                         SEQUENCE LISTING

<110>  Emergent Product Development Gaithersburg Inc.
       Blankenship, John W.
       Sewell, Elaine T.
       Tan, Philip
 
<120>  Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods

<130>  2479.102PC01/EJH

<140>  To be assigned
<141>  Herewith

<150>  61/478,449
<151>  2011-04-22

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  1
gagatccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gaagcagaac      120

aatggagaga gccttgagtg gattggatat tttaatcctt ataatgatta tactagatac      180

aaccagaatt tcaatggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcattct attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcg         357


<210>  2
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110     


<210>  3
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  3
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      120

gggaaagcta ataagcttct tatccattct ggatccactt tgcaatctgg aattccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      300

ggcaccaaac tggaaattaa acgggct                                          327


<210>  4
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified (mature) murine 107-1A4 VL domain used in construction 
       of chimeric sequences

<400>  4
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      120

gggaaagcta ataagctact tatccattct ggatccactt tgcaatctgg aataccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      300

ggcaccaaac tggaaattaa acgggcc                                          327


<210>  5
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  6
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  6
tctggataca cattcactga ctactacatg cac                                    33


<210>  7
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  7
tattttaatc cttataatga ttatactaga                                        30


<210>  8
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  8
tgtgcaagat cggatggtta ctacgatgct atggactact gg                          42


<210>  9
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  9

Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   10      


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg 
1               5                   10  


<210>  11
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  11

Cys Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp 
1               5                   10                  


<210>  12
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  12
aagagcatta gcaaatat                                                     18


<210>  13
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  13
tctggatcc                                                                9


<210>  14
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  14
caacagcata ttgaataccc gtggacg                                           27


<210>  15
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  15

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  16
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Gly Ser 
1           


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Gln His Ile Glu Tyr Pro Trp Thr 
1               5                   


<210>  18
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine scFv (VH-VL orientation)

<400>  18
gagatccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gaagcagaac      120

aatggagaga gccttgagtg gattggatat tttaatcctt ataatgatta tactagatac      180

aaccagaatt tcaatggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcattct attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcaggc      360

ggcggcggaa gcggcggtgg cggcagcagc ggcggcggcg gcagcgatgt ccagataacc      420

cagtctccat cttatcttgc tgcatctcct ggagaaacca ttactattaa ttgcagggca      480

agtaagagca ttagcaaata tttagcctgg tatcaagaga aacctgggaa agctaataag      540

ctacttatcc attctggatc cactttgcaa tctggaatac catcaaggtt cagtggcagt      600

ggatctggta cagatttcac tctcaccatc agtagcctgg agcctgaaga ttttgcaatg      660

tattactgtc aacagcatat tgaatacccg tggacgttcg gtggtggcac caaactggaa      720

attaaacggg cctcg                                                       735


<210>  19
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine scFv (VH-VL orientation)

<400>  19

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
    130                 135                 140                 


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
145                 150                 155                 160 


Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
                165                 170                 175     


Lys Ala Asn Lys Leu Leu Ile His Ser Gly Ser Thr Leu Gln Ser Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Ala Ser 
                245 


<210>  20
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine scFv (VL-VH orientation)

<400>  20
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      120

gggaaagcta ataagctact tatccattct ggatccactt tgcaatctgg aataccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      300

ggcaccaaac tggaaattaa acgggccggc ggcggcggaa gcggcggtgg cggcagcagc      360

ggcggcggcg gcagcgagat ccagctgcaa cagtctggac ctgagctggt gaagcctggg      420

gcttcagtga agatgtcctg caaggcttct ggatacacat tcactgacta ctacatgcac      480

tgggtgaagc agaacaatgg agagagcctt gagtggattg gatattttaa tccttataat      540

gattatacta gatacaacca gaatttcaat ggcaaggcca cattgactgt agacaagtcc      600

tccagcacag cctacatgca gctcaacagc ctgacatctg aggactctgc attctattac      660

tgtgcaagat cggatggtta ctacgatgct atggactact ggggtcaagg aacctcagtc      720

accgtctcct cg                                                          732


<210>  21
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine scFv (VL-VH orientation)

<400>  21

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Glu Ile Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
145                 150                 155                 160 


Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile Gly Tyr Phe 
                165                 170                 175     


Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe Asn Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  22
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized VL domain

<400>  22
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acga                                             324


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VL domain

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  24
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized VH domain #1

<400>  24
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaagatc       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcaacaggcc      120

cctggaaaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      180

gcagagaagt tccagggcag agtcaccata accgcggaca cgtctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcg         357


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VH domain #1

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized VH domain #2

<400>  26
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcttc agtgaaggtc       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtctatcag cacagcctac      240

atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcg         357


<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VH domain #2

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized scFv A (VL-VH#1 orientation)

<400>  28
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      360

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      420

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      480

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      540

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      600

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      660

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      720

tcctcg                                                                 726


<210>  29
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized scFv B (VL-VH#2 orientation)

<400>  29
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      360

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      420

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      480

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      540

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      600

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      660

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      720

tcctcg                                                                 726


<210>  30
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized scFv A (VL-VH#1 orientation)

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  31
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized scFv B (VL-VH#2 orientation)

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  32
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized scFv A (VH#1-VL orientation)

<400>  32
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaagatc       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcaacaggcc      120

cctggaaaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      180

gcagagaagt tccagggcag agtcaccata accgcggaca cgtctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      360

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      420

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      480

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      540

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      600

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      660

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      720

aaacgagcct cg                                                          732


<210>  33
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized scFv B (VH#2-VL orientation)

<400>  33
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcttc agtgaaggtc       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtctatcag cacagcctac      240

atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      360

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      420

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      480

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      540

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      600

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      660

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      720

aaacgcgcct cg                                                          732


<210>  34
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized scFv A (VH#1-VL orientation)

