                         SEQUENCE LISTING

<110>  LYSANDO Holding AG
 
<120>  New Antimicrobial Agents

<130>  LYS-009 PCT

<140>  unknown
<141>  2012-04-27

<150>  EP 11163897.9
<151>  2011-04-27

<160>  105   

<170>  PatentIn version 3.3

<210>  1
<211>  486
<212>  PRT
<213>  unknown

<220>
<223>  Ply2638 A endolysin

<400>  1

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys 
                485     


<210>  2
<211>  1458
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A endolysin

<400>  2
atgctgaccg caattgatta cctgaccaaa aaaggctgga aaatctcttc cgatccgcgt     60

acctatgatg gctatccgaa aaactacggc taccgcaact accacgagaa cggtatcaac    120

tatgatgaat tttgcggcgg ctatcaccgt gcctttgatg tttactccaa cgaaacgaac    180

gatgtgccag cagttactag cggtactgtt atcgaggcga acgattacgg taacttcggc    240

ggtactttcg ttatccgcga cgcgaacgac aacgattgga tctatggcca cctgcagcgc    300

ggttccatgc gttttgttgt tggcgacaaa gtgaaccagg gcgacattat tggtctgcag    360

ggtaacagca actattacga caacccgatg agcgttcacc tgcatctgca gctgcgtccg    420

aaagacgcca aaaaagacga aaaaagccag gtttgctctg gtctggcgat ggagaaatac    480

gatatcacca acctgaacgc gaaacaggac aaaagcaaaa acggctctgt caaagaactg    540

aaacacatct actctaacca cattaaaggt aacaaaatca ccgctccgaa accgtctatt    600

cagggtgtcg tgatccacaa cgattacggt tccatgactc caagccagta cctcccgtgg    660

ctgtacgctc gtgaaaacaa cggtactcac gttaacggct gggcatctgt atacgccaac    720

cgcaacgaag tactgtggta ccacccgact gattatgttg aatggcattg cggtaaccag    780

tgggcaaacg cgaacctgat tggtttcgaa gtctgtgaat cttacccggg tcgtatttct    840

gacaaactgt tcctggagaa cgaagaggct actctcaaag tggctgcaga cgtgatgaaa    900

agctacggtc tgccagtaaa ccgtaacacc gttcgcctgc ataacgaatt tttcggcacc    960

tcctgtccgc accgttcttg ggatctgcac gttggtaaag gcgaaccgta caccactacg   1020

aacatcaaca aaatgaaaga ctacttcatc aaacgtatca aacactacta tgatggcggc   1080

aaactggaag tatctaaagc tgcgacgatc aaacagtccg acgtcaaaca ggaggtaaaa   1140

aaacaggagg cgaaacagat tgttaaagcc accgactgga aacagaacaa agacggcatc   1200

tggtacaaag ctgaacacgc ttctttcacc gtgactgcac cagagggcat tatcacgcgt   1260

tataaaggtc cgtggaccgg tcatccacag gctggtgtgc tgcagaaagg tcagacgatc   1320

aaatatgacg aggttcagaa attcgacggt catgtatggg tatcttggga aacgtttgaa   1380

ggtgaaacgg tctatatgcc ggtgcgcact tgggatgcga aaaccggtaa agtgggcaaa   1440

ctgtggggtg aaatcaaa                                                 1458


<210>  3
<211>  68
<212>  PRT
<213>  unknown

<220>
<223>  peptidoglycan binding domain of Ply2638A endolysin

<400>  3

Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile 
1               5                   10                  15      


Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val 
            20                  25                  30          


Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp 
        35                  40                  45              


Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr 
    50                  55                  60                  


Met Pro Val Arg 
65              


<210>  4
<211>  100
<212>  PRT
<213>  unknown

<220>
<223>  M23 peptidase domain of Ply2638A endolysin

<400>  4

Tyr His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro 
1               5                   10                  15      


Ala Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe 
            20                  25                  30          


Gly Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr 
        35                  40                  45              


Gly His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val 
    50                  55                  60                  


Asn Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp 
65                  70                  75                  80  


Asn Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala 
                85                  90                  95      


Lys Lys Asp Glu 
            100 


<210>  5
<211>  127
<212>  PRT
<213>  unknown

<220>
<223>  putative amidase domain of Ply2638A endolysin

<400>  5

Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro Ser 
1               5                   10                  15      


Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His Val 
            20                  25                  30          


Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp Tyr 
        35                  40                  45              


His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala Asn 
    50                  55                  60                  


Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg Ile 
65                  70                  75                  80  


Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val Ala 
                85                  90                  95      


Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr Val 
            100                 105                 110         


Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser 
        115                 120                 125         


<210>  6
<211>  485
<212>  PRT
<213>  unknown

<220>
<223>  Ply2638A endolysin without Met

<400>  6

Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser 
1               5                   10                  15      


Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn 
            20                  25                  30          


Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His 
        35                  40                  45              


Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val 
    50                  55                  60                  


Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly 
65                  70                  75                  80  


Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His 
                85                  90                  95      


Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn Gln 
            100                 105                 110         


Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro 
        115                 120                 125             


Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys 
    130                 135                 140                 


Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp 
145                 150                 155                 160 


Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val 
                165                 170                 175     


Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile 
            180                 185                 190         


Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr 
        195                 200                 205             


Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu 
    210                 215                 220                 


Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg 
225                 230                 235                 240 


Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys 
                245                 250                 255     


Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu 
            260                 265                 270         


Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu 
        275                 280                 285             


Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro 
    290                 295                 300                 


Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser 
305                 310                 315                 320 


Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr 
                325                 330                 335     


Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile 
            340                 345                 350         


Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr 
        355                 360                 365             


Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys 
    370                 375                 380                 


Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp 
385                 390                 395                 400 


Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile 
                405                 410                 415     


Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val 
            420                 425                 430         


Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp 
        435                 440                 445             


Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr 
    450                 455                 460                 


Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu 
465                 470                 475                 480 


Trp Gly Glu Ile Lys 
                485 


<210>  7
<211>  497
<212>  PRT
<213>  unknown

<220>
<223>  PK-Ply2638A

<400>  7

Ala Met Gly Lys Arg Lys Lys Arg Lys Lys Arg Lys Leu Thr Ala Ile 
1               5                   10                  15      


Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr 
            20                  25                  30          


Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn 
        35                  40                  45              


Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp 
    50                  55                  60                  


Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr 
65                  70                  75                  80  


Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile 
                85                  90                  95      


Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly 
            100                 105                 110         


Ser Met Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile 
        115                 120                 125             


Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His 
    130                 135                 140                 


Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser 
145                 150                 155                 160 


Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu 
                165                 170                 175     


Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys 
            180                 185                 190         


His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys 
        195                 200                 205             


Pro Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr 
    210                 215                 220                 


Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr 
225                 230                 235                 240 


His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu 
                245                 250                 255     


Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp 
            260                 265                 270         


Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly 
        275                 280                 285             


Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys 
    290                 295                 300                 


Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn 
305                 310                 315                 320 


Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg 
                325                 330                 335     


Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn 
            340                 345                 350         


Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr 
        355                 360                 365             


Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser 
    370                 375                 380                 


Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys 
385                 390                 395                 400 


Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu 
                405                 410                 415     


His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr 
            420                 425                 430         


Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly 
        435                 440                 445             


Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp 
    450                 455                 460                 


Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg 
465                 470                 475                 480 


Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile 
                485                 490                 495     


Lys 
    


<210>  8
<211>  1491
<212>  DNA
<213>  unknown

<220>
<223>  PK-Ply2638A

<400>  8
gccatgggca agcgtaagaa acgcaaaaaa cgcaaactga ccgcaattga ttacctgacc     60

aaaaaaggct ggaaaatctc ttccgatccg cgtacctatg atggctatcc gaaaaactac    120

ggctaccgca actaccacga gaacggtatc aactatgatg aattttgcgg cggctatcac    180

cgtgcctttg atgtttactc caacgaaacg aacgatgtgc cagcagttac tagcggtact    240

gttatcgagg cgaacgatta cggtaacttc ggcggtactt tcgttatccg cgacgcgaac    300

gacaacgatt ggatctatgg ccacctgcag cgcggttcca tgcgttttgt tgttggcgac    360

aaagtgaacc agggcgacat tattggtctg cagggtaaca gcaactatta cgacaacccg    420

atgagcgttc acctgcatct gcagctgcgt ccgaaagacg ccaaaaaaga cgaaaaaagc    480

caggtttgct ctggtctggc gatggagaaa tacgatatca ccaacctgaa cgcgaaacag    540

gacaaaagca aaaacggctc tgtcaaagaa ctgaaacaca tctactctaa ccacattaaa    600

ggtaacaaaa tcaccgctcc gaaaccgtct attcagggtg tcgtgatcca caacgattac    660

ggttccatga ctccaagcca gtacctcccg tggctgtacg ctcgtgaaaa caacggtact    720

cacgttaacg gctgggcatc tgtatacgcc aaccgcaacg aagtactgtg gtaccacccg    780

actgattatg ttgaatggca ttgcggtaac cagtgggcaa acgcgaacct gattggtttc    840

gaagtctgtg aatcttaccc gggtcgtatt tctgacaaac tgttcctgga gaacgaagag    900

gctactctca aagtggctgc agacgtgatg aaaagctacg gtctgccagt aaaccgtaac    960

accgttcgcc tgcataacga atttttcggc acctcctgtc cgcaccgttc ttgggatctg   1020

cacgttggta aaggcgaacc gtacaccact acgaacatca acaaaatgaa agactacttc   1080

atcaaacgta tcaaacacta ctatgatggc ggcaaactgg aagtatctaa agctgcgacg   1140

atcaaacagt ccgacgtcaa acaggaggta aaaaaacagg aggcgaaaca gattgttaaa   1200

gccaccgact ggaaacagaa caaagacggc atctggtaca aagctgaaca cgcttctttc   1260

accgtgactg caccagaggg cattatcacg cgttataaag gtccgtggac cggtcatcca   1320

caggctggtg tgctgcagaa aggtcagacg atcaaatatg acgaggttca gaaattcgac   1380

ggtcatgtat gggtatcttg ggaaacgttt gaaggtgaaa cggtctatat gccggtgcgc   1440

acttgggatg cgaaaaccgg taaagtgggc aaactgtggg gtgaaatcaa a            1491


<210>  9
<211>  500
<212>  PRT
<213>  unknown

<220>
<223>  Ply2638A-PK

<400>  9

Ala Met Gly Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys 
1               5                   10                  15      


Ile Ser Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly 
            20                  25                  30          


