                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
	 Molecular Partners AG
       Baumann, Michael
       Jacobs, Steven
       O'Neil, Karyn
       Sennhauser, Gaby
 
<120>  IL4/IL13 Binding Repeat Proteins and Uses

<130>  CEN5310PCT

<140>  To Be Assigned
<141>  2012-04-16

<150>  61/480999
<151>  2011-04-29

<150>  61/481008
<151>  2011-04-29

<150>  61/481021
<151>  2011-04-29

<160>  179   

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, D, E, F, H, I, K, L, M, N, Q, R, 
	S, T, V, W or Y

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Wherein Xaa can be A, D, E, F, H, I, K, L, M, N, Q, R, 
	S, T, V, W or Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223> Wherein Xaa can be A, D, E, F, H, I, K, L, M, N, Q, R, 
	S, T, V, W or Y

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Wherein Xaa can be A, D, E, F, H, I, K, L, M, N, Q, R, 
	S, T, V, W or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  1

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap

<400>  2

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210>  3
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap

<400>  3

Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
1               5                   10                  15      


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
            20                  25              


<210>  4
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  4

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  129
<212>  PRT
<213>  Cynomolgus

<400>  5

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Lys Leu Thr Ile Thr Asp Ile 
            20                  25                  30          


Leu Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  6
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His 
    


<210>  7
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


<210>  8
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln Pro Pro Val Thr Asn 
1               5                   10                  15      


Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val Ile Trp Thr Trp Asn 
            20                  25                  30          


Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu Trp Tyr Phe Ser His 
        35                  40                  45              


Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro Glu Thr Arg Arg Ser 
    50                  55                  60                  


Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu Gln Val Gly Ser Gln 
65                  70                  75                  80  


Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile Leu Val Glu Lys Cys 
                85                  90                  95      


Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala Val Thr Glu Leu Gln 
            100                 105                 110         


Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys Ser Trp Leu Pro Gly 
        115                 120                 125             


Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu Tyr Tyr Trp His Arg 
    130                 135                 140                 


Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile Phe Arg Glu Gly Gln 
145                 150                 155                 160 


Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val Lys Asp Ser Ser Phe 
                165                 170                 175     


Glu Gln His Ser Val Gln Ile Met Val Lys Asp Asn Ala Gly Lys Ile 
            180                 185                 190         


Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser Arg Val Lys Pro Asp 
        195                 200                 205             


Pro Pro His Ile Lys Asn Leu Ser Phe His Asn Asp Asp Leu Tyr Val 
    210                 215                 220                 


Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg Cys Leu Phe Tyr Glu 
225                 230                 235                 240 


Val Glu Val Asn Asn Ser Gln Thr Glu Thr His Asn Val Phe Tyr Val 
                245                 250                 255     


Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu Arg Asn Val Glu Asn 
            260                 265                 270         


Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro Asp Thr Leu Asn Thr 
        275                 280                 285             


Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys Tyr Glu Asp Asp Lys 
    290                 295                 300                 


Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile Gly Lys Lys Arg Asn 
305                 310                 315                 320 


Ser Thr 
        


<210>  9
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  9

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Val Ser Asp 
            20                  25                  30          


Arg Ile Gly Asn Thr Pro Leu His Leu Ala Ala Val Tyr Val His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Leu 
    50                  55                  60                  


Asp Asp Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Thr Asp Ser His Val Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  10
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  10

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ile Asp 
            20                  25                  30          


Glu Trp Gly Asp Thr Pro Leu His Leu Ala Ala Ile Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  


Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  11
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  11

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ile 
    50                  55                  60                  


Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  12
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  12

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  


Asp Ser Gln Gly Leu Thr Pro Leu His Leu Ala Ala Tyr Tyr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Asn Asp His His Gly Ile Thr Pro Leu His Leu Ala Ala Phe Ala Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  13
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  13

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Val Asp 
            20                  25                  30          


His Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  


Asp Asn Phe Gly Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Gln Thr Gly Leu Thr Pro Leu His Leu Ala Ala Val Asp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  14
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  14

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Tyr Asp 
            20                  25                  30          


Ser Ser Gly Asp Thr Pro Leu His Val Ala Ala Ile Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  


Asp Ala Ser Gly Asp Thr Pro Leu His Leu Ala Ala Asp Phe Gly His 
65                  70                  75                  80  


Leu Lys Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Glu Asp Met Ile Gly Ile Thr Pro Leu His Leu Ala Ala Tyr Asn Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Ser Asp Val His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
    130                 135                 140                 


