                         SEQUENCE LISTING

<110>  BASF SE
 
<120>  Synthetic phytase variants

<130>  PF 72233

<140>  PCT/US
<141>  
<150>  61/477645  (US Provisional Application)
       11163453.1 (EP Priority Application)
<151>  April 21, 2011
       April 21, 2011
<160>  26    

<170>  PatentIn version 3.4

<210>  1
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  1
gayccnytnt tycaycc                                                    17


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<400>  2
ggngtrttrt cnggytg                                                    17


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  3
gcdatrttng trtcrtg                                                    17


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or t

<400>  4
wcagntgwtn gtnctg                                                     16


<210>  5
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
cttcgagagc cactttatta ccgtcg                                          26


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
ccaatgttgt gctgctgaca atagg                                           25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
ccgaactcat cagcgctaaa gatgc                                           25


<210>  8
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  8
cawcgwcnga sasgaa                                                     16


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
cgcagtttga cttgatgtcg cgcacg                                          26


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
gtcgcgcacg ccctatatcg ccaagc                                          26


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
ctgcaaacca tcgcacacgc actgg                                           25


<210>  12
<211>  1341
<212>  DNA
<213>  Hafnia sp.


<220>
<221>  sig_peptide
<222>  (1)..(99)

<400>  12
atgacaatct ctctgtttaa ccgtaataaa cccgctattg cacagcgtat tttatgtcct     60

ctgatcgtgg ctttattctc aggtttaccg gcatacgcca gtgataccgc ccctgctggg    120

ttccagttgg aaaaggttgt tatcctaagc agacatggcg tacgcgcgcc aaccaaaatg    180

acacaaacga tgcgcaacgt cacacctcac cagtggcctg aatggccggt aaaactcggc    240

tatatcacgc cccgcggtga acatctgatt agcctgatgg gcggttttta tcgagagcgc    300

tttcagcaac aaggcttatt acctaaggat aactgtccta caccagatgc cgtgtatgtt    360

tgggcagacg tcgatcaacg cacacgtaaa accggcgagg ccttcttagc gggtcttgct    420

ccccagtgtg atttagcgat ccaccatcag caaaacattc agcaggccga tccgctgttc    480

catcctgtga aagccggtat ctgttcgatg gataaatcac aggcacacgc cgccgttgaa    540

aagcaggcag gcacaccgat tgagacgctc aatcaacgct atcaagcatc tttagcgctg    600

atgagttcgg tactcgattt tccaaaatcc ccctattgtc agcagcacaa cattggcaaa    660

ctctgcgatt tttcacaggc gatgcctagc aggctggcga taaatgacga cggtaataaa    720

gtggctctcg aaggtgccgt gggactttca tcgacgttgg ctgaaatttt cctgctggaa    780

cacgctcagg gaatgcctaa agtggcttgg gggaatattc acactgagca gcaatgggac    840

tctctgttaa aattgcataa tgcgcagttt gacttgatgt cgcgcacgcc ctatatcgcc    900

aagcataacg gtactccact gctgcaaacc atcgcacacg cactgggttc caatatcgcg    960

agtcgcccac tgccggatat ttcgccagac aataagatcc tgtttattgc cggtcacgac   1020

accaatattg ccaatatttc tggcatgcta gggatgacat ggacacttcc gggacagcca   1080

gataacacgc ctccgggcgg ggctttagtg tttgaacgtt gggtagataa cgcggggaaa   1140

ccgtatgtta gcgtgaatat ggtgtatcaa acactggcac agttgcacga ccagacgccg   1200

ctaacgttgc agcatcctgc gggcagcgta cgactaaaca taccgggttg cagcgatcaa   1260

acgcccgatg gctattgccc gctctccacc ttcagccgtt tagtcaacca cagcgttgag   1320

cctgcgtgcc agcttcctta a                                             1341


<210>  13
<211>  446
<212>  PRT
<213>  Hafnia sp.


<220>
<221>  SIGNAL
<222>  (1)..(33)

<400>  13

Met Thr Ile Ser Leu Phe Asn Arg Asn Lys Pro Ala Ile Ala Gln Arg 
1               5                   10                  15      


Ile Leu Cys Pro Leu Ile Val Ala Leu Phe Ser Gly Leu Pro Ala Tyr 
            20                  25                  30          


Ala Ser Asp Thr Ala Pro Ala Gly Phe Gln Leu Glu Lys Val Val Ile 
        35                  40                  45              


Leu Ser Arg His Gly Val Arg Ala Pro Thr Lys Met Thr Gln Thr Met 
    50                  55                  60                  


Arg Asn Val Thr Pro His Gln Trp Pro Glu Trp Pro Val Lys Leu Gly 
65                  70                  75                  80  


Tyr Ile Thr Pro Arg Gly Glu His Leu Ile Ser Leu Met Gly Gly Phe 
                85                  90                  95      


Tyr Arg Glu Arg Phe Gln Gln Gln Gly Leu Leu Pro Lys Asp Asn Cys 
            100                 105                 110         


Pro Thr Pro Asp Ala Val Tyr Val Trp Ala Asp Val Asp Gln Arg Thr 
        115                 120                 125             


Arg Lys Thr Gly Glu Ala Phe Leu Ala Gly Leu Ala Pro Gln Cys Asp 
    130                 135                 140                 


Leu Ala Ile His His Gln Gln Asn Ile Gln Gln Ala Asp Pro Leu Phe 
145                 150                 155                 160 


His Pro Val Lys Ala Gly Ile Cys Ser Met Asp Lys Ser Gln Ala His 
                165                 170                 175     


Ala Ala Val Glu Lys Gln Ala Gly Thr Pro Ile Glu Thr Leu Asn Gln 
            180                 185                 190         


Arg Tyr Gln Ala Ser Leu Ala Leu Met Ser Ser Val Leu Asp Phe Pro 
        195                 200                 205             


Lys Ser Pro Tyr Cys Gln Gln His Asn Ile Gly Lys Leu Cys Asp Phe 
    210                 215                 220                 


Ser Gln Ala Met Pro Ser Arg Leu Ala Ile Asn Asp Asp Gly Asn Lys 
225                 230                 235                 240 


Val Ala Leu Glu Gly Ala Val Gly Leu Ser Ser Thr Leu Ala Glu Ile 
                245                 250                 255     


Phe Leu Leu Glu His Ala Gln Gly Met Pro Lys Val Ala Trp Gly Asn 
            260                 265                 270         


Ile His Thr Glu Gln Gln Trp Asp Ser Leu Leu Lys Leu His Asn Ala 
        275                 280                 285             


Gln Phe Asp Leu Met Ser Arg Thr Pro Tyr Ile Ala Lys His Asn Gly 
    290                 295                 300                 


Thr Pro Leu Leu Gln Thr Ile Ala His Ala Leu Gly Ser Asn Ile Ala 
305                 310                 315                 320 


Ser Arg Pro Leu Pro Asp Ile Ser Pro Asp Asn Lys Ile Leu Phe Ile 
                325                 330                 335     


Ala Gly His Asp Thr Asn Ile Ala Asn Ile Ser Gly Met Leu Gly Met 
            340                 345                 350         


Thr Trp Thr Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Ala 
        355                 360                 365             


Leu Val Phe Glu Arg Trp Val Asp Asn Ala Gly Lys Pro Tyr Val Ser 
    370                 375                 380                 


Val Asn Met Val Tyr Gln Thr Leu Ala Gln Leu His Asp Gln Thr Pro 
385                 390                 395                 400 


Leu Thr Leu Gln His Pro Ala Gly Ser Val Arg Leu Asn Ile Pro Gly 
                405                 410                 415     


Cys Ser Asp Gln Thr Pro Asp Gly Tyr Cys Pro Leu Ser Thr Phe Ser 
            420                 425                 430         


Arg Leu Val Asn His Ser Val Glu Pro Ala Cys Gln Leu Pro 
        435                 440                 445     


<210>  14
<211>  1074
<212>  DNA
<213>  Hafnia sp.

