               SEQUENCE LISTING

<110> Sanofi 

<120> Test systems and methods for identifying and characterising lipid
      lowering drugs

<130> DE 2012/021

<160> 19

<170> PatentIn version 3.5

<210> 1
<211> 693
<212> PRT
<213> Hamster


<400> 1
Met Met Tyr Leu Ser Pro Met Gly Thr Ser Cys Ser Val Arg Pro Leu 
1               5                   10                   15    
Trp Leu Leu Thr Pro Leu Leu Leu Leu Leu Leu Leu Cys His Met Gly 
            20                   25                  30        
Ala Arg Ala Gln Asp Glu Asp Ala Glu Tyr Glu Glu Leu Met Leu Ala 
        35                   40                  45            
Leu Arg Ser Gln Glu Asp Gly Leu Ala Glu Glu Glu Ala Pro His Val 
    50                   55                  60                
Ala Thr Ala Pro Phe His Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro 
65                   70                  75                  80
Gly Thr Tyr Ile Val Val Leu Ile Asp Gly Ala Gln Arg Leu Gln Ile 
                85                   90                  95    
Glu Gln Thr Ile His Arg Leu Gln Thr Gln Ala Ala Arg Arg Gly Tyr 
            100                  105                110        
Val Ile Lys Val Leu Asp Ile Phe Tyr Asp Ile Leu Pro Gly Phe Val 
        115                  120                125            
Val Lys Met Ser Ser Asp Leu Leu Asp Leu Ala Leu Lys Leu Pro His 
    130                  135                140                
Val Lys Tyr Ile Glu Glu Asp Ser Leu Val Phe Gly Gln Ser Ile Pro 
145                  150                155                  160
Trp Asn Leu Asp Arg Ile Ile Pro Ala Gly Arg Gln Ala Gln Glu Tyr 
                165                  170                175    
Ser Ser Ser Asn Gly Ser Gly Gln Val Glu Val Tyr Leu Leu Asp Thr 
            180                  185                190        
Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr 
        195                  200                205            
Asp Phe Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln 
    210                  215                220                
Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser 
225                  230                235                  240
Gly Arg Asp Ala Gly Val Ala Lys Gly Thr Ile Leu His Ser Leu Arg 
                245                  250                255    
Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly 
            260                  265                270        
Leu Glu Phe Ile Trp Lys Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu 
        275                  280                285            
Val Val Leu Leu Pro Leu Ala Gly Arg Tyr Ser Arg Ile Leu Asn Thr 
    290                  295                300                
Ala Cys Gln His Leu Ala Ser Asn Gly Val Val Leu Val Ala Ala Ala 
305                  310                315                  320
Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro 
                325                  330                335    
Glu Val Ile Thr Val Gly Ala Thr Asp Val Gln Asp Gln Pro Val Thr 
            340                  345                350        
Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala 
        355                  360                365            
Pro Gly Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe 
    370                  375                380                
Met Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile 
385                  390                395                  400
Val Val Thr Met Leu Thr Leu Glu Pro Glu Leu Thr Leu Ala Glu Leu 
                405                  410                415    
Arg Gln Arg Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala 
            420                  425                430        
Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Thr 
        435                  440                445            
Met Pro Pro Lys Thr His Gly Thr Gly Gly Gln Leu Leu Cys Arg Thr 
    450                  455                460                
Val Trp Ser Ala His Ser Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala 
465                  470                475                  480
Arg Cys Ala Pro Gly Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg 
                485                  490                495    
Ser Gly Arg Arg Arg Gly Asp Arg Ile Glu Ala Ile Gly Gly Gln Gln 
            500                  505                510        
Val Cys Lys Ala Phe Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Val 
        515                  520                525            
Ala Arg Cys Cys Leu Leu Pro Arg Ala Asn Cys Ser Thr His Thr Thr 
    530                  535                540                
Pro Ala Ala Arg Thr Ser Leu Gly Thr His Val His Cys His Gln Lys 
545                  550                555                  560
Asp His Val Leu Thr Gly Cys Ser Phe His Trp Glu Val Glu Gly Ile 
                565                  570                575    
Gly Val Gln Arg Trp Ala Val Leu Arg Ser Arg His Gln Pro Gly Gln 
            580                  585                590        
Cys Ile Gly His Arg Glu Ala Ser Ala His Ala Ser Cys Cys His Ala 
        595                  600                605            
Pro Gly Leu Asp Cys Lys Ile Lys Glu His Gly Ile Ser Gly Pro Ala 
    610                  615                620                
Glu Gln Val Thr Val Ala Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys 
625                  630                635                  640
Asn Val Leu Pro Gly Ala Phe Met Thr Leu Gly Ala Tyr Ala Val Asp 
                645                  650                655    
Asn Met Cys Val Ala Arg Ser Cys Ala Thr Asp Thr Ala Gly Arg Thr 
            660                  665                670        
Ser Glu Glu Ala Ile Val Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro 
        675                  680                685            
Ser Ala Lys Ala Ser 
    690            