Gly His Leu Gly Ile Val Glu Val Leu Leu Lys Tyr Asp Ala Asp Val 
145                 150                 155                 160 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
                165                 170                 175     


Asn Arg Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
            180                 185                 190 


<210>  15
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  15

Asp Leu Gly Lys Glu Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Val Asp 
            20                  25                  30          


His Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  


Asp Asn Phe Gly Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Gln Thr Gly Leu Thr Pro Leu His Leu Ala Ala Val Asp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  16
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  16

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          


Asp Ser Gly Ile Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  


Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Trp Thr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Tyr Asp Ile Ser Gly Ile Thr Pro Leu His Leu Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  17
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  17

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Val Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Ala Trp Gly Leu Thr Pro Leu His Leu Ala Ala Leu Leu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala His 
    50                  55                  60                  


Asp Glu Thr Gly Phe Thr Pro Leu His Leu Ala Ala Val Glu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Asn Phe Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  18
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  18

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Val Asp 
            20                  25                  30          


His Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  


Asp Asn Phe Gly Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Lys Asp Gln Thr Gly Leu Thr Pro Leu His Leu Ala Ala Val Asp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  19
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  19

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          


Val Thr Gly Glu Thr Pro Leu His Leu Ala Ser Trp Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  


Asp Leu Phe Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr Asp Gly 
65                  70                  75                  80  


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Thr Asp Ser Asn Gly Phe Thr Pro Leu His Leu Ala Ala Ser Tyr 
            100                 105                 110         


Gly His Leu Glu Ile Val Asp Val Leu Leu Lys Asn Gly Ala Asp Val 
        115                 120                 125             


Asn Ala His Asp Phe Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ser 
    130                 135                 140                 


Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
145                 150                 155                 160 


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
                165                 170                 175     


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
            180                 185                 190     


<210>  20
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  20

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Met Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  21
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  21

Asp Leu Gly Lys Glu Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Met 
    50                  55                  60                  


Asp Asn Ile Gly Asn Thr Ser Leu His Leu Ala Ala Phe Asp Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  22
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  22

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Phe Asp 
            20                  25                  30          


Asp Ser Gly Leu Thr Pro Leu His Leu Ala Ala Asp Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Met Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  23
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  23

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Ala Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ile 
    50                  55                  60                  


Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  24
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  24

Asp Leu Gly Lys Glu Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp 
            20                  25                  30          


Lys Asp Gly Ser Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  


Asp Met Asn Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asp Ala 
                85                  90                  95      


Lys Asp Arg Thr Gly Trp Thr Pro Leu His Leu Ala Gly Glu Phe Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  25
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  25

Asn Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Asn 
    50                  55                  60                  


Asp Ala Ile Gly Asp Thr Pro Leu His Leu Ala Ala Leu Tyr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Thr Asp Leu His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Trp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  26
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  26

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ile 
    50                  55                  60                  


Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Thr Ala Phe Ser Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  27
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  27

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ile Asp 
            20                  25                  30          


Ser Asp Gly Thr Thr Pro Leu His Leu Ala Ala Met Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Val 
    50                  55                  60                  


Asp Trp Asn Gly Asp Thr Pro Leu His Leu Ala Ala Val Asp Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Gln Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Ser Asp Phe His Gly Ile Thr Pro Leu His Leu Ala Ala Phe Ser 
    130                 135                 140                 


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
145                 150                 155                 160 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
                165                 170                 175     


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
            180                 185                 190 


<210>  28
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  28

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala His Asp 
            20                  25                  30          


Asn Ser Gly Phe Thr Pro Leu His Leu Ala Ala Glu Ile Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Met Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  29
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  29

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Glu Asp 
            20                  25                  30          


Asp Trp Gly Leu Thr Pro Leu His Leu Ala Ala Met Leu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Asp Thr Gly Phe Thr Pro Leu His Leu Ala Ala Val Glu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Asn Phe Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  30
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  30

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Ala Trp Gly Leu Thr Pro Leu His Leu Ala Ala Leu Leu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala His 
    50                  55                  60                  


Asp Glu Thr Gly Phe Thr Pro Leu His Leu Ala Ala Val Glu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Asn Phe Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  31

Ser Asp Arg Ile Gly Asn Thr Pro Leu His Leu Ala Ala Val Tyr Val 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  32

Ile Asp Glu Trp Gly Asp Thr Pro Leu His Leu Ala Ala Ile Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  33
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  33

Thr Asp Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  34
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  34

Val Asp His Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  35

Tyr Asp Ser Ser Gly Asp Thr Pro Leu His Val Ala Ala Ile Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  36
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  36