<400>  14
atgacaatct ctctgtttaa ccgtaataaa cccgctattg cacagcgtat tttatgtcct     60

ctgatcgtgg ctttattctc aggtttaccg gcatacgcca gtgataccgc ccctgctggg    120

ttccagttgg aaaaggttgt tatcctaagc agacatggcg tacgcgcgcc aaccaaaatg    180

acacaaacga tgcgcaacgt cacacctcac cagtggcctg aatggccggt aaaactcggc    240

tatatcacgc cccgcggtga acatctgatt agcctgatgg gcggttttta tcgagagcgc    300

tttcagcaac aaggcttatt acctaaggat aactgtccta caccagatgc cgtgtatgtt    360

tgggcagacg tcgatcaacg cacacgtaaa accggcgagg ccttcttagc gggtcttgct    420

ccccagtgtg atttagcgat ccaccatcag caaaacattc agcaggccga tccgctgttc    480

catcctgtga aagccggtat ctgttcgatg gataaatcac aggcacacgc cgccgttgaa    540

aagcaggcag gcacaccgat tgagacgctc aatcaacgct atcaagcatc tttagcgctg    600

atgagttcgg tactcgattt tccaaaatcc ccctattgtc agcagcacaa cattggcaaa    660

ctctgcgatt tttcacaggc gatgcctagc aggctggcga taaatgacga cggtaataaa    720

gtggctctcg aaggtgccgt gggactttca tcgacgttgg ctgaaatttt cctgctggaa    780

cacgctcagg gaatgcctaa agtggcttgg gggaatattc acactgagca gcaatgggac    840

tctctgttaa aattgcataa tgcgcagttt gacttgatgt cgcgcacgcc ctatatcgcc    900

aagcataacg gtactccact gctgcaaacc atcgcacacg cactgggttc caatatcgcg    960

agtcgcccac tgccggatat ttcgccagac aataagatcc tgtttattgc cggtcacgac   1020

accaatattg ccaatatttc tggcatgcta gggatgacat ggacacttcc ggga         1074


<210>  15
<211>  270
<212>  DNA
<213>  Yersinia mollaretii

<400>  15
cagcccgata acaccccgcc gggtgggggg ctggtgtttg aactatggca gaatccagat     60

aaccatcagc aatatgtcgc agttaagatg ttctatcaaa caatggatca gttacgaaat    120

agtgaaaagt tagacctgaa aagtcatcca gccggtattg ttcccattga gatcgaaggt    180

tgtgagaaca tcggtacaga caaactttgc cagcttgata ccttccaaaa gagagtggct    240

caggtgattg aacctgcatg ccatatttaa                                     270


<210>  16
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  sig_peptide
<222>  (1)..(99)

<400>  16
atgacaatct ctctgtttaa ccgtaataaa cccgctattg cacagcgtat tttatgtcct     60

ctgatcgtgg ctttattctc aggtttaccg gcatacgcca gtgataccgc ccctgctggg    120

ttccagttgg aaaaggttgt tatcctaagc agacatggcg tacgcgcgcc aaccaaaatg    180

acacaaacga tgcgcaacgt cacacctcac cagtggcctg aatggccggt aaaactcggc    240

tatatcacgc cccgcggtga acatctgatt agcctgatgg gcggttttta tcgagagcgc    300

tttcagcaac aaggcttatt acctaaggat aactgtccta caccagatgc cgtgtatgtt    360

tgggcagacg tcgatcaacg cacacgtaaa accggcgagg ccttcttagc gggtcttgct    420

ccccagtgtg atttagcgat ccaccatcag caaaacattc agcaggccga tccgctgttc    480

catcctgtga aagccggtat ctgttcgatg gataaatcac aggcacacgc cgccgttgaa    540

aagcaggcag gcacaccgat tgagacgctc aatcaacgct atcaagcatc tttagcgctg    600

atgagttcgg tactcgattt tccaaaatcc ccctattgtc agcagcacaa cattggcaaa    660

ctctgcgatt tttcacaggc gatgcctagc aggctggcga taaatgacga cggtaataaa    720

gtggctctcg aaggtgccgt gggactttca tcgacgttgg ctgaaatttt cctgctggaa    780

cacgctcagg gaatgcctaa agtggcttgg gggaatattc acactgagca gcaatgggac    840

tctctgttaa aattgcataa tgcgcagttt gacttgatgt cgcgcacgcc ctatatcgcc    900

aagcataacg gtactccact gctgcaaacc atcgcacacg cactgggttc caatatcgcg    960

agtcgcccac tgccggatat ttcgccagac aataagatcc tgtttattgc cggtcacgac   1020

accaatattg ccaatatttc tggcatgcta gggatgacat ggacacttcc gggacagccc   1080

gataacaccc cgccgggtgg ggggctggtg tttgaactat ggcagaatcc agataaccat   1140

cagcaatatg tcgcagttaa gatgttctat caaacaatgg atcagttacg aaatagtgaa   1200

aagttagacc tgaaaagtca tccagccggt attgttccca ttgagatcga aggttgtgag   1260

aacatcggta cagacaaact ttgccagctt gataccttcc aaaagagagt ggctcaggtg   1320

attgaacctg catgccatat ttaa                                          1344


<210>  17
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  SIGNAL
<222>  (1)..(33)

<400>  17

Met Thr Ile Ser Leu Phe Asn Arg Asn Lys Pro Ala Ile Ala Gln Arg 
1               5                   10                  15      


Ile Leu Cys Pro Leu Ile Val Ala Leu Phe Ser Gly Leu Pro Ala Tyr 
            20                  25                  30          


Ala Ser Asp Thr Ala Pro Ala Gly Phe Gln Leu Glu Lys Val Val Ile 
        35                  40                  45              


Leu Ser Arg His Gly Val Arg Ala Pro Thr Lys Met Thr Gln Thr Met 
    50                  55                  60                  


Arg Asn Val Thr Pro His Gln Trp Pro Glu Trp Pro Val Lys Leu Gly 
65                  70                  75                  80  


Tyr Ile Thr Pro Arg Gly Glu His Leu Ile Ser Leu Met Gly Gly Phe 
                85                  90                  95      


Tyr Arg Glu Arg Phe Gln Gln Gln Gly Leu Leu Pro Lys Asp Asn Cys 
            100                 105                 110         


Pro Thr Pro Asp Ala Val Tyr Val Trp Ala Asp Val Asp Gln Arg Thr 
        115                 120                 125             


Arg Lys Thr Gly Glu Ala Phe Leu Ala Gly Leu Ala Pro Gln Cys Asp 
    130                 135                 140                 


Leu Ala Ile His His Gln Gln Asn Ile Gln Gln Ala Asp Pro Leu Phe 
145                 150                 155                 160 


His Pro Val Lys Ala Gly Ile Cys Ser Met Asp Lys Ser Gln Ala His 
                165                 170                 175     


Ala Ala Val Glu Lys Gln Ala Gly Thr Pro Ile Glu Thr Leu Asn Gln 
            180                 185                 190         


Arg Tyr Gln Ala Ser Leu Ala Leu Met Ser Ser Val Leu Asp Phe Pro 
        195                 200                 205             


Lys Ser Pro Tyr Cys Gln Gln His Asn Ile Gly Lys Leu Cys Asp Phe 
    210                 215                 220                 


Ser Gln Ala Met Pro Ser Arg Leu Ala Ile Asn Asp Asp Gly Asn Lys 
225                 230                 235                 240 


Val Ala Leu Glu Gly Ala Val Gly Leu Ser Ser Thr Leu Ala Glu Ile 
                245                 250                 255     


Phe Leu Leu Glu His Ala Gln Gly Met Pro Lys Val Ala Trp Gly Asn 
            260                 265                 270         


Ile His Thr Glu Gln Gln Trp Asp Ser Leu Leu Lys Leu His Asn Ala 
        275                 280                 285             


Gln Phe Asp Leu Met Ser Arg Thr Pro Tyr Ile Ala Lys His Asn Gly 
    290                 295                 300                 


Thr Pro Leu Leu Gln Thr Ile Ala His Ala Leu Gly Ser Asn Ile Ala 
305                 310                 315                 320 


Ser Arg Pro Leu Pro Asp Ile Ser Pro Asp Asn Lys Ile Leu Phe Ile 
                325                 330                 335     


Ala Gly His Asp Thr Asn Ile Ala Asn Ile Ser Gly Met Leu Gly Met 
            340                 345                 350         


Thr Trp Thr Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly 
        355                 360                 365             


Leu Val Phe Glu Leu Trp Gln Asn Pro Asp Asn His Gln Gln Tyr Val 
    370                 375                 380                 


Ala Val Lys Met Phe Tyr Gln Thr Met Asp Gln Leu Arg Asn Ser Glu 
385                 390                 395                 400 


Lys Leu Asp Leu Lys Ser His Pro Ala Gly Ile Val Pro Ile Glu Ile 
                405                 410                 415     


Glu Gly Cys Glu Asn Ile Gly Thr Asp Lys Leu Cys Gln Leu Asp Thr 
            420                 425                 430         


Phe Gln Lys Arg Val Ala Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440                 445         


<210>  18
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric protein

<400>  18

Ser Asp Thr Ala Pro Ala Gly Phe Gln Leu Glu Lys Val Val Ile Leu 
1               5                   10                  15      


Ser Arg His Gly Val Arg Ala Pro Thr Lys Met Thr Gln Thr Met Arg 
            20                  25                  30          


Asn Val Thr Pro His Gln Trp Pro Glu Trp Pro Val Lys Leu Gly Tyr 
        35                  40                  45              


Ile Thr Pro Arg Gly Glu His Leu Ile Ser Leu Met Gly Gly Phe Tyr 
    50                  55                  60                  


Arg Glu Arg Phe Gln Gln Gln Gly Leu Leu Pro Lys Asp Asn Cys Pro 
65                  70                  75                  80  


Thr Pro Asp Ala Val Tyr Val Trp Ala Asp Val Asp Gln Arg Thr Arg 
                85                  90                  95      


Lys Thr Gly Glu Ala Phe Leu Ala Gly Leu Ala Pro Gln Cys Asp Leu 
            100                 105                 110         


Ala Ile His His Gln Gln Asn Ile Gln Gln Ala Asp Pro Leu Phe His 
        115                 120                 125             


Pro Val Lys Ala Gly Ile Cys Ser Met Asp Lys Ser Gln Ala His Ala 
    130                 135                 140                 


Ala Val Glu Lys Gln Ala Gly Thr Pro Ile Glu Thr Leu Asn Gln Arg 
145                 150                 155                 160 


