212> DNA
<213> Homo sapiens

<400> 38
accggtctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccagccat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaaagatc tcgag                                                       795


<210> 39
<211> 795
<212> DNA
<213> Homo sapiens

<400> 39
accggtctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat       60

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      120

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      180

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      240

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      300

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccattcat tgtcaggttc      360

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      420

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      480

ggcttagagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      540

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      600

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      660

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      720

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      780

ctgaaagatc tcgag                                                       795


<210> 40
<211> 715
<212> DNA
<213> Homo sapiens

<400> 40
agatctcgag cccaaatctt ctgacaaaac tcacacatgt ccaccgtgcc cagcacctga       60

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat      120

ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt      180

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga      240

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg      300

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga      360

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc      420

atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta      480

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac      540

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga      600

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca      660

caaccactac acgcagaaga gcctctctct gtctccgggt aaatgataat ctaga           715


<210> 41
<211> 858
<212> DNA
<213> Homo sapiens

<400> 41
gttaagcttg ccaccatgga aaccccagcg cagcttctct tcctcctgct actctggctc       60

ccagatacca ccggtctgaa gatcgcagcc ttcaacatcc agacatttgg ggagaccaag      120

atgtccaatg ccaccctcgt cagctacatt gtgcagatcc tgagccgcta tgacatcgcc      180

ctggtccagg aggtcagaga cagccacctg actgccgtgg ggaagctgct ggacaacctc      240

aatcaggatg caccagacac ctatcactac gtggtcagtg agccactggg acggaacagc      300

tataaggagc gctacctgtt cgtgtacagg cctgaccagg tgtctgcggt ggacagctac      360

tactacgatg atggctgcga gccctgcggg aacgacacct tcaaccgaga gccagccatt      420

gtcaggttct tctcccggtt cacagaggtc agggagtttg ccattgttcc cctgcatgcg      480

gccccggggg acgcagtagc cgagatcgac gctctctatg acgtctacct ggatgtccaa      540

gagaaatggg gcttggagga cgtcatgttg atgggcgact tcaatgcggg ctgcagctat      600

gtgagaccct cccagtggtc atccatccgc ctgtggacaa gccccacctt ccagtggctg      660

atccccgaca gcgctgacac cacagctaca cccacgcact gtgcctatga caggatcgtg      720

gttgcaggga tgctgctccg aggcgccgtt gttcccgact cggctcttcc ctttaacttc      780

caggctgcct atggcctgag tgaccaactg gcccaagcca tcagtgacca ctatccagtg      840

gaggtgatgc tgaagtga                                                    858


<210> 42
<211> 918
<212> DNA
<213> Homo sapiens

<400> 42
atgtcacggg agctggcccc actgctgctt ctcctcctct ccatccacag cgccctggcc       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcaagg      240

agaggcataa catacaacta tgtgattagc tctcggcttg gaagaaacac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaacagc aaaaaatctg tcactctaag gaagaaaaca      900

aagagcaaac gctcctag                                                    918


<210> 43
<211> 459
<212> DNA
<213> Homo sapiens

<400> 43
atgggtctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct actgtgtag                             459


<210> 44
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
gtcgacggcg cggccgccag ccccgtgaac gtgagcagcc ccagcgtgca ggatatc          57


<210> 45
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            20                  25          


<210> 46
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            20                  25                  30          


<210> 47
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
            20                  25                  30  


<210> 48
<211> 262
<212> PRT
<213> Homo sapiens

<400> 48
Asp Ile Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys 
            260         


<210> 49
<211> 262
<212> PRT
<213> Homo sapiens

<400> 49
Asp Ile Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys 
            260         


<210> 50
<211> 262
<212> PRT
<213> Homo sapiens

<400> 50
Asp Ile Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys 
            260         


<210> 51
<211> 265
<212> PRT
<213> Homo sapiens

<400> 51
Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys Asp Leu Glu 
            260                 265 


<210> 52
<211> 265
<212> PRT
<213> Homo sapiens

<400> 52
Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys Asp Leu Glu 
            260                 265 


<210> 53
<211> 265
<212> PRT
<213> Homo sapiens

<400> 53
Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr 
1               5                   10                  15      


Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser 
            20                  25                  30          


Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr 
        35                  40                  45              


Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr 
    50                  55                  60                  


Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
65                  70                  75                  80  


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
                85                  90                  95      


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn 
            100                 105                 110         


Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg 
        115                 120                 125             


Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala 
    130                 135                 140                 


Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp 
145                 150                 155                 160 


Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser 
                165                 170                 175     


Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro 
            180                 185                 190         


Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro 
        195                 200                 205             


Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg 
    210                 215                 220                 


Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala 
225                 230                 235                 240 


Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro 
                245                 250                 255     


Val Glu Val Met Leu Lys Asp Leu Glu 
            260                 265 


<210> 54
<211> 234
<212> PRT
<213> Homo sapiens

<400> 54
Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210> 55
<211> 150
<212> PRT
<213> Homo sapiens

<400> 55
Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile Pro Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg 
            20                  25                  30          


Gln His Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys 
        35                  40                  45              


Asn Gln Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro 
    50                  55                  60                  


Val Asn Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys 
65                  70                  75                  80  


Phe Gln Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys 
                85                  90                  95      


Ser Asn Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Asp Ser 
            100                 105                 110         


Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile 
        115                 120                 125             


Ile Val Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala 
    130                 135                 140                 


Ser Val Glu Asp Ser Thr 
145                 150 


<210> 56
<211> 280
<212> PRT
<213> Homo sapiens

<400> 56
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210> 57
<211> 305
<212> PRT
<213> Homo sapiens