Ala Asp Asp Ser Gly Ile Thr Pro Leu His Leu Ala Ala Glu Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  37

Thr Asp Ala Trp Gly Leu Thr Pro Leu His Leu Ala Ala Leu Leu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  38
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  38

Lys Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ser Trp Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  39
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  39

Leu Asp Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  40
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  40

Phe Asp Asp Ser Gly Leu Thr Pro Leu His Leu Ala Ala Asp Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  41
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  41

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
            180                 185                 190         


Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
        195                 200                 205             


Ala Arg Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu 
    210                 215                 220                 


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
225                 230                 235                 240 


Asn Ala Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr 
                245                 250                 255     


Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
            260                 265                 270         


Val Asn Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala 
        275                 280                 285             


Gln Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala 
    290                 295                 300                 


Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
305                 310                 315                 320 


Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
                325                 330                 335     


<210>  42
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  42

Ser Asp Lys Asp Gly Ser Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  43
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  43

Thr Asp Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  44
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  44

Ile Asp Ser Asp Gly Thr Thr Pro Leu His Leu Ala Ala Met Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  45
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  45

His Asp Asn Ser Gly Phe Thr Pro Leu His Leu Ala Ala Glu Ile Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  46
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  46

Glu Asp Asp Trp Gly Leu Thr Pro Leu His Leu Ala Ala Met Leu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  47
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  47

Leu Asp Asp Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  48
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  48

Ser Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
1               5                   10                  15      


Tyr Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  49
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  49

Ile Asp Ala Met Gly Met Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
1               5                   10                  15      


Tyr Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  50
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  50

Ser Asp Ser Gln Gly Leu Thr Pro Leu His Leu Ala Ala Tyr Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  51
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  51

Asp Asp Asn Phe Gly Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  52
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  52

Ser Asp Ala Ser Gly Asp Thr Pro Leu His Leu Ala Ala Asp Phe Gly 
1               5                   10                  15      


His Leu Lys Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  53
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  53

Gln Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  54
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  54

His Asp Glu Thr Gly Phe Thr Pro Leu His Leu Ala Ala Val Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  55
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  55

Gln Asp Leu Phe Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr Asp 
1               5                   10                  15      


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
            20                  25                  30          


Asn Ala 
        


<210>  56
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  56

Ala Asp Arg Met Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  57
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  57

Met Asp Asn Ile Gly Asn Thr Ser Leu His Leu Ala Ala Phe Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  58
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  58

Glu Asp Met Asn Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asp 
            20                  25                  30          


Ala 
    


<210>  59
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  59

Asn Asp Ala Ile Gly Asp Thr Pro Leu His Leu Ala Ala Leu Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  60
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  60

Val Asp Trp Asn Gly Asp Thr Pro Leu His Leu Ala Ala Val Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  61
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  61

Lys Asp Asp Thr Gly Phe Thr Pro Leu His Leu Ala Ala Val Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  62
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  62

Thr Asp Ser His Val Trp Thr Pro Leu His Leu Ala Ala Phe Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  63
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  63

Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  64
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  64

Asn Asp His His Gly Ile Thr Pro Leu His Leu Ala Ala Phe Ala Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  65
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  65

Lys Asp Gln Thr Gly Leu Thr Pro Leu His Leu Ala Ala Val Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  66
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  66

Glu Asp Met Ile Gly Ile Thr Pro Leu His Leu Ala Ala Tyr Asn Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  67
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  67

Lys Asp Gln Thr Gly Leu Thr Pro Leu His Leu Ala Ala Val Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  68
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  68

Tyr Asp Ile Ser Gly Ile Thr Pro Leu His Leu Ala Ala Phe Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  69
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  69

Ser Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Asn Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  70
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  70

Thr Asp Ser Asn Gly Phe Thr Pro Leu His Leu Ala Ala Ser Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Asp Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  71
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  71

Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  72
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  72

Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  73
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  73

Lys Asp Arg Thr Gly Trp Thr Pro Leu His Leu Ala Gly Glu Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  74

Thr Asp Leu His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Trp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  75
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  75

Met Asp Phe Ser Gly Phe Thr Pro Leu His Leu Thr Ala Phe Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  76
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  76

Gln Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  77
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  77

Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  78
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  78

Ser Asp Ile Leu Gly Arg Thr Pro Leu His Leu Ala Ala Asn Phe Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  79
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  79

Ser Asp Phe His Gly Ile Thr Pro Leu His Leu Ala Ala Phe Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  80
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  80

Ser Asp Val His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly 
1               5                   10                  15      


His Leu Gly Ile Val Glu Val Leu Leu Lys Tyr Asp Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  81
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  81