Tyr Arg Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly 
        35                  40                  45              


Gly Tyr His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val 
    50                  55                  60                  


Pro Ala Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn 
65                  70                  75                  80  


Phe Gly Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile 
                85                  90                  95      


Tyr Gly His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys 
            100                 105                 110         


Val Asn Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr 
        115                 120                 125             


Asp Asn Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp 
    130                 135                 140                 


Ala Lys Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu 
145                 150                 155                 160 


Lys Tyr Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn 
                165                 170                 175     


Gly Ser Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly 
            180                 185                 190         


Asn Lys Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His 
        195                 200                 205             


Asn Asp Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr 
    210                 215                 220                 


Ala Arg Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr 
225                 230                 235                 240 


Ala Asn Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu 
                245                 250                 255     


Trp His Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu 
            260                 265                 270         


Val Cys Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu 
        275                 280                 285             


Asn Glu Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr 
    290                 295                 300                 


Gly Leu Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe 
305                 310                 315                 320 


Gly Thr Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly 
                325                 330                 335     


Glu Pro Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile 
            340                 345                 350         


Lys Arg Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys 
        355                 360                 365             


Ala Ala Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln 
    370                 375                 380                 


Glu Ala Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp 
385                 390                 395                 400 


Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro 
                405                 410                 415     


Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln 
            420                 425                 430         


Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln 
        435                 440                 445             


Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu 
    450                 455                 460                 


Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val 
465                 470                 475                 480 


Gly Lys Leu Trp Gly Glu Ile Lys Gly Ser Gly Lys Arg Lys Lys Arg 
                485                 490                 495     


Lys Lys Arg Lys 
            500 


<210>  10
<211>  1500
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A-PK

<400>  10
gccatgggcc tgaccgcaat tgattacctg accaaaaaag gctggaaaat ctcttccgat     60

ccgcgtacct atgatggcta tccgaaaaac tacggctacc gcaactacca cgagaacggt    120

atcaactatg atgaattttg cggcggctat caccgtgcct ttgatgttta ctccaacgaa    180

acgaacgatg tgccagcagt tactagcggt actgttatcg aggcgaacga ttacggtaac    240

ttcggcggta ctttcgttat ccgcgacgcg aacgacaacg attggatcta tggccacctg    300

cagcgcggtt ccatgcgttt tgttgttggc gacaaagtga accagggcga cattattggt    360

ctgcagggta acagcaacta ttacgacaac ccgatgagcg ttcacctgca tctgcagctg    420

cgtccgaaag acgccaaaaa agacgaaaaa agccaggttt gctctggtct ggcgatggag    480

aaatacgata tcaccaacct gaacgcgaaa caggacaaaa gcaaaaacgg ctctgtcaaa    540

gaactgaaac acatctactc taaccacatt aaaggtaaca aaatcaccgc tccgaaaccg    600

tctattcagg gtgtcgtgat ccacaacgat tacggttcca tgactccaag ccagtacctc    660

ccgtggctgt acgctcgtga aaacaacggt actcacgtta acggctgggc atctgtatac    720

gccaaccgca acgaagtact gtggtaccac ccgactgatt atgttgaatg gcattgcggt    780

aaccagtggg caaacgcgaa cctgattggt ttcgaagtct gtgaatctta cccgggtcgt    840

atttctgaca aactgttcct ggagaacgaa gaggctactc tcaaagtggc tgcagacgtg    900

atgaaaagct acggtctgcc agtaaaccgt aacaccgttc gcctgcataa cgaatttttc    960

ggcacctcct gtccgcaccg ttcttgggat ctgcacgttg gtaaaggcga accgtacacc   1020

actacgaaca tcaacaaaat gaaagactac ttcatcaaac gtatcaaaca ctactatgat   1080

ggcggcaaac tggaagtatc taaagctgcg acgatcaaac agtccgacgt caaacaggag   1140

gtaaaaaaac aggaggcgaa acagattgtt aaagccaccg actggaaaca gaacaaagac   1200

ggcatctggt acaaagctga acacgcttct ttcaccgtga ctgcaccaga gggcattatc   1260

acgcgttata aaggtccgtg gaccggtcat ccacaggctg gtgtgctgca gaaaggtcag   1320

acgatcaaat atgacgaggt tcagaaattc gacggtcatg tatgggtatc ttgggaaacg   1380

tttgaaggtg aaacggtcta tatgccggtg cgcacttggg atgcgaaaac cggtaaagtg   1440

ggcaaactgt ggggtgaaat caaagggtcg ggaaagcgta agaaacgcaa aaaacgcaaa   1500


<210>  11
<211>  6
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  11

Lys Arg Lys Lys Arg Lys 
1               5       


<210>  12
<211>  9
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  12

Lys Arg Lys Lys Arg Lys Lys Arg Lys 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  13

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  14

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  15

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10  


<210>  16
<211>  12
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  16

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys 
1               5                   10          


<210>  17
<211>  14
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  17

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg 
1               5                   10                  


<210>  18
<211>  16
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  18

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


<210>  19
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  19

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys 
            


<210>  20
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  20

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg 
            


<210>  21
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  21

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  22
<211>  20
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  22

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys 
            20  


<210>  23
<211>  21
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  23

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Lys 
            20      


<210>  24
<211>  21
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  24

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys 
            20      


<210>  25
<211>  22
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  25

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Lys Arg Lys 
1               5                   10                  15      


Lys Arg Lys Lys Arg Lys 
            20          


<210>  26
<211>  24
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  26

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Ser Gly Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys 
            20                  


<210>  27
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  27

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Lys 
            20                  25  


<210>  28
<211>  31
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  28

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys 
            20                  25                  30      


<210>  29
<211>  38
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  29

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Ser Gly Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Gly Ser Gly Ser Gly Lys Arg Lys 
            20                  25                  30          


Lys Arg Lys Lys Arg Lys 
        35              


<210>  30
<211>  39
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  30

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg 
            20                  25                  30          


Lys Lys Arg Lys Lys Arg Lys 
        35                  


<210>  31
<211>  42
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  31

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys 
        35                  40          


<210>  32
<211>  5
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  wherein Xaa is any other amino acid residue than lysine, arginine
       and histidine

<400>  32

Lys Arg Xaa Lys Arg 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  33

Lys Arg Ser Lys Arg 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  unknown

<220>
<223>  synthetic peptide

<400>  34

Lys Arg Gly Ser Gly 
1               5   


<210>  35
<211>  36
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A forward primer

<400>  35
catgccatgg gcctgaccgc aattgattac ctgacc                               36


<210>  36
<211>  40
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A reverse primer

<400>  36
ccgctcgagt catcatttga tttcacccca cagtttgccc                           40


<210>  37
<211>  63
<212>  DNA
<213>  unknown

<220>
<223>  PK-Ply2638A forward primer

<400>  37
catgccatgg gcaagcgtaa gaaacgcaaa aaacgcaaac tgaccgcaat tgattacctg     60

acc                                                                   63


<210>  38
<211>  40
<212>  DNA
<213>  unknown

<220>
<223>  PK-Ply2638A reverse primer

<400>  38
ccgctcgagt catcatttga tttcacccca cagtttgccc                           40


<210>  39
<211>  36
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A-PK forward primer

<400>  39
catgccatgg gcctgaccgc aattgattac ctgacc                               36


<210>  40
<211>  74
<212>  DNA
<213>  unknown

<220>
<223>  Ply2638A-PK reverse primer

<400>  40
ccgctcgagt catcatttgc gttttttgcg tttcttacgc tttcccgacc ctttgatttc     60

accccacagt ttgc                                                       74


<210>  41
<211>  24
<212>  PRT
<213>  unknown

<220>
<223>  Pseudin 1

<400>  41

Gly Leu Asn Thr Leu Lys Lys Val Phe Gln Gly Leu His Glu Ala Ile 
1               5                   10                  15      


Lys Leu Ile Asn Asn His Val Gln 
            20                  


<210>  42
<211>  37
<212>  PRT
<213>  unknown

<220>
<223>  LL-37

<400>  42

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  43
<211>  13
<212>  PRT
<213>  unknown

<220>
<223>  Indolicidin

<400>  43

Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  44
<211>  23
<212>  PRT
<213>  unknown

<220>
<223>  Magainin

<400>  44

Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  45
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Pleurocidin

<400>  45

Gly Trp Gly Ser Phe Phe Lys Lys Ala Ala His Val Gly Lys His Val 
1               5                   10                  15      


Gly Lys Ala Ala Leu Thr His Tyr Leu 
            20                  25  


<210>  46
<211>  36
<212>  PRT
<213>  unknown

<220>
<223>  Cecropin A (A.aegypti)

<400>  46

Gly Gly Leu Lys Lys Leu Gly Lys Lys Leu Glu Gly Ala Gly Lys Arg 
1               5                   10                  15      


Val Phe Asn Ala Ala Glu Lys Ala Leu Pro Val Val Ala Gly Ala Lys 
            20                  25                  30          


Ala Leu Arg Lys 
        35      


<210>  47
<211>  21
<212>  PRT
<213>  unknown

<220>
<223>  Buforin II

<400>  47

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  48
<211>  39
<212>  PRT
<213>  unknown

<220>
<223>  Sarcotoxin IA

<400>  48

Gly Trp Leu Lys Lys Ile Gly Lys Lys Ile Glu Arg Val Gly Gln His 
1               5                   10                  15      


Thr Arg Asp Ala Thr Ile Gln Gly Leu Gly Ile Ala Gln Gln Ala Ala 
            20                  25                  30          


Asn Val Ala Ala Thr Ala Arg 
        35                  


<210>  49
<211>  29
<212>  PRT
<213>  unknown

<220>
<223>  SMAP-29

<400>  49

Arg Gly Leu Arg Arg Leu Gly Arg Lys Ile Ala His Gly Val Lys Lys 
1               5                   10                  15      


Tyr Gly Pro Thr Val Leu Arg Ile Ile Arg Ile Ala Gly 
            20                  25                  


<210>  50
<211>  54
<212>  PRT
<213>  unknown

<220>
<223>  OR-7

<400>  50

Lys Thr Tyr Tyr Gly Thr Asn Gly Val His Cys Thr Lys Asn Ser Leu 
1               5                   10                  15      


Trp Gly Lys Val Arg Leu Lys Asn Met Lys Tyr Asp Gln Asn Thr Thr 
            20                  25                  30          


Tyr Met Gly Arg Leu Gln Asp Ile Leu Leu Gly Trp Ala Thr Gly Ala 
        35                  40                  45              