Tyr Gln Ala Ser Leu Ala Leu Met Ser Ser Val Leu Asp Phe Pro Lys 
                165                 170                 175     


Ser Pro Tyr Cys Gln Gln His Asn Ile Gly Lys Leu Cys Asp Phe Ser 
            180                 185                 190         


Gln Ala Met Pro Ser Arg Leu Ala Ile Asn Asp Asp Gly Asn Lys Val 
        195                 200                 205             


Ala Leu Glu Gly Ala Val Gly Leu Ser Ser Thr Leu Ala Glu Ile Phe 
    210                 215                 220                 


Leu Leu Glu His Ala Gln Gly Met Pro Lys Val Ala Trp Gly Asn Ile 
225                 230                 235                 240 


His Thr Glu Gln Gln Trp Asp Ser Leu Leu Lys Leu His Asn Ala Gln 
                245                 250                 255     


Phe Asp Leu Met Ser Arg Thr Pro Tyr Ile Ala Lys His Asn Gly Thr 
            260                 265                 270         


Pro Leu Leu Gln Thr Ile Ala His Ala Leu Gly Ser Asn Ile Ala Ser 
        275                 280                 285             


Arg Pro Leu Pro Asp Ile Ser Pro Asp Asn Lys Ile Leu Phe Ile Ala 
    290                 295                 300                 


Gly His Asp Thr Asn Ile Ala Asn Ile Ser Gly Met Leu Gly Met Thr 
305                 310                 315                 320 


Trp Thr Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu 
                325                 330                 335     


Val Phe Glu Leu Trp Gln Asn Pro Asp Asn His Gln Gln Tyr Val Ala 
            340                 345                 350         


Val Lys Met Phe Tyr Gln Thr Met Asp Gln Leu Arg Asn Ser Glu Lys 
        355                 360                 365             


Leu Asp Leu Lys Ser His Pro Ala Gly Ile Val Pro Ile Glu Ile Glu 
    370                 375                 380                 


Gly Cys Glu Asn Ile Gly Thr Asp Lys Leu Cys Gln Leu Asp Thr Phe 
385                 390                 395                 400 


Gln Lys Arg Val Ala Gln Val Ile Glu Pro Ala Cys His Ile 
                405                 410                 


<210>  19
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19
agtgataccg cccctgctgg gttccagttg gaaaaggttg ttatcctaag cagacatggc     60

gtacgcgcgc caaccaaaat gacacaaacg atgcgcaacg tcacacctca ccagtggcct    120

gaatggccgg taaaactcgg ctatatcacg ccccgcggtg aacatctgat tagcctgatg    180

ggcggttttt atcgagagcg ctttcagcaa caaggcttat tacctaagga taactgtcct    240

acaccagatg ccgtgtatgt ttgggcagac gtcgatcaac gcacacgtaa aaccggcgag    300

gccttcttag cgggtcttgc tccccagtgt gatttagcga tccaccatca gcaaaacatt    360

cagcaggccg atccgctgtt ccatcctgtg aaagccggta tctgttcgat ggataaatca    420

caggcacacg ccgccgttga aaagcaggca ggcacaccga ttgagacgct caatcaacgc    480

tatcaagcat ctttagcgct gatgagttcg gtactcgatt ttccaaaatc cccctattgt    540

cagcagcaca acattggcaa actctgcgat ttttcacagg cgatgcctag caggctggcg    600

ataaatgacg acggtaataa agtggctctc gaaggtgccg tgggactttc atcgacgttg    660

gctgaaattt tcctgctgga acacgctcag ggaatgccta aagtggcttg ggggaatatt    720

cacactgagc agcaatggga ctctctgtta aaattgcata atgcgcagtt tgacttgatg    780

tcgcgcacgc cctatatcgc caagcataac ggtactccac tgctgcaaac catcgcacac    840

gcactgggtt ccaatatcgc gagtcgccca ctgccggata tttcgccaga caataagatc    900

ctgtttattg ccggtcacga caccaatatt gccaatattt ctggcatgct agggatgaca    960

tggacacttc cgggacagcc cgataacacc ccgccgggtg gggggctggt gtttgaacta   1020

tggcagaatc cagataacca tcagcaatat gtcgcagtta agatgttcta tcaaacaatg   1080

gatcagttac gaaatagtga aaagttagac ctgaaaagtc atccagccgg tattgttccc   1140

attgagatcg aaggttgtga gaacatcggt acagacaaac tttgccagct tgataccttc   1200

caaaagagag tggctcaggt gattgaacct gcatgccata tttaa                   1245


<210>  20
<211>  6729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20
agcttgcggc cgcactcgag caccaccacc accaccactg agatccggct gctaacaaag     60

cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactagca taaccccttg    120

gggcctctaa acgggtcttg aggggttttt tgctgaaagg aggaactata tccggattgg    180

cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag    240

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt    300

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt    360

ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg    420

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt    480

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt    540

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca    600

aaaatttaac gcgaatttta acaaaatatt aacgtttaca atttcaggtg gcacttttcg    660

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc    720

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag    780

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt    840

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt    900

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga    960

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat   1020

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga   1080

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag   1140

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg   1200

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg   1260

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgc   1320

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg   1380

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc   1440

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg   1500

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac   1560

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact   1620

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa   1680

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa   1740

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg   1800

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc   1860

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac   1920

tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca   1980

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt   2040

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc   2100

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg   2160

aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc   2220

cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac   2280

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct   2340

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc   2400

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt   2460

tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac   2520

cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg   2580

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc   2640

actctcagta caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc   2700

tacgtgactg ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac   2760

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca   2820

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat   2880

cagcgtggtc gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga   2940

gtttctccag aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt   3000

tttcctgttt ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga   3060

taccgatgaa acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt   3120

tactggaacg ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa   3180

tcactcaggg tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc   3240

agcagcatcc tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt   3300

ccagacttta cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg   3360

ttttgcagca gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag   3420

taaggcaacc ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc   3480

gtggggccgc catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac   3540

cagtgacgaa ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga   3600

tcatcgtcgc gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca   3660

cctgtcctac gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc   3720

cccgcgccca ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc   3780

ccggtgccta atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc   3840

agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg   3900

gtttgcgtat tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga   3960

ttgcccttca ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc   4020

agcaggcgaa aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg   4080

gtatcgtcgt atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg   4140

gcgcgcattg cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg   4200

ccctcattca gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc   4260

cgttccgcta tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc   4320

agacgcgccg agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat   4380

gcgaccagat gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg   4440

atgggtgtct ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc   4500

acagcaatgg catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc   4560

gcgagaagat tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac   4620

accaccacgc tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac   4680

ggcgcgtgca gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc   4740

agttgttgtg ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt   4800

tcccgcgttt tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa   4860

gagacaccgg catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg   4920

aattgactct cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg   4980

gtgtccggga tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag   5040

taggttgagg ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc   5100

caacagtccc ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag   5160

cccgaagtgg cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac   5220

cgcacctgtg gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc   5280

gatcccgcga aattaatacg actcactata ggggaattgt gagcggataa caattcccct   5340

ctagaaataa ttttgtttaa ctttaagaag gagatataca tatgatgaca atctctctgt   5400

ttaaccgtaa taaacccgct attgcacagc gtattttatg tcctctgatc gtggctttat   5460

tctcaggttt accggcatac gccagtgata ccgcccctgc tgggttccag ttggaaaagg   5520

ttgttatcct aagcagacat ggcgtacgcg cgccaaccaa aatgacacaa acgatgcgca   5580

acgtcacacc tcaccagtgg cctgaatggc cggtaaaact cggctatatc acgccccgcg   5640

gtgaacatct gattagcctg atgggcggtt tttatcgaga gcgctttcag caacaaggct   5700

tattacctaa ggataactgt cctacaccag atgccgtgta tgtttgggca gacgtcgatc   5760

aacgcacacg taaaaccggc gaggccttct tagcgggtct tgctccccag tgtgatttag   5820

cgatccacca tcagcaaaac attcagcagg ccgatccgct gttccatcct gtgaaagccg   5880

gtatctgttc gatggataaa tcacaggcac acgccgccgt tgaaaagcag gcaggcacac   5940

cgattgagac gctcaatcaa cgctatcaag catctttagc gctgatgagt tcggtactcg   6000

attttccaaa atccccctat tgtcagcagc acaacattgg caaactctgc gatttttcac   6060

aggcgatgcc tagcaggctg gcgataaatg acgacggtaa taaagtggct ctcgaaggtg   6120

ccgtgggact ttcatcgacg ttggctgaaa ttttcctgct ggaacacgct cagggaatgc   6180

ctaaagtggc ttgggggaat attcacactg agcagcaatg ggactctctg ttaaaattgc   6240

ataatgcgca gtttgacttg atgtcgcgca cgccctatat cgccaagcat aacggtactc   6300

cactgctgca aaccatcgca cacgcactgg gttccaatat cgcgagtcgc ccactgccgg   6360

atatttcgcc agacaataag atcctgttta ttgccggtca cgacaccaat attgccaata   6420

tttctggcat gctagggatg acatggacac ttccgggaca gcccgataac accccgccgg   6480

gtggggggct ggtgtttgaa ctatggcaga atccagataa ccatcagcaa tatgtcgcag   6540

ttaagatgtt ctatcaaaca atggatcagt tacgaaatag tgaaaagtta gacctgaaaa   6600

gtcatccagc cggtattgtt cccattgaga tcgaaggttg tgagaacatc ggtacagaca   6660

aactttgcca gcttgatacc ttccaaaaga gagtggctca ggtgattgaa cctgcatgcc   6720

atatttaaa                                                           6729


<210>  21
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
ctatggatcc gcatcatcat catcatcaca gtgataccgc ccctgc                    46