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser 
                


<210>  35
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized scFv B (VH#2-VL orientation)

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser 
                


<210>  36
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC085 chimeric SMIP (murine VL-VH scFv - human Fc)

<400>  36
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact      120

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      180

gggaaagcta ataagctact tatccattct ggatccactt tgcaatctgg aataccatca      240

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      300

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      360

ggcaccaaac tggaaattaa acgggccggc ggcggcggaa gcggcggtgg cggcagcagc      420

ggcggcggcg gcagcgagat ccagctgcaa cagtctggac ctgagctggt gaagcctggg      480

gcttcagtga agatgtcctg caaggcttct ggatacacat tcactgacta ctacatgcac      540

tgggtgaagc agaacaatgg agagagcctt gagtggattg gatattttaa tccttataat      600

gattatacta gatacaacca gaatttcaat ggcaaggcca cattgactgt agacaagtcc      660

tccagcacag cctacatgca gctcaacagc ctgacatctg aggactctgc attctattac      720

tgtgcaagat cggatggtta ctacgatgct atggactact ggggtcaagg aacctcagtc      780

accgtctcct cgagtgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1494


<210>  37
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC092 chimeric SMIP (murine VH-VL scFv - human Fc)

<400>  37
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagatccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg      120

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gaagcagaac      180

aatggagaga gccttgagtg gattggatat tttaatcctt ataatgatta tactagatac      240

aaccagaatt tcaatggcaa ggccacattg actgtagaca agtcctccag cacagcctac      300

atgcagctca acagcctgac atctgaggac tctgcattct attactgtgc aagatcggat      360

ggttactacg atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcaggc      420

ggcggcggaa gcggcggtgg cggcagcagc ggcggcggcg gcagcgatgt ccagataacc      480

cagtctccat cttatcttgc tgcatctcct ggagaaacca ttactattaa ttgcagggca      540

agtaagagca ttagcaaata tttagcctgg tatcaagaga aacctgggaa agctaataag      600

ctacttatcc attctggatc cactttgcaa tctggaatac catcaaggtt cagtggcagt      660

ggatctggta cagatttcac tctcaccatc agtagcctgg agcctgaaga ttttgcaatg      720

tattactgtc aacagcatat tgaatacccg tggacgttcg gtggtggcac caaactggaa      780

attaaacggg cctcgagtga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      840

ccagcacctg aagccgcggg tgcaccgtca gtcttcctct tccccccaaa acccaaggac      900

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      960

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1020

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1080

caccaggact ggctgaatgg caaggcgtac gcgtgcgcgg tctccaacaa agccctccca     1140

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1200

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1260

aaaggcttct atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1320

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1380

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1440

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        1497


<210>  38
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC085 chimeric SMIP (murine VL-VH scFv - human Fc)

<400>  38

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Glu Ile Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
145                 150                 155                 160 


Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile Gly Tyr Phe 
                165                 170                 175     


Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe Asn Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  39
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC092 chimeric SMIP (murine VH-VL scFv - human Fc)

<400>  39

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
    130                 135                 140                 


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
145                 150                 155                 160 


Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
                165                 170                 175     


Lys Ala Asn Lys Leu Leu Ile His Ser Gly Ser Thr Leu Gln Ser Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  40
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC188 humanized SMIP (human VL-VH#1 scFv-Fc)

<400>  40
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1488


<210>  41
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC189 humanized SMIP (human VL-VH#2 scFv-Fc)

<400>  41
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1488


<210>  42
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC188 humanized SMIP (human VL-VH#1 scFv-Fc)

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  43
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC189 humanized SMIP (human VL-VH#2 scFv-Fc)

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  44
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric TSC084 Interceptor (murine VL-VH 107-1A4 scFv-Fc-CH1)

<400>  44
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact      120

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      180

gggaaagcta ataagctact tatccattct ggatccactt tgcaatctgg aataccatca      240

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      300

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      360

ggcaccaaac tggaaattaa acgggccggc ggcggcggaa gcggcggtgg cggcagcagc      420

ggcggcggcg gcagcgagat ccagctgcaa cagtctggac ctgagctggt gaagcctggg      480

gcttcagtga agatgtcctg caaggcttct ggatacacat tcactgacta ctacatgcac      540

tgggtgaagc agaacaatgg agagagcctt gagtggattg gatattttaa tccttataat      600

gattatacta gatacaacca gaatttcaat ggcaaggcca cattgactgt agacaagtcc      660

tccagcacag cctacatgca gctcaacagc ctgacatctg aggactctgc attctattac      720

tgtgcaagat cggatggtta ctacgatgct atggactact ggggtcaagg aacctcagtc      780

accgtctcct cgagcgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atctagagcc     1500

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     1560

acagcggccc tgggctgcct ggtcaaggac tacttccccg agccggtgac ggtgtcgtgg     1620

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     1680

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     1740

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt ttga           1794


<210>  45
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC093 Interceptor (Cris7 scFv-Fc-CkYAE)

<400>  45
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg      120

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      180

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      240

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      300

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      360

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      420

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      480

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      540

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc      600

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      660

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      720

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      780

ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      840

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct     1500

agaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct     1560

ggaactgcct ctgttgtgtg cctgctgaat tacttctatc ccagagaggc caaagtacag     1620

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgccac agagcaggac     1680

agcaaggaca gcacctacag cctcagcagc gagctgacgc tgagcaaagc agactacgag     1740

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag     1800

agcttcaaca ggggagagtg a                                               1821


<210>  46
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC084 Interceptor (murine VL-VH 107-1A4 scFv-Fc-CH1)

<400>  46

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Glu Ile Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
145                 150                 155                 160 


Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile Gly Tyr Phe 
                165                 170                 175     


Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe Asn Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala 
465                 470                 475                 480 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                485                 490                 495     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            500                 505                 510         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        515                 520                 525             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
545                 550                 555                 560 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                565                 570                 575     


Val 
    


<210>  47
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC093 Interceptor (Cris7 scFv-Fc-CkYAE)

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                485                 490                 495     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe 
            500                 505                 510         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        515                 520                 525             


Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser 
    530                 535                 540                 


Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
545                 550                 555                 560 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                565                 570                 575     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585     


<210>  48
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC194 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-Cris7 scFv)

<400>  48
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

cagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg aaagggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagcccggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacacga     2280

taa                                                                   2283


<210>  49
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC194 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-Cris7 scFv)

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Arg 
            740 


<210>  50
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC199 Scorpion (huVL-VH#1 107-1A4 scFv-Fc-Cris7 scFv)

<400>  50
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

cagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg aaagggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagcccggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacacga     2280

taa                                                                   2283


<210>  51
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC199 Scorpion (huVL-VH#1 107-1A4 scFv-Fc-Cris7 scFv)

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Arg 
            740 


<210>  52
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC125 Interceptor (Cris7 scFv-Fc-CH1)

<400>  52
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg      120

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      180

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      240

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      300

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      360

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      420

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      480

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      540

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc      600

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      660

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      720

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      780

ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      840

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct     1500

agagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagtttga     1800


<210>  53
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC192 Interceptor (huVL-VH#2 107-1A4 scFv-Fc-CkYAE)

<400>  53
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag aactgtggct     1500

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     1560

gttgtgtgcc tgctgaatta cttctatccc agagaggcca aagtacagtg gaaggtggat     1620

aacgccctcc aatcgggtaa ctcccaggag agtgccacag agcaggacag caaggacagc     1680

acctacagcc tcagcagcga gctgacgctg agcaaagcag actacgagaa acacaaagtc     1740

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1800

ggagagtga                                                             1809


<210>  54
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC193 Interceptor (huVL-VH#1 107-1A4 scFv-Fc-CkYAE)

<400>  54
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag aactgtggct     1500

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     1560

gttgtgtgcc tgctgaatta cttctatccc agagaggcca aagtacagtg gaaggtggat     1620

aacgccctcc aatcgggtaa ctcccaggag agtgccacag agcaggacag caaggacagc     1680

acctacagcc tcagcagcga gctgacgctg agcaaagcag actacgagaa acacaaagtc     1740

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1800

ggagagtga                                                             1809


<210>  55
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC195 Interceptor (huVL-VH#2 107-1A4 scFv-Fc-CH1)

<400>  55
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag agcctccacc     1500

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     1560

gccctgggct gcctggtcaa ggactacttc cccgagccgg tgacggtgtc gtggaactca     1620

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     1680

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     1740

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagtttga                  1788


<210>  56
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized TSC196 Interceptor (huVL-VH#1 107-1A4 scFv-Fc-CH1)

<400>  56
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag agcctccacc     1500

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     1560

gccctgggct gcctggtcaa ggactacttc cccgagccgg tgacggtgtc gtggaactca     1620

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     1680

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     1740

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagtttga                  1788


<210>  57
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC125 Interceptor (Cris7 scFv-Fc-CH1)

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                485                 490                 495     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            500                 505                 510         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        515                 520                 525             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    530                 535                 540                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
545                 550                 555                 560 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                565                 570                 575     


Lys Lys Val 
            


<210>  58
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC192 Interceptor (huVL-VH#2 107-1A4 scFv-Fc-CkYAE)

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu 
            580         


<210>  59
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC193 Interceptor (huVL-VH#1 107-1A4 scFv-Fc-CkYAE)

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu 
            580         


<210>  60
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC195 Interceptor (huVL-VH#2 107-1A4 scFv-Fc-CH1)

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                485                 490                 495     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            500                 505                 510         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        515                 520                 525             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    530                 535                 540                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
545                 550                 555                 560 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                565                 570                 575 


<210>  61
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized TSC196 Interceptor (huVL-VH#1 107-1A4 scFv-Fc-CH1)

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                485                 490                 495     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            500                 505                 510         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        515                 520                 525             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    530                 535                 540                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
545                 550                 555                 560 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                565                 570                 575 


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H7

<400>  62

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  63
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H75

<400>  63

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H81

<400>  64

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H83

<400>  65

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  66
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H91

<400>  66

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  67
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H94

<400>  67

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker H98

<400>  68

Ser Ser Leu Asn Thr Gly Thr Gln Pro Asn Ser 
1               5                   10      


<210>  69
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC210-humanized SMIP (human VH#2-VL scFv-Fc)

<400>  69
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcttc agtgaaggtc      120

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcgacaggcc      180

cctggacaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      240

gcacagaagt tccagggcag agtcaccatg accagggaca cgtctatcag cacagcctac      300

atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc aagatcggat      360

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      420

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      480

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      540

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      600

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      660

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      720

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      780

aaacgcgcct cgagtgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1494


<210>  70
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC210-humanized SMIP (human VH#2-VL scFv-Fc)

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  71
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC211 humanized SMIP (human VH#1-VL scFv-Fc)

<400>  71
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaagatc      120

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcaacaggcc      180

cctggaaaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      240

gcagagaagt tccagggcag agtcaccata accgcggaca cgtctacaga cacagcctac      300

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagatcggat      360

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      420

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      480

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      540

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      600

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      660

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      720

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      780

aaacgagcct cgagtgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1494


<210>  72
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC211 humanized SMIP (human VH#1-VL scFv-Fc)

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  73
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC212 Scorpion (hu VH#2-VL 107-1A4 scFv-Fc Cris7 scFv)

<400>  73
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcttc agtgaaggtc      120