Phe Gly Lys Thr Phe His 
    50                  


<210>  51
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  Protegrin

<400>  51

Arg Gly Gly Arg Leu Cys Tyr Cys Arg Arg Arg Phe Cys Val Cys Val 
1               5                   10                  15      


Gly Arg 
        


<210>  52
<211>  31
<212>  PRT
<213>  unknown

<220>
<223>  Cecropin P1

<400>  52

Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210>  53
<211>  40
<212>  PRT
<213>  unknown

<220>
<223>  Cecropin A (D. melanogaster)

<400>  53

Gly Trp Leu Lys Lys Ile Gly Lys Lys Ile Glu Arg Val Gly Gln His 
1               5                   10                  15      


Thr Arg Asp Ala Thr Ile Gln Gly Leu Gly Ile Pro Gln Gln Ala Ala 
            20                  25                  30          


Asn Val Ala Ala Thr Ala Arg Gly 
        35                  40  


<210>  54
<211>  24
<212>  PRT
<213>  unknown

<220>
<223>  Ascaphine

<400>  54

Gly Ile Lys Asp Trp Ile Lys Gly Ala Ala Lys Lys Leu Ile Lys Thr 
1               5                   10                  15      


Val Ala Ser His Ile Ala Asn Gln 
            20                  


<210>  55
<211>  17
<212>  PRT
<213>  unknown

<220>
<223>  Apidaecine

<400>  55

Ala Asn Arg Pro Val Tyr Ile Pro Pro Pro Arg Pro Pro His Pro Arg 
1               5                   10                  15      


Leu 
    


<210>  56
<211>  22
<212>  PRT
<213>  unknown

<220>
<223>  Nigrocine

<400>  56

Gly Leu Leu Ser Lys Val Leu Gly Val Gly Lys Lys Val Leu Cys Gly 
1               5                   10                  15      


Val Ser Gly Leu Val Cys 
            20          


<210>  57
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  Parasin 1

<400>  57

Lys Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Ala Lys Ala Lys Thr 
1               5                   10                  15      


Arg Ser Ser 
            


<210>  58
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Lycotoxin

<400>  58

Ile Trp Leu Thr Ala Leu Lys Phe Leu Gly Lys His Ala Ala Lys Lys 
1               5                   10                  15      


Leu Ala Lys Gln Gln Leu Ser Lys Leu 
            20                  25  


<210>  59
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  Ranalexin

<400>  59

Phe Leu Gly Gly Leu Ile Val Pro Ala Met Ile Cys Ala Val Thr Lys 
1               5                   10                  15      


Lys Cys 
        


<210>  60
<211>  26
<212>  PRT
<213>  unknown

<220>
<223>  Melittin

<400>  60

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  61
<211>  38
<212>  PRT
<213>  unknown

<220>
<223>  Buforin I

<400>  61

Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Ala Lys Ala Lys Thr Arg 
1               5                   10                  15      


Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His Arg Leu 
            20                  25                  30          


Leu Arg Lys Gly Asn Tyr 
        35              


<210>  62
<211>  13
<212>  PRT
<213>  unknown

<220>
<223>  Alpha 4

<400>  62

Pro Asn Arg Ala Lys Arg Val Ile Thr Thr Phe Arg Thr 
1               5                   10              


<210>  63
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  Artilysin1

<400>  63

Gly Phe Phe Ile Pro Ala Val Ile Leu Pro Ser Ile Ala Phe Leu Ile 
1               5                   10                  15      


Val Pro 
        


<210>  64
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Artilysin2

<400>  64

Gly Lys Pro Gly Trp Leu Ile Lys Lys Ala Leu Val Phe Lys Lys Leu 
1               5                   10                  15      


Ile Arg Arg Pro Leu Lys Arg Leu Ala 
            20                  25  


<210>  65
<211>  27
<212>  PRT
<213>  unknown

<220>
<223>  WLBU2 variant

<400>  65

Lys Arg Trp Val Lys Arg Val Lys Arg Val Lys Arg Trp Val Lys Arg 
1               5                   10                  15      


Val Val Arg Val Val Lys Arg Trp Val Lys Arg 
            20                  25          


<210>  66
<211>  526
<212>  PRT
<213>  artificial

<220>
<223>  LL-37-Ply2638A

<400>  66

Met Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys 
1               5                   10                  15      


Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu 
            20                  25                  30          


Val Pro Arg Thr Glu Ser Gly Ser Met Leu Thr Ala Ile Asp Tyr Leu 
        35                  40                  45              


Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr Asp Gly 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly Ile Asn 
65                  70                  75                  80  


Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val Tyr Ser 
                85                  90                  95      


Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val Ile Glu 
            100                 105                 110         


Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg Asp Ala 
        115                 120                 125             


Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser Met Arg 
    130                 135                 140                 


Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly Leu Gln 
145                 150                 155                 160 


Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu His Leu 
                165                 170                 175     


Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln Val Cys 
            180                 185                 190         


Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn Ala Lys 
        195                 200                 205             


Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His Ile Tyr 
    210                 215                 220                 


Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro Ser Ile 
225                 230                 235                 240 


Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro Ser Gln 
                245                 250                 255     


Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His Val Asn 
            260                 265                 270         


Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp Tyr His 
        275                 280                 285             


Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala Asn Ala 
    290                 295                 300                 


Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg Ile Ser 
305                 310                 315                 320 


Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val Ala Ala 
                325                 330                 335     


Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr Val Arg 
            340                 345                 350         


Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser Trp Asp 
        355                 360                 365             


Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile Asn Lys 
    370                 375                 380                 


Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp Gly Gly 
385                 390                 395                 400 


Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp Val Lys 
                405                 410                 415     


Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala Thr Asp 
            420                 425                 430         


Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser 
        435                 440                 445             


Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro 
    450                 455                 460                 


Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile 
465                 470                 475                 480 


Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp 
                485                 490                 495     


Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp 
            500                 505                 510         


Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
        515                 520                 525     


<210>  67
<211>  1581
<212>  DNA
<213>  artificial

<220>
<223>  LL-37-Ply2638A

<400>  67
atgctcctgg gtgacttctt tcgcaaatcc aaagagaaaa tcggcaaaga gttcaaacgt     60

atcgtgcagc gcattaaaga ctttctgcgt aacctggttc cgcgtaccga atctggatcc    120

atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc    180

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    240

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    300

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    360

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    420

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    480

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    540

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    600

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    660

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    720

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    780

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    840

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    900

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    960

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag   1020

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact   1080

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1140

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1200

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1260

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1320

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1380

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1440

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1500

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1560

ttgtggggcg aaattaaatg a                                             1581


<210>  68
<211>  518
<212>  PRT
<213>  artificial

<220>
<223>  SMAP-29-Ply2638A

<400>  68

Met Arg Gly Leu Arg Arg Leu Gly Arg Lys Ile Ala His Gly Val Lys 
1               5                   10                  15      


Lys Tyr Gly Pro Thr Val Leu Arg Ile Ile Arg Ile Ala Gly Gly Ser 
            20                  25                  30          


Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
        35                  40                  45              


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
    50                  55                  60                  


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
65                  70                  75                  80  


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
                85                  90                  95      


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
            100                 105                 110         


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
        115                 120                 125             


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
    130                 135                 140                 


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
145                 150                 155                 160 


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
                165                 170                 175     


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
            180                 185                 190         


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
        195                 200                 205             


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
    210                 215                 220                 


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
225                 230                 235                 240 


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
                245                 250                 255     


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
            260                 265                 270         


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
        275                 280                 285             


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
    290                 295                 300                 


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
305                 310                 315                 320 


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
                325                 330                 335     


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
            340                 345                 350         


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
        355                 360                 365             


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
    370                 375                 380                 


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
385                 390                 395                 400 


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
                405                 410                 415     


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
            420                 425                 430         


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
        435                 440                 445             


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
    450                 455                 460                 


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
465                 470                 475                 480 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
                485                 490                 495     


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
            500                 505                 510         


Leu Trp Gly Glu Ile Lys 
        515             


<210>  69
<211>  1557
<212>  DNA
<213>  artificial

<220>
<223>  SMAP-29-Ply2638A

<400>  69
atgcgtggtc tgcgtcgcct gggtcgcaaa attgcgcacg gcgtcaaaaa atacggcccg     60

accgtgctgc gcattatccg catcgctggt ggatccatgc taactgctat tgactatctt    120

acgaaaaaag gttggaaaat atcatctgac cctcgcactt acgatggtta ccctaaaaac    180

tacggctaca gaaattacca tgaaaacggc attaattatg atgagttttg tggtggttat    240

catagagctt ttgatgttta cagtaacgaa actaacgacg tgcctgctgt tactagcgga    300

acagttattg aagcaaacga ttacggtaat tttggtggta cattcgttat tagagacgct    360

aacgataacg attggatata tgggcatcta caacgtggct caatgcgatt tgttgtaggc    420

gacaaagtca atcaaggtga cattattggt ttacaaggta atagcaacta ttacgacaat    480

cctatgagtg tacatttaca tttacaatta cgccctaaag acgcaaagaa agatgaaaaa    540

tcacaagtat gtagtggttt ggctatggaa aaatatgaca ttacaaattt aaatgctaaa    600

caagataaat caaagaatgg gagcgtgaaa gagttgaaac atatctattc aaaccatatt    660

aaaggtaaca agattacagc accaaaacct agtattcaag gtgtggtcat ccacaatgat    720

tatggtagta tgacacctag tcaatactta ccatggttat atgcacgtga gaataacggt    780

acacacgtta acggttgggc tagtgtttat gcaaatagaa acgaagtgct ttggtatcat    840

ccgacagact acgtagagtg gcattgtggt aatcaatggg caaatgctaa cttaatcgga    900

tttgaagtgt gtgagtcgta tcctggtaga atctcggaca aattattctt agaaaatgaa    960

gaagcgacat tgaaagtagc tgcggatgtg atgaagtcgt acggattacc agttaatcgc   1020

aacactgtac gtctgcataa cgaattcttc ggaacttctt gtccacatcg ttcgtgggac   1080

ttgcatgttg gcaaaggtga gccttacaca actactaata ttaataaaat gaaagactac   1140

ttcatcaaac gcatcaaaca ttattatgac ggtggaaagc tagaagtaag caaagcagca   1200

actatcaaac aatctgacgt taagcaagaa gttaaaaagc aagaagcaaa acaaattgtg   1260

aaagcaacag attggaaaca gaataaagat ggcatttggt ataaagctga acatgcttcg   1320

ttcacagtga cagcaccaga gggaattatc acaagataca aaggtccttg gactggtcac   1380

ccacaagctg gtgtattaca aaaaggtcaa acgattaaat atgatgaggt tcaaaaattt   1440

gacggtcatg tttgggtatc gtgggaaacg tttgagggcg aaactgtata catgccggta   1500

cgcacatggg acgctaaaac tggtaaagtt ggtaagttgt ggggcgaaat taaatga      1557


<210>  70
<211>  525
<212>  PRT
<213>  artificial

<220>
<223>  Cecropin A (A.aegypti)-Ply2638A

<400>  70

Met Gly Gly Leu Lys Lys Leu Gly Lys Lys Leu Glu Gly Ala Gly Lys 
1               5                   10                  15      