<400> 57
Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210> 58
<211> 156
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210> 59
<211> 693
<212> DNA
<213> Homo sapiens

<400> 59
cccaaatctt ctgacaaaac tcacacatct ccaccgtctc cagcacctga actcctgggg       60

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct gtctccgggt aaa                                   693


<210> 60
<211> 231
<212> PRT
<213> Homo sapiens

<400> 60
Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 61
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc taccctcgag cccaaatctt ctgacaaaac tcacacatct      480

ccaccgagcc cagcacctga actcctggga ggatcgtcag tcttcctctt ccccccaaaa      540

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      600

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      660

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      720

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      780

gccctcccag cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca      840

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc      900

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag      960

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1020

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1080

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctctct ctctccggga     1140

aaatga                                                                1146


<210> 62
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
145                 150                 155                 160 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380     


<210> 63
<211> 1221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 63
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catctccacc gagcccagca cctgaactcc tgggaggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctctctc cgggaaaatg a                                               1221


<210> 64
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys 
                405     


<210> 65
<211> 2064
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga acagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggttctaccg gtctcgagcc caaatcttct gacaaaactc acacatctcc accgagccca      960

gcacctgaac tcctgggagg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1020

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1080

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1140

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1200

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1260

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1320

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1380

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1440

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1500

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1560

gctctgcaca accactacac gcagaagagc ctctctctct ctccgggaaa agtcgacgga     1620

gctagcagcc ccgtgaacgt gagcagcccc agaatgcagg atatcccttc cctgggcaag     1680

gaatcccggg ccaagaaatt ccagcggcag catatggact cagacagttc ccccagcagc     1740

agctccacct actgtaacca aatgatgagg cgccggaata tgacacaggg gcggtgcaaa     1800

ccagtgaaca cctttgtgca cgagcccctg gtagatgtcc agaatgtctg tttccaggaa     1860

aaggtcacct gcaagaacgg gcagggcaag tggtacaaga gcaactccag catgcacatc     1920

acagactgcc gcctgacaaa cggctccagg taccccaact gtgcataccg aaccagcccg     1980

aaggagagac acatcattgt ggcctgtgaa ggagcccata tgtgccagtc cactttgatg     2040

cttgctgtgg aggactctac ctaa                                            2064


<210> 66
<211> 687
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Gly 
    290                 295                 300                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
305                 310                 315                 320 


Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
                325                 330                 335     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            340                 345                 350         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        355                 360                 365             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    370                 375                 380                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
385                 390                 395                 400 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                405                 410                 415     


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            420                 425                 430         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        435                 440                 445             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    450                 455                 460                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
465                 470                 475                 480 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                485                 490                 495     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            500                 505                 510         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        515                 520                 525             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro 
    530                 535                 540                 


Val Asn Val Ser Ser Pro Arg Met Gln Asp Ile Pro Ser Leu Gly Lys 
545                 550                 555                 560 


Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser 
                565                 570                 575     


Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg 
            580                 585                 590         


Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu 
        595                 600                 605             


Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys 
    610                 615                 620                 


Lys Asn Gly Gln Gly Lys Trp Tyr Lys Ser Asn Ser Ser Met His Ile 
625                 630                 635                 640 


Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr 
                645                 650                 655     


Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ala 
            660                 665                 670         


His Met Cys Gln Ser Thr Leu Met Leu Ala Val Glu Asp Ser Thr 
        675                 680                 685         


<210> 67
<211> 2055
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 67
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catctccacc gagcccagca cctgaactcc tgggaggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctctctc cgggaaaagt cgacggagct agcagccccg tgaacgtgag cagccccaga     1260

atgcaggata tcctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg     1320

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg     1380

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat     1440

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaacagctat     1500

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac     1560

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc attcattgtc     1620

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc     1680

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag     1740

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg     1800

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc     1860

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt     1920

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag     1980

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag     2040

gtgatgctga aatga                                                      2055


<210> 68
<211> 684
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
                405                 410                 415     


Ser Ser Pro Arg Met Gln Asp Ile Leu Lys Ile Ala Ala Phe Asn Ile 
            420                 425                 430         


Gln Thr Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr 
        435                 440                 445             


Ile Val Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val 
    450                 455                 460                 


Arg Asp Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn 
465                 470                 475                 480 


Gln Asp Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly 
                485                 490                 495     


Arg Asn Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln 
            500                 505                 510         


Val Ser Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys 
        515                 520                 525             


Arg Asn Asp Thr Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser 
    530                 535                 540                 


Arg Phe Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala 
545                 550                 555                 560 


Pro Gly Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu 
                565                 570                 575     


Asp Val Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp 
            580                 585                 590         


Phe Asn Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile 
        595                 600                 605             


Arg Leu Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala 
    610                 615                 620                 


Asp Thr Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val 
625                 630                 635                 640 


Ala Gly Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro 
                645                 650                 655     


Phe Asn Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala 
            660                 665                 670         