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcgacaggcc      180

cctggacaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      240

gcacagaagt tccagggcag agtcaccatg accagggaca cgtctatcag cacagcctac      300

atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc aagatcggat      360

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      420

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      480

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      540

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      600

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      660

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      720

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      780

aaacgcgcct cgagtgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtca gaggcacaac     1500

aattcttccc tgaatacagg aactcagatg gcaggtcatt ctccgaattc tcaggtccag     1560

ctggtgcagt ctgggggcgg agtggtgcag cctgggcggt cactgaggct gtcctgcaag     1620

gcttctggct acacctttac tagatctacg atgcactggg taaggcaggc ccctggaaag     1680

ggtctggaat ggattggata cattaatcct agcagtgctt atactaatta caatcagaaa     1740

ttcaaggaca ggttcacaat cagcgcagac aaatccaaga gcacagcctt cctgcagatg     1800

gacagcctga ggcccgagga caccggcgtc tatttctgtg cacggcccca agtccactat     1860

gattacaacg ggtttcctta ctggggccaa gggactcccg tcactgtctc tagcggtggc     1920

ggagggtctg ggggtggcgg atccggaggt ggtggctctg cacaagacat ccagatgacc     1980

cagtctccaa gcagcctgtc tgcaagcgtg ggggacaggg tcaccatgac ctgcagtgcc     2040

agctcaagtg taagttacat gaactggtac cagcagaagc ccggcaaggc ccccaaaaga     2100

tggatttatg actcatccaa actggcttct ggagtccctg ctcgcttcag tggcagtggg     2160

tctgggaccg actataccct cacaatcagc agcctgcagc ccgaagattt cgccacttat     2220

tactgccagc agtggagtcg taacccaccc acgttcggag gggggaccaa gctacaaatt     2280

acacgataa                                                             2289



<210>  74
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC212 Scorpion (huVH#2-VL 107-1A4 scFv-Fc-Cris7 scFv)

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn 
465                 470                 475                 480 


Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn 
                485                 490                 495     


Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly 
            500                 505                 510         


Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        515                 520                 525             


Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    530                 535                 540                 


Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys 
545                 550                 555                 560 


Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala 
                565                 570                 575     


Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe 
            580                 585                 590         


Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp 
        595                 600                 605             


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr 
625                 630                 635                 640 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
                645                 650                 655     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            660                 665                 670         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
        675                 680                 685             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
705                 710                 715                 720 


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Gln Ile Thr Arg 
            740         


<210>  75
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC213 Scorpion (huVH#1-VL 107-1A4 scFv-FcCris7 scFv)

<400>  75
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaagatc      120

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcaacaggcc      180

cctggaaaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      240

gcagagaagt tccagggcag agtcaccata accgcggaca cgtctacaga cacagcctac      300

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagatcggat      360

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcaggt      420

ggcggagggt ctgggggtgg cggatccgga ggtggtggct ctgatatcca gatgacccag      480

tctccatccg ccatgtctgc atctgtagga gacagagtca ccatcacttg ccgggcgagt      540

aagagcatta gcaaatattt agcctggttt cagcagaaac cagggaaagt tcctaagctc      600

cgcatccatt ctggatctac tttgcaatca ggggtcccat ctcggttcag tggcagtgga      660

tctgggacag aatttactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      720

tactgtcaac agcatattga atacccgtgg acgttcggcc aagggaccaa ggtggaaatc      780

aaacgagcct cgagtgagcc caaatcttct gacaaaactc acacatgccc accgtgccca      840

gcacctgaag ccgcgggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      900

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      960

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1020

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1080

caggactggc tgaatggcaa ggcgtacgcg tgcgcggtct ccaacaaagc cctcccagcc     1140

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1200

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1260

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1320

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1380

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1440

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtca gaggcacaac     1500

aattcttccc tgaatacagg aactcagatg gcaggtcatt ctccgaattc tcaggtccag     1560

ctggtgcagt ctgggggcgg agtggtgcag cctgggcggt cactgaggct gtcctgcaag     1620

gcttctggct acacctttac tagatctacg atgcactggg taaggcaggc ccctggaaag     1680

ggtctggaat ggattggata cattaatcct agcagtgctt atactaatta caatcagaaa     1740

ttcaaggaca ggttcacaat cagcgcagac aaatccaaga gcacagcctt cctgcagatg     1800

gacagcctga ggcccgagga caccggcgtc tatttctgtg cacggcccca agtccactat     1860

gattacaacg ggtttcctta ctggggccaa gggactcccg tcactgtctc tagcggtggc     1920

ggagggtctg ggggtggcgg atccggaggt ggtggctctg cacaagacat ccagatgacc     1980

cagtctccaa gcagcctgtc tgcaagcgtg ggggacaggg tcaccatgac ctgcagtgcc     2040

agctcaagtg taagttacat gaactggtac cagcagaagc ccggcaaggc ccccaaaaga     2100

tggatttatg actcatccaa actggcttct ggagtccctg ctcgcttcag tggcagtggg     2160

tctgggaccg actataccct cacaatcagc agcctgcagc ccgaagattt cgccacttat     2220

tactgccagc agtggagtcg taacccaccc acgttcggag gggggaccaa gctacaaatt     2280

acacgataa                                                             2289


<210>  76
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC213 Scorpion (huVH#1-VL 107-1A4 scFv-Fc-Cris7 scFv)

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
    130                 135                 140                 


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn 
465                 470                 475                 480 


Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn 
                485                 490                 495     


Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly 
            500                 505                 510         


Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        515                 520                 525             


Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    530                 535                 540                 


Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys 
545                 550                 555                 560 


Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala 
                565                 570                 575     


Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe 
            580                 585                 590         


Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp 
        595                 600                 605             


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr 
625                 630                 635                 640 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
                645                 650                 655     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            660                 665                 670         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
        675                 680                 685             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
705                 710                 715                 720 