Arg Val Phe Asn Ala Ala Glu Lys Ala Leu Pro Val Val Ala Gly Ala 
            20                  25                  30          


Lys Ala Leu Arg Lys Gly Ser Met Leu Thr Ala Ile Asp Tyr Leu Thr 
        35                  40                  45              


Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr Asp Gly Tyr 
    50                  55                  60                  


Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly Ile Asn Tyr 
65                  70                  75                  80  


Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val Tyr Ser Asn 
                85                  90                  95      


Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val Ile Glu Ala 
            100                 105                 110         


Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg Asp Ala Asn 
        115                 120                 125             


Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser Met Arg Phe 
    130                 135                 140                 


Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly Leu Gln Gly 
145                 150                 155                 160 


Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu His Leu Gln 
                165                 170                 175     


Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln Val Cys Ser 
            180                 185                 190         


Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn Ala Lys Gln 
        195                 200                 205             


Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His Ile Tyr Ser 
    210                 215                 220                 


Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro Ser Ile Gln 
225                 230                 235                 240 


Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro Ser Gln Tyr 
                245                 250                 255     


Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His Val Asn Gly 
            260                 265                 270         


Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp Tyr His Pro 
        275                 280                 285             


Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala Asn Ala Asn 
    290                 295                 300                 


Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg Ile Ser Asp 
305                 310                 315                 320 


Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val Ala Ala Asp 
                325                 330                 335     


Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr Val Arg Leu 
            340                 345                 350         


His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser Trp Asp Leu 
        355                 360                 365             


His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile Asn Lys Met 
    370                 375                 380                 


Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp Gly Gly Lys 
385                 390                 395                 400 


Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp Val Lys Gln 
                405                 410                 415     


Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala Thr Asp Trp 
            420                 425                 430         


Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe 
        435                 440                 445             


Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp 
    450                 455                 460                 


Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys 
465                 470                 475                 480 


Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu 
                485                 490                 495     


Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala 
            500                 505                 510         


Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
        515                 520                 525 


<210>  71
<211>  1578
<212>  DNA
<213>  artificial

<220>
<223>  Cecropin A (A.aegypti)-Ply2638A

<400>  71
atgggcggcc tgaaaaaact gggcaaaaaa ctggaaggtg ccggcaaacg tgtgttcaac     60

gctgcagaaa aagcactgcc ggttgtagct ggtgctaaag ctctccgtaa aggatccatg    120

ctaactgcta ttgactatct tacgaaaaaa ggttggaaaa tatcatctga ccctcgcact    180

tacgatggtt accctaaaaa ctacggctac agaaattacc atgaaaacgg cattaattat    240

gatgagtttt gtggtggtta tcatagagct tttgatgttt acagtaacga aactaacgac    300

gtgcctgctg ttactagcgg aacagttatt gaagcaaacg attacggtaa ttttggtggt    360

acattcgtta ttagagacgc taacgataac gattggatat atgggcatct acaacgtggc    420

tcaatgcgat ttgttgtagg cgacaaagtc aatcaaggtg acattattgg tttacaaggt    480

aatagcaact attacgacaa tcctatgagt gtacatttac atttacaatt acgccctaaa    540

gacgcaaaga aagatgaaaa atcacaagta tgtagtggtt tggctatgga aaaatatgac    600

attacaaatt taaatgctaa acaagataaa tcaaagaatg ggagcgtgaa agagttgaaa    660

catatctatt caaaccatat taaaggtaac aagattacag caccaaaacc tagtattcaa    720

ggtgtggtca tccacaatga ttatggtagt atgacaccta gtcaatactt accatggtta    780

tatgcacgtg agaataacgg tacacacgtt aacggttggg ctagtgttta tgcaaataga    840

aacgaagtgc tttggtatca tccgacagac tacgtagagt ggcattgtgg taatcaatgg    900

gcaaatgcta acttaatcgg atttgaagtg tgtgagtcgt atcctggtag aatctcggac    960

aaattattct tagaaaatga agaagcgaca ttgaaagtag ctgcggatgt gatgaagtcg   1020

tacggattac cagttaatcg caacactgta cgtctgcata acgaattctt cggaacttct   1080

tgtccacatc gttcgtggga cttgcatgtt ggcaaaggtg agccttacac aactactaat   1140

attaataaaa tgaaagacta cttcatcaaa cgcatcaaac attattatga cggtggaaag   1200

ctagaagtaa gcaaagcagc aactatcaaa caatctgacg ttaagcaaga agttaaaaag   1260

caagaagcaa aacaaattgt gaaagcaaca gattggaaac agaataaaga tggcatttgg   1320

tataaagctg aacatgcttc gttcacagtg acagcaccag agggaattat cacaagatac   1380

aaaggtcctt ggactggtca cccacaagct ggtgtattac aaaaaggtca aacgattaaa   1440

tatgatgagg ttcaaaaatt tgacggtcat gtttgggtat cgtgggaaac gtttgagggc   1500

gaaactgtat acatgccggt acgcacatgg gacgctaaaa ctggtaaagt tggtaagttg   1560

tggggcgaaa ttaaatga                                                 1578


<210>  72
<211>  528
<212>  PRT
<213>  artificial

<220>
<223>  Sarcotoxin IA-Ply2638A

<400>  72

Met Gly Trp Leu Lys Lys Ile Gly Lys Lys Ile Glu Arg Val Gly Gln 
1               5                   10                  15      


His Thr Arg Asp Ala Thr Ile Gln Gly Leu Gly Ile Ala Gln Gln Ala 
            20                  25                  30          


Ala Asn Val Ala Ala Thr Ala Arg Gly Ser Met Leu Thr Ala Ile Asp 
        35                  40                  45              


Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr 
    50                  55                  60                  


Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly 
65                  70                  75                  80  


Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val 
                85                  90                  95      


Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val 
            100                 105                 110         


Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg 
        115                 120                 125             


Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser 
    130                 135                 140                 


Met Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly 
145                 150                 155                 160 


Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu 
                165                 170                 175     


His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln 
            180                 185                 190         


Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn 
        195                 200                 205             


Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His 
    210                 215                 220                 


Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro 
225                 230                 235                 240 


Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro 
                245                 250                 255     


Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His 
            260                 265                 270         


Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp 
        275                 280                 285             


Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala 
    290                 295                 300                 


Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg 
305                 310                 315                 320 


Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val 
                325                 330                 335     


Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr 
            340                 345                 350         


Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser 
        355                 360                 365             


Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile 
    370                 375                 380                 


Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp 
385                 390                 395                 400 


Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp 
                405                 410                 415     


Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala 
            420                 425                 430         


Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His 
        435                 440                 445             


Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys 
    450                 455                 460                 


Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln 
465                 470                 475                 480 


Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val 
                485                 490                 495     


Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr 
            500                 505                 510         


Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
        515                 520                 525             


<210>  73
<211>  1587
<212>  DNA
<213>  artificial

<220>
<223>  Sarcotoxin IA-Ply2638A

<400>  73
atgggatggc tcaaaaagat tggcaagaaa atcgagcgag tcggtcagca tacgcgtgat     60

gcaactatcc agggtttagg tatcgcacag caagcagcta atgtagcagc tactgctcgg    120

ggatccatgc taactgctat tgactatctt acgaaaaaag gttggaaaat atcatctgac    180

cctcgcactt acgatggtta ccctaaaaac tacggctaca gaaattacca tgaaaacggc    240

attaattatg atgagttttg tggtggttat catagagctt ttgatgttta cagtaacgaa    300

actaacgacg tgcctgctgt tactagcgga acagttattg aagcaaacga ttacggtaat    360

tttggtggta cattcgttat tagagacgct aacgataacg attggatata tgggcatcta    420

caacgtggct caatgcgatt tgttgtaggc gacaaagtca atcaaggtga cattattggt    480

ttacaaggta atagcaacta ttacgacaat cctatgagtg tacatttaca tttacaatta    540

cgccctaaag acgcaaagaa agatgaaaaa tcacaagtat gtagtggttt ggctatggaa    600

aaatatgaca ttacaaattt aaatgctaaa caagataaat caaagaatgg gagcgtgaaa    660

gagttgaaac atatctattc aaaccatatt aaaggtaaca agattacagc accaaaacct    720

agtattcaag gtgtggtcat ccacaatgat tatggtagta tgacacctag tcaatactta    780

ccatggttat atgcacgtga gaataacggt acacacgtta acggttgggc tagtgtttat    840

gcaaatagaa acgaagtgct ttggtatcat ccgacagact acgtagagtg gcattgtggt    900

aatcaatggg caaatgctaa cttaatcgga tttgaagtgt gtgagtcgta tcctggtaga    960

atctcggaca aattattctt agaaaatgaa gaagcgacat tgaaagtagc tgcggatgtg   1020

atgaagtcgt acggattacc agttaatcgc aacactgtac gtctgcataa cgaattcttc   1080

ggaacttctt gtccacatcg ttcgtgggac ttgcatgttg gcaaaggtga gccttacaca   1140

actactaata ttaataaaat gaaagactac ttcatcaaac gcatcaaaca ttattatgac   1200

ggtggaaagc tagaagtaag caaagcagca actatcaaac aatctgacgt taagcaagaa   1260

gttaaaaagc aagaagcaaa acaaattgtg aaagcaacag attggaaaca gaataaagat   1320

ggcatttggt ataaagctga acatgcttcg ttcacagtga cagcaccaga gggaattatc   1380

acaagataca aaggtccttg gactggtcac ccacaagctg gtgtattaca aaaaggtcaa   1440

acgattaaat atgatgaggt tcaaaaattt gacggtcatg tttgggtatc gtgggaaacg   1500

tttgagggcg aaactgtata catgccggta cgcacatggg acgctaaaac tggtaaagtt   1560

ggtaagttgt ggggcgaaat taaatga                                       1587


<210>  74
<211>  543
<212>  PRT
<213>  artificial

<220>
<223>  OR-7-Ply2638A

<400>  74

Met Lys Thr Tyr Tyr Gly Thr Asn Gly Val His Cys Thr Lys Asn Ser 
1               5                   10                  15      