Ile Ser Asp His Tyr Pro Val Glu Val Met Leu Lys 
        675                 680                 


<210> 69
<211> 1980
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 69
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc taccctcgag cccaaatctt ctgacaaaac tcacacatct      480

ccaccgagcc cagcacctga actcctggga ggatcgtcag tcttcctctt ccccccaaaa      540

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      600

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      660

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      720

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      780

gccctcccag cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca      840

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc      900

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag      960

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1020

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1080

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctctct ctctccggga     1140

aaagtcgacg gagctagcag ccccgtgaac gtgagcagcc ccagaatgca ggatatcctg     1200

aagatcgcag ccttcaacat ccagacattt ggggagacca agatgtccaa tgccaccctc     1260

gtcagctaca ttgtgcagat cctgagccgc tatgacatcg ccctggtcca ggaggtcaga     1320

gacagccacc tgactgccgt ggggaagctg ctggacaacc tcaatcagga tgcaccagac     1380

acctatcact acgtggtcag tgagccactg ggacggaaca gctataagga gcgctacctg     1440

ttcgtgtaca ggcctgacca ggtgtctgcg gtggacagct actactacga tgatggctgc     1500

gagccctgca ggaacgacac cttcaaccga gagccattca ttgtcaggtt cttctcccgg     1560

ttcacagagg tcagggagtt tgccattgtt cccctgcatg cggccccggg ggacgcagta     1620

gccgagatcg acgctctcta tgacgtctac ctggatgtcc aagagaaatg gggcttggag     1680

gacgtcatgt tgatgggcga cttcaatgcg ggctgcagct atgtgagacc ctcccagtgg     1740

tcatccatcc gcctgtggac aagccccacc ttccagtggc tgatccccga cagcgctgac     1800

accacagcta cacccacgca ctgtgcctat gacaggatcg tggttgcagg gatgctgctc     1860

cgaggcgccg ttgttcccga ctcggctctt ccctttaact tccaggctgc ctatggcctg     1920

agtgaccaac tggcccaagc catcagtgac cactatccag tggaggtgat gctgaaatga     1980


<210> 70
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
145                 150                 155                 160 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
    370                 375                 380                 


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Arg Met Gln Asp Ile Leu 
385                 390                 395                 400 


Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met Ser 
                405                 410                 415     


Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr Asp 
            420                 425                 430         


Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val Gly 
        435                 440                 445             


Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His Tyr 
    450                 455                 460                 


Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr Leu 
465                 470                 475                 480 


Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr Tyr 
                485                 490                 495     


Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu Pro 
            500                 505                 510         


Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe Ala 
        515                 520                 525             


Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile Asp 
    530                 535                 540                 


Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu Glu 
545                 550                 555                 560 


Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val Arg 
                565                 570                 575     


Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe Gln 
            580                 585                 590         


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His Cys 
        595                 600                 605             


Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala Val 
    610                 615                 620                 


Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly Leu 
625                 630                 635                 640 


Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu Val 
                645                 650                 655     


Met Leu Lys 
            


<210> 71
<211> 693
<212> DNA
<213> Homo sapiens

<400> 71
cccaaatctt ctgacaaaac tcacacatgt ccaccgtgcc cagcacctga actcctggga       60

ggatcgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccctatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct ctctccggga aaa                                   693


<210> 72
<211> 231
<212> PRT
<213> Homo sapiens

<400> 72
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 73
<211> 693
<212> DNA
<213> Homo sapiens

<400> 73
cccaaatctt ctgacaaaac tcacacatgt ccaccgtgcc cagcacctga actcctggga       60

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cctccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct ctctccggga aaa                                   693


<210> 74
<211> 231
<212> PRT
<213> Homo sapiens

<400> 74
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 75
<211> 693
<212> DNA
<213> Homo sapiens

<400> 75
cccaaatctt ctgacaaaac tcacacatct ccaccgagcc cagcacctga actcctggga       60

ggatcgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cctccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct ctctccggga aaa                                   693


<210> 76
<211> 231
<212> PRT
<213> Homo sapiens

<400> 76
Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 77
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 77
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc taccctcgag cccaaatctt ctgacaaaac tcacacatgt      480

ccaccgtgcc cagcacctga actcctggga ggatcgtcag tcttcctctt ccccccaaaa      540

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      600

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      660

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      720

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      780

gccctcccag cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca      840

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc      900

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag      960

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1020

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1080

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctctct ctctccggga     1140

aaatga                                                                1146


<210> 78
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380     


<210> 79
<211> 1221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 79
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catgtccacc gtgcccagca cctgaactcc tgggaggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctctctc cgggaaaatg a                                               1221


<210> 80
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys 
                405     


<210> 81
<211> 2064
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 81
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga acagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggttctaccg gtctcgagcc caaatcttct gacaaaactc acacatgtcc accgtgccca      960

gcacctgaac tcctgggagg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1020

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1080

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1140

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1200

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1260

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1320

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1380

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1440

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1500

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1560

gctctgcaca accactacac gcagaagagc ctctctctct ctccgggaaa agtcgacgga     1620

gctagcagcc ccgtgaacgt gagcagcccc agaatgcagg atatcccttc cctgggcaag     1680

gaatcccggg ccaagaaatt ccagcggcag catatggact cagacagttc ccccagcagc     1740

agctccacct actgtaacca aatgatgagg cgccggaata tgacacaggg gcggtgcaaa     1800

ccagtgaaca cctttgtgca cgagcccctg gtagatgtcc agaatgtctg tttccaggaa     1860

aaggtcacct gcaagaacgg gcagggcaag tggtacaaga gcaactccag catgcacatc     1920

acagactgcc gcctgacaaa cggctccagg taccccaact gtgcataccg aaccagcccg     1980

aaggagagac acatcattgt ggcctgtgaa ggagcccata tgtgccagtc cactttgatg     2040

cttgctgtgg aggactctac ctaa                                            2064


<210> 82
<211> 687
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Gly 
    290                 295                 300                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
305                 310                 315                 320 


Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
                325                 330                 335     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            340                 345                 350         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        355                 360                 365             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    370                 375                 380                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
385                 390                 395                 400 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                405                 410                 415     


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            420                 425                 430         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        435                 440                 445             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    450                 455                 460                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
465                 470                 475                 480 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                485                 490                 495     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            500                 505                 510         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        515                 520                 525             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro 
    530                 535                 540                 


Val Asn Val Ser Ser Pro Arg Met Gln Asp Ile Pro Ser Leu Gly Lys 
545                 550                 555                 560 


Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser 
                565                 570                 575     


Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg 
            580                 585                 590         


Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu 
        595                 600                 605             


Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys 
    610                 615                 620                 


Lys Asn Gly Gln Gly Lys Trp Tyr Lys Ser Asn Ser Ser Met His Ile 
625                 630                 635                 640 


Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr 
                645                 650                 655     


Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ala 
            660                 665                 670         


His Met Cys Gln Ser Thr Leu Met Leu Ala Val Glu Asp Ser Thr 
        675                 680                 685         


<210> 83
<211> 2055
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 83
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catgtccacc gtgcccagca cctgaactcc tgggaggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctctctc cgggaaaagt cgacggagct agcagccccg tgaacgtgag cagccccaga     1260

atgcaggata tcctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg     1320

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg     1380

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat     1440

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaacagctat     1500

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac     1560

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc attcattgtc     1620

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc     1680

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag     1740

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg     1800

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc     1860

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt     1920

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag     1980

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag     2040

gtgatgctga aatga                                                      2055


<210> 84
<211> 684
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
                405                 410                 415     


Ser Ser Pro Arg Met Gln Asp Ile Leu Lys Ile Ala Ala Phe Asn Ile 
            420                 425                 430         


Gln Thr Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr 
        435                 440                 445             


Ile Val Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val 
    450                 455                 460                 


Arg Asp Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn 
465                 470                 475                 480 


Gln Asp Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly 
                485                 490                 495     


Arg Asn Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln 
            500                 505                 510         


Val Ser Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys 
        515                 520                 525             


Arg Asn Asp Thr Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser 
    530                 535                 540                 


Arg Phe Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala 
545                 550                 555                 560 


Pro Gly Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu 
                565                 570                 575     


Asp Val Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp 
            580                 585                 590         


Phe Asn Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile 
        595                 600                 605             


Arg Leu Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala 
    610                 615                 620                 


Asp Thr Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val 
625                 630                 635                 640 


Ala Gly Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro 
                645                 650                 655     


Phe Asn Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala 
            660                 665                 670         


Ile Ser Asp His Tyr Pro Val Glu Val Met Leu Lys 
        675                 680                 


<210> 85
<211> 1980
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 85
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc taccctcgag cccaaatctt ctgacaaaac tcacacatgt      480

ccaccgtgcc cagcacctga actcctggga ggatcgtcag tcttcctctt ccccccaaaa      540

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      600

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      660

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      720

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      780

gccctcccag cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca      840

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc      900

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag      960

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1020

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1080

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctctct ctctccggga     1140

aaagtcgacg gagctagcag ccccgtgaac gtgagcagcc ccagaatgca ggatatcctg     1200

aagatcgcag ccttcaacat ccagacattt ggggagacca agatgtccaa tgccaccctc     1260

gtcagctaca ttgtgcagat cctgagccgc tatgacatcg ccctggtcca ggaggtcaga     1320

gacagccacc tgactgccgt ggggaagctg ctggacaacc tcaatcagga tgcaccagac     1380

acctatcact acgtggtcag tgagccactg ggacggaaca gctataagga gcgctacctg     1440

ttcgtgtaca ggcctgacca ggtgtctgcg gtggacagct actactacga tgatggctgc     1500

gagccctgca ggaacgacac cttcaaccga gagccattca ttgtcaggtt cttctcccgg     1560

ttcacagagg tcagggagtt tgccattgtt cccctgcatg cggccccggg ggacgcagta     1620

gccgagatcg acgctctcta tgacgtctac ctggatgtcc aagagaaatg gggcttggag     1680

gacgtcatgt tgatgggcga cttcaatgcg ggctgcagct atgtgagacc ctcccagtgg     1740

tcatccatcc gcctgtggac aagccccacc ttccagtggc tgatccccga cagcgctgac     1800

accacagcta cacccacgca ctgtgcctat gacaggatcg tggttgcagg gatgctgctc     1860

cgaggcgccg ttgttcccga ctcggctctt ccctttaact tccaggctgc ctatggcctg     1920

agtgaccaac tggcccaagc catcagtgac cactatccag tggaggtgat gctgaaatga     1980


<210> 86
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
    370                 375                 380                 


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Arg Met Gln Asp Ile Leu 
385                 390                 395                 400 


Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met Ser 
                405                 410                 415     


Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr Asp 
            420                 425                 430         


Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val Gly 
        435                 440                 445             


Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His Tyr 
    450                 455                 460                 


Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr Leu 
465                 470                 475                 480 


Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr Tyr 
                485                 490                 495     


Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu Pro 
            500                 505                 510         


Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe Ala 
        515                 520                 525             


Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile Asp 
    530                 535                 540                 


Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu Glu 
545                 550                 555                 560 


Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val Arg 
                565                 570                 575     


Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe Gln 
            580                 585                 590         


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His Cys 
        595                 600                 605             


Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala Val 
    610                 615                 620                 


Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly Leu 
625                 630                 635                 640 


Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu Val 
                645                 650                 655     