<210>  22
<211>  6738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22
gagatataca tatgaaatac ctgctgccga ccgctgctgc tggtctgctg ctcctcgctg     60

cccagccggc gatggccatg gatatcggaa ttaattcgga tccgcatcat catcatcatc    120

acagtgatac cgcccctgct gggttccagt tggaaaaggt tgttatccta agcagacatg    180

gcgtacgcgc gccaaccaaa atgacacaaa cgatgcgcaa cgtcacacct caccagtggc    240

ctgaatggcc ggtaaaactc ggctatatca cgccccgcgg tgaacatctg attagcctga    300

tgggcggttt ttatcgagag cgctttcagc aacaaggctt attacctaag gataactgtc    360

ctacaccaga tgccgtgtat gtttgggcag acgtcgatca acgcacacgt aaaaccggcg    420

aggccttctt agcgggtctt gctccccagt gtgatttagc gatccaccat cagcaaaaca    480

ttcagcaggc cgatccgctg ttccatcctg tgaaagccgg tatctgttcg atggataaat    540

cacaggcaca cgccgccgtt gaaaagcagg caggcacacc gattgagacg ctcaatcaac    600

gctatcaagc atctttagcg ctgatgagtt cggtactcga ttttccaaaa tccccctatt    660

gtcagcagca caacattggc aaactctgcg atttttcaca ggcgatgcct agcaggctgg    720

cgataaatga cgacggtaat aaagtggctc tcgaaggtgc cgtgggactt tcatcgacgt    780

tggctgaaat tttcctgctg gaacacgctc agggaatgcc taaagtggct tgggggaata    840

ttcacactga gcagcaatgg gactctctgt taaaattgca taatgcgcag tttgacttga    900

tgtcgcgcac gccctatatc gccaagcata acggtactcc actgctgcaa accatcgcac    960

acgcactggg ttccaatatc gcgagtcgcc cactgccgga tatttcgcca gacaataaga   1020

tcctgtttat tgccggtcac gacaccaata ttgccaatat ttctggcatg ctagggatga   1080

catggacact tccgggacag cccgataaca ccccgccggg tggggggctg gtgtttgaac   1140

tatggcagaa tccagataac catcagcaat atgtcgcagt taagatgttc tatcaaacaa   1200

tggatcagtt acgaaatagt gaaaagttag acctgaaaag tcatccagcc ggtattgttc   1260

ccattgagat cgaaggttgt gagaacatcg gtacagacaa actttgccag cttgatacct   1320

tccaaaagag agtggctcag gtgattgaac ctgcatgcca tatttaaaag cttgcggccg   1380

cactcgagca ccaccaccac caccactgag atccggctgc taacaaagcc cgaaaggaag   1440

ctgagttggc tgctgccacc gctgagcaat aactagcata accccttggg gcctctaaac   1500

gggtcttgag gggttttttg ctgaaaggag gaactatatc cggattggcg aatgggacgc   1560

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac   1620

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt   1680

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc   1740

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc   1800

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact   1860

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg   1920

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc   1980

gaattttaac aaaatattaa cgtttacaat ttcaggtggc acttttcggg gaaatgtgcg   2040

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca   2100

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt   2160

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga   2220

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga   2280

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat   2340

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca   2400

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt   2460

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac   2520

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct   2580

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga   2640

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac   2700

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat   2760

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg   2820

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc   2880

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc   2940

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg   3000

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta   3060

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg   3120

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga   3180

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt   3240

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag   3300

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa   3360

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag   3420

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca   3480

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac   3540

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa   3600

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc   3660

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg   3720

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc   3780

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc   3840

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag   3900

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc tgatgcggta   3960

ttttctcctt acgcatctgt gcggtatttc acaccgcata tatggtgcac tctcagtaca   4020

atctgctctg atgccgcata gttaagccag tatacactcc gctatcgcta cgtgactggg   4080

tcatggctgc gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc   4140

tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt   4200

tttcaccgtc atcaccgaaa cgcgcgaggc agctgcggta aagctcatca gcgtggtcgt   4260

gaagcgattc acagatgtct gcctgttcat ccgcgtccag ctcgttgagt ttctccagaa   4320

gcgttaatgt ctggcttctg ataaagcggg ccatgttaag ggcggttttt tcctgtttgg   4380

tcactgatgc ctccgtgtaa gggggatttc tgttcatggg ggtaatgata ccgatgaaac   4440

gagagaggat gctcacgata cgggttactg atgatgaaca tgcccggtta ctggaacgtt   4500

gtgagggtaa acaactggcg gtatggatgc ggcgggacca gagaaaaatc actcagggtc   4560

aatgccagcg cttcgttaat acagatgtag gtgttccaca gggtagccag cagcatcctg   4620

cgatgcagat ccggaacata atggtgcagg gcgctgactt ccgcgtttcc agactttacg   4680

aaacacggaa accgaagacc attcatgttg ttgctcaggt cgcagacgtt ttgcagcagc   4740

agtcgcttca cgttcgctcg cgtatcggtg attcattctg ctaaccagta aggcaacccc   4800

gccagcctag ccgggtcctc aacgacagga gcacgatcat gcgcacccgt ggggccgcca   4860

tgccggcgat aatggcctgc ttctcgccga aacgtttggt ggcgggacca gtgacgaagg   4920

cttgagcgag ggcgtgcaag attccgaata ccgcaagcga caggccgatc atcgtcgcgc   4980

tccagcgaaa gcggtcctcg ccgaaaatga cccagagcgc tgccggcacc tgtcctacga   5040

gttgcatgat aaagaagaca gtcataagtg cggcgacgat agtcatgccc cgcgcccacc   5100

ggaaggagct gactgggttg aaggctctca agggcatcgg tcgagatccc ggtgcctaat   5160

gagtgagcta acttacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc   5220

tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg   5280

ggcgccaggg tggtttttct tttcaccagt gagacgggca acagctgatt gcccttcacc   5340

gcctggccct gagagagttg cagcaagcgg tccacgctgg tttgccccag caggcgaaaa   5400

tcctgtttga tggtggttaa cggcgggata taacatgagc tgtcttcggt atcgtcgtat   5460

cccactaccg agatatccgc accaacgcgc agcccggact cggtaatggc gcgcattgcg   5520

cccagcgcca tctgatcgtt ggcaaccagc atcgcagtgg gaacgatgcc ctcattcagc   5580

atttgcatgg tttgttgaaa accggacatg gcactccagt cgccttcccg ttccgctatc   5640

ggctgaattt gattgcgagt gagatattta tgccagccag ccagacgcag acgcgccgag   5700

acagaactta atgggcccgc taacagcgcg atttgctggt gacccaatgc gaccagatgc   5760

tccacgccca gtcgcgtacc gtcttcatgg gagaaaataa tactgttgat gggtgtctgg   5820

tcagagacat caagaaataa cgccggaaca ttagtgcagg cagcttccac agcaatggca   5880

tcctggtcat ccagcggata gttaatgatc agcccactga cgcgttgcgc gagaagattg   5940

tgcaccgccg ctttacaggc ttcgacgccg cttcgttcta ccatcgacac caccacgctg   6000

gcacccagtt gatcggcgcg agatttaatc gccgcgacaa tttgcgacgg cgcgtgcagg   6060

gccagactgg aggtggcaac gccaatcagc aacgactgtt tgcccgccag ttgttgtgcc   6120

acgcggttgg gaatgtaatt cagctccgcc atcgccgctt ccactttttc ccgcgttttc   6180

gcagaaacgt ggctggcctg gttcaccacg cgggaaacgg tctgataaga gacaccggca   6240

tactctgcga catcgtataa cgttactggt ttcacattca ccaccctgaa ttgactctct   6300

tccgggcgct atcatgccat accgcgaaag gttttgcgcc attcgatggt gtccgggatc   6360

tcgacgctct cccttatgcg actcctgcat taggaagcag cccagtagta ggttgaggcc   6420

gttgagcacc gccgccgcaa ggaatggtgc atgcaaggag atggcgccca acagtccccc   6480

ggccacgggg cctgccacca tacccacgcc gaaacaagcg ctcatgagcc cgaagtggcg   6540

agcccgatct tccccatcgg tgatgtcggc gatataggcg ccagcaaccg cacctgtggc   6600

gccggtgatg ccggccacga tgcgtccggc gtagaggatc gagatctcga tcccgcgaaa   6660

ttaatacgac tcactatagg ggaattgtga gcggataaca attcccctct agaaataatt   6720

ttgtttaact ttaagaag                                                 6738


<210>  23
<211>  10331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23
aagcttgcat gagcatgtca cagtcgaatt ctggggtcac gcggtgcttg agggcgaata     60

