                         SEQUENCE LISTING

<110>  Bayer Pharma AG
       Bayer Intellectual Property GmbH
 
<120>  Neue Binder-Wirkstoff-Konjugate (ADCs) und ihre Verwendung

<130>  BHC 11 1 011

<160>  411   

<170>  PatentIn version 3.5

<210>  1
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  1

Leu Glu Cys Tyr Ser Cys Val Gln Lys Ala Asp Asp Gly Cys Ser Pro 
1               5                   10                  15      


Asn Lys Met Lys Thr Val Lys Cys Ala Pro Gly Val Asp Val Cys Thr 
            20                  25                  30          


Glu Ala Val Gly Ala Val Glu Thr Ile His Gly Gln Phe Ser Leu Ala 
        35                  40                  45              


Val Arg Gly Cys Gly Ser Gly Leu Pro Gly Lys Asn Asp Arg Gly Leu 
    50                  55                  60                  


Asp Leu His Gly Leu Leu Ala Phe Ile Gln Leu Gln Gln Cys Ala Gln 
65                  70                  75                  80  


Asp Arg Cys Asn Ala Lys Leu Asn Leu Thr Ser Arg Ala Leu Asp Pro 
                85                  90                  95      


Ala Gly Asn Glu Ser Ala Tyr Pro Pro Asn Gly Val Glu Cys Tyr Ser 
            100                 105                 110         


Cys Val Gly Leu Ser Arg Glu Ala Cys Gln Gly Thr Ser Pro Pro Val 
        115                 120                 125             


Val Ser Cys Tyr Asn Ala Ser Asp His Val Tyr Lys Gly Cys Phe Asp 
    130                 135                 140                 


Gly Asn Val Thr Leu Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val 
145                 150                 155                 160 


Arg Gly Cys Val Gln Asp Glu Phe Cys Thr Arg Asp Gly Val Thr Gly 
                165                 170                 175     


Pro Gly Phe Thr Leu Ser Gly Ser Cys Cys Gln Gly Ser Arg Cys Asn 
            180                 185                 190         


Ser Asp Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile Pro Pro Leu 
        195                 200                 205             


Val Arg Leu Pro Pro Pro Glu Pro Thr Thr Val Ala Ser Thr Thr Ser 
    210                 215                 220                 


Val Thr Thr Ser Thr Ser Ala Pro Val Arg Pro Thr Ser Thr Thr Lys 
225                 230                 235                 240 


Pro Met Pro Ala Pro Thr Ser Gln Thr Pro Arg Gln Gly Val Glu His 
                245                 250                 255     


Glu Ala Ser Arg Asp Glu Glu Pro Arg Leu Thr Gly Gly Ala Ala Gly 
            260                 265                 270         


His Gln Asp Arg Ser Asn 
        275             


<210>  2
<211>  293
<212>  PRT
<213>  Mus musculus

<400>  2

Leu Glu Cys Tyr Ser Cys Val Gln Lys Ala Asp Asp Gly Cys Ser Pro 
1               5                   10                  15      


His Arg Met Lys Thr Val Lys Cys Gly Pro Gly Val Asp Val Cys Thr 
            20                  25                  30          


Glu Ala Val Gly Ala Val Glu Thr Ile His Gly Gln Phe Ser Val Ala 
        35                  40                  45              


Val Arg Gly Cys Gly Ser Gly Ile Pro Gly Lys Asn Asp Arg Gly Leu 
    50                  55                  60                  


Asp Leu His Gly Leu Leu Ala Phe Phe Gln Leu Gln Gln Cys Ser Glu 
65                  70                  75                  80  


Asp Arg Cys Asn Ala Lys Leu Asn Leu Thr Leu Arg Gly Leu Asn Pro 
                85                  90                  95      


Ala Gly Asn Glu Ser Ala Tyr Glu Pro Asn Gly Ala Glu Cys Tyr Ser 
            100                 105                 110         


Cys Val Gly Leu Ser Arg Glu Lys Cys Gln Gly Ser Met Pro Pro Val 
        115                 120                 125             


Val Asn Cys Tyr Asn Ala Ser Gly Arg Val Tyr Lys Gly Cys Phe Asp 
    130                 135                 140                 


Gly Asn Val Thr Leu Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val 
145                 150                 155                 160 


Arg Gly Cys Val Gln Asp Glu Thr Cys Thr Arg Asp Gly Val Thr Gly 
                165                 170                 175     


Pro Gly Phe Thr Leu Ser Gly Ser Cys Cys Gln Gly Pro Arg Cys Asn 
            180                 185                 190         


Ala Asp Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile Pro Pro Leu 
        195                 200                 205             


Val Leu Leu Pro Pro Pro Thr Thr Ala Ala Pro Ser Thr Arg Ala Gln 
    210                 215                 220                 


Asn Ser Ser Ser Thr Thr Ser Thr Ala Ala Pro Thr Thr Thr Thr Ser 
225                 230                 235                 240 


Ile Ile Lys Pro Thr Thr Ala Gln Ala Ser His Thr Ser Pro His Glu 
                245                 250                 255     


Met Asp Leu Glu Val Ile Gln Glu Glu Gly Ala Ser Leu Ser Gly Gly 
            260                 265                 270         


Ala Ala Gly His Gly Gly Thr Ala Gly His Gly Gly Ala Ala Gly His 
        275                 280                 285             