His Asp Phe Asp Gly Phe Thr Pro Leu His Leu Ala Ala Ser Trp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  82
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be T, V, I, S, A, V, or H

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be D, F, L, I, N, E, Y, or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  82

Xaa Asp Asp Trp Gly Xaa Thr Pro Leu His Leu Ala Ala Thr Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  83
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be S, I, D, Q, A, E, H, K, N, or V

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be A, D, E, L, M, N, S, or W

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be D, F, I, L, M, N, Q, S, or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be D, M, L, F, I, or Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherein Xaa can be A, D, F, L, V, or Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be D, E, F, T, V, W, or Y
<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  83

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  84
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be M, K, V, E, N, T, S, or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be F, H, I, L, M, N, Q, R, or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be A, H, I, L, N, S, or T

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherein Xaa can be E, F, N, S, V or Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be A, D, F, I, N, S, or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  84

Xaa Asp Xaa Xaa Gly Phe Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  85
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be D, F, L, I, N, E, Y, or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  85

Thr Asp Asp Trp Gly Xaa Thr Pro Leu His Leu Ala Ala Thr Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  86
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, D, E, H, I, K, N, Q, or V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be D, F, I, L, M, or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  86

Xaa Asp Ala Met Gly Xaa Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  87
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be E, K, M, N, T, S, V or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be F, H, I, L, M, N, Q, R, S, or V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be A, H, I, L, N, S, or T
<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y


<400>  87

Xaa Asp Xaa Xaa Gly Phe Thr Pro Leu His Leu Ala Ala Phe Tyr
1                5                  10                  15      


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp 
                20                  25                  30
 
Val Asn Ala               
                      


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, L, or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be S or W

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be D, I, or Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherien Xaa can be E or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be A or H

<400>  88

Xaa Asp Asp Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Asp Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  89
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, N or Q

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be A, N, or R

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be I or L

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherein Xaa can be F, L, or W

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be T, V, or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be A or Y

<400>  89

Xaa Asp Xaa Xaa Gly Asp Thr Pro Leu His Leu Ala Ala Xaa Xaa  
1               5                   10                  15       


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val  
                 20                  25                  30 

Asn Ala           


<210>  90
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be T, V, or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be I or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be A, H, or S

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein Xaa can be F, I, or V

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be W or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be A or H

<400>  90

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Phe Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  91
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  91

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  92
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  92

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          


Asp Ser Gly Ile Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  


Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Trp Thr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Tyr Asp Ile Ser Gly Ile Thr Pro Leu His Leu Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  93
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  93

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Asn 
    50                  55                  60                  


Asp Ala Ile Gly Asp Thr Pro Leu His Leu Ala Ala Leu Tyr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Thr Asp Leu His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Trp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  94
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  94

Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  95
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  95

Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
            180                 185                 190         


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
        195                 200                 205             


Ala Asp Asp Ser Gly Ile Thr Pro Leu His Leu Ala Ala Glu Asp Gly 
    210                 215                 220                 


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 


Ala Gln Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Trp Thr 
                245                 250                 255     


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         


Asn Ala Tyr Asp Ile Ser Gly Ile Thr Pro Leu His Leu Ala Ala Phe 
        275                 280                 285             


Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
    290                 295                 300                 


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
305                 310                 315                 320 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 335 


<210>  96
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  96

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          


Asp Ser Gly Ile Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  


Asp Asn Leu Gly Asp Thr Pro Leu His Leu Ala Ala Trp Thr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Tyr Asp Ile Ser Gly Ile Thr Pro Leu His Leu Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
            180                 185                 190         


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg 
        195                 200                 205             


Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
    210                 215                 220                 


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
225                 230                 235                 240 


Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
                245                 250                 255     


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            260                 265                 270         


Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile 
        275                 280                 285             


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    290                 295                 300                 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
305                 310                 315                 320 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 


<210>  97
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  97

Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp 
            180                 185                 190         


Asp Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu 
        195                 200                 205             


Asp Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His 
    210                 215                 220                 


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
225                 230                 235                 240 


Ala Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly 
                245                 250                 255     


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            260                 265                 270         


Ala Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr 
        275                 280                 285             


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    290                 295                 300                 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
305                 310                 315                 320 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 


<210>  98
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  98

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val His Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
            180                 185                 190         


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg 
        195                 200                 205             


Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
    210                 215                 220                 


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
225                 230                 235                 240 


Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
                245                 250                 255     


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            260                 265                 270         


Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile 
        275                 280                 285             


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    290                 295                 300                 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
305                 310                 315                 320 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 