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Gln Ile Thr Arg 
            740         


<210>  77
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC249 Scorpion (huVL-VH#2 107-1A4 scFv-FC-DRA222 scFv)

<400>  77
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

gagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg acaaggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     2280

tccagctaa                                                             2289


<210>  78
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC249 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv)

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Ser Ser Ser 
            740         


<210>  79
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC250 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H81 linker)

<400>  79
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtgaagttca aattcccttg     1500

accgaaagtt acagcccgaa ttctcaggtc cagctggtgg agtctggggg cggagtggtg     1560

cagcctgggc ggtcactgag gctgtcctgc aaggcttctg gctacacctt tactagatct     1620

acgatgcact gggtaaggca ggcccctgga caaggtctgg aatggattgg atacattaat     1680

cctagcagtg cttatactaa ttacaatcag aaattcaagg acaggttcac aatcagcgca     1740

gacaaatcca agagcacagc cttcctgcag atggacagcc tgaggcccga ggacaccggc     1800

gtctatttct gtgcacggcc ccaagtccac tatgattaca acgggtttcc ttactggggc     1860

caagggactc ccgtcactgt ctctagcggt ggcggagggt ctgggggtgg cggatccgga     1920

ggtggtggct ctgcacaaga catccagatg acccagtctc caagcagcct gtctgcaagc     1980

gtgggggaca gggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgaactgg     2040

taccagcaga agccgggcaa ggcccccaaa agatggattt atgactcatc caaactggct     2100

tctggagtcc ctgctcgctt cagtggcagt gggtctggga ccgactatac cctcacaatc     2160

agcagcctgc agcccgaaga tttcgccact tattactgcc agcagtggag tcgtaaccca     2220

cccacgttcg gaggggggac caagctacaa attacatcct ccagctaa                  2268


<210>  80
<211>  1335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC250 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H81 linker)

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Glu Val Gln Ile Pro Leu 
465                 470                 475                 480 


Thr Glu Ser Tyr Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly 
                485                 490                 495     


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
            500                 505                 510         


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
        515                 520                 525             


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
    530                 535                 540                 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
545                 550                 555                 560 


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
                565                 570                 575     


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
            580                 585                 590         


Tyr Asn Gly Phe Pro Tyr Trp Gly Asp Ile Gln Met Thr Gln Ser Pro 
        595                 600                 605             


Ser Ala Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
    610                 615                 620                 


Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro 
625                 630                 635                 640 


Gly Lys Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser 
                645                 650                 655     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
            660                 665                 670         


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        675                 680                 685             


Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
    690                 695                 700                 


Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
                725                 730                 735     


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            740                 745                 750         


Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        755                 760                 765             


Glu Trp Met Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala 
    770                 775                 780                 


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
785                 790                 795                 800 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val 
                805                 810                 815     


Tyr Tyr Cys Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp 
            820                 825                 830         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser 
        835                 840                 845             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
    850                 855                 860                 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
865                 870                 875                 880 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                885                 890                 895     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            900                 905                 910         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        915                 920                 925             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    930                 935                 940                 


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
945                 950                 955                 960 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                965                 970                 975     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            980                 985                 990         


Leu Thr Cys Leu Val Lys Gly Phe  Tyr Pro Ser Asp Ile  Ala Val Glu 
        995                 1000                 1005             


Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
    1010                 1015                 1020             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
    1025                 1030                 1035             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1040                 1045                 1050             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1055                 1060                 1065             


Leu Ser  Leu Ser Pro Gly Glu  Val Gln Ile Pro Leu  Thr Glu Ser 
    1070                 1075                 1080             


Tyr Ser  Pro Asn Ser Gln Val  Gln Leu Val Glu Ser  Gly Gly Gly 
    1085                 1090                 1095             


Val Val  Gln Pro Gly Arg Ser  Leu Arg Leu Ser Cys  Lys Ala Ser 
    1100                 1105                 1110             


Gly Tyr  Thr Phe Thr Arg Ser  Thr Met His Trp Val  Arg Gln Ala 
    1115                 1120                 1125             


Pro Gly  Gln Gly Leu Glu Trp  Ile Gly Tyr Ile Asn  Pro Ser Ser 
    1130                 1135                 1140             


Ala Tyr  Thr Asn Tyr Asn Gln  Lys Phe Lys Asp Arg  Phe Thr Ile 
    1145                 1150                 1155             


Ser Ala  Asp Lys Ser Lys Ser  Thr Ala Phe Leu Gln  Met Asp Ser 
    1160                 1165                 1170             


Leu Arg  Pro Glu Asp Thr Gly  Val Tyr Phe Cys Ala  Arg Pro Gln 
    1175                 1180                 1185             


Val His  Tyr Asp Tyr Asn Gly  Phe Pro Tyr Trp Gly  Gln Gly Thr 
    1190                 1195                 1200             


Pro Val  Thr Val Ser Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1205                 1210                 1215             


Ser Gly  Gly Gly Gly Ser Ala  Gln Asp Ile Gln Met  Thr Gln Ser 
    1220                 1225                 1230             


Pro Ser  Ser Leu Ser Ala Ser  Val Gly Asp Arg Val  Thr Met Thr 
    1235                 1240                 1245             


Cys Ser  Ala Ser Ser Ser Val  Ser Tyr Met Asn Trp  Tyr Gln Gln 
    1250                 1255                 1260             


Lys Pro  Gly Lys Ala Pro Lys  Arg Trp Ile Tyr Asp  Ser Ser Lys 
    1265                 1270                 1275             


Leu Ala  Ser Gly Val Pro Ala  Arg Phe Ser Gly Ser  Gly Ser Gly 
    1280                 1285                 1290             


Thr Asp  Tyr Thr Leu Thr Ile  Ser Ser Leu Gln Pro  Glu Asp Phe 
    1295                 1300                 1305             