Met Leu Lys 
            


<210> 87
<211> 693
<212> DNA
<213> Homo sapiens

<400> 87
cccaaatctt ctgacaaaac tcacacatgt ccaccgtgtc cagcacctga actcctgggg       60

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct gtctccgggt aaa                                   693


<210> 88
<211> 231
<212> PRT
<213> Homo sapiens

<400> 88
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 89
<211> 693
<212> DNA
<213> Homo sapiens

<400> 89
cccaaatctt ctgacaaaac tcacacatgt ccaccgtgcc cagcacctga actcctggga       60

ggatcgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cctccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctctct ctctccggga aaa                                   693


<210> 90
<211> 231
<212> PRT
<213> Homo sapiens

<400> 90
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 91
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 91
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcctga caccaccggc       60

aaagagtccc gggccaagaa gttccagcgg cagcacatgg actccgactc cagcccttcc      120

agctcctcca cctactgcaa ccagatgatg cggcggagaa acatgaccca gggccggtgc      180

aagcccgtga acacctttgt gcacgagccc ctggtggacg tgcagaacgt gtgttttcaa      240

gagaaagtga cctgcaagaa cggccagggc aactgctaca agtccaactc ctccatgcac      300

atcaccgact gccggctgac caacggctcc agatacccca actgcgccta ccggacctcc      360

cccaaagaac ggcacatcat cgtggcctgc gagggctctc cttacgtgcc cgtgcacttc      420

gacgcctccg tggaagattc caccctggaa cccaagtcct ccgacaagac ccacacctgt      480

cccccttgtc ctgcccctga actgctgggc ggctcctccg tgttcctgtt ccccccaaag      540

cccaaggaca ccctgatgat ctcccggacc cccgaagtga catgcgtggt ggtggatgtg      600

tcccacgagg accctgaagt gaagttcaat tggtacgtgg acggggtgga agtgcacaac      660

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg      720

accgtgctgc accaggattg gctgaacgga aaagagtaca agtgcaaggt gtccaacaag      780

gccctgcccg cctccatcga aaagaccatc tccaaggcca agggccagcc ccgggaaccc      840

caggtgtaca cactgccccc tagcagggac gagctgacca agaaccaggt gtccctgacc      900

tgcctcgtga agggcttcta cccctccgat atcgccgtgg aatgggagtc caacggccag      960

cctgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1020

tactccaagc tgacagtgga caagtcccgg tggcagcagg gcaacgtgtt ctcctgctcc     1080

gtgatgcacg aggctctgca caaccactac acccagaagt ccctgtccct gagccccggc     1140

aaatga                                                                1146


<210> 92
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380     


<210> 93
<211> 1980
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 93
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

aaagagagcc gggccaagaa gttccagcgg cagcacatgg acagcgacag cagccccagc      120

agctccagca cctactgcaa ccagatgatg cggcggagaa acatgaccca gggccggtgc      180

aagcccgtga acaccttcgt gcacgagccc ctggtggacg tgcagaacgt gtgttttcaa      240

gaaaaagtga cctgcaagaa cggccagggc aactgctaca agagcaacag cagcatgcac      300

atcaccgact gccggctgac caacggcagc agatacccca actgcgccta ccggaccagc      360

cccaaagaac ggcacatcat cgtggcctgc gagggcagcc cttacgtgcc cgtgcacttt      420

gacgccagcg tggaagatag caccctggaa cccaagagca gcgacaagac ccacacctgt      480

cccccctgcc ctgcccctga gctgctgggc ggaagcagcg tgttcctgtt ccccccaaag      540

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      600

tcccacgagg accccgaagt gaagttcaat tggtacgtgg acggcgtgga agtgcacaac      660

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg      720

accgtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt ctccaacaag      780

gccctgcccg ccagcatcga gaaaaccatc agcaaggcca agggccagcc tcgcgagccc      840

caggtgtaca cactgccccc cagccgggac gagctgacca agaaccaggt gtccctgacc      900

tgcctggtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag      960

cccgagaaca actacaagac caccccccct gtgctggact ccgacggctc attcttcctg     1020

tacagcaagc tgaccgtgga caagagccgg tggcagcagg gcaacgtgtt cagctgcagc     1080

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1140

aaggtggacg gcgccagctc ccctgtgaac gtgtccagcc ccagcgtgca ggacatcctg     1200

aagatcgccg ccttcaacat ccagaccttc ggcgagacaa agatgagcaa cgccaccctg     1260

gtgtcctaca tcgtgcagat cctgagcaga tacgatatcg ccctggtgca agaagtgcgg     1320

gacagccacc tgaccgccgt gggcaagctg ctggacaacc tgaaccagga cgcccccgac     1380

acctaccact acgtggtgtc cgagcctctg ggccggaaca gctacaaaga aagatacctg     1440

ttcgtgtacc ggcccgatca ggtgtccgcc gtggacagct actactacga cgacggctgc     1500

gagccctgcc ggaacgacac cttcaaccgc gagcccttca tcgtgcggtt cttcagccgg     1560

ttcaccgaag tgcgcgagtt cgccatcgtg cccctgcatg ctgcccctgg cgacgccgtg     1620

gccgagatcg atgccctgta cgacgtgtac ctggatgtgc aagaaaagtg gggcctggaa     1680

gatgtgatgc tgatgggcga cttcaacgcc ggctgcagct acgtgcggcc cagccagtgg     1740

tccagcatca gactgtggac ctcccccacc ttccagtggc tgatccccga cagcgccgat     1800

accaccgcca cccccaccca ctgtgcctac gacagaatcg tggtggccgg catgctgctg     1860

agaggcgccg tggtgcctga cagcgccctg ccattcaatt ttcaagccgc ctacggcctg     1920

agcgatcagc tggcccaggc catcagcgac cactaccccg tggaagtgat gctgaagtga     1980


<210> 94
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
    370                 375                 380                 


