                         SEQUENCE LISTING

<110>  University of Massachusetts
       Flotte, Terence
       Mueller, Christian
 
<120>  RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 
       ANTI-TRYPSIN DEFICIENCIES

<130>  U0120.70052WO00

<140>  Not yet assigned
<141>  2012-04-20


<150>  US 61/477,671
<151>  2011-04-21

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  2
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  3
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Lys Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  4
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Lys Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  5
<211>  1257
<212>  RNA
<213>  Homo sapiens

<400>  5
augccgucuu cugucucgug gggcauccuc cugcuggcag gccugugcug ccuggucccu       60

gucucccugg cugaggaucc ccagggagau gcugcccaga agacagauac aucccaccau      120

gaucaggauc acccaaccuu caacaagauc acccccaacc uggcugaguu cgccuucagc      180

cuauaccgcc agcuggcaca ccaguccaac agcaccaaua ucuucuucuc cccagugagc      240

aucgcuacag ccuuugcaau gcucucccug gggaccaagg cugacacuca cgaugaaauc      300

cuggagggcc ugaauuucaa ccucacggag auuccggagg cucagaucca ugaaggcuuc      360

caggaacucc uccguacccu caaccagcca gacagccagc uccagcugac caccggcaau      420

ggccuguucc ucagcgaggg ccugaagcua guggauaagu uuuuggagga uguuaaaaag      480

uuguaccacu cagaagccuu cacugucaac uucggggaca ccgaagaggc caagaaacag      540

aucaacgauu acguggagaa ggguacucaa gggaaaauug uggauuuggu caaggagcuu      600

gacagagaca caguuuuugc ucuggugaau uacaucuucu uuaaaggcaa augggagaga      660

cccuuugaag ucaaggacac cgaggaagag gacuuccacg uggaccaggu gaccaccgug      720

aaggugccua ugaugaagcg uuuaggcaug uuuaacaucc agcacuguaa gaagcugucc      780

agcugggugc ugcugaugaa auaccugggc aaugccaccg ccaucuucuu ccugccugau      840

gaggggaaac uacagcaccu ggaaaaugaa cucacccacg auaucaucac caaguuccug      900

gaaaaugaag acagaagguc ugccagcuua cauuuaccca aacuguccau uacuggaacc      960

uaugaucuga agagcguccu gggucaacug ggcaucacua aggucuucag caauggggcu     1020

gaccucuccg gggucacaga ggaggcaccc cugaagcucu ccaaggccgu gcauaaggcu     1080

gugcugacca ucgacgagaa agggacugaa gcugcugggg ccauguuuuu agaggccaua     1140

cccaugucua ucccccccga ggucaaguuc aacaaacccu uugucuucuu aaugauugaa     1200

caaaauacca agucuccccu cuucauggga aaagugguga aucccaccca aaaauaa        1257


<210>  6
<211>  3220
<212>  RNA
<213>  Homo sapiens

<400>  6
acaaugacuc cuuucgguaa gugcagugga agcuguacac ugcccaggca aagcguccgg       60