Leu Trp Gly Lys Val Arg Leu Lys Asn Met Lys Tyr Asp Gln Asn Thr 
            20                  25                  30          


Thr Tyr Met Gly Arg Leu Gln Asp Ile Leu Leu Gly Trp Ala Thr Gly 
        35                  40                  45              


Ala Phe Gly Lys Thr Phe His Gly Ser Met Leu Thr Ala Ile Asp Tyr 
    50                  55                  60                  


Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr Asp 
65                  70                  75                  80  


Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly Ile 
                85                  90                  95      


Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val Tyr 
            100                 105                 110         


Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val Ile 
        115                 120                 125             


Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg Asp 
    130                 135                 140                 


Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser Met 
145                 150                 155                 160 


Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly Leu 
                165                 170                 175     


Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu His 
            180                 185                 190         


Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln Val 
        195                 200                 205             


Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn Ala 
    210                 215                 220                 


Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His Ile 
225                 230                 235                 240 


Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro Ser 
                245                 250                 255     


Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro Ser 
            260                 265                 270         


Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His Val 
        275                 280                 285             


Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp Tyr 
    290                 295                 300                 


His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala Asn 
305                 310                 315                 320 


Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg Ile 
                325                 330                 335     


Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val Ala 
            340                 345                 350         


Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr Val 
        355                 360                 365             


Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser Trp 
    370                 375                 380                 


Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile Asn 
385                 390                 395                 400 


Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp Gly 
                405                 410                 415     


Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp Val 
            420                 425                 430         


Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala Thr 
        435                 440                 445             


Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala 
    450                 455                 460                 


Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly 
465                 470                 475                 480 


Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr 
                485                 490                 495     


Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser 
            500                 505                 510         


Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp 
        515                 520                 525             


Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
    530                 535                 540             


<210>  75
<211>  1632
<212>  DNA
<213>  artificial

<220>
<223>  OR-7-Ply2638A

<400>  75
atgaaaacct actatggcac caacggcgta cactgcacca aaaacagcct gtggggtaaa     60

gtgcgtctga aaaacatgaa atacgaccag aacaccacgt atatgggccg tctccaggat    120

atcctgctgg gttgggcaac tggtgccttc ggcaaaacct ttcacggatc catgctaact    180

gctattgact atcttacgaa aaaaggttgg aaaatatcat ctgaccctcg cacttacgat    240

ggttacccta aaaactacgg ctacagaaat taccatgaaa acggcattaa ttatgatgag    300

ttttgtggtg gttatcatag agcttttgat gtttacagta acgaaactaa cgacgtgcct    360

gctgttacta gcggaacagt tattgaagca aacgattacg gtaattttgg tggtacattc    420

gttattagag acgctaacga taacgattgg atatatgggc atctacaacg tggctcaatg    480

cgatttgttg taggcgacaa agtcaatcaa ggtgacatta ttggtttaca aggtaatagc    540

aactattacg acaatcctat gagtgtacat ttacatttac aattacgccc taaagacgca    600

aagaaagatg aaaaatcaca agtatgtagt ggtttggcta tggaaaaata tgacattaca    660

aatttaaatg ctaaacaaga taaatcaaag aatgggagcg tgaaagagtt gaaacatatc    720

tattcaaacc atattaaagg taacaagatt acagcaccaa aacctagtat tcaaggtgtg    780

gtcatccaca atgattatgg tagtatgaca cctagtcaat acttaccatg gttatatgca    840

cgtgagaata acggtacaca cgttaacggt tgggctagtg tttatgcaaa tagaaacgaa    900

gtgctttggt atcatccgac agactacgta gagtggcatt gtggtaatca atgggcaaat    960

gctaacttaa tcggatttga agtgtgtgag tcgtatcctg gtagaatctc ggacaaatta   1020

ttcttagaaa atgaagaagc gacattgaaa gtagctgcgg atgtgatgaa gtcgtacgga   1080

ttaccagtta atcgcaacac tgtacgtctg cataacgaat tcttcggaac ttcttgtcca   1140

catcgttcgt gggacttgca tgttggcaaa ggtgagcctt acacaactac taatattaat   1200

aaaatgaaag actacttcat caaacgcatc aaacattatt atgacggtgg aaagctagaa   1260

gtaagcaaag cagcaactat caaacaatct gacgttaagc aagaagttaa aaagcaagaa   1320

gcaaaacaaa ttgtgaaagc aacagattgg aaacagaata aagatggcat ttggtataaa   1380

gctgaacatg cttcgttcac agtgacagca ccagagggaa ttatcacaag atacaaaggt   1440

ccttggactg gtcacccaca agctggtgta ttacaaaaag gtcaaacgat taaatatgat   1500

gaggttcaaa aatttgacgg tcatgtttgg gtatcgtggg aaacgtttga gggcgaaact   1560

gtatacatgc cggtacgcac atgggacgct aaaactggta aagttggtaa gttgtggggc   1620

gaaattaaat ga                                                       1632


<210>  76
<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  Indolicidin-Ply2638A

<400>  76

Met Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg Gly Ser 
1               5                   10                  15      


Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
            20                  25                  30          


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
        35                  40                  45              


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
    50                  55                  60                  


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
65                  70                  75                  80  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
                85                  90                  95      


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
            100                 105                 110         


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
        115                 120                 125             


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
    130                 135                 140                 


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
145                 150                 155                 160 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
                165                 170                 175     


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
            180                 185                 190         


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
        195                 200                 205             


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
    210                 215                 220                 


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
225                 230                 235                 240 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
                245                 250                 255     


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
            260                 265                 270         


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
        275                 280                 285             


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
    290                 295                 300                 


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
305                 310                 315                 320 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
                325                 330                 335     


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
            340                 345                 350         


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
        355                 360                 365             


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
    370                 375                 380                 


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
385                 390                 395                 400 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
                405                 410                 415     


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
            420                 425                 430         


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
        435                 440                 445             


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
    450                 455                 460                 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
465                 470                 475                 480 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
                485                 490                 495     


Leu Trp Gly Glu Ile Lys 
            500         


<210>  77
<211>  1509
<212>  DNA
<213>  artificial

<220>
<223>  Indolicidin-Ply2638A

<400>  77
atgatcctgc cgtggaaatg gccgtggtgg ccatggcgtc gcggatccat gctaactgct     60

attgactatc ttacgaaaaa aggttggaaa atatcatctg accctcgcac ttacgatggt    120

taccctaaaa actacggcta cagaaattac catgaaaacg gcattaatta tgatgagttt    180

tgtggtggtt atcatagagc ttttgatgtt tacagtaacg aaactaacga cgtgcctgct    240

gttactagcg gaacagttat tgaagcaaac gattacggta attttggtgg tacattcgtt    300

attagagacg ctaacgataa cgattggata tatgggcatc tacaacgtgg ctcaatgcga    360

tttgttgtag gcgacaaagt caatcaaggt gacattattg gtttacaagg taatagcaac    420

tattacgaca atcctatgag tgtacattta catttacaat tacgccctaa agacgcaaag    480

aaagatgaaa aatcacaagt atgtagtggt ttggctatgg aaaaatatga cattacaaat    540

ttaaatgcta aacaagataa atcaaagaat gggagcgtga aagagttgaa acatatctat    600

tcaaaccata ttaaaggtaa caagattaca gcaccaaaac ctagtattca aggtgtggtc    660

atccacaatg attatggtag tatgacacct agtcaatact taccatggtt atatgcacgt    720

gagaataacg gtacacacgt taacggttgg gctagtgttt atgcaaatag aaacgaagtg    780

ctttggtatc atccgacaga ctacgtagag tggcattgtg gtaatcaatg ggcaaatgct    840

aacttaatcg gatttgaagt gtgtgagtcg tatcctggta gaatctcgga caaattattc    900

ttagaaaatg aagaagcgac attgaaagta gctgcggatg tgatgaagtc gtacggatta    960

ccagttaatc gcaacactgt acgtctgcat aacgaattct tcggaacttc ttgtccacat   1020

cgttcgtggg acttgcatgt tggcaaaggt gagccttaca caactactaa tattaataaa   1080

atgaaagact acttcatcaa acgcatcaaa cattattatg acggtggaaa gctagaagta   1140

agcaaagcag caactatcaa acaatctgac gttaagcaag aagttaaaaa gcaagaagca   1200

aaacaaattg tgaaagcaac agattggaaa cagaataaag atggcatttg gtataaagct   1260

gaacatgctt cgttcacagt gacagcacca gagggaatta tcacaagata caaaggtcct   1320

tggactggtc acccacaagc tggtgtatta caaaaaggtc aaacgattaa atatgatgag   1380

gttcaaaaat ttgacggtca tgtttgggta tcgtgggaaa cgtttgaggg cgaaactgta   1440

tacatgccgg tacgcacatg ggacgctaaa actggtaaag ttggtaagtt gtggggcgaa   1500

attaaatga                                                           1509


<210>  78
<211>  513
<212>  PRT
<213>  artificial

<220>
<223>  Pseudin1-Ply2638A

<400>  78

Met Gly Leu Asn Thr Leu Lys Lys Val Phe Gln Gly Leu His Glu Ala 
1               5                   10                  15      


Ile Lys Leu Ile Asn Asn His Val Gln Gly Ser Met Leu Thr Ala Ile 
            20                  25                  30          


Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr 
        35                  40                  45              


Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn 
    50                  55                  60                  


Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp 
65                  70                  75                  80  


Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr 
                85                  90                  95      


Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile 
            100                 105                 110         


Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly 
        115                 120                 125             


Ser Met Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile 
    130                 135                 140                 


Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His 
145                 150                 155                 160 


Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser 
                165                 170                 175     


Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu 
            180                 185                 190         


Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys 
        195                 200                 205             


His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys 
    210                 215                 220                 


Pro Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr 
225                 230                 235                 240 


Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr 
                245                 250                 255     


His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu 
            260                 265                 270         


Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp 
        275                 280                 285             


Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly 
    290                 295                 300                 


Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys 
305                 310                 315                 320 


Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn 
                325                 330                 335     


Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg 
            340                 345                 350         


Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn 
        355                 360                 365             


Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr 
    370                 375                 380                 


Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser 
385                 390                 395                 400 


Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys 
                405                 410                 415     


Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu 
            420                 425                 430         


His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr 
        435                 440                 445             


Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly 
    450                 455                 460                 


Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp 
465                 470                 475                 480 


Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg 
                485                 490                 495     


Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile 
            500                 505                 510         


Lys 
    


<210>  79
<211>  1542
<212>  DNA
<213>  artificial

<220>
<223>  Pseudin1-Ply2638A

<400>  79
atgggtctga acaccctgaa aaaagtattc cagggtctgc atgaagcgat taaactgatc     60

aacaaccacg ttcagggatc catgctaact gctattgact atcttacgaa aaaaggttgg    120

aaaatatcat ctgaccctcg cacttacgat ggttacccta aaaactacgg ctacagaaat    180

taccatgaaa acggcattaa ttatgatgag ttttgtggtg gttatcatag agcttttgat    240

gtttacagta acgaaactaa cgacgtgcct gctgttacta gcggaacagt tattgaagca    300

aacgattacg gtaattttgg tggtacattc gttattagag acgctaacga taacgattgg    360

atatatgggc atctacaacg tggctcaatg cgatttgttg taggcgacaa agtcaatcaa    420

ggtgacatta ttggtttaca aggtaatagc aactattacg acaatcctat gagtgtacat    480

ttacatttac aattacgccc taaagacgca aagaaagatg aaaaatcaca agtatgtagt    540

ggtttggcta tggaaaaata tgacattaca aatttaaatg ctaaacaaga taaatcaaag    600

aatgggagcg tgaaagagtt gaaacatatc tattcaaacc atattaaagg taacaagatt    660

acagcaccaa aacctagtat tcaaggtgtg gtcatccaca atgattatgg tagtatgaca    720

cctagtcaat acttaccatg gttatatgca cgtgagaata acggtacaca cgttaacggt    780

tgggctagtg tttatgcaaa tagaaacgaa gtgctttggt atcatccgac agactacgta    840

gagtggcatt gtggtaatca atgggcaaat gctaacttaa tcggatttga agtgtgtgag    900

tcgtatcctg gtagaatctc ggacaaatta ttcttagaaa atgaagaagc gacattgaaa    960

gtagctgcgg atgtgatgaa gtcgtacgga ttaccagtta atcgcaacac tgtacgtctg   1020

cataacgaat tcttcggaac ttcttgtcca catcgttcgt gggacttgca tgttggcaaa   1080

ggtgagcctt acacaactac taatattaat aaaatgaaag actacttcat caaacgcatc   1140

aaacattatt atgacggtgg aaagctagaa gtaagcaaag cagcaactat caaacaatct   1200

gacgttaagc aagaagttaa aaagcaagaa gcaaaacaaa ttgtgaaagc aacagattgg   1260

aaacagaata aagatggcat ttggtataaa gctgaacatg cttcgttcac agtgacagca   1320

ccagagggaa ttatcacaag atacaaaggt ccttggactg gtcacccaca agctggtgta   1380

ttacaaaaag gtcaaacgat taaatatgat gaggttcaaa aatttgacgg tcatgtttgg   1440

gtatcgtggg aaacgtttga gggcgaaact gtatacatgc cggtacgcac atgggacgct   1500

aaaactggta aagttggtaa gttgtggggc gaaattaaat ga                      1542


<210>  80
<211>  512
<212>  PRT
<213>  artificial

<220>
<223>  Magainin-Ply2638A

<400>  80

Met Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala 
1               5                   10                  15      


Phe Val Gly Glu Ile Met Asn Ser Gly Ser Met Leu Thr Ala Ile Asp 
            20                  25                  30          


Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr 
        35                  40                  45              


Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly 
    50                  55                  60                  


Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val 
65                  70                  75                  80  


Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val 
                85                  90                  95      


Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg 
            100                 105                 110         


Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser 
        115                 120                 125             


Met Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly 
    130                 135                 140                 


Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu 
145                 150                 155                 160 


His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln 
                165                 170                 175     


Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn 
            180                 185                 190         


Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His 
        195                 200                 205             


Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro 
    210                 215                 220                 


Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro 
225                 230                 235                 240 


Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His 
                245                 250                 255     


Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp 
            260                 265                 270         


Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala 
        275                 280                 285             


Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg 
    290                 295                 300                 


Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val 
305                 310                 315                 320 


Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr 
                325                 330                 335     


Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser 
            340                 345                 350         


Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile 
        355                 360                 365             


Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp 
    370                 375                 380                 


Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp 
385                 390                 395                 400 


Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala 
                405                 410                 415     


Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His 
            420                 425                 430         


Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys 
        435                 440                 445             


Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln 
    450                 455                 460                 


Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val 
465                 470                 475                 480 


Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr 
                485                 490                 495     


Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
            500                 505                 510         


<210>  81
<211>  1539
<212>  DNA
<213>  artificial

<220>
<223>  Magainin-Ply2638A

<400>  81
atgggtatcg gcaaattcct gcactccgca aaaaaattcg gcaaagcttt cgtgggcgaa     60

attatgaact ctggatccat gctaactgct attgactatc ttacgaaaaa aggttggaaa    120

atatcatctg accctcgcac ttacgatggt taccctaaaa actacggcta cagaaattac    180

catgaaaacg gcattaatta tgatgagttt tgtggtggtt atcatagagc ttttgatgtt    240

tacagtaacg aaactaacga cgtgcctgct gttactagcg gaacagttat tgaagcaaac    300

gattacggta attttggtgg tacattcgtt attagagacg ctaacgataa cgattggata    360

tatgggcatc tacaacgtgg ctcaatgcga tttgttgtag gcgacaaagt caatcaaggt    420

gacattattg gtttacaagg taatagcaac tattacgaca atcctatgag tgtacattta    480

catttacaat tacgccctaa agacgcaaag aaagatgaaa aatcacaagt atgtagtggt    540

ttggctatgg aaaaatatga cattacaaat ttaaatgcta aacaagataa atcaaagaat    600

gggagcgtga aagagttgaa acatatctat tcaaaccata ttaaaggtaa caagattaca    660

gcaccaaaac ctagtattca aggtgtggtc atccacaatg attatggtag tatgacacct    720

agtcaatact taccatggtt atatgcacgt gagaataacg gtacacacgt taacggttgg    780

gctagtgttt atgcaaatag aaacgaagtg ctttggtatc atccgacaga ctacgtagag    840

tggcattgtg gtaatcaatg ggcaaatgct aacttaatcg gatttgaagt gtgtgagtcg    900

tatcctggta gaatctcgga caaattattc ttagaaaatg aagaagcgac attgaaagta    960

gctgcggatg tgatgaagtc gtacggatta ccagttaatc gcaacactgt acgtctgcat   1020

aacgaattct tcggaacttc ttgtccacat cgttcgtggg acttgcatgt tggcaaaggt   1080

gagccttaca caactactaa tattaataaa atgaaagact acttcatcaa acgcatcaaa   1140

cattattatg acggtggaaa gctagaagta agcaaagcag caactatcaa acaatctgac   1200

gttaagcaag aagttaaaaa gcaagaagca aaacaaattg tgaaagcaac agattggaaa   1260

cagaataaag atggcatttg gtataaagct gaacatgctt cgttcacagt gacagcacca   1320

gagggaatta tcacaagata caaaggtcct tggactggtc acccacaagc tggtgtatta   1380

caaaaaggtc aaacgattaa atatgatgag gttcaaaaat ttgacggtca tgtttgggta   1440

tcgtgggaaa cgtttgaggg cgaaactgta tacatgccgg tacgcacatg ggacgctaaa   1500

actggtaaag ttggtaagtt gtggggcgaa attaaatga                          1539


<210>  82
<211>  514
<212>  PRT
<213>  artificial

<220>
<223>  Pleurocidin-Ply2638A

<400>  82

Met Gly Trp Gly Ser Phe Phe Lys Lys Ala Ala His Val Gly Lys His 
1               5                   10                  15      


Val Gly Lys Ala Ala Leu Thr His Tyr Leu Gly Ser Met Leu Thr Ala 
            20                  25                  30          


Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg 
        35                  40                  45              


Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu 
    50                  55                  60                  


Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe 
65                  70                  75                  80  


Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly 
                85                  90                  95      


Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val 
            100                 105                 110         


Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg 
        115                 120                 125             


Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile 
    130                 135                 140                 


Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val 
145                 150                 155                 160 


His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys 
                165                 170                 175     


Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn 
            180                 185                 190         


Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu 
        195                 200                 205             


Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro 
    210                 215                 220                 


Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met 
225                 230                 235                 240 


Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly 
                245                 250                 255     


Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val 
            260                 265                 270         


Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln 
        275                 280                 285             


Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro 
    290                 295                 300                 


Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu 
305                 310                 315                 320 


Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg 
                325                 330                 335     


Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His 
            340                 345                 350         


Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr 
        355                 360                 365             


Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr 
    370                 375                 380                 


Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln 
385                 390                 395                 400 


Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val 
                405                 410                 415     


Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala 
            420                 425                 430         


Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg 
        435                 440                 445             


Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys 
    450                 455                 460                 


Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val 
465                 470                 475                 480 


Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val 
                485                 490                 495     


Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu 
            500                 505                 510         