Ala Thr  Tyr Tyr Cys Gln Gln  Trp Ser Arg Asn Pro  Pro Thr Phe 
    1310                 1315                 1320             


Gly Gly  Gly Thr Lys Leu Gln  Ile Thr Ser Ser Ser  
    1325                 1330                 1335 


<210>  81
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC251 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H83 linker)

<400>  81
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttcttccct gaatacagga     1500

actcagatgg caggtcattc tccgaattct caggtccagc tggtggagtc tgggggcgga     1560

gtggtgcagc ctgggcggtc actgaggctg tcctgcaagg cttctggcta cacctttact     1620

agatctacga tgcactgggt aaggcaggcc cctggacaag gtctggaatg gattggatac     1680

attaatccta gcagtgctta tactaattac aatcagaaat tcaaggacag gttcacaatc     1740

agcgcagaca aatccaagag cacagccttc ctgcagatgg acagcctgag gcccgaggac     1800

accggcgtct atttctgtgc acggccccaa gtccactatg attacaacgg gtttccttac     1860

tggggccaag ggactcccgt cactgtctct agcggtggcg gagggtctgg gggtggcgga     1920

tccggaggtg gtggctctgc acaagacatc cagatgaccc agtctccaag cagcctgtct     1980

gcaagcgtgg gggacagggt caccatgacc tgcagtgcca gctcaagtgt aagttacatg     2040

aactggtacc agcagaagcc gggcaaggcc cccaaaagat ggatttatga ctcatccaaa     2100

ctggcttctg gagtccctgc tcgcttcagt ggcagtgggt ctgggaccga ctataccctc     2160

acaatcagca gcctgcagcc cgaagatttc gccacttatt actgccagca gtggagtcgt     2220

aacccaccca cgttcggagg ggggaccaag ctacaaatta catcctccag ctaa           2274


<210>  82
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC251 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H83 linker)

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Leu Asn Thr Gly 
465                 470                 475                 480 


Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu 
                485                 490                 495     


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    530                 535                 540                 


Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
545                 550                 555                 560 


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
                565                 570                 575     


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His 
            580                 585                 590         


Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
625                 630                 635                 640 


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
                645                 650                 655     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            660                 665                 670         


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
705                 710                 715                 720 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
                725                 730                 735     


Ser 
    


<210>  83
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC252 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H91 linker)

<400>  83
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaactcatt agcaaaccaa     1500

gaagttcaaa ttcccttgac cgaaagttac agcccgaatt ctcaggtcca gctggtggag     1560

tctgggggcg gagtggtgca gcctgggcgg tcactgaggc tgtcctgcaa ggcttctggc     1620

tacaccttta ctagatctac gatgcactgg gtaaggcagg cccctggaca aggtctggaa     1680

tggattggat acattaatcc tagcagtgct tatactaatt acaatcagaa attcaaggac     1740

aggttcacaa tcagcgcaga caaatccaag agcacagcct tcctgcagat ggacagcctg     1800

aggcccgagg acaccggcgt ctatttctgt gcacggcccc aagtccacta tgattacaac     1860

gggtttcctt actggggcca agggactccc gtcactgtct ctagcggtgg cggagggtct     1920

gggggtggcg gatccggagg tggtggctct gcacaagaca tccagatgac ccagtctcca     1980

agcagcctgt ctgcaagcgt gggggacagg gtcaccatga cctgcagtgc cagctcaagt     2040

gtaagttaca tgaactggta ccagcagaag ccgggcaagg cccccaaaag atggatttat     2100

gactcatcca aactggcttc tggagtccct gctcgcttca gtggcagtgg gtctgggacc     2160

gactataccc tcacaatcag cagcctgcag cccgaagatt tcgccactta ttactgccag     2220

cagtggagtc gtaacccacc cacgttcgga ggggggacca agctacaaat tacatcctcc     2280

agctaa                                                                2286


<210>  84
<211>  1478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC252 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H91 linker)

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Leu Asn Thr Gly 
465                 470                 475                 480 


Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu 
                485                 490                 495     


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    530                 535                 540                 


Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
545                 550                 555                 560 


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
                565                 570                 575     


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His 
            580                 585                 590         


Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
625                 630                 635                 640 


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
                645                 650                 655     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            660                 665                 670         


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
705                 710                 715                 720 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
                725                 730                 735     


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val 
            740                 745                 750         


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys 
        755                 760                 765             


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg 
    770                 775                 780                 


Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
785                 790                 795                 800 


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                805                 810                 815     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro 
            820                 825                 830         


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
        835                 840                 845             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    850                 855                 860                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
865                 870                 875                 880 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp 
                885                 890                 895     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn 
            900                 905                 910         


Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val 
        915                 920                 925             


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
    930                 935                 940                 


Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp 
945                 950                 955                 960 


Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                965                 970                 975     


Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            980                 985                 990         


Pro Cys Pro Ala Pro Glu Ala Ala  Gly Ala Pro Ser Val  Phe Leu Phe 
        995                 1000                 1005             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1010                 1015                 1020             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1025                 1030                 1035             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1040                 1045                 1050             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1055                 1060                 1065             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Ala 
    1070                 1075                 1080             


Tyr Ala  Cys Ala Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1085                 1090                 1095             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1100                 1105                 1110             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1115                 1120                 1125             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1130                 1135                 1140             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1145                 1150                 1155             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1160                 1165                 1170             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1175                 1180                 1185             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1190                 1195                 1200             


Lys Ser  Leu Ser Leu Ser Pro  Gly Asn Ser Leu Ala  Asn Gln Glu 
    1205                 1210                 1215             


Val Gln  Ile Pro Leu Thr Glu  Ser Tyr Ser Pro Asn  Ser Gln Val 
    1220                 1225                 1230             