gcagcguagg cgggcgacuc agaucccagc caguggacuu agccccuguu ugcuccuccg      120

auaacugggg ugaccuuggu uaauauucac cagcagccuc ccccguugcc ccucuggauc      180

cacugcuuaa auacggacga ggacagggcc cugucuccuc agcuucaggc accaccacug      240

accugggaca gugaaucgac aaugccgucu ucugucucgu ggggcauccu ccugcuggca      300

ggccugugcu gccugguccc ugucucccug gcugaggauc cccagggaga ugcugcccag      360

aagacagaua caucccacca ugaucaggau cacccaaccu ucaacaagau cacccccaac      420

cuggcugagu ucgccuucag ccuauaccgc cagcuggcac accaguccaa cagcaccaau      480

aucuucuucu ccccagugag caucgcuaca gccuuugcaa ugcucucccu ggggaccaag      540

gcugacacuc acgaugaaau ccuggagggc cugaauuuca accucacgga gauuccggag      600

gcucagaucc augaaggcuu ccaggaacuc cuccguaccc ucaaccagcc agacagccag      660

cuccagcuga ccaccggcaa uggccuguuc cucagcgagg gccugaagcu aguggauaag      720

uuuuuggagg auguuaaaaa guuguaccac ucagaagccu ucacugucaa cuucggggac      780

accgaagagg ccaagaaaca gaucaacgau uacguggaga aggguacuca agggaaaauu      840

guggauuugg ucaaggagcu ugacagagac acaguuuuug cucuggugaa uuacaucuuc      900

uuuaaaggca aaugggagag acccuuugaa gucaaggaca ccgaggaaga ggacuuccac      960

guggaccagg ugaccaccgu gaaggugccu augaugaagc guuuaggcau guuuaacauc     1020

cagcacugua agaagcuguc cagcugggug cugcugauga aauaccuggg caaugccacc     1080

gccaucuucu uccugccuga ugaggggaaa cuacagcacc uggaaaauga acucacccac     1140

gauaucauca ccaaguuccu ggaaaaugaa gacagaaggu cugccagcuu acauuuaccc     1200

aaacugucca uuacuggaac cuaugaucug aagagcgucc ugggucaacu gggcaucacu     1260

aaggucuuca gcaauggggc ugaccucucc ggggucacag aggaggcacc ccugaagcuc     1320

uccaaggccg ugcauaaggc ugugcugacc aucgacgaga aagggacuga agcugcuggg     1380

gccauguuuu uagaggccau acccaugucu aucccccccg aggucaaguu caacaaaccc     1440

uuugucuucu uaaugauuga acaaaauacc aagucucccc ucuucauggg aaaaguggug     1500

aaucccaccc aaaaauaacu gccucucgcu ccucaacccc uccccuccau cccuggcccc     1560

cucccuggau gacauuaaag aaggguugag cuggucccug ccugcaugug acuguaaauc     1620

ccucccaugu uuucucugag ucucccuuug ccugcugagg cuguaugugg gcuccaggua     1680

acagugcugu cuucgggccc ccugaacugu guucauggag caucuggcug gguaggcaca     1740

ugcugggcuu gaauccaggg gggacugaau ccucagcuua cggaccuggg cccaucuguu     1800

ucuggagggc uccagucuuc cuuguccugu cuuggagucc ccaagaagga aucacagggg     1860

aggaaccaga uaccagccau gaccccaggc uccaccaagc aucuucaugu cccccugcuc     1920

aucccccacu cccccccacc cagaguugcu cauccugcca gggcuggcug ugcccacccc     1980

aaggcugccc uccugggggc cccagaacug ccugaucgug ccguggccca guuuuguggc     2040

aucugcagca acacaagaga gaggacaaug uccuccucuu gacccgcugu caccuaacca     2100

gacucgggcc cugcaccucu caggcacuuc uggaaaauga cugaggcaga uucuuccuga     2160

agcccauucu ccauggggca acaaggacac cuauucuguc cuuguccuuc caucgcugcc     2220

ccagaaagcc ucacauaucu ccguuuagaa ucaggucccu ucuccccaga ugaagaggag     2280

ggucucugcu uuguuuucuc uaucuccucc ucagacuuga ccaggcccag caggccccag     2340

aagaccauua cccuauaucc cuucuccucc cuagucacau ggccauaggc cugcugaugg     2400

cucaggaagg ccauugcaag gacuccucag cuaugggaga ggaagcacau cacccauuga     2460

cccccgcaac cccucccuuu ccuccucuga gucccgacug gggccacaug cagccugacu     2520

ucuuugugcc uguugcuguc ccugcagucu ucagagggcc accgcagcuc cagugccacg     2580

gcaggaggcu guuccugaau agccccugug guaagggcca ggagaguccu uccauccucc     2640

aaggcccugc uaaaggacac agcagccagg aaguccccug ggccccuagc ugaaggacag     2700

ccugcucccu ccgucucuac caggaauggc cuuguccuau ggaaggcacu gccccauccc     2760

aaacuaaucu aggaaucacu gucuaaccac ucacugucau gaauguguac uuaaaggaug     2820

agguugaguc auaccaaaua gugauuucga uaguucaaaa uggugaaauu agcaauucua     2880

caugauucag ucuaaucaau ggauaccgac uguuucccac acaagucucc uguucucuua     2940

agcuuacuca cugacagccu uucacucucc acaaauacau uaaagauaug gccaucacca     3000

agcccccuag gaugacacca gaccugagag ucugaagacc uggauccaag uucugacuuu     3060

ucccccugac agcuguguga ccuucgugaa gucgccaaac cucucugagc cccagucauu     3120

gcuaguaaga ccugccuuug aguugguaug auguucaagu uagauaacaa aauguuuaua     3180

cccauuagaa cagagaauaa auagaacuac auuucuugca                           3220


<210>  7
<211>  3513
<212>  RNA
<213>  Homo sapiens

<400>  7
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagggcg      240

gcaguaaguc uucagcauca ggcauuuugg ggugacucag uaaaugguag aucuugcuac      300

caguggaaca gccacuaagg auucugcagu gagagcagag ggccagcuaa gugguacucu      360

cccagagacu gucugacuca cgccaccccc uccaccuugg acacaggacg cugugguuuc      420

ugagccaggu acaaugacuc cuuucgcagc cucccccguu gccccucugg auccacugcu      480

uaaauacgga cgaggacagg gcccugucuc cucagcuuca ggcaccacca cugaccuggg      540

acagugaauc gacaaugccg ucuucugucu cguggggcau ccuccugcug gcaggccugu      600

gcugccuggu cccugucucc cuggcugagg auccccaggg agaugcugcc cagaagacag      660

auacauccca ccaugaucag gaucacccaa ccuucaacaa gaucaccccc aaccuggcug      720

aguucgccuu cagccuauac cgccagcugg cacaccaguc caacagcacc aauaucuucu      780

ucuccccagu gagcaucgcu acagccuuug caaugcucuc ccuggggacc aaggcugaca      840

cucacgauga aauccuggag ggccugaauu ucaaccucac ggagauuccg gaggcucaga      900

uccaugaagg cuuccaggaa cuccuccgua cccucaacca gccagacagc cagcuccagc      960

ugaccaccgg caauggccug uuccucagcg agggccugaa gcuaguggau aaguuuuugg     1020

aggauguuaa aaaguuguac cacucagaag ccuucacugu caacuucggg gacaccgaag     1080

aggccaagaa acagaucaac gauuacgugg agaaggguac ucaagggaaa auuguggauu     1140

uggucaagga gcuugacaga gacacaguuu uugcucuggu gaauuacauc uucuuuaaag     1200

gcaaauggga gagacccuuu gaagucaagg acaccgagga agaggacuuc cacguggacc     1260

aggugaccac cgugaaggug ccuaugauga agcguuuagg cauguuuaac auccagcacu     1320

guaagaagcu guccagcugg gugcugcuga ugaaauaccu gggcaaugcc accgccaucu     1380

ucuuccugcc ugaugagggg aaacuacagc accuggaaaa ugaacucacc cacgauauca     1440

ucaccaaguu ccuggaaaau gaagacagaa ggucugccag cuuacauuua cccaaacugu     1500

ccauuacugg aaccuaugau cugaagagcg uccuggguca acugggcauc acuaaggucu     1560

ucagcaaugg ggcugaccuc uccgggguca cagaggaggc accccugaag cucuccaagg     1620

ccgugcauaa ggcugugcug accaucgacg agaaagggac ugaagcugcu ggggccaugu     1680

uuuuagaggc cauacccaug ucuauccccc ccgaggucaa guucaacaaa cccuuugucu     1740

ucuuaaugau ugaacaaaau accaagucuc cccucuucau gggaaaagug gugaauccca     1800

cccaaaaaua acugccucuc gcuccucaac cccuccccuc caucccuggc ccccucccug     1860

gaugacauua aagaaggguu gagcuggucc cugccugcau gugacuguaa aucccuccca     1920

uguuuucucu gagucucccu uugccugcug aggcuguaug ugggcuccag guaacagugc     1980

ugucuucggg cccccugaac uguguucaug gagcaucugg cuggguaggc acaugcuggg     2040

cuugaaucca ggggggacug aauccucagc uuacggaccu gggcccaucu guuucuggag     2100

ggcuccaguc uuccuugucc ugucuuggag uccccaagaa ggaaucacag gggaggaacc     2160

agauaccagc caugacccca ggcuccacca agcaucuuca ugucccccug cucauccccc     2220

acuccccccc acccagaguu gcucauccug ccagggcugg cugugcccac cccaaggcug     2280

cccuccuggg ggccccagaa cugccugauc gugccguggc ccaguuuugu ggcaucugca     2340

gcaacacaag agagaggaca auguccuccu cuugacccgc ugucaccuaa ccagacucgg     2400

gcccugcacc ucucaggcac uucuggaaaa ugacugaggc agauucuucc ugaagcccau     2460

ucuccauggg gcaacaagga caccuauucu guccuugucc uuccaucgcu gccccagaaa     2520

gccucacaua ucuccguuua gaaucagguc ccuucucccc agaugaagag gagggucucu     2580

gcuuuguuuu cucuaucucc uccucagacu ugaccaggcc cagcaggccc cagaagacca     2640

uuacccuaua ucccuucucc ucccuaguca cauggccaua ggccugcuga uggcucagga     2700

aggccauugc aaggacuccu cagcuauggg agaggaagca caucacccau ugacccccgc     2760

aaccccuccc uuuccuccuc ugagucccga cuggggccac augcagccug acuucuuugu     2820

gccuguugcu gucccugcag ucuucagagg gccaccgcag cuccagugcc acggcaggag     2880

gcuguuccug aauagccccu gugguaaggg ccaggagagu ccuuccaucc uccaaggccc     2940

ugcuaaagga cacagcagcc aggaaguccc cugggccccu agcugaagga cagccugcuc     3000

ccuccgucuc uaccaggaau ggccuugucc uauggaaggc acugccccau cccaaacuaa     3060

ucuaggaauc acugucuaac cacucacugu caugaaugug uacuuaaagg augagguuga     3120

gucauaccaa auagugauuu cgauaguuca aaauggugaa auuagcaauu cuacaugauu     3180

cagucuaauc aauggauacc gacuguuucc cacacaaguc uccuguucuc uuaagcuuac     3240

ucacugacag ccuuucacuc uccacaaaua cauuaaagau auggccauca ccaagccccc     3300

uaggaugaca ccagaccuga gagucugaag accuggaucc aaguucugac uuuucccccu     3360

gacagcugug ugaccuucgu gaagucgcca aaccucucug agccccaguc auugcuagua     3420

agaccugccu uugaguuggu augauguuca aguuagauaa caaaauguuu auacccauua     3480

gaacagagaa uaaauagaac uacauuucuu gca                                  3513


<210>  8
<211>  3236
<212>  RNA
<213>  Homo sapiens

<400>  8
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaaggugg      240

gacauugcug cugcugcuca cucaguucca caggacaaug ccgucuucug ucucgugggg      300

cauccuccug cuggcaggcc ugugcugccu ggucccuguc ucccuggcug aggaucccca      360

gggagaugcu gcccagaaga cagauacauc ccaccaugau caggaucacc caaccuucaa      420

caagaucacc cccaaccugg cugaguucgc cuucagccua uaccgccagc uggcacacca      480

guccaacagc accaauaucu ucuucucccc agugagcauc gcuacagccu uugcaaugcu      540

cucccugggg accaaggcug acacucacga ugaaauccug gagggccuga auuucaaccu      600

cacggagauu ccggaggcuc agauccauga aggcuuccag gaacuccucc guacccucaa      660

ccagccagac agccagcucc agcugaccac cggcaauggc cuguuccuca gcgagggccu      720

gaagcuagug gauaaguuuu uggaggaugu uaaaaaguug uaccacucag aagccuucac      780

ugucaacuuc ggggacaccg aagaggccaa gaaacagauc aacgauuacg uggagaaggg      840

uacucaaggg aaaauugugg auuuggucaa ggagcuugac agagacacag uuuuugcucu      900

ggugaauuac aucuucuuua aaggcaaaug ggagagaccc uuugaaguca aggacaccga      960

ggaagaggac uuccacgugg accaggugac caccgugaag gugccuauga ugaagcguuu     1020

aggcauguuu aacauccagc acuguaagaa gcuguccagc ugggugcugc ugaugaaaua     1080

ccugggcaau gccaccgcca ucuucuuccu gccugaugag gggaaacuac agcaccugga     1140

aaaugaacuc acccacgaua ucaucaccaa guuccuggaa aaugaagaca gaaggucugc     1200

cagcuuacau uuacccaaac uguccauuac uggaaccuau gaucugaaga gcguccuggg     1260

ucaacugggc aucacuaagg ucuucagcaa uggggcugac cucuccgggg ucacagagga     1320

ggcaccccug aagcucucca aggccgugca uaaggcugug cugaccaucg acgagaaagg     1380

gacugaagcu gcuggggcca uguuuuuaga ggccauaccc augucuaucc cccccgaggu     1440

caaguucaac aaacccuuug ucuucuuaau gauugaacaa aauaccaagu cuccccucuu     1500

caugggaaaa guggugaauc ccacccaaaa auaacugccu cucgcuccuc aaccccuccc     1560

cuccaucccu ggcccccucc cuggaugaca uuaaagaagg guugagcugg ucccugccug     1620

caugugacug uaaaucccuc ccauguuuuc ucugagucuc ccuuugccug cugaggcugu     1680

augugggcuc cagguaacag ugcugucuuc gggcccccug aacuguguuc auggagcauc     1740

uggcugggua ggcacaugcu gggcuugaau ccagggggga cugaauccuc agcuuacgga     1800

ccugggccca ucuguuucug gagggcucca gucuuccuug uccugucuug gaguccccaa     1860

gaaggaauca caggggagga accagauacc agccaugacc ccaggcucca ccaagcaucu     1920

ucaugucccc cugcucaucc cccacucccc cccacccaga guugcucauc cugccagggc     1980

uggcugugcc caccccaagg cugcccuccu gggggcccca gaacugccug aucgugccgu     2040

ggcccaguuu uguggcaucu gcagcaacac aagagagagg acaauguccu ccucuugacc     2100

cgcugucacc uaaccagacu cgggcccugc accucucagg cacuucugga aaaugacuga     2160

ggcagauucu uccugaagcc cauucuccau ggggcaacaa ggacaccuau ucuguccuug     2220

uccuuccauc gcugccccag aaagccucac auaucuccgu uuagaaucag gucccuucuc     2280

cccagaugaa gaggaggguc ucugcuuugu uuucucuauc uccuccucag acuugaccag     2340

gcccagcagg ccccagaaga ccauuacccu auaucccuuc uccucccuag ucacauggcc     2400

auaggccugc ugauggcuca ggaaggccau ugcaaggacu ccucagcuau gggagaggaa     2460

gcacaucacc cauugacccc cgcaaccccu cccuuuccuc cucugagucc cgacuggggc     2520

cacaugcagc cugacuucuu ugugccuguu gcugucccug cagucuucag agggccaccg     2580

cagcuccagu gccacggcag gaggcuguuc cugaauagcc ccugugguaa gggccaggag     2640