<210> 2
<211> 692
<212> PRT
<213> Homo sapiens


<400> 2
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                   15    
Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                   25                  30        
Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                   40                  45            
Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                   55                  60                
His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                   70                  75                  80
Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                   90                  95    
Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                  105                110        
His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                  120                125            
Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                  135                140                
Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                  150                155                  160
Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                  170                175    
Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                  185                190        
His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                  200                205            
Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                  215                220                
Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                  230                235                  240
Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                  250                255    
Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                  265                270        
Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                  280                285            
Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                  295                300                
Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                  310                315                  320
Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                  330                335    
Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                  345                350        
Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                  360                365            
Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                  375                380                
Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                  390                395                  400
Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                  410                415    
His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                  425                430        
Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                  440                445            
His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                  455                460                
Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                  470                475                  480
Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                  490                495    
Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                  505                510        
Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                  520                525            
Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                  535                540                
Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                  550                555                  560
Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                  570                575    
Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                  585                590        
Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                  600                605            
Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                  615                620                
Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                  630                635                  640
Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                  650                655    
Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                  665                670        
Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                  680                685            
Gln Glu Leu Gln 
    690        

<210> 3
<211> 8
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 3
Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5            

<210> 4
<211> 8
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 4
Ile Ser Gly Ser Gly Gly Thr Thr 
1               5            

<210> 5
<211> 11
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 5
Ala Lys Asp Ser Asn Trp Gly Asn Phe Asp Leu 
1               5                   10    

<210> 6
<211> 12
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 6
Gln Ser Val Leu Tyr Arg Ser Asn Asn Arg Asn Phe 
1               5                   10        

<210> 7
<211> 3
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 7
Trp Ala Ser 
1               

<210> 8
<211> 9
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 8
Gln Gln Tyr Tyr Thr Thr Pro Tyr Thr 
1               5                

<210> 9
<211> 118
<212> PRT
<213> Artificial sequences

<220>
<223> Antibody sequence

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                   25                  30        
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                   40                  45            
Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Ile Ile Ser Arg Asp Ser Ser Lys His Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Lys Asp Ser Asn Trp Gly Asn Phe Asp Leu Trp Gly Arg Gly Thr 
            100                  105                110        
Leu Val Thr Val Ser Ser 
        115            

<210> 10
<211> 113
<212> PRT
<213> Artificial sequences

<220> 
<222> 1..113
<223> Antibody sequence

<400> 10
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                   15    
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 
            20                   25                  30        
Ser Asn Asn Arg Asn Phe Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                   40                  45            
Pro Pro Asn Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                   55                  60                
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                   70                  75                  80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                   90                  95    
Tyr Tyr Thr Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                  105                110        
Lys 
    

<210> 11
<211> 2082
<212> DNA
<213> Hamster


<400> 11
atgatgtacc tctccccgat gggtaccagc tgctctgtga ggccgctgtg gcttctgacg      60