Gln Asp Arg Ser Asn 
    290             


<210>  3
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Asp Pro Ala Arg Lys Ala Gly Ala Gln Ala Met Ile Trp Thr Ala 
1               5                   10                  15      


Gly Trp Leu Leu Leu Leu Leu Leu Arg Gly Gly Ala Gln Ala Leu Glu 
            20                  25                  30          


Cys Tyr Ser Cys Val Gln Lys Ala Asp Asp Gly Cys Ser Pro Asn Lys 
        35                  40                  45              


Met Lys Thr Val Lys Cys Ala Pro Gly Val Asp Val Cys Thr Glu Ala 
    50                  55                  60                  


Val Gly Ala Val Glu Thr Ile His Gly Gln Phe Ser Leu Ala Val Arg 
65                  70                  75                  80  


Gly Cys Gly Ser Gly Leu Pro Gly Lys Asn Asp Arg Gly Leu Asp Leu 
                85                  90                  95      


His Gly Leu Leu Ala Phe Ile Gln Leu Gln Gln Cys Ala Gln Asp Arg 
            100                 105                 110         


Cys Asn Ala Lys Leu Asn Leu Thr Ser Arg Ala Leu Asp Pro Ala Gly 
        115                 120                 125             


Asn Glu Ser Ala Tyr Pro Pro Asn Gly Val Glu Cys Tyr Ser Cys Val 
    130                 135                 140                 


Gly Leu Ser Arg Glu Ala Cys Gln Gly Thr Ser Pro Pro Val Val Ser 
145                 150                 155                 160 


Cys Tyr Asn Ala Ser Asp His Val Tyr Lys Gly Cys Phe Asp Gly Asn 
                165                 170                 175     


Val Thr Leu Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val Arg Gly 
            180                 185                 190         


Cys Val Gln Asp Glu Phe Cys Thr Arg Asp Gly Val Thr Gly Pro Gly 
        195                 200                 205             


Phe Thr Leu Ser Gly Ser Cys Cys Gln Gly Ser Arg Cys Asn Ser Asp 
    210                 215                 220                 


Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile Pro Pro Leu Val Arg 
225                 230                 235                 240 


Leu Pro Pro Pro Glu Pro Thr Thr Val Ala Ser Thr Thr Ser Val Thr 
                245                 250                 255     


Thr Ser Thr Ser Ala Pro Val Arg Pro Thr Ser Thr Thr Lys Pro Met 
            260                 265                 270         


Pro Ala Pro Thr Ser Gln Thr Pro Arg Gln Gly Val Glu His Glu Ala 
        275                 280                 285             


Ser Arg Asp Glu Glu Pro Arg Leu Thr Gly Gly Ala Ala Gly His Gln 
    290                 295                 300                 


Asp Arg Ser Asn Ser Gly Gln Tyr Pro Ala Lys Gly Gly Pro Gln Gln 
305                 310                 315                 320 


Pro His Asn Lys Gly Cys Val Ala Pro Thr Ala Gly Leu Ala Ala Leu 
                325                 330                 335     


Leu Leu Ala Val Ala Ala Gly Val Leu Leu 
            340                 345     


<210>  4
<211>  363
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asp Ala Ala Arg Arg Gly Asp Thr Gln Pro Val Met Trp Thr Thr 
1               5                   10                  15      


Gly Trp Leu Leu Leu Leu Pro Leu Leu Leu Cys Glu Gly Ala Gln Ala 
            20                  25                  30          


Leu Glu Cys Tyr Ser Cys Val Gln Lys Ala Asp Asp Gly Cys Ser Pro 
        35                  40                  45              


His Arg Met Lys Thr Val Lys Cys Gly Pro Gly Val Asp Val Cys Thr 
    50                  55                  60                  


Glu Ala Val Gly Ala Val Glu Thr Ile His Gly Gln Phe Ser Val Ala 
65                  70                  75                  80  


Val Arg Gly Cys Gly Ser Gly Ile Pro Gly Lys Asn Asp Arg Gly Leu 
                85                  90                  95      


Asp Leu His Gly Leu Leu Ala Phe Phe Gln Leu Gln Gln Cys Ser Glu 
            100                 105                 110         


Asp Arg Cys Asn Ala Lys Leu Asn Leu Thr Leu Arg Gly Leu Asn Pro 
        115                 120                 125             


Ala Gly Asn Glu Ser Ala Tyr Glu Pro Asn Gly Ala Glu Cys Tyr Ser 
    130                 135                 140                 


Cys Val Gly Leu Ser Arg Glu Lys Cys Gln Gly Ser Met Pro Pro Val 
145                 150                 155                 160 


Val Asn Cys Tyr Asn Ala Ser Gly Arg Val Tyr Lys Gly Cys Phe Asp 
                165                 170                 175     


Gly Asn Val Thr Leu Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val 
            180                 185                 190         


Arg Gly Cys Val Gln Asp Glu Thr Cys Thr Arg Asp Gly Val Thr Gly 
        195                 200                 205             


Pro Gly Phe Thr Leu Ser Gly Ser Cys Cys Gln Gly Pro Arg Cys Asn 
    210                 215                 220                 


Ala Asp Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile Pro Pro Leu 
225                 230                 235                 240 


Val Leu Leu Pro Pro Pro Thr Thr Ala Ala Pro Ser Thr Arg Ala Gln 
                245                 250                 255     


