                         SEQUENCE LISTING

<110>  The Queen's University of Belfast
       Waugh, David J J
       Wilson, Richard
       Oladipo, Olabode
 
<120>  Predictor of response to treatment with Epidermal Growth Factor Receptor Therapeutic

<130>  P118284.WO.01

<150>  GB1106870.7
<151>  2011-04-26

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2502
<212>  DNA
<213>  Homo sapiens

<400>  1
tattcatcaa gtgccctcta gctgttaagt cactctgatc tctgactgca gctcctactg       60

ttggacacac ctggccggtg cttcagttag atcaaaccat tgctgaaact gaagaggaca      120

tgtcaaatat tacagatcca cagatgtggg attttgatga tctaaatttc actggcatgc      180

cacctgcaga tgaagattac agcccctgta tgctagaaac tgagacactc aacaagtatg      240

ttgtgatcat cgcctatgcc ctagtgttcc tgctgagcct gctgggaaac tccctggtga      300

tgctggtcat cttatacagc agggtcggcc gctccgtcac tgatgtctac ctgctgaacc      360

tggccttggc cgacctactc tttgccctga ccttgcccat ctgggccgcc tccaaggtga      420

atggctggat ttttggcaca ttcctgtgca aggtggtctc actcctgaag gaagtcaact      480

tctacagtgg catcctgctg ttggcctgca tcagtgtgga ccgttacctg gccattgtcc      540

atgccacacg cacactgacc cagaagcgtc acttggtcaa gtttgtttgt cttggctgct      600

ggggactgtc tatgaatctg tccctgccct tcttcctttt ccgccaggct taccatccaa      660

acaattccag tccagtttgc tatgaggtcc tgggaaatga cacagcaaaa tggcggatgg      720

tgttgcggat cctgcctcac acctttggct tcatcgtgcc gctgtttgtc atgctgttct      780

gctatggatt caccctgcgt acactgttta aggcccacat ggggcagaag caccgagcca      840

tgagggtcat ctttgctgtc gtcctcatct tcctgctttg ctggctgccc tacaacctgg      900

tcctgctggc agacaccctc atgaggaccc aggtgatcca ggagagctgt gagcgccgca      960

acaacatcgg ccgggccctg gatgccactg agattctggg atttctccat agctgcctca     1020

accccatcat ctacgccttc atcggccaaa attttcgcca tggattcctc aagatcctgg     1080

ctatgcatgg cctggtcagc aaggagttct tggcacgtca tcgtgttacc tcctacactt     1140

cttcgtctgt caatgtctct tccaacctct gaaaaccatc gatgaaggaa tatctcttct     1200

cagaaggaaa gaataaccaa caccctgagg ttgtgtgtgg aaggtgatct ggctctggac     1260

aggcactatc tgggttttgg ggggacgcta taggatgtgg ggaagttagg aactggtgtc     1320

ttcaggggcc acaccaacct tctgaggagc tgttgaggta cctccaagga ccggcctttg     1380

cacctccatg gaaacgaagc accatcattc ccgttgaacg tcacatcttt aacccactaa     1440

ctggctaatt agcatggcca catctgagcc ccgaatctga cattagatga gagaacaggg     1500

ctgaagctgt gtcctcatga gggctggatg ctctcgttga ccctcacagg agcatctcct     1560

caactctgag tgttaagcgt tgagccacca agctggtggc tctgtgtgct ctgatccgag     1620

ctcagggggg tggttttccc atctcaggtg tgttgcagtg tctgctggag acattgaggc     1680

aggcactgcc aaaacatcaa cctgccagct ggccttgtga ggagctggaa acacatgttc     1740

cccttggggg tggtggatga acaaagagaa agagggtttg gaagccagat ctatgccaca     1800

agaaccccct ttacccccat gaccaacatc gcagacacat gtgctggcca cctgctgagc     1860

cccaagtgga acgagacaag cagcccttag cccttcccct ctgcagcttc caggctggcg     1920

tgcagcatca gcatccctag aaagccatgt gcagccacca gtccattggg caggcagatg     1980

ttcctaataa agcttctgtt ccgtgcttgt ccctgtggaa gtatcttggt tgtgacagag     2040

tcaagggtgt gtgcagcatt gttggctgtt cctgcagtag aatgggggca gcacctccta     2100

agaaggcacc tctctgggtt gaagggcagt gttccctggg gctttaactc ctgctagaac     2160

agtctcttga ggcacagaaa ctcctgttca tgcccatacc cctggccaag gaagatccct     2220

ttgtccacaa gtaaaaggaa atgctcctcc agggagtctc agcttcaccc tgaggtgagc     2280

atcatcttct gggttaggcc ttgcctaggc atagccctgc ctcaagctat gtgagctcac     2340

cagtccctcc ccaaatgctt tccatgagtt gcagtttttt cctagtctgt tttccctcct     2400

tggagacagg gccctgtcgg tttattcact gtatgtcctt ggtgcctgga gcctactaaa     2460

tgctcaataa ataatgatca caggaaaaaa aaaaaaaaaa aa                        2502


<210>  2
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


