                         SEQUENCE LISTING

<110>  Chen, Che-Hong
       Mochly-Rosen, Daria
       Le, Quynh-Thu
 
<120>  Compositions and Methods for Increasing Proliferation of Adult 
       Salivary Stem Cells

<130>  STAN-813WO

<150>  61/480,506
<151>  2011-04-29

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Ser Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  2
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  3
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Lys Ile Ser Glu Ala Val Lys Arg Ala Pro Ala Ala Phe Ser 
1               5                   10                  15      


Ser Gly Arg Thr Arg Pro Leu Gln Phe Arg Ile Gln Gln Leu Glu Ala 
            20                  25                  30          


Leu Gln Arg Leu Ile Gln Glu Gln Glu Gln Glu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Asp Leu His Lys Asn Glu Trp Asn Ala Tyr Tyr Glu Glu Val 
    50                  55                  60                  


Val Tyr Val Leu Glu Glu Ile Glu Tyr Met Ile Gln Lys Leu Pro Glu 
65                  70                  75                  80  


Trp Ala Ala Asp Glu Pro Val Glu Lys Thr Pro Gln Thr Gln Gln Asp 
                85                  90                  95      


Glu Leu Tyr Ile His Ser Glu Pro Leu Gly Val Val Leu Val Ile Gly 
            100                 105                 110         


Thr Trp Asn Tyr Pro Phe Asn Leu Thr Ile Gln Pro Met Val Gly Ala 
        115                 120                 125             


Ile Ala Ala Gly Asn Ser Val Val Leu Lys Pro Ser Glu Leu Ser Glu 
    130                 135                 140                 


Asn Met Ala Ser Leu Leu Ala Thr Ile Ile Pro Gln Tyr Leu Asp Lys 
145                 150                 155                 160 


Asp Leu Tyr Pro Val Ile Asn Gly Gly Val Pro Glu Thr Thr Glu Leu 
                165                 170                 175     


Leu Lys Glu Arg Phe Asp His Ile Leu Tyr Thr Gly Ser Thr Gly Val 
            180                 185                 190         


Gly Lys Ile Ile Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Ser Pro Cys Tyr Val Asp Lys Asn Cys Asp 
    210                 215                 220                 


Leu Asp Val Ala Cys Arg Arg Ile Ala Trp Gly Lys Phe Met Asn Ser 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Ile Leu Cys Asp Pro Ser Ile 
                245                 250                 255     


Gln Asn Gln Ile Val Glu Lys Leu Lys Lys Ser Leu Lys Glu Phe Tyr 
            260                 265                 270         


Gly Glu Asp Ala Lys Lys Ser Arg Asp Tyr Gly Arg Ile Ile Ser Ala 
        275                 280                 285             


Arg His Phe Gln Arg Val Met Gly Leu Ile Glu Gly Gln Lys Val Ala 
    290                 295                 300                 


Tyr Gly Gly Thr Gly Asp Ala Ala Thr Arg Tyr Ile Ala Pro Thr Ile 
305                 310                 315                 320 


Leu Thr Asp Val Asp Pro Gln Ser Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Val Leu Pro Ile Val Cys Val Arg Ser Leu Glu Glu Ala Ile 
            340                 345                 350         


Gln Phe Ile Asn Gln Arg Glu Lys Pro Leu Ala Leu Tyr Met Phe Ser 
        355                 360                 365             


Ser Asn Asp Lys Val Ile Lys Lys Met Ile Ala Glu Thr Ser Ser Gly 
    370                 375                 380                 


Gly Val Ala Ala Asn Asp Val Ile Val His Ile Thr Leu His Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Asn Ser Gly Met Gly Ser Tyr His Gly Lys 
                405                 410                 415     


Lys Ser Phe Glu Thr Phe Ser His Arg Arg Ser Cys Leu Val Arg Pro 
            420                 425                 430         


Leu Met Asn Asp Glu Gly Leu Lys Val Arg Tyr Pro Pro Ser Pro Ala 
        435                 440                 445             


Lys Met Thr Gln His 
    450             


<210>  4
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Ala Asn Gly Ala Val Glu Asn Gly Gln Pro Asp Gly Lys 
1               5                   10                  15      


Pro Pro Ala Leu Pro Arg Pro Ile Arg Asn Leu Glu Val Lys Phe Thr 
            20                  25                  30          