ccactgctgc tgttgctgtt actgtgccac atgggcgccc gtgcccagga tgaggacgcc     120

gagtacgaag agctgatgct agctctcagg tcccaggagg atggcttggc cgaagaggag     180

gccccgcatg tggccaccgc ccccttccac cgttgctcca aggaggcctg gaggctgcca     240

ggcacctaca tagtagtgct gatagatggg gcccagcggc tgcagattga acaaaccatc     300

catcgcctgc agacccaagc tgcccgccga ggctatgtca tcaaggttct ggatatcttc     360

tacgacatct tgcctggctt cgtggtgaag atgagcagtg acctattgga cctggccctg     420

aagttgcccc acgtgaagta catcgaggaa gactcccttg tcttcggcca gagcatcccc     480

tggaacctgg atcggattat cccagcaggg cgccaggcac aggaatacag ctcctccaat     540

ggaagtggcc aggtagaggt gtatctctta gataccagca tccagagtga ccatcgggaa     600

attgagggca gggtcaccat cactgacttc aacagtgtgc ctgaggagga tgggacacgc     660

ttccacaggc aggcaagcaa gtgtgacagc catggcaccc atctggcagg cgtggtcagc     720

ggccgggatg ctggtgtggc caagggcacc atcctgcaca gtctgcgtgt gctcaactgt     780

caagggaaag gcacggtcag cggcaccctc ataggcctgg agttcatttg gaaaagccag     840

ctaatccagc cttcagggcc actagtggtg ctgctgcccc tggcgggcag gtatagccgg     900

atcctcaaca ctgcctgcca gcacctggca agcaatggag tggtgttggt tgctgcagct     960

ggcaacttcc gggatgatgc ctgcctctac tccccagctt ctgctccaga ggtcatcaca    1020

gttggggcca ccgatgtcca ggaccagcca gtcaccctgg ggactttggg gaccaacttt    1080

ggacgctgtg tggacctctt tgctcctggg aaagacatca ttggtgcctc cagtgactgt    1140

agcacatgct tcatgtcaca gagtgggaca tcgcaggccg ctgctcatgt ggctggcatt    1200

gtagtcacga tgctgactct ggagccggag ctcaccttgg ctgagctgcg gcagaggctg    1260

atccacttct ctaccaaaga tgtcatcaac atggcctggt tccctgagga ccagcgggtg    1320

ctgaccccca acctggtggc cacaatgccc cccaaaactc atgggacagg tgggcagctg    1380

ctctgcagga cagtgtggtc ggcacactcg gggcccacaa ggacagctac tgctacagcc    1440

cgctgcgccc caggagagga gctgctgagt tgttccagct tctccaggag tgggaggcga    1500

aggggtgatc ggattgaggc catagggggg cagcaggtct gcaaggcctt caatgcattt    1560

gggggtgaag gtgtctacgc tgtcgctagg tgctgcctgc ttcctcgtgc caactgtagc    1620

acccacacca ctcctgcagc cagaactagc ctggggaccc atgtccactg ccaccagaag    1680

gaccatgtcc tgacaggctg cagctttcac tgggaggtgg aaggcattgg tgtccaacgg    1740

tgggctgtgc tgaggtccag acatcagcct ggtcaatgca ttggccaccg ggaggccagc    1800

gcccatgctt cctgctgcca tgccccaggc ctggattgca aaatcaagga gcatgggatc    1860

tcaggtcctg cagagcaggt caccgtggcc tgtgaggcag gctggaccct gactggatgc    1920

aacgtcctcc ctggggcatt catgactctg ggggcctacg ccgtggacaa catgtgtgtg    1980

gcaagaagct gtgccactga cacagcaggc aggaccagtg aggaagccat agtagctgct    2040

gccatctgct gccggagccg gccttcagca aaggcctcct ag                       2082


<210> 12
<211> 8
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 12
Gly Phe Thr Phe Ser Ser His Trp 
1               5            

<210> 13
<211> 8
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 13
Ile Asn Gln Asp Gly Ser Glu Lys 
1               5            

<210> 14
<211> 20
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 14
Ala Arg Asp Ile Val Leu Met Val Tyr Asp Met Asp Tyr Tyr Tyr Tyr 
1               5                   10                   15    
Gly Met Asp Val 
            20

<210> 15
<211> 11
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 15
Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr 
1               5                   10    

<210> 16
<211> 3
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 16
Leu Gly Ser  
1               

<210> 17
<211> 9
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 17
Met Gln Thr Leu Gln Thr Pro Leu Thr 
1               5                

<210> 18
<211> 127
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 18
Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                   25                  30        
Trp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Asp Ile Val Leu Met Val Tyr Asp Met Asp Tyr Tyr Tyr Tyr 
            100                  105                110        
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                  120                125        

<210> 19
<211> 112
<212> PRT
<213> Artificial sequences

<220> 
<223> Antibody sequence

<400> 19
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                   15    
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                   25                  30        
Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                   40                  45            
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                   55                  60                
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                   70                  75                  80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                   90                  95    
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                  105                110        