<210>  99
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  99

Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
            180                 185                 190         


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr 
        195                 200                 205             


Asp Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His 
    210                 215                 220                 


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
225                 230                 235                 240 


Asn Asp Ala Ile Gly Asp Thr Pro Leu His Leu Ala Ala Leu Tyr Gly 
                245                 250                 255     


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            260                 265                 270         


Ala Thr Asp Leu His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Trp 
        275                 280                 285             


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    290                 295                 300                 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
305                 310                 315                 320 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 


<210>  100
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  100

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Asp Trp Gly Asp Thr Leu Leu His Leu Ala Ala Thr Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Asn 
    50                  55                  60                  


Asp Ala Ile Gly Asp Thr Pro Leu His Leu Ala Ala Leu Tyr Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Thr Asp Leu His Gly Phe Thr Pro Leu His Leu Ala Ala Phe Trp Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
            180                 185                 190         


Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg 
        195                 200                 205             


Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
    210                 215                 220                 


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
225                 230                 235                 240 


Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
                245                 250                 255     


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            260                 265                 270         


Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile 
        275                 280                 285             


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    290                 295                 300                 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
305                 310                 315                 320 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                325                 330                 


<210>  101
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Wherein Xaa can be R or Q

<400>  101

Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu 
1               5                   10                  15      


Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met 
            20                  25                  30          


Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu 
        35                  40                  45              


Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg 
    50                  55                  60                  


Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser 
65                  70                  75                  80  


Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys 
                85                  90                  95      


Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Xaa Phe Asn 
            100                 105                 110         


<210>  102
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  102

Asp Thr Glu Ile Lys Val Asn Pro Pro Gln Asp Phe Glu Ile Val Asp 
1               5                   10                  15      


Pro Gly Tyr Leu Gly Tyr Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser 
            20                  25                  30          


Leu Asp His Phe Lys Glu Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg 
        35                  40                  45              


Asn Ile Gly Ser Glu Thr Trp Lys Thr Ile Ile Thr Lys Asn Leu His 
    50                  55                  60                  


Tyr Lys Asp Gly Phe Asp Leu Asn Lys Gly Ile Glu Ala Lys Ile His 
65                  70                  75                  80  


Thr Leu Leu Pro Trp Gln Cys Thr Asn Gly Ser Glu Val Gln Ser Ser 
                85                  90                  95      


Trp Ala Glu Thr Thr Tyr Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr 
            100                 105                 110         


Lys Val Gln Asp Met Asp Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu 
        115                 120                 125             


Cys Ser Trp Lys Pro Gly Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn 
    130                 135                 140                 


Leu Phe Tyr Trp Tyr Glu Gly Leu Asp His Ala Leu Gln Cys Val Asp 
145                 150                 155                 160 


Tyr Ile Lys Ala Asp Gly Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu 
                165                 170                 175     


Glu Ala Ser Asp Tyr Lys Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser 
            180                 185                 190         


Glu Asn Lys Pro Ile Arg Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn 
        195                 200                 205             


Ile Val Lys Pro Leu Pro Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser 
    210                 215                 220                 


Ser Cys Glu Ile Lys Leu Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro 
225                 230                 235                 240 


Ala Arg Cys Phe Asp Tyr Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr 
                245                 250                 255     


Leu Val Thr Ala Thr Val Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr 
            260                 265                 270         


Asn Glu Thr Arg Gln Leu Cys Phe Val Val Arg Ser Lys Val Asn Ile 
        275                 280                 285             


Tyr Cys Ser Asp Asp Gly Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys 
    290                 295                 300                 


Trp Glu Gly Glu Asp Leu Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu 
305                 310                 315                 320 


Pro Phe Gly Phe Ile Leu Ile Leu Val Ile Phe Val Thr Gly Leu Leu 
                325                 330                 335     


Leu Arg Lys Pro Asn Thr Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys 
            340                 345                 350         


Asp Thr 
        


<210>  103
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap

<400>  103

Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Asn Gly 
1               5                   10                  15      


His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              


<210>  104
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  104

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          


Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe Tyr Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Asn 
    130                 135                 140                 


Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
            180                 185                 190         


Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
        195                 200                 205             


Ala Arg Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu 
    210                 215                 220                 


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
225                 230                 235                 240 


Asn Ala Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr 
                245                 250                 255     


Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
            260                 265                 270         


Val Asn Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala 
        275                 280                 285             


Gln Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala 
    290                 295                 300                 


Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala 
305                 310                 315                 320 


Ala Asp Asn Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                325                 330                 335     