aguccuucca uccuccaagg cccugcuaaa ggacacagca gccaggaagu ccccugggcc     2700

ccuagcugaa ggacagccug cucccuccgu cucuaccagg aauggccuug uccuauggaa     2760

ggcacugccc caucccaaac uaaucuagga aucacugucu aaccacucac ugucaugaau     2820

guguacuuaa aggaugaggu ugagucauac caaauaguga uuucgauagu ucaaaauggu     2880

gaaauuagca auucuacaug auucagucua aucaauggau accgacuguu ucccacacaa     2940

gucuccuguu cucuuaagcu uacucacuga cagccuuuca cucuccacaa auacauuaaa     3000

gauauggcca ucaccaagcc cccuaggaug acaccagacc ugagagucug aagaccugga     3060

uccaaguucu gacuuuuccc ccugacagcu gugugaccuu cgugaagucg ccaaaccucu     3120

cugagcccca gucauugcua guaagaccug ccuuugaguu gguaugaugu ucaaguuaga     3180

uaacaaaaug uuuauaccca uuagaacaga gaauaaauag aacuacauuu cuugca         3236


<210>  9
<211>  3532
<212>  RNA
<213>  Homo sapiens

<400>  9
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaaggugg      240

gacauugcug cugcugcuca cucaguucca cagggcggca guaagucuuc agcaucaggc      300

auuuuggggu gacucaguaa augguagauc uugcuaccag uggaacagcc acuaaggauu      360

cugcagugag agcagagggc cagcuaagug guacucuccc agagacuguc ugacucacgc      420

cacccccucc accuuggaca caggacgcug ugguuucuga gccagcagcc ucccccguug      480

ccccucugga uccacugcuu aaauacggac gaggacaggg cccugucucc ucagcuucag      540

gcaccaccac ugaccuggga cagugaaucg acaaugccgu cuucugucuc guggggcauc      600

cuccugcugg caggccugug cugccugguc ccugucuccc uggcugagga uccccaggga      660

gaugcugccc agaagacaga uacaucccac caugaucagg aucacccaac cuucaacaag      720

aucaccccca accuggcuga guucgccuuc agccuauacc gccagcuggc acaccagucc      780

aacagcacca auaucuucuu cuccccagug agcaucgcua cagccuuugc aaugcucucc      840

cuggggacca aggcugacac ucacgaugaa auccuggagg gccugaauuu caaccucacg      900

gagauuccgg aggcucagau ccaugaaggc uuccaggaac uccuccguac ccucaaccag      960

ccagacagcc agcuccagcu gaccaccggc aauggccugu uccucagcga gggccugaag     1020

cuaguggaua aguuuuugga ggauguuaaa aaguuguacc acucagaagc cuucacuguc     1080

aacuucgggg acaccgaaga ggccaagaaa cagaucaacg auuacgugga gaaggguacu     1140

caagggaaaa uuguggauuu ggucaaggag cuugacagag acacaguuuu ugcucuggug     1200

aauuacaucu ucuuuaaagg caaaugggag agacccuuug aagucaagga caccgaggaa     1260

gaggacuucc acguggacca ggugaccacc gugaaggugc cuaugaugaa gcguuuaggc     1320

auguuuaaca uccagcacug uaagaagcug uccagcuggg ugcugcugau gaaauaccug     1380

ggcaaugcca ccgccaucuu cuuccugccu gaugagggga aacuacagca ccuggaaaau     1440

gaacucaccc acgauaucau caccaaguuc cuggaaaaug aagacagaag gucugccagc     1500

uuacauuuac ccaaacuguc cauuacugga accuaugauc ugaagagcgu ccugggucaa     1560

cugggcauca cuaaggucuu cagcaauggg gcugaccucu ccggggucac agaggaggca     1620

ccccugaagc ucuccaaggc cgugcauaag gcugugcuga ccaucgacga gaaagggacu     1680

gaagcugcug gggccauguu uuuagaggcc auacccaugu cuaucccccc cgaggucaag     1740

uucaacaaac ccuuugucuu cuuaaugauu gaacaaaaua ccaagucucc ccucuucaug     1800

ggaaaagugg ugaaucccac ccaaaaauaa cugccucucg cuccucaacc ccuccccucc     1860

aucccuggcc cccucccugg augacauuaa agaaggguug agcugguccc ugccugcaug     1920

ugacuguaaa ucccucccau guuuucucug agucucccuu ugccugcuga ggcuguaugu     1980

gggcuccagg uaacagugcu gucuucgggc ccccugaacu guguucaugg agcaucuggc     2040

uggguaggca caugcugggc uugaauccag gggggacuga auccucagcu uacggaccug     2100

ggcccaucug uuucuggagg gcuccagucu uccuuguccu gucuuggagu ccccaagaag     2160

gaaucacagg ggaggaacca gauaccagcc augaccccag gcuccaccaa gcaucuucau     2220

gucccccugc ucauccccca cuccccccca cccagaguug cucauccugc cagggcuggc     2280

ugugcccacc ccaaggcugc ccuccugggg gccccagaac ugccugaucg ugccguggcc     2340

caguuuugug gcaucugcag caacacaaga gagaggacaa uguccuccuc uugacccgcu     2400

gucaccuaac cagacucggg cccugcaccu cucaggcacu ucuggaaaau gacugaggca     2460

gauucuuccu gaagcccauu cuccaugggg caacaaggac accuauucug uccuuguccu     2520

uccaucgcug ccccagaaag ccucacauau cuccguuuag aaucaggucc cuucucccca     2580

gaugaagagg agggucucug cuuuguuuuc ucuaucuccu ccucagacuu gaccaggccc     2640

agcaggcccc agaagaccau uacccuauau cccuucuccu cccuagucac auggccauag     2700

gccugcugau ggcucaggaa ggccauugca aggacuccuc agcuauggga gaggaagcac     2760

aucacccauu gacccccgca accccucccu uuccuccucu gagucccgac uggggccaca     2820

ugcagccuga cuucuuugug ccuguugcug ucccugcagu cuucagaggg ccaccgcagc     2880

uccagugcca cggcaggagg cuguuccuga auagccccug ugguaagggc caggagaguc     2940

cuuccauccu ccaaggcccu gcuaaaggac acagcagcca ggaagucccc ugggccccua     3000

gcugaaggac agccugcucc cuccgucucu accaggaaug gccuuguccu auggaaggca     3060

cugccccauc ccaaacuaau cuaggaauca cugucuaacc acucacuguc augaaugugu     3120

acuuaaagga ugagguugag ucauaccaaa uagugauuuc gauaguucaa aauggugaaa     3180

uuagcaauuc uacaugauuc agucuaauca auggauaccg acuguuuccc acacaagucu     3240

ccuguucucu uaagcuuacu cacugacagc cuuucacucu ccacaaauac auuaaagaua     3300

uggccaucac caagcccccu aggaugacac cagaccugag agucugaaga ccuggaucca     3360

aguucugacu uuucccccug acagcugugu gaccuucgug aagucgccaa accucucuga     3420

gccccaguca uugcuaguaa gaccugccuu ugaguuggua ugauguucaa guuagauaac     3480

aaaauguuua uacccauuag aacagagaau aaauagaacu acauuucuug ca             3532


<210>  10
<211>  3340
<212>  RNA
<213>  Homo sapiens

<400>  10
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaaggugg      240

gacauugcug cugcugcuca cucaguucca cagcagccuc ccccguugcc ccucuggauc      300

cacugcuuaa auacggacga ggacagggcc cugucuccuc agcuucaggc accaccacug      360

accugggaca gugaaucgac aaugccgucu ucugucucgu ggggcauccu ccugcuggca      420

ggccugugcu gccugguccc ugucucccug gcugaggauc cccagggaga ugcugcccag      480

aagacagaua caucccacca ugaucaggau cacccaaccu ucaacaagau cacccccaac      540

cuggcugagu ucgccuucag ccuauaccgc cagcuggcac accaguccaa cagcaccaau      600

aucuucuucu ccccagugag caucgcuaca gccuuugcaa ugcucucccu ggggaccaag      660

gcugacacuc acgaugaaau ccuggagggc cugaauuuca accucacgga gauuccggag      720

gcucagaucc augaaggcuu ccaggaacuc cuccguaccc ucaaccagcc agacagccag      780

cuccagcuga ccaccggcaa uggccuguuc cucagcgagg gccugaagcu aguggauaag      840

uuuuuggagg auguuaaaaa guuguaccac ucagaagccu ucacugucaa cuucggggac      900

accgaagagg ccaagaaaca gaucaacgau uacguggaga aggguacuca agggaaaauu      960

guggauuugg ucaaggagcu ugacagagac acaguuuuug cucuggugaa uuacaucuuc     1020

uuuaaaggca aaugggagag acccuuugaa gucaaggaca ccgaggaaga ggacuuccac     1080

guggaccagg ugaccaccgu gaaggugccu augaugaagc guuuaggcau guuuaacauc     1140

cagcacugua agaagcuguc cagcugggug cugcugauga aauaccuggg caaugccacc     1200

gccaucuucu uccugccuga ugaggggaaa cuacagcacc uggaaaauga acucacccac     1260

gauaucauca ccaaguuccu ggaaaaugaa gacagaaggu cugccagcuu acauuuaccc     1320

aaacugucca uuacuggaac cuaugaucug aagagcgucc ugggucaacu gggcaucacu     1380

aaggucuuca gcaauggggc ugaccucucc ggggucacag aggaggcacc ccugaagcuc     1440

uccaaggccg ugcauaaggc ugugcugacc aucgacgaga aagggacuga agcugcuggg     1500

gccauguuuu uagaggccau acccaugucu aucccccccg aggucaaguu caacaaaccc     1560

uuugucuucu uaaugauuga acaaaauacc aagucucccc ucuucauggg aaaaguggug     1620

aaucccaccc aaaaauaacu gccucucgcu ccucaacccc uccccuccau cccuggcccc     1680

cucccuggau gacauuaaag aaggguugag cuggucccug ccugcaugug acuguaaauc     1740

ccucccaugu uuucucugag ucucccuuug ccugcugagg cuguaugugg gcuccaggua     1800

acagugcugu cuucgggccc ccugaacugu guucauggag caucuggcug gguaggcaca     1860

ugcugggcuu gaauccaggg gggacugaau ccucagcuua cggaccuggg cccaucuguu     1920

ucuggagggc uccagucuuc cuuguccugu cuuggagucc ccaagaagga aucacagggg     1980

aggaaccaga uaccagccau gaccccaggc uccaccaagc aucuucaugu cccccugcuc     2040

aucccccacu cccccccacc cagaguugcu cauccugcca gggcuggcug ugcccacccc     2100

aaggcugccc uccugggggc cccagaacug ccugaucgug ccguggccca guuuuguggc     2160

aucugcagca acacaagaga gaggacaaug uccuccucuu gacccgcugu caccuaacca     2220

gacucgggcc cugcaccucu caggcacuuc uggaaaauga cugaggcaga uucuuccuga     2280

agcccauucu ccauggggca acaaggacac cuauucuguc cuuguccuuc caucgcugcc     2340

ccagaaagcc ucacauaucu ccguuuagaa ucaggucccu ucuccccaga ugaagaggag     2400

ggucucugcu uuguuuucuc uaucuccucc ucagacuuga ccaggcccag caggccccag     2460

aagaccauua cccuauaucc cuucuccucc cuagucacau ggccauaggc cugcugaugg     2520

cucaggaagg ccauugcaag gacuccucag cuaugggaga ggaagcacau cacccauuga     2580

cccccgcaac cccucccuuu ccuccucuga gucccgacug gggccacaug cagccugacu     2640

ucuuugugcc uguugcuguc ccugcagucu ucagagggcc accgcagcuc cagugccacg     2700

gcaggaggcu guuccugaau agccccugug guaagggcca ggagaguccu uccauccucc     2760

aaggcccugc uaaaggacac agcagccagg aaguccccug ggccccuagc ugaaggacag     2820

ccugcucccu ccgucucuac caggaauggc cuuguccuau ggaaggcacu gccccauccc     2880

aaacuaaucu aggaaucacu gucuaaccac ucacugucau gaauguguac uuaaaggaug     2940

agguugaguc auaccaaaua gugauuucga uaguucaaaa uggugaaauu agcaauucua     3000

caugauucag ucuaaucaau ggauaccgac uguuucccac acaagucucc uguucucuua     3060

agcuuacuca cugacagccu uucacucucc acaaauacau uaaagauaug gccaucacca     3120

agcccccuag gaugacacca gaccugagag ucugaagacc uggauccaag uucugacuuu     3180

ucccccugac agcuguguga ccuucgugaa gucgccaaac cucucugagc cccagucauu     3240

gcuaguaaga ccugccuuug aguugguaug auguucaagu uagauaacaa aauguuuaua     3300

cccauuagaa cagagaauaa auagaacuac auuucuugca                           3340


<210>  11
<211>  3495
<212>  RNA
<213>  Homo sapiens

<400>  11
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagggcg      240

gcaguaaguc uucagcauca ggcauuuugg ggugacucag uaaaugguag aucuugcuac      300

caguggaaca gccacuaagg auucugcagu gagagcagag ggccagcuaa gugguacucu      360

cccagagacu gucugacuca cgccaccccc uccaccuugg acacaggacg cugugguuuc      420

ugagccagca gccucccccg uugccccucu ggauccacug cuuaaauacg gacgaggaca      480

gggcccuguc uccucagcuu caggcaccac cacugaccug ggacagugaa ucgacaaugc      540

cgucuucugu cucguggggc auccuccugc uggcaggccu gugcugccug gucccugucu      600

cccuggcuga ggauccccag ggagaugcug cccagaagac agauacaucc caccaugauc      660

aggaucaccc aaccuucaac aagaucaccc ccaaccuggc ugaguucgcc uucagccuau      720

accgccagcu ggcacaccag uccaacagca ccaauaucuu cuucucccca gugagcaucg      780

cuacagccuu ugcaaugcuc ucccugggga ccaaggcuga cacucacgau gaaauccugg      840

agggccugaa uuucaaccuc acggagauuc cggaggcuca gauccaugaa ggcuuccagg      900

aacuccuccg uacccucaac cagccagaca gccagcucca gcugaccacc ggcaauggcc      960

uguuccucag cgagggccug aagcuagugg auaaguuuuu ggaggauguu aaaaaguugu     1020

accacucaga agccuucacu gucaacuucg gggacaccga agaggccaag aaacagauca     1080

acgauuacgu ggagaagggu acucaaggga aaauugugga uuuggucaag gagcuugaca     1140

gagacacagu uuuugcucug gugaauuaca ucuucuuuaa aggcaaaugg gagagacccu     1200

uugaagucaa ggacaccgag gaagaggacu uccacgugga ccaggugacc accgugaagg     1260

ugccuaugau gaagcguuua ggcauguuua acauccagca cuguaagaag cuguccagcu     1320

gggugcugcu gaugaaauac cugggcaaug ccaccgccau cuucuuccug ccugaugagg     1380

ggaaacuaca gcaccuggaa aaugaacuca cccacgauau caucaccaag uuccuggaaa     1440

augaagacag aaggucugcc agcuuacauu uacccaaacu guccauuacu ggaaccuaug     1500

aucugaagag cguccugggu caacugggca ucacuaaggu cuucagcaau ggggcugacc     1560

ucuccggggu cacagaggag gcaccccuga agcucuccaa ggccgugcau aaggcugugc     1620

ugaccaucga cgagaaaggg acugaagcug cuggggccau guuuuuagag gccauaccca     1680

ugucuauccc ccccgagguc aaguucaaca aacccuuugu cuucuuaaug auugaacaaa     1740

auaccaaguc uccccucuuc augggaaaag uggugaaucc cacccaaaaa uaacugccuc     1800

ucgcuccuca accccucccc uccaucccug gcccccuccc uggaugacau uaaagaaggg     1860

uugagcuggu cccugccugc augugacugu aaaucccucc cauguuuucu cugagucucc     1920

cuuugccugc ugaggcugua ugugggcucc agguaacagu gcugucuucg ggcccccuga     1980