Asn Ser Ser Ser Thr Thr Ser Thr Ala Ala Pro Thr Thr Thr Thr Ser 
            260                 265                 270         


Ile Ile Lys Pro Thr Thr Ala Gln Ala Ser His Thr Ser Pro His Glu 
        275                 280                 285             


Met Asp Leu Glu Val Ile Gln Glu Glu Gly Ala Ser Leu Ser Gly Gly 
    290                 295                 300                 


Ala Ala Gly His Gly Gly Thr Ala Gly His Gly Gly Ala Ala Gly His 
305                 310                 315                 320 


Gln Asp Arg Ser Asn Met Glu Lys Tyr Pro Gly Lys Gly Gly Ala Gln 
                325                 330                 335     


Ile Pro Ala Lys Gly Gly Ser Gly Thr Leu Gly Ser Trp Leu Ser Ala 
            340                 345                 350         


Val Leu Leu Thr Val Val Ala Gly Ala Met Leu 
        355                 360             


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  5

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  6

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  7

Phe Gly His Tyr Tyr Met Phe Trp Ile 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  8

Phe Ser Ser Asn Tyr Met Ser Trp 
1               5               


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  9

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  10

Val Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  11

Val Ser Ala Ile Ser Gly Ser Gly Tyr Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  12

Val Ser Ala Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  13

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  14

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser 
1               5                   10                  15  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  15

Ala Arg Leu Pro Tyr Gly Ser Gln Ser Gly Val Asp Tyr 
1               5                   10              


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  16

Ala Arg Glu Ser Gly Gly Ser Gly Pro Asn Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  17

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  18

Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  19

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  20

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  21

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  22

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  23

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  24

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  25

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Pro Val 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  26

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Trp Val 
1               5                   10          


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  27

Cys Gln Ser Tyr Asp Ser Ser His Val Leu 
1               5                   10  


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  28

Cys Gln Ser Tyr Asp Arg Ser Leu Arg Gly Trp Val 
1               5                   10          


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  29

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  30

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  31

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  32

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  33
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Thr Ser 
        115                 120         


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Tyr Met Phe Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Tyr Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Tyr Gly Ser Gln Ser Gly Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Thr Ser 
        115                 120 


<210>  36
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Gly Ser Gly Pro Asn Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Thr Ser 
        115                 120                 


<210>  37
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  37
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ctgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacattggg gcgggttatg ttgtacattg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatgacaata ataagcgacc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagcatggg atgacaggct gaatggtccg      300

gtgttcggcg gaggaaccaa gttaaccgtc ctaggtcag                             339


<210>  38
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  38
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacgtcggg agtaatcctg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acaggctgaa tggttgggtg      300

ttcggcggag gaaccaagct gacggtccta ggtcag                                336


<210>  39
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  39
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacattggg gcgggttatg ttgtacattg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatagtaata atcagcggcc ctcaggagtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgc cagtcctatg acagcagcca tgttttattc      300

ggcggaggaa ccaagctgac ggtcctaggt cag                                   333


<210>  40
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  40
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacattggg gcgggttatg ttgtacattg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatagtaata atcagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgc cagtcctatg acagaagcct gcgtggttgg      300

gtgttcggcg gaggaaccaa gctgacggtc ctaggtcag                             339


<210>  41
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  41
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagaaggg      300

ttatgggcct ttgactactg gggccagggt accctggtca ccgtgactag t               351


<210>  42
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  42
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactatcaga tgacctggat ccgccagact      120

ccagggaagg ggctggagtg ggtatcgggt gttagttgga atggcgctag gacgcactat      180

gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctacaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gaagggcgac      300

tacctggttt actccgcata ctactttgac tcctggggcc agggtaccct ggtcaccgtg      360

actagt                                                                 366


<210>  43
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  43
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcggt cactactata tgttctggat ccgtcaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggttatag cacacactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagactgcca      300

tatggttcgc agagtggcgt tgactactgg ggccagggta ccctggtcac cgtgactagt      360


<210>  44
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  44
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtagta gtggtagtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagaatct      300

ggtgggagcg gaccgaacta ctactacggt atggacgtct ggggccaagg taccctggtc      360

accgtgacta gt                                                          372


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  45

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  46

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  47

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  48

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  49

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  50

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Pro Val 
1               5                   10          


<210>  51
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  52
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  52

Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  53
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  53
gaggtgcagc tgctggaaag cggcggagga ctggtgcagc ctggaggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc aacgcctgga tgagctgggt ccgacaggct      120

cctggcaagg gcctggaatg ggtgtcctac atcagcagca gcggcagcac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagagaaggc      300

ctgtgggcct tcgactactg gggccagggc accctggtca ccgtgtctag c               351


<210>  54
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  54
gagagcgtgc tgacccagcc tcctagcgtg tccggcgctc ctggccagag agtgaccatc       60

agctgcaccg gcagcagcag caacatcgga gccggctacg tggtgcactg gtatcagcag      120

ctgcccggca ccgcccccaa gctgctgatc tacgacaaca acaagcggcc tagcggcgtg      180

cccgacagat tcagcggcag caagagcggc accagcgcca gcctggccat cagcggcctg      240

agaagcgagg acgaggccga ctactactgc gccgcctggg acgacagact gaacggccct      300

gtgttcggcg gaggcaccaa gctgaccgtg ctgggacag                             339


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  55

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  56

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  57

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  58

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  59

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  60

Cys Ala Ala Tyr Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10          


<210>  61
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  62

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  63
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  63
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg ccagcggctt taccttctcc aacgcctgga tgtcctgggt ccgacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atctcctcct ccggctccac catctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc ccgagagggc      300