Gln Leu  Val Glu Ser Gly Gly  Gly Val Val Gln Pro  Gly Arg Ser 
    1235                 1240                 1245             


Leu Arg  Leu Ser Cys Lys Ala  Ser Gly Tyr Thr Phe  Thr Arg Ser 
    1250                 1255                 1260             


Thr Met  His Trp Val Arg Gln  Ala Pro Gly Gln Gly  Leu Glu Trp 
    1265                 1270                 1275             


Ile Gly  Tyr Ile Asn Pro Ser  Ser Ala Tyr Thr Asn  Tyr Asn Gln 
    1280                 1285                 1290             


Lys Phe  Lys Asp Arg Phe Thr  Ile Ser Ala Asp Lys  Ser Lys Ser 
    1295                 1300                 1305             


Thr Ala  Phe Leu Gln Met Asp  Ser Leu Arg Pro Glu  Asp Thr Gly 
    1310                 1315                 1320             


Val Tyr  Phe Cys Ala Arg Pro  Gln Val His Tyr Asp  Tyr Asn Gly 
    1325                 1330                 1335             


Phe Pro  Tyr Trp Gly Gln Gly  Thr Pro Val Thr Val  Ser Ser Gly 
    1340                 1345                 1350             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala 
    1355                 1360                 1365             


Gln Asp  Ile Gln Met Thr Gln  Ser Pro Ser Ser Leu  Ser Ala Ser 
    1370                 1375                 1380             


Val Gly  Asp Arg Val Thr Met  Thr Cys Ser Ala Ser  Ser Ser Val 
    1385                 1390                 1395             


Ser Tyr  Met Asn Trp Tyr Gln  Gln Lys Pro Gly Lys  Ala Pro Lys 
    1400                 1405                 1410             


Arg Trp  Ile Tyr Asp Ser Ser  Lys Leu Ala Ser Gly  Val Pro Ala 
    1415                 1420                 1425             


Arg Phe  Ser Gly Ser Gly Ser  Gly Thr Asp Tyr Thr  Leu Thr Ile 
    1430                 1435                 1440             


Ser Ser  Leu Gln Pro Glu Asp  Phe Ala Thr Tyr Tyr  Cys Gln Gln 
    1445                 1450                 1455             


Trp Ser  Arg Asn Pro Pro Thr  Phe Gly Gly Gly Thr  Lys Leu Gln 
    1460                 1465                 1470             


Ile Thr  Ser Ser Ser 
    1475             


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  85

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  86
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuM291 VL amino acid sequence

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  87
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuM291 VH amino acid sequence

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(s)-hlgG1 hinge

<400>  88

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(s)-hlgG1 hinge

<400>  89

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(s)-hlgG1 hinge

<400>  90

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(s)-hlgG1 hinge

<400>  91

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(s)-hlgG1 hinge

<400>  92

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(s)-hlgG1 hinge

<400>  93

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(s)-hlgG1 hinge

<400>  94

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(p)-hlgG1 hinge

<400>  95

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(p)-hlgG1 hinge

<400>  96

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(p)-hlgG1 hinge

<400>  97

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(p)-hlgG1 hinge

<400>  98

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(p)-hlgG1 hinge

<400>  99

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(p)-hlgG1 hinge

<400>  100

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(p)-hlgG1 hinge

<400>  101

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scppcp

<400>  102

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  103
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD1

<400>  103

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  104
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD2

<400>  104

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  105
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1

<400>  105

Asn Ser 
1       


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2

<400>  106

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3

<400>  107

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4

<400>  108

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5

<400>  109

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  110
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H6

<400>  110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3

<400>  111

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GAS)4

<400>  112

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H16

<400>  113

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  114
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H17

<400>  114

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H18

<400>  115

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H19

<400>  116

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H20

<400>  117

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  118
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H21

<400>  118

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H22

<400>  119

Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  120
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H23

<400>  120

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H24

<400>  121

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  122
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H25

<400>  122

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H26

<400>  123

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  124
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H27

<400>  124

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H28

<400>  125

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H30

<400>  126

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H32

<400>  127

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  128
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H33

<400>  128

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H36

<400>  129

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H40

<400>  130

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H41

<400>  131

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H42

<400>  132

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H44

<400>  133

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H45

<400>  134

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H46

<400>  135

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H47

<400>  136

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H48

<400>  137

Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10      


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H50

<400>  138

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  139
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H51

<400>  139

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H52

<400>  140

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H53

<400>  141

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H54

<400>  142

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H55

<400>  143

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H56

<400>  144

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H57

<400>  145

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  146
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H58

<400>  146

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H59

<400>  147

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  148
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H60

<400>  148

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  149
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H61

<400>  149

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  150
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H62

<400>  150

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  151
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H63

<400>  151

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  152

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid

<400>  153

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  154
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid

<400>  154

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  155
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge region H-105

<400>  155

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  156
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Region H106 (NKG2A derived)

<400>  156

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  157
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC95 Scorpion (hu VL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H9 linker)

<400>  157
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtgggagccc accttcaccg     1500

aattctcagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg     1560

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg     1620

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact     1680

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca     1740

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg     1800

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact     1860

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa     1920

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc     1980

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc     2040

aaggccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc     2100

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa     2160

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacgtt cggagggggg     2220

accaagctac aaattacatc ctccagctaa                                      2250


<210>  158
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC295 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H9 linker)

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Pro Ser Pro 
465                 470                 475                 480 


Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                485                 490                 495     


Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
    530                 535                 540                 


Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr 
545                 550                 555                 560 


Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr 
                565                 570                 575     


Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met 
    610                 615                 620                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
625                 630                 635                 640 


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                645                 650                 655     


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
            660                 665                 670         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        675                 680                 685             


Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    690                 695                 700                 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
705                 710                 715                 720 


Thr Lys Leu Gln Ile Thr Ser Ser Ser 
                725                 


<210>  159
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC296 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H94 linker)