acuguguuca uggagcaucu ggcuggguag gcacaugcug ggcuugaauc caggggggac     2040

ugaauccuca gcuuacggac cugggcccau cuguuucugg agggcuccag ucuuccuugu     2100

ccugucuugg aguccccaag aaggaaucac aggggaggaa ccagauacca gccaugaccc     2160

caggcuccac caagcaucuu cauguccccc ugcucauccc ccacuccccc ccacccagag     2220

uugcucaucc ugccagggcu ggcugugccc accccaaggc ugcccuccug ggggccccag     2280

aacugccuga ucgugccgug gcccaguuuu guggcaucug cagcaacaca agagagagga     2340

caauguccuc cucuugaccc gcugucaccu aaccagacuc gggcccugca ccucucaggc     2400

acuucuggaa aaugacugag gcagauucuu ccugaagccc auucuccaug gggcaacaag     2460

gacaccuauu cuguccuugu ccuuccaucg cugccccaga aagccucaca uaucuccguu     2520

uagaaucagg ucccuucucc ccagaugaag aggagggucu cugcuuuguu uucucuaucu     2580

ccuccucaga cuugaccagg cccagcaggc cccagaagac cauuacccua uaucccuucu     2640

ccucccuagu cacauggcca uaggccugcu gauggcucag gaaggccauu gcaaggacuc     2700

cucagcuaug ggagaggaag cacaucaccc auugaccccc gcaaccccuc ccuuuccucc     2760

ucugaguccc gacuggggcc acaugcagcc ugacuucuuu gugccuguug cugucccugc     2820

agucuucaga gggccaccgc agcuccagug ccacggcagg aggcuguucc ugaauagccc     2880

cugugguaag ggccaggaga guccuuccau ccuccaaggc ccugcuaaag gacacagcag     2940

ccaggaaguc cccugggccc cuagcugaag gacagccugc ucccuccguc ucuaccagga     3000

auggccuugu ccuauggaag gcacugcccc aucccaaacu aaucuaggaa ucacugucua     3060

accacucacu gucaugaaug uguacuuaaa ggaugagguu gagucauacc aaauagugau     3120

uucgauaguu caaaauggug aaauuagcaa uucuacauga uucagucuaa ucaauggaua     3180

ccgacuguuu cccacacaag ucuccuguuc ucuuaagcuu acucacugac agccuuucac     3240

ucuccacaaa uacauuaaag auauggccau caccaagccc ccuaggauga caccagaccu     3300

gagagucuga agaccuggau ccaaguucug acuuuucccc cugacagcug ugugaccuuc     3360

gugaagucgc caaaccucuc ugagccccag ucauugcuag uaagaccugc cuuugaguug     3420

guaugauguu caaguuagau aacaaaaugu uuauacccau uagaacagag aauaaauaga     3480

acuacauuuc uugca                                                      3495


<210>  12
<211>  3492
<212>  RNA
<213>  Homo sapiens

<400>  12
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagggcg      240

gcaguaaguc uucagcauca ggcauuuugg ggugacucag uaaaugguag aucuugcuac      300

caguggaaca gccacuaagg auucugcagu gagagcagag ggccagcuaa gugguacucu      360

cccagagacu gucugacuca cgccaccccc uccaccuugg acacaggacg cugugguuuc      420

ugagccagcc ucccccguug ccccucugga uccacugcuu aaauacggac gaggacaggg      480

cccugucucc ucagcuucag gcaccaccac ugaccuggga cagugaaucg acaaugccgu      540

cuucugucuc guggggcauc cuccugcugg caggccugug cugccugguc ccugucuccc      600

uggcugagga uccccaggga gaugcugccc agaagacaga uacaucccac caugaucagg      660

aucacccaac cuucaacaag aucaccccca accuggcuga guucgccuuc agccuauacc      720

gccagcuggc acaccagucc aacagcacca auaucuucuu cuccccagug agcaucgcua      780

cagccuuugc aaugcucucc cuggggacca aggcugacac ucacgaugaa auccuggagg      840

gccugaauuu caaccucacg gagauuccgg aggcucagau ccaugaaggc uuccaggaac      900

uccuccguac ccucaaccag ccagacagcc agcuccagcu gaccaccggc aauggccugu      960

uccucagcga gggccugaag cuaguggaua aguuuuugga ggauguuaaa aaguuguacc     1020

acucagaagc cuucacuguc aacuucgggg acaccgaaga ggccaagaaa cagaucaacg     1080

auuacgugga gaaggguacu caagggaaaa uuguggauuu ggucaaggag cuugacagag     1140

acacaguuuu ugcucuggug aauuacaucu ucuuuaaagg caaaugggag agacccuuug     1200

aagucaagga caccgaggaa gaggacuucc acguggacca ggugaccacc gugaaggugc     1260

cuaugaugaa gcguuuaggc auguuuaaca uccagcacug uaagaagcug uccagcuggg     1320

ugcugcugau gaaauaccug ggcaaugcca ccgccaucuu cuuccugccu gaugagggga     1380

aacuacagca ccuggaaaau gaacucaccc acgauaucau caccaaguuc cuggaaaaug     1440

aagacagaag gucugccagc uuacauuuac ccaaacuguc cauuacugga accuaugauc     1500

ugaagagcgu ccugggucaa cugggcauca cuaaggucuu cagcaauggg gcugaccucu     1560

ccggggucac agaggaggca ccccugaagc ucuccaaggc cgugcauaag gcugugcuga     1620

ccaucgacga gaaagggacu gaagcugcug gggccauguu uuuagaggcc auacccaugu     1680

cuaucccccc cgaggucaag uucaacaaac ccuuugucuu cuuaaugauu gaacaaaaua     1740

ccaagucucc ccucuucaug ggaaaagugg ugaaucccac ccaaaaauaa cugccucucg     1800

cuccucaacc ccuccccucc aucccuggcc cccucccugg augacauuaa agaaggguug     1860

agcugguccc ugccugcaug ugacuguaaa ucccucccau guuuucucug agucucccuu     1920

ugccugcuga ggcuguaugu gggcuccagg uaacagugcu gucuucgggc ccccugaacu     1980

guguucaugg agcaucuggc uggguaggca caugcugggc uugaauccag gggggacuga     2040

auccucagcu uacggaccug ggcccaucug uuucuggagg gcuccagucu uccuuguccu     2100

gucuuggagu ccccaagaag gaaucacagg ggaggaacca gauaccagcc augaccccag     2160

gcuccaccaa gcaucuucau gucccccugc ucauccccca cuccccccca cccagaguug     2220

cucauccugc cagggcuggc ugugcccacc ccaaggcugc ccuccugggg gccccagaac     2280

ugccugaucg ugccguggcc caguuuugug gcaucugcag caacacaaga gagaggacaa     2340

uguccuccuc uugacccgcu gucaccuaac cagacucggg cccugcaccu cucaggcacu     2400

ucuggaaaau gacugaggca gauucuuccu gaagcccauu cuccaugggg caacaaggac     2460

accuauucug uccuuguccu uccaucgcug ccccagaaag ccucacauau cuccguuuag     2520

aaucaggucc cuucucccca gaugaagagg agggucucug cuuuguuuuc ucuaucuccu     2580

ccucagacuu gaccaggccc agcaggcccc agaagaccau uacccuauau cccuucuccu     2640

cccuagucac auggccauag gccugcugau ggcucaggaa ggccauugca aggacuccuc     2700

agcuauggga gaggaagcac aucacccauu gacccccgca accccucccu uuccuccucu     2760

gagucccgac uggggccaca ugcagccuga cuucuuugug ccuguugcug ucccugcagu     2820

cuucagaggg ccaccgcagc uccagugcca cggcaggagg cuguuccuga auagccccug     2880

ugguaagggc caggagaguc cuuccauccu ccaaggcccu gcuaaaggac acagcagcca     2940

ggaagucccc ugggccccua gcugaaggac agccugcucc cuccgucucu accaggaaug     3000

gccuuguccu auggaaggca cugccccauc ccaaacuaau cuaggaauca cugucuaacc     3060

acucacuguc augaaugugu acuuaaagga ugagguugag ucauaccaaa uagugauuuc     3120

gauaguucaa aauggugaaa uuagcaauuc uacaugauuc agucuaauca auggauaccg     3180

acuguuuccc acacaagucu ccuguucucu uaagcuuacu cacugacagc cuuucacucu     3240

ccacaaauac auuaaagaua uggccaucac caagcccccu aggaugacac cagaccugag     3300

agucugaaga ccuggaucca aguucugacu uuucccccug acagcugugu gaccuucgug     3360

aagucgccaa accucucuga gccccaguca uugcuaguaa gaccugccuu ugaguuggua     3420

ugauguucaa guuagauaac aaaauguuua uacccauuag aacagagaau aaauagaacu     3480

acauuucuug ca                                                         3492


<210>  13
<211>  3510
<212>  RNA
<213>  Homo sapiens

<400>  13
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagggcg      240

gcaguaaguc uucagcauca ggcauuuugg ggugacucag uaaaugguag aucuugcuac      300

caguggaaca gccacuaagg auucugcagu gagagcagag ggccagcuaa gugguacucu      360

cccagagacu gucugacuca cgccaccccc uccaccuugg acacaggacg cugugguuuc      420

ugagccaggu acaaugacuc cuuucgccuc ccccguugcc ccucuggauc cacugcuuaa      480

auacggacga ggacagggcc cugucuccuc agcuucaggc accaccacug accugggaca      540

gugaaucgac aaugccgucu ucugucucgu ggggcauccu ccugcuggca ggccugugcu      600

gccugguccc ugucucccug gcugaggauc cccagggaga ugcugcccag aagacagaua      660

caucccacca ugaucaggau cacccaaccu ucaacaagau cacccccaac cuggcugagu      720

ucgccuucag ccuauaccgc cagcuggcac accaguccaa cagcaccaau aucuucuucu      780

ccccagugag caucgcuaca gccuuugcaa ugcucucccu ggggaccaag gcugacacuc      840

acgaugaaau ccuggagggc cugaauuuca accucacgga gauuccggag gcucagaucc      900

augaaggcuu ccaggaacuc cuccguaccc ucaaccagcc agacagccag cuccagcuga      960

ccaccggcaa uggccuguuc cucagcgagg gccugaagcu aguggauaag uuuuuggagg     1020

auguuaaaaa guuguaccac ucagaagccu ucacugucaa cuucggggac accgaagagg     1080

ccaagaaaca gaucaacgau uacguggaga aggguacuca agggaaaauu guggauuugg     1140

ucaaggagcu ugacagagac acaguuuuug cucuggugaa uuacaucuuc uuuaaaggca     1200

aaugggagag acccuuugaa gucaaggaca ccgaggaaga ggacuuccac guggaccagg     1260

ugaccaccgu gaaggugccu augaugaagc guuuaggcau guuuaacauc cagcacugua     1320

agaagcuguc cagcugggug cugcugauga aauaccuggg caaugccacc gccaucuucu     1380

uccugccuga ugaggggaaa cuacagcacc uggaaaauga acucacccac gauaucauca     1440

ccaaguuccu ggaaaaugaa gacagaaggu cugccagcuu acauuuaccc aaacugucca     1500

uuacuggaac cuaugaucug aagagcgucc ugggucaacu gggcaucacu aaggucuuca     1560

gcaauggggc ugaccucucc ggggucacag aggaggcacc ccugaagcuc uccaaggccg     1620

ugcauaaggc ugugcugacc aucgacgaga aagggacuga agcugcuggg gccauguuuu     1680

uagaggccau acccaugucu aucccccccg aggucaaguu caacaaaccc uuugucuucu     1740

uaaugauuga acaaaauacc aagucucccc ucuucauggg aaaaguggug aaucccaccc     1800

aaaaauaacu gccucucgcu ccucaacccc uccccuccau cccuggcccc cucccuggau     1860

gacauuaaag aaggguugag cuggucccug ccugcaugug acuguaaauc ccucccaugu     1920

uuucucugag ucucccuuug ccugcugagg cuguaugugg gcuccaggua acagugcugu     1980

cuucgggccc ccugaacugu guucauggag caucuggcug gguaggcaca ugcugggcuu     2040

gaauccaggg gggacugaau ccucagcuua cggaccuggg cccaucuguu ucuggagggc     2100

uccagucuuc cuuguccugu cuuggagucc ccaagaagga aucacagggg aggaaccaga     2160

uaccagccau gaccccaggc uccaccaagc aucuucaugu cccccugcuc aucccccacu     2220

cccccccacc cagaguugcu cauccugcca gggcuggcug ugcccacccc aaggcugccc     2280

uccugggggc cccagaacug ccugaucgug ccguggccca guuuuguggc aucugcagca     2340

acacaagaga gaggacaaug uccuccucuu gacccgcugu caccuaacca gacucgggcc     2400

cugcaccucu caggcacuuc uggaaaauga cugaggcaga uucuuccuga agcccauucu     2460

ccauggggca acaaggacac cuauucuguc cuuguccuuc caucgcugcc ccagaaagcc     2520

ucacauaucu ccguuuagaa ucaggucccu ucuccccaga ugaagaggag ggucucugcu     2580

uuguuuucuc uaucuccucc ucagacuuga ccaggcccag caggccccag aagaccauua     2640

cccuauaucc cuucuccucc cuagucacau ggccauaggc cugcugaugg cucaggaagg     2700

ccauugcaag gacuccucag cuaugggaga ggaagcacau cacccauuga cccccgcaac     2760

cccucccuuu ccuccucuga gucccgacug gggccacaug cagccugacu ucuuugugcc     2820

uguugcuguc ccugcagucu ucagagggcc accgcagcuc cagugccacg gcaggaggcu     2880

guuccugaau agccccugug guaagggcca ggagaguccu uccauccucc aaggcccugc     2940

uaaaggacac agcagccagg aaguccccug ggccccuagc ugaaggacag ccugcucccu     3000

ccgucucuac caggaauggc cuuguccuau ggaaggcacu gccccauccc aaacuaaucu     3060

aggaaucacu gucuaaccac ucacugucau gaauguguac uuaaaggaug agguugaguc     3120

auaccaaaua gugauuucga uaguucaaaa uggugaaauu agcaauucua caugauucag     3180

ucuaaucaau ggauaccgac uguuucccac acaagucucc uguucucuua agcuuacuca     3240

cugacagccu uucacucucc acaaauacau uaaagauaug gccaucacca agcccccuag     3300

gaugacacca gaccugagag ucugaagacc uggauccaag uucugacuuu ucccccugac     3360

agcuguguga ccuucgugaa gucgccaaac cucucugagc cccagucauu gcuaguaaga     3420

ccugccuuug aguugguaug auguucaagu uagauaacaa aauguuuaua cccauuagaa     3480

cagagaauaa auagaacuac auuucuugca                                      3510


<210>  14
<211>  3303
<212>  RNA
<213>  Homo sapiens

<400>  14
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagcagc      240

cucccccguu gccccucugg auccacugcu uaaauacgga cgaggacagg gcccugucuc      300

cucagcuuca ggcaccacca cugaccuggg acagugaauc gacaaugccg ucuucugucu      360

cguggggcau ccuccugcug gcaggccugu gcugccuggu cccugucucc cuggcugagg      420

auccccaggg agaugcugcc cagaagacag auacauccca ccaugaucag gaucacccaa      480

ccuucaacaa gaucaccccc aaccuggcug aguucgccuu cagccuauac cgccagcugg      540

cacaccaguc caacagcacc aauaucuucu ucuccccagu gagcaucgcu acagccuuug      600

caaugcucuc ccuggggacc aaggcugaca cucacgauga aauccuggag ggccugaauu      660

ucaaccucac ggagauuccg gaggcucaga uccaugaagg cuuccaggaa cuccuccgua      720

cccucaacca gccagacagc cagcuccagc ugaccaccgg caauggccug uuccucagcg      780

agggccugaa gcuaguggau aaguuuuugg aggauguuaa aaaguuguac cacucagaag      840