ctgtgggcct tcgattattg gggccagggc accctggtca ccgtcagctc a               351


<210>  64
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  64
cagtccgtgc tgacccagcc cccttctgtg tctggcgccc ctggccagag agtgaccatc       60

tcttgcaccg gctcctccag caacatcggc gctggctacg tggtgcactg gtatcagcag      120

ctgcccggca ccgcccccaa gctgctgatc tacgacaaca acaagcggcc ctccggcgtg      180

cccgacagat tctccggctc caagtccggc acctccgcct ccctggccat ctccggcctg      240

agatctgagg acgaggccga ctactactgc gccgcctacg acgactccct gtccggccct      300

gtgttcggcg gaggcacaaa gttaaccgtg ctgggccag                             339


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  65

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  66
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  66

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  67

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  68

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  69

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  70

Cys Ala Ala Phe Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  72
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  72

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  73
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  73
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt taccttctcc aacgcctgga tgtcctgggt ccgacaggct      120

cctggcaagg gcctggaatg ggtgtcctac atctcctcct ccggctccac catctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc ccgagagggc      300

ctgtgggcct tcgataagtg gggccagggc accctggtca ccgtcagctc a               351


<210>  74
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  74
cagtccgtgc tgacccagcc tccttccgcc tctggcaccc ctggccagag agtgaccatc       60

tcctgcaccg gctcctccag caacatcggc gctggctacg tggtgcactg gtatcagcag      120

ctgcccggca ccgcccccaa gctgctgatc tacgacaaca acaagcggcc ctccggcgtg      180

cccgacagat tctccggctc caagtccggc acctccgcct ccctggccat ctccggcctg      240

agatctgagg acgaggccga ctactactgc gccgccttcg acgaccggct gaacggccct      300

gtgttcggcg gaggcacaaa gttaaccgtg ctgggccag                             339


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  75

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  76

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  77

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  78

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  79

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  80

Cys Ala Ala Tyr Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10          


<210>  81
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  82
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  82

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  83
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  83
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg ccagcggctt taccttctcc agcgcctgga tgtcctgggt ccgacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atctcctcct ccggctccac catctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc ccgagagggc      300

ctgtgggcct tcgattattg gggccagggc accctggtca ccgtcagctc a               351


<210>  84
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  84
cagtccgtgc tgacccagcc cccttctgtg tctggcgccc ctggccagag agtgaccatc       60

tcttgcaccg gctcctccag caacatcggc gctggctacg tggtgcactg gtatcagcag      120

ctgcccggca ccgcccccaa gctgctgatc tacgacaaca acaagcggcc ctccggcgtg      180

cccgacagat tctccggctc caagtccggc acctccgcct ccctggccat ctccggcctg      240

agatctgagg acgaggccga ctactactgc gccgcctacg acgactccct gtccggccct      300

gtgttcggcg gaggcacaaa gttaaccgtg ctgggccag                             339


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  85

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  86

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  87

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  88

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  89

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  90

Cys Ala Ala Phe Asp Asp Arg Leu Ser Gly Pro Val 
1               5                   10          


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  92
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Arg 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  93
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  93
gaggtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agcgcctgga tgagctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtgtcctac atcagcagca gcggcagcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagagaaggc      300

ctgtgggcct tcgataagtg gggccagggc accctggtca ccgtcagctc a               351


<210>  94
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  94
cagagcgtgc tgacccagcc tcctagcgcc tctggcaccc ctggccagag agtgaccatc       60

agctgcagcg gcagcagcag caacatcgga gccggctacg tggtgcactg gtatcagcag      120

ctgcccggca ccgcccccaa gctgctgatc tacgacaaca accagcggcc cagcggcgtg      180

cccgacagat tttccggcag caagagcggc accagcgcca gcctggccat cagcggcctg      240

agaagcgagg acgaggccga ctactactgc gccgccttcg acgacagact gagcggccct      300

gtgttcggcg gaggcacaaa gttaaccgtg ctgggccag                             339


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  95

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  96

Val Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  97

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser 
1               5                   10                  15  


<210>  98
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  98

Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  99

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  100

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Trp Val 
1               5                   10          


<210>  101
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  101

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  102
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  102

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  103
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  103
gaggtgcagc tgctggaaag cggcggagga ctggtgcagc ctggaggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc gactaccaga tgacctggat ccgacagacc      120

cctggcaagg gcctggaatg ggtgtccggc atcagctgga acggaggcag cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggcgac      300

tacctggtgt acagcgccta ctacttcgac agctggggcc agggcaccct ggtcaccgtg      360

tctagc                                                                 366


<210>  104
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  104
gagagcgtgc tgacccagcc tcctagcgcc tctggcaccc ctggccagag agtgaccatc       60

agctgctctg gcagcagcag caacatcgga agcaaccccg tgaactggta tcagcagctg      120

cccggcaccg cccccaagct gctgatctac cggaacaacc agcggcctag cggcgtgccc      180

gacagattca gcggcagcaa gagcggcacc agcgccagcc tggccatcag cggcctgaga      240

agcgaggacg aggccgacta ctactgcgcc gcctgggacg acagactgaa cggctggggc      300

ttcggcggag gcaccaagct gaccgtgctg ggacag                                336


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  105

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  106
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  106