cggctccatc ggtgagtaac ctctctctta ctaccacgga aacatcactg acgtaaccag    120

gacccggcgg cttatccatc atgggaaaca acacctacaa atccgccaga attctctcgg    180

aagaatataa cctctactac tccgtctggt gcgacggtga ccacgagctg tacgatctct    240

cagtaagtgc caaccggttc ccgccactat cgtaaaaaca aaaaatctaa caacaccaga    300

cggaccccta ccaaatgaac aacatctaca cccaacaaga caacatccac ctcctaagca    360

gacctctatc cagcgtgatt gatcgtatcg acgctctcct tctggttctg aaatcctgca    420

agggtaacac atgcatccag ccgtggcggg tcctccaccc cgacgggtcc gtagagagcc    480

tcaaagatgc actgcaggtg aaatacgatt ccttttacac caaccagccc aaggtgtcgt    540

attcagtatg tgaacccggg tacatcattg aggctgaggg gccccaggtc ggattgcagt    600

atagagatgg gctgagttgg gaggcgtgga cttgacgatt ccgtcaagta tgagtatggg    660

tacgaataat gagcgttatt gctatgtatt tttatagata gtttatttat atatcatgac    720

taaacttgag agccatggaa tcaatgaaat gacatggcga gtgtagatca cgatagtcat    780

agtagccgaa gtgggcggat agccaagaat aacaccagaa tcagataaca ggaacatcac    840

aaccgatcac accatagata atatccaaag aagtttaaat agccgagaca aagagaatag    900

agacaagata catggaacaa gaaaggtaca cccggtagat aaaccctggg acgggcccga    960

gtccttaccc atagatcaat cccacgggaa caaaaccaaa gtcaacaacc accaccacca   1020

ttaccacaac cgcatcaata gaaccggtga aaaatgacac catcgaatcc ttcaccctaa   1080

gtaaagccct gtacgttgca tatcgcttaa gcacaaaagt agtagaatag atatgagccc   1140

gcacgcgcgg ccaacgatcc aaactagccc tgacatcaaa gccagcggcg attgcgccat   1200

caagcccccg tctcacttca tagtggaatt gcgggtcacc tcactgattg actgtctgtc   1260

tagacacact cacccacgca tgctgtctgt gcccagaacg tggactttgg ctctgccgag   1320

ctagaggatc aaatataagt agattggatg taggcccgta ttttttttat ttcgtgtgac   1380

tcggagattt tatgcgttgt gttgttgggc ggaaaaagaa atatactttc tttttgttct   1440

tttctttttc tctctattgc ttgccttgga tatcccttgc atacggtcgg ttgctgattg   1500

actaagggtg ctgtcttgtg tcactgaact gctgctcaac ctctgtctgg tattcctgtt   1560

gtcgtgatgg tggggaaaca gttcgagttc gaggaccaga gggatggcat cgtgcctccc   1620

ttggaggaaa agaaggtcgt cgatgaggtc tataccgata atgatgttgc gtcggaggag   1680

attgtcaagg actgggatga taaggaggag ggcaagctgc ggaggaagtg agtcgtcact   1740

gttttcattc actgccatat aggttcaagc atatactgac tggtatatag gatcgatatc   1800

atcctcatcc ccattctcgc tctcgctttc ttcggcctcc agattgatcg cggcaatatc   1860

agcgcagctc ttacctccac tatcaccgaa gacctaggtg tcaccacgaa ccaaatcaat   1920

attggaaccc agttgctttc ggctggtatt gtcatcaccg agatcccgtc aaatattata   1980

cttcagcgca tcggtcccca ggtctggttg tcggcacagc tgatcgcttg gggtctggtt   2040

ggcacattcc aggcttttgt acagtcgtac ccggcgtatc tggccacgag gttgttgctg   2100

gggctgttgg agggagggtt tattcctggt ttgtctggtc gtgcgccttg gtctatggtg   2160

gtagcgctaa caatgggttt ggtacaggtg ccctgtacta tctctcgaca tggtataaac   2220

gtcctgagac gagtttccgg accactctgt tcttctatgg gcagatgttt gccggtgcga   2280

cctcgagcgg ccgcttcgag gattgcctga acattgacat tcggcgtccg gccgggacca   2340

ccgcggactc gaagctgcct gtgctggtct ggatctttgg cggaggcttt gaacttggtt   2400

caaaggcgat gtatgatggt acaacgatgg tatcatcgtc gatagacaag aacatgccta   2460

tcgtgtttgt agcaatgaat tatcgcgtgg gaggtttcgg gttcttgccc ggaaaggaga   2520

tcctggagga cgggtccgcg aacctagggc tcctggacca acgccttgcc ctgcagtggg   2580

ttgccgacaa catcgaggcc tttggtggag acccggacaa ggtgacgatt tggggagaat   2640

cagcaggagc catttccgtt tttgatcaga tgatcttgta cgacggaaac atcacttaca   2700

aggataagcc cttgttccgg ggggccatca tggactccgg tagtgttgtt cccgcagacc   2760

ccgtcgatgg ggtcaaggga cagcaagtat atgatgcggt agtggaatct gcaggctgtt   2820

cctcttctaa cgacacccta gcttgtctgc gtgaactaga ctacaccgac ttcctcaatg   2880

cggcaaactc cgtgccaggc attttaagct accattctgt ggcgttatca tatgtgcctc   2940

gaccggacgg gacggcgttg tcggcatcac cggacgtttt gggcaaagca gggaaatatg   3000

ctcgggtccc gttcatcgtg ggcgaccaag aggatgaggg gaccttattc gccttgtttc   3060

agtccaacat tacgacgatc gacgaggtgg tcgactacct ggcctcatac ttcttctatg   3120

acgctagccg agagcagctt gaagaactag tggccctgta cccagacacc accacgtacg   3180

ggtctccgtt caggacaggc gcggccaaca actggtatcc gcaatttaag cgattggccg   3240

ccattctcgg cgacttggtc ttcaccatta cccggcgggc attcctctcg tatgcagagg   3300

aaatctcccc tgatcttccg aactggtcgt acctggcgac ctatgactat ggcaccccag   3360

ttctggggac cttccacgga agtgacctgc tgcaggtgtt ctatgggatc aagccaaact   3420

atgcagctag ttctagccac acgtactatc tgagctttgt gtatacgctg gatccgaact   3480

ccaaccgggg ggagtacatt gagtggccgc agtggaagga atcgcggcag ttgatgaatt   3540

tcggagcgaa cgacgccagt ctccttacgg atgatttccg caacgggaca tatgagttca   3600

tcctgcagaa taccgcggcg ttccacatct gatgccattg gcggaggggt ccggacggtc   3660

aggaacttag ccttatgaga tgaatgatgg acgtgtctgg cctcggaaaa ggatatatgg   3720

ggatcatgat agtactagcc atattaatga agggcatata ccacgcgttg gacctgcgtt   3780

atagcttccc gttagttata gtaccatcgt tataccagcc aatcaagtca ccacgcacga   3840

ccggggacgg cgaatccccg ggaattgaaa gaaattgcat cccaggccag tgaggccagc   3900

gattggccac ctctccaagg cacagggcca ttctgcagcg ctggtggatt catcgcaatt   3960

tcccccggcc cggcccgaca ccgctatagg ctggttctcc cacaccatcg gagattcgtc   4020

gcctaatgtc tcgtccgttc acaagctgaa gagcttgaag tggcgagatg tctctgcagg   4080

aattcaagct agatgctaag cgatattgca tggcaatatg tgttgatgca tgtgcttctt   4140

ccttcagctt cccctcgtgc agatgaggtt tggctataaa ttgaagtggt tggtcggggt   4200

tccgtgaggg gctgaagtgc ttcctccctt ttagacgcaa ctgagagcct gagcttcatc   4260

cccagcatca ttacacctca gcaatgggcg tctctgctgt tctacttcct ttgtatctcc   4320

tgtctgggta tgctaagcac cacaatcaaa gtctaataag gaccctccct tccgagggcc   4380

cctgaagctc ggactgtgtg ggactactga tcgctgacta tctgtgcaga gtcacctccg   4440

gactggcagt ccccagtgat accgcccctg ctgggttcca gttggaaaag gttgttatcc   4500

taagcagaca tggcgtacgc gcgccaacca aaatgacaca aacgatgcgc aacgtcacac   4560

ctcaccagtg gcctgaatgg ccggtaaaac tcggctatat cacgccccgc ggtgaacatc   4620

tgattagcct gatgggcggt ttttatcgag agcgctttca gcaacaaggc ttattaccta   4680

aggataactg tcctacacca gatgccgtgt atgtttgggc agacgtcgat caacgcacac   4740

gtaaaaccgg cgaggccttc ttagcgggtc ttgctcccca gtgtgattta gcgatccacc   4800

atcagcaaaa cattcagcag gccgatccgc tgttccatcc tgtgaaagcc ggtatctgtt   4860

cgatggataa atcacaggca cacgccgccg ttgaaaagca ggcaggcaca ccgattgaga   4920

cgctcaatca acgctatcaa gcatctttag cgctgatgag ttcggtactc gattttccaa   4980

aatcccccta ttgtcagcag cacaacattg gcaaactctg cgatttttca caggcgatgc   5040

ctagcaggct ggcgataaat gacgacggta ataaagtggc tctcgaaggt gccgtgggac   5100

tttcatcgac gttggctgaa attttcctgc tggaacacgc tcagggaatg cctaaagtgg   5160

cttgggggaa tattcacact gagcagcaat gggactctct gttaaaattg cataatgcgc   5220

agtttgactt gatgtcgcgc acgccctata tcgccaagca taacggtact ccactgctgc   5280

aaaccatcgc acacgcactg ggttccaata tcgcgagtcg cccactgccg gatatttcgc   5340

cagacaataa gatcctgttt attgccggtc acgacaccaa tattgccaat atttctggca   5400

tgctagggat gacatggaca cttccgggac agcccgataa caccccgccg ggtggggggc   5460

tggtgtttga actatggcag aatccagata accatcagca atatgtcgca gttaagatgt   5520

tctatcaaac aatggatcag ttacgaaata gtgaaaagtt agacctgaaa agtcatccag   5580

ccggtattgt tcccattgag atcgaaggtt gtgagaacat cggtacagac aaactttgcc   5640

agcttgatac cttccaaaag agagtggctc aggtgattga acctgcatgc catatttaga   5700

caatcaatcc atttcgctat agttaaagga tggggatgag ggcaattggt tatatgatca   5760

tgtatgtagt gggtgtgcat aatagtagtg aaatggaagc caagtcatgt gattgtaatc   5820

gaccgacgga attgaggata tccggaaata cagacaccgt gaaagccatg gtctttcctt   5880

cgtgtagaag accagacaga cagtccctga tttaccctgc acaaagcact agaaaattag   5940

cattccatcc ttctctgctt gctctgctga tatcactgtc attcaatgca tagccatgag   6000

ctcatcttag atccaagcac gtaattccat agccgaggtc cacagtggag cagcaacatt   6060

ccccatcatt gctttcccca ggggcctccc aacgactaaa tcaagagtat atctctaccg   6120

tccaatagat cgtcttcgct tcaaaatctt tgacaattcc aagagggtcc ccatccatca   6180

aacccagttc aataatagcc gagatgcatg gtggagtcaa ttaggcagta ttgctggaat   6240