ccuucacugu caacuucggg gacaccgaag aggccaagaa acagaucaac gauuacgugg      900

agaaggguac ucaagggaaa auuguggauu uggucaagga gcuugacaga gacacaguuu      960

uugcucuggu gaauuacauc uucuuuaaag gcaaauggga gagacccuuu gaagucaagg     1020

acaccgagga agaggacuuc cacguggacc aggugaccac cgugaaggug ccuaugauga     1080

agcguuuagg cauguuuaac auccagcacu guaagaagcu guccagcugg gugcugcuga     1140

ugaaauaccu gggcaaugcc accgccaucu ucuuccugcc ugaugagggg aaacuacagc     1200

accuggaaaa ugaacucacc cacgauauca ucaccaaguu ccuggaaaau gaagacagaa     1260

ggucugccag cuuacauuua cccaaacugu ccauuacugg aaccuaugau cugaagagcg     1320

uccuggguca acugggcauc acuaaggucu ucagcaaugg ggcugaccuc uccgggguca     1380

cagaggaggc accccugaag cucuccaagg ccgugcauaa ggcugugcug accaucgacg     1440

agaaagggac ugaagcugcu ggggccaugu uuuuagaggc cauacccaug ucuauccccc     1500

ccgaggucaa guucaacaaa cccuuugucu ucuuaaugau ugaacaaaau accaagucuc     1560

cccucuucau gggaaaagug gugaauccca cccaaaaaua acugccucuc gcuccucaac     1620

cccuccccuc caucccuggc ccccucccug gaugacauua aagaaggguu gagcuggucc     1680

cugccugcau gugacuguaa aucccuccca uguuuucucu gagucucccu uugccugcug     1740

aggcuguaug ugggcuccag guaacagugc ugucuucggg cccccugaac uguguucaug     1800

gagcaucugg cuggguaggc acaugcuggg cuugaaucca ggggggacug aauccucagc     1860

uuacggaccu gggcccaucu guuucuggag ggcuccaguc uuccuugucc ugucuuggag     1920

uccccaagaa ggaaucacag gggaggaacc agauaccagc caugacccca ggcuccacca     1980

agcaucuuca ugucccccug cucauccccc acuccccccc acccagaguu gcucauccug     2040

ccagggcugg cugugcccac cccaaggcug cccuccuggg ggccccagaa cugccugauc     2100

gugccguggc ccaguuuugu ggcaucugca gcaacacaag agagaggaca auguccuccu     2160

cuugacccgc ugucaccuaa ccagacucgg gcccugcacc ucucaggcac uucuggaaaa     2220

ugacugaggc agauucuucc ugaagcccau ucuccauggg gcaacaagga caccuauucu     2280

guccuugucc uuccaucgcu gccccagaaa gccucacaua ucuccguuua gaaucagguc     2340

ccuucucccc agaugaagag gagggucucu gcuuuguuuu cucuaucucc uccucagacu     2400

ugaccaggcc cagcaggccc cagaagacca uuacccuaua ucccuucucc ucccuaguca     2460

cauggccaua ggccugcuga uggcucagga aggccauugc aaggacuccu cagcuauggg     2520

agaggaagca caucacccau ugacccccgc aaccccuccc uuuccuccuc ugagucccga     2580

cuggggccac augcagccug acuucuuugu gccuguugcu gucccugcag ucuucagagg     2640

gccaccgcag cuccagugcc acggcaggag gcuguuccug aauagccccu gugguaaggg     2700

ccaggagagu ccuuccaucc uccaaggccc ugcuaaagga cacagcagcc aggaaguccc     2760

cugggccccu agcugaagga cagccugcuc ccuccgucuc uaccaggaau ggccuugucc     2820

uauggaaggc acugccccau cccaaacuaa ucuaggaauc acugucuaac cacucacugu     2880

caugaaugug uacuuaaagg augagguuga gucauaccaa auagugauuu cgauaguuca     2940

aaauggugaa auuagcaauu cuacaugauu cagucuaauc aauggauacc gacuguuucc     3000

cacacaaguc uccuguucuc uuaagcuuac ucacugacag ccuuucacuc uccacaaaua     3060

cauuaaagau auggccauca ccaagccccc uaggaugaca ccagaccuga gagucugaag     3120

accuggaucc aaguucugac uuuucccccu gacagcugug ugaccuucgu gaagucgcca     3180

aaccucucug agccccaguc auugcuagua agaccugccu uugaguuggu augauguuca     3240

aguuagauaa caaaauguuu auacccauua gaacagagaa uaaauagaac uacauuucuu     3300

gca                                                                   3303


<210>  15
<211>  3300
<212>  RNA
<213>  Homo sapiens

<400>  15
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaagccuc      240

ccccguugcc ccucuggauc cacugcuuaa auacggacga ggacagggcc cugucuccuc      300

agcuucaggc accaccacug accugggaca gugaaucgac aaugccgucu ucugucucgu      360

ggggcauccu ccugcuggca ggccugugcu gccugguccc ugucucccug gcugaggauc      420

cccagggaga ugcugcccag aagacagaua caucccacca ugaucaggau cacccaaccu      480

ucaacaagau cacccccaac cuggcugagu ucgccuucag ccuauaccgc cagcuggcac      540

accaguccaa cagcaccaau aucuucuucu ccccagugag caucgcuaca gccuuugcaa      600

ugcucucccu ggggaccaag gcugacacuc acgaugaaau ccuggagggc cugaauuuca      660

accucacgga gauuccggag gcucagaucc augaaggcuu ccaggaacuc cuccguaccc      720

ucaaccagcc agacagccag cuccagcuga ccaccggcaa uggccuguuc cucagcgagg      780

gccugaagcu aguggauaag uuuuuggagg auguuaaaaa guuguaccac ucagaagccu      840

ucacugucaa cuucggggac accgaagagg ccaagaaaca gaucaacgau uacguggaga      900

aggguacuca agggaaaauu guggauuugg ucaaggagcu ugacagagac acaguuuuug      960

cucuggugaa uuacaucuuc uuuaaaggca aaugggagag acccuuugaa gucaaggaca     1020

ccgaggaaga ggacuuccac guggaccagg ugaccaccgu gaaggugccu augaugaagc     1080

guuuaggcau guuuaacauc cagcacugua agaagcuguc cagcugggug cugcugauga     1140

aauaccuggg caaugccacc gccaucuucu uccugccuga ugaggggaaa cuacagcacc     1200

uggaaaauga acucacccac gauaucauca ccaaguuccu ggaaaaugaa gacagaaggu     1260

cugccagcuu acauuuaccc aaacugucca uuacuggaac cuaugaucug aagagcgucc     1320

ugggucaacu gggcaucacu aaggucuuca gcaauggggc ugaccucucc ggggucacag     1380

aggaggcacc ccugaagcuc uccaaggccg ugcauaaggc ugugcugacc aucgacgaga     1440

aagggacuga agcugcuggg gccauguuuu uagaggccau acccaugucu aucccccccg     1500

aggucaaguu caacaaaccc uuugucuucu uaaugauuga acaaaauacc aagucucccc     1560

ucuucauggg aaaaguggug aaucccaccc aaaaauaacu gccucucgcu ccucaacccc     1620

uccccuccau cccuggcccc cucccuggau gacauuaaag aaggguugag cuggucccug     1680

ccugcaugug acuguaaauc ccucccaugu uuucucugag ucucccuuug ccugcugagg     1740

cuguaugugg gcuccaggua acagugcugu cuucgggccc ccugaacugu guucauggag     1800

caucuggcug gguaggcaca ugcugggcuu gaauccaggg gggacugaau ccucagcuua     1860

cggaccuggg cccaucuguu ucuggagggc uccagucuuc cuuguccugu cuuggagucc     1920

ccaagaagga aucacagggg aggaaccaga uaccagccau gaccccaggc uccaccaagc     1980

aucuucaugu cccccugcuc aucccccacu cccccccacc cagaguugcu cauccugcca     2040

gggcuggcug ugcccacccc aaggcugccc uccugggggc cccagaacug ccugaucgug     2100

ccguggccca guuuuguggc aucugcagca acacaagaga gaggacaaug uccuccucuu     2160

gacccgcugu caccuaacca gacucgggcc cugcaccucu caggcacuuc uggaaaauga     2220

cugaggcaga uucuuccuga agcccauucu ccauggggca acaaggacac cuauucuguc     2280

cuuguccuuc caucgcugcc ccagaaagcc ucacauaucu ccguuuagaa ucaggucccu     2340

ucuccccaga ugaagaggag ggucucugcu uuguuuucuc uaucuccucc ucagacuuga     2400

ccaggcccag caggccccag aagaccauua cccuauaucc cuucuccucc cuagucacau     2460

ggccauaggc cugcugaugg cucaggaagg ccauugcaag gacuccucag cuaugggaga     2520

ggaagcacau cacccauuga cccccgcaac cccucccuuu ccuccucuga gucccgacug     2580

gggccacaug cagccugacu ucuuugugcc uguugcuguc ccugcagucu ucagagggcc     2640

accgcagcuc cagugccacg gcaggaggcu guuccugaau agccccugug guaagggcca     2700

ggagaguccu uccauccucc aaggcccugc uaaaggacac agcagccagg aaguccccug     2760

ggccccuagc ugaaggacag ccugcucccu ccgucucuac caggaauggc cuuguccuau     2820

ggaaggcacu gccccauccc aaacuaaucu aggaaucacu gucuaaccac ucacugucau     2880

gaauguguac uuaaaggaug agguugaguc auaccaaaua gugauuucga uaguucaaaa     2940

uggugaaauu agcaauucua caugauucag ucuaaucaau ggauaccgac uguuucccac     3000

acaagucucc uguucucuua agcuuacuca cugacagccu uucacucucc acaaauacau     3060

uaaagauaug gccaucacca agcccccuag gaugacacca gaccugagag ucugaagacc     3120

uggauccaag uucugacuuu ucccccugac agcuguguga ccuucgugaa gucgccaaac     3180

cucucugagc cccagucauu gcuaguaaga ccugccuuug aguugguaug auguucaagu     3240

uagauaacaa aauguuuaua cccauuagaa cagagaauaa auagaacuac auuucuugca     3300


<210>  16
<211>  3199
<212>  RNA
<213>  Homo sapiens

<400>  16
ugggcaggaa cugggcacug ugcccagggc augcacugcc uccacgcagc aacccucaga       60

guccugagcu gaaccaagaa ggaggagggg gucgggccuc cgaggaaggc cuagccgcug      120

cugcugccag gaauuccagg uuggaggggc ggcaaccucc ugccagccuu caggccacuc      180

uccugugccu gccagaagag acagagcuug aggagagcuu gaggagagca ggaaaggaca      240

augccgucuu cugucucgug gggcauccuc cugcuggcag gccugugcug ccuggucccu      300

gucucccugg cugaggaucc ccagggagau gcugcccaga agacagauac aucccaccau      360

gaucaggauc acccaaccuu caacaagauc acccccaacc uggcugaguu cgccuucagc      420

cuauaccgcc agcuggcaca ccaguccaac agcaccaaua ucuucuucuc cccagugagc      480

aucgcuacag ccuuugcaau gcucucccug gggaccaagg cugacacuca cgaugaaauc      540

cuggagggcc ugaauuucaa ccucacggag auuccggagg cucagaucca ugaaggcuuc      600

caggaacucc uccguacccu caaccagcca gacagccagc uccagcugac caccggcaau      660

ggccuguucc ucagcgaggg ccugaagcua guggauaagu uuuuggagga uguuaaaaag      720

uuguaccacu cagaagccuu cacugucaac uucggggaca ccgaagaggc caagaaacag      780

aucaacgauu acguggagaa ggguacucaa gggaaaauug uggauuuggu caaggagcuu      840

gacagagaca caguuuuugc ucuggugaau uacaucuucu uuaaaggcaa augggagaga      900

cccuuugaag ucaaggacac cgaggaagag gacuuccacg uggaccaggu gaccaccgug      960

aaggugccua ugaugaagcg uuuaggcaug uuuaacaucc agcacuguaa gaagcugucc     1020

agcugggugc ugcugaugaa auaccugggc aaugccaccg ccaucuucuu ccugccugau     1080

gaggggaaac uacagcaccu ggaaaaugaa cucacccacg auaucaucac caaguuccug     1140

gaaaaugaag acagaagguc ugccagcuua cauuuaccca aacuguccau uacuggaacc     1200

uaugaucuga agagcguccu gggucaacug ggcaucacua aggucuucag caauggggcu     1260

gaccucuccg gggucacaga ggaggcaccc cugaagcucu ccaaggccgu gcauaaggcu     1320

gugcugacca ucgacgagaa agggacugaa gcugcugggg ccauguuuuu agaggccaua     1380

cccaugucua ucccccccga ggucaaguuc aacaaacccu uugucuucuu aaugauugaa     1440

caaaauacca agucuccccu cuucauggga aaagugguga aucccaccca aaaauaacug     1500

ccucucgcuc cucaaccccu ccccuccauc ccuggccccc ucccuggaug acauuaaaga     1560

aggguugagc uggucccugc cugcauguga cuguaaaucc cucccauguu uucucugagu     1620

cucccuuugc cugcugaggc uguauguggg cuccagguaa cagugcuguc uucgggcccc     1680

cugaacugug uucauggagc aucuggcugg guaggcacau gcugggcuug aauccagggg     1740

ggacugaauc cucagcuuac ggaccugggc ccaucuguuu cuggagggcu ccagucuucc     1800

uuguccuguc uuggaguccc caagaaggaa ucacagggga ggaaccagau accagccaug     1860

accccaggcu ccaccaagca ucuucauguc ccccugcuca ucccccacuc ccccccaccc     1920

agaguugcuc auccugccag ggcuggcugu gcccacccca aggcugcccu ccugggggcc     1980

ccagaacugc cugaucgugc cguggcccag uuuuguggca ucugcagcaa cacaagagag     2040

aggacaaugu ccuccucuug acccgcuguc accuaaccag acucgggccc ugcaccucuc     2100

aggcacuucu ggaaaaugac ugaggcagau ucuuccugaa gcccauucuc cauggggcaa     2160

caaggacacc uauucugucc uuguccuucc aucgcugccc cagaaagccu cacauaucuc     2220

cguuuagaau caggucccuu cuccccagau gaagaggagg gucucugcuu uguuuucucu     2280

aucuccuccu cagacuugac caggcccagc aggccccaga agaccauuac ccuauauccc     2340

uucuccuccc uagucacaug gccauaggcc ugcugauggc ucaggaaggc cauugcaagg     2400

acuccucagc uaugggagag gaagcacauc acccauugac ccccgcaacc ccucccuuuc     2460

cuccucugag ucccgacugg ggccacaugc agccugacuu cuuugugccu guugcugucc     2520

cugcagucuu cagagggcca ccgcagcucc agugccacgg caggaggcug uuccugaaua     2580

gccccugugg uaagggccag gagaguccuu ccauccucca aggcccugcu aaaggacaca     2640

gcagccagga aguccccugg gccccuagcu gaaggacagc cugcucccuc cgucucuacc     2700

aggaauggcc uuguccuaug gaaggcacug ccccauccca aacuaaucua ggaaucacug     2760

ucuaaccacu cacugucaug aauguguacu uaaaggauga gguugaguca uaccaaauag     2820

ugauuucgau aguucaaaau ggugaaauua gcaauucuac augauucagu cuaaucaaug     2880

gauaccgacu guuucccaca caagucuccu guucucuuaa gcuuacucac ugacagccuu     2940

ucacucucca caaauacauu aaagauaugg ccaucaccaa gcccccuagg augacaccag     3000

accugagagu cugaagaccu ggauccaagu ucugacuuuu cccccugaca gcugugugac     3060

cuucgugaag ucgccaaacc ucucugagcc ccagucauug cuaguaagac cugccuuuga     3120

guugguauga uguucaaguu agauaacaaa auguuuauac ccauuagaac agagaauaaa     3180

uagaacuaca uuucuugca                                                  3199


<210>  17
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense 901

<400>  17
ccuggaggcu ugcugaaggc uguaugcugu aagcuggcag accuucuguc guuuuggcca       60