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  107

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  108

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  109

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  110

Cys Ala Ala Trp Asp Asp Arg Leu Ser Gly Trp Ala 
1               5                   10          


<210>  111
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  112
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  112

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  113
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  113
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc gactaccaga tgacctggat cagacagacc      120

cccggcaagg gcctggaatg ggtgtccggc atctcctgga acggcggctc cacccactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagggcgac      300

tacctggtgt actcctccta ctacttcaag tcctggggcc agggcaccct ggtcaccgtc      360

agctca                                                                 366


<210>  114
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  114
cagtccgtgc tgacccagcc tccttccgcc tctggcaccc ctggccagag agtgaccatc       60

tcctgctccg gctcctcctc caacatcggc tccaaccccg tgaactggta tcagcagctg      120

cccggcaccg cccccaagct gctgatctac cggaacaacc agcggccctc cggcgtgccc      180

gacagattct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgaga      240

tctgaggacg aggccgacta ctactgcgcc gcctgggacg accggctgtc tggctgggct      300

tttggcggcg gaacaaagtt aaccgtgctg ggccag                                336


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  115

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  116

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  117

Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  118
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  118

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  119

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  120
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  120

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Ala 
1               5                   10          


<210>  121
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  121

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  122
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  122

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  123
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  123
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc gactaccaga tgacctggat cagacagacc      120

cccggcaagg gcctggaatg ggtgtccggc atctcctgga acggcggctc cacccactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagggcgac      300

tacctggtgt acaagtccta ctacttcaag tcctggggcc agggcaccct ggtcaccgtc      360

agctca                                                                 366


<210>  124
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  124
cagtccgtgc tgacccagcc tccttccgcc tctggcaccc ctggccagag agtgaccatc       60

tcctgctccg gctcctcctc caacatcggc tccaaccccg tgaactggta tcagcagctg      120

cccggcaccg cccccaagct gctgatctac cggaacaacc agcggccctc cggcgtgccc      180

gacagattct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgaga      240

tctgaggacg aggccgacta ctactgcgcc gcctgggacg actccctgtc tggctgggct      300

tttggcggcg gaacaaagtt aaccgtgctg ggccag                                336


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  125

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  126

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  127

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  128

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  129

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  130
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  130

Cys Ala Ala Trp Asp Asp Arg Leu Ser Gly Trp Gly 
1               5                   10          


<210>  131
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  131

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  132
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  132

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  133
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  133
gaggtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc gactaccaga tgacctggat cagacagacc      120

cccggcaagg gcctggaatg ggtgtccggc atctcctgga acggcggctc cacccactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagggcgac      300

tacctggtgt actcctccta ctacttcaag tcctggggcc agggcaccct ggtcaccgtc      360

agctca                                                                 366


<210>  134
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  134
cagtccgtgc tgacccagcc tccttccgcc tctggcaccc ctggccagag agtgaccatc       60

tcctgctccg gctcctcctc caacatcggc tccaaccccg tgaactggta tcagcagctg      120

cccggcaccg cccccaagct gctgatctac cggaacaacc agcggccctc cggcgtgccc      180

gacagattct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgaga      240

tctgaggacg aggccgacta ctactgcgcc gcctgggacg accggctgtc tggctgggga      300

tttggcggcg gaacaaagtt aaccgtgctg ggccag                                336


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  135

Phe Ser Ser Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  136
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  136

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  137

Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  138
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  138

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  139

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  140

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Ala 
1               5                   10          


<210>  141
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  141

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  142
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  142

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  143
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  143
gaggtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctaccaga tgacctggat cagacaggcc      120

cctggcaagg gcctggaatg ggtgtccggc atcagctgga acggcggcag cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggcgac      300

tacctggtgt acaagagcta ctacttcaag agctggggcc agggcacact ggtcaccgtc      360

agctca                                                                 366


<210>  144
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  144
cagagcgtgc tgacccagcc tcctagcgcc tctggcaccc ctggccagag agtgaccatc       60

agctgcagcg gcagcagcag caacatcggc agcaaccccg tgaactggta tcagcagctg      120

cccggcaccg cccccaagct gctgatctac cggaacaacc agcggcccag cggcgtgccc      180

gacagatttt ccggcagcaa gagcggcacc agcgccagcc tggccatcag cggcctgaga      240

agcgaggacg aggccgacta ctactgcgcc gcctgggacg atagcctgag cggctgggcc      300

tttggcggcg gaacaaagtt aaccgtgctg ggccag                                336


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  145

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  146
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  146

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  147

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  148
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  148

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  149

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  150
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  150

Cys Ala Ala Tyr Asp Asp Ser Leu Lys Gly Pro Val 
1               5                   10          


<210>  151
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  152
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  152

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Lys Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  153

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  154
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  154

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  155

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  156
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  156

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  157

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  158
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  158

Cys Ala Ala Phe Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  159
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  159

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  160
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  160

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  161

Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   


<210>  162
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  162

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  163

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  164
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  164

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  165

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  166

Cys Ala Ala Tyr Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10          


<210>  167
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  167

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  168
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  168

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  169

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  170
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  170