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
385                 390                 395                 400 


Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met Ser 
                405                 410                 415     


Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr Asp 
            420                 425                 430         


Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val Gly 
        435                 440                 445             


Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His Tyr 
    450                 455                 460                 


Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr Leu 
465                 470                 475                 480 


Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr Tyr 
                485                 490                 495     


Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu Pro 
            500                 505                 510         


Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe Ala 
        515                 520                 525             


Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile Asp 
    530                 535                 540                 


Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu Glu 
545                 550                 555                 560 


Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val Arg 
                565                 570                 575     


Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe Gln 
            580                 585                 590         


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His Cys 
        595                 600                 605             


Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala Val 
    610                 615                 620                 


Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly Leu 
625                 630                 635                 640 


Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu Val 
                645                 650                 655     


Met Leu Lys 
            


<210> 95
<211> 1086
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 95
aaagagtccc gggccaagaa gttccagcgg cagcacatgg actccgactc cagcccttcc       60

agctcctcca cctactgcaa ccagatgatg cggcggagaa acatgaccca gggccggtgc      120

aagcccgtga acacctttgt gcacgagccc ctggtggacg tgcagaacgt gtgttttcaa      180

gagaaagtga cctgcaagaa cggccagggc aactgctaca agtccaactc ctccatgcac      240

atcaccgact gccggctgac caacggctcc agatacccca actgcgccta ccggacctcc      300

cccaaagaac ggcacatcat cgtggcctgc gagggctctc cttacgtgcc cgtgcacttc      360

gacgcctccg tggaagattc caccctggaa cccaagtcct ccgacaagac ccacacctgt      420

cccccttgtc ctgcccctga actgctgggc ggctcctccg tgttcctgtt ccccccaaag      480

cccaaggaca ccctgatgat ctcccggacc cccgaagtga catgcgtggt ggtggatgtg      540

tcccacgagg accctgaagt gaagttcaat tggtacgtgg acggggtgga agtgcacaac      600

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg      660

accgtgctgc accaggattg gctgaacgga aaagagtaca agtgcaaggt gtccaacaag      720

gccctgcccg cctccatcga aaagaccatc tccaaggcca agggccagcc ccgggaaccc      780

caggtgtaca cactgccccc tagcagggac gagctgacca agaaccaggt gtccctgacc      840

tgcctcgtga agggcttcta cccctccgat atcgccgtgg aatgggagtc caacggccag      900

cctgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg      960

tactccaagc tgacagtgga caagtcccgg tggcagcagg gcaacgtgtt ctcctgctcc     1020

gtgatgcacg aggctctgca caaccactac acccagaagt ccctgtccct gagccccggc     1080

aaatga                                                                1086


<210> 96
<211> 361
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360     


<210> 97
<211> 1920
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 97
aaagagagcc gggccaagaa gttccagcgg cagcacatgg acagcgacag cagccccagc       60

agctccagca cctactgcaa ccagatgatg cggcggagaa acatgaccca gggccggtgc      120

aagcccgtga acaccttcgt gcacgagccc ctggtggacg tgcagaacgt gtgttttcaa      180

gaaaaagtga cctgcaagaa cggccagggc aactgctaca agagcaacag cagcatgcac      240

atcaccgact gccggctgac caacggcagc agatacccca actgcgccta ccggaccagc      300

cccaaagaac ggcacatcat cgtggcctgc gagggcagcc cttacgtgcc cgtgcacttt      360

gacgccagcg tggaagatag caccctggaa cccaagagca gcgacaagac ccacacctgt      420

cccccctgcc ctgcccctga gctgctgggc ggaagcagcg tgttcctgtt ccccccaaag      480

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      540

tcccacgagg accccgaagt gaagttcaat tggtacgtgg acggcgtgga agtgcacaac      600

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg      660

accgtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt ctccaacaag      720

gccctgcccg ccagcatcga gaaaaccatc agcaaggcca agggccagcc tcgcgagccc      780

caggtgtaca cactgccccc cagccgggac gagctgacca agaaccaggt gtccctgacc      840

tgcctggtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag      900

cccgagaaca actacaagac caccccccct gtgctggact ccgacggctc attcttcctg      960

tacagcaagc tgaccgtgga caagagccgg tggcagcagg gcaacgtgtt cagctgcagc     1020

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1080

aaggtggacg gcgccagctc ccctgtgaac gtgtccagcc ccagcgtgca ggacatcctg     1140

aagatcgccg ccttcaacat ccagaccttc ggcgagacaa agatgagcaa cgccaccctg     1200

gtgtcctaca tcgtgcagat cctgagcaga tacgatatcg ccctggtgca agaagtgcgg     1260

gacagccacc tgaccgccgt gggcaagctg ctggacaacc tgaaccagga cgcccccgac     1320

acctaccact acgtggtgtc cgagcctctg ggccggaaca gctacaaaga aagatacctg     1380

ttcgtgtacc ggcccgatca ggtgtccgcc gtggacagct actactacga cgacggctgc     1440

gagccctgcc ggaacgacac cttcaaccgc gagcccttca tcgtgcggtt cttcagccgg     1500

ttcaccgaag tgcgcgagtt cgccatcgtg cccctgcatg ctgcccctgg cgacgccgtg     1560

gccgagatcg atgccctgta cgacgtgtac ctggatgtgc aagaaaagtg gggcctggaa     1620

gatgtgatgc tgatgggcga cttcaacgcc ggctgcagct acgtgcggcc cagccagtgg     1680

tccagcatca gactgtggac ctcccccacc ttccagtggc tgatccccga cagcgccgat     1740

accaccgcca cccccaccca ctgtgcctac gacagaatcg tggtggccgg catgctgctg     1800

agaggcgccg tggtgcctga cagcgccctg ccattcaatt ttcaagccgc ctacggcctg     1860

agcgatcagc tggcccaggc catcagcgac cactaccccg tggaagtgat gctgaagtga     1920


<210> 98
<211> 639
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro 
        355                 360                 365             


Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Lys Ile Ala Ala 
    370                 375                 380                 


Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu 
385                 390                 395                 400 


Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val 
                405                 410                 415     


Gln Glu Val Arg Asp Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp 
            420                 425                 430         


Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu 
        435                 440                 445             


Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg 
    450                 455                 460                 


Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys 
465                 470                 475                 480 


Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu Pro Phe Ile Val Arg 
                485                 490                 495     


Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu 
            500                 505                 510         


His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp 
        515                 520                 525             


Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu 
    530                 535                 540                 


Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp 
545                 550                 555                 560 


Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro 
                565                 570                 575     


Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg 
            580                 585                 590         


Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser 
        595                 600                 605             


Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu 
    610                 615                 620                 


Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu Val Met Leu Lys 
625                 630                 635                 


<210> 99
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 99
Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile 
        


<210> 100
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 100
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr 
            


<210> 101
<211> 128
<212> PRT
<213> Homo sapiens

<400> 101
Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210> 102
<211> 260
<212> PRT
<213> Homo sapiens

<400> 102
Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys 
            260 


<210> 103
<211> 285
<212> PRT
<213> Homo sapiens

<400> 103
Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly Glu Ser Lys Gln 
1               5                   10                  15      


Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val Ile Lys Arg Cys 
            20                  25                  30          


Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn Asn Arg Ile Cys 
        35                  40                  45              


Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg Arg Gly Ile Thr 
    50                  55                  60                  


Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn Thr Tyr Lys Glu 
65                  70                  75                  80  


Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser Val Lys Arg Ser 
                85                  90                  95      


Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp Val Phe Ser Arg 
            100                 105                 110         


Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr Ala Val Lys Asp 
        115                 120                 125             


Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr Ser Val Lys Glu 
    130                 135                 140                 


Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys His Arg Trp Lys 
145                 150                 155                 160 


Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr 
                165                 170                 175     


Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg Thr Asp Pro Arg 
            180                 185                 190         


Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr Val Lys Lys Ser 
        195                 200                 205             


Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly Gln Glu Ile Val 
    210                 215                 220                 


Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp Phe Gln Lys Ala 
225                 230                 235                 240 


Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser Asp His Phe Pro 
                245                 250                 255     


Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr Asn Ser Lys Lys 
            260                 265                 270         


Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg Ser 
        275                 280                 285 


<210> 104
<211> 369
<212> PRT
<213> Homo sapiens

<400> 104
Met Gly Pro Gly Ala Arg Arg Gln Gly Arg Ile Val Gln Gly Arg Pro 
1               5                   10                  15      


Glu Met Cys Phe Cys Pro Pro Pro Thr Pro Leu Pro Pro Leu Arg Ile 
            20                  25                  30          


Leu Thr Leu Gly Thr His Thr Pro Thr Pro Cys Ser Ser Pro Gly Ser 
        35                  40                  45              


Ala Ala Gly Thr Tyr Pro Thr Met Gly Ser Gln Ala Leu Pro Pro Gly 
    50                  55                  60                  


Pro Met Gln Thr Leu Ile Phe Phe Asp Met Glu Ala Thr Gly Leu Pro 
65                  70                  75                  80  


Phe Ser Gln Pro Lys Val Thr Glu Leu Cys Leu Leu Ala Val His Arg 
                85                  90                  95      


Cys Ala Leu Glu Ser Pro Pro Thr Ser Gln Gly Pro Pro Pro Thr Val 
            100                 105                 110         


Pro Pro Pro Pro Arg Val Val Asp Lys Leu Ser Leu Cys Val Ala Pro 
        115                 120                 125             


Gly Lys Ala Cys Ser Pro Ala Ala Ser Glu Ile Thr Gly Leu Ser Thr 
    130                 135                 140                 


Ala Val Leu Ala Ala His Gly Arg Gln Cys Phe Asp Asp Asn Leu Ala 
145                 150                 155                 160 


Asn Leu Leu Leu Ala Phe Leu Arg Arg Gln Pro Gln Pro Trp Cys Leu 
                165                 170                 175     


Val Ala His Asn Gly Asp Arg Tyr Asp Phe Pro Leu Leu Gln Ala Glu 
            180                 185                 190         


Leu Ala Met Leu Gly Leu Thr Ser Ala Leu Asp Gly Ala Phe Cys Val 
        195                 200                 205             


Asp Ser Ile Thr Ala Leu Lys Ala Leu Glu Arg Ala Ser Ser Pro Ser 
    210                 215                 220                 


Glu His Gly Pro Arg Lys Ser Tyr Ser Leu Gly Ser Ile Tyr Thr Arg 
225                 230                 235                 240 


Leu Tyr Gly Gln Ser Pro Pro Asp Ser His Thr Ala Glu Gly Asp Val 
                245                 250                 255     


Leu Ala Leu Leu Ser Ile Cys Gln Trp Arg Pro Gln Ala Leu Leu Arg 
            260                 265                 270         