Lys Ile Phe Ile Asn Asn Glu Trp His Glu Ser Lys Ser Gly Lys Lys 
        35                  40                  45              


Phe Ala Thr Cys Asn Pro Ser Thr Arg Glu Gln Ile Cys Glu Val Glu 
    50                  55                  60                  


Glu Gly Asp Lys Pro Asp Val Asp Lys Ala Val Glu Ala Ala Gln Val 
65                  70                  75                  80  


Ala Phe Gln Arg Gly Ser Pro Trp Arg Arg Leu Asp Ala Leu Ser Arg 
                85                  90                  95      


Gly Arg Leu Leu His Gln Leu Ala Asp Leu Val Glu Arg Asp Arg Ala 
            100                 105                 110         


Thr Leu Ala Ala Leu Glu Thr Met Asp Thr Gly Lys Pro Phe Leu His 
        115                 120                 125             


Ala Phe Phe Ile Asp Leu Glu Gly Cys Ile Arg Thr Leu Arg Tyr Phe 
    130                 135                 140                 


Ala Gly Trp Ala Asp Lys Ile Gln Gly Lys Thr Ile Pro Thr Asp Asp 
145                 150                 155                 160 


Asn Val Val Cys Phe Thr Arg His Glu Pro Ile Gly Val Cys Gly Ala 
                165                 170                 175     


Ile Thr Pro Trp Asn Phe Pro Leu Leu Met Leu Val Trp Lys Leu Ala 
            180                 185                 190         


Pro Ala Leu Cys Cys Gly Asn Thr Met Val Leu Lys Pro Ala Glu Gln 
        195                 200                 205             


Thr Pro Leu Thr Ala Leu Tyr Leu Gly Ser Leu Ile Lys Glu Ala Gly 
    210                 215                 220                 


Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly Phe Gly Pro Thr Val 
225                 230                 235                 240 


Gly Ala Ala Ile Ser Ser His Pro Gln Ile Asn Lys Ile Ala Phe Thr 
                245                 250                 255     


Gly Ser Thr Glu Val Gly Lys Leu Val Lys Glu Ala Ala Ser Arg Ser 
            260                 265                 270         


Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Asn Pro Cys Ile 
        275                 280                 285             


Val Cys Ala Asp Ala Asp Leu Asp Leu Ala Val Glu Cys Ala His Gln 
    290                 295                 300                 


Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Ala Ser Arg Val 
305                 310                 315                 320 


Phe Val Glu Glu Gln Val Tyr Ser Glu Phe Val Arg Arg Ser Val Glu 
                325                 330                 335     


Tyr Ala Lys Lys Arg Pro Val Gly Asp Pro Phe Asp Val Lys Thr Glu 
            340                 345                 350         


Gln Gly Pro Gln Ile Asp Gln Lys Gln Phe Asp Lys Ile Leu Glu Leu 
        355                 360                 365             


Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu Glu Cys Gly Gly Ser 
    370                 375                 380                 


Ala Met Glu Asp Lys Gly Leu Phe Ile Lys Pro Thr Val Phe Ser Glu 
385                 390                 395                 400 


Val Thr Asp Asn Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
                405                 410                 415     


Gln Pro Ile Leu Lys Phe Lys Ser Ile Glu Glu Val Ile Lys Arg Ala 
            420                 425                 430         


Asn Ser Thr Asp Tyr Gly Leu Thr Ala Ala Val Phe Thr Lys Asn Leu 
        435                 440                 445             


Asp Lys Ala Leu Lys Leu Ala Ser Ala Leu Glu Ser Gly Thr Val Trp 
    450                 455                 460                 


Ile Asn Cys Tyr Asn Ala Leu Tyr Ala Gln Ala Pro Phe Gly Gly Phe 
465                 470                 475                 480 


Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu Tyr Ala Leu Ala Glu 
                485                 490                 495     


Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Leu Gly Asp Lys Asn Pro 
            500                 505                 510         


<210>  5
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Thr Thr Asn Gly Ala Val Glu Asn Gly Gln Pro Asp Gly Lys 
1               5                   10                  15      


Pro Pro Ala Leu Pro Arg Pro Ile Arg Asn Leu Glu Val Lys Phe Thr 
            20                  25                  30          