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  171

Ala Arg Glu Gly Leu Trp Ala Phe Asp Trp 
1               5                   10  


<210>  172
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  172

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  173

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  174
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  174

Cys Ala Ala Tyr Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10          


<210>  175
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  175

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Trp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  176
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  176

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  177

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  178
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  178

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  179

Ala Arg Glu Gly Leu Trp Ala Phe Asp Asn 
1               5                   10  


<210>  180
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  180

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  181

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  182
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  182

Cys Ala Ala Tyr Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  183
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  183

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  184
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  184

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  185

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  186
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  186

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  187

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  188
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  188

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  189

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  190
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  190

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Pro Val 
1               5                   10          


<210>  191
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  191

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  192
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  192

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  193
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  193

Phe Thr Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   10      


<210>  194
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  194

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  195

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  196
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  196

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  197

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  198
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  198

Cys Ala Ala Tyr Asp Asp Arg Leu Asn Gly Pro Val 
1               5                   10          


<210>  199
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  199

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  200
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  200

Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  201

Phe Thr Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   10      


<210>  202
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  202

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  203

Ala Arg Glu Gly Leu Trp Ala Phe Asp Gly 
1               5                   10  


<210>  204
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  204

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  205

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  206
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  206

Cys Ala Ala Tyr Asp Asp Ser Leu Asn Arg Pro Val 
1               5                   10          


<210>  207
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  208
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  208

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Asn Arg Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  209

Phe Thr Phe Ser Asn Ala Trp Met Ser Trp Val 
1               5                   10      


<210>  210
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  210

Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  211

Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr 
1               5                   10  


<210>  212
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  212

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  213

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  214
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  214

Cys Ala Ala Phe Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  215
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  216
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  216

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  217

Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   


<210>  218
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  218

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  219
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  219

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  220
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  220

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  221

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  222
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  222

Cys Ala Ala Phe Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  223
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  223

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  224
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  224

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  225
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  225

Phe Thr Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   10      


<210>  226
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  226

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  227

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  228
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  228

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  229

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  230
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  230

Cys Ala Ala Phe Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  231
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  231

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  232
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  232

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  233

Phe Thr Phe Ser Ser Ala Trp Met Ser Trp Val 
1               5                   10      


<210>  234
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  234

Val Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  235
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  235

Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys 
1               5                   10  


<210>  236
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  236

Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  237

Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210>  238
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  238

Cys Ala Ala Phe Asp Asp Arg Leu Ser Gly Pro Val 
1               5                   10          


<210>  239
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  239

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  240
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  240

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Arg 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  241

Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  242
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  242

Val Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  243
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  243

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  244
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  244

Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  245
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  245

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  246
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  246

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Trp Thr Gly 
1               5                   10              


<210>  247
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  247

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Thr Ser 
        115                 120         


<210>  248
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  248

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  249

Phe Thr Phe Ser Ser Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  250
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  250

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  251
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  251

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser 
1               5                   10                  15  


<210>  252
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  252

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  253

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  254
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  254

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Trp Gly 
1               5                   10          


<210>  255
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  255

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  256
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  256

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  257

Phe Thr Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  258
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  258

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  259

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Tyr 
1               5                   10                  15  


<210>  260
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  260

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  261

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  262
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  262

Cys Ala Ala Trp Asp Asp Arg Leu Asn Gly Trp Ala 
1               5                   10          


<210>  263
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  263

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  264
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  264

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  265
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  265

Phe Thr Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  266
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  266

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  267
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  267

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  268
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  268

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  269
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  269

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  270
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  270

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Gly 
1               5                   10          


<210>  271
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  271

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  272
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  272

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  273

Phe Thr Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  274
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  274

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  275
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  275

Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  276
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  276

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  277
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  277

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  278
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  278

Cys Ala Ala Trp Asp Asp Arg Leu Ser Gly Trp Gly 
1               5                   10          


<210>  279
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  279

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  280
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  280

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  281

Phe Thr Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  282
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  282

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  283
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  283

Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  284
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  284

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  285

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  286
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  286

Cys Ala Ala Trp Asp Asp Arg Leu Ser Gly Trp Gly 
1               5                   10          


<210>  287
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  287

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  288
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  288

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  289

Phe Thr Phe Ser Asp Tyr Gln Met Thr Trp Ile 
1               5                   10      


<210>  290
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  290

Val Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  291
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  291

Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser 
1               5                   10                  15  


<210>  292
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  292

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  293
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  293

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  294
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  294

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Gly 
1               5                   10          


<210>  295
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  295

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  296
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  296

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  297
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence for M20 D02 S-A derived CDR H1


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = D or S

<400>  297

Phe Ser Xaa Tyr Gln Met Thr Trp Ile 
1               5                   


<210>  298
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence for M20 D02 S-A derived CDRH2


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = V or I

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = A or G

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X = R or S

<400>  298

Val Ser Gly Xaa Ser Trp Asn Gly Xaa Xaa Thr His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  299
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus for M20 D02 S-A derived CDRH3


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = S, K, or R

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X =  A, S or R

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  X =  D, K, E or R

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  X =  S or Y

<400>  299

Ala Lys Gly Asp Tyr Leu Val Tyr Xaa Xaa Tyr Tyr Phe Xaa Xaa 
1               5                   10                  15  


<210>  300
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus seqeunce derived from M20 D02 S-A CDRL1