gtcggggcca gttccgggtg gtcattggcc gcctgtgatg ccatctgcca ctaaatccga   6300

tcattgatcc accgcccacg agggcgtctt tgctttttgc gcggcgtcca ggttcaactc   6360

tctctgcagc tccagtccaa cgctgactga ctagtttacc tactggtctg atcggctcca   6420

tcagagctat ggcgttatcc cgtgccgttg ctgcgcaatc gctatcttga tcgcaacctt   6480

gaactcactc ttgttttaat agtgatcttg gtgacggagt gtcggtgagt gacaaccaac   6540

atcgtgcaag ggagattgat acggaattgt cgctcccatc atgatgttct tgccggcttt   6600

gttggcccta ttcgtgggat cgatgccctc ctgtgcagca gcaggtactg ctggatgagg   6660

agccatcggt ctctgcacgc aaacccaact tcctcttcat tctcacggat gatcaggatc   6720

tccggatgaa ttctccggcg tatatgccgt atacgcaggc gagaatcaag gaaaagggta   6780

ccgagttctt gaaccatttc gtcactaccg cgctttgctg tccgtcgcgc gtgagtcttt   6840

ggacgggaag acaggctcat aatactaatg tgacggatgt gaacccgcct tatggtatgg   6900

acactgcttc gatcggtctt gattcttcag cgtggttaca attgctaatg cggcataggc   6960

ggatacccca aattcgtcgc tcaaggcttc aacgaaaact tcctccccgt ttggctgcag   7020

tccgccggtt acaataccta ctacacgggg aagctgttca actcgcacag tgtcgctacc   7080

tataacgcgc cctttgtgaa cggtttcaat ggctccgact tcctcctcga cccccacaca   7140

tattcctact ggaatgcgac ataccagcga aaccatgagc ctccgcggag ttacgaggga   7200

caatatacta cggatgtgat gaaggagaag gcatcgggat tgttggcaga tgcgctggac   7260

agtgacgcgc cattcttcct gacggtcgcg ccgatcgcac cgcacacgaa catcgatgtg   7320

gaggggctga gcggtgcggg tggaccgaag atgacagagc cgctgcctgc accgagacat   7380

gcgcatttgt ttgctgatgc aaaggtgccg cggacgccta atttcaatcc ggacaaggtg   7440

tgtgatatcc tgacacagtg gtggggacgg gcactgacaa gagtaggatt ctggtgcggg   7500

gtggatccaa accatggaac tacagaacca gaccgtcatc gactacgaag accatcttta   7560

tcgccagcgt ctgcgcactt tgcaagccgt cgatgagatg gtggatgcgc tgatcacgca   7620

gctggaagaa agtgggcaga tcgacaatac ctacatcatt tacagtgctg ataacggcta   7680

ccacattggc catcaccgtc taccccccgg caagacaact ggctatgaag aggacattcg   7740

cgtaccattc tacattcgcg gacctggcat tcctgaggga aagagcgttg accgtgtaac   7800

cacgcacatt gacattgcac ctacactgtt cgagttggct ggggttccct tgcgagagga   7860

ctttgacggg actccgatgc ccgtgtcgac tagcaagaag acccagtcaa gcttgcatgc   7920

ctgcaggtcg actctagagg atctgccggt ctccctatag tgagtcgtat taatttcgat   7980

aagccaggtt aacctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   8040

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg   8100

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc   8160

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt   8220

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag   8280

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc   8340

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc   8400

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt   8460

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt   8520

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc   8580

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa   8640

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa   8700

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg   8760

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga   8820

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg   8880

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg   8940

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt   9000

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact   9060

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat   9120

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg   9180

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg   9240

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat   9300

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc   9360

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt   9420

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc   9480

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga   9540

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc   9600

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa   9660

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta   9720

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg   9780

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg   9840

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat   9900

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt   9960

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa  10020

aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct  10080

ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag  10140

acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc  10200

ggcatcagag cagattgtac tgagagtgca ccatatggac atattgtcgt tagaacgcgg  10260

ctacaattaa tacataacct tatgtatcat acacatacga tttaggtgac actatagaac  10320

tcgagcagct g                                                       10331


<210>  24
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Ser Asp Thr Ala Pro Ala Gly Phe Gln Leu Glu Lys Val Val Ile Leu 
1               5                   10                  15      


Ser Arg His Gly Val Arg Ala Pro Thr Lys Met Thr Gln Thr Met Arg 
            20                  25                  30          


Asp Val Thr Pro His Gln Trp Pro Glu Trp Pro Val Lys Leu Gly Tyr 
        35                  40                  45              


Ile Thr Pro Arg Gly Glu His Leu Ile Ser Leu Met Gly Gly Phe Tyr 
    50                  55                  60                  


Arg Glu Arg Phe Gln Gln Gln Gly Leu Leu Pro Lys Asp Asn Cys Pro 
65                  70                  75                  80  


Thr Pro Asp Ala Val Tyr Val Trp Thr Asp Val Asn Gln Arg Thr Arg 
                85                  90                  95      


Lys Thr Gly Glu Ala Phe Leu Ala Gly Leu Ala Pro Gln Cys Asp Leu 
            100                 105                 110         


Ala Ile His His Gln Gln Asn Ile Thr Gln Val Asp Pro Leu Phe His 
        115                 120                 125             


Pro Val Lys Ala Gly Ile Cys Ser Met Asn Lys Ser Gln Thr Tyr Glu 
    130                 135                 140                 


Ala Val Glu Lys Gln Ala Gly Gly Pro Ile Glu Thr Leu Asn Gln Arg 
145                 150                 155                 160 


Tyr Gln Ala Glu Leu Ala Leu Met Ser Ser Val Leu Asp Phe Pro Lys 
                165                 170                 175     


Ser Pro Tyr Cys Gln Gln His Asn Ile Gly Lys Leu Cys Asp Phe Ser 
            180                 185                 190         


Gln Ala Met Pro Ser Arg Leu Asn Ile Ser Asp Asp Gly Asn Glu Val 
        195                 200                 205             


Gln Leu Glu Gly Ala Val Gly Leu Gly Ser Thr Leu Ala Glu Ile Phe 
    210                 215                 220                 


Leu Leu Glu Tyr Ala Gln Gly Met Pro Val Val Ala Trp Gly Asn Ile 
225                 230                 235                 240 


His Asn Glu Ser Gln Trp Lys Ser Leu Leu Asn Leu His Asn Ala His 
                245                 250                 255     


Phe Asn Leu Met His Arg Thr Pro Tyr Ile Ala Lys His Gln Gly Thr 
            260                 265                 270         


Pro Leu Leu Gln Ala Ile Ser Asn Ala Leu Asn Pro Asn Ala Thr Glu 
        275                 280                 285             


Ser Lys Leu Pro Asp Ile Ser Pro Asp Asn Lys Ile Leu Phe Ile Ala 
    290                 295                 300                 


Gly His Asp Thr Asn Ile Ala Asn Ile Gly Gly Met Leu Gly Met Asn 
305                 310                 315                 320 


Trp Thr Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu 
                325                 330                 335     


Val Phe Glu Leu Trp Gln Asn Pro Asp Asn His Gln Gln Tyr Val Ala 
            340                 345                 350         