Lys Ile Phe Ile Asn Asn Asp Trp His Glu Ser Lys Ser Gly Arg Lys 
        35                  40                  45              


Phe Ala Thr Tyr Asn Pro Ser Thr Leu Glu Lys Ile Cys Glu Val Glu 
    50                  55                  60                  


Glu Gly Asp Lys Pro Asp Val Asp Lys Ala Val Glu Ala Ala Gln Ala 
65                  70                  75                  80  


Ala Phe Gln Arg Gly Ser Pro Trp Arg Arg Leu Asp Ala Leu Ser Arg 
                85                  90                  95      


Gly Gln Leu Leu His Gln Leu Ala Asp Leu Val Glu Arg Asp Arg Ala 
            100                 105                 110         


Ile Leu Ala Thr Leu Glu Thr Met Asp Thr Gly Lys Pro Phe Leu His 
        115                 120                 125             


Ala Phe Phe Val Asp Leu Glu Gly Cys Ile Lys Thr Phe Arg Tyr Phe 
    130                 135                 140                 


Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr Ile Pro Thr Asp Asp 
145                 150                 155                 160 


Asn Val Val Cys Phe Thr Arg His Glu Pro Ile Gly Val Cys Gly Ala 
                165                 170                 175     


Ile Thr Pro Trp Asn Phe Pro Leu Leu Met Leu Ala Trp Lys Leu Ala 
            180                 185                 190         


Pro Ala Leu Cys Cys Gly Asn Thr Val Val Leu Lys Pro Ala Glu Gln 
        195                 200                 205             


Thr Pro Leu Thr Ala Leu Tyr Leu Ala Ser Leu Ile Lys Glu Val Gly 
    210                 215                 220                 


Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly Phe Gly Pro Thr Val 
225                 230                 235                 240 


Gly Ala Ala Ile Ser Ser His Pro Gln Ile Asn Lys Ile Ala Phe Thr 
                245                 250                 255     


Gly Ser Thr Glu Val Gly Lys Leu Val Arg Glu Ala Ala Ser Arg Ser 
            260                 265                 270         


Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Asn Pro Cys Ile 
        275                 280                 285             


Val Cys Ala Asp Ala Asp Leu Asp Leu Ala Val Glu Cys Ala His Gln 
    290                 295                 300                 


Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Ala Ser Arg Val 
305                 310                 315                 320 


Phe Val Glu Glu Gln Val Tyr Gly Glu Phe Val Arg Arg Ser Val Glu 
                325                 330                 335     


Phe Ala Lys Lys Arg Pro Val Gly Asp Pro Phe Asp Ala Lys Thr Glu 
            340                 345                 350         


Gln Gly Pro Gln Ile Asp Gln Lys Gln Phe Asp Lys Ile Leu Glu Leu 
        355                 360                 365             


Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu Glu Cys Gly Gly Ser 
    370                 375                 380                 


Ala Met Glu Asp Arg Gly Leu Phe Ile Lys Pro Thr Val Phe Ser Asp 
385                 390                 395                 400 


Val Thr Asp Asn Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
                405                 410                 415     


Gln Pro Ile Leu Lys Phe Lys Asn Leu Glu Glu Val Ile Lys Arg Ala 
            420                 425                 430         


Asn Ser Thr Asp Tyr Gly Leu Thr Ala Ala Val Phe Thr Lys Asn Leu 
        435                 440                 445             


Asp Lys Ala Leu Lys Leu Ala Ala Ala Leu Glu Ser Gly Thr Val Trp 
    450                 455                 460                 


Ile Asn Cys Tyr Asn Ala Phe Tyr Ala Gln Ala Pro Phe Gly Gly Phe 
465                 470                 475                 480 


Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu Tyr Ala Leu Ala Glu 
                485                 490                 495     


Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Leu Glu Glu Lys Asn Pro 
            500                 505                 510         


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  6
cggctaccac atccaaggaa                                                   20


<210>  7
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  7
gctggaatta ccgcggct                                                     18


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  8
gcacgccaga cttacctgtc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  9
ccactcactg aatcatgcca                                                   20


<210>  10
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  10
gaaaccatcc ccattgact                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  11
gtctgctcag ctaccttcat c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  12
atcaactgct acaacgccct                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  13
tattcggcca aagcgtattc                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  14
cgctcaactc tttcccattt g                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  15
ttccccaatc cacctttgac                                                   20