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X = V or I

<400>  300

Ser Gly Ser Ser Ser Asn Xaa Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  301
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M20 D02 S-A derived CDR L3


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = A, Q or R

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = D or G

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X = R or S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = N, W or S

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  X = V, A or G

<400>  301

Cys Ala Xaa Trp Xaa Asp Xaa Leu Xaa Gly Trp Xaa 
1               5                   10          


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR H1


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = N or S

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = A or Y

<400>  302

Phe Ser Xaa Xaa Trp Met Ser Trp Val 
1               5                   


<210>  303
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR H2


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X = T or S

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X = I or T

<400>  303

Val Ser Tyr Ile Ser Ser Ser Gly Ser Xaa Xaa Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  304
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR H3


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X = Y, K, G, W or N

<400>  304

Ala Arg Glu Gly Leu Trp Ala Phe Asp Xaa 
1               5                   10  


<210>  305
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR L1


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X = T or S

<400>  305

Xaa Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210>  306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR L2


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = K or Q

<400>  306

Asp Asn Asn Xaa Arg Pro Ser 
1               5           


<210>  307
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence derived from M31 B01 CDR L3


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = W, E, F or Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X = R, S or M

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = N, K or S

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X = G or R

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X = P or A

<400>  307

Cys Ala Ala Xaa Asp Asp Xaa Leu Xaa Xaa Xaa Val 
1               5                   10          


<210>  308
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  308
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgaccag c               351


<210>  309
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  309
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtatg atgatagcct gaaagggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  310
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  310
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgaccag c               351


<210>  311
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  311
cagagcgtgc tgacccagcc gccgagcgtg agcggggcgc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  312
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  312
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgaccag c               351


<210>  313
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  313
cagagcgtgc tgacccagcc gccgagcgtg agcggggcgc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  314
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  314
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgattggtg ggggcagggg accctggtga ccgtgaccag c               351


<210>  315
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  315
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtatg atgatagcct gagcgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  316
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  316
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgattattg ggggcagggg accctggtga ccgtgaccag c               351


<210>  317
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  317
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtatg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  318
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  318
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgattattg ggggcagggg accctggtga ccgtgagcag c               351


<210>  319
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  319
gagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtggg atgatcgcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  320
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  320
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgattattg ggggcagggg accctggtga ccgtgagcag c               351


<210>  321
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  321
gagagcgtgc tgacccagcc gccgagcgtg agcggggcgc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtatg atgatcgcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  322
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  322
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgatgggtg ggggcagggg accctggtga ccgtgagcag c               351


<210>  323
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  323
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtatg atgatagcct gaaccgcccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  324
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  324
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc aacgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcac catttattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgattattg ggggcagggg accctggtga ccgtgagcag c               351


<210>  325
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  325
cagagcgtgc tgacccagcc gccgagcgtg agcggggcgc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  326
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  326
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgaccag c               351


<210>  327
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  327
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcaccg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca acaaacgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  328
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  328
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgagcag c               351


<210>  329
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a

<400>  329
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatagcct gaacgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  330
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  330
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc agcgcgtgga tgagctgggt gcgccaggcg      120

ccggggaaag ggctggagtg ggtgagctat attagcagca gcgggagcag cacctattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gcgcgagggg      300

ctgtgggcgt ttgataaatg ggggcagggg accctggtga ccgtgagcag c               351


<210>  331
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  331
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg gcggggtatg tggtgcattg gtatcagcag      120

ctgccgggga ccgcgccgaa actgctgatt tatgataaca accagcgccc gagcggggtg      180

ccggatcgct ttagcgggag caaaagcggg accagcgcga gcctggcgat tagcgggctg      240

cgcagcgagg atgaggcgga ttattattgc gcggcgtttg atgatcgcct gagcgggccg      300

gtgtttgggg gggggaccaa actgaccgtg ctggggcag                             339


<210>  332
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  332
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg gtgagctgga acggggcgcg cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt atagcagcta ttattttaaa agctgggggc aggggaccct ggtgaccgtg      360

accagc                                                                 366


<210>  333
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  333
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacgtgggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atcgcctgaa cgggtggggg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  334
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  334
gagcagctgc tggagagcgg gggggggctg gtgcagccgg gggggagcct gcgcctgagc       60

tgcgcggcga gcgggtttac ctttagcagc tatcagatga cctggattcg ccagaccccg      120

gggaaagggc tggagtgggt gagcgggatt agctggaacg gggggagcac ccattatgcg      180

gatagcgtga aagggcgctt taccattagc cgcgataaca gcaaaaacac cctgtatctg      240

cagatgaaca gcctgcgcgc ggaggatacc gcggtgtatt attgcgcgaa aggggattat      300

ctggtgtata gcgcgtatta ttttgatagc tgggggcagg ggaccctggt gaccgtgagc      360

agc                                                                    363


<210>  335
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  335
caggtgctga cccagccgcc gagcgcgagc gggaccccgg ggcagcgcgt gaccattagc       60