<210>  105
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  105

Asp Leu Gly Glu Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Tyr Asp 
            20                  25                  30          


Asp Asp Gly Met Thr Pro Leu His Leu Ala Ala Lys Ser Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Met 
    50                  55                  60                  


Asp Ile Thr Gly Ser Ala Pro Leu His Leu Ala Ala Asp Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ile Asp Tyr Leu Gly Ala Thr Pro Leu His Leu Ala Ala Thr Tyr Gly 
            100                 105                 110         


His Pro Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  106
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  106

Asp Leu Gly Glu Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Tyr Asp 
            20                  25                  30          


Asp Asp Gly Met Thr Pro Leu His Leu Ala Ala Lys Ser Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Met 
    50                  55                  60                  


Asp Ile Thr Gly Ser Ala Pro Leu His Leu Ala Ala Asp Leu Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ile Asp Tyr Leu Gly Ala Thr Pro Leu His Leu Ala Ala Thr Tyr Gly 
            100                 105                 110         


His Pro Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  107

<210>  107
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  107

Met Arg Gly Ser His His His His His His Gly Ser Asp Leu Gly Lys 
1               5                   10                  15      


Lys Leu Met Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
            20                  25                  30          


Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Leu Phe Gly Ile 
        35                  40                  45              


Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu 
    50                  55                  60                  


Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Thr Asp Asn Trp Gly 
65                  70                  75                  80  


Ser Thr Pro Leu His Leu Ala Ala Gln Phe Gly His Leu Glu Ile Val 
                85                  90                  95      


Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
            100                 105                 110         


Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
        115                 120                 125             


Ala Glu Ile Leu Gln Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Asp Leu Gly 
145                 150                 155                 160 


Glu Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                165                 170                 175     


Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Tyr Asp Asp Asp Gly 
            180                 185                 190         


Met Thr Pro Leu His Leu Ala Ala Lys Ser Gly His Leu Glu Ile Val 
        195                 200                 205             


Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Met Asp Ile Thr 
    210                 215                 220                 


Gly Ser Ala Pro Leu His Leu Ala Ala Asp Leu Gly His Leu Glu Ile 
225                 230                 235                 240 


Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Ile Asp Tyr 
                245                 250                 255     


Leu Gly Ala Thr Pro Leu His Leu Ala Ala Thr Tyr Gly His Pro Glu 
            260                 265                 270         


Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp 
        275                 280                 285             


Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu 
    290                 295                 300                 


Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
305                 310                 
 
<210>  108
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  109
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  109

Arg Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  110
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  110

Thr Asp Glu Phe Asp Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  111
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  111

Ser Asp Ile Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  112
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  112

Ile Asp His Phe Asp Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  113
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  113

Thr Asp Val Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  114
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  114

Phe Asp Asp Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  115
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  115

Glu Asp Ile Leu Gly Ile Thr Pro Leu His Leu Ala Ala His His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  116
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  116

Thr Asp Thr Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Cys 
1               5                   10                  15      


His Gln Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  117
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  117

Val Asp Asp Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Gln Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  118
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  118

Lys Asp Leu Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  119
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  119

Thr Asp Met Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  120
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  120

Trp Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  121
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  121

Ala Asp Met Tyr Gly Thr Thr Pro Gln His Leu Ala Ala Arg Thr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  122
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  122

Ser Asp Ile Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  123
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  123

Ala Asp Asp Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  124
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  124

Met Asp Lys Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  125
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  125

Phe Asp Asp Phe Gly Asp Thr Pro Leu His Leu Ala Ala Arg Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Lys Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  126
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  126

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Xaa Val Asn 
            20                  25                  30          


Ala 
    


<210>  127
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  127

Lys Asp Met Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  128
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  128

Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Cys Gly Val Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  129
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  129

Met Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  130
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  130

Asp Asp Phe Leu Gly Asp Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Asp Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  131
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  131

Thr Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  132
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  132

His Asp Met Ile Gly Asp Thr Pro Leu His Leu Ala Tyr His Glu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  133
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  133

Asn Asp Phe Ala Gly Tyr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  134
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  134

Asn Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Trp His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  135
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  135

Asn Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Trp His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  136
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  136

Glu Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  137
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  137

Phe Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  138
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  138

Lys Asp Met Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  139
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  139

Ala Asp Phe Leu Gly Asp Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  140
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  140

Asn Asp Met Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  141
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  141

Asn Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Asn Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  142
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  142

Thr Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  143
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  143

Thr Asp Ile Ile Gly Asn Thr Pro Leu His Leu Ala Ala Phe Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  144
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  144

Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  145
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  145

Asp Asp His Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Ser Met Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  146
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  146