Ile Lys 
        


<210>  83
<211>  1545
<212>  DNA
<213>  artificial

<220>
<223>  Pleurocidin-Ply2638A

<400>  83
atgggctggg gttctttctt taaaaaagcg gctcacgttg gcaaacatgt aggtaaagca     60

gctctgaccc actatctggg atccatgcta actgctattg actatcttac gaaaaaaggt    120

tggaaaatat catctgaccc tcgcacttac gatggttacc ctaaaaacta cggctacaga    180

aattaccatg aaaacggcat taattatgat gagttttgtg gtggttatca tagagctttt    240

gatgtttaca gtaacgaaac taacgacgtg cctgctgtta ctagcggaac agttattgaa    300

gcaaacgatt acggtaattt tggtggtaca ttcgttatta gagacgctaa cgataacgat    360

tggatatatg ggcatctaca acgtggctca atgcgatttg ttgtaggcga caaagtcaat    420

caaggtgaca ttattggttt acaaggtaat agcaactatt acgacaatcc tatgagtgta    480

catttacatt tacaattacg ccctaaagac gcaaagaaag atgaaaaatc acaagtatgt    540

agtggtttgg ctatggaaaa atatgacatt acaaatttaa atgctaaaca agataaatca    600

aagaatggga gcgtgaaaga gttgaaacat atctattcaa accatattaa aggtaacaag    660

attacagcac caaaacctag tattcaaggt gtggtcatcc acaatgatta tggtagtatg    720

acacctagtc aatacttacc atggttatat gcacgtgaga ataacggtac acacgttaac    780

ggttgggcta gtgtttatgc aaatagaaac gaagtgcttt ggtatcatcc gacagactac    840

gtagagtggc attgtggtaa tcaatgggca aatgctaact taatcggatt tgaagtgtgt    900

gagtcgtatc ctggtagaat ctcggacaaa ttattcttag aaaatgaaga agcgacattg    960

aaagtagctg cggatgtgat gaagtcgtac ggattaccag ttaatcgcaa cactgtacgt   1020

ctgcataacg aattcttcgg aacttcttgt ccacatcgtt cgtgggactt gcatgttggc   1080

aaaggtgagc cttacacaac tactaatatt aataaaatga aagactactt catcaaacgc   1140

atcaaacatt attatgacgg tggaaagcta gaagtaagca aagcagcaac tatcaaacaa   1200

tctgacgtta agcaagaagt taaaaagcaa gaagcaaaac aaattgtgaa agcaacagat   1260

tggaaacaga ataaagatgg catttggtat aaagctgaac atgcttcgtt cacagtgaca   1320

gcaccagagg gaattatcac aagatacaaa ggtccttgga ctggtcaccc acaagctggt   1380

gtattacaaa aaggtcaaac gattaaatat gatgaggttc aaaaatttga cggtcatgtt   1440

tgggtatcgt gggaaacgtt tgagggcgaa actgtataca tgccggtacg cacatgggac   1500

gctaaaactg gtaaagttgg taagttgtgg ggcgaaatta aatga                   1545


<210>  84
<211>  510
<212>  PRT
<213>  artificial

<220>
<223>  BuforinII-Ply2638A

<400>  84

Met Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val 
1               5                   10                  15      


His Arg Leu Leu Arg Lys Gly Ser Met Leu Thr Ala Ile Asp Tyr Leu 
            20                  25                  30          


Thr Lys Lys Gly Trp Lys Ile Ser Ser Asp Pro Arg Thr Tyr Asp Gly 
        35                  40                  45              


Tyr Pro Lys Asn Tyr Gly Tyr Arg Asn Tyr His Glu Asn Gly Ile Asn 
    50                  55                  60                  


Tyr Asp Glu Phe Cys Gly Gly Tyr His Arg Ala Phe Asp Val Tyr Ser 
65                  70                  75                  80  


Asn Glu Thr Asn Asp Val Pro Ala Val Thr Ser Gly Thr Val Ile Glu 
                85                  90                  95      


Ala Asn Asp Tyr Gly Asn Phe Gly Gly Thr Phe Val Ile Arg Asp Ala 
            100                 105                 110         


Asn Asp Asn Asp Trp Ile Tyr Gly His Leu Gln Arg Gly Ser Met Arg 
        115                 120                 125             


Phe Val Val Gly Asp Lys Val Asn Gln Gly Asp Ile Ile Gly Leu Gln 
    130                 135                 140                 


Gly Asn Ser Asn Tyr Tyr Asp Asn Pro Met Ser Val His Leu His Leu 
145                 150                 155                 160 


Gln Leu Arg Pro Lys Asp Ala Lys Lys Asp Glu Lys Ser Gln Val Cys 
                165                 170                 175     


Ser Gly Leu Ala Met Glu Lys Tyr Asp Ile Thr Asn Leu Asn Ala Lys 
            180                 185                 190         


Gln Asp Lys Ser Lys Asn Gly Ser Val Lys Glu Leu Lys His Ile Tyr 
        195                 200                 205             


Ser Asn His Ile Lys Gly Asn Lys Ile Thr Ala Pro Lys Pro Ser Ile 
    210                 215                 220                 


Gln Gly Val Val Ile His Asn Asp Tyr Gly Ser Met Thr Pro Ser Gln 
225                 230                 235                 240 


Tyr Leu Pro Trp Leu Tyr Ala Arg Glu Asn Asn Gly Thr His Val Asn 
                245                 250                 255     


Gly Trp Ala Ser Val Tyr Ala Asn Arg Asn Glu Val Leu Trp Tyr His 
            260                 265                 270         


Pro Thr Asp Tyr Val Glu Trp His Cys Gly Asn Gln Trp Ala Asn Ala 
        275                 280                 285             


Asn Leu Ile Gly Phe Glu Val Cys Glu Ser Tyr Pro Gly Arg Ile Ser 
    290                 295                 300                 


Asp Lys Leu Phe Leu Glu Asn Glu Glu Ala Thr Leu Lys Val Ala Ala 
305                 310                 315                 320 


Asp Val Met Lys Ser Tyr Gly Leu Pro Val Asn Arg Asn Thr Val Arg 
                325                 330                 335     


Leu His Asn Glu Phe Phe Gly Thr Ser Cys Pro His Arg Ser Trp Asp 
            340                 345                 350         


Leu His Val Gly Lys Gly Glu Pro Tyr Thr Thr Thr Asn Ile Asn Lys 
        355                 360                 365             


Met Lys Asp Tyr Phe Ile Lys Arg Ile Lys His Tyr Tyr Asp Gly Gly 
    370                 375                 380                 


Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp Val Lys 
385                 390                 395                 400 


Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala Thr Asp 
                405                 410                 415     


Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser 
            420                 425                 430         


Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro 
        435                 440                 445             


Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile 
    450                 455                 460                 


Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp 
465                 470                 475                 480 


Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp 
                485                 490                 495     


Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
            500                 505                 510 


<210>  85
<211>  1533
<212>  DNA
<213>  artificial

<220>
<223>  BuforinII-Ply2638A

<400>  85
atgacccgta gctctcgtgc tggcctgcag tttccggttg gtcgcgtgca ccgtctgctc     60

cgcaaaggat ccatgctaac tgctattgac tatcttacga aaaaaggttg gaaaatatca    120

tctgaccctc gcacttacga tggttaccct aaaaactacg gctacagaaa ttaccatgaa    180

aacggcatta attatgatga gttttgtggt ggttatcata gagcttttga tgtttacagt    240

aacgaaacta acgacgtgcc tgctgttact agcggaacag ttattgaagc aaacgattac    300

ggtaattttg gtggtacatt cgttattaga gacgctaacg ataacgattg gatatatggg    360

catctacaac gtggctcaat gcgatttgtt gtaggcgaca aagtcaatca aggtgacatt    420

attggtttac aaggtaatag caactattac gacaatccta tgagtgtaca tttacattta    480

caattacgcc ctaaagacgc aaagaaagat gaaaaatcac aagtatgtag tggtttggct    540

atggaaaaat atgacattac aaatttaaat gctaaacaag ataaatcaaa gaatgggagc    600

gtgaaagagt tgaaacatat ctattcaaac catattaaag gtaacaagat tacagcacca    660

aaacctagta ttcaaggtgt ggtcatccac aatgattatg gtagtatgac acctagtcaa    720

tacttaccat ggttatatgc acgtgagaat aacggtacac acgttaacgg ttgggctagt    780

gtttatgcaa atagaaacga agtgctttgg tatcatccga cagactacgt agagtggcat    840

tgtggtaatc aatgggcaaa tgctaactta atcggatttg aagtgtgtga gtcgtatcct    900

ggtagaatct cggacaaatt attcttagaa aatgaagaag cgacattgaa agtagctgcg    960

gatgtgatga agtcgtacgg attaccagtt aatcgcaaca ctgtacgtct gcataacgaa   1020

ttcttcggaa cttcttgtcc acatcgttcg tgggacttgc atgttggcaa aggtgagcct   1080

tacacaacta ctaatattaa taaaatgaaa gactacttca tcaaacgcat caaacattat   1140

tatgacggtg gaaagctaga agtaagcaaa gcagcaacta tcaaacaatc tgacgttaag   1200

caagaagtta aaaagcaaga agcaaaacaa attgtgaaag caacagattg gaaacagaat   1260

aaagatggca tttggtataa agctgaacat gcttcgttca cagtgacagc accagaggga   1320

attatcacaa gatacaaagg tccttggact ggtcacccac aagctggtgt attacaaaaa   1380

ggtcaaacga ttaaatatga tgaggttcaa aaatttgacg gtcatgtttg ggtatcgtgg   1440

gaaacgtttg agggcgaaac tgtatacatg ccggtacgca catgggacgc taaaactggt   1500

aaagttggta agttgtgggg cgaaattaaa tga                                1533


<210>  86
<211>  524
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-LL-37

<400>  86

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Leu Leu Gly Asp Phe Phe Arg Lys Ser 
                485                 490                 495     


Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile Lys 
            500                 505                 510         


Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
        515                 520                 


<210>  87
<211>  1575
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-LL-37

<400>  87
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cctcctgggt gacttctttc gcaaatccaa agagaaaatc   1500

ggcaaagagt tcaaacgtat cgtgcagcgc attaaagact ttctgcgtaa cctggttccg   1560

cgtaccgaat cttaa                                                    1575


<210>  88
<211>  516
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-SMAP-29

<400>  88

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Arg Gly Leu Arg Arg Leu Gly Arg Lys 
                485                 490                 495     


Ile Ala His Gly Val Lys Lys Tyr Gly Pro Thr Val Leu Arg Ile Ile 
            500                 505                 510         


Arg Ile Ala Gly 
        515     


<210>  89
<211>  1551
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-SMAP-29

<400>  89
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc ccgtggtctg cgtcgcctgg gtcgcaaaat tgcgcacggc   1500

gtcaaaaaat acggcccgac cgtgctgcgc attatccgca tcgctggtta a            1551


<210>  90
<211>  523
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Cecropin A (A.aegypti)

<400>  90

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Gly Gly Leu Lys Lys Leu Gly Lys Lys 
                485                 490                 495     


Leu Glu Gly Ala Gly Lys Arg Val Phe Asn Ala Ala Glu Lys Ala Leu 
            500                 505                 510         


Pro Val Val Ala Gly Ala Lys Ala Leu Arg Lys 
        515                 520             


<210>  91
<211>  1572
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Cecropin A (A.aegypti)

<400>  91
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cggcggcctg aaaaaactgg gcaaaaaact ggaaggtgcc   1500

ggcaaacgtg tgttcaacgc tgcagaaaaa gcactgccgg ttgtagctgg tgctaaagct   1560

ctccgtaaat aa                                                       1572


<210>  92
<211>  526
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Sarcotoxin IA