tgcagcggga gcagcagcaa cattgggagc aacccggtga actggtatca gcagctgccg      120

gggaccgcgc cgaaactgct gatttatcgc aacaaccagc gcccgagcgg ggtgccggat      180

cgctttagcg ggagcaaaag cgggaccagc gcgagcctgg cgattagcgg gctgcgcagc      240

gaggatgagg cggattatta ttgcgcggcg tgggatgatc gcctgaacgg gtgggggttt      300

ggggggggga ccaaactgac cgtgctgggg cag                                   333


<210>  336
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  336
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg attagctgga acggggggag cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt atagcagcta ttattttaaa tattgggggc aggggaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  337
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  337
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atcgcctgaa cgggtgggcg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  338
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  338
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg attagctgga acggggggag cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt atagcagcta ttattttaaa agctgggggc aggggaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  339
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  339
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atagcctgaa cgggtggggg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  340
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  340
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg attagctgga acggggggag cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt ataaaagcta ttattttaaa agctgggggc aggggaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  341
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  341
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atcgcctgag cgggtggggg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  342
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  342
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg attagctgga acggggggag cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt atagcagcta ttattttaaa agctgggggc aggggaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  343
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  343
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atcgcctgag cgggtggggg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  344
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  344
gaggtgcagc tgctggagag cggggggggg ctggtgcagc cgggggggag cctgcgcctg       60

agctgcgcgg cgagcgggtt tacctttagc gattatcaga tgacctggat tcgccagacc      120

ccggggaaag ggctggagtg ggtgagcggg attagctgga acggggggag cacccattat      180

gcggatagcg tgaaagggcg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaggat accgcggtgt attattgcgc gaaaggggat      300

tatctggtgt ataaaagcta ttattttaaa agctgggggc aggggaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  345
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4.4a binder

<400>  345
cagagcgtgc tgacccagcc gccgagcgcg agcgggaccc cggggcagcg cgtgaccatt       60

agctgcagcg ggagcagcag caacattggg agcaacccgg tgaactggta tcagcagctg      120

ccggggaccg cgccgaaact gctgatttat cgcaacaacc agcgcccgag cggggtgccg      180

gatcgcttta gcgggagcaa aagcgggacc agcgcgagcc tggcgattag cgggctgcgc      240

agcgaggatg aggcggatta ttattgcgcg gcgtgggatg atagcctgaa cgggtggggg      300

tttggggggg ggaccaaact gaccgtgctg gggcag                                336


<210>  346
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  346

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  347
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  347

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  348
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  348

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  349
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  349

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  350
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  350

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  351
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  351

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  352
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  352

Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  353
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  353

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  354
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  354

Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  355
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  355

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  356
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  356

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  357
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  357

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  358
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  358

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Asn Arg Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  359
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  359

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  360
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  360

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Arg 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  361
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  361

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  362
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  362

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  363
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  363

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  364
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  364

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Tyr Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  365
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  365

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  366
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  366

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  367
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  367

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  368
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  368

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Phe Asp Asp Arg 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  369
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  369

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Trp Ala Phe Asp Lys Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  370
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  370

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  371
<211>  452
<212>  PRT
<213>  Homo Sapiens

<400>  371

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  372
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  372

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  373
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  373

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ala Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  374
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  374

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  375
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  375

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  376
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  376

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  377
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  377

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  378
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  378

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  379
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  379

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  380
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  380

Glu Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  381
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  381

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ala Tyr Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  382
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  382

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  383
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  383

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  384
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  384

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  385
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  385

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  386
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  386

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  387
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  387

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  388
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  388

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  389
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  389

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  390
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  390

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  391
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  391

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  392
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  392

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  393
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  393

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Ser Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  394
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  394

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  395
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  395

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  396
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  396

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  397
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  397

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Tyr Leu Val Tyr Lys Ser Tyr Tyr Phe Lys Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  398
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  398

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  399
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  399

Trp Met Gly Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro 
1               5                   10                  15      


Ser Phe Gln Gly 
            20  


<210>  400
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  400

Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly 
1               5                   10      


<210>  401
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  401

Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asn Ser Val Ser 
1               5                   10                  


<210>  402
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  402

Leu Met Ile Tyr Gly Val Asn Asn Arg Pro Ser 
1               5                   10      


<210>  403
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  403

Ser Ser Tyr Asp Ile Glu Ser Ala Thr Pro 
1               5                   10  


<210>  404
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  404

Gln Val Glu Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  405
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  405

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 
                85                  90                  95      


Ser Ala Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  406
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  406
caggtggaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gttccggata ttcctttact tcttattgga ttggttgggt gcgccaggcc      120

cctgggaagg gtctcgagtg gatgggcatt atcgatccgg gtgatagccg tacccgttat      180

tctccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc gcgtggtcag      300

ctttatggtg gtacttatat ggatggttgg ggccaaggca ccctggtgac ggttagctca      360


<210>  407
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  407
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatattggt ggttataatt ctgtgtcttg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgtta ataatcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc tcttcttatg atattgagtc tgctactcct      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcag                             339


<210>  408
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  408

Gln Val Glu Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  409
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  409

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 
                85                  90                  95      


Ser Ala Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  410
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  410
caggtggaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt       60

agctgcaaag gttccggata ttcctttact tcttattgga ttggttgggt gcgccaggcc      120

cctgggaagg gtctcgagtg gatgggcatt atcgatccgg gtgatagccg tacccgttat      180

tctccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat      240

cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc gcgtggtcag      300

ctttatggtg gtacttatat ggatggttgg ggccaaggca ccctggtgac ggttagctca      360

gcctccacca agggtccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa tga                                  1353


<210>  411
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  411
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatattggt ggttataatt ctgtgtcttg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgtta ataatcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc tcttcttatg atattgagtc tgctactcct      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga agggagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