Trp Val Asp Ala His Ala Arg Pro Phe Gly Thr Ile Arg Pro Met Tyr 
        275                 280                 285             


Gly Val Thr Ala Ser Ala Arg Thr Lys Pro Arg Pro Ser Ala Val Thr 
    290                 295                 300                 


Thr Thr Ala His Leu Ala Thr Thr Arg Asn Thr Ser Pro Ser Leu Gly 
305                 310                 315                 320 


Glu Ser Arg Gly Thr Lys Asp Leu Pro Pro Val Lys Asp Pro Gly Ala 
                325                 330                 335     


Leu Ser Arg Glu Gly Leu Leu Ala Pro Leu Gly Leu Leu Ala Ile Leu 
            340                 345                 350         


Thr Leu Ala Val Ala Thr Leu Tyr Gly Leu Ser Leu Ala Thr Pro Gly 
        355                 360                 365             


Glu 
    


<210> 105
<211> 297
<212> PRT
<213> Homo sapiens

<400> 105
Met Gly Pro Gly Ala Arg Arg Gln Gly Arg Ile Val Gln Gly Arg Pro 
1               5                   10                  15      


Glu Met Cys Phe Cys Pro Pro Pro Thr Pro Leu Pro Pro Leu Arg Ile 
            20                  25                  30          


Leu Thr Leu Gly Thr His Thr Pro Thr Pro Cys Ser Ser Pro Gly Ser 
        35                  40                  45              


Ala Ala Gly Thr Tyr Pro Thr Met Gly Ser Gln Ala Leu Pro Pro Gly 
    50                  55                  60                  


Pro Met Gln Thr Leu Ile Phe Phe Asp Met Glu Ala Thr Gly Leu Pro 
65                  70                  75                  80  


Phe Ser Gln Pro Lys Val Thr Glu Leu Cys Leu Leu Ala Val His Arg 
                85                  90                  95      


Cys Ala Leu Glu Ser Pro Pro Thr Ser Gln Gly Pro Pro Pro Thr Val 
            100                 105                 110         


Pro Pro Pro Pro Arg Val Val Asp Lys Leu Ser Leu Cys Val Ala Pro 
        115                 120                 125             


Gly Lys Ala Cys Ser Pro Ala Ala Ser Glu Ile Thr Gly Leu Ser Thr 
    130                 135                 140                 


Ala Val Leu Ala Ala His Gly Arg Gln Cys Phe Asp Asp Asn Leu Ala 
145                 150                 155                 160 


Asn Leu Leu Leu Ala Phe Leu Arg Arg Gln Pro Gln Pro Trp Cys Leu 
                165                 170                 175     


Val Ala His Asn Gly Asp Arg Tyr Asp Phe Pro Leu Leu Gln Ala Glu 
            180                 185                 190         


Leu Ala Met Leu Gly Leu Thr Ser Ala Leu Asp Gly Ala Phe Cys Val 
        195                 200                 205             


Asp Ser Ile Thr Ala Leu Lys Ala Leu Glu Arg Ala Ser Ser Pro Ser 
    210                 215                 220                 


Glu His Gly Pro Arg Lys Ser Tyr Ser Leu Gly Ser Ile Tyr Thr Arg 
225                 230                 235                 240 


Leu Tyr Gly Gln Ser Pro Pro Asp Ser His Thr Ala Glu Gly Asp Val 
                245                 250                 255     


Leu Ala Leu Leu Ser Ile Cys Gln Trp Arg Pro Gln Ala Leu Leu Arg 
            260                 265                 270         


Trp Val Asp Ala His Ala Arg Pro Phe Gly Thr Ile Arg Pro Met Tyr 
        275                 280                 285             


Gly Val Thr Ala Ser Ala Arg Thr Lys 
    290                 295         


<210> 106
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
145                 150                 155                 160 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                165                 170                 175     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        195                 200                 205             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    210                 215                 220                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                245                 250                 255     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            260                 265                 270         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        275                 280                 285             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    290                 295                 300                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
305                 310                 315                 320 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                325                 330                 335     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            340                 345                 350         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        355                 360                 365             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380         


<210> 107
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 107
Val Asp Gly Ala Ala Ala Ser Pro Val Asn Val Ser Ser Pro Ser Val 
1               5                   10                  15      


Gln Asp Ile 
            


<210> 108
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 108
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 109
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(25)
<223> This sequence may encompass 0-5 "Gly-Gly-Gly-Gly-Ser" 
      repeating units

<400> 109
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 110
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 111
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(50)
<223> This sequence may encompass 1-10 "Gly-Gly-Gly-Gly-Ser" 
      repeating units

<400> 111
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 112
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 112
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 113
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 113
Ser Gly Gly Gly Gly Ser 
1               5       


<210> 114
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 114
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210> 115
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 115
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 116
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 116
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210> 117
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 117
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210> 118
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30      


<210> 119
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210> 120
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40      


<210> 121
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45      


<210> 122
<211> 51
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


<210> 123
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(25)
<223> This sequence may encompass 3-5 "Gly-Gly-Gly-Gly-Ser" 
      repeating units

<400> 123
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 124
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(25)
<223> This sequence may encompass 1-5 "Gly-Gly-Gly-Gly-Ser" 
      repeating units

<400> 124
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 125
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 125
Gly Gly Gly Gly Ser 
1               5   


<210> 126
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(18)
<223> This sequence may encompass 12-18 nucleotides

<400> 126
tttttttttt tttttttt                                                     18