cugacugacg acagaagcug ccagcuuaca ggacacaagg ccuguuacua gcacucacau      120

ggaacaaaug gcc                                                         133


<210>  18
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense 914

<400>  18
ccuggaggcu ugcugaaggc uguaugcuga auguaagcug gcagaccuuc guuuuggcca       60

cugacugacg aaggucucag cuuacauuca ggacacaagg ccuguuacua gcacucacau      120

ggaacaaaug gcc                                                         133


<210>  19
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense 943

<400>  19
ccuggaggcu ugcugaaggc uguaugcuga uagguuccag uaauggacag guuuuggcca       60

cugacugacc uguccaucug gaaccuauca ggacacaagg ccuguuacua gcacucacau      120

ggaacaaaug gcc                                                         133


<210>  20
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Hardened alpha-1 antitrypsin

<400>  20
augccgucuu cugucucgug gggcauccuc cugcuggcag gccugugcug ccuggucccu       60

gucucccugg cugaggaucc ccagggagau gcugcccaga agacagauac aucccaccau      120

gaucaggauc acccaaccuu caacaagauc acccccaacc uggcugaguu cgccuucagc      180

cuauaccgcc agcuggcaca ccaguccaac agcaccaaua ucuucuucuc cccagugagc      240

aucgcuacag ccuuugcaau gcucucccug gggaccaagg cugacacuca cgaugaaauc      300

cuggagggcc ugaauuucaa ccucacggag auuccggagg cucagaucca ugaaggcuuc      360

caggaacucc uccguacccu caaccagcca gacagccagc uccagcugac caccggcaau      420

ggccuguucc ucagcgaggg ccugaagcua guggauaagu uuuuggagga uguuaaaaag      480

uuguaccacu cagaagccuu cacugucaac uucggggaca ccgaagaggc caagaaacag      540

aucaacgauu acguggagaa ggguacucaa gggaaaauug uggauuuggu caaggagcuu      600

gacagagaca caguuuuugc ucuggugaau uacaucuucu uuaaaggcaa augggagaga      660

cccuuugaag ucaaggacac cgaggaagag gacuuccacg uggaccaggu gaccaccgug      720

aaggugccua ugaugaagcg uuuaggcaug uuuaacaucc agcacuguaa gaagcugucc      780

agcugggugc ugcugaugaa auaccugggc aaugccaccg ccaucuucuu ccugccugau      840

gaggggaaac uacagcaccu ggaaaaugaa cucacccacg auaucaucac caaguuccug      900

gaaaaugaag aucgccguag cgcuucucug caccugccca aguuaagcau caccggcacg      960

uacgaccuga agagcguccu gggucaacug ggcaucacua aggucuucag caauggggcu     1020

gaccucuccg gggucacaga ggaggcaccc cugaagcucu ccaaggccgu gcauaaggcu     1080

gugcugacca ucgacgagaa agggacugaa gcugcugggg ccauguuuuu agaggccaua     1140

cccaugucua ucccccccga ggucaaguuc aacaaacccu uugucuucuu aaugauugaa     1200

caaaauacca agucuccccu cuucauggga aaagugguga aucccaccca aaaa           1254


<210>  21
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miRNA 910

<400>  21
uaagcuggca gaccuucugu cguuuuggcc acugagugac gacagaagcu gccagcuua        59


<210>  22
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miRNA 914

<400>  22
aauguaagcu ggcagaccuu cguuuuggcc acugacugac gaaggucuca gcuuacauu        59


<210>  23
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miRNA 943

<400>  23
auagguucca guaauggaca gguuuggcca cugacugacc uguccaucug gaaccuau         58


<210>  24
<211>  7804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Double 6xmiR-CB-GFP


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  inverted terminal repeats (ITR)

<220>
<221>  enhancer
<222>  (182)..(548)
<223>  Enhancer

<220>
<221>  promoter
<222>  (549)..(1482)
<223>  Chicken beta actin promoter

<220>
<221>  Intron
<222>  (826)..(1482)
<223>  intron

<220>
<221>  misc_feature
<222>  (1502)..(1529)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1530)..(1550)
<223>  Antisense 901

<220>
<221>  misc_signal
<222>  (1570)..(1588)

<220>
<221>  misc_feature
<222>  (1593)..(1633)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1646)..(1674)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1675)..(1695)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (1715)..(1733)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1738)..(1778)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1791)..(1819)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1820)..(1840)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (1860)..(1878)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1883)..(1923)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1936)..(2035)
<223>  Globin

<220>
<221>  gene
<222>  (2072)..(2788)
<223>  Green Fluorescent Protein (GFP)

<220>
<221>  misc_feature
<222>  (2818)..(2845)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (2846)..(2866)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (2886)..(2904)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (2909)..(2949)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (2962)..(2990)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (2991)..(3011)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (3031)..(3049)
<223>  sense delta 2

<220>
<221>  misc_feature
<222>  (3054)..(3094)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (3107)..(3135)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3136)..(3156)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (3176)..(3194)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3199)..(3239)
<223>  3' miR

<220>
<221>  polyA_signal
<222>  (3258)..(3470)
<223>  poly A tail

<220>
<221>  promoter
<222>  (3611)..(3739)
<223>  thymidine kinase promoter (Tkp)

<220>
<221>  gene
<222>  (3751)..(4554)
<223>  Neo resistance gene

<220>
<221>  misc_feature
<222>  (4807)..(4952)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  gene
<222>  (5972)..(6832)
<223>  Ampicillin resistance gene

<400>  24
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagggc cctttgtgcg ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc     1140

ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg     1200

gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg     1260

agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcgac cggtgctagc     1500

cctggaggct tgctgaaggc tgtatgctgt aagctggcag accttctgtc gttttggcca     1560

ctgactgacg acagaagctg ccagcttaca ggacacaagg cctgttacta gcactcacat     1620

ggaacaaatg gccaccggta tgcatcctgg aggcttgctg aaggctgtat gctgaatgta     1680

agctggcaga ccttcgtttt ggccactgac tgacgaaggt ctcagcttac attcaggaca     1740

caaggcctgt tactagcact cacatggaac aaatggccgc tagctcgcga cctggaggct     1800

tgctgaaggc tgtatgctga taggttccag taatggacag gttttggcca ctgactgacc     1860

tgtccatctg gaacctatca ggacacaagg cctgttacta gcactcacat ggaacaaatg     1920

gcctcgcgat gcatctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca     1980

gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattcctcga     2040

agatctaggc ctgcaggcgg ccgccgccac catgagcaag ggcgaggaac tgttcactgg     2100

cgtggtccca attctcgtgg aactggatgg cgatgtgaat gggcacaaat tttctgtcag     2160

cggagagggt gaaggtgatg ccacatacgg aaagctcacc ctgaaattca tctgcaccac     2220

tggaaagctc cctgtgccat ggccaacact ggtcactacc ctgacctatg gcgtgcagtg     2280

cttttccaga tacccagacc atatgaagca gcatgacttt ttcaagagcg ccatgcccga     2340

gggctatgtg caggagagaa ccatcttttt caaagatgac gggaactaca agacccgcgc     2400

tgaagtcaag ttcgaaggtg acaccctggt gaatagaatc gagctgaagg gcattgactt     2460

taaggaggat ggaaacattc tcggccacaa gctggaatac aactataact cccacaatgt     2520

gtacatcatg gccgacaagc aaaagaatgg catcaaggtc aacttcaaga tcagacacaa     2580

cattgaggat ggatccgtgc agctggccga ccattatcaa cagaacactc caatcggcga     2640

cggccctgtg ctcctcccag acaaccatta cctgtccacc cagtctgccc tgtctaaaga     2700

tcccaacgaa aagagagacc acatggtcct gctggagttt gtgaccgctg ctgggatcac     2760

acatggcatg gacgagctgt acaagtgacc tgcaggcgcc ggcgaccggt gctagccctg     2820

gaggcttgct gaaggctgta tgctgtaagc tggcagacct tctgtcgttt tggccactga     2880

ctgacgacag aagctgccag cttacaggac acaaggcctg ttactagcac tcacatggaa     2940

caaatggcca ccggtatgca tcctggaggc ttgctgaagg ctgtatgctg aatgtaagct     3000

ggcagacctt cgttttggcc actgactgac gaaggtctca gcttacattc aggacacaag     3060

gcctgttact agcactcaca tggaacaaat ggccgctagc tcgcgacctg gaggcttgct     3120

gaaggctgta tgctgatagg ttccagtaat ggacaggttt tggccactga ctgacctgtc     3180

catctggaac ctatcaggac acaaggcctg ttactagcac tcacatggaa caaatggcct     3240

cgcgatgcat ctagagcggc cgcggggatc cagacatgat aagatacatt gatgagtttg     3300

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     3360

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     3420

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttagtcgacc tcgagcagtg     3480

tggttttgca agaggaagca aaaagcctct ccacccaggc ctggaatgtt tccacccaag     3540

tcgaaggcag tgtggttttg caagaggaag caaaaagcct ctccacccag gcctggaatg     3600

tttccaccca atgtcgagca accccgccca gcgtcttgtc attggcgaat tcgaacacgc     3660

agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg acgcgtgtgg     3720

cctcgaacac cgagcgaccc tgcagccaat atgggatcgg ccattgaaca agatggattg     3780

cacgcaggtt ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag     3840

acaatcggct gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt     3900

tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta     3960

tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg     4020

ggaagggact ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt     4080

gctcctgccg agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat     4140

ccggctacct gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg     4200

atggaagccg gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca     4260

gccgaactgt tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc     4320

catggcgatg cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc     4380

gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat     4440

attgctgaag agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc     4500

gctcccgatt cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgaggggat     4560

ccgtcgacta gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt     4620

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4680

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4740

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggag     4800

agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4860

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga     4920

gcgagcgagc gcgcagagag ggagtggcca accccccccc ccccccccct gcagccctgc     4980

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt     5040

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     5100

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     5160

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     5220

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     5280

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     5340

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     5400

tttctcaatg ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     5460

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     5520

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     5580

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     5640

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     5700

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     5760

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     5820

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     5880

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     5940

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     6000

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     6060

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     6120

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     6180

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     6240

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg     6300

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     6360

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     6420

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     6480

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     6540

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     6600

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     6660

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     6720

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     6780

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     6840

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     6900

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     6960

ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga     7020

ggccctttcg tctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc     7080

cggagacggt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg     7140

cgtcagcggg tgttggcggg tgtcggggct ggcttaacta tgcggcatca gagcagattg     7200

tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc     7260

gcatcaggaa attgtaaacg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat     7320

cagctcattt tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata     7380

gaccgagata gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt     7440

ggactccaac gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc     7500

atcaccctaa tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa     7560

agggagcccc cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg     7620

gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt     7680

aaccaccaca cccgccgcgc ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt     7740

caggctacgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccaggc     7800

tgca                                                                  7804


<210>  25
<211>  7667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PolyA-3XmiR-CB-GFP


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  enhancer
<222>  (182)..(548)
<223>  Enhancer

<220>
<221>  promoter
<222>  (549)..(1795)
<223>  Chicken beta actin promoter

<220>
<221>  Intron
<222>  (826)..(1795)
<223>  Intron

<220>
<221>  misc_feature
<222>  (1796)..(1898)
<223>  Globin

<220>
<221>  gene
<222>  (1935)..(2651)
<223>  Green fluorescent protein (GFP)

<220>
<221>  misc_feature
<222>  (2681)..(2708)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (2709)..(2729)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (2749)..(2767)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (2772)..(2812)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (2854)..(2874)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (2894)..(2912)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (2917)..(2957)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (2970)..(2998)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (2999)..(3019)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (3039)..(3057)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3062)..(3102)
<223>  3' miR

<220>
<221>  polyA_signal
<222>  (3121)..(3333)
<223>  polyA tail

<220>
<221>  promoter
<222>  (3474)..(3602)
<223>  thymidine kinase promoter (Tkp)