Val Lys Met Ile Tyr Gln Thr Met Asp Gln Leu Arg Asn Ser Glu Lys 
        355                 360                 365             


Leu Asp Leu Lys Ser Asn Pro Ala Gly Ile Val Pro Ile Glu Ile Glu 
    370                 375                 380                 


Gly Cys Glu Asn Ile Gly Thr Asp Lys Leu Cys Gln Leu Asp Thr Phe 
385                 390                 395                 400 


Gln Lys Arg Val Ala Gln Val Ile Glu Pro Ala Cys Gln Ile 
                405                 410                 


<210>  25
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic gene adapted to Aspergillus niger codon usage

<400>  25
agcgataccg cccccgcggg cttccagctg gagaaggtgg tcattctctc gcgtcacggt     60

gtccgagccc ccaccaagat gacacagacg atgcgcgatg tcactccaca tcagtggcct    120

gagtggcccg tgaagctcgg ctacatcact cctcgtggag aacacctcat cagcctgatg    180

ggcggtttct atagggaacg gttccagcag cagggattgc ttcccaagga caactgtccg    240

acccccgacg ccgtctacgt gtggaccgac gttaaccagc gtacccgcaa gactggagag    300

gctttcctcg ccggtcttgc gcctcagtgt gatctggcca tccaccacca gcagaacatc    360

acgcaggtcg acccgctgtt tcacccggtc aaggccggta tctgttcgat gaacaagtct    420

cagacctatg aggctgtcga gaagcaggct ggcggcccta ttgagacgct aaaccagcgc    480

taccaggccg aactggcatt gatgtcctct gtgttggatt tccccaagtc cccatattgc    540

cagcagcata acatcggcaa actgtgcgac ttttcacagg ctatgcctag ccgcctcaac    600

atctccgatg acgggaatga ggtgcaactc gaaggcgccg tcggtcttgg ttccacgctc    660

gccgagatct tcctactgga atacgctcag ggtatgcctg tggtcgcctg gggcaacatt    720

cacaacgaga gccagtggaa gagcctcctt aacttgcaca acgcccattt caacctgatg    780

cacagaacgc cctacattgc caagcaccag ggaacccctt tacttcaggc tatcagcaac    840

gctctcaacc caaatgcaac tgagtcgaag ctccccgata tctctcccga caacaagatc    900

cttttcattg ccggccacga caccaacatc gcaaacatcg gaggcatgtt gggtatgaac    960

tggactctcc cgggccagcc agacaatact ccgcccggcg gtggactggt tttcgaactc   1020

tggcagaacc cggataacca tcagcagtac gttgcggtga agatgatcta ccagaccatg   1080

gaccagctgc gcaattccga gaagctggac ttgaagagca accctgctgg gatcgtcccc   1140

attgagatcg aaggttgcga gaacatcggt accgacaagc tgtgccagct ggatactttt   1200

cagaagcgtg ttgcccaggt cattgagccc gcgtgccaaa tctaa                   1245


<210>  26
<211>  10331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26
aagcttgcat gagcatgtca cagtcgaatt ctggggtcac gcggtgcttg agggcgaata     60