<400>  159
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctggtgg aggcggttca     1500

ggcggaggtg gctccggcgg tggcggatcg ccgaattctc aggtccagct ggtggagtct     1560

gggggcggag tggtgcagcc tgggcggtca ctgaggctgt cctgcaaggc ttctggctac     1620

acctttacta gatctacgat gcactgggta aggcaggccc ctggacaagg tctggaatgg     1680

attggataca ttaatcctag cagtgcttat actaattaca atcagaaatt caaggacagg     1740

ttcacaatca gcgcagacaa atccaagagc acagccttcc tgcagatgga cagcctgagg     1800

cccgaggaca ccggcgtcta tttctgtgca cggccccaag tccactatga ttacaacggg     1860

tttccttact ggggccaagg gactcccgtc actgtctcta gcggtggcgg agggtctggg     1920

ggtggcggat ccggaggtgg tggctctgca caagacatcc agatgaccca gtctccaagc     1980

agcctgtctg caagcgtggg ggacagggtc accatgacct gcagtgccag ctcaagtgta     2040

agttacatga actggtacca gcagaagccg ggcaaggccc ccaaaagatg gatttatgac     2100

tcatccaaac tggcttctgg agtccctgct cgcttcagtg gcagtgggtc tgggaccgac     2160

tataccctca caatcagcag cctgcagccc gaagatttcg ccacttatta ctgccagcag     2220

tggagtcgta acccacccac gttcggaggg gggaccaagc tacaaattac atcctccagc     2280

taa                                                                   2283


<210>  160
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC296 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H94 linker)

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Asn Ser Gln Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met 
                565                 570                 575     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro 
            580                 585                 590         


Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
        595                 600                 605             


Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala 
                645                 650                 655     


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            660                 665                 670         


Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val 
        675                 680                 685             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    690                 695                 700                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
705                 710                 715                 720 


Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile 
                725                 730                 735     


Thr Ser Ser Ser 
            740 


<210>  161
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC301 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H105 linker)

<400>  161
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctggtgg aggcggttca     1500

ggcggaggtg gctccggcgg tggcggatcg caggtccagc tggtggagtc tgggggcgga     1560

gtggtgcagc ctgggcggtc actgaggctg tcctgcaagg cttctggcta cacctttact     1620

agatctacga tgcactgggt aaggcaggcc cctggacaag gtctggaatg gattggatac     1680

attaatccta gcagtgctta tactaattac aatcagaaat tcaaggacag gttcacaatc     1740

agcgcagaca aatccaagag cacagccttc ctgcagatgg acagcctgag gcccgaggac     1800

accggcgtct atttctgtgc acggccccaa gtccactatg attacaacgg gtttccttac     1860

tggggccaag ggactcccgt cactgtctct agcggtggcg gagggtctgg gggtggcgga     1920

tccggaggtg gtggctctgc acaagacatc cagatgaccc agtctccaag cagcctgtct     1980

gcaagcgtgg gggacagggt caccatgacc tgcagtgcca gctcaagtgt aagttacatg     2040

aactggtacc agcagaagcc gggcaaggcc cccaaaagat ggatttatga ctcatccaaa     2100

ctggcttctg gagtccctgc tcgcttcagt ggcagtgggt ctgggaccga ctataccctc     2160

acaatcagca gcctgcagcc cgaagatttc gccacttatt actgccagca gtggagtcgt     2220

aacccaccca cgttcggagg ggggaccaag ctacaaatta catcctccag ctaa           2274


<210>  162
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC301 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H105 linker)

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
                485                 490                 495     


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    530                 535                 540                 


Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
545                 550                 555                 560 


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
                565                 570                 575     


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His 
            580                 585                 590         


Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
625                 630                 635                 640 


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
                645                 650                 655     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            660                 665                 670         


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
705                 710                 715                 720 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
                725                 730                 735     


Ser 
    


<210>  163
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized TSC302 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H106 linker)

<400>  163
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctcagg tccagctggt ggagtctggg     1560

ggcggagtgg tgcagcctgg gcggtcactg aggctgtcct gcaaggcttc tggctacacc     1620

tttactagat ctacgatgca ctgggtaagg caggcccctg gacaaggtct ggaatggatt     1680

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacaggttc     1740

acaatcagcg cagacaaatc caagagcaca gccttcctgc agatggacag cctgaggccc     1800

gaggacaccg gcgtctattt ctgtgcacgg ccccaagtcc actatgatta caacgggttt     1860

ccttactggg gccaagggac tcccgtcact gtctctagcg gtggcggagg gtctgggggt     1920

ggcggatccg gaggtggtgg ctctgcacaa gacatccaga tgacccagtc tccaagcagc     1980

ctgtctgcaa gcgtggggga cagggtcacc atgacctgca gtgccagctc aagtgtaagt     2040

tacatgaact ggtaccagca gaagccgggc aaggccccca aaagatggat ttatgactca     2100

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gaccgactat     2160

accctcacaa tcagcagcct gcagcccgaa gatttcgcca cttattactg ccagcagtgg     2220

agtcgtaacc cacccacgtt cggagggggg accaagctac aaattacatc ctccagctaa     2280


<210>  164
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized TSC302 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H106 linker)

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Gln Val Gln Leu 
                485                 490                 495     


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
            500                 505                 510         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        515                 520                 525             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    530                 535                 540                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
545                 550                 555                 560 


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
                565                 570                 575     


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
            580                 585                 590         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
        595                 600                 605             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
625                 630                 635                 640 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
                645                 650                 655     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            660                 665                 670         


Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro 
        675                 680                 685             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
    690                 695                 700                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
705                 710                 715                 720 


Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
                725                 730                 735     


Ser Ser Ser 
            


<210>  165
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  n=5

<400>  165

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  