<220>
<221>  gene
<222>  (3614)..(4417)
<223>  Neomycin resistance gene

<220>
<221>  misc_feature
<222>  (4670)..(4815)
<223>  inverted terminal repeats (ITR)

<220>
<221>  gene
<222>  (5835)..(6695)
<223>  Ampicillin resistance gene

<400>  25
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagggc cctttgtgcg ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc     1140

ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg     1200

gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg     1260

agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattcct cgaagatcta ggcctgcagg     1920

cggccgccgc caccatgagc aagggcgagg aactgttcac tggcgtggtc ccaattctcg     1980

tggaactgga tggcgatgtg aatgggcaca aattttctgt cagcggagag ggtgaaggtg     2040

atgccacata cggaaagctc accctgaaat tcatctgcac cactggaaag ctccctgtgc     2100

catggccaac actggtcact accctgacct atggcgtgca gtgcttttcc agatacccag     2160

accatatgaa gcagcatgac tttttcaaga gcgccatgcc cgagggctat gtgcaggaga     2220

gaaccatctt tttcaaagat gacgggaact acaagacccg cgctgaagtc aagttcgaag     2280

gtgacaccct ggtgaataga atcgagctga agggcattga ctttaaggag gatggaaaca     2340

ttctcggcca caagctggaa tacaactata actcccacaa tgtgtacatc atggccgaca     2400

agcaaaagaa tggcatcaag gtcaacttca agatcagaca caacattgag gatggatccg     2460

tgcagctggc cgaccattat caacagaaca ctccaatcgg cgacggccct gtgctcctcc     2520

cagacaacca ttacctgtcc acccagtctg ccctgtctaa agatcccaac gaaaagagag     2580

accacatggt cctgctggag tttgtgaccg ctgctgggat cacacatggc atggacgagc     2640

tgtacaagtg acctgcaggc gccggcgacc ggtgctagcc ctggaggctt gctgaaggct     2700

gtatgctgta agctggcaga ccttctgtcg ttttggccac tgactgacga cagaagctgc     2760

cagcttacag gacacaaggc ctgttactag cactcacatg gaacaaatgg ccaccggtat     2820

gcatcctgga ggcttgctga aggctgtatg ctgaatgtaa gctggcagac cttcgttttg     2880

gccactgact gacgaaggtc tcagcttaca ttcaggacac aaggcctgtt actagcactc     2940

acatggaaca aatggccgct agctcgcgac ctggaggctt gctgaaggct gtatgctgat     3000

aggttccagt aatggacagg ttttggccac tgactgacct gtccatctgg aacctatcag     3060

gacacaaggc ctgttactag cactcacatg gaacaaatgg cctcgcgatg catctagagc     3120

ggccgcgggg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga     3180

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc     3240

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt     3300

cagggggagg tgtgggaggt tttttagtcg acctcgagca gtgtggtttt gcaagaggaa     3360

gcaaaaagcc tctccaccca ggcctggaat gtttccaccc aagtcgaagg cagtgtggtt     3420

ttgcaagagg aagcaaaaag cctctccacc caggcctgga atgtttccac ccaatgtcga     3480

gcaaccccgc ccagcgtctt gtcattggcg aattcgaaca cgcagatgca gtcggggcgg     3540

cgcggtccca ggtccacttc gcatattaag gtgacgcgtg tggcctcgaa caccgagcga     3600

ccctgcagcc aatatgggat cggccattga acaagatgga ttgcacgcag gttctccggc     3660

cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga     3720

tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct     3780

gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac     3840

gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct     3900

attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt     3960

atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt     4020

cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt     4080

cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag     4140

gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt     4200

gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg     4260

tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg     4320

cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg     4380

catcgccttc tatcgccttc ttgacgagtt cttctgaggg gatccgtcga ctagagctcg     4440

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     4500

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     4560

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     4620

caagggggag gattgggaag acaatagcag gcatgctggg gagagatcta ggaaccccta     4680

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgcccgggca     4740

aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga     4800

gagggagtgg ccaacccccc cccccccccc cctgcagccc tgcattaatg aatcggccaa     4860

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     4920

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     4980

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     5040

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     5100

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     5160

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     5220

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc     5280

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     5340

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     5400

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     5460

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     5520

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     5580

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     5640

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     5700

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     5760

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     5820

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     5880

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     5940

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     6000

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     6060

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     6120

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     6180

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     6240

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     6300

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     6360

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     6420

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     6480

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     6540

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     6600

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     6660

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     6720

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     6780

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc     6840

attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg     6900

cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac ggtcacagct     6960

tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc     7020

gggtgtcggg gctggcttaa ctatgcggca tcagagcaga ttgtactgag agtgcaccat     7080

atgcggtgtg aaataccgca cagatgcgta aggagaaaat accgcatcag gaaattgtaa     7140

acgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc     7200

aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga     7260

gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag     7320

ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt     7380

ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta     7440

gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag     7500

cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg     7560

cgcttaatgc gccgctacag ggcgcgtcgc gccattcgcc attcaggcta cgcaactgtt     7620

gggaagggcg atcggtgcgg gcctcttcgc tattacgcca ggctgca                   7667


<210>  26
<211>  7337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Intronic-3XmiR-CB-GFP


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  enhancer
<222>  (182)..(548)
<223>  enhancer

<220>
<221>  promoter
<222>  (549)..(1482)
<223>  Chicken beta actin promoter

<220>
<221>  Intron
<222>  (826)..(1482)
<223>  Chicken beta actin intron

<220>
<221>  misc_feature
<222>  (1502)..(1529)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1530)..(1550)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (1570)..(1588)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1593)..(1633)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1646)..(1674)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1675)..(1695)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (1715)..(1733)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1738)..(1778)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1791)..(1819)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1820)..(1840)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (1860)..(1878)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1883)..(1923)
<223>  3' miR

<220>
<221>  gene
<222>  (2072)..(2788)
<223>  GFP

<220>
<221>  polyA_signal
<222>  (2789)..(3003)
<223>  polyA tail

<220>
<221>  promoter
<222>  (3144)..(3272)
<223>  thymidine kinase promoter (Tkp)

<220>
<221>  gene
<222>  (3284)..(4087)
<223>  Neomycin resistance gene

<220>
<221>  misc_feature
<222>  (4340)..(4485)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  gene
<222>  (5505)..(6365)
<223>  Ampicillin (complement)

<400>  26
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagggc cctttgtgcg ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc     1140

ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg     1200

gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg     1260

agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcgac cggtgctagc     1500

cctggaggct tgctgaaggc tgtatgctgt aagctggcag accttctgtc gttttggcca     1560

ctgactgacg acagaagctg ccagcttaca ggacacaagg cctgttacta gcactcacat     1620

ggaacaaatg gccaccggta tgcatcctgg aggcttgctg aaggctgtat gctgaatgta     1680

agctggcaga ccttcgtttt ggccactgac tgacgaaggt ctcagcttac attcaggaca     1740

caaggcctgt tactagcact cacatggaac aaatggccgc tagctcgcga cctggaggct     1800

tgctgaaggc tgtatgctga taggttccag taatggacag gttttggcca ctgactgacc     1860

tgtccatctg gaacctatca ggacacaagg cctgttacta gcactcacat ggaacaaatg     1920

gcctcgcgat gcatctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca     1980

gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattcctcga     2040

agatctaggc ctgcaggcgg ccgccgccac catgagcaag ggcgaggaac tgttcactgg     2100

cgtggtccca attctcgtgg aactggatgg cgatgtgaat gggcacaaat tttctgtcag     2160

cggagagggt gaaggtgatg ccacatacgg aaagctcacc ctgaaattca tctgcaccac     2220

tggaaagctc cctgtgccat ggccaacact ggtcactacc ctgacctatg gcgtgcagtg     2280

cttttccaga tacccagacc atatgaagca gcatgacttt ttcaagagcg ccatgcccga     2340

gggctatgtg caggagagaa ccatcttttt caaagatgac gggaactaca agacccgcgc     2400

tgaagtcaag ttcgaaggtg acaccctggt gaatagaatc gagctgaagg gcattgactt     2460

taaggaggat ggaaacattc tcggccacaa gctggaatac aactataact cccacaatgt     2520

gtacatcatg gccgacaagc aaaagaatgg catcaaggtc aacttcaaga tcagacacaa     2580

cattgaggat ggatccgtgc agctggccga ccattatcaa cagaacactc caatcggcga     2640

cggccctgtg ctcctcccag acaaccatta cctgtccacc cagtctgccc tgtctaaaga     2700

tcccaacgaa aagagagacc acatggtcct gctggagttt gtgaccgctg ctgggatcac     2760

acatggcatg gacgagctgt acaagtgagc ggccgcgggg atccagacat gataagatac     2820

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa     2880

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     2940

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttagtcg     3000

acctcgagca gtgtggtttt gcaagaggaa gcaaaaagcc tctccaccca ggcctggaat     3060

gtttccaccc aagtcgaagg cagtgtggtt ttgcaagagg aagcaaaaag cctctccacc     3120

caggcctgga atgtttccac ccaatgtcga gcaaccccgc ccagcgtctt gtcattggcg     3180

aattcgaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc gcatattaag     3240

gtgacgcgtg tggcctcgaa caccgagcga ccctgcagcc aatatgggat cggccattga     3300

acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga     3360

ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg     3420

gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga     3480

ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt     3540

tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct     3600

gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct     3660

gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg     3720

agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca     3780

ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga     3840

tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt     3900

ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt     3960

ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct     4020

ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt     4080

cttctgaggg gatccgtcga ctagagctcg ctgatcagcc tcgactgtgc cttctagttg     4140

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     4200

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     4260

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     4320

gcatgctggg gagagatcta ggaaccccta gtgatggagt tggccactcc ctctctgcgc     4380

gctcgctcgc tcactgaggc cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc     4440

ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg ccaacccccc cccccccccc     4500

cctgcagccc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg     4560

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     4620

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     4680

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     4740

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     4800

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     4860

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     4920

ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     4980

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     5040

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     5100

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     5160

tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca     5220

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     5280

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     5340

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     5400

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     5460

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     5520

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc     5580

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata     5640

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg     5700

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc     5760

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct     5820

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa     5880

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt     5940

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca     6000

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac     6060

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca     6120

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt     6180

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc     6240

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca     6300

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata     6360

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     6420

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     6480

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat     6540

aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga aaacctctga     6600

cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa     6660

gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca     6720

tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta     6780

aggagaaaat accgcatcag gaaattgtaa acgttaatat tttgttaaaa ttcgcgttaa     6840

atttttgtta aatcagctca ttttttaacc aataggccga aatcggcaaa atcccttata     6900

aatcaaaaga atagaccgag atagggttga gtgttgttcc agtttggaac aagagtccac     6960

tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc     7020

cactacgtga accatcaccc taatcaagtt ttttggggtc gaggtgccgt aaagcactaa     7080

atcggaaccc taaagggagc ccccgattta gagcttgacg gggaaagccg gcgaacgtgg     7140

cgagaaagga agggaagaaa gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg     7200

tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc gccgctacag ggcgcgtcgc     7260

gccattcgcc attcaggcta cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc     7320

tattacgcca ggctgca                                                    7337


<210>  27
<211>  8223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PolyA-3XmiR-CB-AAT


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  enhancer
<222>  (182)..(548)
<223>  enhancer

<220>
<221>  promoter
<222>  (549)..(1795)
<223>  Chicken beta actin promoter

<220>
<221>  Intron
<222>  (826)..(1795)
<223>  Intron

<220>
<221>  misc_feature
<222>  (1796)..(1898)
<223>  Globin

<220>
<221>  gene
<222>  (1921)..(3174)
<223>  Hardened alpha-1 antitrypsin (AAT)

<220>
<221>  misc_signal
<222>  (3175)..(3204)
<223>  Cmyc-tag

<220>
<221>  misc_feature
<222>  (3237)..(3264)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3265)..(3285)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (3305)..(3323)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3328)..(3368)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (3381)..(3409)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3410)..(3430)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (3450)..(3468)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3473)..(3513)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (3526)..(3554)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3555)..(3575)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (3595)..(3613)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3618)..(3658)
<223>  3' miR

<220>
<221>  polyA_signal
<222>  (3677)..(3889)
<223>  polyA tail

<220>
<221>  promoter
<222>  (4030)..(4158)
<223>  thymidine kinase promoter (Tkp)

<220>
<221>  gene
<222>  (4170)..(4973)
<223>  Neomycin resistance gene

<220>
<221>  misc_feature
<222>  (5226)..(5371)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  gene
<222>  (6391)..(7251)
<223>  Ampicillin resistance gene (complement)

<400>  27
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagggc cctttgtgcg ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc     1140

ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg     1200

gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg     1260

agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     1500

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     1560

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     1620

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1680

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     1740

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     1800

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     1860

tggttattgt gctgtctcat cattttggca aagaattcct cgaagatcta ggcctgcagg     1920

atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct     1980

gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat     2040

gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc     2100

ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc     2160

atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc     2220

ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc     2280

caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat     2340

ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag     2400

ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag     2460

atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt     2520

gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga     2580

ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg     2640

aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc     2700

agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat     2760

gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg     2820

gaaaatgaag atcgccgtag cgcttctctg cacctgccca agttaagcat caccggcacg     2880

tacgacctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct     2940

gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct     3000

gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata     3060

cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa     3120

caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaagagcag     3180

aagctgatca gcgaggagga cctgtagcct gcaggcgccg gcgaccggtg ctagccctgg     3240

aggcttgctg aaggctgtat gctgtaagct ggcagacctt ctgtcgtttt ggccactgac     3300

tgacgacaga agctgccagc ttacaggaca caaggcctgt tactagcact cacatggaac     3360

aaatggccac cggtatgcat cctggaggct tgctgaaggc tgtatgctga atgtaagctg     3420

gcagaccttc gttttggcca ctgactgacg aaggtctcag cttacattca ggacacaagg     3480

cctgttacta gcactcacat ggaacaaatg gccgctagct cgcgacctgg aggcttgctg     3540

aaggctgtat gctgataggt tccagtaatg gacaggtttt ggccactgac tgacctgtcc     3600

atctggaacc tatcaggaca caaggcctgt tactagcact cacatggaac aaatggcctc     3660

gcgatgcatc tagagcggcc gcggggatcc agacatgata agatacattg atgagtttgg     3720

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     3780

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     3840

ttttatgttt caggttcagg gggaggtgtg ggaggttttt tagtcgacct cgagcagtgt     3900

ggttttgcaa gaggaagcaa aaagcctctc cacccaggcc tggaatgttt ccacccaagt     3960

cgaaggcagt gtggttttgc aagaggaagc aaaaagcctc tccacccagg cctggaatgt     4020

ttccacccaa tgtcgagcaa ccccgcccag cgtcttgtca ttggcgaatt cgaacacgca     4080

gatgcagtcg gggcggcgcg gtcccaggtc cacttcgcat attaaggtga cgcgtgtggc     4140

ctcgaacacc gagcgaccct gcagccaata tgggatcggc cattgaacaa gatggattgc     4200

acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga     4260

caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt     4320

ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat     4380

cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg     4440

gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg     4500

ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc     4560

cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga     4620

tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag     4680

ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc     4740

atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg     4800

actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata     4860

ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg     4920

ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgaggggatc     4980

cgtcgactag agctcgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg     5040

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     5100

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     5160

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggaga     5220

gatctaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     5280

tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag     5340

cgagcgagcg cgcagagagg gagtggccaa cccccccccc cccccccctg cagccctgca     5400

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     5460

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     5520

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     5580

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     5640

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     5700

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     5760

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     5820

ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     5880

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     5940

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     6000

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     6060

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     6120

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     6180

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     6240

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     6300

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     6360

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     6420

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     6480

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg     6540

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag     6600

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt     6660

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt     6720

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt     6780

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt     6840

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct     6900

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt     6960

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac     7020

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa     7080

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     7140

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     7200

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     7260

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     7320

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     7380

tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag     7440

gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc     7500

ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc     7560

gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt     7620

actgagagtg caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg     7680

catcaggaaa ttgtaaacgt taatattttg ttaaaattcg cgttaaattt ttgttaaatc     7740

agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag     7800

accgagatag ggttgagtgt tgttccagtt tggaacaaga gtccactatt aaagaacgtg     7860

gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg atggcccact acgtgaacca     7920

tcaccctaat caagtttttt ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa     7980

gggagccccc gatttagagc ttgacgggga aagccggcga acgtggcgag aaaggaaggg     8040

aagaaagcga aaggagcggg cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta     8100

accaccacac ccgccgcgct taatgcgccg ctacagggcg cgtcgcgcca ttcgccattc     8160

aggctacgca actgttggga agggcgatcg gtgcgggcct cttcgctatt acgccaggct     8220

gca                                                                   8223


<210>  28
<211>  8360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Double-6XmiR-CB-AAT


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  enhancer
<222>  (182)..(548)
<223>  Enhancer

<220>
<221>  promoter
<222>  (549)..(1482)
<223>  Chicken beta actin promoter

<220>
<221>  Intron
<222>  (826)..(1482)
<223>  Intron

<220>
<221>  misc_feature
<222>  (1503)..(1529)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1530)..(1550)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (1570)..(1588)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1593)..(1633)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1646)..(1674)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1675)..(1695)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (1715)..(1733)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1738)..(1778)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1791)..(1819)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (1820)..(1840)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (1860)..(1878)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (1883)..(1923)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (1936)..(2035)
<223>  Globin

<220>
<221>  gene
<222>  (2058)..(3311)
<223>  Hardened alpha-1 antitrypsin (AAT)

<220>
<221>  misc_signal
<222>  (3312)..(3341)
<223>  Cmyc-tag

<220>
<221>  misc_feature
<222>  (3374)..(3401)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3402)..(3422)
<223>  Antisense 901

<220>
<221>  misc_feature
<222>  (3442)..(3460)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3465)..(3505)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (3518)..(3546)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3547)..(3567)
<223>  Antisense 914

<220>
<221>  misc_feature
<222>  (3587)..(3605)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3610)..(3650)
<223>  3' miR

<220>
<221>  misc_feature
<222>  (3663)..(3691)
<223>  5' miR

<220>
<221>  misc_feature
<222>  (3692)..(3712)
<223>  Antisense 943

<220>
<221>  misc_feature
<222>  (3732)..(3750)
<223>  Sense delta 2

<220>
<221>  misc_feature
<222>  (3755)..(3795)
<223>  3' miR

<220>
<221>  polyA_signal
<222>  (3814)..(4026)
<223>  polyA tail

<220>
<221>  promoter
<222>  (4167)..(4295)
<223>  thymidine kinase promoter (Tkp)

<220>
<221>  gene
<222>  (4307)..(5110)
<223>  Neomycin resistance gene

<220>
<221>  misc_feature
<222>  (5363)..(5508)
<223>  Inverted terminal repeats (ITR)

<220>
<221>  gene
<222>  (6528)..(7388)
<223>  Ampicillin resistance gene (complement)

<400>  28
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagggc cctttgtgcg ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg     1080

tggggagcgc cgcgtgcggc ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc     1140

ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg     1200

gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg     1260

agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc cctccccgag     1320

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     1380

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     1440

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcgac cggtgctagc     1500

cctggaggct tgctgaaggc tgtatgctgt aagctggcag accttctgtc gttttggcca     1560

ctgactgacg acagaagctg ccagcttaca ggacacaagg cctgttacta gcactcacat     1620

ggaacaaatg gccaccggta tgcatcctgg aggcttgctg aaggctgtat gctgaatgta     1680

agctggcaga ccttcgtttt ggccactgac tgacgaaggt ctcagcttac attcaggaca     1740

caaggcctgt tactagcact cacatggaac aaatggccgc tagctcgcga cctggaggct     1800

tgctgaaggc tgtatgctga taggttccag taatggacag gttttggcca ctgactgacc     1860

tgtccatctg gaacctatca ggacacaagg cctgttacta gcactcacat ggaacaaatg     1920

gcctcgcgat gcatctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca     1980

gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattcctcga     2040

agatctaggc ctgcaggatg ccgtcttctg tctcgtgggg catcctcctg ctggcaggcc     2100

tgtgctgcct ggtccctgtc tccctggctg aggatcccca gggagatgct gcccagaaga     2160

cagatacatc ccaccatgat caggatcacc caaccttcaa caagatcacc cccaacctgg     2220

ctgagttcgc cttcagccta taccgccagc tggcacacca gtccaacagc accaatatct     2280

tcttctcccc agtgagcatc gctacagcct ttgcaatgct ctccctgggg accaaggctg     2340

acactcacga tgaaatcctg gagggcctga atttcaacct cacggagatt ccggaggctc     2400

agatccatga aggcttccag gaactcctcc gtaccctcaa ccagccagac agccagctcc     2460

agctgaccac cggcaatggc ctgttcctca gcgagggcct gaagctagtg gataagtttt     2520

tggaggatgt taaaaagttg taccactcag aagccttcac tgtcaacttc ggggacaccg     2580

aagaggccaa gaaacagatc aacgattacg tggagaaggg tactcaaggg aaaattgtgg     2640

atttggtcaa ggagcttgac agagacacag tttttgctct ggtgaattac atcttcttta     2700

aaggcaaatg ggagagaccc tttgaagtca aggacaccga ggaagaggac ttccacgtgg     2760

accaggtgac caccgtgaag gtgcctatga tgaagcgttt aggcatgttt aacatccagc     2820

actgtaagaa gctgtccagc tgggtgctgc tgatgaaata cctgggcaat gccaccgcca     2880

tcttcttcct gcctgatgag gggaaactac agcacctgga aaatgaactc acccacgata     2940

tcatcaccaa gttcctggaa aatgaagatc gccgtagcgc ttctctgcac ctgcccaagt     3000

taagcatcac cggcacgtac gacctgaaga gcgtcctggg tcaactgggc atcactaagg     3060

tcttcagcaa tggggctgac ctctccgggg tcacagagga ggcacccctg aagctctcca     3120

aggccgtgca taaggctgtg ctgaccatcg acgagaaagg gactgaagct gctggggcca     3180

tgtttttaga ggccataccc atgtctatcc cccccgaggt caagttcaac aaaccctttg     3240

tcttcttaat gattgaacaa aataccaagt ctcccctctt catgggaaaa gtggtgaatc     3300

ccacccaaaa agagcagaag ctgatcagcg aggaggacct gtagcctgca ggcgccggcg     3360

accggtgcta gccctggagg cttgctgaag gctgtatgct gtaagctggc agaccttctg     3420

tcgttttggc cactgactga cgacagaagc tgccagctta caggacacaa ggcctgttac     3480

tagcactcac atggaacaaa tggccaccgg tatgcatcct ggaggcttgc tgaaggctgt     3540

atgctgaatg taagctggca gaccttcgtt ttggccactg actgacgaag gtctcagctt     3600

acattcagga cacaaggcct gttactagca ctcacatgga acaaatggcc gctagctcgc     3660

gacctggagg cttgctgaag gctgtatgct gataggttcc agtaatggac aggttttggc     3720

cactgactga cctgtccatc tggaacctat caggacacaa ggcctgttac tagcactcac     3780

atggaacaaa tggcctcgcg atgcatctag agcggccgcg gggatccaga catgataaga     3840

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     3900

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     3960

aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttag     4020

tcgacctcga gcagtgtggt tttgcaagag gaagcaaaaa gcctctccac ccaggcctgg     4080

aatgtttcca cccaagtcga aggcagtgtg gttttgcaag aggaagcaaa aagcctctcc     4140

acccaggcct ggaatgtttc cacccaatgt cgagcaaccc cgcccagcgt cttgtcattg     4200

gcgaattcga acacgcagat gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt     4260

aaggtgacgc gtgtggcctc gaacaccgag cgaccctgca gccaatatgg gatcggccat     4320

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     4380

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     4440

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga     4500

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     4560

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     4620

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     4680

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     4740

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     4800

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga     4860

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg     4920

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc     4980

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt     5040

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga     5100

gttcttctga ggggatccgt cgactagagc tcgctgatca gcctcgactg tgccttctag     5160

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     5220

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     5280

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     5340

caggcatgct ggggagagat ctaggaaccc ctagtgatgg agttggccac tccctctctg     5400

cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt     5460

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaaccc cccccccccc     5520

ccccctgcag ccctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt     5580

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga     5640

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca     5700

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     5760

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     5820

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     5880

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     5940

tcgggaagcg tggcgctttc tcaatgctca cgctgtaggt atctcagttc ggtgtaggtc     6000

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     6060

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     6120

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     6180

tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag     6240

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     6300

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     6360

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     6420

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     6480

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     6540

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     6600

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     6660

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     6720

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     6780

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     6840

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     6900

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     6960

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     7020

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     7080

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     7140

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     7200

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     7260

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     7320

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     7380

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     7440

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     7500

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     7560

aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc     7620

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     7680

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct taactatgcg     7740

gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc     7800

gtaaggagaa aataccgcat caggaaattg taaacgttaa tattttgtta aaattcgcgt     7860

taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc aaaatccctt     7920

ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg aacaagagtc     7980

cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat cagggcgatg     8040

gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc cgtaaagcac     8100

taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag ccggcgaacg     8160

tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg gcaagtgtag     8220

cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta cagggcgcgt     8280

cgcgccattc gccattcagg ctacgcaact gttgggaagg gcgatcggtg cgggcctctt     8340

cgctattacg ccaggctgca                                                 8360


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for PIM and PIZ

<400>  29
ccaaggccgt gcataagg                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PIM and PIZ

<400>  30
ggccccagca gcttcagt                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe for PIZ (mutant AAT)


<220>
<221>  misc_signal
<222>  (1)..(1)
<223>  6FAM probe molecule

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_signal
<222>  (18)..(18)
<223>  MGBNFQ probe molecule

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  31
nctgaccatc gacaagan                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe for PIM (wild-type AAT)


<220>
<221>  misc_signal
<222>  (1)..(1)
<223>  6FAM probe molecule

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_signal
<222>  (18)..(18)
<223>  MGBNFQ probe molecule

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  32
nctgaccatc gacgagan                                                     18