<400>  92

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Gly Trp Leu Lys Lys Ile Gly Lys Lys 
                485                 490                 495     


Ile Glu Arg Val Gly Gln His Thr Arg Asp Ala Thr Ile Gln Gly Leu 
            500                 505                 510         


Gly Ile Ala Gln Gln Ala Ala Asn Val Ala Ala Thr Ala Arg 
        515                 520                 525     


<210>  93
<211>  1581
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Sarcotoxin IA

<400>  93
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cggatggctc aaaaagattg gcaagaaaat cgagcgagtc   1500

ggtcagcata cgcgtgatgc aactatccag ggtttaggta tcgcacagca agcagctaat   1560

gtagcagcta ctgctcggta a                                             1581


<210>  94
<211>  541
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-OR-7

<400>  94

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Lys Thr Tyr Tyr Gly Thr Asn Gly Val 
                485                 490                 495     


His Cys Thr Lys Asn Ser Leu Trp Gly Lys Val Arg Leu Lys Asn Met 
            500                 505                 510         


Lys Tyr Asp Gln Asn Thr Thr Tyr Met Gly Arg Leu Gln Asp Ile Leu 
        515                 520                 525             


Leu Gly Trp Ala Thr Gly Ala Phe Gly Lys Thr Phe His 
    530                 535                 540     


<210>  95
<211>  1626
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-OR-7

<400>  95
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc caaaacctac tatggcacca acggcgtaca ctgcaccaaa   1500

aacagcctgt ggggtaaagt gcgtctgaaa aacatgaaat acgaccagaa caccacgtat   1560

atgggccgtc tccaggatat cctgctgggt tgggcaactg gtgccttcgg caaaaccttt   1620

cactaa                                                              1626


<210>  96
<211>  500
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Indolicidin

<400>  96

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Ile Leu Pro Trp Lys Trp Pro Trp Trp 
                485                 490                 495     


Pro Trp Arg Arg 
            500 


<210>  97
<211>  1503
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Indolicidin

<400>  97
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc catcctgccg tggaaatggc cgtggtggcc atggcgtcgc   1500

taa                                                                 1503


<210>  98
<211>  511
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Pseudin1

<400>  98

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Gly Leu Asn Thr Leu Lys Lys Val Phe 
                485                 490                 495     


Gln Gly Leu His Glu Ala Ile Lys Leu Ile Asn Asn His Val Gln 
            500                 505                 510     


<210>  99
<211>  1536
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Pseudin1

<400>  99
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cggtctgaac accctgaaaa aagtattcca gggtctgcat   1500

gaagcgatta aactgatcaa caaccacgtt cagtaa                             1536


<210>  100
<211>  510
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Magainin

<400>  100

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Gly Ile Gly Lys Phe Leu His Ser Ala 
                485                 490                 495     


Lys Lys Phe Gly Lys Ala Phe Val Gly Glu Ile Met Asn Ser 
            500                 505                 510 


<210>  101
<211>  1533
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Magainin

<400>  101
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cggtatcggc aaattcctgc actccgcaaa aaaattcggc   1500

aaagctttcg tgggcgaaat tatgaactct taa                                1533


<210>  102
<211>  512
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-Pleurocidin

<400>  102

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Gly Trp Gly Ser Phe Phe Lys Lys Ala 
                485                 490                 495     


Ala His Val Gly Lys His Val Gly Lys Ala Ala Leu Thr His Tyr Leu 
            500                 505                 510         


<210>  103
<211>  1539
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-Pleurocidin

<400>  103
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cggctggggt tctttcttta aaaaagcggc tcacgttggc   1500

aaacatgtag gtaaagcagc tctgacccac tatctgtaa                          1539


<210>  104
<211>  508
<212>  PRT
<213>  artificial

<220>
<223>  Ply2638A-BuforinII

<400>  104

Met Leu Thr Ala Ile Asp Tyr Leu Thr Lys Lys Gly Trp Lys Ile Ser 
1               5                   10                  15      


Ser Asp Pro Arg Thr Tyr Asp Gly Tyr Pro Lys Asn Tyr Gly Tyr Arg 
            20                  25                  30          


Asn Tyr His Glu Asn Gly Ile Asn Tyr Asp Glu Phe Cys Gly Gly Tyr 
        35                  40                  45              


His Arg Ala Phe Asp Val Tyr Ser Asn Glu Thr Asn Asp Val Pro Ala 
    50                  55                  60                  


Val Thr Ser Gly Thr Val Ile Glu Ala Asn Asp Tyr Gly Asn Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Val Ile Arg Asp Ala Asn Asp Asn Asp Trp Ile Tyr Gly 
                85                  90                  95      


His Leu Gln Arg Gly Ser Met Arg Phe Val Val Gly Asp Lys Val Asn 
            100                 105                 110         


Gln Gly Asp Ile Ile Gly Leu Gln Gly Asn Ser Asn Tyr Tyr Asp Asn 
        115                 120                 125             


Pro Met Ser Val His Leu His Leu Gln Leu Arg Pro Lys Asp Ala Lys 
    130                 135                 140                 


Lys Asp Glu Lys Ser Gln Val Cys Ser Gly Leu Ala Met Glu Lys Tyr 
145                 150                 155                 160 


Asp Ile Thr Asn Leu Asn Ala Lys Gln Asp Lys Ser Lys Asn Gly Ser 
                165                 170                 175     


Val Lys Glu Leu Lys His Ile Tyr Ser Asn His Ile Lys Gly Asn Lys 
            180                 185                 190         


Ile Thr Ala Pro Lys Pro Ser Ile Gln Gly Val Val Ile His Asn Asp 
        195                 200                 205             


Tyr Gly Ser Met Thr Pro Ser Gln Tyr Leu Pro Trp Leu Tyr Ala Arg 
    210                 215                 220                 


Glu Asn Asn Gly Thr His Val Asn Gly Trp Ala Ser Val Tyr Ala Asn 
225                 230                 235                 240 


Arg Asn Glu Val Leu Trp Tyr His Pro Thr Asp Tyr Val Glu Trp His 
                245                 250                 255     


Cys Gly Asn Gln Trp Ala Asn Ala Asn Leu Ile Gly Phe Glu Val Cys 
            260                 265                 270         


Glu Ser Tyr Pro Gly Arg Ile Ser Asp Lys Leu Phe Leu Glu Asn Glu 
        275                 280                 285             


Glu Ala Thr Leu Lys Val Ala Ala Asp Val Met Lys Ser Tyr Gly Leu 
    290                 295                 300                 


Pro Val Asn Arg Asn Thr Val Arg Leu His Asn Glu Phe Phe Gly Thr 
305                 310                 315                 320 


Ser Cys Pro His Arg Ser Trp Asp Leu His Val Gly Lys Gly Glu Pro 
                325                 330                 335     


Tyr Thr Thr Thr Asn Ile Asn Lys Met Lys Asp Tyr Phe Ile Lys Arg 
            340                 345                 350         


Ile Lys His Tyr Tyr Asp Gly Gly Lys Leu Glu Val Ser Lys Ala Ala 
        355                 360                 365             


Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala 
    370                 375                 380                 


Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile 
385                 390                 395                 400 


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
                405                 410                 415     


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
            420                 425                 430         


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
        435                 440                 445             


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
    450                 455                 460                 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
465                 470                 475                 480 


Leu Trp Gly Glu Ile Lys Ser Thr Arg Ser Ser Arg Ala Gly Leu Gln 
                485                 490                 495     


Phe Pro Val Gly Arg Val His Arg Leu Leu Arg Lys 
            500                 505             


<210>  105
<211>  1527
<212>  DNA
<213>  artificial

<220>
<223>  Ply2638A-BuforinII

<400>  105
atgctaactg ctattgacta tcttacgaaa aaaggttgga aaatatcatc tgaccctcgc     60

acttacgatg gttaccctaa aaactacggc tacagaaatt accatgaaaa cggcattaat    120

tatgatgagt tttgtggtgg ttatcataga gcttttgatg tttacagtaa cgaaactaac    180

gacgtgcctg ctgttactag cggaacagtt attgaagcaa acgattacgg taattttggt    240

ggtacattcg ttattagaga cgctaacgat aacgattgga tatatgggca tctacaacgt    300

ggctcaatgc gatttgttgt aggcgacaaa gtcaatcaag gtgacattat tggtttacaa    360

ggtaatagca actattacga caatcctatg agtgtacatt tacatttaca attacgccct    420

aaagacgcaa agaaagatga aaaatcacaa gtatgtagtg gtttggctat ggaaaaatat    480

gacattacaa atttaaatgc taaacaagat aaatcaaaga atgggagcgt gaaagagttg    540

aaacatatct attcaaacca tattaaaggt aacaagatta cagcaccaaa acctagtatt    600

caaggtgtgg tcatccacaa tgattatggt agtatgacac ctagtcaata cttaccatgg    660

ttatatgcac gtgagaataa cggtacacac gttaacggtt gggctagtgt ttatgcaaat    720

agaaacgaag tgctttggta tcatccgaca gactacgtag agtggcattg tggtaatcaa    780

tgggcaaatg ctaacttaat cggatttgaa gtgtgtgagt cgtatcctgg tagaatctcg    840

gacaaattat tcttagaaaa tgaagaagcg acattgaaag tagctgcgga tgtgatgaag    900

tcgtacggat taccagttaa tcgcaacact gtacgtctgc ataacgaatt cttcggaact    960

tcttgtccac atcgttcgtg ggacttgcat gttggcaaag gtgagcctta cacaactact   1020

aatattaata aaatgaaaga ctacttcatc aaacgcatca aacattatta tgacggtgga   1080

aagctagaag taagcaaagc agcaactatc aaacaatctg acgttaagca agaagttaaa   1140

aagcaagaag caaaacaaat tgtgaaagca acagattgga aacagaataa agatggcatt   1200

tggtataaag ctgaacatgc ttcgttcaca gtgacagcac cagagggaat tatcacaaga   1260

tacaaaggtc cttggactgg tcacccacaa gctggtgtat tacaaaaagg tcaaacgatt   1320

aaatatgatg aggttcaaaa atttgacggt catgtttggg tatcgtggga aacgtttgag   1380

ggcgaaactg tatacatgcc ggtacgcaca tgggacgcta aaactggtaa agttggtaag   1440

ttgtggggcg aaattaaatc cacccgtagc tctcgtgctg gcctgcagtt tccggttggt   1500

cgcgtgcacc gtctgctccg caaataa                                       1527