Lys Asn Gly Glu Thr Pro Leu His Leu Ala Ala Tyr His Gly His Pro 
1               5                   10                  15      


Asp Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
            20                  25                  30      


<210>  147
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  147

Lys Asp Thr Ser Gly Thr Thr Pro Leu His Leu Ala Ala Asp Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  148
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  148

Thr Asp Ala Trp Gly Glu Thr Pro Leu His Leu Ala Ala Tyr Thr Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Asp Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  149
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  149

Met Asp Val Thr Gly Glu Thr Pro Leu His Leu Ala Ala Tyr His Gly 
1               5                   10                  15      


His Leu Asp Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  150
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  150

Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Thr Ala Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  151
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  151

Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala His Leu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  152
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  152

Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala His Asn Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  153
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  153

Thr Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Glu Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Thr 
    


<210>  154
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  154

Glu Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Glu Ser Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  155
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  155

Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala His Leu Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  156
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be T, A, F, E, I, K, M, S, R, V or W

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be D, E, H, I, K, M, S, T, or V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be F or Y

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  156

Xaa Asp Xaa Xaa Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  157
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Wherein Xaa can be H, N, or Y

<400>  157

Thr Asp Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly His 
1               5                   10                  15      


Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn Ala 
            20                  25                  30          


<210>  158
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be N, T, A, D, K, E, H, M or F

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be H or R

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  158

Xaa Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  159
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, D, N, T, or K

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be H or R

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  159

Xaa Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  160
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be D, E, K, M, S, or T

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be I, A, T or V or is absent

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherein Xaa can be D, E, H, Q, S, T, or Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be M, L, H, S, A, I, N, R, or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be H, N, or Y

<400>  160

Xaa Asp Xaa Thr Gly Glu Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  161
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  161

Xaa Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Ser Met Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  162
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  162

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  


Asp Met Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155         


<210>  163
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  163

Ala Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          


Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      


Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu Ala Ala Gln Ile Gly 
            100                 105                 110         


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             


Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 


Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         


<210>  164
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  164

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp 
            20                  25                  30          


Ile Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Met 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn Ala 
                85                  90                  95      


Asp Asp His Gly Asp Thr Pro Leu His Leu Ala Ala Ser Met Gly His 
            100                 105                 110         


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
        115                 120                 125             


Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
    130                 135                 140                 


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155     


<210>  165
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat signature

<400>  165

Gly Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp 
            20                  25                  30          


Ile Phe Gly Ser Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Phe 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn Ala 
                85                  90                  95      


Asp Asp His Gly Asp Thr Pro Leu His Leu Ala Ala Gln Ile Gly His 
            100                 105                 110         


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
        115                 120                 125             


Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
    130                 135                 140                 


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155     


<210>  166
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  166

Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Glu Phe Asp Ser Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Cys Gly Val Asp Val Asn Ala 
                85                  90                  95      


Asp Asp His Gly Asp Thr Pro Leu His Leu Ala Ala Ser Met Gly His 
            100                 105                 110         


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
        115                 120                 125             


Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
    130                 135                 140                 


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 155     


<210>  167
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  167

Gly Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          


Glu Phe Asp Ser Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  


Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly His 
65                  70                  75                  80  


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Val Asp Val Asn Ala 
                85                  90                  95      


Asp Asp His Gly Asp Thr Pro Leu His Leu Ala Ala Ser Thr Gly His 
            100                 105                 110         


Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
        115                 120                 125             


Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
    130                 135                 140                 


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155     


<210>  168
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be R, S, or T

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be S or W

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be F or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Wherein Xaa can be D or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be E or H

<400>  168

Xaa Asp Xaa Xaa Xaa Ser Thr Pro Leu His Leu Ala Ala Arg Xaa Gly His 
1                5                   10                  15      


Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
         20                  25                  30          


<210>  169
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A or F

<400>  169

Xaa Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala Ala Tyr Arg Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  170
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be D or S

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be H or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa can be G or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherien Xaa can be D or S

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Wherein Xaa can be Q or S


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Wherein Xaa can be I or T

<400>  170

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  171
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin consensus cap


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be A, D, or G

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa can be D or G

<400>  171

Xaa Leu Xaa Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30  


<210>  172
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap

<400>  172

Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Asn Gly 
1               5                   10                  15      


His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              


<210>  173
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  173

Gly Ser Asp Leu Gly Lys Lys Leu Met Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Leu Phe Gly Ile Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Asn Trp Gly Ser Thr Pro Leu His Leu Ala Ala Gln Phe 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
        115                 120                 125     


<210>  174
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be D or G

<400>  174

Xaa Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
1               5                   10                  15      


Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25              


<210>  175
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat cap


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Wherein Xaa can be A or P

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Wherein Xaa can be A or F

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Wherein Xaa can be A or S

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Wherein Xaa can be A or I

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Wherein Xaa can be H or N

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Wherein Xaa can be I or L

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Wherein Xaa can be I or V

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Wherein Xaa can be A or L

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Wherein Xaa can be A or N


<400>  175

Gln Asp Lys Phe Gly Lys Thr Xaa Xaa Asp Ile Xaa Xaa Asp Asn Gly 
1               5                   10                  15      


Xaa Glu Asp Xaa Ala Glu Xaa Leu Gln Lys Xaa Xaa 
            20                  25              


<210>  176
<211>  1017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  176
atgggatccg acctgggtaa gaaactgctg gaagctgctc gtgctggtca ggacgacgaa      60

gttcgtatcc tgatggctaa cggtgctgac gttaacgctc tggatgatag cggttataca     120

ccgctgcatc tggcagcgga agatggtcat ctggaaattg ttgaagttct gctgaaacac     180

ggtgccgatg tgaatgccgc agatcgtctg ggtgatactc cgctgcatct ggctgccttt     240

gttggccatc tggaaatcgt agaggtgctg ctgaaagcag gcgcagatgt aaacgcagtt     300

gatctggcag gcgttacccc tctgcacgtt gcagcatttt atggacactt agaaattgtg     360

gaggtactgc tgaaggcagg tgcagacgtt aacgcacagg ataaatttgg taaaaccccg     420

gcggatattg cggcggataa tggccatgag gatattgcag aagtgctgca aaaggcggcg     480

ggcggcggtg gctctggcgg tggtggctct ggcggtggcg gttctggcgg tggtggctct      540

ggatccgacc tggataagaa actgctggaa gcagcacgtg caggtcagga tgatgaagtt      600

cgtattctga tggcaaatgg cgccgatgtt aatgcacgtg atagctatgg tagcacaccg      660

ctgcatctgg ctgcacgtga gggtcatctg gaaattgtgg aagtgctgct gaaatacggt      720

gccgatgtga atgccgcaga ttttattggt gataccccgt tacatctggc tgcgtatcgt      780

ggccatttag aaatcgtgga ggttctgtta aaatacggcg cagacgttaa tgcaagcgat      840

attaccggtg aaacccctct gcatttagca gcgcagattg gccacctgga aatcgtcgaa      900

gttttactga aacatggcgc agatgttaac gcacaggata aatttggtaa aaccccggcg      960

gatattgcgg cggataatgg ccatgaggat attgcagaag tgctgcagaa ggcggcg        1017


<210>  177
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  177

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ala Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe 
            100                 105                 110         


Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala 
    130                 135                 140                 


Asp Asn Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Arg Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 


Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala 
225                 230                 235                 240 


Asp Val Asn Ala Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala 
                245                 250                 255     


Ala Tyr Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly 
            260                 265                 270         


Ala Asp Val Asn Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu 
        275                 280                 285             


Ala Ala Gln Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His 
    290                 295                 300                 


Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp 
305                 310                 315                 320 


Ile Ala Ala Asp Asn Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
                325                 330                 335     


Ala Ala 
        


<210>  178
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ankyrin repeat sequence

<400>  178

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Ser Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Asp Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Glu Asp Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ala Asp Arg Leu Gly Asp Thr Pro Leu His Leu Ala Ala Phe Val 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Leu Ala Gly Val Thr Pro Leu His Val Ala Ala Phe 
            100                 105                 110         


Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Arg Asp Ser Tyr Gly Ser Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 


Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala 
225                 230                 235                 240 


Asp Val Asn Ala Ala Asp Phe Ile Gly Asp Thr Pro Leu His Leu Ala 
                245                 250                 255     


Ala Tyr Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly 
            260                 265                 270         


Ala Asp Val Asn Ala Ser Asp Ile Thr Gly Glu Thr Pro Leu His Leu 
        275                 280                 285             


Ala Ala Gln Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His 
    290                 295                 300                 


Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
                325                 330                 335     


Ala Ala 

<210>  179
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus ankyrin repeat sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa can be D, E, K, M, S, or T


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Wherein Xaa can be D, E, H, Q, S, T, or Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Wherein Xaa can be M, L, H, S, A, I, N, R, or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Wherein Xaa can be H, N, or Y

<400>  179

Xaa Asp Thr Gly Glu Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
                20                  25                  30          


Ala 
    

 
        