cggctccatc ggtgagtaac ctctctctta ctaccacgga aacatcactg acgtaaccag    120

gacccggcgg cttatccatc atgggaaaca acacctacaa atccgccaga attctctcgg    180

aagaatataa cctctactac tccgtctggt gcgacggtga ccacgagctg tacgatctct    240

cagtaagtgc caaccggttc ccgccactat cgtaaaaaca aaaaatctaa caacaccaga    300

cggaccccta ccaaatgaac aacatctaca cccaacaaga caacatccac ctcctaagca    360

gacctctatc cagcgtgatt gatcgtatcg acgctctcct tctggttctg aaatcctgca    420

agggtaacac atgcatccag ccgtggcggg tcctccaccc cgacgggtcc gtagagagcc    480

tcaaagatgc actgcaggtg aaatacgatt ccttttacac caaccagccc aaggtgtcgt    540

attcagtatg tgaacccggg tacatcattg aggctgaggg gccccaggtc ggattgcagt    600

atagagatgg gctgagttgg gaggcgtgga cttgacgatt ccgtcaagta tgagtatggg    660

tacgaataat gagcgttatt gctatgtatt tttatagata gtttatttat atatcatgac    720

taaacttgag agccatggaa tcaatgaaat gacatggcga gtgtagatca cgatagtcat    780

agtagccgaa gtgggcggat agccaagaat aacaccagaa tcagataaca ggaacatcac    840

aaccgatcac accatagata atatccaaag aagtttaaat agccgagaca aagagaatag    900

agacaagata catggaacaa gaaaggtaca cccggtagat aaaccctggg acgggcccga    960

gtccttaccc atagatcaat cccacgggaa caaaaccaaa gtcaacaacc accaccacca   1020

ttaccacaac cgcatcaata gaaccggtga aaaatgacac catcgaatcc ttcaccctaa   1080

gtaaagccct gtacgttgca tatcgcttaa gcacaaaagt agtagaatag atatgagccc   1140

gcacgcgcgg ccaacgatcc aaactagccc tgacatcaaa gccagcggcg attgcgccat   1200

caagcccccg tctcacttca tagtggaatt gcgggtcacc tcactgattg actgtctgtc   1260

tagacacact cacccacgca tgctgtctgt gcccagaacg tggactttgg ctctgccgag   1320

ctagaggatc aaatataagt agattggatg taggcccgta ttttttttat ttcgtgtgac   1380

tcggagattt tatgcgttgt gttgttgggc ggaaaaagaa atatactttc tttttgttct   1440

tttctttttc tctctattgc ttgccttgga tatcccttgc atacggtcgg ttgctgattg   1500

actaagggtg ctgtcttgtg tcactgaact gctgctcaac ctctgtctgg tattcctgtt   1560

gtcgtgatgg tggggaaaca gttcgagttc gaggaccaga gggatggcat cgtgcctccc   1620

ttggaggaaa agaaggtcgt cgatgaggtc tataccgata atgatgttgc gtcggaggag   1680

attgtcaagg actgggatga taaggaggag ggcaagctgc ggaggaagtg agtcgtcact   1740

gttttcattc actgccatat aggttcaagc atatactgac tggtatatag gatcgatatc   1800

atcctcatcc ccattctcgc tctcgctttc ttcggcctcc agattgatcg cggcaatatc   1860

agcgcagctc ttacctccac tatcaccgaa gacctaggtg tcaccacgaa ccaaatcaat   1920

attggaaccc agttgctttc ggctggtatt gtcatcaccg agatcccgtc aaatattata   1980

cttcagcgca tcggtcccca ggtctggttg tcggcacagc tgatcgcttg gggtctggtt   2040

ggcacattcc aggcttttgt acagtcgtac ccggcgtatc tggccacgag gttgttgctg   2100

gggctgttgg agggagggtt tattcctggt ttgtctggtc gtgcgccttg gtctatggtg   2160

gtagcgctaa caatgggttt ggtacaggtg ccctgtacta tctctcgaca tggtataaac   2220

gtcctgagac gagtttccgg accactctgt tcttctatgg gcagatgttt gccggtgcga   2280

cctcgagcgg ccgcttcgag gattgcctga acattgacat tcggcgtccg gccgggacca   2340

ccgcggactc gaagctgcct gtgctggtct ggatctttgg cggaggcttt gaacttggtt   2400

caaaggcgat gtatgatggt acaacgatgg tatcatcgtc gatagacaag aacatgccta   2460

tcgtgtttgt agcaatgaat tatcgcgtgg gaggtttcgg gttcttgccc ggaaaggaga   2520

tcctggagga cgggtccgcg aacctagggc tcctggacca acgccttgcc ctgcagtggg   2580

ttgccgacaa catcgaggcc tttggtggag acccggacaa ggtgacgatt tggggagaat   2640

cagcaggagc catttccgtt tttgatcaga tgatcttgta cgacggaaac atcacttaca   2700

aggataagcc cttgttccgg ggggccatca tggactccgg tagtgttgtt cccgcagacc   2760

ccgtcgatgg ggtcaaggga cagcaagtat atgatgcggt agtggaatct gcaggctgtt   2820

cctcttctaa cgacacccta gcttgtctgc gtgaactaga ctacaccgac ttcctcaatg   2880

cggcaaactc cgtgccaggc attttaagct accattctgt ggcgttatca tatgtgcctc   2940

gaccggacgg gacggcgttg tcggcatcac cggacgtttt gggcaaagca gggaaatatg   3000

ctcgggtccc gttcatcgtg ggcgaccaag aggatgaggg gaccttattc gccttgtttc   3060

agtccaacat tacgacgatc gacgaggtgg tcgactacct ggcctcatac ttcttctatg   3120

acgctagccg agagcagctt gaagaactag tggccctgta cccagacacc accacgtacg   3180

ggtctccgtt caggacaggc gcggccaaca actggtatcc gcaatttaag cgattggccg   3240

ccattctcgg cgacttggtc ttcaccatta cccggcgggc attcctctcg tatgcagagg   3300

aaatctcccc tgatcttccg aactggtcgt acctggcgac ctatgactat ggcaccccag   3360

ttctggggac cttccacgga agtgacctgc tgcaggtgtt ctatgggatc aagccaaact   3420

atgcagctag ttctagccac acgtactatc tgagctttgt gtatacgctg gatccgaact   3480

ccaaccgggg ggagtacatt gagtggccgc agtggaagga atcgcggcag ttgatgaatt   3540

tcggagcgaa cgacgccagt ctccttacgg atgatttccg caacgggaca tatgagttca   3600

tcctgcagaa taccgcggcg ttccacatct gatgccattg gcggaggggt ccggacggtc   3660

aggaacttag ccttatgaga tgaatgatgg acgtgtctgg cctcggaaaa ggatatatgg   3720

ggatcatgat agtactagcc atattaatga agggcatata ccacgcgttg gacctgcgtt   3780

atagcttccc gttagttata gtaccatcgt tataccagcc aatcaagtca ccacgcacga   3840

ccggggacgg cgaatccccg ggaattgaaa gaaattgcat cccaggccag tgaggccagc   3900

gattggccac ctctccaagg cacagggcca ttctgcagcg ctggtggatt catcgcaatt   3960

tcccccggcc cggcccgaca ccgctatagg ctggttctcc cacaccatcg gagattcgtc   4020

gcctaatgtc tcgtccgttc acaagctgaa gagcttgaag tggcgagatg tctctgcagg   4080

aattcaagct agatgctaag cgatattgca tggcaatatg tgttgatgca tgtgcttctt   4140

ccttcagctt cccctcgtgc agatgaggtt tggctataaa ttgaagtggt tggtcggggt   4200

tccgtgaggg gctgaagtgc ttcctccctt ttagacgcaa ctgagagcct gagcttcatc   4260

cccagcatca ttacacctca gcaatgggcg tctctgctgt tctacttcct ttgtatctcc   4320

tgtctgggta tgctaagcac cacaatcaaa gtctaataag gaccctccct tccgagggcc   4380

cctgaagctc ggactgtgtg ggactactga tcgctgacta tctgtgcaga gtcacctccg   4440

gactggcagt ccccagcgat accgcccccg cgggcttcca gctggagaag gtggtcattc   4500

tctcgcgtca cggtgtccga gcccccacca agatgacaca gacgatgcgc gatgtcactc   4560

cacatcagtg gcctgagtgg cccgtgaagc tcggctacat cactcctcgt ggagaacacc   4620

tcatcagcct gatgggcggt ttctataggg aacggttcca gcagcaggga ttgcttccca   4680

aggacaactg tccgaccccc gacgccgtct acgtgtggac cgacgttaac cagcgtaccc   4740

gcaagactgg agaggctttc ctcgccggtc ttgcgcctca gtgtgatctg gccatccacc   4800

accagcagaa catcacgcag gtcgacccgc tgtttcaccc ggtcaaggcc ggtatctgtt   4860

cgatgaacaa gtctcagacc tatgaggctg tcgagaagca ggctggcggc cctattgaga   4920

cgctaaacca gcgctaccag gccgaactgg cattgatgtc ctctgtgttg gatttcccca   4980

agtccccata ttgccagcag cataacatcg gcaaactgtg cgacttttca caggctatgc   5040

ctagccgcct caacatctcc gatgacggga atgaggtgca actcgaaggc gccgtcggtc   5100

ttggttccac gctcgccgag atcttcctac tggaatacgc tcagggtatg cctgtggtcg   5160

cctggggcaa cattcacaac gagagccagt ggaagagcct ccttaacttg cacaacgccc   5220

atttcaacct gatgcacaga acgccctaca ttgccaagca ccagggaacc cctttacttc   5280

aggctatcag caacgctctc aacccaaatg caactgagtc gaagctcccc gatatctctc   5340

ccgacaacaa gatccttttc attgccggcc acgacaccaa catcgcaaac atcggaggca   5400

tgttgggtat gaactggact ctcccgggcc agccagacaa tactccgccc ggcggtggac   5460

tggttttcga actctggcag aacccggata accatcagca gtacgttgcg gtgaagatga   5520

tctaccagac catggaccag ctgcgcaatt ccgagaagct ggacttgaag agcaaccctg   5580

ctgggatcgt ccccattgag atcgaaggtt gcgagaacat cggtaccgac aagctgtgcc   5640

agctggatac ttttcagaag cgtgttgccc aggtcattga gcccgcgtgc caaatctaaa   5700

caatcaatcc atttcgctat agttaaagga tggggatgag ggcaattggt tatatgatca   5760

tgtatgtagt gggtgtgcat aatagtagtg aaatggaagc caagtcatgt gattgtaatc   5820

gaccgacgga attgaggata tccggaaata cagacaccgt gaaagccatg gtctttcctt   5880

cgtgtagaag accagacaga cagtccctga tttaccctgc acaaagcact agaaaattag   5940

cattccatcc ttctctgctt gctctgctga tatcactgtc attcaatgca tagccatgag   6000

ctcatcttag atccaagcac gtaattccat agccgaggtc cacagtggag cagcaacatt   6060

ccccatcatt gctttcccca ggggcctccc aacgactaaa tcaagagtat atctctaccg   6120

tccaatagat cgtcttcgct tcaaaatctt tgacaattcc aagagggtcc ccatccatca   6180

aacccagttc aataatagcc gagatgcatg gtggagtcaa ttaggcagta ttgctggaat   6240

gtcggggcca gttccgggtg gtcattggcc gcctgtgatg ccatctgcca ctaaatccga   6300

tcattgatcc accgcccacg agggcgtctt tgctttttgc gcggcgtcca ggttcaactc   6360

tctctgcagc tccagtccaa cgctgactga ctagtttacc tactggtctg atcggctcca   6420

tcagagctat ggcgttatcc cgtgccgttg ctgcgcaatc gctatcttga tcgcaacctt   6480

gaactcactc ttgttttaat agtgatcttg gtgacggagt gtcggtgagt gacaaccaac   6540

atcgtgcaag ggagattgat acggaattgt cgctcccatc atgatgttct tgccggcttt   6600

gttggcccta ttcgtgggat cgatgccctc ctgtgcagca gcaggtactg ctggatgagg   6660

agccatcggt ctctgcacgc aaacccaact tcctcttcat tctcacggat gatcaggatc   6720

tccggatgaa ttctccggcg tatatgccgt atacgcaggc gagaatcaag gaaaagggta   6780

ccgagttctt gaaccatttc gtcactaccg cgctttgctg tccgtcgcgc gtgagtcttt   6840

ggacgggaag acaggctcat aatactaatg tgacggatgt gaacccgcct tatggtatgg   6900

acactgcttc gatcggtctt gattcttcag cgtggttaca attgctaatg cggcataggc   6960

ggatacccca aattcgtcgc tcaaggcttc aacgaaaact tcctccccgt ttggctgcag   7020

tccgccggtt acaataccta ctacacgggg aagctgttca actcgcacag tgtcgctacc   7080

tataacgcgc cctttgtgaa cggtttcaat ggctccgact tcctcctcga cccccacaca   7140

tattcctact ggaatgcgac ataccagcga aaccatgagc ctccgcggag ttacgaggga   7200

caatatacta cggatgtgat gaaggagaag gcatcgggat tgttggcaga tgcgctggac   7260

agtgacgcgc cattcttcct gacggtcgcg ccgatcgcac cgcacacgaa catcgatgtg   7320

gaggggctga gcggtgcggg tggaccgaag atgacagagc cgctgcctgc accgagacat   7380

gcgcatttgt ttgctgatgc aaaggtgccg cggacgccta atttcaatcc ggacaaggtg   7440

tgtgatatcc tgacacagtg gtggggacgg gcactgacaa gagtaggatt ctggtgcggg   7500

gtggatccaa accatggaac tacagaacca gaccgtcatc gactacgaag accatcttta   7560

tcgccagcgt ctgcgcactt tgcaagccgt cgatgagatg gtggatgcgc tgatcacgca   7620

gctggaagaa agtgggcaga tcgacaatac ctacatcatt tacagtgctg ataacggcta   7680

ccacattggc catcaccgtc taccccccgg caagacaact ggctatgaag aggacattcg   7740

cgtaccattc tacattcgcg gacctggcat tcctgaggga aagagcgttg accgtgtaac   7800

cacgcacatt gacattgcac ctacactgtt cgagttggct ggggttccct tgcgagagga   7860

ctttgacggg actccgatgc ccgtgtcgac tagcaagaag acccagtcaa gcttgcatgc   7920

ctgcaggtcg actctagagg atctgccggt ctccctatag tgagtcgtat taatttcgat   7980

aagccaggtt aacctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   8040

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg   8100

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc   8160

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt   8220

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag   8280

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc   8340

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc   8400

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt   8460

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt   8520

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc   8580

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa   8640

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa   8700

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg   8760

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga   8820

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg   8880

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg   8940

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt   9000

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact   9060

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat   9120

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg   9180

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg   9240

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat   9300

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc   9360

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt   9420

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc   9480

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga   9540

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc   9600

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa   9660

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta   9720

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg   9780

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg   9840

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat   9900

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt   9960

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa  10020

aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct  10080

ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag  10140

acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc  10200

ggcatcagag cagattgtac tgagagtgca ccatatggac atattgtcgt tagaacgcgg  10260

ctacaattaa tacataacct tatgtatcat acacatacga tttaggtgac actatagaac  10320

tcgagcagct g                                                       10331


